SG11201505383UA - Non-human animals with modified immunoglobulin heavy chain sequences - Google Patents

Non-human animals with modified immunoglobulin heavy chain sequences

Info

Publication number
SG11201505383UA
SG11201505383UA SG11201505383UA SG11201505383UA SG11201505383UA SG 11201505383U A SG11201505383U A SG 11201505383UA SG 11201505383U A SG11201505383U A SG 11201505383UA SG 11201505383U A SG11201505383U A SG 11201505383UA SG 11201505383U A SG11201505383U A SG 11201505383UA
Authority
SG
Singapore
Prior art keywords
non
heavy chain
immunoglobulin heavy
human animals
chain sequences
Prior art date
Application number
SG11201505383UA
Inventor
John Mcwhirter
Cagan Gurer
Karolina A Meagher
Lynn Macdonald
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361766765P priority Critical
Priority to US201361879338P priority
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Priority to PCT/US2014/017427 priority patent/WO2014130690A1/en
Publication of SG11201505383UA publication Critical patent/SG11201505383UA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027New breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278Humanized animals, e.g. knockin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
SG11201505383UA 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences SG11201505383UA (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US201361766765P true 2013-02-20 2013-02-20
US201361879338P true 2013-09-18 2013-09-18
PCT/US2014/017427 WO2014130690A1 (en) 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences

Publications (1)

Publication Number Publication Date
SG11201505383UA true SG11201505383UA (en) 2015-08-28

Family

ID=51389721

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201505383UA SG11201505383UA (en) 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences
SG10201900580RA SG10201900580RA (en) 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences
SG10201600539UA SG10201600539UA (en) 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201900580RA SG10201900580RA (en) 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences
SG10201600539UA SG10201600539UA (en) 2013-02-20 2014-02-20 Non-human animals with modified immunoglobulin heavy chain sequences

Country Status (22)

Country Link
US (3) US20140245468A1 (en)
EP (2) EP3351095A1 (en)
JP (3) JP5993102B2 (en)
KR (2) KR20160025033A (en)
CN (2) CN105734081A (en)
AU (3) AU2014218915B2 (en)
CA (1) CA2897963A1 (en)
DK (1) DK2840892T3 (en)
ES (1) ES2678221T3 (en)
HK (1) HK1207251A1 (en)
HR (1) HRP20181151T1 (en)
HU (1) HUE039214T2 (en)
IL (3) IL239905A (en)
LT (1) LT2840892T (en)
MX (1) MX355105B (en)
PL (1) PL2840892T3 (en)
RS (1) RS57582B1 (en)
RU (2) RU2017114166A (en)
SG (3) SG11201505383UA (en)
SI (1) SI2840892T1 (en)
TR (1) TR201810255T4 (en)
WO (1) WO2014130690A1 (en)

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JP2017529841A (en) 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. Chimeric antigen receptor
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SG11201810757YA (en) 2016-06-03 2018-12-28 Regeneron Pharma Non-human animals expressing exogenous terminal deoxynucleotidyltransferase

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Also Published As

Publication number Publication date
CN105734081A (en) 2016-07-06
US20140245468A1 (en) 2014-08-28
SG10201600539UA (en) 2016-02-26
JP2016127840A (en) 2016-07-14
JP2016513957A (en) 2016-05-19
MX355105B (en) 2018-04-05
MX2015010832A (en) 2016-02-09
ES2678221T3 (en) 2018-08-09
CN104994730B (en) 2018-12-28
HRP20181151T1 (en) 2018-09-21
EP2840892A4 (en) 2015-09-30
AU2016269388A1 (en) 2016-12-22
KR101764800B1 (en) 2017-08-04
EP3351095A1 (en) 2018-07-25
SI2840892T1 (en) 2018-08-31
AU2016269388B2 (en) 2018-11-08
IL239905A (en) 2017-04-30
DK2840892T3 (en) 2018-07-23
HK1207251A1 (en) 2016-01-29
EP2840892A1 (en) 2015-03-04
CN104994730A (en) 2015-10-21
US20150020224A1 (en) 2015-01-15
RU2618886C2 (en) 2017-05-11
JP5993102B2 (en) 2016-09-14
KR20150118135A (en) 2015-10-21
US20170135326A9 (en) 2017-05-18
RS57582B1 (en) 2018-11-30
EP2840892B1 (en) 2018-04-18
IL257303D0 (en) 2018-04-09
WO2014130690A1 (en) 2014-08-28
US9204624B2 (en) 2015-12-08
AU2019200538A1 (en) 2019-02-14
US20160100561A1 (en) 2016-04-14
KR20160025033A (en) 2016-03-07
IL250460A (en) 2018-02-28
RU2017114166A (en) 2019-01-29
TR201810255T4 (en) 2018-08-27
JP6473423B2 (en) 2019-02-20
AU2014218915A1 (en) 2015-08-13
US9930871B2 (en) 2018-04-03
CA2897963A1 (en) 2014-08-28
SG10201900580RA (en) 2019-02-27
JP2018164465A (en) 2018-10-25
PL2840892T3 (en) 2018-09-28
IL239905D0 (en) 2015-08-31
RU2015135884A (en) 2017-03-22
LT2840892T (en) 2018-07-25
AU2014218915B2 (en) 2017-01-19
HUE039214T2 (en) 2018-12-28

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