SG11202004733WA - Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production - Google Patents
Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of productionInfo
- Publication number
- SG11202004733WA SG11202004733WA SG11202004733WA SG11202004733WA SG11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA SG 11202004733W A SG11202004733W A SG 11202004733WA
- Authority
- SG
- Singapore
- Prior art keywords
- pyrimidinylamino
- polymorphs
- production
- methods
- solid forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762589276P | 2017-11-21 | 2017-11-21 | |
PCT/US2018/062102 WO2019104086A1 (en) | 2017-11-21 | 2018-11-20 | Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202004733WA true SG11202004733WA (en) | 2020-06-29 |
Family
ID=66631734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202004733WA SG11202004733WA (en) | 2017-11-21 | 2018-11-20 | Polymorphs and solid forms of a pyrimidinylamino-pyrazole compound, and methods of production |
Country Status (22)
Country | Link |
---|---|
US (3) | US10370361B2 (en) |
EP (1) | EP3717473B1 (en) |
JP (1) | JP7303821B2 (en) |
KR (1) | KR20200089713A (en) |
CN (1) | CN111819174A (en) |
AR (1) | AR113893A1 (en) |
AU (1) | AU2018372180B2 (en) |
BR (1) | BR112020010215A2 (en) |
CA (1) | CA3083022A1 (en) |
CL (1) | CL2020001346A1 (en) |
CO (1) | CO2020006206A2 (en) |
CR (1) | CR20200216A (en) |
EA (1) | EA202091279A1 (en) |
IL (1) | IL274824A (en) |
JO (1) | JOP20200128A1 (en) |
MA (1) | MA51222A (en) |
MX (1) | MX2020005332A (en) |
PE (1) | PE20210157A1 (en) |
SG (1) | SG11202004733WA (en) |
TW (1) | TWI823878B (en) |
UA (1) | UA126414C2 (en) |
WO (1) | WO2019104086A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA202091279A1 (en) * | 2017-11-21 | 2020-08-19 | Денали Терапьютикс Инк. | POLYMORPHES AND SOLID FORMS OF PYRIMIDINYLAMINO-PYRAZOL COMPOUNDS AND METHODS OF THEIR PREPARATION |
WO2019126383A1 (en) | 2017-12-20 | 2019-06-27 | Denali Therapeutics Inc. | Process for the preparation of pyrimidinyl-4-aminopyrazole compounds |
WO2023174946A1 (en) | 2022-03-15 | 2023-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Early and non-invasive method for assessing a subject's risk of having parkinson's disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2574168B9 (en) * | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
MA34299B1 (en) | 2010-06-04 | 2013-06-01 | Hoffmann La Roche | AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF LRRK2 |
GB201015949D0 (en) | 2010-09-22 | 2010-11-03 | Medical Res Council Technology | Compounds |
NO2638031T3 (en) | 2010-11-10 | 2018-03-10 | ||
EP3121174A1 (en) | 2011-11-29 | 2017-01-25 | F. Hoffmann-La Roche AG | 2-(phenyl or pyrid-3-yl) aminopyrimidine derivatives as kinase lrrk2 modulators for the treatment of parkinson's disease |
MX349556B (en) | 2011-11-29 | 2017-08-03 | Genentech Inc | Aminopyrimidine derivatives as lrrk2 modulators. |
AR089182A1 (en) | 2011-11-29 | 2014-08-06 | Hoffmann La Roche | AMINOPIRIMIDINE DERIVATIVES AS MODULATORS OF LRRK2 |
EP3121173A1 (en) | 2011-11-29 | 2017-01-25 | F. Hoffmann-La Roche AG | Aminopyrimidine derivatives as lrrk2 modulators |
WO2013164323A1 (en) | 2012-05-03 | 2013-11-07 | F. Hoffmann-La Roche Ag | Pyrazole aminopyrimidine derivatives as lrrk2 modulators for use in the treatment of parkinson's disease |
CA2870049C (en) | 2012-05-03 | 2020-12-29 | Charles Baker-Glenn | Pyrazole aminopyrimidine derivatives as lrrk2 modulators |
KR102553188B1 (en) | 2016-06-16 | 2023-07-11 | 데날리 테라퓨틱스 인크. | Pyrimidin-2-ylamino-1H-pyrazole as an LRRK2 inhibitor for use in the treatment of neurodegenerative disorders |
EA202091279A1 (en) * | 2017-11-21 | 2020-08-19 | Денали Терапьютикс Инк. | POLYMORPHES AND SOLID FORMS OF PYRIMIDINYLAMINO-PYRAZOL COMPOUNDS AND METHODS OF THEIR PREPARATION |
-
2018
- 2018-11-20 EA EA202091279A patent/EA202091279A1/en unknown
- 2018-11-20 WO PCT/US2018/062102 patent/WO2019104086A1/en active Application Filing
- 2018-11-20 CN CN201880081321.5A patent/CN111819174A/en active Pending
- 2018-11-20 CA CA3083022A patent/CA3083022A1/en active Pending
- 2018-11-20 JP JP2020545076A patent/JP7303821B2/en active Active
- 2018-11-20 MX MX2020005332A patent/MX2020005332A/en unknown
- 2018-11-20 US US16/197,037 patent/US10370361B2/en active Active
- 2018-11-20 SG SG11202004733WA patent/SG11202004733WA/en unknown
- 2018-11-20 UA UAA202003681A patent/UA126414C2/en unknown
- 2018-11-20 EP EP18881859.5A patent/EP3717473B1/en active Active
- 2018-11-20 PE PE2020000558A patent/PE20210157A1/en unknown
- 2018-11-20 CR CR20200216A patent/CR20200216A/en unknown
- 2018-11-20 BR BR112020010215-6A patent/BR112020010215A2/en unknown
- 2018-11-20 AR ARP180103389A patent/AR113893A1/en unknown
- 2018-11-20 JO JOP/2020/0128A patent/JOP20200128A1/en unknown
- 2018-11-20 MA MA051222A patent/MA51222A/en unknown
- 2018-11-20 TW TW107141257A patent/TWI823878B/en active
- 2018-11-20 KR KR1020207017598A patent/KR20200089713A/en not_active Application Discontinuation
- 2018-11-20 AU AU2018372180A patent/AU2018372180B2/en active Active
-
2019
- 2019-06-20 US US16/447,713 patent/US10851088B2/en active Active
-
2020
- 2020-05-20 IL IL274824A patent/IL274824A/en unknown
- 2020-05-21 CO CONC2020/0006206A patent/CO2020006206A2/en unknown
- 2020-05-21 CL CL2020001346A patent/CL2020001346A1/en unknown
- 2020-11-27 US US17/105,870 patent/US11427571B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CO2020006206A2 (en) | 2020-08-10 |
US11427571B2 (en) | 2022-08-30 |
US20210087176A1 (en) | 2021-03-25 |
AU2018372180B2 (en) | 2023-08-17 |
PE20210157A1 (en) | 2021-01-26 |
MX2020005332A (en) | 2021-01-08 |
WO2019104086A1 (en) | 2019-05-31 |
JP2021504450A (en) | 2021-02-15 |
MA51222A (en) | 2020-10-07 |
IL274824A (en) | 2020-07-30 |
EP3717473A1 (en) | 2020-10-07 |
US10370361B2 (en) | 2019-08-06 |
KR20200089713A (en) | 2020-07-27 |
JP7303821B2 (en) | 2023-07-05 |
JOP20200128A1 (en) | 2020-05-21 |
CL2020001346A1 (en) | 2020-11-20 |
UA126414C2 (en) | 2022-09-28 |
EP3717473A4 (en) | 2021-07-07 |
AR113893A1 (en) | 2020-06-24 |
EA202091279A1 (en) | 2020-08-19 |
CN111819174A (en) | 2020-10-23 |
CR20200216A (en) | 2021-03-19 |
BR112020010215A2 (en) | 2020-11-03 |
TW201925190A (en) | 2019-07-01 |
TWI823878B (en) | 2023-12-01 |
US20190194170A1 (en) | 2019-06-27 |
EP3717473B1 (en) | 2024-01-10 |
US10851088B2 (en) | 2020-12-01 |
AU2018372180A1 (en) | 2020-06-18 |
US20190315723A1 (en) | 2019-10-17 |
CA3083022A1 (en) | 2019-05-31 |
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