SG11201610350SA - Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy - Google Patents
Expansion of lymphocytes with a cytokine composition for active cellular immunotherapyInfo
- Publication number
- SG11201610350SA SG11201610350SA SG11201610350SA SG11201610350SA SG11201610350SA SG 11201610350S A SG11201610350S A SG 11201610350SA SG 11201610350S A SG11201610350S A SG 11201610350SA SG 11201610350S A SG11201610350S A SG 11201610350SA SG 11201610350S A SG11201610350S A SG 11201610350SA
- Authority
- SG
- Singapore
- Prior art keywords
- lymphocytes
- expansion
- cellular immunotherapy
- active cellular
- cytokine composition
- Prior art date
Links
- 102000004127 Cytokines Human genes 0.000 title 1
- 108090000695 Cytokines Proteins 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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- A61K2239/54—Pancreas
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/55—IL-2
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102014211167 | 2014-06-11 | ||
PCT/EP2015/063108 WO2015189357A1 (en) | 2014-06-11 | 2015-06-11 | Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201610350SA true SG11201610350SA (en) | 2017-01-27 |
Family
ID=53546572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201610350SA SG11201610350SA (en) | 2014-06-11 | 2015-06-11 | Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy |
Country Status (19)
Country | Link |
---|---|
US (1) | US20170107490A1 (en) |
EP (2) | EP3154567B1 (en) |
JP (3) | JP7413639B2 (en) |
KR (1) | KR102441940B1 (en) |
CN (1) | CN106574244B (en) |
AU (1) | AU2015273501B2 (en) |
BR (1) | BR112016028996A2 (en) |
CA (1) | CA2951749A1 (en) |
ES (1) | ES2855475T3 (en) |
IL (1) | IL249409B (en) |
MX (1) | MX2016016251A (en) |
MY (1) | MY180750A (en) |
NZ (1) | NZ727479A (en) |
PT (1) | PT3154567T (en) |
RU (1) | RU2739770C2 (en) |
SG (1) | SG11201610350SA (en) |
UA (1) | UA123821C2 (en) |
WO (2) | WO2015189356A1 (en) |
ZA (1) | ZA201700211B (en) |
Families Citing this family (107)
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WO2015157636A1 (en) | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
IL295838A (en) * | 2015-10-30 | 2022-10-01 | Cancer Research Tech Ltd | Expansion of non-haematopoietic tissue-resident gamma delta t cells and uses of these cells |
EP3202784A1 (en) | 2016-02-08 | 2017-08-09 | Polybiocept AB | T-cell receptor sequences for active immunotherapy |
EP3453401A4 (en) * | 2016-05-06 | 2020-01-29 | Wang, Mulin | Interleukin combination and use thereof |
GB201608060D0 (en) * | 2016-05-09 | 2016-06-22 | Univ Birmingham | Method of culturing T cells |
US11472856B2 (en) | 2016-06-13 | 2022-10-18 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
CN109843921B (en) | 2016-07-07 | 2023-05-26 | 艾欧凡斯生物治疗公司 | Programmed death 1 ligand 1 (PD-L1) binding proteins and methods of use thereof |
EP3516043A1 (en) * | 2016-09-26 | 2019-07-31 | Tessa Therapeutics Pte. Ltd. | T cell expansion method |
US11026974B2 (en) | 2016-10-26 | 2021-06-08 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
TWI788307B (en) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion |
MA46916A (en) * | 2016-11-17 | 2019-09-25 | Iovance Biotherapeutics Inc | RESTTUMORINFILTRIERENDE LYMPHOZYTEN UND VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON |
US20200095547A1 (en) * | 2016-12-02 | 2020-03-26 | Darya ALIZADEH | Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors |
WO2018115146A1 (en) | 2016-12-21 | 2018-06-28 | Danmarks Tekniske Universitet | Antigen presenting scaffolds for immune-cell manipulation |
EP3565888A1 (en) | 2017-01-06 | 2019-11-13 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (tils) with tumor necrosis factor receptor superfamily (tnfrsf) agonists and therapeutic combinations of tils and tnfrsf agonists |
WO2018129336A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
JOP20190224A1 (en) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
EP3388836B1 (en) | 2017-04-12 | 2020-11-25 | polybiocept GmbH | Methods for predicting survival and treatment susceptibility of glioblastoma multiforme (gbm) patients using cytokine profiles |
EP3388073A1 (en) | 2017-04-12 | 2018-10-17 | polybliocept GmbH | Targeting mesothelin in brain cancer |
GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
CA3062874A1 (en) | 2017-05-10 | 2018-11-16 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
EP3635097A1 (en) | 2017-06-05 | 2020-04-15 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
CN111432836A (en) | 2017-09-05 | 2020-07-17 | 转矩医疗股份有限公司 | Therapeutic protein compositions and methods of making and using same |
CN107460167B (en) * | 2017-09-21 | 2020-12-15 | 山东省齐鲁细胞治疗工程技术有限公司 | Method for amplifying NK cells without trophoblasts |
JP7260553B2 (en) | 2017-10-06 | 2023-04-18 | ザ・ユニバーシティ・オブ・シカゴ | Screening of T lymphocytes against cancer-specific antigens |
JP7357613B2 (en) * | 2017-11-06 | 2023-10-06 | ラディック インスティテュート フォア キャンサー リサーチ リミテッド | How to expand lymphocytes |
JP2021503281A (en) | 2017-11-17 | 2021-02-12 | アイオバンス バイオセラピューティクス,インコーポレイテッド | TIL expansion culture from fine needle suction and small biopsy |
EP3714041A1 (en) | 2017-11-22 | 2020-09-30 | Iovance Biotherapeutics, Inc. | Expansion of peripheral blood lymphocytes (pbls) from peripheral blood |
CN108165529B (en) * | 2017-12-28 | 2021-07-16 | 北昊干细胞与再生医学研究院有限公司 | Central memory T cell body and its in vitro culture method |
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US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
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US20210137930A1 (en) * | 2018-02-13 | 2021-05-13 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists |
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WO2019210131A1 (en) | 2018-04-27 | 2019-10-31 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
WO2020021114A1 (en) | 2018-07-27 | 2020-01-30 | Nordwest Polybiocept Bioscience Gmbh | Method for the treatment of a tumor patient with adoptive t cell immunotherapy |
WO2020025706A1 (en) * | 2018-07-31 | 2020-02-06 | Polybiocept Gmbh | Production and selection of tumor uber reactive immune cells (turics) |
US20210171909A1 (en) * | 2018-08-31 | 2021-06-10 | Novartis Ag | Methods of making chimeric antigen receptor?expressing cells |
TW202031273A (en) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | Treatment of nsclc patients refractory for anti-pd-1 antibody |
IL281423B1 (en) | 2018-09-20 | 2024-04-01 | Iovance Biotherapeutics Inc | Expansion of tils from cryopreserved tumor samples |
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