SE8804629A - - Google Patents

Info

Publication number
SE8804629A
SE8804629A SE8804629A SE8804629A SE8804629A SE 8804629 A SE8804629 A SE 8804629A SE 8804629 A SE8804629 A SE 8804629A SE 8804629 A SE8804629 A SE 8804629A SE 8804629 A SE8804629 A SE 8804629A
Authority
SE
Sweden
Prior art keywords
compound
cyclopropylmethoxy
sulfinyl
benzimidazole
pyridinyl
Prior art date
Application number
SE8804629A
Other versions
SE8804629D0 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to SE8804629A priority Critical patent/SE8804629D0/en
Publication of SE8804629D0 publication Critical patent/SE8804629D0/en
Publication of SE8804629A publication Critical patent/SE8804629A/xx
Priority claimed from IE405089A external-priority patent/IE64199B1/en
Priority claimed from NO912415A external-priority patent/NO178337C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms

Abstract

The novel compound 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridinyl) methyl]sulfinyl]-1H-benzimidazole and physiologically acceptable salts thereof as well as intermediates, pharmaceutical compositions containing the compound as active ingredient, and the use of the compound in medicine.
SE8804629A 1988-12-22 1988-12-22 New therapeutically active compounds SE8804629D0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8804629A SE8804629D0 (en) 1988-12-22 1988-12-22 New therapeutically active compounds

Applications Claiming Priority (69)

Application Number Priority Date Filing Date Title
SE8804629A SE8804629D0 (en) 1988-12-22 1988-12-22 New therapeutically active compounds
AR31570589A AR248136A1 (en) 1988-12-22 1989-12-18 PROCEDURE AND INTERMEDIARIES FOR THE PREPARATION OF 5- FLUOR-2-ii (4-CYCLOPROPYLMETHOXY-2-PYRIDINYL) METHYLSULPHINYL-1H-BENZIMIDAZOLE (COMPOUND I)
IE405089A IE64199B1 (en) 1988-12-22 1989-12-18 Compound with gastric acid inhibitory effect and process for its preparation
EG61989A EG19302A (en) 1988-12-22 1989-12-18 Compound with gastric acid inhibitory effect and process for its preparation
IE404889A IE894048L (en) 1988-12-22 1989-12-18 New therapeutically active compound and a process for its¹preparation
EG62189A EG19303A (en) 1988-12-22 1989-12-18 Process for preparing of new therapeutically active compound
PH39732A PH27400A (en) 1988-12-22 1989-12-19 New therapeutically active compound and method of use thereof
CA 2005980 CA2005980C (en) 1988-12-22 1989-12-19 Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation
IL9279989A IL92799A (en) 1988-12-22 1989-12-19 Benzimidazole derivative, process for its preparation, and pharmaceutical compositions for inhibiting gastric acid secretion containing it
IL9279889A IL92798D0 (en) 1988-12-22 1989-12-19 Benzimidazole derivatives,process for their preparation and pharmaceutical compositions containing them
NZ23187289A NZ231872A (en) 1988-12-22 1989-12-19 5-fluoro-2-(((4-cyclopropylmethoxy-2-pyridinyl)methyl)sulphinyl)-1h-benzimidazole, various pyridine intermediates and pharmaceutical compositions
CA002005986A CA2005986C (en) 1988-12-22 1989-12-19 Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation
GR890100833A GR1000316B (en) 1988-12-22 1989-12-19 Process for the preparation of a compound with gastric inhibitopy effect
GR89100838A GR1002252B (en) 1988-12-22 1989-12-19 A novel therapeutic active compound and preparation method therefore.
NZ23187489A NZ231874A (en) 1988-12-22 1989-12-19 4-fluoro-2-(((4-methoxy-2-pyridinyl)methyl)sulphinyl)-1h-benzimidazole and pharmaceutical compositions
PH39731A PH27446A (en) 1988-12-22 1989-12-19 Compound with gastric acid inhibitory effect
SU4895789 RU2073676C1 (en) 1988-12-22 1989-12-20 5-fluoro-2-{[(4-cyclopropylmethoxy-2-pyridinyl)methyl]sulfinyl}-1h-benzimidazole or its physiologically acceptable salt, pharmcomposition based on thereof and intermediate compounds
JP2501536A JP2793905B2 (en) 1988-12-22 1989-12-20 The compounds and their preparation having gastric acid inhibiting effect
DD33598189A DD296079A5 (en) 1988-12-22 1989-12-20 Process for the preparation of benzimidazolene
DE1989617937 DE68917937T2 (en) 1988-12-22 1989-12-20 Compounds with gastric inhibitory effect and process for preparing.
DE1989624273 DE68924273T2 (en) 1988-12-22 1989-12-20 Therapeutically active compound and processes for their preparation.
JP2501537A JP2793906B2 (en) 1988-12-22 1989-12-20 Therapeutically active novel compounds and their preparation
HU109589A HUT57204A (en) 1988-12-22 1989-12-20 Process for producing 4-fluoro-2-///4-methoxy-2-pyridinyl/-methyl/-sulfinyl/-1h-benzimidazol with gastric acid secration-diminishing activity and pharmaceutical compositions containing them
US07/454,047 US5008278A (en) 1988-12-22 1989-12-20 Therapeutically active compound and a process for its preparation
ZA899794A ZA8909794B (en) 1988-12-22 1989-12-20 New therapeutically active compound and a process for its preparation
HU901095A HU205927B (en) 1988-12-22 1989-12-20 Process for producing 4-fluoro-2-///4-methoxy-2-piridinyl/-sulfinyl/-1h-benzimidazol of acid secretion inhibiting activity and pharmaceutical compositions containing them
DD33598089A DD296078A5 (en) 1988-12-22 1989-12-20 Process for the preparation of benzimidazolene
DE1989617937 DE68917937D1 (en) 1988-12-22 1989-12-20 Compounds with gastric inhibitory effect and process for preparing.
HU108489A HU205926B (en) 1988-12-22 1989-12-20 Process for producing new, pharmaceutically active 5-fluoro-2- 4-/cyclopropyl-methoxy/-2-pyridinyl-methyl-sulfinyl-1h-benzimidazol and pharmaceutical compositions containing them
KR1019900701827A KR910700248A (en) 1988-12-22 1989-12-20 Method of producing the compound, and has a gastric acid secretion inhibiting effect
EP19900901079 EP0449940B1 (en) 1988-12-22 1989-12-20 New therapeutically active compound and a process for its preparation
PCT/SE1989/000739 WO1990006924A1 (en) 1988-12-22 1989-12-20 Compound with gastric acid inhibitory effect and process for its preparation
AU48175/90A AU634741B2 (en) 1988-12-22 1989-12-20 Benzimidazole and (4-cyclopropyl methoxy pyridinyl) linked derivatives
US07/453,960 US5025024A (en) 1988-12-22 1989-12-20 Therapeutically active fluoro-substituted compound
AT90901073T AT110723T (en) 1988-12-22 1989-12-20 Compounds with gastric inhibitory effect and process for preparing.
RO14786689A RO110494B1 (en) 1988-12-22 1989-12-20 New therapeutic compounds and preparation process therefor
KR1019900701828A KR917000249A (en) 1988-12-22 1989-12-20 New therapeutically active compounds, and a method of producing
AT90901079T AT127799T (en) 1988-12-22 1989-12-20 Therapeutically active compound and processes for their preparation.
DE1989624273 DE68924273D1 (en) 1988-12-22 1989-12-20 Therapeutically active compound and processes for their preparation.
PCT/SE1989/000740 WO1990006925A1 (en) 1988-12-22 1989-12-20 New therapeutically active compound and a process for its preparation
EP19900901073 EP0449935B1 (en) 1988-12-22 1989-12-20 Compound with gastric acid inhibitory effect and process for its preparation
ZA899795A ZA8909795B (en) 1988-12-22 1989-12-20 Compound with gastric acid inhibitory effect and process for its preparation
AU48132/90A AU639429B2 (en) 1988-12-22 1989-12-20 Compound with gastric acid inhibitory effect and process for its preparation
PT9264889A PT92648B (en) 1988-12-22 1989-12-21 5-fluoro-2 - ({4-cyclopopyl methoxy-2-pyridinyl) -methyl} sulfinyl) -1h-benzimidazole and of pharmaceutical compositions containing it
MYPI8901835 MY129946A (en) 1988-12-22 1989-12-21 Compound with gastric acid inhibitory effect and process for its preparation.
YU242689A YU46806B (en) 1988-12-22 1989-12-21 5-fluoro-2 - // (4-cyclopropylmethoxy-2-PIRINIDIL) methylsulfinyl / 1h-BENZIMODAZOL and a process for making
YU242789A YU47338B (en) 1988-12-22 1989-12-21 The new compound 4-fluoro-2 - // (4-methoxy-2-pyridinyl) methyl / sulfinyl / - benzimidazole-1h and the process for preparing
CN 89109587 CN1028231C (en) 1988-12-22 1989-12-21 Therapeutically active compound and process for preparation
PT9264989A PT92649B (en) 1988-12-22 1989-12-21 Method for the preparation of 4-fluoro-2 - ({4-methoxy-2-pyridinyl) -methyl} sulfinyl) -1h-benzimidazole and of pharmaceutical compositions containing it
CN 89109589 CN1028233C (en) 1988-12-22 1989-12-21 Compound with gastric acid inhibitory effect and process for preparation
PL28292289A PL160767B1 (en) 1988-12-22 1989-12-22 Method for manufacturing new 4-fluoro-2-((4-methoxypyridinilo-2) methylsulphynyl)-1h-benzimidazole
CS897343A CS276361B6 (en) 1988-12-22 1989-12-22 4-fluoro-2-//(4-methoxy-2-pyridyl)methyl/sulfinyl/ -1h - benzimidazole, process for its production and a pharmaceutical comprising said compound as an active component
PL28292389A PL161150B1 (en) 1988-12-22 1989-12-22 Method for manufacturing new 5-fluoro-2-((4-cyclopropylmethoxy-pyridinilo-2) methylsulphynyl)-1h-benzimidazole
US07/633,007 US5039808A (en) 1988-12-22 1990-12-20 Therapeutically active cyclopropyl substituted compound
BG9465791A BG60101A3 (en) 1988-12-22 1991-06-19 Method for preparing of 4-fluoro-2-[[(4-methoxy-2-pyridinyl)methyl]thionil]-1h-benzimidazo le
BG9465991A BG60102A3 (en) 1988-12-22 1991-06-19 Method for preparing of 5-fluoro-2[[(4-cyclopropylmethoxy-2-pyridyl)methyl]thionyl]-1h-ben zimidazole
FI913034A FI913034A0 (en) 1988-12-22 1991-06-20 Foerening with magsyrainhiberande effect can foerfarande Foer och dess framstaellning.
FI913035A FI913035A0 (en) 1988-12-22 1991-06-20 Ny terapeutiskt of active foerening och dess foerfarande Foer framstaellning.
NO912415A NO178337C (en) 1988-12-22 1991-06-20 A process for the preparation of therapeutically active 5-fluoro-2 [[(4-cyclopropyl- (methoxy-2-pyridinyl) metylÅsulfinylÅ-1H-benzimidazole and intermediates
NO912414A NO178336C (en) 1988-12-22 1991-06-20 A process for the preparation of a therapeutically active benzimidazole compound and intermediates
SU4895805 RU2042673C1 (en) 1988-12-22 1991-06-21 4-fluoro-2-{[ (4-methoxy- 2-pyridinyl)methyl]sulfinyl} -1h-benzi- midazole or its physiologically acceptable salts, method of their synthesis, and pharmaceutical composition of 4-fluoro -2-mercapto-1h- benzimidazole and 4-fluoro -2-{[(4- methoxy-2-pyridinyl) methyl]thio}-1h -benzimidazole
DK122191A DK122191A (en) 1988-12-22 1991-06-21 Benzimidazole derivative and physiologically acceptable salts thereof and processes for preparing the same
DK122291A DK170800B1 (en) 1988-12-22 1991-06-21 Substituted benzimidazole derivative and physiologically acceptable salts and optical enantiomers, and its method of making the same, pharmaceutical composition containing the derivative, the use of the derivative for the manufacture of a medicament for the inhibition of gastric acid secretion in mammals and for the treatment of inflammatory gastrointestinal tract disorders in mammals as well as intermediate compounds for
HRP920831 HRP920831A2 (en) 1988-12-22 1992-10-02 New therapeutically active compound and a process for the preparation eof
LV930691A LV10267B (en) 1988-12-22 1993-06-28 Compound with gastric acid inhibitory effect and process for its preparation
LV930860A LV10187B (en) 1988-12-22 1993-06-30 New therapeutically active compound and a process for its preparation
LTIP1726A LT3914B (en) 1988-12-22 1993-12-30 Compound with gastric acid inhibitory effect and process for its preparation
LTIP1721A LT3980B (en) 1988-12-22 1993-12-30 New therapeutically active compound and a process for its preparation
FI954768A FI954768A0 (en) 1988-12-22 1995-10-06 Useful as intermediates 4-syklopropyylimetoksipyridiiniyhdisteet

Publications (2)

Publication Number Publication Date
SE8804629D0 SE8804629D0 (en) 1988-12-22
SE8804629A true SE8804629A (en) 1988-12-22

Family

ID=20374310

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8804629A SE8804629D0 (en) 1988-12-22 1988-12-22 New therapeutically active compounds

Country Status (32)

Country Link
US (2) US5008278A (en)
EP (1) EP0449940B1 (en)
JP (1) JP2793906B2 (en)
KR (1) KR917000249A (en)
CN (1) CN1028231C (en)
AR (1) AR248136A1 (en)
AT (1) AT127799T (en)
AU (1) AU634741B2 (en)
BG (1) BG60102A3 (en)
CA (1) CA2005986C (en)
DD (2) DD296078A5 (en)
DE (2) DE68924273D1 (en)
DK (1) DK170800B1 (en)
EG (1) EG19303A (en)
FI (2) FI913035A0 (en)
GR (1) GR1002252B (en)
HR (1) HRP920831A2 (en)
HU (2) HU205927B (en)
IE (1) IE894048L (en)
IL (1) IL92798D0 (en)
LT (2) LT3980B (en)
LV (1) LV10187B (en)
NZ (1) NZ231872A (en)
PH (1) PH27400A (en)
PL (1) PL161150B1 (en)
PT (1) PT92648B (en)
RO (1) RO110494B1 (en)
RU (2) RU2073676C1 (en)
SE (1) SE8804629D0 (en)
WO (1) WO1990006925A1 (en)
YU (1) YU46806B (en)
ZA (2) ZA8909794B (en)

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Also Published As

Publication number Publication date
EP0449940B1 (en) 1995-09-13
YU242689A (en) 1991-04-30
LT3914B (en) 1996-04-25
FI954768A0 (en) 1995-10-06
ZA8909794B (en) 1990-08-29
AT127799T (en) 1995-09-15
DK122291D0 (en) 1991-06-21
PH27400A (en) 1993-06-21
JP2793906B2 (en) 1998-09-03
RU2042673C1 (en) 1995-08-27
US5008278A (en) 1991-04-16
IL92798D0 (en) 1990-09-17
CN1043713A (en) 1990-07-11
HRP920831A2 (en) 1995-12-31
LTIP1726A (en) 1995-07-25
GR890100838A (en) 1991-03-15
DK170800B1 (en) 1996-01-22
AU4817590A (en) 1990-07-10
PT92648A (en) 1990-06-29
YU46806B (en) 1994-06-10
PT92648B (en) 1995-09-12
LTIP1721A (en) 1995-07-25
ZA8909795B (en) 1990-08-29
CA2005986C (en) 1999-08-03
DK122291A (en) 1991-06-24
LV10187B (en) 1995-04-20
DE68924273D1 (en) 1995-10-19
US5039808A (en) 1991-08-13
RU2073676C1 (en) 1997-02-20
KR917000249A (en) 1991-03-14
AU634741B2 (en) 1993-03-04
FI913035D0 (en)
DD296079A5 (en) 1991-11-21
FI913035A0 (en) 1991-06-20
FI954768A (en) 1995-10-06
RO110494B1 (en) 1996-01-30
CN1028231C (en) 1995-04-19
HU205927B (en) 1992-07-28
DD296078A5 (en) 1991-11-21
AR248136A1 (en) 1995-06-30
EP0449940A1 (en) 1991-10-09
JPH04502461A (en) 1992-05-07
LT3980B (en) 1996-06-25
DE68924273T2 (en) 1996-02-15
HUT57202A (en) 1991-11-28
NZ231872A (en) 1992-03-26
WO1990006925A1 (en) 1990-06-28
PL161150B1 (en) 1993-05-31
IE894048L (en) 1990-06-22
BG60102A3 (en) 1993-10-15
HU205926B (en) 1992-07-28
SE8804629D0 (en) 1988-12-22
HU901084D0 (en) 1991-09-30
EG19303A (en) 1994-11-30
GR1002252B (en) 1996-04-23
CA2005986A1 (en) 1990-06-22
LV10187A (en) 1994-10-20

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