SE8403488D0 - PHARMACEUTICAL COMPOSITION - Google Patents
PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- SE8403488D0 SE8403488D0 SE8403488A SE8403488A SE8403488D0 SE 8403488 D0 SE8403488 D0 SE 8403488D0 SE 8403488 A SE8403488 A SE 8403488A SE 8403488 A SE8403488 A SE 8403488A SE 8403488 D0 SE8403488 D0 SE 8403488D0
- Authority
- SE
- Sweden
- Prior art keywords
- diol
- alkyl
- ester
- weight
- pyrrolidone
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A pharmaceutical composition for administration to the skin comprises a pharmaceutical agent, such as a benzodiazepine, and a percutaneous carrier liquid comprising: (A) a compound melting at below 38 DEG C which is a C5-24 aliphatic hydrocarbon optionally halo- substituted, a C7-18 ester of an aliphatic carboxylic acid, a C10-18 ether, a C11-15 ketone, or a 10- 26C aliphatic monoalcohol which may be unsaturated or cyclic, provided that if it is 14-26C it has at least one unsaturation, branched chain and/or alicyclic group; (B) a thioglycerol, lactic acid or ester, cyclic urea, alkyl or acyl urea, alkyl amide and/or pyrrolidone or N- alkyl pyrrolidone; and (C) a diol, preferably C3-8. The weight of (A) is 0.1-80% of (A)+(B); the weight of the pharmaceutical agent is 0.01 to 50% of (A)+(B); the diol (C) is preferably 10-100 wt% of (B). The diol (C) reduces the effect of (A) and (B). Other components or vehicles can be present. The agent is rapidly absorbed through the skin of a mammal to which the composition is applied.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51010083A | 1983-07-01 | 1983-07-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8403488D0 true SE8403488D0 (en) | 1984-06-29 |
| SE8403488L SE8403488L (en) | 1985-01-02 |
Family
ID=24029385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8403488A SE8403488L (en) | 1983-07-01 | 1984-06-29 | PHARMACEUTICAL COMPOSITION |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS6013720A (en) |
| CA (1) | CA1227753A (en) |
| CH (1) | CH658993A5 (en) |
| DE (1) | DE3424058C3 (en) |
| DK (1) | DK315984A (en) |
| FR (1) | FR2548024B1 (en) |
| GB (1) | GB2142238B (en) |
| NL (1) | NL8402045A (en) |
| SE (1) | SE8403488L (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60199822A (en) * | 1984-03-23 | 1985-10-09 | Takeda Chem Ind Ltd | External pharmaceutical for percutaneous absorption |
| DE4209862A1 (en) * | 1992-03-26 | 1993-09-30 | Linde Ag | Pallet truck |
| US5693335A (en) * | 1995-06-07 | 1997-12-02 | Cygnus, Inc. | Skin permeation enhancer composition for use with sex steroids |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL281225A (en) * | 1961-07-20 | |||
| FR2001768A1 (en) * | 1968-02-12 | 1969-10-03 | Gillette Co | N-Alkyl-2-pyrrolidone to improve cutaneous absorption - methyl, ethyl and n-butyl pyrrolidone(s), opt. with water and/or ethanol give improved skin penetration |
| SE325667B (en) * | 1968-03-06 | 1970-07-06 | Medisan Ab | |
| US3551554A (en) * | 1968-08-16 | 1970-12-29 | Crown Zellerbach Corp | Enhancing tissue penetration of physiologically active agents with dmso |
| US3472931A (en) * | 1969-01-17 | 1969-10-14 | Foster Milburn Co | Percutaneous absorption with lower alkyl amides |
| GB1404583A (en) * | 1971-10-08 | 1975-09-03 | Vymatt Sa | Urea compositions and methods of preparation thereof |
| DE2528516A1 (en) * | 1974-07-05 | 1976-01-22 | Sandoz Ag | NEW GALENIC PREPARATION |
| GB1504302A (en) * | 1974-08-23 | 1978-03-15 | Fisons Ltd | Sedative method and composition |
| US3969516A (en) * | 1974-12-19 | 1976-07-13 | Nelson Research & Development Company | Composition and method for treatment of acne |
| US4017641A (en) * | 1975-01-31 | 1977-04-12 | The Procter & Gamble Company | Skin moisturizing compositions containing 2-pyrrolidinone |
| GB1538903A (en) * | 1975-04-11 | 1979-01-24 | Nelson Res & Dev | Carrier for a topically applied physiologically active agent or cosmetic agent |
| GB1553310A (en) * | 1975-06-19 | 1979-09-26 | Nelson Res & Dev | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
| DE2608221B1 (en) * | 1976-02-28 | 1977-07-21 | Beiersdorf Ag | COSMETIC AGENT FOR SMOOTHING THE SKIN |
| JPS52148614A (en) * | 1976-06-04 | 1977-12-10 | Masao Yonemushi | Production of additive for skin medicine |
| US4202888A (en) * | 1976-07-12 | 1980-05-13 | Kali-Chemie Pharma Gmbh. | Readily enterally absorbable pharmaceutical compositions of cardiac glycosides and preparation thereof |
| EP0006724B1 (en) * | 1978-06-16 | 1982-12-01 | Phares Pharmaceutical Research N.V. | Pharmaceutical compositions containing urea |
| DE2847975A1 (en) * | 1978-11-04 | 1980-05-14 | Merck Patent Gmbh | Free formaldehyde removal from pharmaceuticals and cosmetics - by adding urea to bind the formaldehyde |
| CA1165240A (en) * | 1980-07-09 | 1984-04-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions |
| JPS58164520A (en) * | 1982-03-24 | 1983-09-29 | Nitto Electric Ind Co Ltd | Base composition and drug composition for external use |
-
1984
- 1984-02-20 JP JP2867084A patent/JPS6013720A/en active Granted
- 1984-06-06 CA CA000455978A patent/CA1227753A/en not_active Expired
- 1984-06-26 CH CH308384A patent/CH658993A5/en not_active IP Right Cessation
- 1984-06-27 GB GB08416358A patent/GB2142238B/en not_active Expired
- 1984-06-28 NL NL8402045A patent/NL8402045A/en not_active Application Discontinuation
- 1984-06-28 DK DK315984A patent/DK315984A/en not_active Application Discontinuation
- 1984-06-28 FR FR8410276A patent/FR2548024B1/en not_active Expired
- 1984-06-29 SE SE8403488A patent/SE8403488L/en not_active Application Discontinuation
- 1984-06-29 DE DE19843424058 patent/DE3424058C3/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1227753A (en) | 1987-10-06 |
| FR2548024B1 (en) | 1988-04-29 |
| GB8416358D0 (en) | 1984-08-01 |
| DE3424058C3 (en) | 1992-05-07 |
| SE8403488L (en) | 1985-01-02 |
| DE3424058A1 (en) | 1985-01-10 |
| GB2142238A (en) | 1985-01-16 |
| JPS6013720A (en) | 1985-01-24 |
| JPH0119365B2 (en) | 1989-04-11 |
| DK315984D0 (en) | 1984-06-28 |
| FR2548024A1 (en) | 1985-01-04 |
| DK315984A (en) | 1985-01-02 |
| CH658993A5 (en) | 1986-12-31 |
| NL8402045A (en) | 1985-02-01 |
| GB2142238B (en) | 1987-04-15 |
| DE3424058C2 (en) | 1986-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8403488-3 Effective date: 19930527 |