SG152239A1 - Compounds for proteasome enzyme inhibition - Google Patents

Compounds for proteasome enzyme inhibition

Info

Publication number
SG152239A1
SG152239A1 SG200902548-7A SG2009025487A SG152239A1 SG 152239 A1 SG152239 A1 SG 152239A1 SG 2009025487 A SG2009025487 A SG 2009025487A SG 152239 A1 SG152239 A1 SG 152239A1
Authority
SG
Singapore
Prior art keywords
compounds
enzyme inhibition
proteasome enzyme
proteasome
inhibition
Prior art date
Application number
SG200902548-7A
Other languages
English (en)
Inventor
Mark S Smyth
Guy J Laidig
Ronald T Borchardt
Barry A Bunin
Craig M Crews
John H Musser
Original Assignee
Proteolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34965899&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG152239(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Proteolix Inc filed Critical Proteolix Inc
Publication of SG152239A1 publication Critical patent/SG152239A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
SG200902548-7A 2004-04-15 2005-04-14 Compounds for proteasome enzyme inhibition SG152239A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US56234004P 2004-04-15 2004-04-15
US56909604P 2004-05-07 2004-05-07
US59940104P 2004-08-06 2004-08-06
US61000204P 2004-09-14 2004-09-14
US61015904P 2004-09-14 2004-09-14
US61000104P 2004-09-14 2004-09-14
US62057304P 2004-10-20 2004-10-20

Publications (1)

Publication Number Publication Date
SG152239A1 true SG152239A1 (en) 2009-05-29

Family

ID=34965899

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012076659A SG185306A1 (en) 2004-04-15 2005-04-14 Compounds for proteasome enzyme inhibition
SG200902548-7A SG152239A1 (en) 2004-04-15 2005-04-14 Compounds for proteasome enzyme inhibition

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012076659A SG185306A1 (en) 2004-04-15 2005-04-14 Compounds for proteasome enzyme inhibition

Country Status (17)

Country Link
US (9) US8129346B2 (de)
EP (1) EP1745064B1 (de)
JP (3) JP5616569B2 (de)
CN (2) CN102174076A (de)
AT (1) ATE494298T1 (de)
AU (1) AU2005238445B2 (de)
BR (1) BRPI0509879A (de)
CA (1) CA2562411A1 (de)
CY (1) CY1117244T1 (de)
DE (1) DE602005025750D1 (de)
DK (1) DK1745064T3 (de)
HK (1) HK1097860A1 (de)
IL (3) IL178400A (de)
PL (1) PL1745064T3 (de)
PT (1) PT1745064E (de)
SG (2) SG185306A1 (de)
WO (1) WO2005105827A2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198270B2 (en) 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
PL1745064T3 (pl) * 2004-04-15 2011-06-30 Onyx Therapeutics Inc Związki do hamowania enzymu proteazomu
AU2012203602B2 (en) * 2004-04-15 2015-08-27 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
US7232818B2 (en) * 2004-04-15 2007-06-19 Proteolix, Inc. Compounds for enzyme inhibition
CA2565407A1 (en) 2004-05-10 2005-11-24 Proteolix, Inc. Compounds for enzyme inhibition
PT2260835E (pt) * 2004-12-07 2013-05-28 Onyx Therapeutics Inc Composição para inibição do proteassoma
CN105237621A (zh) 2005-11-09 2016-01-13 欧尼斯治疗公司 用于酶抑制的化合物
MX2008016512A (es) 2006-06-19 2009-02-26 Proteolix Inc Epoxicetonas peptidicas para la inhibicion del proteasoma.
CL2008002966A1 (es) 2007-10-04 2010-06-25 Onyx Therapeutics Inc Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros.
AP2011005690A0 (en) 2008-10-21 2011-06-30 Onyx Therapeutics Inc Combination therapy with peptide epoxyketones.
PT2408802T (pt) 2009-03-16 2017-08-03 Governing Council Univ Toronto Moléculas de aminoácido ciclicas e métodos para as preparar
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
GB0914883D0 (en) 2009-08-26 2009-09-30 Univ Belfast Compound
JP5919196B2 (ja) 2009-11-13 2016-05-18 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 転移抑制のためのペプチドエポキシケトンの使用
EA201290844A1 (ru) 2010-03-01 2013-03-29 Оникс Терапьютикс, Инк. Соединения для ингибирования иммунопротеасом
KR20130094185A (ko) 2010-04-07 2013-08-23 오닉스 세라퓨틱스, 인크. 결정성 펩티드 에폭시케톤 면역프로테아좀 저해제
FI2662094T3 (fi) * 2012-05-08 2024-06-26 Onyx Therapeutics Inc Syklodekstriinin kompleksointimenetelmiä peptidiproteasomiestäjien formulointiin
EP2869820A4 (de) * 2012-07-09 2016-02-17 Onyx Therapeutics Inc Prodrugs von peptidepoxidketonproteaseinhibitoren
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
CN105407921A (zh) 2013-03-13 2016-03-16 赛诺菲 包含抗cd38抗体和卡非佐米的组合物
CA2918530C (en) 2013-07-19 2023-10-03 Onyx Therapeutics, Inc. Peptide epoxyketone proteasome inhibitors in combination with pim kinase inhibitors for treatment of cancers
CN103360348B (zh) * 2013-07-25 2015-06-24 苏州鹏旭医药科技有限公司 一种Carfilzomib中间体及其制备方法和制备Carfilzomib的方法
CN105517998A (zh) * 2013-09-06 2016-04-20 桑多斯股份公司 通过曼尼希反应立体选择性合成二醇和三醇以及它们在卡非佐米合成中的用途
US20160215016A1 (en) * 2013-09-06 2016-07-28 Sandoz Ag Synthesis of peptide epoxy ketones
CN104710507B (zh) * 2013-12-11 2018-08-14 深圳翰宇药业股份有限公司 一种卡非佐米的制备方法
WO2015121769A1 (en) 2014-02-13 2015-08-20 Ranbaxy Laboratories Limited Process for the preparation of methyl n-[(benzyloxy)-carbonyl]-l-leucyl-l-phenylalaninate
CN105960399B (zh) 2014-07-14 2018-09-25 宁波圣健生物医药科技有限公司 酶抑制剂环氧酮化合物
US10329325B2 (en) 2014-09-24 2019-06-25 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxo-pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide
WO2016069479A1 (en) 2014-10-27 2016-05-06 Apicore Us Llc Methods of making carfilzomib and intermediates thereof
CN107548400A (zh) 2014-12-02 2018-01-05 费森尤斯卡比肿瘤学有限公司 卡非佐米的纯化方法
WO2016108204A1 (en) 2014-12-31 2016-07-07 Dr. Reddy's Laboratories Limited Co-crystal of carfilzomib with maleic acid and process for the preparation of pure carfilzomib
WO2016116882A2 (en) * 2015-01-23 2016-07-28 Leiutis Pharmaceuticals Pvt Ltd Novel compositions of carfilzomib
WO2016170544A1 (en) * 2015-04-22 2016-10-27 Msn Laboratories Private Limited Process for the preparation of (2s)-n-((s)-1-((s)-4-methyl-1-((r)-2-methyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((s)-2-(2-morpholino acetamido)-4-phenylbutanamido)-4-methylpentanamide
WO2016170489A1 (en) 2015-04-24 2016-10-27 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of proteasome inhibitor
ES2888800T3 (es) 2015-05-21 2022-01-07 Laurus Labs Ltd Procedimiento mejorado para la preparación de carfilzomib o sales farmacéuticamente aceptables del mismo
US11072616B2 (en) 2015-11-11 2021-07-27 Universite De Montreal Cyclic peptides targeting alpha-4-beta-7 integrin
WO2018024645A1 (en) 2016-08-02 2018-02-08 Synthon B.V. Process for making carfilzomib
EP3512835B1 (de) 2016-09-14 2021-06-09 Fresenius Kabi Oncology Limited Verfahren zur reinigung eines carfilzomib-zwischenprodukts
CN110088121A (zh) 2016-11-11 2019-08-02 循环治疗学公司 靶向α4β7整联蛋白的环肽多聚体
EP3330260A1 (de) 2016-12-01 2018-06-06 Enantia, S.L. Verfahren zur herstellung eines zwischenprodukts zur synthese von i. a. carfilzomib
CN106946981B (zh) * 2017-03-08 2020-08-21 南京陵瑞医药科技有限公司 一种四肽环氧丙烷衍生物及其制备方法和用途
AU2018266248B2 (en) 2017-05-10 2022-01-27 Zealand Pharma A/S Homodetic cyclic peptides targeting a4β7 integrin
US11401334B2 (en) 2017-09-14 2022-08-02 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer with anti-BCMA binding protein and proteosome inhibitor
CN113185575B (zh) * 2021-05-11 2022-07-12 四川大学 一种花生抗氧化多肽及其制备方法
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2024097905A1 (en) 2022-11-02 2024-05-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
JPH01136498A (ja) 1987-11-21 1989-05-29 Nec Corp 状態監視用情報伝送装置
US5135919A (en) * 1988-01-19 1992-08-04 Children's Medical Center Corporation Method and a pharmaceutical composition for the inhibition of angiogenesis
US5441944A (en) * 1989-04-23 1995-08-15 The Trustees Of The University Of Pennsylvania Substituted cyclodextrin sulfates and their uses as growth modulating agents
US5071957A (en) * 1989-08-04 1991-12-10 Bristol-Myers Company Antibiotic BU-4061T
US4990448A (en) 1989-08-04 1991-02-05 Bristol-Myers Company Bu-4061T
KR0166088B1 (ko) * 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
JPH05506777A (ja) 1990-03-05 1993-10-07 セファロン、インコーポレーテッド キモトリプシン様プロテアーゼ及びそれらの阻害剤
US5340736A (en) 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
GB9300048D0 (en) 1993-01-04 1993-03-03 Wellcome Found Endothelin converting enzyme inhibitors
US5693617A (en) 1994-03-15 1997-12-02 Proscript, Inc. Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US6335358B1 (en) 1995-04-12 2002-01-01 President And Fellows Of Harvard College Lactacystin analogs
AU4499697A (en) 1996-09-13 1998-04-02 New York University Method for treating parasitic diseases with proteasome inhibitors
EP1136498A1 (de) 1996-10-18 2001-09-26 Vertex Pharmaceuticals Incorporated Inhibitoren von serinproteasen, insbesondere von NS3-protease des hepatitis-c-virus
NZ335276A (en) * 1996-10-18 2000-09-29 Vertex Pharma Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease
WO1998025460A1 (en) 1996-12-13 1998-06-18 Zymogenetics, Inc. Compositions and methods for stimulating bone growth
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
AU750207B2 (en) * 1997-06-13 2002-07-11 Cydex Pharmaceuticals, Inc. Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof
US6099851A (en) * 1998-06-02 2000-08-08 Weisman; Kenneth M. Therapeutic uses of leuprolide acetate
US6462019B1 (en) * 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6838436B1 (en) * 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6902721B1 (en) * 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2000023614A1 (en) * 1998-10-20 2000-04-27 Millennium Pharmaceuticals, Inc. Method for monitoring proteasome inhibitor drug action
US6492333B1 (en) 1999-04-09 2002-12-10 Osteoscreen, Inc. Treatment of myeloma bone disease with proteasomal and NF-κB activity inhibitors
US6831099B1 (en) * 1999-05-12 2004-12-14 Yale University Enzyme inhibition
WO2001028579A2 (en) 1999-10-20 2001-04-26 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone and hair growth
AU2002218133A1 (en) * 2000-10-12 2002-04-22 Viromics Gmbh Agents for the treatment of viral infections
JP4412586B2 (ja) 2002-01-08 2010-02-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 エポネマイシンおよびエポキソマイシン類似物およびそれらの用途
EP1496916A2 (de) * 2002-04-09 2005-01-19 Greenville Hospital System Metastasen-modulierende wirkung von hochsulfierten oligosacchariden
US20030224469A1 (en) * 2002-06-03 2003-12-04 Buchholz Tonia J. Methods and kits for assays utilizing fluorescence polarization
US8198270B2 (en) * 2004-04-15 2012-06-12 Onyx Therapeutics, Inc. Compounds for proteasome enzyme inhibition
PL1745064T3 (pl) * 2004-04-15 2011-06-30 Onyx Therapeutics Inc Związki do hamowania enzymu proteazomu
US7232818B2 (en) 2004-04-15 2007-06-19 Proteolix, Inc. Compounds for enzyme inhibition
AU2005243140A1 (en) 2004-05-10 2005-11-24 Proteolix, Inc. Synthesis of amino acid keto-epoxides
CA2565407A1 (en) 2004-05-10 2005-11-24 Proteolix, Inc. Compounds for enzyme inhibition
US20060088471A1 (en) * 2004-10-20 2006-04-27 Proteolix, Inc. Compounds for enzyme inhibition
PT2260835E (pt) * 2004-12-07 2013-05-28 Onyx Therapeutics Inc Composição para inibição do proteassoma
WO2006099261A2 (en) 2005-03-11 2006-09-21 The University Of North Carolina At Chapel Hill Potent and specific immunoproteasome inhibitors
CN105237621A (zh) * 2005-11-09 2016-01-13 欧尼斯治疗公司 用于酶抑制的化合物
AR057227A1 (es) 2005-12-09 2007-11-21 Centocor Inc Metodo para usar antagonistas de il6 con inhibidores del proteasoma
DE102006026464A1 (de) * 2006-06-01 2007-12-06 Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus
MX2008016512A (es) * 2006-06-19 2009-02-26 Proteolix Inc Epoxicetonas peptidicas para la inhibicion del proteasoma.
JP4325683B2 (ja) * 2007-02-14 2009-09-02 セイコーエプソン株式会社 画像表示装置、及び画像表示装置の制御方法
WO2008140782A2 (en) 2007-05-10 2008-11-20 Proteolix, Inc. Compounds for enzyme inhibition
CL2008002966A1 (es) 2007-10-04 2010-06-25 Onyx Therapeutics Inc Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros.
AP2011005690A0 (en) 2008-10-21 2011-06-30 Onyx Therapeutics Inc Combination therapy with peptide epoxyketones.

Also Published As

Publication number Publication date
BRPI0509879A (pt) 2007-10-16
EP1745064A2 (de) 2007-01-24
AU2005238445B2 (en) 2012-05-03
JP2012041346A (ja) 2012-03-01
US20120094930A1 (en) 2012-04-19
IL178400A (en) 2012-02-29
US20120094928A1 (en) 2012-04-19
CN102174076A (zh) 2011-09-07
US8207297B2 (en) 2012-06-26
US8207127B2 (en) 2012-06-26
US20120277146A1 (en) 2012-11-01
IL178400A0 (en) 2007-02-11
EP1745064B1 (de) 2011-01-05
US8207126B2 (en) 2012-06-26
ATE494298T1 (de) 2011-01-15
AU2005238445A1 (en) 2005-11-10
HK1097860A1 (en) 2007-07-06
SG185306A1 (en) 2012-11-29
US20120094929A1 (en) 2012-04-19
CA2562411A1 (en) 2005-11-10
CN103554222A (zh) 2014-02-05
DE602005025750D1 (de) 2011-02-17
DK1745064T3 (da) 2011-04-11
JP2014012676A (ja) 2014-01-23
PL1745064T3 (pl) 2011-06-30
US20120101050A1 (en) 2012-04-26
US20130324459A1 (en) 2013-12-05
US8207124B2 (en) 2012-06-26
US8207125B2 (en) 2012-06-26
PT1745064E (pt) 2011-03-23
IL217210A0 (en) 2012-01-31
WO2005105827A2 (en) 2005-11-10
JP5616569B2 (ja) 2014-10-29
JP2008501637A (ja) 2008-01-24
IL217211A0 (en) 2012-01-31
CY1117244T1 (el) 2017-04-05
US20080200398A1 (en) 2008-08-21
US20120094926A1 (en) 2012-04-19
US20120101048A1 (en) 2012-04-26
US8324174B2 (en) 2012-12-04
WO2005105827A3 (en) 2006-03-30
US8129346B2 (en) 2012-03-06

Similar Documents

Publication Publication Date Title
SG152239A1 (en) Compounds for proteasome enzyme inhibition
SI2030981T1 (sl) Spojine za inhibiranje proteasomskega encima
CY2016009I2 (el) Ενωσεις για την αναστολη του ενζυμου πρωτεασωματος
IN2014CN03629A (de)
SG145694A1 (en) Novel compounds
HK1220208A1 (zh) 用於酶抑制的化合物
AU2003298826A1 (en) Culture chamber for biologicals
TW200631955A (en) Non-hygroscopic and powdery amorphous pimecrolimus
GB2432609A (en) Method of expansion
EP1543718A4 (de) System zum kultivieren von sämlingen
IL176641A0 (en) Novel culture systems for ex vivo development
SG150511A1 (en) Viral polymerase inhibitors
SG149855A1 (en) N-channel transistor
IL176942A0 (en) Imidazolo-5-yl-2-anilinopyrimidines as agents for the inhibition of cell proliferation
SG149831A1 (en) Benzimidazole derivatives
EP1797064A4 (de) Neue, zur modulation anormaler zellproliferation geeignete verbindungen
SI1745064T1 (sl) Spojine za inhibiranje proteasomskega encima
SG142306A1 (en) Methods for neuroprotection
SG148154A1 (en) Benzannelated compounds as ppar activators
SG144914A1 (en) A method for the preparation of enantiomerically pure mirtazapine
AU2003223661A1 (en) Methods of assaying for cell cycle modulators
EP1731529A4 (de) Den calciumionenausstrom hemmende substanzen
EP1807386A4 (de) Neue, zur modulation anormaler zellproliferation geeignete verbindungen
GB0421359D0 (en) Method for the inactivation of enzymes
SI2260835T1 (sl) Sestavek za inhibiranje proteasoma