SG11202105609RA - Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment - Google Patents
Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environmentInfo
- Publication number
- SG11202105609RA SG11202105609RA SG11202105609RA SG11202105609RA SG11202105609RA SG 11202105609R A SG11202105609R A SG 11202105609RA SG 11202105609R A SG11202105609R A SG 11202105609RA SG 11202105609R A SG11202105609R A SG 11202105609RA SG 11202105609R A SG11202105609R A SG 11202105609RA
- Authority
- SG
- Singapore
- Prior art keywords
- resistance
- immune cells
- genome editing
- enhance functionality
- multiplex genome
- Prior art date
Links
- 238000010362 genome editing Methods 0.000 title 1
- 210000002865 immune cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862772406P | 2018-11-28 | 2018-11-28 | |
PCT/US2019/063641 WO2020113029A2 (fr) | 2018-11-28 | 2019-11-27 | Édition de génome multiplex de cellules immunitaires pour améliorer la fonctionnalité et la résistance à un environnement de suppression |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202105609RA true SG11202105609RA (en) | 2021-06-29 |
Family
ID=69005890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202105609RA SG11202105609RA (en) | 2018-11-28 | 2019-11-27 | Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220031749A1 (fr) |
EP (1) | EP3887518A2 (fr) |
JP (1) | JP2022513652A (fr) |
KR (1) | KR20210096638A (fr) |
CN (1) | CN113272427A (fr) |
AU (1) | AU2019386140A1 (fr) |
BR (1) | BR112021010297A2 (fr) |
CA (1) | CA3121027A1 (fr) |
EA (1) | EA202191463A1 (fr) |
IL (1) | IL283428A (fr) |
MX (1) | MX2021006208A (fr) |
SG (1) | SG11202105609RA (fr) |
WO (1) | WO2020113029A2 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20220016475A (ko) * | 2019-05-01 | 2022-02-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 tgfbr2 유전자 좌에서 재조합 수용체를 발현하는 세포, 관련 폴리뉴클레오티드 및 방법 |
AU2020288829A1 (en) * | 2019-06-04 | 2021-12-02 | Nkarta, Inc. | Combinations of engineered natural killer cells and engineered T cells for immunotherapy |
CA3157344A1 (fr) * | 2019-11-20 | 2021-05-27 | Cartherics Pty. Ltd. | Procede de fourniture de cellules immunitaires a fonction amelioree |
AU2021369476A1 (en) * | 2020-10-26 | 2023-06-08 | Shoreline Biosciences, Inc. | Methods of inducing antibody-dependent cellular cytotoxicity (adcc) using modified natural killer (nk) cells |
US20240010980A1 (en) * | 2020-10-27 | 2024-01-11 | The Regents Of The University Of California | Natural killer cells with enhanced activity |
US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
EP4271798A1 (fr) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions et procédés de différenciation de cellules souches en cellules nk |
CN116783286A (zh) * | 2021-01-20 | 2023-09-19 | 阿维塔斯有限公司 | Rnps向免疫细胞的顺序传递 |
EP4039808A1 (fr) * | 2021-02-08 | 2022-08-10 | Ospedale San Raffaele S.r.l. | Arn guides et leurs utilisations |
WO2022242701A1 (fr) * | 2021-05-20 | 2022-11-24 | Wuxi Biologics (Shanghai) Co., Ltd. | Lymphocytes t gamma-delta génétiquement modifiés et leurs utilisations |
US20240285685A1 (en) * | 2021-05-20 | 2024-08-29 | WuXi Biologics Ireland Limited | Genetically modified nk cells and uses thereof |
WO2023064928A2 (fr) | 2021-10-14 | 2023-04-20 | Arsenal Biosciences, Inc. | Cellules immunitaires ayant des arnsh co-exprimés et des systèmes de porte logique |
WO2023064973A1 (fr) * | 2021-10-19 | 2023-04-27 | Peter Maccallum Cancer Institute | Compositions et méthodes d'immunothérapie |
WO2023081900A1 (fr) * | 2021-11-08 | 2023-05-11 | Juno Therapeutics, Inc. | Lymphocytes t modifiés exprimant un récepteur recombiné de lymphocytes t (tcr) et systèmes et procédés apparentés |
WO2023092020A2 (fr) * | 2021-11-17 | 2023-05-25 | The Regents Of The University Of California | Cibles géniques pour une immunothérapie à base de lymphocytes t pour surmonter des facteurs suppresseurs |
WO2023215278A1 (fr) * | 2022-05-03 | 2023-11-09 | The Broad Institute, Inc. | Cellules immunitaires modifiées et leurs procédés d'utilisation |
WO2024076750A2 (fr) * | 2022-10-07 | 2024-04-11 | Whitehead Institute For Biomedical Research | Macrophages modifiés destinés à être utilisés dans le traitement du cancer |
EP4353741A1 (fr) * | 2022-10-14 | 2024-04-17 | ONK Therapeutics Limited | Cellules tueuses naturelles à double inactivation |
WO2024100203A1 (fr) * | 2022-11-10 | 2024-05-16 | Onk Therapeutics Limited | Polythérapies utilisant des médicaments immunomodulateurs |
CN116590237B (zh) * | 2023-05-29 | 2023-10-31 | 上海贝斯昂科生物科技有限公司 | 一种遗传修饰的自然杀伤细胞及其制备和用途 |
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-
2019
- 2019-11-27 EP EP19827952.3A patent/EP3887518A2/fr active Pending
- 2019-11-27 WO PCT/US2019/063641 patent/WO2020113029A2/fr active Application Filing
- 2019-11-27 MX MX2021006208A patent/MX2021006208A/es unknown
- 2019-11-27 KR KR1020217019926A patent/KR20210096638A/ko unknown
- 2019-11-27 CN CN201980088334.XA patent/CN113272427A/zh active Pending
- 2019-11-27 CA CA3121027A patent/CA3121027A1/fr active Pending
- 2019-11-27 EA EA202191463A patent/EA202191463A1/ru unknown
- 2019-11-27 JP JP2021530101A patent/JP2022513652A/ja active Pending
- 2019-11-27 BR BR112021010297-3A patent/BR112021010297A2/pt unknown
- 2019-11-27 US US17/309,408 patent/US20220031749A1/en active Pending
- 2019-11-27 AU AU2019386140A patent/AU2019386140A1/en active Pending
- 2019-11-27 SG SG11202105609RA patent/SG11202105609RA/en unknown
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Publication number | Publication date |
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EA202191463A1 (ru) | 2021-10-13 |
CN113272427A (zh) | 2021-08-17 |
US20220031749A1 (en) | 2022-02-03 |
WO2020113029A3 (fr) | 2020-07-09 |
KR20210096638A (ko) | 2021-08-05 |
BR112021010297A2 (pt) | 2021-08-24 |
WO2020113029A2 (fr) | 2020-06-04 |
IL283428A (en) | 2021-07-29 |
JP2022513652A (ja) | 2022-02-09 |
AU2019386140A1 (en) | 2021-06-24 |
MX2021006208A (es) | 2021-10-01 |
CA3121027A1 (fr) | 2020-06-04 |
EP3887518A2 (fr) | 2021-10-06 |
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