SE9900030D0 - Reaction monitoring - Google Patents

Reaction monitoring

Info

Publication number
SE9900030D0
SE9900030D0 SE9900030A SE9900030A SE9900030D0 SE 9900030 D0 SE9900030 D0 SE 9900030D0 SE 9900030 A SE9900030 A SE 9900030A SE 9900030 A SE9900030 A SE 9900030A SE 9900030 D0 SE9900030 D0 SE 9900030D0
Authority
SE
Sweden
Prior art keywords
reaction
basis
data analysis
raman spectrum
solution
Prior art date
Application number
SE9900030A
Other languages
Swedish (sv)
Inventor
Mats Josefsson
Frans Langkilde
Olof Svensson
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9900030A priority Critical patent/SE9900030D0/en
Publication of SE9900030D0 publication Critical patent/SE9900030D0/en
Priority to AU21371/00A priority patent/AU758733B2/en
Priority to NZ512434A priority patent/NZ512434A/en
Priority to CA002354459A priority patent/CA2354459A1/en
Priority to EP99965685A priority patent/EP1147401A1/en
Priority to CN99815392A priority patent/CN1332844A/en
Priority to PCT/SE1999/002473 priority patent/WO2000040950A1/en
Priority to KR1020017008496A priority patent/KR20010101371A/en
Priority to JP2000592619A priority patent/JP2002534674A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/651—Cuvettes therefore
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe

Abstract

This invention relates to a method for monitoring a chemical reaction of pharmaceutical relevance, comprising the steps of: consecutively obtaining Raman spectrum samples of a solution of chemical constituents contained within a reaction vessel, by irradiating, with substantially monochromatic radiation, said solution and detecting the scattered radiation; processing said Raman spectrum samples by means of a multivariate data analysis (MVDA) for consecutively generating at least a first main component related to a latent variable indicative of the progress of the reaction wherein the multivariate data analysis is independent from calibration using reference measurements of objects having a known composition; and determining the extent of the chemical reaction on basis of said at least a first main component and optionally on basis of additionally one or more main components generated from one or more previously run reactions of the same kind.
SE9900030A 1999-01-05 1999-01-05 Reaction monitoring SE9900030D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE9900030A SE9900030D0 (en) 1999-01-05 1999-01-05 Reaction monitoring
AU21371/00A AU758733B2 (en) 1999-01-05 1999-12-22 Reaction monitoring
NZ512434A NZ512434A (en) 1999-01-05 1999-12-22 Reaction monitoring
CA002354459A CA2354459A1 (en) 1999-01-05 1999-12-22 Reaction monitoring
EP99965685A EP1147401A1 (en) 1999-01-05 1999-12-22 Reaction monitoring
CN99815392A CN1332844A (en) 1999-01-05 1999-12-22 Reaction monitoring
PCT/SE1999/002473 WO2000040950A1 (en) 1999-01-05 1999-12-22 Reaction monitoring
KR1020017008496A KR20010101371A (en) 1999-01-05 1999-12-22 Reaction monitoring
JP2000592619A JP2002534674A (en) 1999-01-05 1999-12-22 Reaction monitoring

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9900030A SE9900030D0 (en) 1999-01-05 1999-01-05 Reaction monitoring

Publications (1)

Publication Number Publication Date
SE9900030D0 true SE9900030D0 (en) 1999-01-05

Family

ID=20414039

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9900030A SE9900030D0 (en) 1999-01-05 1999-01-05 Reaction monitoring

Country Status (9)

Country Link
EP (1) EP1147401A1 (en)
JP (1) JP2002534674A (en)
KR (1) KR20010101371A (en)
CN (1) CN1332844A (en)
AU (1) AU758733B2 (en)
CA (1) CA2354459A1 (en)
NZ (1) NZ512434A (en)
SE (1) SE9900030D0 (en)
WO (1) WO2000040950A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141769B2 (en) * 2005-04-01 2006-11-28 Cem Corporation Spectroscopy-based real-time control for microwave-assisted chemistry
MX2013003038A (en) * 2010-09-17 2013-05-01 Abbvie Inc Raman spectroscopy for bioprocess operations.
US9086383B2 (en) * 2012-09-14 2015-07-21 Halliburton Energy Services, Inc. Systems and methods for monitoring chemical processes
CN103196864B (en) * 2013-04-12 2015-07-08 西北大学 Method of researching reaction mechanism by utilizing MCR-ALS (Multivariate Curve Resolution-Alternating Least Squares) combined with infrared online spectrum
EP3087516B1 (en) * 2013-12-27 2018-11-07 F.Hoffmann-La Roche Ag Method and system for preparing synthetic multicomponent biotechnological and chemical process samples
CN105548141A (en) * 2016-01-22 2016-05-04 中国科学院城市环境研究所 Method for online monitoring of pollutants in water
CN106568728A (en) * 2016-06-30 2017-04-19 华南理工大学 Method for rapidly and accurately judging pulp xanthation reaction endpoint

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5638172A (en) * 1994-05-27 1997-06-10 Eastman Chemical Company On-line quantitative analysis of chemical compositions by raman spectrometry
AU3831195A (en) * 1994-09-28 1996-04-19 Exxon Chemical Patents Inc. A method for controlling polyol ester conversion using near or mid-infrared analysis
US5596196A (en) * 1995-05-24 1997-01-21 Ashland Inc. Oxygenate analysis and control by Raman spectroscopy
US5796476A (en) * 1995-06-28 1998-08-18 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of optically measuring component in solution
US5610836A (en) * 1996-01-31 1997-03-11 Eastman Chemical Company Process to use multivariate signal responses to analyze a sample
DE19810917A1 (en) * 1998-03-13 1999-09-16 Buehler Ag Calibration method used in evaluation of measured spectra

Also Published As

Publication number Publication date
CA2354459A1 (en) 2000-07-13
JP2002534674A (en) 2002-10-15
KR20010101371A (en) 2001-11-14
EP1147401A1 (en) 2001-10-24
NZ512434A (en) 2003-12-19
CN1332844A (en) 2002-01-23
WO2000040950A1 (en) 2000-07-13
AU758733B2 (en) 2003-03-27
AU2137100A (en) 2000-07-24

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