SG11201705924RA - CRYSTALLINE FORMS OF C<sb>21</sb>H<sb>22</sb>CI<sb>2</sb>N<sb>4</sb>O<sb>2</sb> - Google Patents

CRYSTALLINE FORMS OF C<sb>21</sb>H<sb>22</sb>CI<sb>2</sb>N<sb>4</sb>O<sb>2</sb>

Info

Publication number
SG11201705924RA
SG11201705924RA SG11201705924RA SG11201705924RA SG11201705924RA SG 11201705924R A SG11201705924R A SG 11201705924RA SG 11201705924R A SG11201705924R A SG 11201705924RA SG 11201705924R A SG11201705924R A SG 11201705924RA SG 11201705924R A SG11201705924R A SG 11201705924RA
Authority
SG
Singapore
Prior art keywords
crystalline forms
crystalline
forms
Prior art date
Application number
SG11201705924RA
Other languages
English (en)
Inventor
Gary Decrescenzo
Dean Welsch
Petinka I Vlahova
Stephan X M Boerrigter
Alexander Aronov
Ali Keshavarz-Shokri
Alexander N Scangas
Kathy Stavropoulos
Benjamin Littler
Irina Nikolaevna Kadiyala
Rossitza Gueorguieva Alargova
Original Assignee
Biomed Valley Discoveries Inc
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomed Valley Discoveries Inc, Vertex Pharma filed Critical Biomed Valley Discoveries Inc
Publication of SG11201705924RA publication Critical patent/SG11201705924RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Removal Of Specific Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201705924RA 2015-01-30 2016-01-29 CRYSTALLINE FORMS OF C<sb>21</sb>H<sb>22</sb>CI<sb>2</sb>N<sb>4</sb>O<sb>2</sb> SG11201705924RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562110449P 2015-01-30 2015-01-30
PCT/US2016/015829 WO2016123574A1 (en) 2015-01-30 2016-01-29 Crystalline forms of c21h22ci2n4o2

Publications (1)

Publication Number Publication Date
SG11201705924RA true SG11201705924RA (en) 2017-08-30

Family

ID=56544441

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202101979TA SG10202101979TA (en) 2015-01-30 2016-01-29 Crystalline forms of c21h22ci2n4o2
SG11201705924RA SG11201705924RA (en) 2015-01-30 2016-01-29 CRYSTALLINE FORMS OF C<sb>21</sb>H<sb>22</sb>CI<sb>2</sb>N<sb>4</sb>O<sb>2</sb>

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202101979TA SG10202101979TA (en) 2015-01-30 2016-01-29 Crystalline forms of c21h22ci2n4o2

Country Status (11)

Country Link
US (5) US9676746B2 (es)
EP (1) EP3250562A4 (es)
JP (4) JP7258460B2 (es)
CN (2) CN107406413A (es)
AU (4) AU2016211246B2 (es)
CA (2) CA3218488A1 (es)
HK (1) HK1244274A1 (es)
MX (1) MX2017009696A (es)
NZ (2) NZ734041A (es)
SG (2) SG10202101979TA (es)
WO (1) WO2016123574A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016211246B2 (en) 2015-01-30 2020-08-27 Biomed Valley Discoveries, Inc. Crystalline forms of C21H22CI2N4O2
CN107405345A (zh) * 2016-01-27 2017-11-28 江苏恒瑞医药股份有限公司 一种含有喹啉衍生物或其盐的药物组合物的制备方法
WO2021020841A1 (en) * 2019-07-29 2021-02-04 Standigm Inc. Composition for preventing or treating metabolic liver disease
WO2021102279A1 (en) * 2019-11-20 2021-05-27 University Of Kentucky Research Foundation Anti-cancer compositions and methods
WO2023169480A1 (zh) * 2022-03-08 2023-09-14 甘李药业股份有限公司 氘代化合物,及其制备方法和应用
AU2023238106A1 (en) * 2022-03-24 2024-09-26 Biomed Valley Discoveries, Inc. Deuterated analogs of pyrrole inhibitors of erk, synthesis thereof and intermediates thereto

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599331A (en) 1984-12-24 1986-07-08 Syntex (U.S.A.) Inc. Etianic acids as antiangiogenics
WO1987002672A1 (en) 1985-10-23 1987-05-07 The Upjohn Company Tetrahydro angiostatic steroids
US4771042A (en) 1985-11-25 1988-09-13 The Upjohn Company Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments
WO1990015816A1 (en) 1989-06-16 1990-12-27 The Upjohn Company Suramin type compounds and angiostatic steroids to inhibit angiogenesis
DK0614463T3 (da) 1991-11-22 2003-03-31 Alcon Lab Inc Angiostatiske steroider
NZ514583A (en) 2000-02-05 2004-05-28 Vertex Pharma Pyrazole compositions useful as inhibitors of ERK
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7304061B2 (en) * 2002-04-26 2007-12-04 Vertex Pharmaceuticals Incorporated Heterocyclic inhibitors of ERK2 and uses thereof
AU2005245885B2 (en) 2004-05-14 2011-01-20 Vertex Pharmaceuticals, Incorporated Pyrrole compounds as inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto
US7582623B2 (en) 2004-05-20 2009-09-01 The Regents Of The University Of California Photoactive metal nitrosyls for blood pressure regulation and cancer therapy
PT2091910E (pt) 2006-12-06 2014-11-18 Conatus Pharmaceuticals Inc Formas cristalinas do ácido (3s)-3-[n-(n¿-(2-tercbutilfenil) oxamil)alaninil]amino-5-(2¿,3¿,5¿,6¿- tetrafluorofenoxi)-4-oxopentanóico
US9346800B2 (en) * 2012-09-18 2016-05-24 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
AU2016211246B2 (en) 2015-01-30 2020-08-27 Biomed Valley Discoveries, Inc. Crystalline forms of C21H22CI2N4O2

Also Published As

Publication number Publication date
JP2020100674A (ja) 2020-07-02
AU2020257041C1 (en) 2022-10-27
SG10202101979TA (en) 2021-04-29
US20200339531A1 (en) 2020-10-29
CA3218488A1 (en) 2016-08-04
AU2023254937A1 (en) 2023-11-16
HK1244274A1 (zh) 2018-08-03
US10738027B2 (en) 2020-08-11
AU2020257041A1 (en) 2020-11-12
US20220324832A1 (en) 2022-10-13
CA2975048A1 (en) 2016-08-04
AU2016211246B2 (en) 2020-08-27
NZ772411A (en) 2022-05-27
US11390600B2 (en) 2022-07-19
NZ734041A (en) 2022-02-25
EP3250562A1 (en) 2017-12-06
JP2022033866A (ja) 2022-03-02
AU2016211246A1 (en) 2017-08-10
CN107406413A (zh) 2017-11-28
CA2975048C (en) 2024-01-02
AU2022228084B2 (en) 2023-11-16
EP3250562A4 (en) 2018-07-11
US20170320851A1 (en) 2017-11-09
WO2016123574A1 (en) 2016-08-04
MX2017009696A (es) 2017-10-23
JP2018503649A (ja) 2018-02-08
JP7258460B2 (ja) 2023-04-17
US20190127348A1 (en) 2019-05-02
US9676746B2 (en) 2017-06-13
CN116854662A (zh) 2023-10-10
AU2020257041B2 (en) 2022-06-23
JP2023096080A (ja) 2023-07-06
AU2022228084A1 (en) 2022-09-29
US10183927B2 (en) 2019-01-22
US20160221987A1 (en) 2016-08-04

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