SI3061760T1 - Devterirani derivati benzokinolizina kot inhibitorji vezikularnega monoaminskega transporterja 2 - Google Patents
Devterirani derivati benzokinolizina kot inhibitorji vezikularnega monoaminskega transporterja 2 Download PDFInfo
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- SI3061760T1 SI3061760T1 SI200931797T SI200931797T SI3061760T1 SI 3061760 T1 SI3061760 T1 SI 3061760T1 SI 200931797 T SI200931797 T SI 200931797T SI 200931797 T SI200931797 T SI 200931797T SI 3061760 T1 SI3061760 T1 SI 3061760T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Claims (13)
- Devterirani derivati benzokinolizina kot inhibitorji vezikulamega monoaminskega transporterja 2 Patentni zahtevki1. Spojina,ali njena sol za uporabo v zdravljenju kronične hiperkinetične motnje gibanja.
- 2. Spojina za uporabo po zahtevku 1, kjer je omenjena kronična hiperkinetična motnja gibanja Tourettov sindrom.
- 3. Spoj ina za uporabo po zahtevku 1, kjer je omenjena kronična hiperkinetična motnja gibanja tardivna diskinezija.
- 4. Spojina za uporabo po zahtevku 1, kjer je omenjena kronična hiperkinetična motnja gibanja tik.
- 5. Spojina za uporabo po zahtevku 1 v kombinaciji z dodatnim terapevtskim sredstvom.
- 6. Spojina za uporabo po zahtevku 5, kjer je omenjeno dodatno terapevtsko sredstvo izbrano iz skupine, ki vsebuje olanzapin in pimozid.
- 7. Spojina za uporabo po zahtevku 6, kjer je omenjeno dodatno terapevtsko sredstvo izbrano iz skupine, ki vsebuje benzodiazepine in antipsihotike.
- 8. Spojina za uporabo po zahtevku 7, kjer je omenjeni benzodiazepin izbran iz skupine, ki vsebuje alprazolam, adinazolam, bromazepam, kamazepam, klobazam, klonazepam, clotiazepam, kloksazolam, diazepam, etil loflazepat, estizolam, fludiazepam, flunitrazepam, halazepam, ketazolam, lorazepam, medazepam, dazolam, nitrazepam, nordazepam, oksazepam, kalijev klorazepat, pinazepam, prazepam, tofisopam, triazolam, temazepam in klordiazepoksid.
- 9. Spojina za uporabo po zahtevku 7, kjer je omenjeni antipsihotik izbran iz skupin, ki vsebuje klorpromazin, levomepromazin, promazi, acepromazin, triflupromazin, ciamemazin, klorproetazin, diksirazin, flufenazin, perfenazin, proklorperazin, tiopropazat, trifluoperazin, acetofenazin, tioproperazin, butaperazin, perazin, periciazin, tioridazin, mesoridazin, pipotiazin, haloperidol, trifluperidol, melperon, moperon, pipamperon, bromperidol, benperidol, droperidol, fluanison, oksipertin, molindon, sertindol, ziprazidon, flupentiksol, clopentiksol, klorprotiksen, tiotiksen, zuklopentiksol, fluspirilen, pimozid, penfluridol, loksapin, klozapin, olanzapin, kvetiapin, tetrabenazin, sulpirid, sultoprid, tiaprid, remoksiprid, amisulprid, veraliprid, levosulpirid, litij, protipendil, risperidon, klotiapin, mozapramin, zotepin, pripiprazol in paliperidon.
- 10. Spojina za uporabo po zahtevku 1, kjer ima vsak položaj, kije predstavljen kot D obogatitev z devterijem ne manj kot približno 10%.
- 11. Spojina za uporabo po zahtevku 1, kjer ima vsak položaj, kije predstavljen kot D obogatitev z devterijem ne manj kot približno 50%.
- 12. Spojina za uporabo po zahtevku 1, kjer ima vsak položaj, kije predstavljen kot D obogatitev z devterijem ne manj kot približno 90%.
- 13. Spojina za uporabo po zahtevku 1, kjer ima vsak položaj, kije predstavljen kot D obogatitev z devterijem ne manj kot približno 98%.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9789608P | 2008-09-18 | 2008-09-18 | |
| EP15185548.3A EP3061760B1 (en) | 2008-09-18 | 2009-09-18 | Deuterated benzoquinolizine derivatives as inhibitors of vesicular monoamine transporter 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3061760T1 true SI3061760T1 (sl) | 2018-04-30 |
Family
ID=42107127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200931797T SI3061760T1 (sl) | 2008-09-18 | 2009-09-18 | Devterirani derivati benzokinolizina kot inhibitorji vezikularnega monoaminskega transporterja 2 |
Country Status (20)
| Country | Link |
|---|---|
| US (15) | US8524733B2 (sl) |
| EP (4) | EP2326643B1 (sl) |
| JP (3) | JP5616345B2 (sl) |
| CN (2) | CN104311552A (sl) |
| AU (1) | AU2009303758B8 (sl) |
| BR (1) | BRPI0913457B8 (sl) |
| CA (2) | CA2736409C (sl) |
| CY (1) | CY1120060T1 (sl) |
| DK (2) | DK3061760T3 (sl) |
| ES (4) | ES2896678T3 (sl) |
| HK (3) | HK1186728A1 (sl) |
| HR (1) | HRP20180239T1 (sl) |
| HU (1) | HUE038158T2 (sl) |
| LT (1) | LT3061760T (sl) |
| NO (1) | NO3061760T3 (sl) |
| NZ (1) | NZ591615A (sl) |
| PL (1) | PL3061760T3 (sl) |
| PT (1) | PT3061760T (sl) |
| SI (1) | SI3061760T1 (sl) |
| WO (1) | WO2010044981A2 (sl) |
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