SE9801695D0 - Inhibition of p53 function by a p53-derived peptide - Google Patents

Inhibition of p53 function by a p53-derived peptide

Info

Publication number
SE9801695D0
SE9801695D0 SE9801695A SE9801695A SE9801695D0 SE 9801695 D0 SE9801695 D0 SE 9801695D0 SE 9801695 A SE9801695 A SE 9801695A SE 9801695 A SE9801695 A SE 9801695A SE 9801695 D0 SE9801695 D0 SE 9801695D0
Authority
SE
Sweden
Prior art keywords
function
substance
inhibition
dna binding
derived peptide
Prior art date
Application number
SE9801695A
Other languages
Swedish (sv)
Inventor
Klas Wiman
Galina Selivanova
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE9801695A priority Critical patent/SE9801695D0/en
Publication of SE9801695D0 publication Critical patent/SE9801695D0/en
Priority to PCT/SE1999/000807 priority patent/WO1999058566A1/en
Priority to AU45394/99A priority patent/AU4539499A/en

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a substance which has the property of inhibiting the sequence specific DNA binding activity of p53, said substance being based on the fragment of the DNA binding core domain of p53. The substance is shown to inhibit p53 DNA binding in vitro and transactivation function in living cells. The invention includes the use of these substances, and in screening for mimetics.
SE9801695A 1998-05-14 1998-05-14 Inhibition of p53 function by a p53-derived peptide SE9801695D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9801695A SE9801695D0 (en) 1998-05-14 1998-05-14 Inhibition of p53 function by a p53-derived peptide
PCT/SE1999/000807 WO1999058566A1 (en) 1998-05-14 1999-05-12 INHIBITION OF p53 FUNCTION BY A p53-DERIVED SUBSTANCE
AU45394/99A AU4539499A (en) 1998-05-14 1999-05-12 Inhibition of p53 function by a p53-derived substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9801695A SE9801695D0 (en) 1998-05-14 1998-05-14 Inhibition of p53 function by a p53-derived peptide

Publications (1)

Publication Number Publication Date
SE9801695D0 true SE9801695D0 (en) 1998-05-14

Family

ID=20411312

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9801695A SE9801695D0 (en) 1998-05-14 1998-05-14 Inhibition of p53 function by a p53-derived peptide

Country Status (3)

Country Link
AU (1) AU4539499A (en)
SE (1) SE9801695D0 (en)
WO (1) WO1999058566A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014144A2 (en) * 2001-08-10 2003-02-20 Medical Research Council Molecule

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE183514T1 (en) * 1992-05-26 1999-09-15 Univ Leiden HUMAN PROTEIN P53 PEPTIDES FOR USE IN HUMAN CYTOTOXIC T CELL RESPONSE-INDUCING COMPOSITIONS AND HUMAN P53 PROTEIN SPECIFIC T LYMPHOCYTES
US5659024A (en) * 1994-01-14 1997-08-19 The Burnham Institute Promotors that regulate the expression of genes involved in cell death
AU4394697A (en) * 1996-08-13 1998-03-06 Trustees Of Princeton University, The P53 mutant
CA2183900A1 (en) * 1996-08-22 1998-02-23 Rick E. Preddie Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans

Also Published As

Publication number Publication date
AU4539499A (en) 1999-11-29
WO1999058566A1 (en) 1999-11-18

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