SE9801695D0 - Inhibition of p53 function by a p53-derived peptide - Google Patents
Inhibition of p53 function by a p53-derived peptideInfo
- Publication number
- SE9801695D0 SE9801695D0 SE9801695A SE9801695A SE9801695D0 SE 9801695 D0 SE9801695 D0 SE 9801695D0 SE 9801695 A SE9801695 A SE 9801695A SE 9801695 A SE9801695 A SE 9801695A SE 9801695 D0 SE9801695 D0 SE 9801695D0
- Authority
- SE
- Sweden
- Prior art keywords
- function
- substance
- inhibition
- dna binding
- derived peptide
- Prior art date
Links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention provides a substance which has the property of inhibiting the sequence specific DNA binding activity of p53, said substance being based on the fragment of the DNA binding core domain of p53. The substance is shown to inhibit p53 DNA binding in vitro and transactivation function in living cells. The invention includes the use of these substances, and in screening for mimetics.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9801695A SE9801695D0 (en) | 1998-05-14 | 1998-05-14 | Inhibition of p53 function by a p53-derived peptide |
PCT/SE1999/000807 WO1999058566A1 (en) | 1998-05-14 | 1999-05-12 | INHIBITION OF p53 FUNCTION BY A p53-DERIVED SUBSTANCE |
AU45394/99A AU4539499A (en) | 1998-05-14 | 1999-05-12 | Inhibition of p53 function by a p53-derived substance |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9801695A SE9801695D0 (en) | 1998-05-14 | 1998-05-14 | Inhibition of p53 function by a p53-derived peptide |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9801695D0 true SE9801695D0 (en) | 1998-05-14 |
Family
ID=20411312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9801695A SE9801695D0 (en) | 1998-05-14 | 1998-05-14 | Inhibition of p53 function by a p53-derived peptide |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU4539499A (en) |
SE (1) | SE9801695D0 (en) |
WO (1) | WO1999058566A1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003014144A2 (en) * | 2001-08-10 | 2003-02-20 | Medical Research Council | Molecule |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE183514T1 (en) * | 1992-05-26 | 1999-09-15 | Univ Leiden | HUMAN PROTEIN P53 PEPTIDES FOR USE IN HUMAN CYTOTOXIC T CELL RESPONSE-INDUCING COMPOSITIONS AND HUMAN P53 PROTEIN SPECIFIC T LYMPHOCYTES |
US5659024A (en) * | 1994-01-14 | 1997-08-19 | The Burnham Institute | Promotors that regulate the expression of genes involved in cell death |
AU4394697A (en) * | 1996-08-13 | 1998-03-06 | Trustees Of Princeton University, The | P53 mutant |
CA2183900A1 (en) * | 1996-08-22 | 1998-02-23 | Rick E. Preddie | Agents for the pre-symptomatic detection, prevention and treatment of breast cancer in humans |
-
1998
- 1998-05-14 SE SE9801695A patent/SE9801695D0/en unknown
-
1999
- 1999-05-12 AU AU45394/99A patent/AU4539499A/en not_active Abandoned
- 1999-05-12 WO PCT/SE1999/000807 patent/WO1999058566A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AU4539499A (en) | 1999-11-29 |
WO1999058566A1 (en) | 1999-11-18 |
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