SG10201508047SA - Device for high throughput investigations of cellular interactions - Google Patents

Device for high throughput investigations of cellular interactions

Info

Publication number
SG10201508047SA
SG10201508047SA SG10201508047SA SG10201508047SA SG10201508047SA SG 10201508047S A SG10201508047S A SG 10201508047SA SG 10201508047S A SG10201508047S A SG 10201508047SA SG 10201508047S A SG10201508047S A SG 10201508047SA SG 10201508047S A SG10201508047S A SG 10201508047SA
Authority
SG
Singapore
Prior art keywords
high throughput
cellular interactions
investigations
throughput investigations
interactions
Prior art date
Application number
SG10201508047SA
Inventor
Roger Dale Kamm
Haruhiko Harry Asada
Waleed Ahmed Farahat
Loannis K Zervantonakis
Levi B Wood
Chandrasekhar Kothapalli
Seok Chung
Jeffrey D Macklis
Suzanne Tharin
Johanna Varner
Young Kum Park
Kwang Ho Lee
Nguyen Le Thanh Tu
Choong Kim
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of SG10201508047SA publication Critical patent/SG10201508047SA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5064—Endothelial cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
SG10201508047SA 2010-09-29 2011-09-29 Device for high throughput investigations of cellular interactions SG10201508047SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38767410P 2010-09-29 2010-09-29
US39462410P 2010-10-19 2010-10-19

Publications (1)

Publication Number Publication Date
SG10201508047SA true SG10201508047SA (en) 2015-10-29

Family

ID=45938655

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013023411A SG189160A1 (en) 2010-09-29 2011-09-29 Device for high throughput investigations of cellular interactions
SG10201508047SA SG10201508047SA (en) 2010-09-29 2011-09-29 Device for high throughput investigations of cellular interactions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013023411A SG189160A1 (en) 2010-09-29 2011-09-29 Device for high throughput investigations of cellular interactions

Country Status (8)

Country Link
US (1) US9261496B2 (en)
EP (1) EP2622342A4 (en)
JP (1) JP6170431B2 (en)
KR (1) KR101720378B1 (en)
CN (1) CN103477222B (en)
CA (1) CA2813211C (en)
SG (2) SG189160A1 (en)
WO (1) WO2012050981A1 (en)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
US9206384B2 (en) 2011-12-03 2015-12-08 Emd Millipore Corporation Micro-incubation systems for microfluidic cell culture and methods
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
EP2245453B1 (en) 2008-01-03 2016-10-05 EMD Millipore Corporation Microfluidic cell culture array system for automated assays and methods of operation
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
KR101322798B1 (en) 2011-10-28 2013-10-29 고려대학교 산학협력단 Cell culture assay
CN102728422B (en) * 2012-06-11 2015-02-18 清华大学 Microfluidic chip apparatus and application thereof
US9518977B2 (en) 2012-10-19 2016-12-13 University Of Washington Through Its Center For Commercialization Microfluidic assay apparatus and methods of use
US20140127733A1 (en) 2012-11-01 2014-05-08 Moffit Cancer Center Ex vivo microfluidic analysis of biologic samples
EP2741083B1 (en) * 2012-12-07 2015-06-17 Devrim Pesen Okvur Three dimensional microfluidic device that determines metastatic capacity and homing choices
EP2965082B1 (en) * 2013-03-05 2016-12-28 F. Hoffmann-La Roche AG Method and system for determining a biological response of a target to a soluble candidate substance
US20140255970A1 (en) * 2013-03-08 2014-09-11 Cfd Research Corporation Synthetic microfluidic systems for hypoxia
US9580678B2 (en) * 2013-06-21 2017-02-28 The Regents Of The University Of California Microfluidic tumor tissue dissociation device
EP2818244A1 (en) * 2013-06-27 2014-12-31 Ospedale San Raffaele S.r.l. Flow chamber and uses thereof
US10487349B2 (en) 2013-07-10 2019-11-26 Gradientech Ab Use of a fluidic device
EP3027730A4 (en) * 2013-07-29 2016-08-31 9493662 Canada Inc Microfluidic cell culture systems
JP6151128B2 (en) * 2013-08-12 2017-06-21 株式会社東芝 Semiconductor micro-analysis chip and manufacturing method thereof
US9815059B2 (en) 2013-10-07 2017-11-14 Devrim PESEN OKVUR Microfluidic device for investigation of distance dependent interactions in cell biology
KR101714823B1 (en) * 2013-10-10 2017-03-09 재단법인대구경북과학기술원 Monitering and control system for cultivating cell in sample using microfluidic channel device
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
EP3783094B1 (en) 2013-10-22 2023-10-11 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
CN103756903A (en) * 2014-01-10 2014-04-30 赵海涛 Three-dimensional culture system for screening liver-caner chemotherapeutic drugs
CN103756904A (en) * 2014-01-10 2014-04-30 赵海涛 Three-dimensional culture system for tumor cell culture
KR101644635B1 (en) * 2014-05-30 2016-08-03 서울대학교산학협력단 Microfluidic chip for generating microvessel and a method for analyzing cancer metastasis using thereof
CN106471122B (en) 2014-07-07 2020-07-03 阿斯特瑞格诊断公司 Phenotypic identification and in situ genotyping of libraries of genetically distinct cells
CN104130943B (en) * 2014-07-28 2016-06-29 民航总医院 Neuron and the orderly co-culture device of neurogliocyte, preparation method and neuron and the orderly co-culture method of neurogliocyte
GB201415804D0 (en) 2014-09-08 2014-10-22 Univ Singapore Assay Device
US11060067B2 (en) * 2014-09-30 2021-07-13 D. Lansing Taylor Human liver microphysiology platform and self assembly liver acinus model and methods of their use
US10017724B2 (en) * 2014-10-01 2018-07-10 Arizona Board Of Regents On Behalf Of Arizona State University Engineering of a novel breast tumor microenvironment on a microfluidic chip
US10712339B2 (en) 2014-10-01 2020-07-14 Arizona Board Of Regents On Behalf Of Arizona State University Engineering of a novel breast tumor microenvironment on a microfluidic chip
CN107109331A (en) * 2014-10-16 2017-08-29 昆塔麦特利斯株式会社 Single celled novel bioactive test structure is tracked using gelling agent
CN104328040B (en) * 2014-10-31 2016-04-27 青岛大学附属医院 A kind of tumour chemotherapy drug susceptibility detection chip and using method
WO2016076795A1 (en) * 2014-11-11 2016-05-19 Aim Biotech Pte. Ltd. Microfluidic platform for investigating cell-based interactions
CN105713835B (en) * 2014-12-05 2018-11-09 中国科学院大连化学物理研究所 A kind of multi-functional region cell three-dimensional co-culture method based on micro-fluidic chip
KR101659670B1 (en) * 2014-12-29 2016-09-23 한국기초과학지원연구원 A 3-dimensional cell culture-chip for imaging
US10472599B2 (en) 2015-01-07 2019-11-12 Dana-Farber Cancer Institute, Inc. Microfluidic cell culture of patient-derived tumor cell spheroids
CN104630059B (en) * 2015-01-16 2017-07-25 中国科学院深圳先进技术研究院 Micro-fluidic chip and method for setting up co-culture model outside three cell-like cells
CN104549587B (en) * 2015-01-20 2016-02-03 重庆科技学院 A kind of triple channel microballoon screening chip and using method
WO2016132182A1 (en) * 2015-02-20 2016-08-25 Cells For Cells Devices for studying chemotaxis/adherence in cells wherein gradients and channels are formed using hydrogels
KR20230078838A (en) 2015-04-22 2023-06-02 버클리 라잇츠, 인크. Microfluidic cell culture
SG10201909926WA (en) * 2015-04-23 2019-11-28 Univ Singapore Technology & Design Device and method for analysing and controlling cell motility
NL2014840B1 (en) * 2015-05-21 2017-01-31 Intecrypt B V Microfluidic device for in vitro 3D cell culture experimentation.
EP3304085B1 (en) * 2015-05-27 2021-06-23 Cannabics Pharmaceuticals Inc System and method for high throughput screening of cancer cells
US11156595B2 (en) * 2015-05-28 2021-10-26 Axogen Corporation Organotypic DRG-peripheral nerve culture system
WO2017035119A1 (en) * 2015-08-24 2017-03-02 National University Of Singapore Blood brain barrier model in a 3d co-culture microfluidic system
WO2017049237A1 (en) * 2015-09-18 2017-03-23 The General Hospital Corporation Dba Massachusetts General Hospital Personalized approach to dosage of anti-fugetactic agent for treatment of cancer
CN106566863B (en) * 2015-10-10 2020-11-20 中国科学院大连化学物理研究所 Cell bidirectional invasion monitoring method based on micro-fluidic chip
US11180724B2 (en) * 2015-10-23 2021-11-23 The Regents Of The University Of California Microfluidic pressure regulator for robust hydrogel loading without bursting
CN106609242B (en) * 2015-10-26 2020-01-21 泰陞国际科技股份有限公司 Cell bearing device and cell culture system
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
WO2017075297A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. High-throughput dynamic reagent delivery system
CN115532189A (en) * 2015-11-23 2022-12-30 伯克利之光生命科技公司 In-situ generated microfluidic isolation structure, kit and use method thereof
SG11201804699WA (en) 2015-12-04 2018-07-30 Emulate Inc Open-top microfluidic device with structural anchors
TWI758265B (en) 2015-12-08 2022-03-21 美商伯克利之光生命科技公司 In situ-generated microfluidic assay structures, related kits, and methods of use thereof
KR20170074503A (en) * 2015-12-22 2017-06-30 고려대학교 산학협력단 Drug test method for using cell culture assay
US10722540B1 (en) 2016-02-01 2020-07-28 The Regents Of The University Of California Microfluidic device and method for shear stress-induced transformation of cells
SG11201808524QA (en) * 2016-03-30 2018-10-30 Emulate Inc Devices, systems and methods for inhibiting invasion and metastases of cancer
CN109689213B (en) 2016-05-26 2022-10-14 伯克利之光生命科技公司 Covalently modified surface, kit, preparation method and application
GB201609764D0 (en) * 2016-06-03 2016-07-20 Isis Innovation 3D printing of gel networks
US10767149B2 (en) 2016-06-13 2020-09-08 Massachusetts Institute Of Technology Microfluidic device for three dimensional and compartmentalized coculture of neuronal and muscle cells, with functional force readout
CN105854966B (en) * 2016-06-14 2018-01-02 东华大学 A kind of micro-fluidic chip for embedding functionalized nano-fiber film and its application
BR112018075920A2 (en) 2016-06-15 2019-03-26 Mimetas B.V. device and cell culture methods
GB2567529B (en) * 2016-07-12 2021-03-31 Emulate Inc Additive channels
WO2018026784A1 (en) * 2016-08-01 2018-02-08 University Of Georgia Research Foundation, Inc. In situ cell delivery using reconstituted photopolymerized chondroitin sulfate glycosaminoglycan hydrogel matrices
CA3044605A1 (en) * 2016-11-22 2018-05-31 Nutech Ventures Personalized cellular biomanufacturing with a closed, miniature cell culture system
KR101949612B1 (en) * 2016-11-29 2019-02-19 고려대학교 산학협력단 The microfluidic device
CN106544271A (en) * 2016-12-07 2017-03-29 清华大学深圳研究生院 A kind of many cells 3D co-culture devices and method of research tumor invasion blood vessel
KR101848201B1 (en) * 2017-01-04 2018-05-24 고려대학교 산학협력단 Reaction research chip for research of reaction between different kind of cells which compose tissue
EP3351926A1 (en) * 2017-01-18 2018-07-25 Hifibio Method for analyzing and selecting a specific droplet among a plurality of droplets and associated apparatus
WO2018147032A1 (en) 2017-02-09 2018-08-16 公立大学法人大阪府立大学 Fluidic chip for cell culture use, culture vessel, and culture method
JP7284095B2 (en) 2017-03-31 2023-05-30 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド A method for evaluating tumor cell spheroids using a 3D microfluidic cell culture device
WO2018187181A1 (en) 2017-04-03 2018-10-11 The Charles Stark Draper Laboratory, Inc. Microfluidic system for evaluation of chemotherapeutic and immunotherapeutic drugs
WO2018237132A1 (en) * 2017-06-21 2018-12-27 Board Of Regents, The University Of Texas System Vascularized microfluidic platforms
KR101985311B1 (en) * 2017-07-26 2019-06-03 강원대학교산학협력단 3 Dimensional Cell Culture Microchip Containing Nano-porous Membrane And Manufacturing Method Thereof
CN109385373B (en) * 2017-08-11 2022-01-18 复旦大学 Microfluid co-culture device for detecting tumor drug sensitivity and metastasis tendency
US10926257B2 (en) 2017-08-28 2021-02-23 The Regents Of The University Of California Microfluidic device for the digestion of tissues into cellular suspensions
EP3684915A4 (en) * 2017-09-19 2021-06-30 Cornell University Fabrication of a biomimetic platform system and methods of use
US11499128B2 (en) * 2017-09-22 2022-11-15 The Regents Of The University Of Colorado Organ-on-chip microphysiological system
KR102049556B1 (en) * 2018-01-30 2019-11-27 서강대학교 산학협력단 Microfluidic device for studying shear stress and tumor migration in microchannel and method of analyzing cells using the microfluidic device
EP3749453A4 (en) * 2018-02-07 2021-12-15 The Trustees of the University of Pennsylvania High throughput microfluidic device
US11679546B2 (en) 2018-02-09 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate Bioprinter and methods of manufacturing an organomimetic device
WO2019159149A1 (en) * 2018-02-19 2019-08-22 National Research Council Of Canada A microfluidic device for culturing cells comprising a biowall, a bead bed and a biointerface and methods of modelling said biointerface thereof
WO2019178073A1 (en) * 2018-03-12 2019-09-19 North Carolina State University Vascular development monitoring systems and uses thereof
US11207679B2 (en) * 2018-04-13 2021-12-28 Regents Of The University Of Minnesota DNA extraction device
US11480560B2 (en) 2018-06-11 2022-10-25 The Regents Of The University Of Colorado, A Body Corporate Delivery of aerosolized respiratory pathogens
CN109266716A (en) * 2018-09-13 2019-01-25 佛山科学技术学院 A method of detection cell migration quantity
CN109797089B (en) * 2018-09-26 2020-06-26 京东方科技集团股份有限公司 Screening system and method, chip and manufacturing method and system thereof
US20210371786A1 (en) * 2018-10-03 2021-12-02 Oregon Health & Science University Microfluidic devices for dental applications
WO2020081288A1 (en) * 2018-10-14 2020-04-23 Arizona Board Of Regents On Behalf Of Arizona State University Microfluidic devices and methods incorporating organized three-dimensional tissue constructs
JP7388724B2 (en) 2018-10-29 2023-11-29 国立大学法人 東京大学 Artificial multilayer tissue culture device and method for producing artificial multilayer tissue
CN109554346A (en) * 2018-12-05 2019-04-02 首都医科大学附属北京胸科医院 A kind of lung cancer organoid model and its application in tumor research
US11198842B1 (en) * 2019-02-22 2021-12-14 University Of South Florida Microfluidic-coupled in vitro model of the blood-brain barrier
WO2020210296A1 (en) * 2019-04-08 2020-10-15 University Of Georgia Research Foundation, Inc. Flow-based microfluidic platform promoting endothelialization
CN110029059B (en) * 2019-04-22 2022-04-01 清华大学深圳研究生院 Cell co-culture system based on nanofiber membrane
GB201908841D0 (en) * 2019-06-20 2019-08-07 Carinotech Ltd Culture device
CN110295111A (en) * 2019-07-15 2019-10-01 清华大学深圳研究生院 A kind of device of bionical blood vessel network tumor-cell extravasation migration
US20210039089A1 (en) * 2019-08-06 2021-02-11 University Of Georgia Research Foundation, Inc. Devices, kits, and methods for label-free separation and subtyping of rare cells
KR102281857B1 (en) * 2019-08-22 2021-07-28 차의과학대학교 산학협력단 Endomysium scaled heart on a chip for drug efficacy and toxicity test
CN110551681B (en) * 2019-09-12 2021-08-24 清华大学 Micro-fluidic chip for simulating embryo implantation angiogenesis and preparation method and application thereof
KR102157266B1 (en) * 2019-11-22 2020-09-18 차의과학대학교 산학협력단 Perimysium-scaled heart on a chip and uses thereof
EP3838405A1 (en) * 2019-12-20 2021-06-23 Imec VZW A microfluidic device
US20230137145A1 (en) * 2020-04-09 2023-05-04 River Biomedics B.V. Microfluidic device for a 3d tissue structure
KR20230004683A (en) * 2020-04-22 2023-01-06 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 Microfluidic chip and microphysiological system using the same
EP3907275A1 (en) 2020-05-08 2021-11-10 Technische Universität Wien Microfluidic device
CN111849770B (en) * 2020-07-31 2023-07-18 深圳市博塔生物科技有限公司 Method for establishing in-vitro neural network, in-vitro neural network and application of in-vitro neural network
KR102458206B1 (en) * 2020-09-28 2022-10-24 한양대학교 산학협력단 Concentration gradient generator
US11879118B2 (en) * 2020-11-10 2024-01-23 C.C. Imex Gel tray for bacteria transformation lab
WO2022187632A1 (en) * 2021-03-05 2022-09-09 Advanced Solutions Life Sciences, Llc Models and methods to establish perfused vascularized tissues in three-dimensional in vitro culture
USD1016323S1 (en) 2021-04-09 2024-02-27 Ananda Devices Inc. Microfluidic slab
USD1004129S1 (en) 2021-04-09 2023-11-07 Ananda Devices Inc. Microfluidic slab
WO2022226521A1 (en) * 2021-04-21 2022-10-27 Regents Of The University Of Minnesota Three-dimensional microfluidic metastasis array
WO2022226405A1 (en) * 2021-04-23 2022-10-27 Massachusetts Institute Of Technology Fluidic platforms for perfusable vascularized tissues
WO2022272312A1 (en) * 2021-06-25 2022-12-29 Virginia Tech Intellectual Properties Inc. Nanofiber networks as membrane mimics for in vitro applications
WO2023283363A1 (en) * 2021-07-08 2023-01-12 The Texas A&M University System Microfluidic device mimicking tumor microenvironment
WO2023009327A1 (en) 2021-07-28 2023-02-02 California Northstate College Of Pharmacy, Llc Multilayer microfluidics systems and methods
IT202100025460A1 (en) 2021-10-07 2023-04-07 Univ Degli Studi Di Roma “Tor Vergata” LAB-ON-CHIP DEVICE TO STUDY CELLULAR MIGRATION IN THREE-DIMENSIONAL SYSTEMS AND RELATED METHOD OF USE
WO2023073178A1 (en) 2021-10-29 2023-05-04 Universität Bern Microfluidic cell culturing device
CN114231397B (en) * 2021-12-21 2024-02-23 中国医科大学 Centrifugal microfluidic system for high-flux drug testing and application method thereof
KR20230116524A (en) * 2022-01-28 2023-08-04 고려대학교 산학협력단 Apparatus for brain neural modeling
WO2023145208A1 (en) * 2022-01-31 2023-08-03 株式会社エンプラス Fluid handling device, method for manufacturing same, and method for introducing flowable medium to fluid handling device
EP4289933A1 (en) * 2022-06-07 2023-12-13 ibidi GmbH Cell culture substrate

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060199260A1 (en) * 2002-05-01 2006-09-07 Zhiyu Zhang Microbioreactor for continuous cell culture
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
JP2007508815A (en) 2003-10-10 2007-04-12 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド In vitro development of tissues and organs
US7907769B2 (en) 2004-05-13 2011-03-15 The Charles Stark Draper Laboratory, Inc. Image-based methods for measuring global nuclear patterns as epigenetic markers of cell differentiation
CA2586400A1 (en) 2004-11-11 2006-05-18 Agency For Science, Technology And Research Cell culture device
US20070269476A1 (en) 2006-05-16 2007-11-22 Voytik-Harbin Sherry L Engineered extracellular matrices control stem cell behavior
WO2008079320A1 (en) 2006-12-22 2008-07-03 The Regents Of The University Of California Microfluidic platform for cell culture and assay
EP2170419A1 (en) 2007-07-18 2010-04-07 Board Of Trustees Of The University Of Illinois Temporal release of growth factors from 3d micro rod scaffolds for tissue regeneration
CN101376908B (en) * 2007-08-29 2012-01-25 中国科学院大连化学物理研究所 Method for studying medicament metabolism based on molecule and cell level
CN101158694B (en) * 2007-09-21 2011-11-16 中国科学院上海微系统与信息技术研究所 Preparation method of integrated microporous film microflow control chip
EP2203548A4 (en) 2007-10-11 2014-01-15 Agency Science Tech & Res Forming cell structure with transient linker in cage
EP2245453B1 (en) * 2008-01-03 2016-10-05 EMD Millipore Corporation Microfluidic cell culture array system for automated assays and methods of operation
US9121847B2 (en) * 2008-04-08 2015-09-01 Massachussetts Institute Of Technology Three-dimensional microfluidic platforms and methods of use thereof
WO2010009307A2 (en) 2008-07-16 2010-01-21 Children's Medical Center Corporation Organ mimic device with microchannels and methods of use and manufacturing thereof
US9029149B2 (en) 2008-07-31 2015-05-12 Carnegie Mellon University Methods, apparatus, and systems for fabrication of polymeric nano- and micro-fibers in aligned configurations
US9115340B2 (en) 2008-08-08 2015-08-25 Agency For Science Technology & Research Microfluidic continuous flow device
CN102227637A (en) 2008-09-26 2011-10-26 通用医疗公司 Capturing particles
WO2010101708A2 (en) 2009-03-04 2010-09-10 University Of Maine System Board Of Trustees Microfluidic device and related methods
EP2422003A4 (en) 2009-04-24 2012-10-31 Univ Ohio State Interactive microenvironment system
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof

Also Published As

Publication number Publication date
EP2622342A4 (en) 2016-12-14
EP2622342A1 (en) 2013-08-07
SG189160A1 (en) 2013-05-31
CN103477222A (en) 2013-12-25
KR20130131326A (en) 2013-12-03
KR101720378B1 (en) 2017-03-28
CN103477222B (en) 2016-08-10
US20140057311A1 (en) 2014-02-27
JP6170431B2 (en) 2017-07-26
CA2813211C (en) 2017-10-24
WO2012050981A1 (en) 2012-04-19
CA2813211A1 (en) 2012-04-19
JP2013538582A (en) 2013-10-17
US9261496B2 (en) 2016-02-16

Similar Documents

Publication Publication Date Title
SG10201508047SA (en) Device for high throughput investigations of cellular interactions
IL269270A (en) Method and compositions for cellular immunotherapy
ZA201901167B (en) Method and compositions for cellular immunotherapy
ZA201304618B (en) Actuation of an intercepting apparatus
EP2677539A4 (en) Semiconductor device and process for manufacture thereof
EP2737047A4 (en) Methods and devices for electrical sample preparation
EP2816340A4 (en) Headspace sample introduction device
EP2608916A4 (en) Mobile tree-trimming apparatus
SG10201505702UA (en) Switched application processor apparatus for cellular devices
IL249507A0 (en) Use of an anti-il-1a antibody for treating uveitis
HK1188984A1 (en) Methods and devices for using isoperillyl alcohol
EP2652964A4 (en) Multi-wired antenna for mobile apparatus
GB201311447D0 (en) High throughput microfluidic device
TWM389448U (en) Structure for airbag-squeezing device
GB201110521D0 (en) Antenna apparatus
IL231224A0 (en) Antenna apparatus
GB201420134D0 (en) High fidelity restriction endonucleses
TWM402949U (en) Fast positioning apparatus
GB201005430D0 (en) Semiconductor apparatus
TWM386968U (en) Improved structure of rapid replacing apparatus
TWM433557U (en) Improved structure of material receiving device
GB201002957D0 (en) Voice changing device for decompression chamber
PT2573989T (en) Device for suppressing unwanted high frequency signals
GB201005447D0 (en) Apparatus for retaining
PT2391021T (en) Software-based radio device