SG10201804788XA - Antibody-drug conjugate - Google Patents
Antibody-drug conjugateInfo
- Publication number
- SG10201804788XA SG10201804788XA SG10201804788XA SG10201804788XA SG10201804788XA SG 10201804788X A SG10201804788X A SG 10201804788XA SG 10201804788X A SG10201804788X A SG 10201804788XA SG 10201804788X A SG10201804788X A SG 10201804788XA SG 10201804788X A SG10201804788X A SG 10201804788XA
- Authority
- SG
- Singapore
- Prior art keywords
- antibody
- drug conjugate
- antitumor
- terminal
- following formula
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title abstract 3
- 229940049595 antibody-drug conjugate Drugs 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
ANTIBODY-DRUG CONJUGATE As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -1, 1 - L 2 -L P -NH-(CH 2 )n l -L a -L'-L c - wherein the antibody is connected to the terminal of L l , and the antitumor compound is connected to the terminal of L with the nitrogen atom of the amino group at position 1 as a connecting position. No Suitable v Figure . rw e
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012225887 | 2012-10-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201804788XA true SG10201804788XA (en) | 2018-07-30 |
Family
ID=50477169
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201502887WA SG11201502887WA (en) | 2012-10-11 | 2013-10-10 | Antibody-drug conjugate |
SG10201804788XA SG10201804788XA (en) | 2012-10-11 | 2013-10-10 | Antibody-drug conjugate |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201502887WA SG11201502887WA (en) | 2012-10-11 | 2013-10-10 | Antibody-drug conjugate |
Country Status (30)
Country | Link |
---|---|
US (5) | US10195288B2 (en) |
EP (3) | EP3632471A1 (en) |
JP (8) | JP5953378B2 (en) |
KR (13) | KR102237639B1 (en) |
CN (4) | CN104755494B (en) |
AU (4) | AU2013328111B2 (en) |
BR (3) | BR112015006521B1 (en) |
CA (2) | CA2885800C (en) |
CY (2) | CY1120363T1 (en) |
DK (2) | DK2907824T3 (en) |
ES (2) | ES2773710T3 (en) |
HK (2) | HK1210477A1 (en) |
HR (2) | HRP20180870T1 (en) |
HU (2) | HUE039000T2 (en) |
IL (5) | IL313147A (en) |
LT (2) | LT2907824T (en) |
MX (3) | MX364484B (en) |
MY (1) | MY170251A (en) |
NZ (4) | NZ740948A (en) |
PH (2) | PH12015500667B1 (en) |
PL (2) | PL3342785T3 (en) |
PT (2) | PT3342785T (en) |
RS (2) | RS57278B1 (en) |
RU (1) | RU2664465C2 (en) |
SG (2) | SG11201502887WA (en) |
SI (2) | SI2907824T1 (en) |
TR (1) | TR201809636T4 (en) |
TW (5) | TWI696611B (en) |
WO (1) | WO2014057687A1 (en) |
ZA (2) | ZA201501825B (en) |
Families Citing this family (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102237639B1 (en) | 2012-10-11 | 2021-04-07 | 다이이찌 산쿄 가부시키가이샤 | Antibody-drug conjugate |
US9872924B2 (en) | 2012-10-19 | 2018-01-23 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
CN116987193A (en) | 2013-12-25 | 2023-11-03 | 第一三共株式会社 | anti-TROP 2 antibody-drug conjugates |
IL278891B2 (en) * | 2014-01-31 | 2024-06-01 | Daiichi Sankyo Co Ltd | Anti-her2 antibody-drug conjugates, compositions comprising same and uses thereof |
JP2017114763A (en) * | 2014-03-26 | 2017-06-29 | 第一三共株式会社 | Anti-CD98 antibody-drug conjugate |
US11185594B2 (en) | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
KR101937549B1 (en) * | 2014-04-10 | 2019-01-10 | 다이이찌 산쿄 가부시키가이샤 | Anti-her3 antibody-drug conjugate |
EP4180455A1 (en) * | 2015-06-29 | 2023-05-17 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
WO2017110923A1 (en) * | 2015-12-24 | 2017-06-29 | 旭硝子株式会社 | Resin composition, substrate, and cell culture method |
KR102514317B1 (en) | 2016-04-15 | 2023-03-27 | 마크로제닉스, 인크. | Novel B7-H3-binding molecules, antibody drug conjugates thereof and methods of use thereof |
SG10201914119TA (en) * | 2016-06-08 | 2020-02-27 | Abbvie Inc | Anti-b7-h3 antibodies and antibody drug conjugates |
WO2017214322A1 (en) * | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
TW201825524A (en) * | 2016-09-20 | 2018-07-16 | 中國大陸商上海藥明生物技術有限公司 | Novel anti-PCSK9 antibody |
SG10201912575RA (en) | 2016-12-12 | 2020-02-27 | Daiichi Sankyo Co Ltd | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
SG11201906554RA (en) * | 2017-01-17 | 2019-08-27 | Daiichi Sankyo Co Ltd | Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate |
JP7181181B2 (en) | 2017-02-28 | 2022-11-30 | 第一三共株式会社 | Method for treating EGFR-TKI-resistant non-small cell lung cancer by administration of anti-HER3 antibody-drug conjugate |
TWI794230B (en) * | 2017-05-15 | 2023-03-01 | 日商第一三共股份有限公司 | Anti cdh6 antibodies and anti cdh6 antibody drug conjugates, as well as manufacturing method thereof |
WO2019024911A1 (en) * | 2017-08-04 | 2019-02-07 | 江苏恒瑞医药股份有限公司 | B7h3 antibody-drug conjugate and medical use thereof |
CN109106951A (en) * | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | A kind of camptothecine-antibody coupling matter |
CN110944667B (en) * | 2017-08-23 | 2024-08-27 | 第一三共株式会社 | Antibody-drug conjugate formulations and lyophilization thereof |
KR20240018674A (en) | 2017-08-31 | 2024-02-13 | 다이이찌 산쿄 가부시키가이샤 | Novel method for producing antibody-drug conjugate |
EP3677589A4 (en) * | 2017-08-31 | 2021-04-21 | Daiichi Sankyo Company, Limited | Improved method for producing antibody-drug conjugate |
AU2018342527B2 (en) | 2017-09-29 | 2024-06-27 | Daiichi Sankyo Company, Limited | Antibody-pyrrolobenzodiazepine derivative conjugate |
WO2019154120A1 (en) * | 2018-02-11 | 2019-08-15 | 四川科伦博泰生物医药股份有限公司 | Cytotoxic agent and conjugate thereof, preparation method therefor and use thereof |
PT3794042T (en) | 2018-05-18 | 2024-06-14 | Daiichi Sankyo Co Ltd | Anti-muc1 antibody-drug conjugate |
CA3103629A1 (en) | 2018-06-15 | 2019-12-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
EP3828206A4 (en) | 2018-07-25 | 2022-04-20 | Daiichi Sankyo Company, Limited | Effective method for manufacturing antibody-drug conjugate |
JP7406488B2 (en) | 2018-07-27 | 2023-12-27 | 第一三共株式会社 | Protein that recognizes the drug site of the antibody-drug conjugate |
US20210290777A1 (en) * | 2018-07-31 | 2021-09-23 | Daiichi Sankyo Company, Limited | Treatment of metastatic brain tumor by administration of antibody-drug conjugate |
BR112021001750A2 (en) * | 2018-08-06 | 2021-04-27 | Daiichi Sankyo Company, Limited | pharmaceutical composition |
CN112739826A (en) | 2018-08-23 | 2021-04-30 | 第一三共株式会社 | Sensitivity markers for antibody-drug conjugates |
KR102567591B1 (en) | 2018-09-06 | 2023-08-16 | 다이이찌 산쿄 가부시키가이샤 | Novel cyclic dinucleotide derivative and antibody-drug conjugate thereof |
JPWO2020059772A1 (en) | 2018-09-20 | 2021-08-30 | 第一三共株式会社 | Treatment of HER3 mutant cancer with anti-HER3 antibody-drug conjugate |
US20210353764A1 (en) * | 2018-09-26 | 2021-11-18 | Jiangsu Hengrui Medicine Co., Ltd. | Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof |
US20210347894A1 (en) * | 2018-09-30 | 2021-11-11 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof |
TW202031298A (en) | 2018-11-14 | 2020-09-01 | 日商第一三共股份有限公司 | Anti-cdh6 antibody-pyrrolobenzodiazepine derivatives conjugate |
CA3122946A1 (en) | 2018-12-11 | 2020-06-18 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with parp inhibitor |
US20220040324A1 (en) * | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
AU2020241896A1 (en) | 2019-03-20 | 2021-09-23 | The Regents Of The University Of California | Claudin-6 antibodies and drug conjugates |
CN114206934A (en) | 2019-03-20 | 2022-03-18 | 加利福尼亚大学董事会 | Encapsulated protein-6 bispecific antibodies |
CN113631196B (en) | 2019-03-29 | 2024-03-15 | 免疫医疗有限公司 | Compounds and conjugates thereof |
WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
CN111689980A (en) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | Camptothecin drug and antibody conjugate thereof |
AU2020301289A1 (en) * | 2019-06-28 | 2022-02-24 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody-drug conjugate, intermediate thereof, preparation method therefor and application thereof |
CN117731798A (en) * | 2019-06-28 | 2024-03-22 | 泰州复旦张江药业有限公司 | Antibody coupling drug, intermediate thereof, preparation method and application |
KR20220052918A (en) | 2019-07-10 | 2022-04-28 | 싸이브렉사 2, 인크. | Peptide conjugates of cytotoxins as therapeutic agents |
EP3996749A1 (en) | 2019-07-10 | 2022-05-18 | Cybrexa 3, Inc. | Peptide conjugates of microtubule-targeting agents as therapeutics |
BR112022004913A2 (en) * | 2019-09-18 | 2022-06-07 | Baili Bio Chengdu Pharmaceutical Co Ltd | Camptothecin derivative and conjugate thereof |
JP2023505708A (en) * | 2019-12-12 | 2023-02-10 | 江蘇恒瑞医薬股▲ふん▼有限公司 | Anti-claudin antibody drug conjugate and pharmaceutical use thereof |
CA3163130A1 (en) * | 2019-12-16 | 2021-06-24 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-cea antibody-exatecan analog conjugate and pharmaceutical use thereof |
EP4076434A1 (en) | 2019-12-17 | 2022-10-26 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
AU2021210079A1 (en) | 2020-01-22 | 2022-08-25 | Jiangsu Hengrui Medicine Co., Ltd. | Drug conjugate of Eribulin derivative, preparation method therefor and application thereof in medicine |
WO2021147993A1 (en) | 2020-01-22 | 2021-07-29 | 江苏恒瑞医药股份有限公司 | Anti-trop-2 antidody-exatecan analog conjugate and medical use thereof |
CA3168882A1 (en) | 2020-02-25 | 2021-09-02 | Mediboston, Inc. | Camptothecin derivatives and conjugates thereof |
KR20220151630A (en) | 2020-03-06 | 2022-11-15 | 다이이찌 산쿄 가부시키가이샤 | Antibody Drug Conjugates Containing Novel Cyclic Dinucleotide Derivatives |
WO2021190480A1 (en) * | 2020-03-24 | 2021-09-30 | 上海翰森生物医药科技有限公司 | Antibody-drug conjugate and medical use thereof |
CA3177279A1 (en) * | 2020-03-25 | 2021-09-30 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-psma antibody-exatecan analogue conjugate and medical use thereof |
CN115103858A (en) | 2020-03-25 | 2022-09-23 | 江苏恒瑞医药股份有限公司 | Preparation method of antibody drug conjugate |
CA3175733A1 (en) | 2020-03-25 | 2021-09-30 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Pharmaceutical composition comprising antibody drug conjugate and use thereof |
CA3173263A1 (en) | 2020-03-30 | 2021-10-07 | Yasuhiro Matsumura | Antibody drug conjugate |
MX2022015695A (en) * | 2020-06-08 | 2023-03-21 | Baili Bio Chengdu Pharmaceutical Co Ltd | Camptothecin drug having high-stability hydrophilic connecting unit and conjugate thereof. |
WO2021260582A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and aurora b inhibitor |
US20230330243A1 (en) | 2020-06-24 | 2023-10-19 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and atr inhibitor |
TW202216209A (en) | 2020-06-24 | 2022-05-01 | 英商阿斯特捷利康英國股份有限公司 | Combination of antibody-drug conjugate and atm inhibitor |
WO2021260583A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and dna-pk inhibitor |
CN116615248A (en) | 2020-06-24 | 2023-08-18 | 阿斯利康(英国)有限公司 | Combination of antibody-drug conjugate and CDK9 inhibitor |
JP2023532339A (en) | 2020-06-29 | 2023-07-27 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | Viruses engineered to promote sanotransmission and their use in treating cancer |
US11423081B1 (en) | 2020-06-30 | 2022-08-23 | Snowflake Inc. | Accessing files in a database stage using a user defined function |
US11361026B2 (en) | 2020-06-30 | 2022-06-14 | Snowflake Inc. | Accessing files in a database stage using a user defined function |
US10997243B1 (en) | 2020-06-30 | 2021-05-04 | Snowflake Inc. | Supporting unstructured, semi-structured, and structured files |
WO2022008419A1 (en) | 2020-07-06 | 2022-01-13 | Byondis B.V. | Antifolate linker-drugs and antibody-drug conjugates |
US20230293712A1 (en) * | 2020-07-10 | 2023-09-21 | VelosBio Inc. | Novel ror1 antibody immunoconjugates |
WO2022015656A1 (en) * | 2020-07-13 | 2022-01-20 | Regeneron Pharmaceuticals, Inc. | Camptothecin analogs conjugated to a glutamine residue in a protein, and their use |
IL299803A (en) | 2020-07-17 | 2023-03-01 | Daiichi Sankyo Co Ltd | Method for producing antibody-drug conjugate |
EP4196500A2 (en) | 2020-08-13 | 2023-06-21 | Innate Pharma | Cancer treatment methods using anti-cd73 antibodies |
EP4183421A1 (en) | 2020-08-13 | 2023-05-24 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Antibody drug conjugate |
JPWO2022050300A1 (en) | 2020-09-02 | 2022-03-10 | ||
WO2022068878A1 (en) | 2020-09-30 | 2022-04-07 | 映恩生物制药(苏州)有限公司 | Antitumor compound, and preparation method therefor and use thereof |
MX2023004047A (en) | 2020-10-09 | 2023-04-27 | Astrazeneca Uk Ltd | Combination of antibody-drug conjugate and parp1 selective inhibitor. |
AU2021359457A1 (en) * | 2020-10-12 | 2023-05-11 | Baili-Bio (Chengdu) Pharmaceutical Co., Ltd. | Camptothecin derivative and its ligand-drug conjugate |
KR20230106645A (en) | 2020-11-11 | 2023-07-13 | 다이이찌 산쿄 가부시키가이샤 | Combination of antibody-drug conjugate with anti-SIRPα antibody |
WO2022099762A1 (en) * | 2020-11-12 | 2022-05-19 | 博瑞生物医药(苏州)股份有限公司 | Antibody conjugate intermediate and preparation method therefor |
US20230398230A1 (en) | 2020-11-12 | 2023-12-14 | Daiichi Sankyo Company, Limited | Treatment of mesothelioma by administration of anti-b7-h3 antibody-drug conjugate |
JP2023550532A (en) * | 2020-12-18 | 2023-12-01 | シャンハイ フダン-チャンジャン バイオ-ファーマシューティカル カンパニー リミテッド | Antibody-drug conjugate targeting TROP2, its production method and use |
JP2023550533A (en) * | 2020-12-18 | 2023-12-01 | シャンハイ フダン-チャンジャン バイオ-ファーマシューティカル カンパニー リミテッド | Antibody-drug conjugate targeting B7-H3, its production method and use |
US20240066138A1 (en) * | 2020-12-23 | 2024-02-29 | Shanghai Ruotuo Biosciences Co., Ltd. | Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications |
TW202245844A (en) * | 2021-01-13 | 2022-12-01 | 紀念斯隆凱特琳癌症中心 | Anti-dll3 antibody-drug conjugate |
CN114805377A (en) * | 2021-01-29 | 2022-07-29 | 明慧医药(杭州)有限公司 | Toxin molecules suitable for antibody-drug conjugates |
TW202241454A (en) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | Novel method for producing antibody-immunostimulator conjugate |
AU2022220512A1 (en) | 2021-02-09 | 2023-07-13 | Medilink Therapeutics (Suzhou) Co., Ltd. | Bioactive substance conjugate, preparation method therefor and use thereof |
CN116917341A (en) | 2021-03-12 | 2023-10-20 | 第一三共株式会社 | Sugar chain and method for producing pharmaceutical product containing sugar chain |
TW202300148A (en) * | 2021-03-17 | 2023-01-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | Preparation method of camptothecin derivatives |
KR20230158005A (en) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | Selective drug release from internalized conjugates of biologically active compounds |
US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
AU2022253902A1 (en) | 2021-04-10 | 2023-11-02 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
WO2022218331A1 (en) * | 2021-04-14 | 2022-10-20 | Genequantum Healthcare (Suzhou) Co., Ltd. | Linkers, conjugates and applications thereof |
EP4079327A1 (en) | 2021-04-22 | 2022-10-26 | Centaurus Polytherapeutics | Payloads for drug-conjugates and their use for treating cancer |
TW202308699A (en) | 2021-04-23 | 2023-03-01 | 美商普方生物製藥美國公司 | Cd70 binding agents, conjugates thereof and methods of using the same |
CN116917324A (en) * | 2021-04-26 | 2023-10-20 | 江苏恒瑞医药股份有限公司 | anti-Nectin-4 antibody and anti-Nectin-4 antibody-drug conjugate and medical application thereof |
CN113816969B (en) * | 2021-04-30 | 2024-01-16 | 联宁(苏州)生物制药有限公司 | Eptification control compound, antibody drug conjugate thereof and application thereof |
US11645243B2 (en) | 2021-06-07 | 2023-05-09 | Snowflake Inc. | Accessing files in a database stage using a user defined function |
EP4357348A1 (en) * | 2021-06-17 | 2024-04-24 | Minghui Pharmaceutical (Hangzhou) Ltd. | Antitumor compound and use thereof |
JP2024524363A (en) | 2021-06-28 | 2024-07-05 | ビョンディス・ビー.ブイ. | Conjugates Containing Phosphoantigens and Uses in Therapy - Patent application |
CA3224374A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
TW202320857A (en) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | Linkers, drug linkers and conjugates thereof and methods of using the same |
CN113402584A (en) * | 2021-07-06 | 2021-09-17 | 联宁(苏州)生物制药有限公司 | Synthetic method of intermediate LND1067-L1 of antibody-coupled drug linker |
CN113527418B (en) * | 2021-07-16 | 2022-05-03 | 成都普康唯新生物科技有限公司 | Preparation method of ADC linker |
IL309884A (en) * | 2021-07-19 | 2024-03-01 | Zeno Man Inc | Immunoconjugates and methods |
US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
AU2022314086A1 (en) | 2021-07-21 | 2024-02-22 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing anti-trop2 antibody drug conjugate and use thereof |
CN118317795A (en) | 2021-09-15 | 2024-07-09 | 第一三共株式会社 | Antibody-drug conjugates for use in methods of treating chemotherapy-resistant cancers |
CA3234692A1 (en) | 2021-09-30 | 2023-04-06 | Ajinomoto Co., Inc. | Conjugate of antibody and functional substance or salt thereof, and antibody derivative and compound used in production of the same or salts thereof |
TW202330041A (en) | 2021-10-18 | 2023-08-01 | 日商第一三共股份有限公司 | Anti-cd37 antibody-drug conjugate |
AU2022386505A1 (en) | 2021-11-15 | 2024-05-23 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
US11814394B2 (en) * | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
IL312875A (en) | 2021-11-18 | 2024-07-01 | Astrazeneca Uk Ltd | Combination of antibody-drug conjugate and parp1 selective inhibitor |
CA3238167A1 (en) | 2021-11-19 | 2023-05-25 | Maria Leia Smith | Gpc3 binding agents, conjugates thereof and methods of using the same |
JPWO2023100829A1 (en) | 2021-11-30 | 2023-06-08 | ||
CN116212044A (en) | 2021-12-03 | 2023-06-06 | 成都百利多特生物药业有限责任公司 | Anti-human Trop2 antibody-camptothecin drug conjugate and medical application thereof |
CA3240378A1 (en) | 2021-12-23 | 2023-06-29 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-dll3 antibody and pharmaceutical use thereof, and antibody-drug conjugate containing anti-dll3 antibody |
WO2023116911A1 (en) * | 2021-12-24 | 2023-06-29 | 百奥泰生物制药股份有限公司 | ANTI-FRα ANTIBODY, AND ANTIBODY-DRUG CONJUGATE AND USE THEREOF |
WO2023126822A1 (en) | 2021-12-28 | 2023-07-06 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and rasg12c inhibitor |
TW202339805A (en) | 2021-12-28 | 2023-10-16 | 英商阿斯特捷利康英國股份有限公司 | Combination of antibody-drug conjugate and atr inhibitor |
WO2023126297A1 (en) | 2021-12-30 | 2023-07-06 | Byondis B.V. | Antifolate linker-drugs and antibody-drug conjugates |
WO2023138635A1 (en) * | 2022-01-18 | 2023-07-27 | 甘李药业股份有限公司 | Exatecan derivative-antibody conjugate and medical use thereof |
WO2023143263A1 (en) | 2022-01-25 | 2023-08-03 | 苏州宜联生物医药有限公司 | Antibody against her3, conjugate and use thereof |
WO2023173026A1 (en) | 2022-03-10 | 2023-09-14 | Sorrento Therapeutics, Inc. | Antibody-drug conjugates and uses thereof |
WO2023175483A1 (en) | 2022-03-16 | 2023-09-21 | Astrazeneca Uk Limited | A scoring method for an anti-trop2 antibody‑drug conjugate therapy |
WO2023209591A1 (en) | 2022-04-27 | 2023-11-02 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
TW202400650A (en) | 2022-05-11 | 2024-01-01 | 日商第一三共股份有限公司 | Combination of an antibody and cd47 inhibitor |
WO2023228095A1 (en) | 2022-05-24 | 2023-11-30 | Daiichi Sankyo Company, Limited | Dosage regimen of an anti-cdh6 antibody-drug conjugate |
WO2023237050A1 (en) * | 2022-06-09 | 2023-12-14 | Beigene, Ltd. | Antibody drug conjugates |
CN116789733A (en) * | 2022-07-05 | 2023-09-22 | 上海药明合联生物技术有限公司 | Coupling linker |
CN115160403A (en) * | 2022-07-05 | 2022-10-11 | 上海彩迩文生化科技有限公司 | Specific topoisomerase inhibitor and conjugate used for antibody drug and preparation method thereof |
CN118251241A (en) | 2022-07-15 | 2024-06-25 | 启德医药科技(苏州)有限公司 | Antibodies, linkers, supports, conjugates and uses thereof |
WO2024020536A1 (en) * | 2022-07-22 | 2024-01-25 | Nj Bio, Inc. | Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells |
WO2024022372A1 (en) * | 2022-07-27 | 2024-02-01 | 明慧医药(杭州)有限公司 | Antibody-drug conjugate and use thereof |
CN117510515A (en) * | 2022-07-28 | 2024-02-06 | 明慧医药(杭州)有限公司 | Toxin molecules suitable for antibody-drug conjugates |
WO2024023750A1 (en) | 2022-07-28 | 2024-02-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and bispecific checkpoint inhibitor |
WO2024049931A1 (en) | 2022-09-02 | 2024-03-07 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
WO2024073436A2 (en) * | 2022-09-26 | 2024-04-04 | Solve Therapeutics, Inc. | Compositions and uses thereof |
WO2024067811A1 (en) * | 2022-09-30 | 2024-04-04 | Beigene, Ltd. | Ligand-drug conjugate of exatecan analogue, and medical use thereof |
US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
WO2024091437A1 (en) | 2022-10-25 | 2024-05-02 | Merck Sharp & Dohme Llc | Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof |
WO2024110905A1 (en) | 2022-11-24 | 2024-05-30 | Beigene, Ltd. | Anti-cea antibody drug conjugates and methods of use |
WO2024109949A1 (en) * | 2022-11-25 | 2024-05-30 | 明慧医药(杭州)有限公司 | Anti-tumor compound and use thereof |
CN118105508A (en) * | 2022-11-29 | 2024-05-31 | 四川科伦博泰生物医药股份有限公司 | Medicinal linker compound, preparation method and application thereof |
WO2024116094A1 (en) | 2022-11-30 | 2024-06-06 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugates and dnmt inhibitors |
US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
CN116621927B (en) * | 2023-01-09 | 2024-03-26 | 联宁(苏州)生物制药有限公司 | Antibody coupling intermediate with irinotecan and C-lock fixed-point coupling group, coupling method and antibody coupling drug |
WO2024165045A1 (en) | 2023-02-09 | 2024-08-15 | Beigene, Ltd. | Self-stabilizing linker conjugates |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
JP3008226B2 (en) | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | Hexacyclic compounds |
US5637770A (en) * | 1991-01-16 | 1997-06-10 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
JPH0559061U (en) | 1991-04-18 | 1993-08-03 | 株式会社ケイヴイシー | Ball valve |
JP3540315B2 (en) | 1991-09-23 | 2004-07-07 | メディカル リサーチ カウンシル | Production of Chimeric Antibodies-Combination Approach |
DE69233745D1 (en) | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Preparation of Autoantibodies on Phage Surfaces Starting from Antibody Segment Libraries |
CA2131151A1 (en) | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
JP3359955B2 (en) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | Antitumor agent |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
JPH0687746U (en) | 1993-06-02 | 1994-12-22 | 株式会社ユニシアジェックス | Hydraulic buffer reservoir tube structure |
GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
WO1995015388A1 (en) | 1993-12-03 | 1995-06-08 | Medical Research Council | Recombinant binding proteins and peptides |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
JPH08337584A (en) | 1995-04-10 | 1996-12-24 | Dai Ichi Seiyaku Co Ltd | Condensed six-membered cyclic amino compound, medicine containing the same and production of the same |
SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
JPH1095802A (en) | 1995-12-28 | 1998-04-14 | Tanabe Seiyaku Co Ltd | Camptothecine derivative |
CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
JPH1171280A (en) | 1997-06-26 | 1999-03-16 | Tanabe Seiyaku Co Ltd | Medicine composition |
JPH1192405A (en) * | 1997-09-19 | 1999-04-06 | Dai Ichi Seiyaku Co Ltd | Medicinal complex |
PT2180007E (en) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US6835807B1 (en) * | 1998-05-22 | 2004-12-28 | Daiichi Pharmaceuticals Co., Ltd. | Drug complex and drug delivery system |
CN1661044A (en) | 1998-10-30 | 2005-08-31 | 第一制药株式会社 | DDS compound and method for measurement thereof |
EP2270147B2 (en) | 1999-04-09 | 2020-07-22 | Kyowa Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
JP2002060351A (en) | 2000-03-22 | 2002-02-26 | Dai Ichi Seiyaku Co Ltd | Dds compound comprising drug having hydroxy group |
CA2412582A1 (en) | 2000-06-29 | 2002-01-03 | Daiichi Pharmaceutical Co., Ltd. | Dds compound and process for the preparation thereof |
AU2001271037A1 (en) | 2000-07-13 | 2002-01-30 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compounds |
ES2620359T3 (en) | 2000-10-06 | 2017-06-28 | Kyowa Hakko Kirin Co., Ltd. | Cells that produce antibody compositions |
US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
HU230378B1 (en) | 2001-11-01 | 2016-03-29 | Uab Research Foundation | Combinations of anti-dr5 antibodies and anti-dr4 antibodies and other therapeutic agents |
AU2002363939A1 (en) | 2001-11-20 | 2003-06-10 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
JP4959136B2 (en) | 2002-12-13 | 2012-06-20 | イミューノメディクス、インコーポレイテッド | Immunoconjugates with cleavable linkages in cells |
US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
AU2005216978A1 (en) | 2004-02-26 | 2005-09-09 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
EP1725586B1 (en) | 2004-03-02 | 2015-01-14 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
EP1747021B1 (en) * | 2004-05-19 | 2015-09-09 | E. R. Squibb & Sons, L.L.C. | Self-immolative linkers and drug conjugates |
CA2567520A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Maytansinoid-antibody conjugates |
EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
DE102005009099A1 (en) | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | New camptothecin-peptide derivatives, useful for treating cancer |
DE102005009084A1 (en) | 2005-02-28 | 2006-08-31 | Ktb Tumorforschungsgesellschaft Mbh | New anthracyclin-peptide derivatives, useful for treating cancer, especially of the prostate, are cleaved, in the tumor, by prostate-specific antigen to release active antitumor agent and are transported by serum albumen |
US8067546B2 (en) | 2005-04-19 | 2011-11-29 | Seattle Genetics, Inc. | Humanized anti-CD70 binding agents and uses thereof |
US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
ZA200809776B (en) * | 2006-05-30 | 2010-03-31 | Genentech Inc | Antibodies and immunoconjugates and uses therefor |
CN103030696B (en) | 2006-05-30 | 2016-09-28 | 健泰科生物技术公司 | Antibody and immune conjugate and application thereof |
WO2007145306A1 (en) | 2006-06-15 | 2007-12-21 | National University Corporation Hokkaido University | Element having long blood-circulating time which is degradable selectively in tumor tissue |
ITMI20061473A1 (en) | 2006-07-26 | 2008-01-27 | Indena Spa | DERIVATIVES OF CAMPTOTECIN WITH ANTITUMORAL ACTIVITY |
CN101687838A (en) | 2006-12-21 | 2010-03-31 | 先灵公司 | Suppress the active pyrrolo-of KSP kinesin [3,2-A] pyridine derivate |
CN101687021B (en) * | 2007-03-22 | 2013-04-17 | 斯隆-凯特琳癌症研究院 | Uses of monoclonal antibody 8H9 |
KR101892411B1 (en) | 2008-04-30 | 2018-08-27 | 이뮤노젠 아이엔씨 | Cross-linkers and their uses |
EP3903829B1 (en) | 2009-02-13 | 2023-05-03 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
JP5829520B2 (en) | 2009-08-20 | 2015-12-09 | 国立大学法人 千葉大学 | Colchicine derivatives |
WO2011038159A2 (en) | 2009-09-24 | 2011-03-31 | Seattle Genetics, Inc. | Dr5 ligand drug conjugates |
WO2011143209A1 (en) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
WO2011146638A1 (en) | 2010-05-18 | 2011-11-24 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
CA2804185C (en) | 2010-07-12 | 2017-03-21 | Covx Technologies Ireland Limited | Multifunctional antibody conjugates |
CN103313990B (en) | 2010-11-17 | 2016-07-20 | 基因泰克公司 | Alanyl maytansinol antibody coupling matter |
BR112014014763A8 (en) | 2011-12-14 | 2017-07-04 | Seattle Genetics Inc | new antibody-drug conjugates (adcs) and their use |
US20130280282A1 (en) | 2012-04-24 | 2013-10-24 | Daiichi Sankyo Co., Ltd. | Dr5 ligand drug conjugates |
CA2876706A1 (en) | 2012-06-14 | 2013-12-19 | Ambrx, Inc. | Anti-psma antibodies conjugated to nuclear receptor ligand polypeptides |
US9517522B2 (en) * | 2012-09-05 | 2016-12-13 | Illinois Tool Works Inc. | Self-aligning wire feeder assembly |
KR102237639B1 (en) * | 2012-10-11 | 2021-04-07 | 다이이찌 산쿄 가부시키가이샤 | Antibody-drug conjugate |
US9872924B2 (en) * | 2012-10-19 | 2018-01-23 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
US9814784B2 (en) | 2013-01-03 | 2017-11-14 | Celltrion, Inc. | Antibody-linker-drug conjugate, preparation method therefor, and anticancer drug composition containing same |
CN103313390B (en) | 2013-07-05 | 2016-01-20 | 江苏大学 | A kind of WSN localization method based on double-movement beacon |
IL278891B2 (en) * | 2014-01-31 | 2024-06-01 | Daiichi Sankyo Co Ltd | Anti-her2 antibody-drug conjugates, compositions comprising same and uses thereof |
US11185594B2 (en) | 2014-04-10 | 2021-11-30 | Daiichi Sankyo Company, Limited | (Anti-HER2 antibody)-drug conjugate |
US20190386950A1 (en) | 2017-02-24 | 2019-12-19 | Gil Hoon Chang | Message sharing system and method for interactive application |
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