SE8005933L - PROCEDURE FOR THE PREPARATION OF N-ALKYLERATED ORGOTEIN DERIVATIVE - Google Patents

PROCEDURE FOR THE PREPARATION OF N-ALKYLERATED ORGOTEIN DERIVATIVE

Info

Publication number
SE8005933L
SE8005933L SE8005933A SE8005933A SE8005933L SE 8005933 L SE8005933 L SE 8005933L SE 8005933 A SE8005933 A SE 8005933A SE 8005933 A SE8005933 A SE 8005933A SE 8005933 L SE8005933 L SE 8005933L
Authority
SE
Sweden
Prior art keywords
orgotein
preparation
alkylerated
derivative
procedure
Prior art date
Application number
SE8005933A
Other languages
Swedish (sv)
Inventor
W Huber
M G Saifer
L D Williams
Original Assignee
Diagnostic Data Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/611,659 external-priority patent/US4022888A/en
Priority claimed from US05/611,657 external-priority patent/US4042689A/en
Priority claimed from US05/639,076 external-priority patent/US4070459A/en
Application filed by Diagnostic Data Inc filed Critical Diagnostic Data Inc
Publication of SE8005933L publication Critical patent/SE8005933L/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Claims (1)

PatentkravPatent claims 1. Fdrfaringssdtt for fromstdllning ay injicerbara orgoteinderivat med cnti-inflammotorisk verkan, kdnnetecknat ov att man btingor oxgotein att xeogera med ett olkyleringsmedel till 6stodkommande ay ett N-alkylerat orgotein med en alkylgrupp p6 aminstone en ay orgoteinets lysin-g-aminogrupper och med den ollmdnna formeln (142N)m-Org-(NHCH2R)n i vilken n Sr ett helt tel mellon 1 och omkring 26, fdretrddesvis Otminstone 10 eller mellan 10 och 18, och summon av m och n Sr dot total ontalet titrerbata ftio aminogtoppex i den omodifierade orgoteinkongenen, och R Sr H, CH3, C2H5, n-C3H7 eller flagon annon alkyl med upp till 7 kolatomer, -COON, -COO-LA, -CONH-LA, -CON(LA)2, -CON, -C(2-C.N, -Ph, -COPh, -CH2011 ellex -CH(C113)0N, i vilket fall LA Sr en logre alkyl med mellan 1 och 4 kolatomer och Ph Sr osubstituerad fenyl eller fenyl, so 1 - 3 enkla $ 'tuenter, och Org Sr Oterstoden ov orgotei ylen.A process for the preparation of injectable orgotein derivatives having anti-inflammatory activity, characterized in that oxgotein is required to co-react with an alkylating agent to give an N-alkylated orgotein having an alkyl group on the amine group and the lysine and the formula (142N) m-Org- (NHCH2R) ni which n is an integer between 1 and about 26, preferably at least 10 or between 10 and 18, and the sum of m and n , and R is Sr H, CH 3, C 2 H 5, n-C 3 H 7 or phlogonal alkyl having up to 7 carbon atoms, -COON, -COO-LA, -CONH-LA, -CON (LA) 2, -CON, -C (2 -CN, -Ph, -COPh, -CH 2 O 11 or -CH (C113) 0N, in which case LA Sr is a crude alkyl having between 1 and 4 carbon atoms and Ph Sr is unsubstituted phenyl or phenyl, so 1 - 3 simple and Org Sr Oterstoden ov orgotei ylen.
SE8005933A 1975-09-09 1980-08-25 PROCEDURE FOR THE PREPARATION OF N-ALKYLERATED ORGOTEIN DERIVATIVE SE8005933L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/611,659 US4022888A (en) 1975-09-09 1975-09-09 Esterified orgotein
US05/611,657 US4042689A (en) 1975-09-09 1975-09-09 Alkylated orgotein
US05/639,076 US4070459A (en) 1975-12-09 1975-12-09 N-carbamylated orgotein

Publications (1)

Publication Number Publication Date
SE8005933L true SE8005933L (en) 1980-08-25

Family

ID=27417063

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7609978A SE7609978L (en) 1975-09-09 1976-09-09 PROCEDURE FOR THE PRODUCTION OF ORGOTEIN DERIVATIVES
SE8005934A SE8005934L (en) 1975-09-09 1980-08-25 PROCEDURE FOR PREPARATION OF FORESTRAT ORGOTEIN DERIVATIVE
SE8005933A SE8005933L (en) 1975-09-09 1980-08-25 PROCEDURE FOR THE PREPARATION OF N-ALKYLERATED ORGOTEIN DERIVATIVE

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7609978A SE7609978L (en) 1975-09-09 1976-09-09 PROCEDURE FOR THE PRODUCTION OF ORGOTEIN DERIVATIVES
SE8005934A SE8005934L (en) 1975-09-09 1980-08-25 PROCEDURE FOR PREPARATION OF FORESTRAT ORGOTEIN DERIVATIVE

Country Status (14)

Country Link
CA (1) CA1090782A (en)
CS (1) CS203992B2 (en)
DD (1) DD128695A5 (en)
DE (1) DE2637778A1 (en)
DK (1) DK396376A (en)
FI (1) FI57112C (en)
FR (2) FR2323395A1 (en)
GB (1) GB1561295A (en)
IE (1) IE43701B1 (en)
IL (1) IL50287A (en)
IT (1) IT1068221B (en)
NL (1) NL7610003A (en)
NO (1) NO763075L (en)
SE (3) SE7609978L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202009017709U1 (en) 2009-12-31 2011-09-02 Heinz-Dieter Matuschak Rotary valve and conveyor for conveying bulk material

Also Published As

Publication number Publication date
IT1068221B (en) 1985-03-21
GB1561295A (en) 1980-02-20
DD128695A5 (en) 1977-12-07
NO763075L (en) 1977-03-10
CS203992B2 (en) 1981-03-31
DK396376A (en) 1977-03-10
FI57112B (en) 1980-02-29
SE7609978L (en) 1977-03-10
SE8005934L (en) 1980-08-25
CA1090782A (en) 1980-12-02
IE43701L (en) 1977-03-09
FR2323395A1 (en) 1977-04-08
IL50287A (en) 1979-11-30
IL50287A0 (en) 1976-10-31
FR2362864A1 (en) 1978-03-24
NL7610003A (en) 1977-03-11
IE43701B1 (en) 1981-05-06
FR2362864B1 (en) 1981-01-16
FI57112C (en) 1980-06-10
DE2637778A1 (en) 1977-03-17
FI762566A (en) 1977-03-10
FR2323395B1 (en) 1979-06-22

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