SG11201700847YA - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SG11201700847YA
SG11201700847YA SG11201700847YA SG11201700847YA SG11201700847YA SG 11201700847Y A SG11201700847Y A SG 11201700847YA SG 11201700847Y A SG11201700847Y A SG 11201700847YA SG 11201700847Y A SG11201700847Y A SG 11201700847YA SG 11201700847Y A SG11201700847Y A SG 11201700847YA
Authority
SG
Singapore
Prior art keywords
novel compounds
novel
compounds
Prior art date
Application number
SG11201700847YA
Inventor
Alison Jones
Mark Ian Kemp
Martin Lee Stockley
Karl Richard Gibson
Gavin Alistair Whitlock
Andrew Madin
Original Assignee
Mission Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB1416754.8A priority Critical patent/GB201416754D0/en
Application filed by Mission Therapeutics Ltd filed Critical Mission Therapeutics Ltd
Priority to PCT/GB2015/052729 priority patent/WO2016046530A1/en
Publication of SG11201700847YA publication Critical patent/SG11201700847YA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
SG11201700847YA 2014-09-23 2015-09-22 Novel compounds SG11201700847YA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB1416754.8A GB201416754D0 (en) 2014-09-23 2014-09-23 Novel compounds
PCT/GB2015/052729 WO2016046530A1 (en) 2014-09-23 2015-09-22 Novel compounds

Publications (1)

Publication Number Publication Date
SG11201700847YA true SG11201700847YA (en) 2017-04-27

Family

ID=51869322

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201700847YA SG11201700847YA (en) 2014-09-23 2015-09-22 Novel compounds

Country Status (14)

Country Link
US (3) US9926307B2 (en)
EP (1) EP3197883A1 (en)
JP (2) JP6549703B2 (en)
KR (1) KR20170055499A (en)
CN (1) CN107001339A (en)
AU (1) AU2015323572B2 (en)
BR (1) BR112017005887A2 (en)
CA (1) CA2958262A1 (en)
GB (1) GB201416754D0 (en)
IL (1) IL250345A (en)
MX (1) MX2017003358A (en)
RU (1) RU2691389C2 (en)
SG (1) SG11201700847YA (en)
WO (1) WO2016046530A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3157916T1 (en) 2014-06-19 2019-05-31 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
US10343992B2 (en) 2015-03-30 2019-07-09 Missions Therapeutics Limited 1-cyano-pyrrolidine compounds as USP30 inhibitors
CN107849013A (en) * 2015-07-14 2018-03-27 特殊治疗有限公司 It is used for the cyanopyrrole alkanes for the treatment of cancer as DUB inhibitor
GB201521109D0 (en) * 2015-11-30 2016-01-13 Mission Therapeutics Ltd Novel compounds
GB201522267D0 (en) * 2015-12-17 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201522768D0 (en) * 2015-12-23 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201602854D0 (en) * 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
GB201603779D0 (en) * 2016-03-04 2016-04-20 Mission Therapeutics Ltd Novel compounds
WO2017184751A1 (en) * 2016-04-20 2017-10-26 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treating and preventing hypertension
AR108326A1 (en) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-yl carboxamides and preparation and use thereof
AR108325A1 (en) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-yl carboxamides and preparation and use thereof
WO2018060689A1 (en) * 2016-09-27 2018-04-05 Mission Therapeutics Limited Cyanopyrrolidine derivatives with activity as inhibitors of usp30
GB201616511D0 (en) * 2016-09-29 2016-11-16 Mission Therapeutics Limited Novel compounds
GB201616627D0 (en) * 2016-09-30 2016-11-16 Mission Therapeutics Limited Novel compounds
TW201825475A (en) * 2016-10-05 2018-07-16 英商使命醫療公司 Novel compounds
CN110198937A (en) * 2017-02-14 2019-09-03 华东理工大学 N- (5- morpholino thiazol-2-yl) Carbox amide and its preparation method and application
AU2018265397A1 (en) * 2017-05-10 2019-11-28 Cortexyme, Inc. Aminopyridine compounds and methods for the preparation and use thereof
GB201708652D0 (en) * 2017-05-31 2017-07-12 Mission Therapeutics Ltd Novel compounds and uses
WO2018234775A1 (en) * 2017-06-20 2018-12-27 Mission Therapeutics Limited Substituted cyanopyrrolidines with activity as dub inhibitors
CN107445981B (en) * 2017-08-25 2018-06-22 牡丹江医学院 A kind of reactive compound for anti-treating cervicitis
WO2019071073A1 (en) * 2017-10-06 2019-04-11 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 30
WO2019084496A1 (en) 2017-10-27 2019-05-02 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
US20190125740A1 (en) * 2017-10-27 2019-05-02 Samumed, Llc 6-(6-membered heteroaryl & aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
WO2019185875A1 (en) 2018-03-30 2019-10-03 Syngenta Participations Ag Herbicidal compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
CA2325638A1 (en) 1998-03-26 1999-09-30 Hideki Yamada Amide derivatives and nociceptin antagonists
JP2003530384A (en) * 2000-04-06 2003-10-14 アクシス・ファーマシューティカルズ・インコーポレイテッド Cathepsin cysteine protease inhibitor
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
DE602005015833D1 (en) 2004-03-19 2009-09-17 Warner Lambert Co Imidazopyridine and imidazopyrimidine derivatives as antibacterial agents
WO2007063934A1 (en) 2005-12-02 2007-06-07 Mitsubishi Tanabe Pharma Corporation Alicyclic heterocyclic compound
WO2010052222A1 (en) 2008-11-07 2010-05-14 Evotec Neurosciences Gmbh (dihydro)naphthyridinone derivatives as histamine h3 receptor antagonists
EP2619184B1 (en) 2010-09-24 2018-05-23 The Regents of the University of Michigan Deubiquitinase inhibitors and methods for use of the same
WO2012174312A2 (en) 2011-06-15 2012-12-20 Glaxosmithkline Llc Benzimidazole derivatives as antiviral agents
PT2780326T (en) * 2011-10-19 2019-03-04 Vivolux Ab Method for inhibition of deubiquitinating activity
EP2874997A4 (en) 2012-07-19 2016-01-06 Univ Drexel Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
WO2014179755A2 (en) 2013-05-02 2014-11-06 E3X Bio Method for identifying modulators of ubiquitin ligases
US10343992B2 (en) 2015-03-30 2019-07-09 Missions Therapeutics Limited 1-cyano-pyrrolidine compounds as USP30 inhibitors
CN107849013A (en) 2015-07-14 2018-03-27 特殊治疗有限公司 It is used for the cyanopyrrole alkanes for the treatment of cancer as DUB inhibitor

Also Published As

Publication number Publication date
CA2958262A1 (en) 2016-03-31
MX2017003358A (en) 2017-09-13
RU2017105296A (en) 2018-10-24
AU2015323572A1 (en) 2017-03-23
US20190330202A1 (en) 2019-10-31
RU2017105296A3 (en) 2019-01-22
WO2016046530A1 (en) 2016-03-31
AU2015323572B2 (en) 2019-09-19
GB201416754D0 (en) 2014-11-05
CN107001339A (en) 2017-08-01
JP2019178161A (en) 2019-10-17
RU2691389C2 (en) 2019-06-13
EP3197883A1 (en) 2017-08-02
US20170247365A1 (en) 2017-08-31
JP2017530960A (en) 2017-10-19
JP6549703B2 (en) 2019-07-24
IL250345A (en) 2019-05-30
US10392380B2 (en) 2019-08-27
US20180162852A1 (en) 2018-06-14
BR112017005887A2 (en) 2017-12-12
US9926307B2 (en) 2018-03-27
KR20170055499A (en) 2017-05-19

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