SE7808184A - New prostaglandin Iy2 derivatives and seen to be the same stella - Google Patents

New prostaglandin Iy2 derivatives and seen to be the same stella

Info

Publication number
SE7808184A
SE7808184A SE7808184A SE7808184A SE7808184A SE 7808184 A SE7808184 A SE 7808184A SE 7808184 A SE7808184 A SE 7808184A SE 7808184 A SE7808184 A SE 7808184A SE 7808184 A SE7808184 A SE 7808184A
Authority
SE
Sweden
Prior art keywords
oh
alkyl
hydrogen
group
carbon atoms
Prior art date
Application number
SE7808184A
Other languages
Swedish (sv)
Other versions
SE443978B (en
Inventor
W Skuballa
B Raduchel
N Schwarz
H Vorbruggen
B Muller
G Mannesmann
O Loge
E Schillinger
J Casals-Stenzel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2734791A priority Critical patent/DE2734791C2/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of SE7808184A publication Critical patent/SE7808184A/en
Publication of SE443978B publication Critical patent/SE443978B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins Analogues or derivatives thereof
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/821Antiarrhythmic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/822Anticoagulation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/869Diuretic

Abstract

Prostane derivatives of the formula <IMAGE> I wherein R1 is OR2 or NHR3; R2 is hydrogen, C1-10 alkyl, C4-10 cycloalkyl, C6-10 aryl, or a 5 or 6 membered heterocyclic ring having 1-3 hetero atoms selected from O, N and S; R3 is the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms; W is (a) an OH-substituted methylene group, (b) a <IMAGE> wherein the OH-groups in (a) or (b) can be in the alpha - or beta -position, or (c) such a group wherein the H atom of the OH group is replaced by the residue of a hydrocarbon carboxylic or sulfonic acid of 1-15 carbon atoms or by a conventional etherifying OH-blocking group; R4 is OH or hydroxy whose H atom is replaced as defined for W; and R5, R6, R7, R8, R9, R10 and R11 each independently is hydrogen or alkyl of 1-5 carbon atoms; or R9 and R10 together represent a direct bond; and, when R11 is alkyl, R10 can also be chlorine; and, for a derivative wherein R2 is hydrogen, the salts thereof with physiologically compatible bases, have improved prostaglandin activity.
SE7808184A 1977-07-29 1978-07-27 Prostaglandin-in? 712 derivatives SE443978B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE2734791A DE2734791C2 (en) 1977-07-29 1977-07-29

Publications (2)

Publication Number Publication Date
SE7808184A true SE7808184A (en) 1979-01-30
SE443978B SE443978B (en) 1986-03-17

Family

ID=6015442

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7808184A SE443978B (en) 1977-07-29 1978-07-27 Prostaglandin-in? 712 derivatives

Country Status (26)

Country Link
US (1) US4191694A (en)
JP (1) JPS6259700B2 (en)
AT (1) AT371454B (en)
AU (1) AU523593B2 (en)
BE (1) BE869372A (en)
CA (1) CA1180700A (en)
CH (1) CH636354A5 (en)
CS (1) CS207640B2 (en)
DD (1) DD138904A5 (en)
DE (1) DE2734791C2 (en)
DK (1) DK149954C (en)
ES (1) ES472099A1 (en)
FR (1) FR2398741B1 (en)
GB (1) GB2001650B (en)
GR (1) GR72256B (en)
HU (1) HU179346B (en)
IE (1) IE47304B1 (en)
IL (1) IL55236A (en)
IT (1) IT1097554B (en)
LU (1) LU80043A1 (en)
NL (1) NL7806861A (en)
NZ (1) NZ187849A (en)
SE (1) SE443978B (en)
SU (1) SU921465A3 (en)
YU (1) YU41595B (en)
ZA (1) ZA7804307B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278815A (en) * 1979-04-02 1981-07-14 The Upjohn Company 19-Keto-PG amides
US4264524A (en) * 1979-04-02 1981-04-28 The Upjohn Company 19,20-Didehydro-PG1 amides
US4281191A (en) * 1979-04-02 1981-07-28 The Upjohn Company 19-Hydroxy-19-methyl-PG amides
US4283350A (en) * 1979-04-02 1981-08-11 The Upjohn Company 19,20-Didehydro-PG2 amides
US4276436A (en) * 1979-04-02 1981-06-30 The Upjohn Company 19-Keto-PG sulfonylamides
US4283351A (en) * 1979-04-02 1981-08-11 The Upjohn Company 19,20-Didehydro-13,14-dihydro-PG2 amides
US4264523A (en) * 1979-04-02 1981-04-28 The Upjohn Company 19,20-Didehydro-13,14-dihydro-PG1 amides
US4312997A (en) * 1979-07-05 1982-01-26 The Upjohn Company 19-Hydroxy-6-oxo-PGF1 amides
US4281150A (en) * 1979-07-05 1981-07-28 The Upjohn Company 19-Hydroxy-19-methyl-6a-carba-PGI2 sulfonylamides
US4267371A (en) * 1979-07-05 1981-05-12 The Upjohn Company 19-Hydroxy-6a-carba-PGI2 amides
US4289904A (en) * 1979-07-05 1981-09-15 The Upjohn Company 19-Hydroxy-6a-carba-PGI2 sulfonylamides
US4267352A (en) * 1979-07-05 1981-05-12 The Upjohn Company 19-Hydroxy-19-methyl-6-oxo-PGF1 sulfonylamides
JPS6033429B2 (en) * 1980-04-28 1985-08-02 Ono Pharmaceutical Co
DE3041602A1 (en) * 1980-10-31 1982-06-16 Schering Ag New 5-cyano-prostacyclin derivatives, methods for their manufacture and their use as medicines
DE3107100A1 (en) * 1981-02-20 1982-09-09 Schering Ag Azaprostacycline, methods for their manufacture and their pharmaceutical use
JPH0153672B2 (en) * 1982-01-20 1989-11-15 Toray Industries
US4539433A (en) * 1982-11-24 1985-09-03 Tdk Corporation Electromagnetic shield
JPH0284398U (en) * 1988-12-20 1990-06-29
JPH0397493U (en) * 1990-01-23 1991-10-07
JPH0726876Y2 (en) * 1990-07-02 1995-06-14 日立フェライト株式会社 Anechoic chamber for electromagnetic wave absorber
KR930011548B1 (en) * 1991-08-13 1993-12-10 박원희 Electric wave absorber

Also Published As

Publication number Publication date
ATA551578A (en) 1982-11-15
CH636354A5 (en) 1983-05-31
AT371454B (en) 1983-06-27
YU41595B (en) 1987-10-31
DK149954C (en) 1987-06-15
ES472099A1 (en) 1979-03-16
IE781538L (en) 1979-01-29
CA1180700A1 (en)
FR2398741A1 (en) 1979-02-23
NL7806861A (en) 1979-01-31
DK336878A (en) 1979-01-30
IE47304B1 (en) 1984-02-22
SE443978B (en) 1986-03-17
IT1097554B (en) 1985-08-31
ZA7804307B (en) 1979-07-25
IL55236A (en) 1982-09-30
LU80043A1 (en) 1978-12-12
US4191694A (en) 1980-03-04
IL55236D0 (en) 1978-09-29
CS207640B2 (en) 1981-08-31
YU176278A (en) 1983-01-21
BE869372A (en) 1979-01-29
BE869372A1 (en)
IT7826113D0 (en) 1978-07-26
SU921465A3 (en) 1982-04-15
GB2001650A (en) 1979-02-07
HU179346B (en) 1982-10-28
DK149954B (en) 1986-11-03
NZ187849A (en) 1981-01-23
DE2734791A1 (en) 1979-02-15
DE2734791C2 (en) 1990-09-06
JPS5427556A (en) 1979-03-01
FR2398741B1 (en) 1980-10-31
DD138904A5 (en) 1979-11-28
AU523593B2 (en) 1982-08-05
GB2001650B (en) 1982-03-03
JPS6259700B2 (en) 1987-12-12
GR72256B (en) 1983-10-06
CA1180700A (en) 1985-01-08
AU3843978A (en) 1980-01-31

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