SI0807111T1 - Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing same - Google Patents
Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing sameInfo
- Publication number
- SI0807111T1 SI0807111T1 SI9630532T SI9630532T SI0807111T1 SI 0807111 T1 SI0807111 T1 SI 0807111T1 SI 9630532 T SI9630532 T SI 9630532T SI 9630532 T SI9630532 T SI 9630532T SI 0807111 T1 SI0807111 T1 SI 0807111T1
- Authority
- SI
- Slovenia
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- substituted heterocyclic
- method therefor
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
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- C—CHEMISTRY; METALLURGY
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- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
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- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
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- C—CHEMISTRY; METALLURGY
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- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9501016A FR2729952B1 (fr) | 1995-01-30 | 1995-01-30 | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR9508046A FR2729953B1 (fr) | 1995-01-30 | 1995-07-04 | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR9513005A FR2729954B1 (fr) | 1995-01-30 | 1995-11-03 | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
EP96902305A EP0807111B1 (fr) | 1995-01-30 | 1996-01-30 | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
PCT/FR1996/000152 WO1996023787A1 (fr) | 1995-01-30 | 1996-01-30 | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
Publications (1)
Publication Number | Publication Date |
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SI0807111T1 true SI0807111T1 (en) | 2003-02-28 |
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ID=27253013
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9630713T SI1156049T1 (en) | 1995-01-30 | 1996-01-30 | Substituted heterocyclic compounds, their process of preparation and pharmaceutical compositions containing them |
SI9630532T SI0807111T1 (en) | 1995-01-30 | 1996-01-30 | Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing same |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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SI9630713T SI1156049T1 (en) | 1995-01-30 | 1996-01-30 | Substituted heterocyclic compounds, their process of preparation and pharmaceutical compositions containing them |
Country Status (26)
Country | Link |
---|---|
US (4) | US5641777A (zh) |
EP (5) | EP0807111B1 (zh) |
JP (4) | JP3234228B2 (zh) |
CN (6) | CN1089764C (zh) |
AR (2) | AR002955A1 (zh) |
AT (2) | ATE222251T1 (zh) |
AU (1) | AU707901B2 (zh) |
CA (1) | CA2211668C (zh) |
CY (2) | CY2369B1 (zh) |
CZ (2) | CZ293134B6 (zh) |
DE (2) | DE69622992T2 (zh) |
DK (2) | DK1156049T3 (zh) |
ES (2) | ES2181866T3 (zh) |
FI (1) | FI973148A (zh) |
FR (1) | FR2729954B1 (zh) |
HU (1) | HUP9800295A3 (zh) |
IL (3) | IL116957A (zh) |
MX (1) | MX9705590A (zh) |
MY (1) | MY117527A (zh) |
NO (1) | NO308795B1 (zh) |
NZ (1) | NZ301285A (zh) |
PL (1) | PL192164B1 (zh) |
PT (2) | PT807111E (zh) |
RU (1) | RU2157807C2 (zh) |
SI (2) | SI1156049T1 (zh) |
WO (1) | WO1996023787A1 (zh) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2751654B1 (fr) * | 1996-07-26 | 1998-10-23 | Sanofi Sa | Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant |
GB9513972D0 (en) * | 1995-07-08 | 1995-09-06 | Merck Sharp & Dohme | Pharmaceutical compositions |
RU2135494C1 (ru) | 1995-12-01 | 1999-08-27 | Санкио Компани Лимитед | Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина |
GB9601680D0 (en) * | 1996-01-27 | 1996-03-27 | Pfizer Ltd | Therapeutic agents |
FR2759584B1 (fr) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | Composition pharmaceutique pour l'administration orale de composes heterocycliques sous forme ammonium quaternaire |
FR2759585B1 (fr) * | 1997-02-17 | 1999-06-11 | Sanofi Sa | Formulations pharmaceutiques presentees sous forme seche pour l'administration orale d'un compose ammonium quaternaire cyclique |
ES2202853T3 (es) | 1997-05-30 | 2004-04-01 | Sankyo Company Limited | Sales de derivados de oxido de sulfato opticamente activos. |
PT1048658E (pt) | 1997-12-04 | 2005-10-31 | Sankyo Co | Derivados heterociclicos acilados aliciclicos |
JP2002524556A (ja) * | 1998-09-11 | 2002-08-06 | メルク エンド カムパニー インコーポレーテッド | N−ベンジル−3−(4−フルオロフェニル)−1,4−オキサジン−2−オンの合成方法 |
WO2000034274A1 (fr) * | 1998-12-10 | 2000-06-15 | Sankyo Company, Limited | Derives de la cyclohexylpiperidine |
FR2787790A3 (fr) | 1998-12-23 | 2000-06-30 | Sanofi Sa | Procede de preparation du (r)-(+)-3-{1°2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl!-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates |
FR2791346B3 (fr) * | 1999-03-25 | 2001-04-27 | Sanofi Sa | Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2792199B3 (fr) | 1999-04-13 | 2001-05-18 | Sanofi Sa | Utilisation de l'osanetant pour la preparation de medicaments utiles dans le traitement des troubles de l'humeur |
FR2796069B3 (fr) * | 1999-07-09 | 2001-08-24 | Sanofi Synthelabo | Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes |
ES2340147T3 (es) * | 2001-04-12 | 2010-05-31 | Pharmacopeia, Llc | Piperidinas de arilo y biarilo usadas como antagonistas de mch. |
FR2824828B1 (fr) * | 2001-05-21 | 2005-05-20 | Sanofi Synthelabo | Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
JP2006511555A (ja) * | 2002-12-13 | 2006-04-06 | スミスクライン ビーチャム コーポレーション | Ccr5拮抗剤としての複素環式化合物 |
TW200524868A (en) * | 2003-07-31 | 2005-08-01 | Zeria Pharm Co Ltd | Benzylamine derivatives |
US7560549B2 (en) * | 2004-02-25 | 2009-07-14 | Sankyo Company, Limited | Sulfonyloxy derivatives |
AU2005231479C1 (en) * | 2004-04-05 | 2012-03-15 | Sunovion Pharmaceuticals Inc. | (R,R)-formoterol in combination with other pharmacological agents |
US7955846B2 (en) * | 2004-05-17 | 2011-06-07 | The General Hospital Corporation | Compositions comprising female germline stem cells and methods of use thereof |
GB0412865D0 (en) * | 2004-06-09 | 2004-07-14 | Glaxo Group Ltd | Chemical compounds |
DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
FR2873373B1 (fr) * | 2004-07-23 | 2006-09-08 | Sanofi Synthelabo | Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique |
JP5486928B2 (ja) | 2007-02-26 | 2014-05-07 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1のサイクリックウレアおよびカルバメートインヒビター |
CA2697168A1 (en) | 2007-07-26 | 2009-02-05 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
WO2009075835A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceutical, Inc | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 |
TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
JP5490020B2 (ja) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状カルバゼート及びセミカルバジドインヒビター |
WO2009102428A2 (en) | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
JP5730021B2 (ja) | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤としてのシクロアルキルラクタム誘導体 |
CA2718264A1 (en) * | 2008-03-18 | 2009-09-24 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
CL2009001058A1 (es) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
EP2291373B1 (en) | 2008-05-01 | 2013-09-11 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
NZ588954A (en) | 2008-05-01 | 2012-08-31 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
US8592410B2 (en) | 2008-05-01 | 2013-11-26 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1 |
JP5390610B2 (ja) | 2008-07-25 | 2014-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型の阻害剤の合成 |
TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
ES2432150T3 (es) | 2008-07-25 | 2013-12-02 | Boehringer Ingelheim International Gmbh | Inhibidores cíclicos de la 11 beta-hidroxiesteroide deshidrogenasa 1 |
US8637505B2 (en) | 2009-02-04 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW201039034A (en) * | 2009-04-27 | 2010-11-01 | Chunghwa Picture Tubes Ltd | Pixel structure and the method of forming the same |
US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
GEP20156309B (en) * | 2009-04-30 | 2015-07-10 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
JP5749263B2 (ja) | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
WO2011056737A1 (en) | 2009-11-05 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Novel chiral phosphorus ligands |
BR112012014899A2 (pt) | 2009-12-18 | 2017-03-14 | Idenix Pharmaceuticals Inc | composto, composição farmacêutica, método para tratar ou prevenir uma infecção por vírus de hepatite c em um sujeito, método para tratar , prevenir ou melhorar um ou mais sintomas de uma doença hepática ou distúrbio associado a uma infecção por vírus de hepatite c em um sujeito, método para inibir a replicação de um vírus em um hospedeiro, método para inibir a replicação de um vírus |
JP5661791B2 (ja) | 2010-03-11 | 2015-01-28 | 大日本住友製薬株式会社 | N−アシル環状アミン誘導体またはその医薬上許容される塩 |
WO2011149822A1 (en) | 2010-05-26 | 2011-12-01 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
JP5860042B2 (ja) | 2010-06-16 | 2016-02-16 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 置換5、6及び7員複素環、そのような化合物を含有する医薬及びそれらの使用 |
WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
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US2382285A (en) * | 1941-11-19 | 1945-08-14 | Roche Products Ltd | Manufacture of arylacetonitrile derivatives |
US2513346A (en) * | 1948-12-21 | 1950-07-04 | Parke Davis & Co | Process for obtaining organic amino diols |
US2689852A (en) * | 1951-11-03 | 1954-09-21 | Hoffmann La Roche | Pyridine derivatives |
US3112311A (en) * | 1957-04-05 | 1963-11-26 | Geigy Chem Corp | 2-phenyl-5, 6-dimethyl-morpholines and 2-phenyl-5, 6-tetramethylene-morpholines |
CH436295A (de) * | 1961-11-13 | 1967-05-31 | Mcneilab Inc | Verfahren zur Herstellung neuer 3-Morpholinone |
GB8807921D0 (en) | 1988-04-05 | 1988-05-05 | Fujisawa Pharmaceutical Co | Ws-9326 & its derivatives |
DE58902057D1 (de) | 1988-08-12 | 1992-09-17 | Volkswagen Ag | Reibungskupplung. |
WO1990005525A1 (en) | 1988-11-23 | 1990-05-31 | Pfizer Inc. | Quinuclidine derivatives as substance p antagonists |
FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
FR2654726B1 (fr) | 1989-11-23 | 1992-02-14 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolone et leur preparation. |
UA41251C2 (uk) * | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
US5332817A (en) * | 1990-01-04 | 1994-07-26 | Pfizer Inc. | 3-aminopiperidine derivatives and related nitrogen containing heterocycles |
WO1991018899A1 (en) | 1990-06-01 | 1991-12-12 | Pfizer Inc. | 3-amino-2-aryl quinuclidines, process for their preparation and pharmaceutical compositions containing them |
IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2688219B1 (fr) * | 1992-03-03 | 1994-07-08 | Sanofi Elf | Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant. |
IL106142A (en) * | 1992-06-29 | 1997-03-18 | Merck & Co Inc | Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them |
FR2696178B1 (fr) * | 1992-09-30 | 1994-12-30 | Sanofi Elf | Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant. |
HU224496B1 (hu) * | 1993-05-06 | 2005-10-28 | Merrel Dow Pharmaceuticals Inc. | Pirrolidin-3-il-alkil-piperidin-származékok és e vegyületeket tartalmazó gyógyászati készítmények |
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1995
- 1995-11-03 FR FR9513005A patent/FR2729954B1/fr not_active Expired - Fee Related
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1996
- 1996-01-26 MY MYPI96000294A patent/MY117527A/en unknown
- 1996-01-29 AR ARP960101182A patent/AR002955A1/es active IP Right Grant
- 1996-01-30 IL IL11695796A patent/IL116957A/xx not_active IP Right Cessation
- 1996-01-30 US US08/593,938 patent/US5641777A/en not_active Expired - Lifetime
- 1996-01-30 PT PT96902305T patent/PT807111E/pt unknown
- 1996-01-30 ES ES96902305T patent/ES2181866T3/es not_active Expired - Lifetime
- 1996-01-30 CN CN96191686A patent/CN1089764C/zh not_active Expired - Fee Related
- 1996-01-30 PL PL321640A patent/PL192164B1/pl not_active IP Right Cessation
- 1996-01-30 SI SI9630713T patent/SI1156049T1/xx unknown
- 1996-01-30 SI SI9630532T patent/SI0807111T1/xx unknown
- 1996-01-30 AT AT96902305T patent/ATE222251T1/de active
- 1996-01-30 PT PT01119949T patent/PT1156049E/pt unknown
- 1996-01-30 NZ NZ301285A patent/NZ301285A/xx not_active IP Right Cessation
- 1996-01-30 IL IL12711496A patent/IL127114A/en not_active IP Right Cessation
- 1996-01-30 EP EP96902305A patent/EP0807111B1/fr not_active Expired - Lifetime
- 1996-01-30 CN CNB200310119883XA patent/CN1293063C/zh not_active Expired - Fee Related
- 1996-01-30 IL IL11605796A patent/IL116957A0/xx unknown
- 1996-01-30 EP EP03012771A patent/EP1340754A1/fr not_active Withdrawn
- 1996-01-30 EP EP01119949A patent/EP1156049B1/fr not_active Expired - Lifetime
- 1996-01-30 CN CNB2004100929315A patent/CN1295221C/zh not_active Expired - Fee Related
- 1996-01-30 DK DK01119949T patent/DK1156049T3/da active
- 1996-01-30 DK DK96902305T patent/DK0807111T3/da active
- 1996-01-30 EP EP06005775A patent/EP1688416A1/fr not_active Withdrawn
- 1996-01-30 DE DE69622992T patent/DE69622992T2/de not_active Expired - Lifetime
- 1996-01-30 CA CA002211668A patent/CA2211668C/en not_active Expired - Fee Related
- 1996-01-30 WO PCT/FR1996/000152 patent/WO1996023787A1/fr active IP Right Grant
- 1996-01-30 RU RU97114938/04A patent/RU2157807C2/ru not_active IP Right Cessation
- 1996-01-30 DE DE69634806T patent/DE69634806T2/de not_active Expired - Lifetime
- 1996-01-30 AT AT01119949T patent/ATE296823T1/de active
- 1996-01-30 CZ CZ19972436A patent/CZ293134B6/cs not_active IP Right Cessation
- 1996-01-30 EP EP07150446A patent/EP1923391A1/fr not_active Withdrawn
- 1996-01-30 MX MX9705590A patent/MX9705590A/es not_active IP Right Cessation
- 1996-01-30 AU AU46669/96A patent/AU707901B2/en not_active Ceased
- 1996-01-30 JP JP52330896A patent/JP3234228B2/ja not_active Expired - Lifetime
- 1996-01-30 ES ES01119949T patent/ES2243373T3/es not_active Expired - Lifetime
- 1996-01-30 CZ CZ20022243A patent/CZ294267B6/cs not_active IP Right Cessation
- 1996-01-30 HU HU9800295A patent/HUP9800295A3/hu unknown
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1997
- 1997-03-18 US US08/820,716 patent/US5869663A/en not_active Expired - Lifetime
- 1997-07-29 FI FI973148A patent/FI973148A/fi not_active Application Discontinuation
- 1997-07-29 NO NO973479A patent/NO308795B1/no not_active IP Right Cessation
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1998
- 1998-10-20 US US09/175,331 patent/US6242637B1/en not_active Expired - Fee Related
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2000
- 2000-11-09 JP JP2000342606A patent/JP2001131171A/ja active Pending
- 2000-11-09 JP JP2000342571A patent/JP3357660B2/ja not_active Expired - Lifetime
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2001
- 2001-04-11 CN CNB011163410A patent/CN1179954C/zh not_active Expired - Fee Related
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2002
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2003
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2005
- 2005-08-02 CY CY0500044A patent/CY2537B1/xx unknown
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