SI0906094T1 - Substituted n- (aminoiminomethyl or aminomethyl)phenyl)propyl amides - Google Patents
Substituted n- (aminoiminomethyl or aminomethyl)phenyl)propyl amidesInfo
- Publication number
- SI0906094T1 SI0906094T1 SI9630629T SI9630629T SI0906094T1 SI 0906094 T1 SI0906094 T1 SI 0906094T1 SI 9630629 T SI9630629 T SI 9630629T SI 9630629 T SI9630629 T SI 9630629T SI 0906094 T1 SI0906094 T1 SI 0906094T1
- Authority
- SI
- Slovenia
- Prior art keywords
- aminoiminomethyl
- aminomethyl
- phenyl
- substituted
- propyl amides
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- C07C255/00—Carboxylic acid nitriles
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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- C07D209/04—Indoles; Hydrogenated indoles
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US948596P | 1996-01-02 | 1996-01-02 | |
PCT/US1996/020770 WO1997024118A1 (en) | 1996-01-02 | 1996-12-23 | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
EP96945304A EP0906094B1 (en) | 1996-01-02 | 1996-12-23 | Substituted n- (aminoiminomethyl or aminomethyl)phenyl]propyl amides |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0906094T1 true SI0906094T1 (en) | 2003-12-31 |
Family
ID=21737952
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9630629T SI0906094T1 (en) | 1996-01-02 | 1996-12-23 | Substituted n- (aminoiminomethyl or aminomethyl)phenyl)propyl amides |
SI9620136A SI9620136B (en) | 1996-01-02 | 1996-12-23 | Substituted n-/(aminoiminomethyl or aminomethyl)phenyl/-propyl amides |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9620136A SI9620136B (en) | 1996-01-02 | 1996-12-23 | Substituted n-/(aminoiminomethyl or aminomethyl)phenyl/-propyl amides |
Country Status (29)
Country | Link |
---|---|
US (1) | US6140504A (hu) |
EP (1) | EP0906094B1 (hu) |
JP (1) | JP4053597B2 (hu) |
KR (1) | KR100348338B1 (hu) |
CN (1) | CN1273128C (hu) |
AP (1) | AP861A (hu) |
AT (1) | ATE243512T1 (hu) |
AU (1) | AU723338B2 (hu) |
BG (1) | BG64143B1 (hu) |
BR (1) | BR9612423B1 (hu) |
CA (1) | CA2241904C (hu) |
CL (1) | CL2004000376A1 (hu) |
CZ (1) | CZ297544B6 (hu) |
DE (1) | DE69628856T2 (hu) |
DK (1) | DK0906094T3 (hu) |
EA (2) | EA001932B1 (hu) |
ES (1) | ES2197257T3 (hu) |
HK (1) | HK1017613A1 (hu) |
HU (1) | HU228355B1 (hu) |
IL (1) | IL125163A0 (hu) |
NO (1) | NO310719B1 (hu) |
OA (1) | OA10804A (hu) |
PL (1) | PL185460B1 (hu) |
PT (1) | PT906094E (hu) |
RO (1) | RO117913B1 (hu) |
SI (2) | SI0906094T1 (hu) |
SK (1) | SK284507B6 (hu) |
UA (1) | UA46821C2 (hu) |
WO (1) | WO1997024118A1 (hu) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080767A (en) * | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
ES2197257T3 (es) * | 1996-01-02 | 2004-01-01 | Aventis Pharmaceuticals Inc. | N-[(aminoiminometil o aminometil)fenil-propilamidas sustituidas. |
TW542822B (en) * | 1997-01-17 | 2003-07-21 | Ajinomoto Kk | Benzamidine derivatives |
US6620961B1 (en) * | 1997-08-26 | 2003-09-16 | Kumiai Chemical Industry Co., Ltd. | Biarylalkylenecarbamic acid derivatives and bacteriocides for agricultural and horticultural use |
US6740682B2 (en) | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
KR20010042125A (ko) * | 1998-03-23 | 2001-05-25 | 오흘러 로스 제이. | 피페리디디닐 및 n-아미디노피페리디닐 유도체 |
KR20010052694A (ko) | 1998-06-08 | 2001-06-25 | 에가시라 구니오 | 벤즈아미딘 유도체 |
US6610704B1 (en) | 1998-12-23 | 2003-08-26 | Eli Lilly And Company | Antithrombotic amides |
WO2000038683A1 (en) | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
NZ512548A (en) | 1998-12-24 | 2003-08-29 | Aventis Pharma Inc | Substituted (aminoiminomethyl or aminomethyl) benzoheteroaryl compounds, and use to inhibit Factor Xa |
EP1022268A1 (en) * | 1999-01-02 | 2000-07-26 | Aventis Pharma Deutschland GmbH | Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them |
HUP0202647A3 (en) | 1999-01-02 | 2003-12-29 | Aventis Pharma Gmbh | Arylalkanoyl derivatives, processes for their preparation, their use and pharmaceutical compositions containing them |
US6794412B1 (en) * | 1999-03-11 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Treatment of thrombosis by combined use of a factor Xa inhibitor and aspirin |
WO2000076971A2 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Serine protease inhibitors |
PL354619A1 (en) * | 1999-10-28 | 2004-02-09 | Sankyo Company, Limited | Benzamidine derivatives |
WO2001033217A2 (en) | 1999-11-02 | 2001-05-10 | Aventis Pharma Deutschland Gmbh | Monitoring the activity of factor xa inhibitors |
DE10006601A1 (de) | 2000-02-15 | 2001-08-16 | Clariant Gmbh | Verfahren zur Herstellung von 4-(4'-Carboxyphenyl)pyridin |
GB0108903D0 (en) * | 2000-10-05 | 2001-05-30 | Aventis Pharm Prod Inc | Novel crystalline forms of a factor Xa inhibitor |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
DE102006048300A1 (de) | 2006-01-26 | 2007-08-02 | Hellstern, Peter, Prof. Dr.med. | Inhibitoren des Blutgerinnungsfaktors Xa zur Verwendung als Antikoagulans |
RU2513090C2 (ru) * | 2009-04-17 | 2014-04-20 | Мерц Фарма Гмбх Унд Ко. Кгаа | Синтез мезилата 1-амино-1,3,3,5,5-пентаметилциклогексана |
NZ597957A (en) | 2009-07-29 | 2014-05-30 | Sanofi Sa | Otamixaban for treatment of elderly and renal impaired non-st elevation myocardial infarction patients |
GB0919194D0 (en) | 2009-11-02 | 2009-12-16 | Lytix Biopharma As | Compounds |
KR101844623B1 (ko) | 2011-03-29 | 2018-04-02 | 사노피 | 안정성이 향상된 오타믹사반 제제 |
CA2830965C (en) * | 2011-03-29 | 2019-04-09 | Sanofi | Benzoic acid salt of otamixaban |
EP2759533B1 (en) | 2011-09-22 | 2017-08-02 | Takeda Pharmaceutical Company Limited | Condensed heterocyclic compound |
CA2883625A1 (en) | 2012-08-31 | 2014-03-06 | Sanofi | Otamixaban for use in the treatment of non-st elevation acute coronary syndrome in patients planned to undergo coronary artery bypass grafting |
DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
US10351750B2 (en) | 2017-02-03 | 2019-07-16 | Saudi Arabian Oil Company | Drilling fluid compositions with enhanced rheology and methods of using same |
EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
ES2197257T3 (es) * | 1996-01-02 | 2004-01-01 | Aventis Pharmaceuticals Inc. | N-[(aminoiminometil o aminometil)fenil-propilamidas sustituidas. |
-
1996
- 1996-12-23 ES ES96945304T patent/ES2197257T3/es not_active Expired - Lifetime
- 1996-12-23 CA CA002241904A patent/CA2241904C/en not_active Expired - Lifetime
- 1996-12-23 JP JP52456097A patent/JP4053597B2/ja not_active Expired - Lifetime
- 1996-12-23 AU AU15207/97A patent/AU723338B2/en not_active Expired
- 1996-12-23 IL IL12516396A patent/IL125163A0/xx not_active IP Right Cessation
- 1996-12-23 KR KR10-1998-0705093A patent/KR100348338B1/ko not_active IP Right Cessation
- 1996-12-23 AP APAP/P/1998/001288A patent/AP861A/en active
- 1996-12-23 SI SI9630629T patent/SI0906094T1/xx unknown
- 1996-12-23 PT PT96945304T patent/PT906094E/pt unknown
- 1996-12-23 DE DE69628856T patent/DE69628856T2/de not_active Expired - Lifetime
- 1996-12-23 EA EA199900669A patent/EA001932B1/ru not_active IP Right Cessation
- 1996-12-23 DK DK96945304T patent/DK0906094T3/da active
- 1996-12-23 SI SI9620136A patent/SI9620136B/sl active Search and Examination
- 1996-12-23 SK SK897-98A patent/SK284507B6/sk not_active IP Right Cessation
- 1996-12-23 UA UA98074143A patent/UA46821C2/uk unknown
- 1996-12-23 EP EP96945304A patent/EP0906094B1/en not_active Expired - Lifetime
- 1996-12-23 WO PCT/US1996/020770 patent/WO1997024118A1/en active IP Right Grant
- 1996-12-23 EA EA199800620A patent/EA001280B1/ru not_active IP Right Cessation
- 1996-12-23 PL PL96327633A patent/PL185460B1/pl unknown
- 1996-12-23 BR BRPI9612423-7A patent/BR9612423B1/pt not_active IP Right Cessation
- 1996-12-23 HU HU9900930A patent/HU228355B1/hu unknown
- 1996-12-23 CZ CZ0201098A patent/CZ297544B6/cs not_active IP Right Cessation
- 1996-12-23 RO RO98-01136A patent/RO117913B1/ro unknown
- 1996-12-23 AT AT96945304T patent/ATE243512T1/de active
- 1996-12-23 CN CNB961998946A patent/CN1273128C/zh not_active Expired - Lifetime
-
1998
- 1998-06-30 NO NO19983039A patent/NO310719B1/no not_active IP Right Cessation
- 1998-07-01 OA OA9800100A patent/OA10804A/en unknown
- 1998-07-10 BG BG102619A patent/BG64143B1/bg unknown
-
1999
- 1999-07-05 HK HK99102817A patent/HK1017613A1/xx not_active IP Right Cessation
-
2000
- 2000-02-04 US US09/499,335 patent/US6140504A/en not_active Expired - Lifetime
-
2004
- 2004-02-26 CL CL200400376A patent/CL2004000376A1/es unknown
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