SG11201406080VA - SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE - Google Patents
SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINEInfo
- Publication number
- SG11201406080VA SG11201406080VA SG11201406080VA SG11201406080VA SG11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA SG 11201406080V A SG11201406080V A SG 11201406080VA
- Authority
- SG
- Singapore
- Prior art keywords
- arabinofuranosyl
- deoxy
- cytosine
- thio
- fluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/19—Purine radicals with arabinosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012074525 | 2012-03-28 | ||
JP2013050846 | 2013-03-13 | ||
PCT/JP2013/058896 WO2013146833A1 (ja) | 2012-03-28 | 2013-03-27 | 1-(2-デオキシ-2-フルオロ-4-チオ-β-D-アラビノフラノシル)シトシンの塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201406080VA true SG11201406080VA (en) | 2014-11-27 |
Family
ID=49260082
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201603288XA SG10201603288XA (en) | 2012-03-28 | 2013-03-27 | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine |
SG11201406080VA SG11201406080VA (en) | 2012-03-28 | 2013-03-27 | SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201603288XA SG10201603288XA (en) | 2012-03-28 | 2013-03-27 | Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine |
Country Status (19)
Country | Link |
---|---|
US (1) | US9896471B2 (ja) |
EP (1) | EP2832740B1 (ja) |
JP (1) | JP5833225B2 (ja) |
KR (2) | KR20170082650A (ja) |
CN (1) | CN104203969B (ja) |
AU (1) | AU2013241341B2 (ja) |
BR (1) | BR112014020416B1 (ja) |
CA (2) | CA2943998C (ja) |
DK (1) | DK2832740T3 (ja) |
ES (1) | ES2730679T3 (ja) |
HK (1) | HK1201273A1 (ja) |
IL (1) | IL234222A (ja) |
MX (2) | MX370733B (ja) |
NZ (1) | NZ701245A (ja) |
PL (1) | PL2832740T3 (ja) |
RU (1) | RU2600734C2 (ja) |
SG (2) | SG10201603288XA (ja) |
TW (1) | TWI637963B (ja) |
WO (1) | WO2013146833A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2718307T3 (es) | 2012-08-13 | 2019-07-01 | Fujifilm Corp | Intermedio para la síntesis de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil)citosina, intermedio para la síntesis de tionucleósido y métodos para producir estos intermedios |
JP6175553B2 (ja) | 2014-02-18 | 2017-08-09 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
TWI678373B (zh) | 2014-10-31 | 2019-12-01 | 日商富士軟片股份有限公司 | 硫代核苷衍生物或其鹽及醫藥組合物 |
JP6450356B2 (ja) | 2016-02-29 | 2019-01-09 | 富士フイルム株式会社 | 液状医薬製剤 |
MX2019002430A (es) | 2016-08-31 | 2019-07-04 | Fujifilm Corp | Agente antitumoral, mejorador del efecto antitumoral, y kit antitumoral. |
CA3089728C (en) | 2018-01-29 | 2023-01-10 | Fujifilm Corporation | Antitumor agent for biliary tract cancer and method for treating biliary tract cancer |
TW202002989A (zh) * | 2018-03-13 | 2020-01-16 | 日商富士軟片股份有限公司 | 抗腫瘤劑、抗腫瘤效果增強劑及抗腫瘤用試劑盒 |
CN112888698A (zh) | 2018-09-25 | 2021-06-01 | 美国政府(由卫生和人类服务部的部长所代表) | 2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法 |
KR102106096B1 (ko) | 2019-08-19 | 2020-04-29 | 이명준 | 경추 지압 마사지기 |
CN117794548A (zh) | 2021-07-29 | 2024-03-29 | 富士胶片株式会社 | 针对bap1及pbrm1中的至少一个的功能下降的肿瘤的药物组合物及抗肿瘤剂 |
KR102454186B1 (ko) | 2022-05-23 | 2022-10-14 | 이명준 | 경추 지압장치 |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3116282A (en) * | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
US3243425A (en) | 1962-10-29 | 1966-03-29 | Purdue Research Foundation | Novel sulfur-containing compounds |
JPS5148682A (ja) * | 1974-10-15 | 1976-04-26 | Asahi Chemical Ind | Nukureochidojudotainoseiho |
JPS53119810A (en) | 1977-03-25 | 1978-10-19 | Mitsubishi Chem Ind Ltd | Preparation of aldehyde chloride |
US4211773A (en) * | 1978-10-02 | 1980-07-08 | Sloan Kettering Institute For Cancer Research | 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides |
US4220774A (en) | 1978-10-26 | 1980-09-02 | Omnium Chimique | Vincadifformine synthesis process |
JPS5692239A (en) | 1979-12-27 | 1981-07-25 | Sagami Chem Res Center | Preparation of 5-oxohexyl compound |
US4803272A (en) | 1987-02-24 | 1989-02-07 | E. I. Du Pont De Nemours And Company | S-modified adenosyl-1,8-diamino-3-thiooctane derivatives |
IE74701B1 (en) | 1989-10-04 | 1997-07-30 | Univ Birmingham | Further antiviral pyrimidine nucleosides |
SE9003151D0 (sv) | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
FI105556B (fi) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta |
JP3138834B2 (ja) | 1991-12-26 | 2001-02-26 | 生化学工業株式会社 | フコピラノース類縁体の製造方法およびその合成中間化合物 |
GB9218810D0 (en) | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
GB9515279D0 (en) * | 1995-07-25 | 1995-09-20 | Norsk Hydro As | Improved therapeutic agents |
EP0770621A4 (en) | 1994-07-12 | 1998-01-28 | Yamasa Corp | 2'-DESOXY-2 '- (METHYLIDENE SUBSTITUTED OR NON-SUBSTITUTED) -4'-THIONUCLEOSIDE |
JPH0853490A (ja) | 1994-08-09 | 1996-02-27 | Yamasa Shoyu Co Ltd | 2’−デオキシ−2’,2’−ジハロゲノ−4’−チオヌクレオシド |
EP0839813A1 (en) | 1996-04-09 | 1998-05-06 | Yamasa Corporation | 9-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)purine derivatives |
JP4202327B2 (ja) | 1996-04-09 | 2008-12-24 | ヤマサ醤油株式会社 | 1−(2−デオキシ−2−フルオロ−4−チオ−β−D−アラビノフラノシル)シトシン |
WO1997038001A1 (fr) * | 1996-04-09 | 1997-10-16 | Yamasa Corporation | 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES |
US7875733B2 (en) | 2003-09-18 | 2011-01-25 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation |
HUP9601756A3 (en) | 1996-06-25 | 1999-05-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical compositions containing them |
JP4087471B2 (ja) | 1997-03-31 | 2008-05-21 | 大日本印刷株式会社 | 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法 |
HUP9702348A3 (en) | 1997-12-04 | 2000-12-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them |
WO1999043690A1 (fr) | 1998-02-25 | 1999-09-02 | Rational Drug Design Laboratories | Compose de l-4'-arabinofuranonucleoside et composition medicinale le contenant |
ES2402799T3 (es) | 1998-07-23 | 2013-05-09 | Southern Research Institute | Prepreparación de compuestos de tioarabinofuranosilo y utilización de los mismos |
WO2001066118A1 (en) | 2000-03-08 | 2001-09-13 | Southern Research Institute | 4'-thio-l-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof |
KR100426030B1 (ko) | 2000-07-22 | 2004-04-03 | (주) 한켐 | 락톤계 당화합물에서의 키랄성 전환방법 |
TWI247609B (en) | 2001-01-23 | 2006-01-21 | Nihon Mediphysics Co Ltd | Agent for diagnosis of tissue proliferation activity or the treatment of proliferative disease |
KR20050059975A (ko) | 2001-06-22 | 2005-06-21 | 파마셋 인코포레이티드 | β-2'- 또는 3'-할로뉴클레오시드 |
JP2003172990A (ja) | 2001-08-03 | 2003-06-20 | Fuji Photo Film Co Ltd | ハロゲン化銀乳剤及びハロゲン化銀写真感光材料 |
WO2004014930A1 (ja) | 2002-08-09 | 2004-02-19 | Taisho Pharmaceutical Co., Ltd. | 選択的なアリール5−チオ−β−D−アルドヘキソピラノシドの製造法 |
AU2003200960B2 (en) | 2002-09-18 | 2005-01-06 | Mackinnon, Sebastian Mr | System for Ordering, Tracking and Payment of Goods and Services |
AU2004238329A1 (en) | 2003-05-12 | 2004-11-25 | Purdue Research Foundation | Cytotoxic indeno and isoindoloisoquinolones |
WO2004106280A1 (ja) | 2003-05-28 | 2004-12-09 | Japan Tobacco Inc. | CaSRアンタゴニスト |
WO2004106352A1 (ja) | 2003-05-29 | 2004-12-09 | Taisho Pharmaceutical Co., Ltd. | アルドヘキソピラノース中間体の製造法 |
GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
TW200637839A (en) | 2005-01-07 | 2006-11-01 | Taisho Pharmaceutical Co Ltd | 1-thio-d-glucitol derivatives |
ATE516026T1 (de) | 2005-02-21 | 2011-07-15 | Shionogi & Co | Bicyclisches carbamoylpyridonderivat mit hiv- integrase-hemmender wirkung |
JP2006335737A (ja) | 2005-06-03 | 2006-12-14 | Ihara Nikkei Kagaku Kogyo Kk | ベンゾ[c]ヘテロ5員環化合物の製造方法 |
US20090069263A1 (en) | 2005-12-16 | 2009-03-12 | Damha Masad J | 4'-thioarabinonucleotide-containing oligonucleotides, compounds and methods for their preparation and uses thereof |
CN100513395C (zh) | 2006-04-17 | 2009-07-15 | 中国科学院化学研究所 | 一种制备多羟基环状硝酮的方法 |
EP2012799B1 (en) * | 2006-05-03 | 2016-08-24 | Chimerix, Inc. | Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates |
CN101200463B (zh) | 2007-12-11 | 2011-06-22 | 复旦大学 | 全酰化-4-硫代-d-核糖及其制备方法 |
US8859589B2 (en) | 2008-03-12 | 2014-10-14 | Southern Research Institute | Use of 4′-thio-2′-deoxynucleosides as anti orthopoxvirus agents |
CN101880287B (zh) | 2009-05-05 | 2012-07-25 | 上海医药工业研究院 | 一类四氢噻吩核苷类似物的中间体化合物及其制备方法 |
RU2538593C2 (ru) * | 2009-05-15 | 2015-01-10 | Дельта-Флай Фарма, Инк. | НОВЫЕ СТАБИЛЬНЫЕ КРИСТАЛЛЫ МОНОГИДРОХЛОРИДА 1-(2-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА |
BR112012014490B1 (pt) | 2009-12-18 | 2021-07-13 | Libramedicina, Inc | Processos para a preparação de 1-o-acil-2-desóxi-2-fluoro-4-tio-?-d-arabinofuranoses e compostos intermediários dos mesmos |
GB201016855D0 (en) | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
DE102010042013A1 (de) | 2010-10-06 | 2012-04-12 | Robert Bosch Gmbh | Verfahren zur Einstellung einer Temperatur eines Sensorelements |
JP5776564B2 (ja) | 2012-01-20 | 2015-09-09 | 日本精工株式会社 | ワーク処理装置、及びワーク処理方法 |
US20140029864A1 (en) | 2012-07-30 | 2014-01-30 | Dror Reif | Compression encoding and decoding method and apparatus |
ES2718307T3 (es) | 2012-08-13 | 2019-07-01 | Fujifilm Corp | Intermedio para la síntesis de 1-(2-desoxi-2-fluoro-4-tio-beta-d-arabinofuranosil)citosina, intermedio para la síntesis de tionucleósido y métodos para producir estos intermedios |
JP6175553B2 (ja) | 2014-02-18 | 2017-08-09 | 富士フイルム株式会社 | チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物 |
JP6204223B2 (ja) | 2014-02-19 | 2017-09-27 | 富士フイルム株式会社 | チオピラノース化合物等の製造方法 |
WO2016155593A1 (zh) | 2015-04-03 | 2016-10-06 | 四川科伦药物研究院有限公司 | 4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用 |
-
2013
- 2013-03-27 KR KR1020177018337A patent/KR20170082650A/ko not_active Application Discontinuation
- 2013-03-27 DK DK13770090.2T patent/DK2832740T3/da active
- 2013-03-27 PL PL13770090T patent/PL2832740T3/pl unknown
- 2013-03-27 MX MX2017008865A patent/MX370733B/es unknown
- 2013-03-27 KR KR1020147030209A patent/KR101770246B1/ko active IP Right Grant
- 2013-03-27 JP JP2014507938A patent/JP5833225B2/ja active Active
- 2013-03-27 ES ES13770090T patent/ES2730679T3/es active Active
- 2013-03-27 BR BR112014020416-0A patent/BR112014020416B1/pt active IP Right Grant
- 2013-03-27 SG SG10201603288XA patent/SG10201603288XA/en unknown
- 2013-03-27 WO PCT/JP2013/058896 patent/WO2013146833A1/ja active Application Filing
- 2013-03-27 RU RU2014143277/04A patent/RU2600734C2/ru active
- 2013-03-27 NZ NZ701245A patent/NZ701245A/en unknown
- 2013-03-27 CA CA2943998A patent/CA2943998C/en active Active
- 2013-03-27 TW TW102110915A patent/TWI637963B/zh active
- 2013-03-27 SG SG11201406080VA patent/SG11201406080VA/en unknown
- 2013-03-27 CN CN201380016308.9A patent/CN104203969B/zh active Active
- 2013-03-27 AU AU2013241341A patent/AU2013241341B2/en active Active
- 2013-03-27 CA CA2865742A patent/CA2865742C/en active Active
- 2013-03-27 MX MX2014011182A patent/MX352423B/es active IP Right Grant
- 2013-03-27 EP EP13770090.2A patent/EP2832740B1/en active Active
-
2014
- 2014-08-21 IL IL234222A patent/IL234222A/en active IP Right Grant
- 2014-09-26 US US14/498,334 patent/US9896471B2/en active Active
-
2015
- 2015-02-17 HK HK15101764.5A patent/HK1201273A1/zh unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL273276A (en) | salt crystals | |
HK1201273A1 (zh) | -β- -脫氧- -氟- -硫代-β- -阿拉伯呋喃糖基 胞嘧啶的鹽 | |
HK1215023A1 (zh) | 雜環谷氨酰胺酶抑制劑 | |
GB201507921D0 (en) | Mapping cytosine modifications | |
ZA201406082B (en) | Use of ccr3-inhibitors | |
EP2866893A4 (en) | HETEROCYCLIC GUANIDINE F1FO ATPASE INHIBITORS | |
HK1211024A1 (en) | Inhibitors of syk syk | |
HK1209422A1 (en) | Fbxo3 inhibitors fbxo3 | |
HK1209105A1 (en) | Vegfr3 inhibitors vegfr3 | |
HK1209104A1 (en) | Vegfr3 inhibitors vegfr3 | |
EP2881113A4 (en) | NEW APPLICATION OF POGOSTONE | |
PL2888228T3 (pl) | Inhibitory oddziaływania CD40-TRAF6 | |
HK1215571A1 (zh) | 二鹽酸科比思特 | |
IL238391A (en) | Rock inhibitors | |
GB2523919B (en) | Mapping cytosine modifications | |
EP2812807A4 (en) | REAL PROPERTY OF SHARED DATA | |
GB201201857D0 (en) | Pseudonymisation/de-pseudonymisation of data | |
GB201217666D0 (en) | Construction of surfaces |