SG11202005422TA - Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump - Google Patents

Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump

Info

Publication number
SG11202005422TA
SG11202005422TA SG11202005422TA SG11202005422TA SG11202005422TA SG 11202005422T A SG11202005422T A SG 11202005422TA SG 11202005422T A SG11202005422T A SG 11202005422TA SG 11202005422T A SG11202005422T A SG 11202005422TA SG 11202005422T A SG11202005422T A SG 11202005422TA
Authority
SG
Singapore
Prior art keywords
calibration
blood flow
estimating
intravascular
blood pump
Prior art date
Application number
SG11202005422TA
Inventor
Thorsten Siess
Christoph Nix
Stefan Bönsch
Original Assignee
Abiomed Europe Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiomed Europe Gmbh filed Critical Abiomed Europe Gmbh
Publication of SG11202005422TA publication Critical patent/SG11202005422TA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50Details relating to control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/135Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
    • A61M60/139Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting inside the aorta, e.g. intra-aortic balloon pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow
    • A61B5/0265Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
    • A61B5/027Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter using catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/13Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/135Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/122Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/17Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps
    • A61M60/174Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart inside a ventricle, e.g. intraventricular balloon pumps discharging the blood to the ventricle or arterial system via a cannula internal to the ventricle or arterial system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20Type thereof
    • A61M60/205Non-positive displacement blood pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20Type thereof
    • A61M60/205Non-positive displacement blood pumps
    • A61M60/216Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/403Details relating to driving for non-positive displacement blood pumps
    • A61M60/408Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A61M60/414Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50Details relating to control
    • A61M60/508Electronic control means, e.g. for feedback regulation
    • A61M60/538Regulation using real-time blood pump operational parameter data, e.g. motor current
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50Details relating to control
    • A61M60/508Electronic control means, e.g. for feedback regulation
    • A61M60/538Regulation using real-time blood pump operational parameter data, e.g. motor current
    • A61M60/546Regulation using real-time blood pump operational parameter data, e.g. motor current of blood flow, e.g. by adapting rotor speed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80Constructional details other than related to driving
    • A61M60/855Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/857Implantable blood tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80Constructional details other than related to driving
    • A61M60/855Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/865Devices for guiding or inserting pumps or pumping devices into the patient's body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/10General characteristics of the apparatus with powered movement mechanisms
    • A61M2205/103General characteristics of the apparatus with powered movement mechanisms rotating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • A61M2205/3334Measuring or controlling the flow rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3365Rotational speed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3368Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/70General characteristics of the apparatus with testing or calibration facilities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/70General characteristics of the apparatus with testing or calibration facilities
    • A61M2205/702General characteristics of the apparatus with testing or calibration facilities automatically during use

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • External Artificial Organs (AREA)
SG11202005422TA 2018-01-09 2019-01-08 Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump SG11202005422TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18150702.1A EP3508230A1 (en) 2018-01-09 2018-01-09 Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump
PCT/EP2019/050339 WO2019137911A1 (en) 2018-01-09 2019-01-08 Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump

Publications (1)

Publication Number Publication Date
SG11202005422TA true SG11202005422TA (en) 2020-07-29

Family

ID=61074282

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005422TA SG11202005422TA (en) 2018-01-09 2019-01-08 Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump

Country Status (12)

Country Link
US (1) US20200360582A1 (en)
EP (3) EP3508230A1 (en)
JP (2) JP7314150B2 (en)
KR (1) KR20200108317A (en)
CN (3) CN117282016A (en)
AU (1) AU2019207663A1 (en)
CA (1) CA3096964A1 (en)
DK (1) DK3737436T3 (en)
ES (1) ES2909614T3 (en)
IL (2) IL275161B1 (en)
SG (1) SG11202005422TA (en)
WO (1) WO2019137911A1 (en)

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WO2013183060A2 (en) 2012-06-06 2013-12-12 Magenta Medical Ltd. Prosthetic renal valve
US10583231B2 (en) 2013-03-13 2020-03-10 Magenta Medical Ltd. Blood pump
US10039874B2 (en) 2013-03-13 2018-08-07 Magenta Medical Ltd. Renal pump
US11291824B2 (en) 2015-05-18 2022-04-05 Magenta Medical Ltd. Blood pump
CN115040776A (en) 2016-10-25 2022-09-13 马真塔医药有限公司 Ventricular assist device
CN110049792B (en) 2016-11-23 2022-01-18 马真塔医药有限公司 Blood pump
US10905808B2 (en) 2018-01-10 2021-02-02 Magenta Medical Ltd. Drive cable for use with a blood pump
DE102018201030A1 (en) 2018-01-24 2019-07-25 Kardion Gmbh Magnetic coupling element with magnetic bearing function
DE102018207611A1 (en) 2018-05-16 2019-11-21 Kardion Gmbh Rotor bearing system
DE102018208541A1 (en) 2018-05-30 2019-12-05 Kardion Gmbh Axial pump for a cardiac assist system and method of making an axial pump for a cardiac assist system
DE102018211327A1 (en) 2018-07-10 2020-01-16 Kardion Gmbh Impeller for an implantable vascular support system
EP3782666B1 (en) 2019-01-24 2021-08-11 Magenta Medical Ltd. Manufacturing an impeller
DE102020102474A1 (en) 2020-01-31 2021-08-05 Kardion Gmbh Pump for conveying a fluid and method for manufacturing a pump
CN116020052A (en) * 2021-10-25 2023-04-28 丰凯医疗器械(上海)有限公司 Method and device for determining pump blood flow of blood pump, electronic device and storage medium
CN116726378B (en) * 2023-06-13 2024-03-22 心擎医疗(苏州)股份有限公司 Flow determination method, training method, device and medium of flow detection model
CN117282017B (en) * 2023-10-07 2024-06-14 心擎医疗(苏州)股份有限公司 Interventional pump flow estimation method, device, equipment and ventricular assist device

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JP3546092B2 (en) * 1995-04-03 2004-07-21 Ntn株式会社 Magnetic levitation pump
DE10060275A1 (en) 2000-12-05 2002-06-13 Impella Cardiotech Ag Method for calibrating a pressure sensor or a flow sensor on a rotary pump
JP4440499B2 (en) * 2001-08-29 2010-03-24 泉工医科工業株式会社 Centrifugal pump drive
JP4004440B2 (en) * 2003-07-28 2007-11-07 テルモ株式会社 Liquid pump device
JP4521547B2 (en) * 2004-04-15 2010-08-11 株式会社サンメディカル技術研究所 Blood pump flow estimation device
RU2009140665A (en) * 2007-04-05 2011-05-10 Микромед Текнолоджи, Инк. (Us) BLOOD PUMPING SYSTEM AND METHOD OF ITS OPERATION
US8834404B2 (en) * 2009-03-30 2014-09-16 Steve Andre Beaudin Apparatus, system and methods for extracorporeal blood processing for selectively cooling the brain relative to the body during hyperthermic treatment or to induce hypothermia of the brain
JP5427620B2 (en) * 2010-01-15 2014-02-26 株式会社サンメディカル技術研究所 Blood pump flow estimation method
US9713663B2 (en) * 2013-04-30 2017-07-25 Tc1 Llc Cardiac pump with speed adapted for ventricle unloading
US10029040B2 (en) * 2014-08-08 2018-07-24 Heartware, Inc. Implantable pump with tapered diffuser region
EP3205359B1 (en) * 2016-02-11 2018-08-29 Abiomed Europe GmbH Blood pump system
EP3263148B1 (en) * 2016-06-29 2019-05-08 Berlin Heart GmbH Method for determining the operating parameters of a blood pump
US10376162B2 (en) * 2016-09-19 2019-08-13 Abiomed, Inc. Cardiovascular assist system that quantifies heart function and facilitates heart recovery

Also Published As

Publication number Publication date
AU2019207663A1 (en) 2020-06-25
WO2019137911A1 (en) 2019-07-18
EP3508230A1 (en) 2019-07-10
DK3737436T3 (en) 2022-03-28
KR20200108317A (en) 2020-09-17
EP4059559A1 (en) 2022-09-21
CA3096964A1 (en) 2019-07-18
EP3737436A1 (en) 2020-11-18
ES2909614T3 (en) 2022-05-09
EP3737436B1 (en) 2022-03-09
IL275161B1 (en) 2024-07-01
CN117282015A (en) 2023-12-26
IL313737A (en) 2024-08-01
JP2021511106A (en) 2021-05-06
US20200360582A1 (en) 2020-11-19
IL275161A (en) 2020-07-30
CN111565771A (en) 2020-08-21
CN117282016A (en) 2023-12-26
JP2023126385A (en) 2023-09-07
JP7314150B2 (en) 2023-07-25
CN111565771B (en) 2023-10-27

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