SG11202106609WA - Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber - Google Patents

Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber

Info

Publication number
SG11202106609WA
SG11202106609WA SG11202106609WA SG11202106609WA SG11202106609WA SG 11202106609W A SG11202106609W A SG 11202106609WA SG 11202106609W A SG11202106609W A SG 11202106609WA SG 11202106609W A SG11202106609W A SG 11202106609WA SG 11202106609W A SG11202106609W A SG 11202106609WA
Authority
SG
Singapore
Prior art keywords
clarification
filter
cell culture
hollow fiber
mammalian cell
Prior art date
Application number
SG11202106609WA
Inventor
Michael Bransby
Derek Carroll
Philip Yuen
Original Assignee
Repligen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repligen Corp filed Critical Repligen Corp
Publication of SG11202106609WA publication Critical patent/SG11202106609WA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0097—Storing or preservation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B01D69/081—Hollow fibre membranes characterised by the fibre diameter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/261—Polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/262—Polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
    • B01D2239/0428—Rendering the filter material hydrophobic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/12—Special parameters characterising the filtering material
    • B01D2239/1216—Pore size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/12—Special parameters characterising the filtering material
    • B01D2239/1225—Fibre length
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2688—Biological processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/04—Specific sealing means
    • B01D2313/042—Adhesives or glues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/58—Parts of membrane modules specifically adapted for single use
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/28—Degradation or stability over time
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/38—Hydrophobic membranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202106609WA 2018-12-31 2019-12-30 Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber SG11202106609WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862786884P 2018-12-31 2018-12-31
US201962846934P 2019-05-13 2019-05-13
PCT/US2019/068972 WO2020142445A1 (en) 2018-12-31 2019-12-30 Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber

Publications (1)

Publication Number Publication Date
SG11202106609WA true SG11202106609WA (en) 2021-07-29

Family

ID=71122556

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106609WA SG11202106609WA (en) 2018-12-31 2019-12-30 Filter for mammalian cell culture perfusion and clarification with hydrophobic hollow fiber

Country Status (9)

Country Link
US (1) US11680239B2 (en)
EP (1) EP3906107A4 (en)
JP (1) JP2022516516A (en)
KR (1) KR20210096671A (en)
CN (1) CN113226510A (en)
AU (1) AU2019419406B2 (en)
CA (1) CA3122774A1 (en)
SG (1) SG11202106609WA (en)
WO (1) WO2020142445A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230080460A (en) * 2020-10-05 2023-06-07 브리스톨-마이어스 스큅 컴퍼니 How to Concentrate Protein

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3040631A1 (en) * 1980-10-29 1982-05-27 Merck Patent Gmbh, 6100 Darmstadt METHOD FOR SEPARATING METAL CATALYSTS AND USE OF MEMBRANE SEPARATING DEVICES
JPS60232208A (en) 1984-05-04 1985-11-18 Mitsubishi Rayon Co Ltd Treatment of filter module using hollow fiber
JP2000032977A (en) * 1989-02-15 2000-02-02 Hitachi Ltd Cultivation of cell and device therefor
JPH04117600U (en) 1991-03-28 1992-10-21 三菱レイヨン株式会社 Hollow fiber membrane cell culture device
FR2717185B1 (en) * 1994-03-08 1996-07-26 Tech Sep Microfiltration of beer.
EP0672424A1 (en) * 1994-03-16 1995-09-20 Teijin Limited Method of sterilizing a blood dialyzer having semipermeable polymeric membranes by gamma-ray irradiation
JPH10503847A (en) 1994-08-02 1998-04-07 エフエスエム テクノロジーズ リミテッド Filtration membrane device
EP0830364A1 (en) * 1995-06-08 1998-03-25 Progen Industries Limited Method and apparatus for dna extraction
JPH1042851A (en) * 1996-04-12 1998-02-17 Kuraray Co Ltd Production of sake and device therefor
US5914154A (en) * 1997-05-30 1999-06-22 Compact Membrane Systems, Inc. Non-porous gas permeable membrane
WO2001058501A1 (en) 2000-02-09 2001-08-16 Minntech Corporation Apparatus and process for removal of carbon dioxide in a bioreactor system
JP2005110695A (en) 2005-01-06 2005-04-28 Toyobo Co Ltd Device comprising hollow fiber and use thereof
BRPI0919252A2 (en) 2008-09-24 2015-08-11 Medimmune Llc Methods for cell cultivation, virus propagation and purification
EP2177603A1 (en) 2008-09-25 2010-04-21 Gambro Lundia AB Device for renal cell expansion
EP2335814B1 (en) 2008-09-26 2016-12-28 Asahi Kasei Kabushiki Kaisha Use of porous hollow-fiber membrane for producing clarified biomedical culture medium
HUE033279T2 (en) 2011-07-01 2017-11-28 Amgen Inc Mammalian cell culture
JP5935808B2 (en) 2011-09-28 2016-06-15 東レ株式会社 Method for hydrophilizing hollow fiber membrane module
JP2013226486A (en) 2012-04-24 2013-11-07 Toray Ind Inc Sterilization method for separation membrane module, manufacturing method for chemical and membrane separation type continuous fermentation apparatus
JP2014117190A (en) 2012-12-13 2014-06-30 Mitsubishi Rayon Co Ltd Device, module and method for non-adherent cell cultivation
DE102013007927B4 (en) 2013-05-10 2014-12-24 Hoerbiger Automatisierungstechnik Holding Gmbh drive unit
WO2014191296A1 (en) 2013-05-29 2014-12-04 Membrana Gmbh Microporous polyvinylidene fluoride membrane
EP3926051B1 (en) 2014-06-04 2024-05-08 Amgen Inc. Methods for harvesting mammalian cell cultures
KR101969633B1 (en) * 2014-07-10 2019-04-16 아사히 가세이 가부시키가이샤 Membrane distillation apparatus and hydrophobic porous membrane
EP3708835A1 (en) 2015-11-10 2020-09-16 Repligen Corporation Disposable alternating tangential flow filtration units
JP6323702B2 (en) * 2015-12-15 2018-05-16 東洋紡株式会社 Hollow fiber membrane and hollow fiber module for cell culture
EP3442689A1 (en) * 2016-04-11 2019-02-20 Spectrum, Inc. Thick wall hollow fiber tangential flow filter
JP7043125B2 (en) * 2016-10-28 2022-03-29 旭化成メディカル株式会社 Method for recovering useful substances in continuous culture
TWM557639U (en) 2017-04-10 2018-04-01 光譜實驗室公司 Thick wall hollow fiber tangential flow filter

Also Published As

Publication number Publication date
EP3906107A1 (en) 2021-11-10
KR20210096671A (en) 2021-08-05
EP3906107A4 (en) 2023-02-22
CA3122774A1 (en) 2020-07-09
JP2022516516A (en) 2022-02-28
AU2019419406A1 (en) 2021-08-19
WO2020142445A1 (en) 2020-07-09
US11680239B2 (en) 2023-06-20
AU2019419406B2 (en) 2023-05-18
US20200208092A1 (en) 2020-07-02
CN113226510A (en) 2021-08-06

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