SI1853631T1 - Fuzijski konstrukti, ki zajemajo regijo FC in se vežejo na fosfatidilserine, ter njihova terapevtska uporaba - Google Patents

Fuzijski konstrukti, ki zajemajo regijo FC in se vežejo na fosfatidilserine, ter njihova terapevtska uporaba

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Publication number
SI1853631T1
SI1853631T1 SI200632035T SI200632035T SI1853631T1 SI 1853631 T1 SI1853631 T1 SI 1853631T1 SI 200632035 T SI200632035 T SI 200632035T SI 200632035 T SI200632035 T SI 200632035T SI 1853631 T1 SI1853631 T1 SI 1853631T1
Authority
SI
Slovenia
Prior art keywords
phosphatidylserine
therapeutic use
fusion constructs
constructs binding
binding
Prior art date
Application number
SI200632035T
Other languages
English (en)
Inventor
Philip E Thorpe
Troy A Luster
Steven W. King
Original Assignee
Board Of Regents, The University Of Texas System
Peregrine Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Regents, The University Of Texas System, Peregrine Pharmaceuticals, Inc. filed Critical Board Of Regents, The University Of Texas System
Publication of SI1853631T1 publication Critical patent/SI1853631T1/sl

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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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SI200632035T 2005-01-24 2006-01-24 Fuzijski konstrukti, ki zajemajo regijo FC in se vežejo na fosfatidilserine, ter njihova terapevtska uporaba SI1853631T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64633305P 2005-01-24 2005-01-24
EP06719706.1A EP1853631B1 (en) 2005-01-24 2006-01-24 Fc FUSION CONSTRUCTS BINDING TO PHOSPHATIDYLSERINE AND THEIR THERAPEUTIC USE
PCT/US2006/002964 WO2006079120A2 (en) 2005-01-24 2006-01-24 Fc-fusion constructs binding to phosphatidylserine and their therapeutic use

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SI1853631T1 true SI1853631T1 (sl) 2016-04-29

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SI200632035T SI1853631T1 (sl) 2005-01-24 2006-01-24 Fuzijski konstrukti, ki zajemajo regijo FC in se vežejo na fosfatidilserine, ter njihova terapevtska uporaba

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US (3) US8956616B2 (sl)
EP (1) EP1853631B1 (sl)
JP (2) JP5127043B2 (sl)
CN (3) CN101146826A (sl)
AU (1) AU2006206187B2 (sl)
CA (1) CA2591914C (sl)
DK (1) DK1853631T3 (sl)
ES (1) ES2565543T3 (sl)
HK (2) HK1198255A1 (sl)
IL (1) IL184406A (sl)
NZ (1) NZ556065A (sl)
SG (1) SG158919A1 (sl)
SI (1) SI1853631T1 (sl)
WO (1) WO2006079120A2 (sl)

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Publication number Priority date Publication date Assignee Title
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
GB0707034D0 (en) * 2007-04-12 2007-05-23 St Andrews The Compounds
US20110064744A1 (en) * 2007-05-30 2011-03-17 Sabbadini Roger A Prevention and treatment of pain using antibodies to lysophosphatidic acid
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
US8158124B2 (en) * 2007-05-30 2012-04-17 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
EP2209420A4 (en) 2007-10-09 2014-01-22 Univ St Louis IMAGING PARTICLES
US9468607B2 (en) 2007-10-09 2016-10-18 Washington University Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
WO2009065065A1 (en) * 2007-11-15 2009-05-22 Ceramoptec Industries, Inc. Pegylated liposomal formulations for photodynamic treatment of inflammatory diseases
GB0723797D0 (en) 2007-12-05 2008-01-16 Immunosolv Ltd Method
WO2009089098A1 (en) * 2008-01-03 2009-07-16 Musc Foundation For Research Development Methods for the treatment of cancers
CN102046151A (zh) * 2008-03-26 2011-05-04 牛津大学 靶向内质网的脂质体
GB0819287D0 (en) 2008-10-22 2008-11-26 Univ Bradford Compounds
NZ593281A (en) 2008-12-05 2012-12-21 Abraxis Bioscience Llc Sparc binding peptides and uses thereof
WO2011036467A1 (en) * 2009-09-24 2011-03-31 Russell David Keenan Products useful in the treatment of haemophilia
WO2011069090A1 (en) * 2009-12-04 2011-06-09 Alavita Pharmaceuticals, Inc. Inhibition of the activation of coagulation factor xii by ligands of phosphatidylserine
EP2512452B1 (en) 2009-12-17 2018-09-19 The Washington University Antithrombotic nanoparticle
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
EP2369551B1 (en) * 2010-03-25 2019-10-30 Emory University Imaging system and method
CA2796435C (en) * 2010-04-15 2019-05-07 The Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
CN105524176B (zh) * 2010-05-21 2021-03-19 银溪制药股份有限公司 双特异性融合蛋白
EP2571992B1 (en) 2010-05-21 2018-04-25 Merrimack Pharmaceuticals, Inc. Bi-specific fusion proteins
WO2012030949A2 (en) * 2010-09-01 2012-03-08 Kansas State University Research Foundation B2-glycoprotein i peptide inhibitors
US9901616B2 (en) 2011-08-31 2018-02-27 University Of Georgia Research Foundation, Inc. Apoptosis-targeting nanoparticles
US9463217B1 (en) * 2012-02-10 2016-10-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and pharmaceutical compositions for treatment of retinal occlusion
WO2013123298A1 (en) 2012-02-17 2013-08-22 University Of Georgia Research Foundation, Inc. Nanoparticles for mitochondrial trafficking of agents
CA2879542A1 (en) * 2012-07-25 2014-01-30 Salk Institute For Biological Studies Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine
US20140287024A1 (en) * 2013-03-08 2014-09-25 Shu Wang Nanoparticle-based delivery system with oxidized phospholipids as targeting ligands for the prevention, diagnosis and treatment of atherosclerosis
EP3524617B1 (en) * 2013-03-15 2023-04-12 GLAdiator Biosciences, Inc. Gla domains as therapeutic agents
GB2516882A (en) 2013-08-02 2015-02-11 Univ Bradford Tumour-targeted theranostic
AU2014365838B2 (en) 2013-12-16 2021-01-14 The University Of North Carolina At Chapel Hill Depletion of plasmacytoid dendritic cells
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
CN106536056B (zh) 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
ES2912989T3 (es) * 2015-05-05 2022-05-30 Rubicon Biotechnology Llc Inmunoterapia para cáncer
AU2016276750A1 (en) 2015-06-09 2018-01-18 The Board Of Regents Of The University Of Texas System Diagnostic test for early stage cancer
US10040840B2 (en) * 2015-10-02 2018-08-07 Silver Creek Pharmaceuticals, Inc. Bi-specific annexin A5/IGF-1 proteins and methods of use thereof to promote regeneration and survival of tissue
CN108430499B (zh) 2015-12-15 2022-07-19 肿瘤免疫股份有限公司 嵌合和人源化抗人类ctla4单克隆抗体和其用途
EP3735976A3 (en) * 2016-01-15 2021-01-27 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
WO2017133018A1 (zh) * 2016-02-06 2017-08-10 法玛科技顾问股份有限公司 重组β2-糖蛋白胜肽及其于抗肿瘤的应用
CN109195992A (zh) * 2016-04-29 2019-01-11 本康生物制药(深圳)有限公司 多特异性结合偶联物、相关的药物组合物及应用
WO2017219974A1 (zh) 2016-06-22 2017-12-28 本康生物制药(深圳)有限公司 用于肿瘤治疗的双特异性抗体和抗体偶联物及其应用
EA038617B1 (ru) * 2016-07-06 2021-09-23 Онкоиммьюн, Инк. Химерные и гуманизированные античеловеческие ctla-4 моноклональные антитела и их использование
ES2912269T3 (es) 2016-09-27 2022-05-25 Cero Therapeutics Inc Moléculas de receptor de engullimiento quimérico
MX2019003569A (es) 2016-09-27 2020-07-22 Oncologie Inc Metodos para tratar el cancer con bavituximab en funcion de niveles de b2 glucoproteina 1 y ensayos de estos.
KR20200020662A (ko) 2017-04-03 2020-02-26 온콜로지, 인크. 면역-종양학 제제와 함께 ps-표적화 항체를 사용하여 암을 치료하는 방법
CN108727489B (zh) * 2017-04-19 2021-02-09 广州市第八人民医院 一种单克隆抗体zk2c2及应用
WO2019023156A1 (en) * 2017-07-24 2019-01-31 Rutgers, The State University Of New Jersey PHOSPHATIDYLSERIN-TARGETING FUSION MOLECULES AND METHODS OF USE
US11661447B2 (en) 2017-08-03 2023-05-30 The Cleveland Clinic Foundation Human β2-glycoprotein I expression
JP7365704B2 (ja) * 2017-09-05 2023-10-20 グラディエーター バイオサイエンシーズ インコーポレイテッド 幹細胞へのペイロードの送達
US11708423B2 (en) 2017-09-26 2023-07-25 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules and methods of use
CN108021784B (zh) * 2017-12-01 2021-05-11 大连理工大学 纳米金属氧化物光致产生活性氧物种的预测方法
ES2727261B2 (es) * 2018-04-12 2020-05-06 Fundacion Para La Investig Biomedica Del Hospital 12 De Octubre INMUNOCOMPLEJOS ARTIFICIALES Y SU USO COMO CALIBRES EN SISTEMAS DE DETECCION DE INMUNOCOMPLEJOS CIRCULANTES B2GP1-aB2GP1
WO2020097165A1 (en) * 2018-11-08 2020-05-14 Nasr Mahmoud Nanodiscs for preventing and treating pathogen infections and methods of use thereof
TW202039583A (zh) 2018-12-07 2020-11-01 瑞士商巴克斯歐塔有限公司 結合因子IXa及因子X的蛋白分子
WO2020114614A1 (en) 2018-12-07 2020-06-11 Baxalta GmbH Proteinaceous molecules binding factor ixa and factor x
EP3711772A1 (en) * 2019-03-20 2020-09-23 Oslo Universitetssykehus HF Recombinant proteins and fusion proteins
WO2020264181A1 (en) * 2019-06-28 2020-12-30 The Board Of Regents Of The University Of Oklahoma Therapeutic annexin-drug conjugates and methods of use
US20220033426A1 (en) * 2020-07-28 2022-02-03 Yale University Transition Metal Macrocyclics as MRI Contrast Agents for Molecular Imaging
EP4188361A1 (en) * 2020-08-21 2023-06-07 The University of Chicago Nanoparticles containing multiple cleavable produgs for cancer therapy
JP2024512207A (ja) * 2021-02-05 2024-03-19 ヴィクィ インク. 細胞の形態学的変化の早期検出のための機械学習
CN114002133B (zh) * 2021-10-25 2023-01-24 南京大学 血清中ps阳性外泌体作为乳腺癌化疗敏感性标志物的应用
WO2023141524A2 (en) * 2022-01-19 2023-07-27 Lyndra Therapeutics, Inc. Dosage forms for gastric retention
CN114288399B (zh) * 2022-01-20 2023-10-27 武汉科技大学 一种嵌合抗原受体联合抗肿瘤药物组合物及其应用
US20230324382A1 (en) * 2022-02-01 2023-10-12 Trustees Of Tufts College Antiphospholipid antibodies for the diagnosis of lyme disease
WO2023150672A1 (en) * 2022-02-04 2023-08-10 Duke University Compositions for and methods of treating hematological cancers

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245015A (en) * 1991-04-26 1993-09-14 Tanox Biosystems, Inc. Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro
CA2058769C (en) * 1990-04-06 1999-03-02 Steven Anthony Krilis Methods for determining phospholipids and antibodies thereof
ATE175275T1 (de) * 1992-02-05 1999-01-15 Yamasa Corp Festphasenreagenz und selbiges verwendendes antikörpertestverfahren
WO1994013323A1 (en) 1992-12-04 1994-06-23 The Liposome Company, Inc. Method of inhibiting the clearance of liposomes from the circulation
FR2701319B1 (fr) * 1993-02-09 1995-04-21 Elie Stefas Procédé de détection et/ou de dosage de composés viraux et support portant une glycoprotéine.
FR2701263B1 (fr) * 1993-02-09 1995-04-21 Elie Stefas Procédé d'obtention d'une composition aqueuse protéinique, composition correspondante, glycoprotéine contenue et son utilisation pour la stabilisation de l'albumine et la détection ou le dosage d'anticorps.
US5900359A (en) * 1993-09-29 1999-05-04 Yamasa Corporation Method for determination of oxidized lipoproteins and use thereof
CA2176007A1 (en) * 1993-11-16 1995-05-26 Eiji Matsuura Method of assaying antiphospholipid antibody and kit therefor
WO1996004559A1 (fr) * 1994-08-01 1996-02-15 Institut Français De Recherches Scientifiques Pour Le Developpement En Cooperation - Orstom Procede de separation et/ou de detection et/ou de quantification de compose(s) infectieux et support pour la mise en ×uvre du procede
FR2722991B1 (fr) 1994-08-01 1996-10-11 Orstom Utilisation de la beta2-glycoproteine i sous au moins une de ses formes comme agent anti-infectueux et composition pharmaceutique corrrespondante
US5817789A (en) * 1995-06-06 1998-10-06 Transkaryotic Therapies, Inc. Chimeric proteins for use in transport of a selected substance into cells
US5874409A (en) * 1995-06-07 1999-02-23 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
US6203980B1 (en) * 1998-02-02 2001-03-20 University Of Pittsburgh Identification of apolipoprotein H mutations and their diagnostic uses
US6858210B1 (en) * 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
IL125262A0 (en) * 1998-07-07 1999-03-12 Yeda Res & Dev Synthetic peptides and pharmaceutical compositions comprising them
JP2000028607A (ja) 1998-07-10 2000-01-28 Iatron Lab Inc 新規なモノクローナル抗体及びニックβ2グリコプロテインIの免疫学的分析方法
ES2233065T3 (es) * 1998-07-13 2005-06-01 Board Of Regents, The University Of Texas System Utilizacion de anticuerpos anti-aminofosfolipidos para el tratamiento del cancer.
US6818213B1 (en) * 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
US6406693B1 (en) * 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
CA2331789C (en) * 1998-07-13 2013-09-10 Board Of Regents, The University Of Texas System Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US20050197283A1 (en) * 1998-10-04 2005-09-08 Vascular Biogenics Ltd. Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease
IL126447A (en) * 1998-10-04 2004-09-27 Vascular Biogenics Ltd An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis
US20050148499A1 (en) * 1998-10-04 2005-07-07 Dror Harats Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of atherosclerosis
AUPQ272699A0 (en) 1999-09-09 1999-09-30 Unisearch Limited Use of beta2GPI in diagnostic tests for autoimmune diseases
US7600039B2 (en) * 2000-02-16 2009-10-06 Motorola, Inc. Label-based multiplexing
CA2402211A1 (en) 2000-03-08 2001-09-13 National Jewish Medical And Research Center Phosphatidyl serine receptors and uses thereof
EP1292337A2 (en) * 2000-06-08 2003-03-19 La Jolla Pharmaceutical Multivalent platform molecules comprising high molecular weight polyethylene oxide
JP4336498B2 (ja) * 2000-12-12 2009-09-30 メディミューン,エルエルシー 延長した半減期を有する分子ならびにその組成物および用途
US20020127698A1 (en) * 2001-01-26 2002-09-12 Ralf Geiben Lynn Serpin drugs for treatment of HIV infection and method of use thereof
WO2002100445A1 (en) 2001-06-13 2002-12-19 The University Of Sydney Treatment and composition for wound healing
FR2827047B1 (fr) * 2001-07-03 2003-09-26 Apoh Technollgies Sa Procede de separation et/ou detection et/ou identification et/ou quantification de proteines prions
JP4681175B2 (ja) 2001-09-28 2011-05-11 三菱化学メディエンス株式会社 播種性血管内凝固症候群及びその発症前段階を検出する方法
JP4070443B2 (ja) * 2001-10-11 2008-04-02 株式会社三菱化学ヤトロン 脳梗塞を検出する方法
US20030100036A1 (en) * 2001-11-08 2003-05-29 Aristo Vojdani Saliva immunoassay for detection of antibodies for cardiovascular disease
AU2002361642A1 (en) * 2001-11-16 2003-06-10 The University Of Tennessee Research Corporation Recombinant antibody fusion proteins and methods for detection of apoptotic cells
US7329642B2 (en) * 2002-05-17 2008-02-12 Board Of Regents, University Of Texas System β-2-glycoprotein is an inhibitor of angiogenesis
US7906115B2 (en) * 2002-07-15 2011-03-15 Thorpe Philip E Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7247303B2 (en) * 2002-07-15 2007-07-24 Board Of Regents, The University Of Texas System Selected antibody CDRs for binding to aminophospholipids
US7615223B2 (en) * 2002-07-15 2009-11-10 Board Of Regents, The University Of Texas System Selected immunoconjugates for binding to aminophospholipids
US7611704B2 (en) * 2002-07-15 2009-11-03 Board Of Regents, The University Of Texas System Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7455833B2 (en) * 2002-07-15 2008-11-25 Board Of Regents, The University Of Texas System Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
US7625563B2 (en) * 2002-07-15 2009-12-01 Board Of Regents, The University Of Texas System Cancer treatment methods using selected immunoconjugates for binding to aminophospholipids
US7790159B2 (en) * 2002-07-15 2010-09-07 Board Of Regents, The University Of Texas System Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids
US7714109B2 (en) * 2002-07-15 2010-05-11 Board Of Regents, The University Of Texas System Combinations and kits for cancer treatment using selected antibodies to aminophospholipids
US7572448B2 (en) * 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Combined cancer treatment methods using selected antibodies to aminophospholipids
US7622118B2 (en) * 2002-07-15 2009-11-24 Board Of Regents, The University Of Texas System Cancer treatment methods using selected antibodies to aminophospholipids
DK2283868T3 (en) * 2002-07-15 2016-04-25 Univ Texas PEPTIDES BINDING TO PHOSPHATIDYLETHANOLAMINE AND ITS USE IN TREATING VIRUS INFECTIONS AND CANCER
US7678386B2 (en) * 2002-07-15 2010-03-16 Board Of Regents The University Of Texas Liposomes coated with selected antibodies that bind to aminophospholipids
ATE512364T1 (de) * 2002-08-07 2011-06-15 Ablynx Nv Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha
AU2004239244C1 (en) 2003-05-06 2015-04-23 Bioverativ Therapeutics Inc. Clotting factor-Fc chimeric proteins to treat hemophilia
US8198020B2 (en) * 2003-08-22 2012-06-12 Potentia Pharmaceuticals, Inc. Compositions and methods for enhancing phagocytosis or phagocyte activity
US20090068207A1 (en) 2005-04-15 2009-03-12 Vascular Biogenics Ltd. Compositions Containing Beta 2-Glycoprotein I-Derived Peptides for the Prevention and/or Treatment of Vascular Disease
EP1872132B1 (en) * 2005-04-18 2013-09-18 Bio-Rad Laboratories, Inc. Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment

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