SG11201502183XA - In vitro pancreatic differentiation of pluripotent mammalian cells - Google Patents
In vitro pancreatic differentiation of pluripotent mammalian cellsInfo
- Publication number
- SG11201502183XA SG11201502183XA SG11201502183XA SG11201502183XA SG11201502183XA SG 11201502183X A SG11201502183X A SG 11201502183XA SG 11201502183X A SG11201502183X A SG 11201502183XA SG 11201502183X A SG11201502183X A SG 11201502183XA SG 11201502183X A SG11201502183X A SG 11201502183XA
- Authority
- SG
- Singapore
- Prior art keywords
- mammalian cells
- pancreatic differentiation
- pluripotent mammalian
- vitro pancreatic
- vitro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/507—Pancreatic cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1216796.1A GB201216796D0 (en) | 2012-09-20 | 2012-09-20 | In vitro pancreatic differentiation |
PCT/EP2013/069188 WO2014044646A1 (en) | 2012-09-20 | 2013-09-16 | In vitro pancreatic differentiation of pluripotent mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201502183XA true SG11201502183XA (en) | 2015-05-28 |
Family
ID=47190333
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201502183XA SG11201502183XA (en) | 2012-09-20 | 2013-09-16 | In vitro pancreatic differentiation of pluripotent mammalian cells |
SG10201702239XA SG10201702239XA (en) | 2012-09-20 | 2013-09-16 | In vitro pancreatic differentiation of pluripotent mammalian cells |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201702239XA SG10201702239XA (en) | 2012-09-20 | 2013-09-16 | In vitro pancreatic differentiation of pluripotent mammalian cells |
Country Status (10)
Country | Link |
---|---|
US (1) | US9790470B2 (en) |
EP (1) | EP2898063B1 (en) |
JP (1) | JP6463681B2 (en) |
CN (1) | CN104755607B (en) |
AU (1) | AU2013320408A1 (en) |
CA (1) | CA2924511C (en) |
DK (1) | DK2898063T3 (en) |
GB (1) | GB201216796D0 (en) |
SG (2) | SG11201502183XA (en) |
WO (1) | WO2014044646A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
US10174289B2 (en) | 2014-05-28 | 2019-01-08 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
US9371516B2 (en) | 2014-09-19 | 2016-06-21 | Regenerative Medical Solutions, Inc. | Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells |
US11584916B2 (en) | 2014-10-17 | 2023-02-21 | Children's Hospital Medical Center | Method of making in vivo human small intestine organoids from pluripotent stem cells |
GB201510950D0 (en) | 2015-06-22 | 2015-08-05 | Cambridge Entpr Ltd | In vitro Production of Cholangiocytes |
CN106467918B (en) * | 2015-08-18 | 2020-07-31 | 中国科学技术大学先进技术研究院 | Induction method and application of insulin secreting cells based on human skin cells |
EP3411472A4 (en) | 2016-02-01 | 2020-01-22 | Cedars-Sinai Medical Center | Systems and methods for growth of intestinal cells in microfluidic devices |
ES2929758T3 (en) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Methods for the in vitro manufacture of gastric fundus tissue and compositions related thereto |
CN107349193A (en) * | 2016-05-10 | 2017-11-17 | 北京市神经外科研究所 | Purposes of the protein function inhibitor DAPT in the medicine for preparing treatment endocrine system disease |
KR102558606B1 (en) | 2016-12-05 | 2023-07-26 | 칠드런즈 호스피탈 메디칼 센터 | Colon organ organ and methods of making and using the same |
SG11201906225PA (en) * | 2017-01-17 | 2019-08-27 | Agency Science Tech & Res | Maintenance and expansion of pancreatic progenitor cells |
WO2018140647A1 (en) | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
US11414648B2 (en) | 2017-03-24 | 2022-08-16 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CN111094547B (en) * | 2017-06-14 | 2024-02-09 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心(有限公司) | Method for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
EP3768823A4 (en) * | 2018-03-23 | 2022-03-09 | Cedars-Sinai Medical Center | Methods of use of islet cells |
CN112888778A (en) * | 2018-10-15 | 2021-06-01 | Cynity株式会社 | Method for producing stem/progenitor cells from cells derived from an endosymbiont tissue or organ by means of a low-molecular compound |
CN111607556B (en) * | 2019-01-25 | 2022-06-07 | 中国科学院广州生物医药与健康研究院 | Culture medium for culturing and amplifying human hepatic progenitor cells and application thereof |
WO2020207998A1 (en) * | 2019-04-08 | 2020-10-15 | Novo Nordisk A/S | Generation of pancreatic endoderm from stem cell derived definitive endoderm |
EP3972990A4 (en) * | 2019-05-22 | 2023-10-11 | The Cleveland Clinic Foundation | Generating dorsal foregut, and anterior domain, endoderm cells |
KR20220098914A (en) * | 2021-01-05 | 2022-07-12 | 재단법인 아산사회복지재단 | Method for differentiation of insulin-producing cells using ionized atelocollagen, and artificial pancreas manufactured by the same method |
CN113046299A (en) * | 2021-03-19 | 2021-06-29 | 上海爱萨尔生物科技有限公司 | Additive for preparing islet beta cells by inducing pluripotent stem cells to differentiate directionally |
CN112961823B (en) * | 2021-03-19 | 2024-01-23 | 上海爱萨尔生物科技有限公司 | Culture solution for preparing islet beta cells by inducing directional differentiation of pluripotent stem cells |
CN113234664A (en) * | 2021-05-11 | 2021-08-10 | 澳门大学 | Preparation method and application of pancreatic progenitor cells |
WO2023097513A1 (en) * | 2021-11-30 | 2023-06-08 | Hangzhou Reprogenix Bioscience, Inc. | Method of generating functional islets from pluripotent stem cells |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6436704B1 (en) * | 2000-04-10 | 2002-08-20 | Raven Biotechnologies, Inc. | Human pancreatic epithelial progenitor cells and methods of isolation and use thereof |
KR101008868B1 (en) * | 2001-12-07 | 2011-01-17 | 제론 코포레이션 | Islet cells from human embryonic stem cells |
JP5131833B2 (en) * | 2005-10-05 | 2013-01-30 | 晃文 松山 | Method for obtaining pancreatic endocrine cells from adipose tissue-derived cells |
GB0622394D0 (en) | 2006-11-09 | 2006-12-20 | Univ Cambridge Tech | Differentiation of pluripotent cells |
CN101861386A (en) * | 2007-07-18 | 2010-10-13 | 生命扫描有限公司 | The differentiation of human embryo stem cell |
CN107574142B (en) * | 2007-11-27 | 2021-07-06 | 生命扫描有限公司 | Differentiation of human embryonic stem cells |
WO2010002785A1 (en) * | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
US9234178B2 (en) * | 2008-10-31 | 2016-01-12 | Janssen Biotech, Inc. | Differentiation of human pluripotent stem cells |
WO2010091241A2 (en) * | 2009-02-06 | 2010-08-12 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of definitive endoderm |
EP2233566A1 (en) * | 2009-03-17 | 2010-09-29 | Vrije Universiteit Brussel | Generation of pancreatic progenitor cells |
JP6219568B2 (en) * | 2009-07-20 | 2017-10-25 | ヤンセン バイオテツク,インコーポレーテツド | Differentiation of human embryonic stem cells |
SG10201502242VA (en) * | 2010-03-23 | 2015-05-28 | Kuraray Co | Culture method for causing differentiation of pluripotent mammalian cells |
RU2587634C2 (en) * | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Differentiation of human embryo stem cells |
KR101877077B1 (en) * | 2010-08-09 | 2018-07-10 | 다케다 야쿠힌 고교 가부시키가이샤 | Method of producing pancreatic hormone-producing cells |
GB201014169D0 (en) | 2010-08-25 | 2010-10-06 | Cambridge Entpr Ltd | In vitro hepatic differentiation |
WO2012170853A1 (en) | 2011-06-10 | 2012-12-13 | Wisconsin Alumni Research Foundation ("Warf") | Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage |
-
2012
- 2012-09-20 GB GBGB1216796.1A patent/GB201216796D0/en not_active Ceased
-
2013
- 2013-09-16 CA CA2924511A patent/CA2924511C/en active Active
- 2013-09-16 AU AU2013320408A patent/AU2013320408A1/en not_active Abandoned
- 2013-09-16 DK DK13765696.3T patent/DK2898063T3/en active
- 2013-09-16 US US14/429,869 patent/US9790470B2/en active Active
- 2013-09-16 JP JP2015532382A patent/JP6463681B2/en active Active
- 2013-09-16 WO PCT/EP2013/069188 patent/WO2014044646A1/en active Application Filing
- 2013-09-16 SG SG11201502183XA patent/SG11201502183XA/en unknown
- 2013-09-16 EP EP13765696.3A patent/EP2898063B1/en active Active
- 2013-09-16 SG SG10201702239XA patent/SG10201702239XA/en unknown
- 2013-09-16 CN CN201380055066.4A patent/CN104755607B/en active Active
Also Published As
Publication number | Publication date |
---|---|
SG10201702239XA (en) | 2017-04-27 |
AU2013320408A1 (en) | 2015-05-07 |
DK2898063T3 (en) | 2019-01-28 |
JP6463681B2 (en) | 2019-02-06 |
JP2015535175A (en) | 2015-12-10 |
EP2898063A1 (en) | 2015-07-29 |
CN104755607B (en) | 2019-02-12 |
US9790470B2 (en) | 2017-10-17 |
WO2014044646A1 (en) | 2014-03-27 |
CA2924511C (en) | 2021-05-25 |
US20150225698A1 (en) | 2015-08-13 |
EP2898063B1 (en) | 2018-11-07 |
CA2924511A1 (en) | 2014-03-27 |
CN104755607A (en) | 2015-07-01 |
GB201216796D0 (en) | 2012-11-07 |
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