SG11202004733WA - Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production - Google Patents

Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production

Info

Publication number
SG11202004733WA
SG11202004733WA SG11202004733WA SG11202004733WA SG11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA
Authority
SG
Singapore
Prior art keywords
pyrimidinylamino
polymorphs
production
methods
solid forms
Prior art date
Application number
SG11202004733WA
Inventor
Travis Remarchuk
Anantha Sudhakar
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of SG11202004733WA publication Critical patent/SG11202004733WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
SG11202004733WA 2017-11-21 2018-11-20 Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production SG11202004733WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762589276P 2017-11-21 2017-11-21
PCT/US2018/062102 WO2019104086A1 (en) 2017-11-21 2018-11-20 Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production

Publications (1)

Publication Number Publication Date
SG11202004733WA true SG11202004733WA (en) 2020-06-29

Family

ID=66631734

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202004733WA SG11202004733WA (en) 2017-11-21 2018-11-20 Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production

Country Status (22)

Country Link
US (3) US10370361B2 (en)
EP (1) EP3717473B1 (en)
JP (1) JP7303821B2 (en)
KR (1) KR20200089713A (en)
CN (1) CN111819174A (en)
AR (1) AR113893A1 (en)
AU (1) AU2018372180B2 (en)
BR (1) BR112020010215A2 (en)
CA (1) CA3083022A1 (en)
CL (1) CL2020001346A1 (en)
CO (1) CO2020006206A2 (en)
CR (1) CR20200216A (en)
EA (1) EA202091279A1 (en)
IL (1) IL274824A (en)
JO (1) JOP20200128A1 (en)
MA (1) MA51222A (en)
MX (1) MX2020005332A (en)
PE (1) PE20210157A1 (en)
SG (1) SG11202004733WA (en)
TW (1) TWI823878B (en)
UA (1) UA126414C2 (en)
WO (1) WO2019104086A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202091279A1 (en) * 2017-11-21 2020-08-19 Денали Терапьютикс Инк. POLYMORPHES AND SOLID FORMS OF PYRIMIDINYLAMINO-PYRAZOL COMPOUNDS AND METHODS OF THEIR PREPARATION
WO2019126383A1 (en) 2017-12-20 2019-06-27 Denali Therapeutics Inc. Process for the preparation of pyrimidinyl-4-aminopyrazole compounds
WO2023174946A1 (en) 2022-03-15 2023-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Early and non-invasive method for assessing a subject's risk of having parkinson's disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2574168B9 (en) * 2010-05-21 2016-10-05 Incyte Holdings Corporation Topical formulation for a jak inhibitor
MA34299B1 (en) 2010-06-04 2013-06-01 Hoffmann La Roche AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF LRRK2
GB201015949D0 (en) 2010-09-22 2010-11-03 Medical Res Council Technology Compounds
NO2638031T3 (en) 2010-11-10 2018-03-10
EP3121174A1 (en) 2011-11-29 2017-01-25 F. Hoffmann-La Roche AG 2-(phenyl or pyrid-3-yl) aminopyrimidine derivatives as kinase lrrk2 modulators for the treatment of parkinson's disease
MX349556B (en) 2011-11-29 2017-08-03 Genentech Inc Aminopyrimidine derivatives as lrrk2 modulators.
AR089182A1 (en) 2011-11-29 2014-08-06 Hoffmann La Roche AMINOPIRIMIDINE DERIVATIVES AS MODULATORS OF LRRK2
EP3121173A1 (en) 2011-11-29 2017-01-25 F. Hoffmann-La Roche AG Aminopyrimidine derivatives as lrrk2 modulators
WO2013164323A1 (en) 2012-05-03 2013-11-07 F. Hoffmann-La Roche Ag Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease
CA2870049C (en) 2012-05-03 2020-12-29 Charles Baker-Glenn Pyrazole aminopyrimidine derivatives as lrrk2 modulators
KR102553188B1 (en) 2016-06-16 2023-07-11 데날리 테라퓨틱스 인크. Pyrimidin-2-ylamino-1H-pyrazole as an LRRK2 inhibitor for use in the treatment of neurodegenerative disorders
EA202091279A1 (en) * 2017-11-21 2020-08-19 Денали Терапьютикс Инк. POLYMORPHES AND SOLID FORMS OF PYRIMIDINYLAMINO-PYRAZOL COMPOUNDS AND METHODS OF THEIR PREPARATION

Also Published As

Publication number Publication date
CO2020006206A2 (en) 2020-08-10
US11427571B2 (en) 2022-08-30
US20210087176A1 (en) 2021-03-25
AU2018372180B2 (en) 2023-08-17
PE20210157A1 (en) 2021-01-26
MX2020005332A (en) 2021-01-08
WO2019104086A1 (en) 2019-05-31
JP2021504450A (en) 2021-02-15
MA51222A (en) 2020-10-07
IL274824A (en) 2020-07-30
EP3717473A1 (en) 2020-10-07
US10370361B2 (en) 2019-08-06
KR20200089713A (en) 2020-07-27
JP7303821B2 (en) 2023-07-05
JOP20200128A1 (en) 2020-05-21
CL2020001346A1 (en) 2020-11-20
UA126414C2 (en) 2022-09-28
EP3717473A4 (en) 2021-07-07
AR113893A1 (en) 2020-06-24
EA202091279A1 (en) 2020-08-19
CN111819174A (en) 2020-10-23
CR20200216A (en) 2021-03-19
BR112020010215A2 (en) 2020-11-03
TW201925190A (en) 2019-07-01
TWI823878B (en) 2023-12-01
US20190194170A1 (en) 2019-06-27
EP3717473B1 (en) 2024-01-10
US10851088B2 (en) 2020-12-01
AU2018372180A1 (en) 2020-06-18
US20190315723A1 (en) 2019-10-17
CA3083022A1 (en) 2019-05-31

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