SG55069A1 - Compounds with growth hormone releasing properties - Google Patents
Compounds with growth hormone releasing propertiesInfo
- Publication number
- SG55069A1 SG55069A1 SG1996004604A SG1996004604A SG55069A1 SG 55069 A1 SG55069 A1 SG 55069A1 SG 1996004604 A SG1996004604 A SG 1996004604A SG 1996004604 A SG1996004604 A SG 1996004604A SG 55069 A1 SG55069 A1 SG 55069A1
- Authority
- SG
- Singapore
- Prior art keywords
- growth hormone
- compounds
- hormone releasing
- releasing properties
- pct
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 230000003578 releasing effect Effects 0.000 title 1
- 230000001817 pituitary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK143993A DK143993D0 (ru) | 1993-12-23 | 1993-12-23 | |
DK12194 | 1994-01-28 | ||
DK119194 | 1994-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG55069A1 true SG55069A1 (en) | 1998-12-21 |
Family
ID=27220421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996004604A SG55069A1 (en) | 1993-12-23 | 1994-12-22 | Compounds with growth hormone releasing properties |
Country Status (27)
Country | Link |
---|---|
US (1) | US5767085A (ru) |
EP (1) | EP0736039B1 (ru) |
JP (1) | JP3181918B2 (ru) |
KR (1) | KR100354897B1 (ru) |
CN (1) | CN1052731C (ru) |
AT (1) | ATE197158T1 (ru) |
AU (1) | AU689181B2 (ru) |
BR (1) | BR9408377A (ru) |
CA (1) | CA2179597A1 (ru) |
CZ (1) | CZ293113B6 (ru) |
DE (1) | DE69426206T2 (ru) |
DK (1) | DK0736039T3 (ru) |
ES (1) | ES2153469T3 (ru) |
FI (1) | FI962584A (ru) |
GR (1) | GR3035150T3 (ru) |
HU (1) | HU224345B1 (ru) |
IL (1) | IL112112A (ru) |
MX (1) | MX9500072A (ru) |
NO (1) | NO315561B1 (ru) |
NZ (1) | NZ277486A (ru) |
PL (1) | PL181280B1 (ru) |
PT (1) | PT736039E (ru) |
RO (1) | RO115635B1 (ru) |
SG (1) | SG55069A1 (ru) |
SK (1) | SK281963B6 (ru) |
UA (1) | UA42747C2 (ru) |
WO (1) | WO1995017423A1 (ru) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
CN1052730C (zh) * | 1993-12-23 | 2000-05-24 | 诺沃挪第克公司 | 具有生长激素释放特性的化合物 |
US5798337A (en) * | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
US20020111461A1 (en) | 1999-05-21 | 2002-08-15 | Todd C. Somers | Low molecular weight peptidomimetic growth hormone secretagogues |
CA2211381C (en) * | 1995-01-27 | 2009-05-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
CA2224434A1 (en) * | 1995-06-22 | 1997-01-09 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6531314B1 (en) | 1996-12-10 | 2003-03-11 | Merck & Co., Inc. | Growth hormone secretagogue receptor family |
US6242199B1 (en) | 1995-12-13 | 2001-06-05 | Merck & Co., Inc. | Assays for growth hormone secretagogue receptors |
GB2308362A (en) * | 1995-12-19 | 1997-06-25 | Lilly Industries Ltd | Pharmaceutical indole derivatives |
CZ195098A3 (cs) * | 1995-12-22 | 1998-10-14 | Novo Nordisk A/S | Sloučeniny uvolňující růstový hormon |
US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
EP0907643B1 (en) * | 1996-04-24 | 2003-01-15 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US5919777A (en) * | 1996-04-24 | 1999-07-06 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
ATE304528T1 (de) * | 1996-07-22 | 2005-09-15 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
AU3938797A (en) * | 1996-08-29 | 1998-03-19 | Novo Nordisk A/S | Transdermal delivery of peptides |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6127341A (en) * | 1997-06-20 | 2000-10-03 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
JP4116097B2 (ja) | 1997-06-20 | 2008-07-09 | ノボ ノルディスク アクティーゼルスカブ | 成長ホルモン放出特性をもつ化合物 |
ATE281467T1 (de) | 1998-01-16 | 2004-11-15 | Novo Nordisk As | Verbindungen mit wachstumshormon-freisetzenden eigenschaften |
US6919315B1 (en) | 1998-06-30 | 2005-07-19 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US6682908B1 (en) | 1998-07-10 | 2004-01-27 | Merck & Co., Inc. | Mouse growth hormone secretagogue receptor |
CA2333857A1 (en) | 1998-07-13 | 2000-01-20 | Merck & Co., Inc. | Growth hormone secretagogue related receptors and nucleic acids |
EP1112282A4 (en) | 1998-08-10 | 2002-10-31 | Merck & Co Inc | RECEPTOR OF THE GROWTH HORMONE SECRETION PROMOTER FROM THE DOG |
US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
DE60016560T2 (de) | 1999-01-06 | 2005-12-15 | Genentech, Inc., South San Francisco | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
WO2000048623A1 (en) | 1999-02-18 | 2000-08-24 | Kaken Pharmaceutical Co., Ltd. | Novel amide derivatives as growth hormone secretagogues |
JP2003501394A (ja) * | 1999-06-04 | 2003-01-14 | ノボ ノルディスク アクティーゼルスカブ | 延長された重度の疾患の異化状態の処理のための組成物 |
ES2301547T3 (es) | 2000-05-16 | 2008-07-01 | Genentech, Inc. | Tratamiento de trastornos del cartilago. |
EP1159964B1 (en) | 2000-05-31 | 2009-10-28 | Pfizer Products Inc. | Use of growth hormone secretagogues for stimulating gastrointestinal motility |
TWI331922B (en) | 2002-08-09 | 2010-10-21 | Ipsen Pharma Sas | Growth hormone releasing peptides |
US20040234591A1 (en) * | 2003-05-19 | 2004-11-25 | Takahisa Takubo | Hard gelatin capsule and process for producing the same |
US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
HUE027218T2 (en) | 2003-09-12 | 2016-10-28 | Ipsen Biopharmaceuticals Inc | Methods for Treatment of IGF-1 (Insulin-like Growth Factor 1) Deficiency |
WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
WO2005097261A1 (en) * | 2004-03-30 | 2005-10-20 | Sapphire Therapeutics, Inc. | Method of reducing c-reactive protein using growth hormone secretagogues |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
AU2005272598B2 (en) * | 2004-08-12 | 2011-11-17 | Helsinn Therapeutics (U.S.), Inc. | Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues |
CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
EP2021015A2 (en) * | 2006-04-28 | 2009-02-11 | The Administrators Of The Tulane Educational Fund | Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof |
EP2644618B1 (en) | 2007-02-09 | 2016-08-17 | Ocera Therapeutics, Inc. | tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators |
AU2008216789A1 (en) * | 2007-02-13 | 2008-08-21 | Helsinn Therapeutics (U.S.), Inc. | Method of treating cell proliferative disorders using growth hormone secretagogues |
TWI429436B (zh) * | 2007-04-10 | 2014-03-11 | Helsinn Therapeutics Us Inc | 使用生長激素促泌素治療或預防嘔吐之方法 |
EP2155769B1 (en) | 2007-05-04 | 2012-06-27 | Katholieke Universiteit Leuven KU Leuven Research & Development | Tissue degeneration protection |
US8466151B2 (en) | 2007-12-26 | 2013-06-18 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
CA2999321A1 (en) | 2008-07-17 | 2010-01-21 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
UA105657C2 (ru) | 2009-02-27 | 2014-06-10 | Хелсінн Терапьютікс (Ю.Ес.), Інк. | Улучшенные способы лечения мигрени на основе анаморелина |
US9724381B2 (en) | 2009-05-12 | 2017-08-08 | The Administrators Of The Tulane Educational Fund | Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof |
KR20120030530A (ko) * | 2009-06-12 | 2012-03-28 | 헬신 세라퓨틱스 (유.에스.) 인크. | 이파모렐린 디아세테이트 주사 및 주입 용액 |
CA2999435A1 (en) | 2010-04-01 | 2011-10-06 | Critical Outcome Technologies Inc. | Compounds and method for treatment of hiv |
WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
JP6649902B2 (ja) | 2014-05-30 | 2020-02-19 | ファイザー・インク | 選択的アンドロゲン受容体モジュレーターとしてのカルボニトリル誘導体 |
WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
WO2018183411A1 (en) | 2017-03-28 | 2018-10-04 | The Regents Of The University Of Michigan | Small molecule dcn1 inhibitors and therapeutic methods using the same |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4223020A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4228156A (en) * | 1979-03-30 | 1980-10-14 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4223019A (en) * | 1979-03-30 | 1980-09-16 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US4410512A (en) * | 1981-12-28 | 1983-10-18 | Beckman Instruments, Inc. | Combinations having synergistic pituitary growth hormone releasing activity |
JPS58501861A (ja) * | 1981-12-28 | 1983-11-04 | ベツクマン・インストルメンツ・インコ−ポレ−テツド | 下垂体成長ホルモン放出活性を有する合成ペプチド |
US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
IL98910A0 (en) * | 1990-07-24 | 1992-07-15 | Polygen Holding Corp | Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them |
US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
JPH08502250A (ja) * | 1992-09-25 | 1996-03-12 | スミスクライン・ビーチャム・コーポレイション | 成長ホルモン放出ペプチド |
WO1995014666A1 (en) * | 1993-11-24 | 1995-06-01 | Merck & Co., Inc. | Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s) |
-
1994
- 1994-12-22 KR KR1019960703336A patent/KR100354897B1/ko not_active IP Right Cessation
- 1994-12-22 PT PT95903774T patent/PT736039E/pt unknown
- 1994-12-22 DE DE69426206T patent/DE69426206T2/de not_active Expired - Lifetime
- 1994-12-22 DK DK95903774T patent/DK0736039T3/da active
- 1994-12-22 CA CA002179597A patent/CA2179597A1/en not_active Abandoned
- 1994-12-22 US US08/448,623 patent/US5767085A/en not_active Expired - Lifetime
- 1994-12-22 EP EP95903774A patent/EP0736039B1/en not_active Expired - Lifetime
- 1994-12-22 RO RO96-01293A patent/RO115635B1/ro unknown
- 1994-12-22 PL PL94315113A patent/PL181280B1/pl not_active IP Right Cessation
- 1994-12-22 JP JP51710995A patent/JP3181918B2/ja not_active Expired - Lifetime
- 1994-12-22 BR BR9408377A patent/BR9408377A/pt not_active Application Discontinuation
- 1994-12-22 UA UA96062486A patent/UA42747C2/ru unknown
- 1994-12-22 ES ES95903774T patent/ES2153469T3/es not_active Expired - Lifetime
- 1994-12-22 IL IL11211294A patent/IL112112A/xx not_active IP Right Cessation
- 1994-12-22 WO PCT/DK1994/000485 patent/WO1995017423A1/en active IP Right Grant
- 1994-12-22 CN CN94194590A patent/CN1052731C/zh not_active Expired - Fee Related
- 1994-12-22 SK SK820-96A patent/SK281963B6/sk unknown
- 1994-12-22 HU HU9501947A patent/HU224345B1/hu not_active IP Right Cessation
- 1994-12-22 AT AT95903774T patent/ATE197158T1/de not_active IP Right Cessation
- 1994-12-22 CZ CZ19961834A patent/CZ293113B6/cs not_active IP Right Cessation
- 1994-12-22 NZ NZ277486A patent/NZ277486A/en unknown
- 1994-12-22 AU AU12724/95A patent/AU689181B2/en not_active Ceased
- 1994-12-22 SG SG1996004604A patent/SG55069A1/en unknown
-
1995
- 1995-01-02 MX MX9500072A patent/MX9500072A/es unknown
-
1996
- 1996-06-20 FI FI962584A patent/FI962584A/fi not_active IP Right Cessation
- 1996-06-21 NO NO19962665A patent/NO315561B1/no not_active IP Right Cessation
-
2000
- 2000-12-27 GR GR20000402838T patent/GR3035150T3/el not_active IP Right Cessation
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