SG11202005639UA - Preparation of racemic nicotine by reaction of ethyl nicotinate with n-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps - Google Patents

Preparation of racemic nicotine by reaction of ethyl nicotinate with n-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps

Info

Publication number
SG11202005639UA
SG11202005639UA SG11202005639UA SG11202005639UA SG11202005639UA SG 11202005639U A SG11202005639U A SG 11202005639UA SG 11202005639U A SG11202005639U A SG 11202005639UA SG 11202005639U A SG11202005639U A SG 11202005639UA SG 11202005639U A SG11202005639U A SG 11202005639UA
Authority
SG
Singapore
Prior art keywords
vinylpyrrolidone
subsequent
reaction
ethyl nicotinate
racemic nicotine
Prior art date
Application number
SG11202005639UA
Inventor
Beat Weber
Christian Lothschütz
Ben Pan
Original Assignee
Siegfried Ag
Contraf Nicotex Tobacco Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP17210187 priority Critical
Application filed by Siegfried Ag, Contraf Nicotex Tobacco Gmbh filed Critical Siegfried Ag
Priority to PCT/EP2018/085437 priority patent/WO2019121644A1/en
Publication of SG11202005639UA publication Critical patent/SG11202005639UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
SG11202005639UA 2017-12-22 2018-12-18 Preparation of racemic nicotine by reaction of ethyl nicotinate with n-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps SG11202005639UA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP17210187 2017-12-22
PCT/EP2018/085437 WO2019121644A1 (en) 2017-12-22 2018-12-18 Preparation of racemic nicotine by reaction of ethyl nicotinate with n-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps

Publications (1)

Publication Number Publication Date
SG11202005639UA true SG11202005639UA (en) 2020-07-29

Family

ID=60782090

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005639UA SG11202005639UA (en) 2017-12-22 2018-12-18 Preparation of racemic nicotine by reaction of ethyl nicotinate with n-vinylpyrrolidone in the presence of an alcoholate base and subsequent process steps

Country Status (9)

Country Link
US (1) US20200331884A1 (en)
EP (1) EP3728215A1 (en)
KR (1) KR20200103033A (en)
CN (1) CN111511726A (en)
AU (1) AU2018391652A1 (en)
CA (1) CA3085245A1 (en)
IL (1) IL275584D0 (en)
SG (1) SG11202005639UA (en)
WO (1) WO2019121644A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8378111B2 (en) 2011-02-02 2013-02-19 Divi's Laboratories, Ltd. Process for the resolution of (R,S)-nicotine
US8367837B2 (en) 2011-02-14 2013-02-05 Divi's Laboratories, Ltd. Process for the preparation of (R,S)-nicotine
EP3209653A4 (en) 2014-10-22 2018-06-06 Next Generation Labs, LLC Process for the preparation of (r,s)-nicotine
US9809567B2 (en) 2014-12-09 2017-11-07 Njoy, Llc Synthesis and resolution of nicotine
CA3048820A1 (en) 2015-12-30 2017-07-06 Next Generation Labs, LLC Nicotine replacement therapy products comprising synthetic nicotine

Also Published As

Publication number Publication date
AU2018391652A1 (en) 2020-07-02
WO2019121644A1 (en) 2019-06-27
CN111511726A (en) 2020-08-07
US20200331884A1 (en) 2020-10-22
KR20200103033A (en) 2020-09-01
CA3085245A1 (en) 2019-06-27
IL275584D0 (en) 2020-08-31
EP3728215A1 (en) 2020-10-28

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