SG10201500821UA - Common light chain mouse - Google Patents

Common light chain mouse

Info

Publication number
SG10201500821UA
SG10201500821UA SG10201500821UA SG10201500821UA SG10201500821UA SG 10201500821U A SG10201500821U A SG 10201500821UA SG 10201500821U A SG10201500821U A SG 10201500821UA SG 10201500821U A SG10201500821U A SG 10201500821UA SG 10201500821U A SG10201500821U A SG 10201500821UA
Authority
SG
Singapore
Prior art keywords
light chain
common light
chain mouse
mouse
common
Prior art date
Application number
SG10201500821UA
Other languages
English (en)
Inventor
John Mcwhirter
Lynn Macdonald
Sean Stevens
Samuel Davis
David R Buckler
Andrew J Murphy
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43663643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201500821U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201500821UA publication Critical patent/SG10201500821UA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10201500821UA 2010-02-08 2011-02-08 Common light chain mouse SG10201500821UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30228210P 2010-02-08 2010-02-08

Publications (1)

Publication Number Publication Date
SG10201500821UA true SG10201500821UA (en) 2015-04-29

Family

ID=43663643

Family Applications (4)

Application Number Title Priority Date Filing Date
SG2012057485A SG183149A1 (en) 2010-02-08 2011-02-08 Common light chain mouse
SG10201500821UA SG10201500821UA (en) 2010-02-08 2011-02-08 Common light chain mouse
SG10201913463QA SG10201913463QA (en) 2010-02-08 2011-02-08 Common light chain mouse
SG10201610294RA SG10201610294RA (en) 2010-02-08 2013-03-05 Common light chain mouse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012057485A SG183149A1 (en) 2010-02-08 2011-02-08 Common light chain mouse

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201913463QA SG10201913463QA (en) 2010-02-08 2011-02-08 Common light chain mouse
SG10201610294RA SG10201610294RA (en) 2010-02-08 2013-03-05 Common light chain mouse

Country Status (30)

Country Link
US (5) US10143186B2 (fr)
EP (4) EP3540066A1 (fr)
JP (8) JP5955781B2 (fr)
KR (5) KR101829691B1 (fr)
CN (2) CN105010238B (fr)
AU (1) AU2011213585B2 (fr)
BR (2) BR122014002928A2 (fr)
CA (1) CA2789154C (fr)
CY (2) CY1118241T1 (fr)
DK (3) DK3095871T3 (fr)
ES (3) ES2728942T3 (fr)
HK (2) HK1231505A1 (fr)
HR (3) HRP20151188T4 (fr)
HU (3) HUE026229T2 (fr)
IL (3) IL221265B (fr)
LT (2) LT3095871T (fr)
ME (2) ME02646B (fr)
MX (3) MX350983B (fr)
MY (1) MY166529A (fr)
NZ (4) NZ631363A (fr)
PL (3) PL2505654T5 (fr)
PT (3) PT2505654T (fr)
RS (3) RS55315B2 (fr)
RU (2) RU2724663C2 (fr)
SG (4) SG183149A1 (fr)
SI (3) SI3095871T1 (fr)
SM (2) SMT201500283B (fr)
TR (1) TR201906650T4 (fr)
WO (1) WO2011097603A1 (fr)
ZA (1) ZA201205944B (fr)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
ES2368733T3 (es) 2002-07-18 2011-11-21 Merus B.V. Producción recombinante de mezclas de anticuerpos.
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
EP2395016A3 (fr) 2003-05-30 2012-12-19 Merus B.V. Conception et utilisation de régions variables appariées de molécules de liaison spécifiques
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CN101506235B (zh) 2006-09-01 2012-07-25 人类多细胞株治疗学公司 人或人源化免疫球蛋白在非人转基因动物中增强的表达
EP3456193A1 (fr) * 2008-06-27 2019-03-20 Merus N.V. Mammifères non humains produisant un anticorps
WO2010070263A1 (fr) 2008-12-18 2010-06-24 Erasmus University Medical Center Rotterdam Animaux transgeniques non humains exprimant des anticorps humanises et leur utilisation
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
ES2537239T3 (es) 2009-07-08 2015-06-03 Kymab Limited Modelos de animales y moléculas terapéuticas
BR122014002928A2 (pt) * 2010-02-08 2015-12-29 Regeneron Pharma métodos de produzir um camundongo e um anticorpo e de selecionar uma região variável de cadeia pesada humana para a produção de uma proteína de ligação ao antígeno, uso de um camundongo geneticamente modificado na produção de uma proteína de ligação ao antígeno, bem como anticorpo quimérico e hibridoma
US20120021409A1 (en) * 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
BR122020013427B1 (pt) * 2010-06-22 2021-08-03 Regeneron Pharmaceuticals, Inc Método para fazer um camundongo, uma célula ou tecido derivado de um camundongo e um hibridoma
MX363084B (es) 2010-08-02 2019-03-07 Regeneron Pharma Ratones que producen proteinas de union que comprenden dominios vl.
WO2012071592A2 (fr) * 2010-11-27 2012-05-31 James Zhu Animal transgénique humanisé
CN103429746B (zh) 2011-02-25 2016-05-11 瑞泽恩制药公司 Adam6小鼠
CA2825081A1 (fr) 2011-02-28 2012-09-07 Birgit Bossenmaier Proteines de liaison a un antigene
WO2012116927A1 (fr) 2011-02-28 2012-09-07 F. Hoffmann-La Roche Ag Protéines monovalentes de liaison à l'antigène
SG2014007686A (en) * 2011-08-05 2014-03-28 Regeneron Pharma Humanized universal light chain mice
WO2013041845A2 (fr) * 2011-09-19 2013-03-28 Kymab Limited Animaux, répertoires & procédés
CN103945689B (zh) 2011-09-19 2016-10-19 科马布有限公司 免疫球蛋白基因多样性的操纵及多抗体治疗剂
CA2791109C (fr) 2011-09-26 2021-02-16 Merus B.V. Generation de molecules de liaison
WO2013045916A1 (fr) 2011-09-26 2013-04-04 Kymab Limited Chaînes légères substituts (cls) chimères comprenant vpreb humain
GB2495083A (en) * 2011-09-26 2013-04-03 Kymab Ltd Human VpreB and chimaeric surrogate light chains in transgenic non-human vertebrates
BR112014007487A2 (pt) * 2011-09-30 2017-04-04 Dana Farber Cancer Inst Inc peptídeos terapêuticos
EP4074833A1 (fr) 2011-10-17 2022-10-19 Regeneron Pharmaceuticals, Inc. Souris à chaîne lourde d'immunoglobuline limitée
WO2013063391A2 (fr) 2011-10-28 2013-05-02 Trianni, Inc. Animaux transgéniques et leurs procédés d'utilisation
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
RU2664181C2 (ru) 2011-12-20 2018-08-15 Регенерон Фармасьютикалз, Инк. Мыши с гуманизированной легкой цепью
SG10201610123UA (en) 2012-03-02 2017-01-27 Regeneron Pharma Human antibodies to clostridium difficile toxins
SG11201405088QA (en) * 2012-03-06 2014-11-27 Regeneron Pharma Common light chain mouse
AU2015227453B2 (en) * 2012-03-16 2017-05-25 Regeneron Pharmaceuticals, Inc. Non-human animals expressing ph-sensitive immunoglobulin sequences
HUE045537T2 (hu) * 2012-03-16 2019-12-30 Regeneron Pharma PH-érzékeny immunglobulin-szekvenciákat expresszáló rágcsálók
US20140013456A1 (en) 2012-03-16 2014-01-09 Regeneron Pharmaceuticals, Inc. Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
LT2883449T (lt) 2012-03-16 2018-05-10 Regeneron Pharmaceuticals, Inc. Histidinu modifikuoti lengvosios grandinės antikūnai ir juos gaminantys genetiškai modifikuoti graužikai
KR20140134672A (ko) * 2012-03-16 2014-11-24 리제너론 파마슈티칼스 인코포레이티드 pH-의존성 결합 특성을 나타내는 항원-결합 단백질을 생성하는 마우스
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
WO2013157953A1 (fr) 2012-04-20 2013-10-24 Merus B.V. Procédés et moyens de production de molécules de type ig
CA2872908C (fr) * 2012-05-10 2023-11-14 Gerhard Frey Anticorps monoclonaux multi-specifiques
JP2015525071A (ja) * 2012-06-05 2015-09-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法
NZ717848A (en) 2012-06-12 2019-03-29 Regeneron Pharma Humanized non-human animals with restricted immunoglobulin heavy chain loci
WO2014022540A1 (fr) 2012-08-02 2014-02-06 Regeneron Pharmaceuticals, Inc. Protéines multivalentes de liaison à un antigène
JO3462B1 (ar) 2012-08-22 2020-07-05 Regeneron Pharma أجسام مضادة بشرية تجاه gfr?3 وطرق لاستخدامها
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
HUE042040T2 (hu) 2012-09-27 2019-06-28 Merus Nv Bispecifikus IGG antitestek mint T-sejt kapcsolók
SI2943511T1 (sl) 2013-01-14 2020-01-31 Xencor, Inc. Novi heterodimerni proteini
CA2900832A1 (fr) * 2013-02-20 2014-08-28 Regeneron Pharmaceuticals, Inc. Souris exprimant des co-recepteurs de lymphocytes t humanises
KR20160025033A (ko) 2013-02-20 2016-03-07 리제너론 파마슈티칼스 인코포레이티드 변형된 면역글로불린 중쇄 서열을 갖는 비인간 동물
US10154658B2 (en) * 2013-02-22 2018-12-18 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
CN108464278B (zh) * 2013-03-11 2021-05-04 瑞泽恩制药公司 表达嵌合的主要组织相容性复合物(mhc)ii类分子的转基因小鼠
CN105189545A (zh) * 2013-03-13 2015-12-23 瑞泽恩制药公司 常见轻链小鼠
BR112015022034B1 (pt) * 2013-03-13 2023-02-28 Regeneron Pharmaceuticals, Inc Método de fabricar um camundongo, e, para fabricar um anticorpo
EP3841876A1 (fr) 2013-03-14 2021-06-30 Erasmus University Medical Center Rotterdam Souris transgénique destiné à la production d'anticorps
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
KR102049990B1 (ko) 2013-03-28 2019-12-03 삼성전자주식회사 c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
SG10201800492PA (en) 2013-04-29 2018-03-28 Hoffmann La Roche Human fcrn-binding modified antibodies and methods of use
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US20150033372A1 (en) * 2013-05-01 2015-01-29 Kymab Limited Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
CN111019953A (zh) 2013-09-18 2020-04-17 瑞泽恩制药公司 组氨酸工程改造的轻链抗体和用于生成所述抗体的经基因修饰的非人动物
CA2922950A1 (fr) 2013-09-30 2015-04-02 Shinya Ishii Procede de production d'une molecule de liaison a l'antigene dans lequel on utilise un phage auxiliaire modifie
DE112014004537T5 (de) * 2013-10-01 2016-07-21 Kymab Limited Tiermodelle und therapeutische Moleküle
MX2016003593A (es) 2013-10-11 2016-06-02 Hoffmann La Roche Anticuerpos de cadena ligera variable comun intercambiada de dominio multiespecifico.
EP3094648A1 (fr) 2014-01-15 2016-11-23 F. Hoffmann-La Roche AG Variants de région fc présentant une liaison améliorée à la protéine a
RU2727639C2 (ru) 2014-01-15 2020-07-22 Ф.Хоффманн-Ля Рош Аг Варианты fc-области с модифицированной способностью связываться с fcrn и с сохраненной способностью связываться с белком а
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
EP3470435B1 (fr) 2014-02-28 2020-08-05 Merus N.V. Anticorps liant erbb-2 et erbb-3
US10844127B2 (en) 2014-02-28 2020-11-24 Merus N.V. Antibodies that bind EGFR and ErbB3
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
AU2015230938C1 (en) 2014-03-21 2021-10-14 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
BR112016021679A2 (pt) 2014-03-21 2018-12-04 Regeneron Pharmaceuticals, Inc. proteína de ligação ao antígeno, métodos de produção de uma proteína de ligação ao antígeno e de identificação de uma ou mais proteínas de ligação ao antígeno, hibridoma, ácido nucleico, célula, e, animal não humano geneticamente modificado.
MY186389A (en) 2014-05-13 2021-07-22 Univ Pennsylvania Compositions comprising aav expressing dual antibody constructs and uses thereof
LT3151921T (lt) 2014-06-06 2019-12-10 Bristol Myers Squibb Co Antikūnai prieš gliukokortikoidu indukuojamą naviko nekrozės faktoriaus receptorių (gitr) ir jų panaudojimas
JP2017529841A (ja) 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． キメラ抗原受容体
WO2016054598A2 (fr) 2014-10-03 2016-04-07 Massachusetts Institute Of Technology Anticorps qui se lient à la glycoprotéine du virus ébola et utilisations associés
MX2017005150A (es) 2014-11-06 2017-08-08 Hoffmann La Roche Variantes de region fc con propiedades modificadas de union a receptor neonatal fc (fcrn) y proteina a.
KR102614189B1 (ko) 2014-11-17 2023-12-18 리제너론 파아마슈티컬스, 인크. Cd3xcd20 이특이적 항체를 이용한 종양의 치료 방법
JP6805142B2 (ja) 2014-11-21 2020-12-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃｄ７３に対する抗体およびその使用
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
NZ732144A (en) 2014-11-26 2020-04-24 Xencor Inc Heterodimeric antibodies that bind cd3 and tumor antigens
WO2016097865A1 (fr) 2014-12-19 2016-06-23 Regenesance B.V. Anticorps qui se lient au c6 humain et utilisations de ceux-ci
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
CN107207594B (zh) 2014-12-23 2019-05-07 百时美施贵宝公司 针对tigit的抗体
AU2016232715A1 (en) 2015-03-19 2017-09-28 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
KR20180010264A (ko) 2015-05-29 2018-01-30 브리스톨-마이어스 스큅 컴퍼니 Ox40에 대한 항체 및 그의 용도
EP3313886A1 (fr) 2015-06-29 2018-05-02 The Rockefeller University Anticorps anti-cd40 présentant une activité agoniste renforcée
SG10202112460VA (en) 2015-07-06 2021-12-30 Regeneron Pharma Multispecific antigen-binding molecules and uses thereof
EA201890028A1 (ru) 2015-07-10 2018-08-31 Мерус Н.В. Антитело, связывающее cd3 человека
JOP20160154B1 (ar) 2015-07-31 2021-08-17 Regeneron Pharma أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها
JP7023231B2 (ja) 2015-09-23 2022-02-21 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 最適化抗ｃｄ３二重特異性抗体及びその使用
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
KR20180100305A (ko) 2015-10-23 2018-09-10 메뤼스 엔.페. 암 성장을 억제하는 결합 분자
SG11201803817PA (en) 2015-11-19 2018-06-28 Bristol Myers Squibb Co Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
IL313952A (en) 2015-12-22 2024-08-01 Regeneron Pharma Combination of anti-PD-1 antibodies and bispecific anti-CD20 / anti-CD3 antibodies for cancer treatment
JP6979955B2 (ja) 2016-01-13 2021-12-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. 操作された重鎖可変領域を有する齧歯類
JP2019514844A (ja) 2016-03-04 2019-06-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｃｄ７３抗体を用いた併用療法
CN116063494A (zh) 2016-03-04 2023-05-05 洛克菲勒大学 具有增强的激动剂活性的cd40的抗体
EP3448891A1 (fr) 2016-04-28 2019-03-06 Regeneron Pharmaceuticals, Inc. Procédés de production de molécules multispécifiques se liant à l'antigène
MX2018013072A (es) 2016-05-09 2019-03-21 Squibb Bristol Myers Co Anticuerpos del ligando similar al factor de necrosis tumoral 1a (tl1a) y usos de los mismos.
TWI786044B (zh) 2016-05-13 2022-12-11 美商再生元醫藥公司 藉由投予ｐｄ-１抑制劑治療皮膚癌之方法
US20170332610A1 (en) 2016-05-20 2017-11-23 Regeneron Pharmaceuticals, Inc. Methods for breaking immunological tolerance using multiple guide rnas
SG11201810757YA (en) 2016-06-03 2018-12-28 Regeneron Pharma Non-human animals expressing exogenous terminal deoxynucleotidyltransferase
EP4374922A3 (fr) 2016-06-14 2024-08-28 Regeneron Pharmaceuticals, Inc. Anticorps anti-c5 et leurs utilisations
CA3029209A1 (fr) * 2016-06-21 2017-12-28 Teneobio, Inc. Anticorps se liant a cd3
CN116063545A (zh) 2016-06-28 2023-05-05 Xencor股份有限公司 结合生长抑素受体2的异源二聚抗体
UY37325A (es) 2016-07-14 2018-01-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Anticuerpos monoclonales que se enlazan a tim3 para estimular respuestas inmunitarias y composiciones que los contienen
AU2017315146A1 (en) 2016-08-26 2019-04-11 Sanofi Multispecific antibodies facilitating selective light chain pairing
WO2018044970A1 (fr) 2016-08-31 2018-03-08 University Of Rochester Anticorps monoclonaux humains dirigés contre l'enveloppe du rétrovirus endogène humain k (herv-k) et leurs utilisations
CN109843325B (zh) * 2016-09-14 2023-10-03 特尼奥生物股份有限公司 Cd3结合抗体
AU2017331361B2 (en) 2016-09-23 2024-07-18 Regeneron Pharmaceuticals, Inc. Anti-STEAP2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind STEAP2 and CD3, and uses thereof
RS63660B1 (sr) 2016-09-23 2022-11-30 Regeneron Pharma Anti-muc16 (mucin 16) antitela
AU2017343778A1 (en) 2016-10-13 2019-05-02 Massachusetts Institute Of Technology Antibodies that bind Zika virus envelope protein and uses thereof
MA46814B2 (fr) 2017-02-10 2022-09-30 Regeneron Pharma Anticorps anti-lag3 radiomarqués pour imagerie immuno-pet
CN110506057B (zh) 2017-02-17 2023-09-29 百时美施贵宝公司 Alpha突触核蛋白抗体及其应用
EP3589650A1 (fr) 2017-03-02 2020-01-08 Novartis AG Protéines hétérodimères modifiées
SG11201908971RA (en) 2017-03-31 2019-10-30 Merus Nv Erbb-2 and erbb3 binding bispecific antibodies for use in the treatment f cells that have an nrg1 fusion gene
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
CA3065951A1 (fr) 2017-06-20 2018-12-27 Teneoone, Inc. Anticorps uniquement a chaines lourdes anti-bcma
WO2018237037A2 (fr) 2017-06-20 2018-12-27 Teneobio, Inc. Anticorps à chaîne lourde uniquement anti-bcma
GB201710984D0 (en) * 2017-07-07 2017-08-23 Kymab Ltd Cells, vertebrates, populations & methods
TW202348250A (zh) 2017-07-24 2023-12-16 美商再生元醫藥公司 穩定化之抗體組合物及其製法
CN111094351B (zh) 2017-08-09 2024-07-12 美勒斯公司 结合EGFR和cMET的抗体
MX2020002976A (es) 2017-09-29 2020-07-24 Regeneron Pharma Moleculas de union a antigeno biespecificas que se unen a un antigeno objetivo de staphylococcus y a un componente de complemento, y usos de las mismas.
WO2019118556A1 (fr) 2017-12-13 2019-06-20 Regeneron Pharmaceuticals, Inc. Associations d'anticorps anti-c5 et utilisations associées
AU2018392088A1 (en) 2017-12-22 2020-08-13 Teneobio, Inc. Heavy chain antibodies binding to CD22
CN111886255A (zh) 2018-01-12 2020-11-03 百时美施贵宝公司 抗tim3抗体及其用途
CN111670195B (zh) 2018-01-26 2024-08-13 瑞泽恩制药公司 针对流感血凝素的人抗体
SG11202008767XA (en) 2018-03-23 2020-10-29 Bristol Myers Squibb Co Antibodies against mica and/or micb and uses thereof
SG11202008799PA (en) 2018-03-24 2020-10-29 Regeneron Pharma Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
WO2019212965A1 (fr) 2018-04-30 2019-11-07 Regeneron Pharmaceuticals, Inc. Anticorps et molécules de liaison à l'antigène bispécifiques se liant à her2 et/ou aplp2, conjugués et utilisations associées
MX2020012350A (es) 2018-05-17 2021-01-29 Regeneron Pharma Anticuerpos anti-cd63, conjugados y usos de estos.
IL305557A (en) 2018-06-14 2023-10-01 Regeneron Pharma Non-human animals with transgenic DH–DH rearrangement capacity, and their uses
MX2020013804A (es) 2018-06-21 2021-03-31 Regeneron Pharma Anticuerpos anti-psma x anti-cd28 biespecíficos y usos de estos.
TWI838389B (zh) 2018-07-19 2024-04-11 美商再生元醫藥公司 雙特異性抗-BCMAｘ抗-CD3抗體及其用途
KR20210049863A (ko) 2018-08-23 2021-05-06 리제너론 파아마슈티컬스, 인크. 항-Fc 엡실론-R1 알파 (FCERIA) 항체, FCERIA 및 CD3에 결합하는 이중특이적 항원-결합 분자 및 이들의 용도
WO2020047389A1 (fr) 2018-08-31 2020-03-05 Regeneron Pharmaceuticals, Inc. Stratégie de dosage permettant d'atténuer le syndrome de libération de cytokines pour des anticorps bispécifiques cd3/c20
JP7439076B2 (ja) 2018-10-23 2024-02-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗ｎｐｒ１抗体およびその使用
AU2019380307A1 (en) 2018-11-16 2021-07-01 Bristol-Myers Squibb Company Anti-NKG2A antibodies and uses thereof
JP7463366B2 (ja) 2018-11-20 2024-04-08 タケダ ワクチン，インコーポレイテッド 新規の抗ジカウイルス抗体及びその使用
CN112867732A (zh) 2018-11-21 2021-05-28 瑞泽恩制药公司 抗葡萄球菌抗体和其用途
WO2020132066A1 (fr) 2018-12-19 2020-06-25 Regeneron Pharmaceuticals, Inc. Anticorps anti-cd28 x anti-cd22 bispécifiques et leurs utilisations
AU2019405736A1 (en) 2018-12-19 2021-06-24 Regeneron Pharmaceuticals, Inc. Bispecific anti-MUC16 x anti-CD28 antibodies and uses thereof
WO2020132557A1 (fr) 2018-12-21 2020-06-25 Compass Therapeutics Llc Souris transgénique exprimant une chaîne légère humaine commune
EP3914622A1 (fr) 2019-01-22 2021-12-01 Bristol-Myers Squibb Company Anticorps contre la sous-unité alpha d'un l'il-7r et leurs utilisations
CN117099741A (zh) 2019-02-18 2023-11-24 百奥赛图(北京)医药科技股份有限公司 具有人源化免疫球蛋白基因座的经遗传修饰的非人动物
SG11202107589PA (en) 2019-02-22 2021-08-30 Regeneron Pharma Rodents having genetically modified sodium channels and methods of use thereof
MX2021011500A (es) 2019-03-22 2021-10-22 Regeneron Pharma Anticuerpos multiespecificos egfr x cd28.
BR112021023683A2 (pt) 2019-06-05 2022-02-01 Regeneron Pharma Roedor e camundongo geneticamente modificado, embrião de roedor, célula b do roedor ou camundongo geneticamente modificado, hibridoma, população de células b, célula-tronco embrionária, célula de mamífero, métodos de produção de um anticorpo, de uma cadeia pesada, de um domínio variável, de uma coleção de domínios variáveis, de uma cadeia leve, de uma sequência nucleotídica, de um roedor geneticamente modificado e de células es, de geração de um domínio variável e in vitro para gerar uma célula recombinante de roedor, e, vetor de direcionamento
AU2020292283A1 (en) 2019-06-11 2021-12-23 Regeneron Pharmaceuticals, Inc. Anti-PcrV antibodies that bind PcrV, compositions comprising anti-PcrV antibodies, and methods of use thereof
UY38748A (es) 2019-06-14 2021-01-29 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
US20200399372A1 (en) 2019-06-21 2020-12-24 Regeneron Pharmaceuticals, Inc. Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation
AU2020294790A1 (en) 2019-06-21 2021-12-16 Regeneron Pharmaceuticals, Inc. Use of bispecific antigen-binding molecules that bind MUC16 and CD3 in combination with 4-1BB co-stimulation
JP2022543669A (ja) 2019-08-08 2022-10-13 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 新規抗原結合分子フォーマット
JP2022545647A (ja) 2019-08-15 2022-10-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 細胞標的化のための多重特異性抗原結合分子およびそれらの使用
GB201912008D0 (en) 2019-08-21 2019-10-02 Cambridge Entpr Ltd Antibody
BR112022007923A2 (pt) 2019-10-28 2022-07-26 Regeneron Pharma Anticorpo recombinante isolado ou fragmento de ligação ao antígeno deste, composição farmacêutica, molécula de polinucleotídeo, vetor, célula, e, método para prevenir, tratar ou melhorar pelo menos um sintoma da infecção por influenza
CA3163549A1 (fr) 2019-12-02 2021-06-10 Regeneron Pharmaceuticals, Inc. Constructions proteiques de peptide-cmh ii et leurs utilisations
AU2020398167A1 (en) 2019-12-06 2022-07-28 Regeneron Pharmaceuticals, Inc. Methods of treating multiple myeloma with bispecific anti-BCMA x anti-CD3 antibodies
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
US11945872B2 (en) 2020-02-11 2024-04-02 Regeneron Pharmaceuticals, Inc. Anti-ACVR1 antibodies and uses thereof
US20230203161A1 (en) 2020-04-29 2023-06-29 Teneobio, Inc Multispecific heavy chain antibodies with modified heavy chain constant regions
EP4149976A1 (fr) 2020-05-12 2023-03-22 Regeneron Pharmaceuticals, Inc. Anticorps antagonistes anti-glp1r et leurs procédés d'utilisation
US11919956B2 (en) 2020-05-14 2024-03-05 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
AU2021283564A1 (en) 2020-06-02 2022-12-08 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animals with common light chain immunoglobulin locus
KR20230166150A (ko) 2020-08-19 2023-12-06 젠코어 인코포레이티드 항-cd28 조성물
IL301137A (en) 2020-09-11 2023-05-01 Regeneron Pharma Identification and production of antigen-specific antibodies
US11905332B2 (en) 2020-09-18 2024-02-20 Regeneron Pharmaceuticals, Inc. Antigen-binding molecules that bind CD38 and/or CD28, and uses thereof
IL301702A (en) 2020-10-22 2023-05-01 Regeneron Pharma Anti-FGFR2 antibodies and methods of using them
CN114524878B (zh) 2020-11-23 2024-08-02 康诺亚生物医药科技（成都）有限公司 一种双特异性抗体及其用途
EP4262373A1 (fr) 2020-12-16 2023-10-25 Regeneron Pharmaceuticals, Inc. Souris exprimant des récepteurs humanisés fc alpha
AU2021410655A1 (en) 2020-12-23 2023-06-29 Regeneron Pharmaceuticals, Inc. Nucleic acids encoding anchor modified antibodies and uses thereof
WO2022140494A1 (fr) 2020-12-23 2022-06-30 Regeneron Pharmaceuticals, Inc. Procédés d'obtention d'anticorps qui se lient à des protéines transmembranaires et cellules qui les produisent
CN116963774A (zh) 2021-01-28 2023-10-27 瑞泽恩制药公司 用于治疗细胞因子释放综合征的组合物和方法
KR20230156079A (ko) 2021-03-09 2023-11-13 젠코어 인코포레이티드 Cd3과 cldn6에 결합하는 이종이량체 항체
WO2022192586A1 (fr) 2021-03-10 2022-09-15 Xencor, Inc. Anticorps hétérodimères qui se lient au cd3 et au gpc3
CA3239802A1 (fr) 2021-12-06 2023-06-15 Regeneron Pharmaceuticals, Inc. Anticorps anti-npr1 antagonistes et leurs procedes d'utilisation
TW202400228A (zh) 2022-02-25 2024-01-01 美商再生元醫藥公司 減輕細胞激素釋放症候群的給藥方案
WO2023196903A1 (fr) 2022-04-06 2023-10-12 Regeneron Pharmaceuticals, Inc. Molécules bispécifiques de liaison à l'antigène qui se lient et cd3 et antigènes associés à une tumeur (taa) et leurs utilisations
WO2023201226A1 (fr) 2022-04-11 2023-10-19 Regeneron Pharmaceuticals, Inc. Compositions et méthodes permettant la destruction de cellule tumorale universelle
US20230416396A1 (en) 2022-05-18 2023-12-28 Regeneron Pharmaceuticals, Inc. Multispecific antigen binding molecules that bind cd38 and 4-1bb, and uses thereof
WO2024015816A1 (fr) 2022-07-12 2024-01-18 Regeneron Pharmaceuticals, Inc. Anticorps dirigés contre le récepteur du facteur neurotrophique ciliaire (cntfr) et leurs procédés d'utilisation
WO2024092133A1 (fr) 2022-10-27 2024-05-02 Regeneron Pharmaceuticals, Inc. Anticorps anti-acvr1 et leur utilisation dans le traitement de l'ossification hétérotopique résultant d'un traumatisme
GB202217978D0 (en) * 2022-11-30 2023-01-11 Petmedix Ltd Rodents expressing a common light chain
WO2024155620A1 (fr) 2023-01-18 2024-07-25 Gilead Sciences, Inc. Constructions transgéniques de chaîne légère binaire d'immunoglobuline humaine et leurs utilisations
WO2024163477A1 (fr) 2023-01-31 2024-08-08 University Of Rochester Thérapie de blocage de point de contrôle immunitaire pour le traitement d'infections par staphylococcus aureus
WO2024173248A1 (fr) 2023-02-13 2024-08-22 Regeneron Pharmaceuticals, Inc. Traitement de troubles musculaires avec des anticorps anti-cacng1 humains
WO2024173830A2 (fr) 2023-02-17 2024-08-22 Regeneron Pharmaceuticals, Inc. Cellules nk induites sensibles à des anticorps bispécifiques cd3/taa

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990002569A1 (fr) 1988-09-06 1990-03-22 International Genetic Engineering, Inc. Production d'anticorps chimeriques murins-humains a specificite pour des antigenes de tumeurs humains
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
WO1991000906A1 (fr) † 1989-07-12 1991-01-24 Genetics Institute, Inc. Animaux chimeriques et transgeniques pouvant produire des anticorps humains
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
EP0737746A3 (fr) 1989-12-01 1996-10-23 Pharming B.V. Production de polypeptides recombinants par l'espèce bovine et procédés transgéniques
ATE356869T1 (de) 1990-01-12 2007-04-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
US6657103B1 (en) 1990-01-12 2003-12-02 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1994025585A1 (fr) 1993-04-26 1994-11-10 Genpharm International, Inc. Animaux transgeniques capables de produire des anticorps heterologues
US7084260B1 (en) 1996-10-10 2006-08-01 Genpharm International, Inc. High affinity human antibodies and human antibodies against human antigens
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5667988A (en) 1992-01-27 1997-09-16 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US7067284B1 (en) 1992-01-27 2006-06-27 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
ATE381614T1 (de) 1992-07-24 2008-01-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
DE69308573T2 (de) 1992-08-17 1997-08-07 Genentech Inc Bispezifische immunoadhesine
US5693506A (en) 1993-11-16 1997-12-02 The Regents Of The University Of California Process for protein production in plants
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
ATE213771T1 (de) 1993-12-23 2002-03-15 Infigen Inc Embryonale stammzellen von huftieren als kerndonatoren und kerntransfertechniken zur herstellung chimärer und transgener tiere
EP0744958B1 (fr) 1994-01-31 2003-06-25 Trustees Of Boston University Banques d'anticorps polyclonaux
US7119248B1 (en) 1994-04-12 2006-10-10 Miltenyi Biotec Gmbh Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
US6080560A (en) 1994-07-25 2000-06-27 Monsanto Company Method for producing antibodies in plant cells
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
EP0826696B1 (fr) 1996-09-03 2002-05-29 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Utilisation des anticorps bi- et trispécifiques pour induire une immunité antitumorale
EP2305027B1 (fr) 1996-12-03 2014-07-02 Amgen Fremont Inc. Mammifères trangèniques obtenus par génie génétique contenant des loci des immunoglobulines humaines qui comprennent plusieurs régions de VH et de Vkappa, et anticorps aussi obtenus.
EP0973871A1 (fr) 1997-03-06 2000-01-26 Infigen, Inc. Methode de clonage d'animaux
US7227002B1 (en) 1997-04-14 2007-06-05 Micromet Ag Human antibodies that bind human 17-A1/EpCAM tumor antigen
US20020062010A1 (en) * 1997-05-02 2002-05-23 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
CA2288600C (fr) 1997-05-02 2010-06-01 Genentech, Inc. Procede de preparation d'anticorps multispecifiques presentant des composants heteromultimeres
US6774279B2 (en) 1997-05-30 2004-08-10 Carnegie Institution Of Washington Use of FLP recombinase in mice
RU2221809C2 (ru) 1997-10-03 2004-01-20 Тугаи Сейяку Кабусики Кайся Способ получения природного гуманизированного антитела
DK1034262T3 (da) 1997-11-18 2005-11-28 Pioneer Hi Bred Int Sammensætninger og fremgangsmåder til genetisk modifikation af planter
GB9823930D0 (en) 1998-11-03 1998-12-30 Babraham Inst Murine expression of human ig\ locus
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
ES2335775T3 (es) 1999-04-15 2010-04-05 Crucell Holland B.V. Produccion de protenia recombinante en una celula humana que comprende al menos una proteina e1 de adenovirus.
CA2401965A1 (fr) 2000-02-29 2001-09-07 Auburn University Production d'anticorps dans des plastes transgeniques
CN101498731A (zh) 2000-05-18 2009-08-05 日本烟草产业株式会社 抗协同刺激信号转导分子ailim的人单克隆抗体及其药物用途
WO2002008409A2 (fr) 2000-07-21 2002-01-31 The United States Of America, As Represented By The Secretary Of Agriculture Procedes de remplacement, transposition et empilage de l'adn dans des genomes eucaryotes
WO2002012437A2 (fr) 2000-08-03 2002-02-14 Schooten Wim Van Production d'anticorps humanises dans des animaux transgeniques
EP1184458A1 (fr) 2000-08-28 2002-03-06 U-BISys B.V. Epitopes de CD46 exprimés différentiellement, des molécules protéiniques capables de s'y lier, et leurs utilisations
US20020119148A1 (en) 2000-09-01 2002-08-29 Gerritsen Mary E. ErbB4 antagonists
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
PL217921B1 (pl) 2001-01-05 2014-09-30 Amgen Fremont Inc Przeciwciało przeciw receptorowi insulinopodobnego czynnika wzrostu I, zawierająca go kompozycja farmaceutyczna, sposób jego wytwarzania, zastosowania, linia komórkowa, wyizolowana cząsteczka kwasu nukleinowego, wektor, komórka gospodarza oraz zwierzę transgeniczne
US6961875B2 (en) 2001-03-22 2005-11-01 International Business Machines Corporation Method and apparatus for capturing event traces for debug and analysis
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
JP4303105B2 (ja) 2001-06-28 2009-07-29 ドマンティス リミテッド 二重特異性リガンドとその利用
AU2002368077B2 (en) 2001-07-12 2010-03-04 Jefferson Foote Super humanized antibodies
WO2003062370A2 (fr) 2001-07-19 2003-07-31 Perlan Therapeutics, Inc. Proteines multimeres et methodes de production et d'utilisation de ces proteines
ES2350248T3 (es) 2001-10-01 2011-01-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Procedimiento de producción de bibliotecas de proteínas y de selección de proteínas a partir de las mismas.
WO2003031656A1 (fr) 2001-10-05 2003-04-17 United States Environmental Protection Agency Evaluation genetique du facteur de sterilite masculine
US20060199204A1 (en) 2001-10-05 2006-09-07 U.S. Epa Genetic testing for male factor infertility
CA2847885C (fr) 2001-11-30 2022-03-22 Amgen Fremont Inc. Animaux transgeniques porteurs de genes a chaine legere iglamba d'immunoglobuline humaine
GB0130267D0 (en) 2001-12-19 2002-02-06 Neutec Pharma Plc Focussed antibody technology
US20050095712A1 (en) 2002-01-17 2005-05-05 Alberto Martin Mutations caused by activation-induced cytidine deaminase
EP1470161A1 (fr) 2002-01-18 2004-10-27 Inovio AS Constructions d'adn d'anticorps bispecifique pour administration intramusculaire muscle
JP4518941B2 (ja) 2002-04-26 2010-08-04 中外製薬株式会社 アゴニスト抗体のスクリーニング方法
CN1675245B (zh) 2002-06-14 2011-01-12 免疫医疗公司 人源化单克隆抗体hPAM4
CN101962408A (zh) 2002-07-12 2011-02-02 杰斐逊·富特 超人源化抗体
ES2368733T3 (es) * 2002-07-18 2011-11-21 Merus B.V. Producción recombinante de mezclas de anticuerpos.
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
GB0228210D0 (en) 2002-12-03 2003-01-08 Babraham Inst Single chain antibodies
GB0230203D0 (en) 2002-12-27 2003-02-05 Domantis Ltd Fc fusion
EP1439234A1 (fr) 2003-01-08 2004-07-21 ARTEMIS Pharmaceuticals GmbH Transgénèse ciblée utilisant le locus 26
ATE431423T1 (de) 2003-01-21 2009-05-15 Chugai Pharmaceutical Co Ltd Verfahren zum screening der leichten kette eines antikörpers
AU2004208031B2 (en) 2003-01-28 2009-10-08 Cellectis Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
CA2517519A1 (fr) 2003-03-04 2004-09-16 Alexion Pharmaceuticals, Inc. Vecteurs utilises pour creer des regions hybrides constantes
EP2395016A3 (fr) 2003-05-30 2012-12-19 Merus B.V. Conception et utilisation de régions variables appariées de molécules de liaison spécifiques
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
US7585668B2 (en) 2003-07-15 2009-09-08 Therapeutic Human Polyclonals, Inc. Humanized immunoglobulin loci
WO2005019463A1 (fr) 2003-08-11 2005-03-03 Therapeutic Human Polyclonals, Inc. Amelioration de la transgenese a l'aide de loci d'immunoglobuline humanises
WO2005038001A2 (fr) 2003-10-14 2005-04-28 Therapeutic Human Polyclonals, Inc. Transgenese amelioree par transfert genique a mediation spermatique
DK1709081T3 (da) 2004-01-16 2011-06-06 Regeneron Pharma Fusionspolypeptider, der kan aktivere receptorer
CN1560081A (zh) 2004-02-17 2005-01-05 大连帝恩生物工程有限公司 用能产生人IgGl重链－κ轻链小鼠作为制备人源化单克隆抗体和应用
US7625549B2 (en) 2004-03-19 2009-12-01 Amgen Fremont Inc. Determining the risk of human anti-human antibodies in transgenic mice
DK1802193T3 (da) 2004-10-19 2014-06-10 Regeneron Pharma Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation
CN101084317A (zh) 2004-10-22 2007-12-05 人类多克隆治疗公司 对内源免疫球蛋白表达的抑制
CN102731654A (zh) * 2004-10-22 2012-10-17 米迪缪尼有限公司 抗hmgb1的高亲和力抗体及其用法
WO2006117699A2 (fr) 2005-04-29 2006-11-09 Innate Pharma Animaux transgeniques et procedes de fabrication d'anticorps recombines
US20100154070A1 (en) 2005-05-14 2010-06-17 Tian Xu PiggyBac as a Tool for Genetic Manipulation and Analysis in Vertebrates
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
AU2006322445B2 (en) * 2005-12-05 2011-05-12 Symphogen A/S Anti-orthopoxvirus recombinant polyclonal antibody
SG169348A1 (en) 2006-01-25 2011-03-30 Univ Erasmus Medical Ct Generation of heavy-chain only antibodies in transgenic animals
US7462759B2 (en) 2006-02-03 2008-12-09 Pioneer Hi-Bred International, Inc. Brittle stalk 2 gene family and related methods and uses
US7910798B2 (en) 2006-03-31 2011-03-22 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
CN102585002A (zh) 2006-06-02 2012-07-18 瑞泽恩制药公司 人il-6受体的高亲和力抗体
CN101501073A (zh) 2006-08-22 2009-08-05 G2英弗勒美欣私人有限公司 抗体制备方法
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
EP2069403B1 (fr) 2006-10-02 2014-05-07 Regeneron Pharmaceuticals, Inc. Anticorps humains à haute affinité vis-à-vis du récepteur il-4 humain
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
GB0700194D0 (en) 2007-01-05 2007-02-14 Univ Edinburgh Humanisation of animals
CN101688228B (zh) 2007-03-13 2014-12-24 国家犾太健康中心 抗体产生的方法
CN101784664B (zh) 2007-06-01 2013-04-10 Omt公司 用于抑制内源性免疫球蛋白基因和生产转基因人独特型抗体的组合物和方法
WO2009013620A2 (fr) 2007-06-11 2009-01-29 Erasmus University Medical Center Rotterdam Recombinaison homologue
ITMI20071522A1 (it) * 2007-07-27 2009-01-28 Areta Internat S R L Vaccino idiotipico
EP3255144A1 (fr) 2007-08-10 2017-12-13 E. R. Squibb & Sons, L.L.C. Construction de type recombineering pour la préparation de souris transgeniques capables de produire des immunoglobulines humaines.
CA2695374A1 (fr) 2007-08-15 2009-02-19 Amunix, Inc. Compositions et procedes d'amelioration de la production de polypeptides recombines
US8691730B2 (en) 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP2211903A4 (fr) 2007-10-17 2011-07-06 Nuvelo Inc Anticorps anti-cll-1
BRPI0821658B8 (pt) 2007-12-14 2021-05-25 Novo Nordisk As anticorpo monoclonal humano ou um fragmento de ligação ao antígeno do mesmo que se liga a hnkg2d e seus usos
MX350962B (es) 2008-01-07 2017-09-27 Amgen Inc Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion.
CA2721231C (fr) 2008-04-14 2015-10-06 Innovative Targeting Solutions Inc. Creation de diversite de sequences dans des immunoglobulines
AU2009248834B2 (en) 2008-05-23 2014-10-30 Ablexis Llc Method of generating single VL domain antibodies in transgenic animals
EP3456193A1 (fr) 2008-06-27 2019-03-20 Merus N.V. Mammifères non humains produisant un anticorps
LT2346994T (lt) 2008-09-30 2022-03-10 Ablexis, Llc Knock-in pelė, skirta chimerinių antikūnų gamybai
JP5882058B2 (ja) 2008-11-07 2016-03-09 ファブラス エルエルシー 組合せ抗体ライブラリー及びその使用
WO2010070263A1 (fr) 2008-12-18 2010-06-24 Erasmus University Medical Center Rotterdam Animaux transgeniques non humains exprimant des anticorps humanises et leur utilisation
EP2401298A1 (fr) 2009-02-24 2012-01-04 Glaxo Group Limited Constructions de liaison d'antigène
US8808136B2 (en) 2009-05-07 2014-08-19 Volvo Construction Equipment Ab Working machine and a method for operating a working machine
CA2758356C (fr) 2009-05-29 2016-07-26 Morphosys Ag Une collection de paires de vh et de vl ayant des proprietes biophysiques favorables et ses methodes d'utilisation
EP3916011A1 (fr) 2009-06-26 2021-12-01 Regeneron Pharmaceuticals, Inc. Anticorps bispécifiques facilement isolés avec un format natif d'immunoglobuline
ES2537239T3 (es) 2009-07-08 2015-06-03 Kymab Limited Modelos de animales y moléculas terapéuticas
US9315824B2 (en) 2009-11-17 2016-04-19 Sab, Llc Human artificial chromosome vector
JP5909449B2 (ja) 2009-12-10 2016-04-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 重鎖抗体を作製するマウス
US20130045492A1 (en) 2010-02-08 2013-02-21 Regeneron Pharmaceuticals, Inc. Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
US9796788B2 (en) 2010-02-08 2017-10-24 Regeneron Pharmaceuticals, Inc. Mice expressing a limited immunoglobulin light chain repertoire
US20120021409A1 (en) 2010-02-08 2012-01-26 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
BR122014002928A2 (pt) 2010-02-08 2015-12-29 Regeneron Pharma métodos de produzir um camundongo e um anticorpo e de selecionar uma região variável de cadeia pesada humana para a produção de uma proteína de ligação ao antígeno, uso de um camundongo geneticamente modificado na produção de uma proteína de ligação ao antígeno, bem como anticorpo quimérico e hibridoma
US20130185821A1 (en) 2010-02-08 2013-07-18 Regeneron Pharmaceuticals, Inc. Common Light Chain Mouse
EP2569337A1 (fr) 2010-05-14 2013-03-20 Rinat Neuroscience Corp. Protéines hétérodimériques et leurs procédés de production et de purification
NZ605966A (en) 2010-06-17 2015-04-24 Kymab Ltd Animal models and therapeutic molecules
BR122020013427B1 (pt) 2010-06-22 2021-08-03 Regeneron Pharmaceuticals, Inc Método para fazer um camundongo, uma célula ou tecido derivado de um camundongo e um hibridoma
MX363084B (es) 2010-08-02 2019-03-07 Regeneron Pharma Ratones que producen proteinas de union que comprenden dominios vl.
CN103429746B (zh) 2011-02-25 2016-05-11 瑞泽恩制药公司 Adam6小鼠
SG2014007686A (en) 2011-08-05 2014-03-28 Regeneron Pharma Humanized universal light chain mice
CA2791109C (fr) 2011-09-26 2021-02-16 Merus B.V. Generation de molecules de liaison
EP4074833A1 (fr) 2011-10-17 2022-10-19 Regeneron Pharmaceuticals, Inc. Souris à chaîne lourde d'immunoglobuline limitée
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
SG11201405088QA (en) 2012-03-06 2014-11-27 Regeneron Pharma Common light chain mouse
WO2013157953A1 (fr) 2012-04-20 2013-10-24 Merus B.V. Procédés et moyens de production de molécules de type ig
JP2015525071A (ja) 2012-06-05 2015-09-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 共通の軽鎖を用いて完全ヒト型二重特異性抗体を作製するための方法
BR112015022034B1 (pt) 2013-03-13 2023-02-28 Regeneron Pharmaceuticals, Inc Método de fabricar um camundongo, e, para fabricar um anticorpo
CN105189545A (zh) 2013-03-13 2015-12-23 瑞泽恩制药公司 常见轻链小鼠

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