SI2852384T1 - Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano (3,4,b)indol)-4-amine and an anticonvulsant - Google Patents

Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano (3,4,b)indol)-4-amine and an anticonvulsant

Info

Publication number
SI2852384T1
SI2852384T1 SI201330569A SI201330569A SI2852384T1 SI 2852384 T1 SI2852384 T1 SI 2852384T1 SI 201330569 A SI201330569 A SI 201330569A SI 201330569 A SI201330569 A SI 201330569A SI 2852384 T1 SI2852384 T1 SI 2852384T1
Authority
SI
Slovenia
Prior art keywords
pyrano
anticonvulsant
indol
4r
spiro
Prior art date
Application number
SI201330569A
Other languages
Slovenian (sl)
Inventor
Stefanie Frosch
Klaus Linz
Thomas Christoph
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP12003898 priority Critical
Priority to EP13159330 priority
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Priority to EP13723004.1A priority patent/EP2852384B1/en
Priority to PCT/EP2013/001471 priority patent/WO2013170972A1/en
Publication of SI2852384T1 publication Critical patent/SI2852384T1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
SI201330569A 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano (3,4,b)indol)-4-amine and an anticonvulsant SI2852384T1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP12003898 2012-05-18
EP13159330 2013-03-15
EP13723004.1A EP2852384B1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an anticonvulsant
PCT/EP2013/001471 WO2013170972A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an anticonvulsant

Publications (1)

Publication Number Publication Date
SI2852384T1 true SI2852384T1 (en) 2017-04-26

Family

ID=48446244

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201330569A SI2852384T1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano (3,4,b)indol)-4-amine and an anticonvulsant

Country Status (21)

Country Link
US (1) US9345689B2 (en)
EP (1) EP2852384B1 (en)
JP (1) JP6116679B2 (en)
CN (1) CN104284656A (en)
AU (1) AU2013262078B2 (en)
CA (1) CA2873871A1 (en)
CY (1) CY1118634T1 (en)
DK (1) DK2852384T3 (en)
EA (1) EA029767B1 (en)
ES (1) ES2624220T3 (en)
HK (1) HK1204937A1 (en)
HR (1) HRP20170517T1 (en)
HU (1) HUE031984T2 (en)
IL (1) IL235654A (en)
LT (1) LT2852384T (en)
MX (1) MX353177B (en)
PL (1) PL2852384T3 (en)
PT (1) PT2852384T (en)
RS (1) RS55905B1 (en)
SI (1) SI2852384T1 (en)
WO (1) WO2013170972A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2974578A1 (en) 2015-01-23 2016-07-28 Grunenthal Gmbh Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function

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AU2011287955B2 (en) * 2010-08-04 2015-07-09 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(N-methyl- or N,N-dimethyl-)-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of neuropathic pain
CA2804077C (en) * 2010-08-04 2018-09-11 Gruenenthal Gmbh Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
RS55905B1 (en) 2017-09-29
CN104284656A (en) 2015-01-14
HK1204937A1 (en) 2015-12-11
IL235654D0 (en) 2015-01-29
ES2624220T3 (en) 2017-07-13
HRP20170517T1 (en) 2017-06-02
WO2013170972A1 (en) 2013-11-21
IL235654A (en) 2017-07-31
MX2014013179A (en) 2015-01-19
EA201401271A1 (en) 2015-05-29
US20130317009A1 (en) 2013-11-28
AU2013262078B2 (en) 2017-10-26
US9345689B2 (en) 2016-05-24
EA029767B1 (en) 2018-05-31
MX353177B (en) 2018-01-05
PT2852384T (en) 2017-05-10
DK2852384T3 (en) 2017-05-08
CY1118634T1 (en) 2017-07-12
JP2015516452A (en) 2015-06-11
AU2013262078A1 (en) 2015-01-22
EP2852384A1 (en) 2015-04-01
JP6116679B2 (en) 2017-04-19
HUE031984T2 (en) 2017-08-28
CA2873871A1 (en) 2013-11-21
EP2852384B1 (en) 2017-02-01
LT2852384T (en) 2017-04-25
PL2852384T3 (en) 2017-09-29

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