SI0736532T1 - Pyrido(3,2-e)pyrazinones with antiasthmatic activity and process for their preparation - Google Patents

Pyrido(3,2-e)pyrazinones with antiasthmatic activity and process for their preparation

Info

Publication number
SI0736532T1
SI0736532T1 SI9630473T SI9630473T SI0736532T1 SI 0736532 T1 SI0736532 T1 SI 0736532T1 SI 9630473 T SI9630473 T SI 9630473T SI 9630473 T SI9630473 T SI 9630473T SI 0736532 T1 SI0736532 T1 SI 0736532T1
Authority
SI
Slovenia
Prior art keywords
pyrazinones
pyrido
preparation
antiasthmatic activity
antiasthmatic
Prior art date
Application number
SI9630473T
Other languages
English (en)
Slovenian (sl)
Inventor
Norbert Dr. H�fgen
Thomas Dr. B�chner
Ute Dr. Achterrath-Tuckermann
Stefan Prof. Szelenyi
Bernhard Prof. Kutscher
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of SI0736532T1 publication Critical patent/SI0736532T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI9630473T 1995-03-24 1996-03-12 Pyrido(3,2-e)pyrazinones with antiasthmatic activity and process for their preparation SI0736532T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19510965A DE19510965A1 (de) 1995-03-24 1995-03-24 Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung
EP96103855A EP0736532B1 (de) 1995-03-24 1996-03-12 Pyrido(3,2-e)pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
SI0736532T1 true SI0736532T1 (en) 2002-08-31

Family

ID=7757727

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630473T SI0736532T1 (en) 1995-03-24 1996-03-12 Pyrido(3,2-e)pyrazinones with antiasthmatic activity and process for their preparation

Country Status (30)

Country Link
US (1) US5723463A (pl)
EP (1) EP0736532B1 (pl)
JP (1) JP4124280B2 (pl)
KR (1) KR100401395B1 (pl)
CN (1) CN1058968C (pl)
AR (1) AR002039A1 (pl)
AT (1) ATE217624T1 (pl)
AU (1) AU697908B2 (pl)
BR (1) BR9601093A (pl)
CA (1) CA2172472C (pl)
CZ (1) CZ290784B6 (pl)
DE (2) DE19510965A1 (pl)
DK (1) DK0736532T3 (pl)
ES (1) ES2174989T3 (pl)
HR (1) HRP960129B1 (pl)
HU (1) HUP9600731A3 (pl)
IL (1) IL117621A (pl)
MX (1) MX9601069A (pl)
NO (1) NO307091B1 (pl)
NZ (1) NZ286232A (pl)
PL (1) PL184800B1 (pl)
PT (1) PT736532E (pl)
RU (1) RU2143433C1 (pl)
SG (1) SG43249A1 (pl)
SI (1) SI0736532T1 (pl)
SK (1) SK36596A3 (pl)
TR (1) TR199600217A2 (pl)
TW (1) TW426682B (pl)
UA (1) UA45319C2 (pl)
ZA (1) ZA962270B (pl)

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CZ20012627A3 (cs) * 1999-01-20 2002-01-16 Arzneimittelwerk Dresden Gmbh Pouľití imidazo [1,5-a] pyrido [3,2-e]pyrazinonů jako léčiva
PT1212089E (pt) 1999-08-21 2006-08-31 Altana Pharma Ag Combinacao sinergica de roflumilast e salmeterol
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
US6465465B1 (en) 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
EP2489667B1 (en) * 2006-12-13 2015-04-15 ASKA Pharmaceutical Co., Ltd. Quinoxaline derivative
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
JP5433579B2 (ja) * 2007-09-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． １，３−二置換−４−フェニル−１ｈ−ピリジン−２−オン
PT2203439E (pt) 2007-09-14 2011-02-11 Ortho Mcneil Janssen Pharm 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas
AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
WO2009070584A1 (en) 2007-11-30 2009-06-04 Wyeth Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
CA2706986A1 (en) * 2007-11-30 2009-06-04 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
RU2510396C2 (ru) 2008-09-02 2014-03-27 Янссен Фармасьютикалз, Инк. 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов
WO2010043396A1 (en) 2008-10-16 2010-04-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
AU2009319387B2 (en) 2008-11-28 2012-05-10 Addex Pharma S.A. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
WO2010130422A1 (en) 2009-05-12 2010-11-18 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
NZ596078A (en) 2009-05-12 2013-06-28 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
US8993591B2 (en) 2010-11-08 2015-03-31 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
EP3431106B1 (en) 2014-01-21 2020-12-30 Janssen Pharmaceutica NV Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도

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US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5166344A (en) * 1989-05-31 1992-11-24 Berlex Laboratories, Inc. Process for the preparation of imidazoquinoxalinones
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
CA2110942A1 (en) * 1991-06-14 1992-12-23 Pharmacia & Upjohn Company Llc Imidazo¬1,5-a|quinoxalines
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
JP3252484B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ４，５−ジヒドロ［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体の製造方法
JP3252483B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ３環性トリアゾロ誘導体の製造方法
DE4329970A1 (de) * 1993-03-31 1994-10-06 Basf Ag Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung
FR2704547B1 (fr) * 1993-04-30 1995-06-09 Adir Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
WO1994026746A1 (en) * 1993-05-06 1994-11-24 Novo Nordisk A/S [1,2,4]TRIAZOLO[4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE
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Also Published As

Publication number Publication date
CN1058968C (zh) 2000-11-29
DK0736532T3 (da) 2002-09-02
SK36596A3 (en) 1997-02-05
MX9601069A (es) 1997-02-28
DE59609201D1 (de) 2002-06-20
CN1140173A (zh) 1997-01-15
HUP9600731A3 (en) 1997-04-28
TR199600217A2 (tr) 1996-10-21
HU9600731D0 (en) 1996-05-28
ATE217624T1 (de) 2002-06-15
CZ290784B6 (cs) 2002-10-16
AU697908B2 (en) 1998-10-22
PL313434A1 (en) 1996-09-30
RU2143433C1 (ru) 1999-12-27
DE19510965A1 (de) 1996-09-26
IL117621A0 (en) 1996-07-23
SG43249A1 (en) 1997-10-17
EP0736532A1 (de) 1996-10-09
HUP9600731A2 (en) 1997-01-28
US5723463A (en) 1998-03-03
ES2174989T3 (es) 2002-11-16
CA2172472A1 (en) 1996-09-25
KR960034204A (ko) 1996-10-22
HRP960129B1 (en) 2002-12-31
NO961173L (no) 1996-09-25
PT736532E (pt) 2002-10-31
UA45319C2 (uk) 2002-04-15
ZA962270B (en) 1996-09-30
AR002039A1 (es) 1998-01-07
NO307091B1 (no) 2000-02-07
HRP960129A2 (en) 1997-08-31
CZ74796A3 (en) 1996-10-16
IL117621A (en) 1999-05-09
PL184800B1 (pl) 2002-12-31
EP0736532B1 (de) 2002-05-15
JPH08269059A (ja) 1996-10-15
NO961173D0 (no) 1996-03-22
TW426682B (en) 2001-03-21
JP4124280B2 (ja) 2008-07-23
CA2172472C (en) 2000-01-18
AU4825796A (en) 1996-10-03
KR100401395B1 (ko) 2003-12-24
BR9601093A (pt) 1998-01-06
NZ286232A (en) 1996-10-28

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