RU97106832A - ANTI-TUMOR EXTRACTS OF COCOA, METHODS FOR PRODUCING THEM, AND USE - Google Patents

ANTI-TUMOR EXTRACTS OF COCOA, METHODS FOR PRODUCING THEM, AND USE

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Publication number
RU97106832A
RU97106832A RU97106832/14A RU97106832A RU97106832A RU 97106832 A RU97106832 A RU 97106832A RU 97106832/14 A RU97106832/14 A RU 97106832/14A RU 97106832 A RU97106832 A RU 97106832A RU 97106832 A RU97106832 A RU 97106832A
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RU
Russia
Prior art keywords
cocoa
procyanidin
extract
beans
powder
Prior art date
Application number
RU97106832/14A
Other languages
Russian (ru)
Other versions
RU2220719C2 (en
Inventor
Дж.Романжик Лео (младший)
Ф.Хаммерстоун Джон (младший)
М.Бук Маргарет
Original Assignee
Марс, Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/317,226 external-priority patent/US5554645A/en
Application filed by Марс, Инкорпорейтед filed Critical Марс, Инкорпорейтед
Publication of RU97106832A publication Critical patent/RU97106832A/en
Application granted granted Critical
Publication of RU2220719C2 publication Critical patent/RU2220719C2/en

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Claims (26)

1. В основном, чистый экстракт какао, отличающийся тем, что содержит полифенол (полифенолы) какао.1. Basically, pure cocoa extract, characterized in that it contains cocoa polyphenol (s). 2. Экстракт по п. 1, полученный способом, предусматривающим измельчение какао-бобов в порошок; обезжиривание указанного порошка; и экстрагирование из этого порошка полифенола (полифенолов) какао, и его очистку. 2. The extract according to claim 1, obtained by a method comprising grinding cocoa beans into powder; degreasing said powder; and extracting and refining cocoa polyphenol (s) from this powder; 3. Экстракт по п. 2, отличающийся тем, что указанный способ измельчения бобов какао в порошок предусматривает лиофилизацию какао-бобов и мякоти; удаление мякоти из лиофилизованной массы; шелушение лиофилизованных какао-бобов; и измельчение очищенных от кожуры бобов. 3. The extract according to claim 2, characterized in that said method of grinding cocoa beans into powder involves lyophilization of cocoa beans and pulp; removal of pulp from the lyophilized mass; peeling of lyophilized cocoa beans; and chopping peeled beans. 4. Экстракт по любому из п. 2 или 3, отличающийся тем, что указанный способ дополнительно предусматривает очистку указанного экстракта с помощью гельпроникающей хроматографии и/или препаративной высокоразрешающей жидкостной хроматографии (ВРЖХ). 4. The extract according to any one of p. 2 or 3, characterized in that the method further comprises purifying said extract using gel permeation chromatography and / or preparative high resolution liquid chromatography (HPLC). 5. Экстракт по п. 4, отличающийся тем, что содержит полифенол (полифенолы), включающий в себя, по крайней мере, один процианидин какао, выбранный из группы, состоящей из (-)-эпикатехина, процианидина В-2, олигомеров процианидина 4-12, процианидина В-5, процианидина А-2, и процианидина С-1. 5. The extract according to claim 4, characterized in that it contains polyphenol (polyphenols), including at least one cocoa procyanidin selected from the group consisting of (-) - epicatechin, procyanidin B-2, procyanidin 4 oligomers -12, procyanidin B-5, procyanidin A-2, and procyanidin C-1. 6. Противоопухолевая композиция, содержащая, в основном, чистый экстракт какао или синтетический полифенол(ы) какао, и подходящий носитель. 6. An antitumor composition comprising substantially pure cocoa extract or synthetic cocoa polyphenol (s) and a suitable carrier. 7. Противоопухолевая композиция по п. 6, отличающаяся тем, что содержит, в основном, чистый экстракт какао, включающий в себя процианидин(ы) какао. 7. The antitumor composition according to claim 6, characterized in that it contains mainly pure cocoa extract, including cocoa procyanidin (s). 8. Противоопухолевая композиция по п. 7, отличающаяся тем, что указанный процианидин(ы) какао получают способом, предусматривающим измельчение какао-бобов в порошок; обезжиривание указанного порошка; и экстрагирование из этого порошка процианидина (процианидинов) какао. 8. The antitumor composition according to claim 7, characterized in that said cocoa procyanidin (s) are obtained by a method comprising grinding cocoa beans into a powder; degreasing said powder; and extracting cocoa procyanidin (procyanidins) from this powder. 9. Противоопухолевая композиция по п. 8, отличающаяся тем, что указанный способ измельчения какао-бобов в порошок предусматривает лиофилизацию какао-бобов и мякоти; удаление мякоти из лиофилизованной массы; шелушение лиофилизованных какао-бобов; и измельчение очищенных от кожуры бобов. 9. The antitumor composition according to claim 8, characterized in that said method of grinding cocoa beans into powder involves lyophilization of cocoa beans and pulp; removal of pulp from the lyophilized mass; peeling of lyophilized cocoa beans; and chopping peeled beans. 10. Противоопухолевые композиции по любому из п. 8 или 9, отличающиеся тем, что указанный способ дополнительно предусматривает очистку указанного экстракта с помощью гельпроникающей хроматографии и/или препаративной высокоразрешающей жидкостной хроматографии (ВРЖХ). 10. Antitumor compositions according to any one of p. 8 or 9, characterized in that the method further comprises purifying said extract using gel permeation chromatography and / or preparative high resolution liquid chromatography (HPLC). 11. Противоопухолевая композиция по п. 10, отличающаяся тем, что включает в себя полифенол(ы), содержащий, по крайней мере, один процианидин какао, выбранный из группы, состоящей из (-)-эпикатехина, процианидина В-2, олигомеров процианидина 4-12, процианидина В-5, процианидина А-2, и процианидина С-1. 11. The antitumor composition according to claim 10, characterized in that it comprises polyphenol (s) containing at least one cocoa procyanidin selected from the group consisting of (-) - epicatechin, procyanidin B-2, procyanidin oligomers 4-12, procyanidin B-5, procyanidin A-2, and procyanidin C-1. 12. Способ лечения пациента, нуждающегося в лечении противоопухолевыми средствами, предусматривающий введение указанному пациенту противоопухолевой композиции, содержащей эффективное количество, в основном, чистого экстракта какао или синтетического полифенола (полифенолов) какао, и подходящего носителя. 12. A method of treating a patient in need of anticancer treatment, comprising administering to said patient an antitumor composition comprising an effective amount of a substantially pure cocoa extract or synthetic cocoa polyphenol (s), and a suitable carrier. 13. Способ по п. 12, отличающийся тем, что указанное противоопухолевое средство включает в себя, в основном, чистый экстракт какао, содержащий процианидин(ы) какао. 13. The method according to p. 12, characterized in that the antitumor agent includes, mainly, a pure cocoa extract containing cocoa procyanidin (s). 14. Способ по п. 13, отличающийся тем, что указанный процианидин(ы) какао получают способом, предусматривающим измельчение какао-бобов в порошок; обезжиривание указанного порошка; и экстрагирование из этого порошка процианидина (процианидинов) какао. 14. The method according to p. 13, characterized in that the said cocoa procyanidin (s) is obtained by a method comprising grinding cocoa beans into a powder; degreasing said powder; and extracting cocoa procyanidin (procyanidins) from this powder. 15. Способ по п. 14, отличающийся тем, что указанный способ измельчения какао-бобов в порошок предусматривает лиофилизацию какао-бобов и мякоти; удаление мякоти из лиофилизованной массы; шелушение лиофилизованных какао-бобов; и измельчение очищенных от кожуры бобов. 15. The method according to p. 14, characterized in that the said method of grinding cocoa beans into powder involves lyophilization of cocoa beans and pulp; removal of pulp from the lyophilized mass; peeling of lyophilized cocoa beans; and chopping peeled beans. 16. Способ по любому из п. 14 или 15, отличающийся тем, что дополнительно предусматривает очистку указанного экстракта путем гельпроникающей хроматографии и/или путем препаративной высокоразрешающей жидкостной хроматографии (ВРЖХ). 16. The method according to any one of p. 14 or 15, characterized in that it further comprises purifying said extract by gel permeation chromatography and / or by preparative high resolution liquid chromatography (HPLC). 17. Способ по п. 16, отличающийся тем, что указанный экстракт включает в себя полифенол(ы), содержащий, по крайней мере, один процианидин какао, выбранный из группы, состоящей из (-)-эпикатехина, процианидина В-2, олигомеров процианидина 4-12, процианидина В-5, процианидина А-2, и процианидина С-1. 17. The method according to p. 16, characterized in that said extract includes polyphenol (s) containing at least one cocoa procyanidin selected from the group consisting of (-) - epicatechin, procyanidin B-2, oligomers procyanidin 4-12, procyanidin B-5, procyanidin A-2, and procyanidin C-1. 18. Набор для лечения пациента, нуждающегося в лечении противоопухолевым средством, включающий в себя, в основном, чистый экстракт какао или синтетический полифенол(ы) какао, и подходящий носитель. 18. A kit for treating a patient in need of treatment with an antitumor agent, comprising essentially pure cocoa extract or synthetic cocoa polyphenol (s), and a suitable carrier. 19. Набор по п. 18, отличающийся тем, что указанное противоопухолевое средство включает в себя, в основном, чистый экстракт какао, содержащий процианидин(ы); и где указанный набор включает в себя инструкции по использованию смеси ингредиентов и/или по введению их пациенту. 19. The kit according to p. 18, characterized in that the antitumor agent includes, mainly, a pure cocoa extract containing procyanidin (s); and wherein said kit includes instructions for using a mixture of ingredients and / or for administering to a patient. 20. Лиофилизованная противоопухолевая композиция, включающая в себя, в основном, чистый экстракт какао или синтетический полифенол(ы) какао. 20. Lyophilized antitumor composition, which includes mainly pure cocoa extract or synthetic cocoa polyphenol (s). 21. Лиофилизованная противоопухолевая композиция по п. 20, отличающаяся тем, что включает в себя, в основном, чистый экстракт какао, содержащий процианидин(ы) какао. 21. The lyophilized antitumor composition according to claim 20, characterized in that it includes, mainly, a pure cocoa extract containing cocoa procyanidin (s). 22. Противоокислительная или защитная композиция, содержащая, в основном, чистый экстракт какао по п. 1, или синтетический полифенол(ы) какао. 22. An antioxidant or protective composition comprising substantially pure cocoa extract according to claim 1, or synthetic cocoa polyphenol (s). 23. Композиция, ингибирующая топоизомеразу, и содержащая, в основном, чистый экстракт какао по п. 1 или синтетический полифенол(ы) какао. 23. A topoisomerase inhibitory composition and containing substantially pure cocoa extract according to claim 1 or synthetic cocoa polyphenol (s). 24. Способ предупреждения или защиты нужного продукта от окисления, предусматривающий взаимодействие указанного продукта с композицией по п. 22. 24. A method of preventing or protecting the desired product from oxidation, comprising the interaction of the specified product with the composition according to p. 22. 25. Способ по п. 24, отличающийся тем, что указанным продуктом является пищевой продукт. 25. The method according to p. 24, characterized in that said product is a food product. 26. Способ ингибирования топоизомеразы, предусматривающий взаимодействие топоизомеразы с композицией по п. 23. 26. A method of inhibiting topoisomerase, comprising contacting topoisomerase with a composition according to claim 23.
RU97106832/15A 1994-10-03 1995-10-03 Antitumoral cacao extract, methods for their preparing and using RU2220719C2 (en)

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US08/317,226 US5554645A (en) 1994-10-03 1994-10-03 Antineoplastic cocoa extracts and methods for making and using the same
US317,226 1994-10-03

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AU (1) AU696050B2 (en)
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