SG173397A1 - Compositions and methods for the treatment of mucositis - Google Patents

Info

Publication number

SG173397A1

SG173397A1 SG2011052230A SG2011052230A SG173397A1 SG 173397 A1 SG173397 A1 SG 173397A1 SG 2011052230 A SG2011052230 A SG 2011052230A SG 2011052230 A SG2011052230 A SG 2011052230A SG 173397 A1 SG173397 A1 SG 173397A1

Authority

SG

Singapore

Prior art keywords

compound

formula

alkyl

compounds

formulae

Prior art date

2006-07-19

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• 238000000034 method Methods 0.000 title claims abstract description 63
• 239000000203 mixture Substances 0.000 title claims abstract description 50
• 206010028116 Mucosal inflammation Diseases 0.000 title claims abstract description 43
• 201000010927 Mucositis Diseases 0.000 title claims abstract description 43
• 238000011282 treatment Methods 0.000 title abstract description 31
• 150000001875 compounds Chemical class 0.000 claims abstract description 200
• -1 lipoxin compound Chemical class 0.000 claims abstract description 124
• 229930184725 Lipoxin Natural products 0.000 claims abstract description 39
• KFINXCASWPGHEW-UHFFFAOYSA-N (9S*,10R*,11R*,12Z,15Z)-9,10,11-trihydroxyoctadeca-12,15-dienoic acid Natural products CCC=CCC=CC(O)C(O)C(O)CCCCCCCC(O)=O KFINXCASWPGHEW-UHFFFAOYSA-N 0.000 claims abstract description 28
• 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 41
• 150000003839 salts Chemical class 0.000 claims description 40
• 229940012843 omega-3 fatty acid Drugs 0.000 claims description 38
• CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 34
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 32
• 229960001138 acetylsalicylic acid Drugs 0.000 claims description 32
• 239000003814 drug Substances 0.000 claims description 22
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• 238000002360 preparation method Methods 0.000 claims description 8
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• 238000011285 therapeutic regimen Methods 0.000 claims description 5
• 230000036269 ulceration Effects 0.000 claims description 5
• 238000011161 development Methods 0.000 claims description 4
• 230000017074 necrotic cell death Effects 0.000 claims description 4
• 210000004400 mucous membrane Anatomy 0.000 claims description 3
• 230000001737 promoting effect Effects 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 description 94
• 125000003118 aryl group Chemical group 0.000 description 69
• 229910052739 hydrogen Inorganic materials 0.000 description 66
• 125000001072 heteroaryl group Chemical group 0.000 description 62
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• 125000004432 carbon atom Chemical group C* 0.000 description 48
• 125000003342 alkenyl group Chemical group 0.000 description 42
• 125000003545 alkoxy group Chemical group 0.000 description 40
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• 125000001424 substituent group Chemical group 0.000 description 39
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• 125000000623 heterocyclic group Chemical group 0.000 description 33
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• 125000001183 hydrocarbyl group Chemical group 0.000 description 22
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• 125000004414 alkyl thio group Chemical group 0.000 description 11
• 125000004122 cyclic group Chemical group 0.000 description 11
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• 229910052717 sulfur Inorganic materials 0.000 description 11
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• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 10
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