SI1908760T1 - Kroman in tiokroman-3il-1,3-dihidroimidazoli kot inhibitorji dopamin-betahidroksilaze in postopek priprave - Google Patents
Kroman in tiokroman-3il-1,3-dihidroimidazoli kot inhibitorji dopamin-betahidroksilaze in postopek pripraveInfo
- Publication number
- SI1908760T1 SI1908760T1 SI200331986T SI200331986T SI1908760T1 SI 1908760 T1 SI1908760 T1 SI 1908760T1 SI 200331986 T SI200331986 T SI 200331986T SI 200331986 T SI200331986 T SI 200331986T SI 1908760 T1 SI1908760 T1 SI 1908760T1
- Authority
- SI
- Slovenia
- Prior art keywords
- dihydroimidazoles
- thiochromane
- chromane
- hydroxylase
- dopamine
- Prior art date
Links
- FVVJXNLMRXNHCY-UHFFFAOYSA-N 3-(3,4-dihydro-2h-thiochromen-3-yl)-1,2-dihydroimidazole Chemical class C1NC=CN1C1CC2=CC=CC=C2SC1 FVVJXNLMRXNHCY-UHFFFAOYSA-N 0.000 title 1
- 108010015720 Dopamine beta-Hydroxylase Proteins 0.000 title 1
- 102100033156 Dopamine beta-hydroxylase Human genes 0.000 title 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223719A GB2393958A (en) | 2002-10-11 | 2002-10-11 | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
| GB0224306A GB2394223B (en) | 2002-10-11 | 2002-10-18 | Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation |
| EP07076125A EP1908760B1 (en) | 2002-10-11 | 2003-10-10 | Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1908760T1 true SI1908760T1 (sl) | 2011-05-31 |
Family
ID=9945777
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331309T SI1408038T1 (sl) | 2002-10-11 | 2003-10-10 | Derivati imidazola in njihova uporaba kot periferno selektivni inhibitor dopamin-beta-hidroksilaze |
| SI200331986T SI1908760T1 (sl) | 2002-10-11 | 2003-10-10 | Kroman in tiokroman-3il-1,3-dihidroimidazoli kot inhibitorji dopamin-betahidroksilaze in postopek priprave |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331309T SI1408038T1 (sl) | 2002-10-11 | 2003-10-10 | Derivati imidazola in njihova uporaba kot periferno selektivni inhibitor dopamin-beta-hidroksilaze |
Country Status (11)
| Country | Link |
|---|---|
| KR (1) | KR101350741B1 (el) |
| CN (1) | CN100393715C (el) |
| AR (2) | AR041589A1 (el) |
| AT (5) | ATE500248T1 (el) |
| CY (2) | CY1108452T1 (el) |
| DE (4) | DE60336772D1 (el) |
| DK (2) | DK1908760T3 (el) |
| ES (5) | ES2361939T3 (el) |
| GB (2) | GB2393958A (el) |
| HK (1) | HK1116188A1 (el) |
| SI (2) | SI1408038T1 (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0708818D0 (en) * | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
| JP6161538B2 (ja) * | 2010-12-22 | 2017-07-12 | バイアル−ポルテラ アンド シーエー，エス．エー． | 結晶形及びその製造方法 |
| GB201316410D0 (en) * | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL82401A0 (en) * | 1986-05-06 | 1987-11-30 | Merrell Dow Pharma | Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them |
| US4868210A (en) | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| ATE243199T1 (de) * | 1994-04-26 | 2003-07-15 | Syntex Llc | Benzocyclohexylimidazolthion-derivate |
-
2002
- 2002-10-11 GB GB0223719A patent/GB2393958A/en not_active Withdrawn
- 2002-10-18 GB GB0224306A patent/GB2394223B/en not_active Expired - Lifetime
-
2003
- 2003-10-10 DE DE60336772T patent/DE60336772D1/de not_active Expired - Lifetime
- 2003-10-10 CN CNB2003801059426A patent/CN100393715C/zh not_active Expired - Fee Related
- 2003-10-10 SI SI200331309T patent/SI1408038T1/sl unknown
- 2003-10-10 AR ARP030103711A patent/AR041589A1/es active IP Right Grant
- 2003-10-10 ES ES07076124T patent/ES2361939T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076122T patent/ATE500248T1/de not_active IP Right Cessation
- 2003-10-10 DK DK07076125.9T patent/DK1908760T3/da active
- 2003-10-10 AT AT03256420T patent/ATE403652T1/de active
- 2003-10-10 AT AT07076125T patent/ATE505465T1/de active
- 2003-10-10 DK DK03256420T patent/DK1408038T3/da active
- 2003-10-10 ES ES07076122T patent/ES2361938T3/es not_active Expired - Lifetime
- 2003-10-10 ES ES07076123T patent/ES2384118T3/es not_active Expired - Lifetime
- 2003-10-10 SI SI200331986T patent/SI1908760T1/sl unknown
- 2003-10-10 AT AT07076123T patent/ATE550335T1/de active
- 2003-10-10 KR KR1020127005102A patent/KR101350741B1/ko active IP Right Grant
- 2003-10-10 DE DE60322642T patent/DE60322642D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60336276T patent/DE60336276D1/de not_active Expired - Lifetime
- 2003-10-10 DE DE60336275T patent/DE60336275D1/de not_active Expired - Lifetime
- 2003-10-10 ES ES03256420T patent/ES2309279T3/es not_active Expired - Lifetime
- 2003-10-10 ES ES07076125T patent/ES2364919T3/es not_active Expired - Lifetime
- 2003-10-10 AT AT07076124T patent/ATE500247T1/de not_active IP Right Cessation
-
2008
- 2008-10-09 HK HK08111214.9A patent/HK1116188A1/xx not_active IP Right Cessation
- 2008-10-24 CY CY20081101204T patent/CY1108452T1/el unknown
-
2011
- 2011-07-01 CY CY20111100639T patent/CY1112457T1/el unknown
-
2014
- 2014-03-18 AR ARP140101283A patent/AR095674A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120038014A (ko) | 2012-04-20 |
| ES2361938T3 (es) | 2011-06-24 |
| DE60322642D1 (de) | 2008-09-18 |
| DE60336772D1 (de) | 2011-05-26 |
| ATE550335T1 (de) | 2012-04-15 |
| KR101350741B1 (ko) | 2014-01-10 |
| ATE500247T1 (de) | 2011-03-15 |
| HK1116188A1 (en) | 2008-12-19 |
| GB2394223A (en) | 2004-04-21 |
| DK1908760T3 (da) | 2011-07-25 |
| GB0224306D0 (en) | 2002-11-27 |
| CN1726211A (zh) | 2006-01-25 |
| ATE403652T1 (de) | 2008-08-15 |
| GB0223719D0 (en) | 2002-11-20 |
| ES2361939T3 (es) | 2011-06-24 |
| GB2394223B (en) | 2007-05-16 |
| ES2309279T3 (es) | 2008-12-16 |
| DE60336275D1 (de) | 2011-04-14 |
| DK1408038T3 (da) | 2008-11-24 |
| DE60336276D1 (de) | 2011-04-14 |
| ATE500248T1 (de) | 2011-03-15 |
| ES2384118T3 (es) | 2012-06-29 |
| CY1108452T1 (el) | 2014-04-09 |
| ES2364919T3 (es) | 2011-09-16 |
| AR095674A2 (es) | 2015-11-04 |
| ATE505465T1 (de) | 2011-04-15 |
| CY1112457T1 (el) | 2015-12-09 |
| CN100393715C (zh) | 2008-06-11 |
| SI1408038T1 (sl) | 2008-10-31 |
| GB2393958A (en) | 2004-04-14 |
| AR041589A1 (es) | 2005-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL176478A0 (en) | Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the faah enzyme | |
| EP1911757B8 (en) | Method of preparation of 3-(1,3-Dihydroimidazole-2-thione-1-yl)-chromanes and thiochromanes as dopamine-beta-hydroxylase inhibitors | |
| IL164703A0 (en) | ImidazoÄ1,2-AÜpyrazin-8-ylamines method of making and method of use thereof | |
| EP1578719A4 (en) | P-HYDROXY-MILNACIPRAN STEREOISOMERS AND METHODS OF USING THE SAME | |
| AU2003220586A1 (en) | Game piece and system and method of use | |
| AU2003248721A1 (en) | Adsorbents, methods of preparation, and methods of use thereof | |
| IL177422A0 (en) | Derivatives of alkylpiperazine-and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as faah enzyme inhibitors | |
| HK1081957A1 (en) | Benzopyranone compounds, compositions thereof, and methods of treatment therewith | |
| ZA200606964B (en) | Derivatives of piperidinylalkylcarbamates, preparation method thereof and use of same as faah enzyme inhibitors | |
| AU2003271944A1 (en) | Methods for making water treatment compositions and compositions thereof | |
| AU2002228317A1 (en) | Benz-1,3-azole derivatives and their uses as heparanase inhibitors | |
| AU2003288221A1 (en) | Skin lightening derivatives of di-thiane resorcinol, compositions and methods | |
| EP1668125A4 (en) | MODIFIED ENZYMES, PROCESSES FOR PRODUCING MODIFIED ENZYMES AND USES THEREOF | |
| EP1667999A4 (en) | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND TREATMENT METHOD USING THE SAME | |
| EP1624880A4 (en) | ANNATTO EXTRACT COMPOSITIONS WITH GERANYL GERANIOLS AND METHOD OF USE | |
| AU2003275056A1 (en) | Novel lapacho compounds and methods of use thereof | |
| HK1101759A1 (en) | Derivatives of heteroaryl-alkylcarbamates, preparation method thereof and use of same as faah enzyme inhibitors | |
| PL377999A1 (pl) | Pochodne acyloaminotiazolu, sposób ich wytwarzania i ich zastosowanie jako inhibitorów syntezy peptydu ß-amyloidu | |
| SI1908760T1 (sl) | Kroman in tiokroman-3il-1,3-dihidroimidazoli kot inhibitorji dopamin-betahidroksilaze in postopek priprave | |
| HU0200306D0 (en) | Method for preparation of absorbent article, the absorbent article and application of it | |
| AU2002357561A8 (en) | Oxazolidine derivative, methods of preparation and uses | |
| AU2003303815A1 (en) | Alanines compounds, method of preparing them and their use | |
| AU2003282980A1 (en) | 4-alkenylthiazoles comprising epoxide functionality, and methods of use thereof | |
| AU2003300607A1 (en) | Mannuronan c5-epimerases of brown algae, methods of obtaining same and use thereof | |
| AU2003289640A1 (en) | Tricyclacetalactonin, Preparation and Use there of |