SG11201600159TA - Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof - Google Patents

Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof

Info

Publication number
SG11201600159TA
SG11201600159TA SG11201600159TA SG11201600159TA SG11201600159TA SG 11201600159T A SG11201600159T A SG 11201600159TA SG 11201600159T A SG11201600159T A SG 11201600159TA SG 11201600159T A SG11201600159T A SG 11201600159TA SG 11201600159T A SG11201600159T A SG 11201600159TA
Authority
SG
Singapore
Prior art keywords
pyrazines
pyridines
pyrimidines
uses
btk inhibitors
Prior art date
Application number
SG11201600159TA
Inventor
Lesley Liu-Bujalski
Ngan Nguyen
Hui Qiu
Reinaldo Jones
Igor Mochalkin
richard d Caldwell
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361860401P priority Critical
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Priority to PCT/US2014/048810 priority patent/WO2015017502A1/en
Publication of SG11201600159TA publication Critical patent/SG11201600159TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y02A50/38Medical treatment of vector-borne diseases characterised by the agent
    • Y02A50/398Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a bacteria
    • Y02A50/399Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a bacteria of the genus Borrellia
    • Y02A50/401Medical treatment of vector-borne diseases characterised by the agent the vector-borne disease being caused by a bacteria of the genus Borrellia the bacteria being Borrelia burgdorferi, i.e. Lyme disease or Lyme borreliosis
SG11201600159TA 2013-07-31 2014-07-30 Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof SG11201600159TA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201361860401P true 2013-07-31 2013-07-31
PCT/US2014/048810 WO2015017502A1 (en) 2013-07-31 2014-07-30 Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
SG11201600159TA true SG11201600159TA (en) 2016-02-26

Family

ID=51303133

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201600159TA SG11201600159TA (en) 2013-07-31 2014-07-30 Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
SG10201900025UA SG10201900025UA (en) 2013-07-31 2014-07-30 Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201900025UA SG10201900025UA (en) 2013-07-31 2014-07-30 Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof

Country Status (21)

Country Link
US (2) US9738648B2 (en)
EP (1) EP3049417B1 (en)
KR (1) KR20160036053A (en)
CN (1) CN105814057B (en)
AU (1) AU2014296261B2 (en)
CA (1) CA2918242A1 (en)
DK (1) DK3049417T3 (en)
ES (1) ES2706150T3 (en)
HR (1) HRP20190054T1 (en)
HU (1) HUE042111T2 (en)
IL (1) IL243844A (en)
LT (1) LT3049417T (en)
MX (1) MX2016001146A (en)
PL (1) PL3049417T3 (en)
PT (1) PT3049417T (en)
RS (1) RS58361B1 (en)
RU (1) RU2016106760A (en)
SG (2) SG11201600159TA (en)
SI (1) SI3049417T1 (en)
WO (1) WO2015017502A1 (en)
ZA (1) ZA201600564B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35464A (en) 2013-03-15 2014-10-31 Araxes Pharma Llc KRAS G12C covalent inhibitors.
TWI659021B (en) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Inhibitors of kras g12c
EA201792214A1 (en) 2015-04-10 2018-01-31 Араксис Фарма Ллк Compounds of substitute quinazoline
JP2018511631A (en) 2015-04-15 2018-04-26 アラクセス ファーマ エルエルシー Fused tricyclic inhibitors of KRAS and methods of use thereof
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
AU2016355433A1 (en) 2015-11-16 2018-06-28 Araxes Pharma Llc 2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
CN107021963A (en) 2016-01-29 2017-08-08 北京诺诚健华医药科技有限公司 Pyrazole fused ring analog derivative, its preparation method and its application in treating cancer, inflammation and immunity disease
CN109641892A (en) * 2016-08-16 2019-04-16 默克专利有限公司 2- oxo-imidazol as reversible BTK inhibitor and pyridine and application thereof
US10280172B2 (en) 2016-09-29 2019-05-07 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
CN110312711A (en) 2016-10-07 2019-10-08 亚瑞克西斯制药公司 Heterocyclic compound and its application method as RAS inhibitor
CN106831787B (en) * 2017-01-20 2018-10-23 成都倍特药业有限公司 Compound and its preparation method and application as bruton's tyrosine kinase inhibitor
EP3573971A1 (en) * 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US7507740B2 (en) * 2004-06-02 2009-03-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CN101031570B (en) * 2004-07-30 2012-09-05 梅特希尔基因公司 Inhibitors of VEGF receptor and HGF receptor signaling
TW200740820A (en) * 2005-07-05 2007-11-01 Takeda Pharmaceuticals Co Fused heterocyclic derivatives and use thereof
GB0708141D0 (en) * 2007-04-26 2007-06-06 Syngenta Participations Ag Improvements in or relating to organic compounds
KR101483215B1 (en) * 2010-01-29 2015-01-16 한미약품 주식회사 Bicyclic heteroaryl derivatives having inhibitory activity for protein kinases
CA2836417A1 (en) * 2011-05-17 2012-11-22 Principia Biopharma Inc. Azaindole derivatives as tyrosine kinase inhibitors
WO2012158795A1 (en) * 2011-05-17 2012-11-22 Principia Biopharma Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
EP3495368A1 (en) * 2011-07-19 2019-06-12 Merck Sharp & Dohme B.V. (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-2-methoxy-n-(pyridin-2-yl)benzamide as btk-inhibitor
EP2548877A1 (en) * 2011-07-19 2013-01-23 MSD Oss B.V. 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
EP2760863A1 (en) * 2011-09-20 2014-08-06 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors

Also Published As

Publication number Publication date
US20170226113A1 (en) 2017-08-10
PL3049417T3 (en) 2019-03-29
JP2016531119A (en) 2016-10-06
CN105814057B (en) 2019-05-03
SI3049417T1 (en) 2019-03-29
PT3049417T (en) 2019-01-24
MX2016001146A (en) 2016-04-29
US10005784B2 (en) 2018-06-26
EP3049417A1 (en) 2016-08-03
US9738648B2 (en) 2017-08-22
DK3049417T3 (en) 2019-01-14
IL243844D0 (en) 2016-04-21
KR20160036053A (en) 2016-04-01
US20160159804A1 (en) 2016-06-09
CA2918242A1 (en) 2015-02-05
AU2014296261A1 (en) 2016-02-11
RS58361B1 (en) 2019-03-29
HUE042111T2 (en) 2019-06-28
WO2015017502A1 (en) 2015-02-05
HRP20190054T1 (en) 2019-02-22
SG10201900025UA (en) 2019-02-27
AU2014296261B2 (en) 2018-11-15
RU2016106760A (en) 2017-09-04
CN105814057A (en) 2016-07-27
EP3049417B1 (en) 2018-10-17
ZA201600564B (en) 2019-04-24
IL243844A (en) 2019-10-31
ES2706150T3 (en) 2019-03-27
LT3049417T (en) 2019-02-11

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