SG11201807773QA - Malassezin and analogs thereof as skin brightening agents - Google Patents
Malassezin and analogs thereof as skin brightening agentsInfo
- Publication number
- SG11201807773QA SG11201807773QA SG11201807773QA SG11201807773QA SG11201807773QA SG 11201807773Q A SG11201807773Q A SG 11201807773QA SG 11201807773Q A SG11201807773Q A SG 11201807773QA SG 11201807773Q A SG11201807773Q A SG 11201807773QA SG 11201807773Q A SG11201807773Q A SG 11201807773QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- compounds
- pct
- analogs
- methods
- Prior art date
Links
- 238000005282 brightening Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 210000003491 skin Anatomy 0.000 abstract 3
- 102000003984 Aryl Hydrocarbon Receptors Human genes 0.000 abstract 2
- 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 abstract 2
- 210000002752 melanocyte Anatomy 0.000 abstract 2
- 210000002780 melanosome Anatomy 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000021710 Hyperpigmentation disease Diseases 0.000 abstract 1
- 241000555676 Malassezia Species 0.000 abstract 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000008436 biogenesis Effects 0.000 abstract 1
- 208000000069 hyperpigmentation Diseases 0.000 abstract 1
- 230000003810 hyperpigmentation Effects 0.000 abstract 1
- 230000008099 melanin synthesis Effects 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011111011001111101011111111101111011111 International Bureau .. .... ..Yejd ..... .....1 (10) International Publication Number (43) International Publication Date WO 2017/156424 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07D 487/04 (2006.01) A61K 8/49 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, C07D 209/12 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2017/021843 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 10 March 2017 (10.03.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/306,468 10 March 2016 (10.03.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors; and TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicants : EINZIGER, Michael [US/US]; 2850 Ocean DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Park Boulevard, #300, Santa Monica, CA 90405 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SIMPSON, Ann Marie [US/US]; 2850 Ocean Park SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Boulevard, #300, Santa Monica, CA 90405 (US). GW, KM, ML, MR, NE, SN, TD, TG). (74) Agents: LYNCH, Christopher D. et al.; Proskauer Rose Published: LLP, 2049 Century Park East Los Angeles, CA 90067 — with international search report (Art. 21(3)) (US) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, 1-1 7r N 71' ilr) 1-1 (54) Title: MALASSEZIN AND ANALOGS THEREOF AS SKIN BRIGHTENING AGENTS I r ----- (57) : The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, corn- 1-1 positions, and methods of the present invention generally involve compounds produced by a Malassezia yeast, and chemical analogs ei thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be 0 used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an arylhydrocarbon receptor (AhR), improve hyperpig - mentation caused by a hyperpigmentation disorder, and modulate melanin production, melanosome biogenesis, and melanosome transfer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662306468P | 2016-03-10 | 2016-03-10 | |
| PCT/US2017/021843 WO2017156424A1 (en) | 2016-03-10 | 2017-03-10 | Malassezin and analogs thereof as skin brightening agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201807773QA true SG11201807773QA (en) | 2018-10-30 |
Family
ID=58358990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201807773QA SG11201807773QA (en) | 2016-03-10 | 2017-03-10 | Malassezin and analogs thereof as skin brightening agents |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10131631B2 (en) |
| EP (2) | EP4578512A3 (en) |
| JP (4) | JP6745365B2 (en) |
| KR (2) | KR102282974B1 (en) |
| CN (2) | CN109311884B (en) |
| AU (3) | AU2017229970B2 (en) |
| BR (1) | BR112018068293B1 (en) |
| CA (1) | CA3017352C (en) |
| DK (1) | DK3426658T3 (en) |
| EA (1) | EA201892030A1 (en) |
| ES (1) | ES3018759T3 (en) |
| FI (1) | FI3426658T3 (en) |
| HU (1) | HUE070779T2 (en) |
| IL (2) | IL287141B2 (en) |
| MA (1) | MA43730A (en) |
| MX (1) | MX393122B (en) |
| PH (1) | PH12018501926A1 (en) |
| PL (1) | PL3426658T3 (en) |
| PT (1) | PT3426658T (en) |
| SG (1) | SG11201807773QA (en) |
| WO (1) | WO2017156424A1 (en) |
| ZA (1) | ZA201806087B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102282974B1 (en) | 2016-03-10 | 2021-07-27 | 마이클 아인지거 | Malacetin and its analogues as skin brightening agents |
| MX2020010800A (en) * | 2018-04-12 | 2021-01-15 | Michael EINZIGER | PHOTOPROTECTIVE COMPOSITIONS CONTAINING <i>MALASSEZIA</i>-DERIVED COMPOUNDS AND/OR CHEMICAL ANALOGS THEREOF. |
| CA3099418A1 (en) * | 2018-05-07 | 2019-11-14 | Michael EINZIGER | Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof |
| EP3978499A1 (en) * | 2018-06-15 | 2022-04-06 | Versicolor Technologies, Llc | Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof |
| EP3841103A1 (en) * | 2018-08-24 | 2021-06-30 | Einziger, Michael | Photoprotective compositions containing malassezia-derived compounds and/or chemical analogs thereof |
| EA202092467A1 (en) * | 2018-10-08 | 2021-02-12 | Майкл Айнцигер | PHOTOPROTECTIVE COMPOSITIONS CONTAINING COMPOUNDS OBTAINED FROM MALASSEZIA AND / OR THEIR CHEMICAL ANALOGUES |
| CN118203650B (en) * | 2024-01-26 | 2025-04-29 | 上海萨丽斐生物科技有限公司 | Medicine for treating pigmentation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10109005A1 (en) * | 2001-02-23 | 2002-09-05 | Peter Mayser | Indole derivatives with an inhibitory effect on phenol oxidases |
| FR2900334B1 (en) | 2006-04-28 | 2008-06-27 | Oreal | METHOD OF DEPIGMENTING THE SKIN |
| EP2023910B1 (en) | 2006-05-03 | 2013-06-19 | Symrise AG | Ah receptor antagonists |
| EP2082736A1 (en) | 2008-01-23 | 2009-07-29 | Jean Hilaire Saurat | Pharmaceutical composition for local use |
| JP2010037251A (en) * | 2008-08-04 | 2010-02-18 | Ezaki Glico Co Ltd | Skin external preparation |
| US9969686B2 (en) | 2014-08-05 | 2018-05-15 | Wisconsin Alumni Research Foundation | Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them |
| KR102282974B1 (en) | 2016-03-10 | 2021-07-27 | 마이클 아인지거 | Malacetin and its analogues as skin brightening agents |
-
2017
- 2017-03-10 KR KR1020187029239A patent/KR102282974B1/en active Active
- 2017-03-10 IL IL287141A patent/IL287141B2/en unknown
- 2017-03-10 CN CN201780027267.1A patent/CN109311884B/en active Active
- 2017-03-10 JP JP2018567024A patent/JP6745365B2/en active Active
- 2017-03-10 AU AU2017229970A patent/AU2017229970B2/en active Active
- 2017-03-10 MA MA043730A patent/MA43730A/en unknown
- 2017-03-10 SG SG11201807773QA patent/SG11201807773QA/en unknown
- 2017-03-10 PT PT177119922T patent/PT3426658T/en unknown
- 2017-03-10 DK DK17711992.2T patent/DK3426658T3/en active
- 2017-03-10 HU HUE17711992A patent/HUE070779T2/en unknown
- 2017-03-10 US US15/455,932 patent/US10131631B2/en active Active
- 2017-03-10 EP EP25151546.6A patent/EP4578512A3/en active Pending
- 2017-03-10 EP EP17711992.2A patent/EP3426658B1/en active Active
- 2017-03-10 ES ES17711992T patent/ES3018759T3/en active Active
- 2017-03-10 KR KR1020217023318A patent/KR102453221B1/en active Active
- 2017-03-10 CA CA3017352A patent/CA3017352C/en active Active
- 2017-03-10 FI FIEP17711992.2T patent/FI3426658T3/en active
- 2017-03-10 BR BR112018068293-4A patent/BR112018068293B1/en active IP Right Grant
- 2017-03-10 WO PCT/US2017/021843 patent/WO2017156424A1/en not_active Ceased
- 2017-03-10 PL PL17711992.2T patent/PL3426658T3/en unknown
- 2017-03-10 MX MX2018010962A patent/MX393122B/en unknown
- 2017-03-10 EA EA201892030A patent/EA201892030A1/en unknown
- 2017-03-10 CN CN202110981583.0A patent/CN113698336B/en active Active
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2018
- 2018-09-04 US US16/121,353 patent/US11104644B2/en active Active
- 2018-09-10 PH PH12018501926A patent/PH12018501926A1/en unknown
- 2018-09-11 ZA ZA2018/06087A patent/ZA201806087B/en unknown
- 2018-09-12 IL IL261699A patent/IL261699B/en unknown
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2020
- 2020-08-03 JP JP2020131521A patent/JP7261771B2/en active Active
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2021
- 2021-08-23 US US17/409,702 patent/US11987555B2/en active Active
- 2021-09-15 AU AU2021232745A patent/AU2021232745B2/en active Active
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2023
- 2023-04-10 JP JP2023063407A patent/JP7642011B2/en active Active
- 2023-12-05 AU AU2023278002A patent/AU2023278002B2/en active Active
- 2023-12-08 US US18/534,253 patent/US12428374B2/en active Active
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2025
- 2025-02-25 JP JP2025028231A patent/JP2025081634A/en active Pending
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