SG10202012428PA - Engineered imine reductases and methods for the reductive amination of ketone and amine compounds - Google Patents

Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Info

Publication number
SG10202012428PA
SG10202012428PA SG10202012428PA SG10202012428PA SG10202012428PA SG 10202012428P A SG10202012428P A SG 10202012428PA SG 10202012428P A SG10202012428P A SG 10202012428PA SG 10202012428P A SG10202012428P A SG 10202012428PA SG 10202012428P A SG10202012428P A SG 10202012428PA
Authority
SG
Singapore
Prior art keywords
ketone
methods
amine compounds
reductive amination
engineered imine
Prior art date
Application number
SG10202012428PA
Other languages
English (en)
Inventor
Oscar Alvizo
Melissa Mayo
Jeffrey Moore
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG10202012428PA publication Critical patent/SG10202012428PA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
SG10202012428PA 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds SG10202012428PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462084037P 2014-11-25 2014-11-25

Publications (1)

Publication Number Publication Date
SG10202012428PA true SG10202012428PA (en) 2021-01-28

Family

ID=56074943

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201703258PA SG11201703258PA (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
SG10202012428PA SG10202012428PA (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201703258PA SG11201703258PA (en) 2014-11-25 2015-11-24 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Country Status (10)

Country Link
US (5) US10370648B2 (zh)
EP (1) EP3224354B1 (zh)
JP (1) JP6719463B2 (zh)
CN (1) CN107002050A (zh)
CA (1) CA2968275C (zh)
DK (1) DK3224354T3 (zh)
HU (1) HUE053363T2 (zh)
IL (1) IL251928B (zh)
SG (2) SG11201703258PA (zh)
WO (1) WO2016085916A1 (zh)

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* Cited by examiner, † Cited by third party
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HUE053363T2 (hu) 2014-11-25 2021-06-28 Codexis Inc Módosított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
EP4223766A3 (en) * 2016-08-26 2023-10-18 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CA3136828A1 (en) * 2019-05-01 2020-11-05 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN110951705B (zh) * 2019-12-20 2020-09-25 中国科学院苏州生物医学工程技术研究所 胺脱氢酶突变体、酶制剂、重组载体、重组细胞及其制备方法和应用
CN112852771B (zh) * 2020-04-17 2022-04-08 中国科学院天津工业生物技术研究所 酶催化合成手性氨基醇化合物
CN112779300B (zh) * 2020-12-15 2022-10-21 上海合全药物研发有限公司 生物催化制备(s)-3-丁炔-2-胺的方法
CN113774036B (zh) * 2021-10-18 2022-10-11 迪嘉药业集团有限公司 一种亚胺还原酶突变体及其应用
CN114717211B (zh) * 2022-03-23 2023-06-02 江苏集萃分子工程研究院有限公司 亚胺还原酶突变体m5及其在合成氮杂环手性胺中的应用
CN114807071B (zh) * 2022-05-11 2023-10-20 中国科学院天津工业生物技术研究所 一种托法替布关键中间体的酶法制备方法

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Also Published As

Publication number Publication date
JP2018500887A (ja) 2018-01-18
CN107002050A (zh) 2017-08-01
JP6719463B2 (ja) 2020-07-15
IL251928A0 (en) 2017-06-29
EP3224354A1 (en) 2017-10-04
WO2016085916A1 (en) 2016-06-02
EP3224354B1 (en) 2021-01-13
US11802274B2 (en) 2023-10-31
EP3224354A4 (en) 2018-05-16
US20220275349A1 (en) 2022-09-01
CA2968275A1 (en) 2016-06-02
SG11201703258PA (en) 2017-05-30
US20240132856A1 (en) 2024-04-25
IL251928B (en) 2019-12-31
US10793836B2 (en) 2020-10-06
DK3224354T3 (da) 2021-03-01
HUE053363T2 (hu) 2021-06-28
CA2968275C (en) 2023-09-12
US10370648B2 (en) 2019-08-06
US11352609B2 (en) 2022-06-07
US20190300865A1 (en) 2019-10-03
US20200399616A1 (en) 2020-12-24
US20170355966A1 (en) 2017-12-14

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