SE7809348A - Tiazinderivat - Google Patents

Tiazinderivat

Info

Publication number
SE7809348A
SE7809348A SE7809348A SE7809348A SE7809348A SE 7809348 A SE7809348 A SE 7809348A SE 7809348 A SE7809348 A SE 7809348A SE 7809348 A SE7809348 A SE 7809348A SE 7809348 A SE7809348 A SE 7809348A
Authority
SE
Sweden
Prior art keywords
lt
gt
denotes
halogen
image
Prior art date
Application number
SE7809348A
Other languages
Swedish (sv)
Inventor
Dieter Binder
Otto Hromatka
Rudolf Dr Pfister
Paul Dr Zeller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to LU78083 priority Critical
Priority to CH790878 priority
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE7809348A publication Critical patent/SE7809348A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/34Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

Antiinflammatory, analgesic, antirheumatic and antithrombotic thienothiazine derivatives are described having the general formula <IMAGE> and salts thereof wherein <IMAGE> represents the group <IMAGE> R<1> denotes lower alkyl, R<2> denotes the radical of an aromatic heterocyclic with 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl radical optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy, R<3> denotes halogen and R<3'> denotes hydrogen or halogen, as well as processes for their preparation.
SE7809348A 1977-09-06 1978-09-05 Tiazinderivat SE7809348A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
LU78083 1977-09-06
CH790878 1978-07-21

Publications (1)

Publication Number Publication Date
SE7809348A true SE7809348A (en) 1979-03-07

Family

ID=25702440

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7809348A SE7809348A (en) 1977-09-06 1978-09-05 Tiazinderivat

Country Status (28)

Country Link
US (1) US4180662A (en)
EP (1) EP0001113B1 (en)
JP (1) JPS6149318B2 (en)
AR (1) AR222472A1 (en)
AT (1) AT364851B (en)
AU (1) AU518216B2 (en)
BR (1) BR7805845A (en)
CA (1) CA1103246A (en)
CS (1) CS202019B2 (en)
DE (2) DE2838851A1 (en)
DK (1) DK148280C (en)
ES (1) ES473074A1 (en)
FI (1) FI63587C (en)
GB (1) GB2003877B (en)
GR (1) GR73066B (en)
HK (1) HK1085A (en)
HU (1) HU176979B (en)
IE (1) IE47261B1 (en)
IL (1) IL55465A (en)
IT (1) IT1099046B (en)
LU (1) LU90207I2 (en)
MC (1) MC1212A1 (en)
NL (1) NL7809015A (en)
NO (1) NO149174C (en)
NZ (1) NZ188320A (en)
PH (1) PH13949A (en)
PT (1) PT68515A (en)
SE (1) SE7809348A (en)

Families Citing this family (43)

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DE2838377A1 (en) * 1978-09-02 1980-03-20 Thomae Gmbh Dr K New 4-hydroxy-2H bracket to 1 square bracket-shaped to benzothieno square bracket 2,3-e parenthesis -1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof, their use and processes for their production
AU5811280A (en) * 1979-06-13 1980-12-18 F. Hoffmann-La Roche Ag Thiazine derivatives
JPH0229679B2 (en) * 1981-12-22 1990-07-02 Mitsui Toatsu Chemicals
EP0103142B1 (en) * 1982-09-09 1987-04-22 F. HOFFMANN-LA ROCHE &amp; CO. Aktiengesellschaft Thieno(2,3-e)-1,2-thiazine derivatives
GR80576B (en) * 1983-10-17 1984-11-29 Fujisawa Pharmaceutical Co Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4551452A (en) * 1983-12-21 1985-11-05 Pfizer Inc. Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
DE3346526C2 (en) * 1983-12-22 1986-12-11 A. Nattermann & Cie Gmbh, 5000 Koeln, De
JPS60184077A (en) * 1984-02-23 1985-09-19 Pfizer Antiinflammatory oxime precursor drug
US4656265A (en) * 1984-06-21 1987-04-07 Pfizer Inc. Cyclic prodrugs of antiinflammatory oxicams
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
WO1988009793A1 (en) * 1987-06-10 1988-12-15 Pfizer Inc. 3,4-DIHYDRO-2-ALKYL-3-OXO-N-ARYL-2H-[1]BENZOTHIENO[3,2-e]-1,2-THIAZINE-4-CARBOXAMIDE-1,1-DIOXIDES
IL87951A (en) * 1987-10-29 1992-03-29 Chem Pharm Forsch Gmbh Carbonic acid esters of 6-chloro-4-(1-hydroxyethoxy)-2-methyl-n-(2-pyridyl)-2h-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide,their preparation and pharmaceutical compositions containing them
ATA39088A (en) 1988-02-18 1990-06-15 Binder Dieter Dr Basically substituted thienoisothiazol-3 (2H) -one-1,1-dioxide and their pharmaceutically acceptable salts, processes for their preparation and their use
AT390060B (en) * 1988-05-02 1990-03-12 Cl Pharma thiophencarbonsaeureestern 5-chloro-2-3chlorsulfonyl-process for the preparation of
JPH01316314A (en) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd Wet compress
JPH01316315A (en) * 1988-06-16 1989-12-21 Taisho Pharmaceut Co Ltd Plaster
DE4141218A1 (en) * 1991-12-13 1993-06-17 Luitpold Werk Chem Pharm Thiadiazincarbone acidamide derivatives, method for the production thereof and medicaments
AT399880B (en) * 1992-07-03 1995-08-25 Chem Pharm Forsch Gmbh New thienothiazinderivate, process for their production and their use
AT400845B (en) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh New thienothiazinderivate, a process for their production and their use
EP0658559A1 (en) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazin derivatives, process for their preparation and their use as 5-dipoxygenase and cyclooxygenase inhibitors
AT400437B (en) * 1993-12-14 1995-12-27 Chem Pharm Forsch Gmbh Novel N-heterocyclic thienothiazinecarboxamides, process for their preparation and their use
AT400568B (en) * 1994-05-18 1996-01-25 Chem Pharm Forsch Gmbh Novel N-heterocyclic thienothiazinecarboxamides, process for their preparation and their use
DE19747625A1 (en) * 1997-10-29 1999-05-06 Bayer Ag A process for the preparation of 3,5-dimethylisoxazole-4-sulphonyl chloride
IT1308633B1 (en) 1999-03-02 2002-01-09 Nicox Sa Nitrossiderivati.
DE19933260A1 (en) 1999-07-15 2001-01-18 Bayer Ag Substituted thien-3-yl-sulfonylamino (thio) carbonyl-triazolin (ethi) ones
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
SI1401825T1 (en) * 2001-06-11 2010-01-29 Virochem Pharma Inc Thiophene derivatives as antiviral agents for flavivirus infection
CN1171892C (en) * 2001-06-25 2004-10-20 晶 李 Thienothiazine compound with anti-inflammatory and antalgic activity and its preparing process and usage
KR101058696B1 (en) * 2002-12-10 2011-08-22 바이로켐 파마 인코포레이티드 Compounds and Methods for the Treatment or Prevention of Furabivirus Infections
AT413944B (en) * 2003-05-27 2006-07-15 Binder Eva Dkfm Use of oxicam compounds
CN1266155C (en) * 2003-08-01 2006-07-26 浙江震元制药有限公司 6-chloro-4-hydroxy-2-methyl-2H-thieno-(2,3-e)-1,2-thiazine-1,1-dioxide-3
DE102004010812A1 (en) * 2004-03-05 2005-09-22 Bayer Cropscience Ag Weed control methods
US8431110B2 (en) * 2005-05-23 2013-04-30 Hmi Medical Innovations, Llc. Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
AU2005247943A1 (en) * 2004-05-23 2005-12-08 Gerard M. Housey Theramutein modulators
JP5030947B2 (en) 2005-05-13 2012-09-19 ヴァイロケム・ファーマ・インコーポレーテッド Compounds and methods for the treatment and prevention of flavivirus infections
US20090275070A1 (en) * 2005-11-23 2009-11-05 Housey Gerard M Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
EP2084165B1 (en) 2006-10-11 2013-06-12 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate
EA201101492A1 (en) 2006-11-15 2012-09-28 Вирокем Фарма Инк. Tiophene analogues for the treatment or prevention of flavivirus infections
WO2008149181A1 (en) * 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
CN101314598B (en) 2008-07-14 2012-03-21 浙江工业大学 Novel synthesis process for 5-chlorine-2-carboxylic methyl ester-3-methylamino sulfuryl thiophene
CN108218895B (en) * 2018-04-13 2019-06-18 北京金城泰尔制药有限公司沧州分公司 The method of one pot process Lornoxicam intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821211A (en) * 1972-03-10 1974-06-28 Warner Lambert Co Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolycarbamoyl)-2-methyl-2h-1,2-benzothiazine 1,1-dioxide
IL47877A (en) * 1974-08-26 1978-10-31 Sparamedica Ag Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
CA1066711A (en) * 1974-08-26 1979-11-20 Hoffmann-La Roche Limited Thiophene derivatives
MC1135A1 (en) * 1976-02-23 1977-11-18 Hoffmann La Roche Thiazine derivatives

Also Published As

Publication number Publication date
IL55465D0 (en) 1978-10-31
FI782737A (en) 1979-03-07
ATA642178A (en) 1981-04-15
PT68515A (en) 1978-10-01
JPS6149318B2 (en) 1986-10-29
FI63587C (en) 1983-07-11
MC1212A1 (en) 1979-05-18
AR222472A1 (en) 1981-05-29
HU176979B (en) 1981-06-28
DK148280C (en) 1985-11-18
FI63587B (en) 1983-03-31
AU3938978A (en) 1980-03-06
PH13949A (en) 1980-11-04
EP0001113B1 (en) 1981-11-11
IE781788L (en) 1979-03-06
HK1085A (en) 1985-01-11
EP0001113A1 (en) 1979-03-21
DE2838851A1 (en) 1979-03-22
LU90207A9 (en)
CA1103246A1 (en)
IE47261B1 (en) 1984-02-08
DK148280B (en) 1985-05-28
IL55465A (en) 1982-02-28
GB2003877B (en) 1982-03-17
DK392778A (en) 1979-03-07
IT7827396D0 (en) 1978-09-06
AT364851B (en) 1981-11-25
JPS5448792A (en) 1979-04-17
CA1103246A (en) 1981-06-16
GR73066B (en) 1984-01-30
NO149174C (en) 1984-02-29
ES473074A1 (en) 1979-10-16
GB2003877A (en) 1979-03-21
DE2861316D1 (en) 1982-01-14
IT1099046B (en) 1985-09-18
NO783032L (en) 1979-03-07
LU90207I2 (en) 1998-04-29
NL7809015A (en) 1979-03-08
CS202019B2 (en) 1980-12-31
US4180662A (en) 1979-12-25
NO149174B (en) 1983-11-21
NZ188320A (en) 1981-01-23
BR7805845A (en) 1979-04-24
AU518216B2 (en) 1981-09-17

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