RU2813163C2 - Particles conjugated to peptide - Google Patents

Abstract

FIELD: biotechnology.

SUBSTANCE: invention relates to the induction of immunological tolerance, and can be used in medicine to induce antigen-specific tolerance in a subject in need. The following is proveded: a tolerogenic particle containing one or more encapsulated antigens selected from an autoimmune antigen, an enzyme for enzyme replacement therapy, or an allergen. The particle has a negative zeta potential of -80 mV to -30 mV, a diameter of 200 to 2,000 nanometers and contains polylactic acid (PLA), polyglycolic acid (PGA), lactide-glycolide copolymer (PLG) or liposome.

EFFECT: proposed particles are capable of inducing immunological tolerance to antigens they contain.

13 cl, 43 dwg, 24 ex

Description

US FEDERAL SUPPORT

The present invention was supported by government grant R01 EB013198 from the National Institutes of Health. The state has certain rights to the present invention.

Related applications

The invention claims benefit from U.S. Provisional Patent Application No. 61/865,389, filed Aug. 13, 2013, U.S. Provisional Patent Application No. 61/869,279, filed Aug. 23, 2013, and U.S. Provisional Patent Application No. 61/887,112, filed October 4, 2013 This application is also related to Patent Cooperation Treaty (PCT) Application No. PCT/US2013/047079, filed June 21, 2013, which claims priority to U.S. Provisional Patent Application No. 61/662,687, filed June 21 2012. The contents of each of these documents are incorporated herein by reference in their entirety.

DESCRIPTION OF THE TEXT FILE SUBMITTED IN ELECTRONIC FORM

The contents of the text file submitted electronically are incorporated herein by reference in their entirety: a copy of the sequence list in machine-readable format (file name: COUR-002_01US_Seqlist.txt, date of entry: August 13, 2013, file size 1.17 MB).

PREREQUISITES FOR CREATION OF THE INVENTION

Inflammatory diseases and disorders are conditions in which an abnormal or otherwise dysregulated inflammatory response contributes to the etiology or severity of the disease. Examples include autoimmune diseases such as type I diabetes and celiac disease.

Many of these diseases are characterized by the infiltration of mononuclear cells at the site of tissue damage or other trauma. Examples of mononuclear cells found in these infiltrates include lymphocytes, particularly T lymphocytes, and cells of the mononuclear phagocyte system (MPS cells), such as monocytes, macrophages, dendritic cells, microglial cells, and others.

Many of the cells found in mononuclear cell infiltrates are possibly involved in these pathological inflammatory responses. For example, in diseases such as multiple sclerosis, CD4 ⁺ T cells are known to play a central role in the pathological autoimmune response. At an earlier stage of T cell activation, dendritic cells and other MPS cells may be responsible for the activation of CD4 ⁺ T cells. MPS cells can also promote inflammation through phagocytosis, although in relation to at least some inflammatory diseases it remains unclear whether such cells are able to contribute to inflammation in the absence of CD4 ⁺ T cells.

Peripheral blood monocytes can be classified into one of two groups depending on whether certain molecules are expressed on the cell surface or not. In particular, human "resident monocytes" or "mature monocytes" are thought to have the CD14 ^lo CD16 ⁺ phenotype (mouse counterpart - CX3CR1 ^hi CCR2 ^- Gr1 ^- ). Another group of cells, "inflammatory monocytes" or "immature monocytes", are thought to have the CD14 ⁺ CD16 ^- phenotype (mouse counterpart - CX ₃ CR1 ^lo CCR2 ⁺ Gr1 ⁺ ). (Geissmann F. et al., 2003 Immunity 19: 71-82)

Importantly, although the latter are considered “inflammatory” in the sense that they are observed to migrate into inflamed tissue from peripheral blood cells of bone marrow origin, they have not been shown to cause inflammation directly or through effects on other cells. The various MPS cells that can be formed upon differentiation of these cells have also not been further shown to cause inflammation.

Traditional clinical strategies for long-term immune suppression for disorders associated with adverse immune responses rely on long-term administration of broad-spectrum immunosuppressive drugs, such as signal 1 blockers such as cyclosporine A (CsA), FK506 (tacrolimus), and corticosteroids. Long-term use of high doses of such drugs can lead to toxic side effects. Moreover, even in patients able to tolerate these drugs, the need for lifelong therapy with immunosuppressive drugs is associated with a significant risk of severe side effects, including tumors, serious infections, nephrotoxicity, and metabolic disorders.

Methods have been developed for inducing antigen-specific tolerance, including binding of an antigen or peptide to cells. For example, in one method, peptide-induced cellular tolerance involved collecting, isolating and treating peripheral blood cells with disease-specific autoantigens and the coupling reagent ethylene carbodiimide (ECDI) under sterile conditions, followed by reintroduction to the donor/patient. The process is expensive, must be performed under tightly controlled conditions by experienced health professionals, and is limited in the number of centers capable of performing the procedure. The use of red blood cells as a donor cell type expands the possible sources to include allogeneic donors, greatly increasing the supply of source cells and potentially expanding the scope of this treatment to any blood transfusion-certified facility. Such approaches have significant limitations in terms of the provision of source cells and mandatory histocompatibility to minimize the immune response to donor cells. In addition, local processing of cells to attach self-antigens via EDCI poses a significant quality control challenge. Moreover, such approaches also require at least some knowledge of the pathological antigen to which tolerance must be developed.

Recently, peptide-linked particles have been described that eliminate the need for a stock of parent cells and circumvent the histocompatibility requirement of previous approaches, see WO 2010/085509, incorporated herein by reference in its entirety. However, the use of antigens bound to the outer surface of particles is associated with increased anaphylactic reactions and poses significant challenges in terms of chemical interaction, production and control. Surprisingly, it has been found that these adverse events can be avoided when the antigen is encapsulated within the particle. Even more surprising was that the size and charge of the particles could be changed to improve tolerance to certain antigens.

Antigen-specific tolerance is usually not ideal because the specific epitopes/antigens are essentially unknown in human diseases. Moreover, antigens may vary too much between subjects for an antigen-specific approach to be effective, and therefore it would be necessary to determine which antigens would be detected in a particular patient, or would need to couple a library of possible peptides to the particles before administration. The synthesis and individual binding of such peptides is time consuming and expensive. Therefore, there is a need for therapies that address these problems and thus eliminate the need for a source of histocompatible cells.

Summary of the invention

In some embodiments, the present invention provides compositions (eg, for inducing antigen-specific tolerance) comprising a carrier particle (eg, a PLG particle) coupled to an antigenic peptide. In certain embodiments, the carrier particle is a lactide-glycolide (PLG) copolymer particle. In other embodiments, the carrier particle is a PLURIONICS® stabilized polypropylene sulfide particle.

In some embodiments, the present invention provides compositions comprising an antigen associated with a carrier particle having a negative zeta potential. In some embodiments, the zeta potential of the particle is from about -100 mV to about 0 mV. In some embodiments, the zeta potential of the particle is from about -50 mV to about -40 mV. In some embodiments, the particle is a copolymer having a molar ratio of from about 50:50, 80:20 to about 100:0. In some embodiments, the copolymer ratio may be, but is not limited to, polystyrene:poly(vinyl carboxylate)/80:20. polystyrene : poly(vinylcarboxylate)/90 : 10, poly(vinylcarboxylate) : polystyrene/80 : 20, poly(vinylcarboxylate) : polystyrene/90 : 10, polylactic acid : polyglycolic acid/80 : 20, polylactic acid : polyglycolic acid/90 : 10 or polylactic acid : polyglycolic acid/50 : 50. In other embodiments, the particle is a polystyrene particle, a carboxylated polystyrene particle, a PLURIONICS®-stabilized propylene sulfide particle, or a lactic-glycolic acid copolymer particle. In some embodiments, the particle is a lactic acid-glycolic acid copolymer particle.

In some embodiments, the average particle diameter is from about 0.1 μm to about 10 μm. In some embodiments, the average particle diameter is from 0.2 μm to about 2 μm. In some embodiments, the particle diameter is from about 0.3 μm to about 5 μm. In some embodiments, the particle diameter is from about 0.5 μm to about 3 μm. In some embodiments, the particle diameter is from about 0.5 μm to about 1 μm. In some embodiments, the particle diameter is about 0.5 microns.

In additional embodiments, the antigen comprises at least a portion of an autoimmune antigen, an antigen expressed on tissue for transplantation into a subject, an enzyme, or an allergen. In some embodiments, the antigen comprises at least a portion of myelin basic protein, acetylcholine receptor, endogenous antigen, myelin oligodendrocyte glycoprotein, pancreatic beta cell antigen, insulin, proinsulin, islet-specific protein, glucose-6-phosphatase catalytic subunit-associated protein (IGRP), glutamate decarboxylase (GAD), collagen type 11, human cartilage gp39, fp130-RAPS, proteolipid protein, fibrillarin, small nucleolar protein, thyroid-stimulating factor receptor, histones, gp70 glycoprotein, pyruvate dehydrogenase-dihydrolipoamide acetyltransferase (PCD-E2), hair antigen follicles, aquaporin 4, desmoglein 1, desmoglein 3, nicotinic acetylcholine receptor, A-gliadin and human tropomyosin isoform 5, buckwheat pollen noticeable (BaGP), peach allergen Pru p 3, milk allergen alpha-s1-casein, celery allergen Api g 1 , Brazil nut allergen Bere1, milk allergen B-lactoglobulin, bovine serum albumin, hazelnut allergen Cora 1.04, egg allergen ovalbumin, antihemophilic factor, advat, cogenate, eloctate, recombinant factor VIII and Fc fusion protein, refacto, Novo VIIa, recombinant factor VII , eptacog alfa, helixate, monanin, coagulation factor IX, vilate, ceredase, agglucerase, cerezim, imiglucerase, Elelso, taliglucerase alpha, fabrazyme, agalsidase beta, aldurazime, alpha-L-iduronidase, myozyme, acid glucosidase, elaprase, iduronate-2 -sulfatase, naglazyme arylsulfatase B or N-acetylgalactosamine-4-sulfatase, protein preparations used to replace an enzyme or coagulation factor, for example myozyme, agglucerase, imiglucerase, taliglucerase, agalsidase beta, L-iduronidase, acid glucosidase, iduronate-2-sulfatase , N-acetylgalactosamine-4-sulfatase, antihemophilic factor, factor VII, eptacog alpha, factor IX, miglustat, romiplastim, epothetin alpha, protein C, laronidase, lumizyme or factor VIII.

In additional embodiments, the antigen comprises an autoimmune antigen, an antigen expressed on tissue for transplantation into a subject, an enzyme, or an allergen. In non-limiting embodiments, the antigen comprises, for example, myelin basic protein, acetylcholine receptor, endogenous antigen, myelin oligodendrocyte glycoprotein, pancreatic beta cell antigen, insulin, glutamate decarboxylase (GAD), collagen type 11, human cartilage gp39, fp130 -RAPS, fibrillarin proteolipid protein, small nucleolar protein, thyroid-stimulating factor receptor, histones, gp70 glycoprotein, pyruvate dehydrogenase-dehydrolipoamide acetyltransferase (PCD-E2), hair follicle antigen, aquaporin 4, desmoglein 1, desmoglein 3, nicotinic acetylcholine receptor, A-gliadin and human tropomyosin isoform 5, buckwheat pollen notable (BaGP), peach allergen Pru p 3, milk allergen alpha-s1-casein, celery allergen Api g 1, Brazil nut allergen Bere1, milk allergen B-lactoglobulin, bovine serum albumin, hazelnut allergen Cor a 1.04, insulin, proinsulin, islet-specific protein associated with the catalytic subunit of glucose-6-phosphatase (IGRP), egg allergen ovalbumin, protein preparations used in replacement of an enzyme or coagulation factor, eg myozyme, agglucerase, imiglucerase, taliglucerase, agalsidase beta, L-iduronidase, acid glucosidase, iduronate-2-sulfatase, N-acetylgalactosamine-4-sulfatase, antihemophilic factor, factor VII, eptacog alpha, factor IX, miglustat, romiplastim, epothetin alpha, protein C, laronidase, lumizyme or factor VIII.

In additional embodiments, the particles are associated with an antigen containing one or more epitopes. In a further embodiment, the epitope is associated with an allergy, an autoimmune disease, an enzyme used in enzyme replacement therapy, a lysosomal storage disease, or an inflammatory disease or disorder. In one embodiment, the epitope is associated with type I diabetes, multiple sclerosis, systemic lupus, neuromyelitis optica, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, membranous nephropathy, bullous pemphigoid, pemphigus vulgaris, myasthenia gravis, mucopolysaccharide storage disease, gangliosidosis, alkaline hypophosphatasia , storage disease cholesterol esters, hyperuricemia, growth hormone deficiency, renal anemia, Gaucher disease, Fabry disease, Hurler disease, Hunter disease, Maroteaux-Lamy disease, hemophilia A, hemophilia B, von Willebrand disease, venous thrombosis, purpura fulminans, mucopolysaccharidosis VI, Pompe disease , celiac disease or inflammatory bowel disease, including Crohn's disease or colitis, such as ulcerative colitis. In a further embodiment, the epitopes are in protein therapeutics used in the replacement of enzymes or coagulation factors such as myozyme, agglucerase, imiglucerase, taliglucerase, agalsidase beta, L-iduronidase, acid glucosidase, iduronate-2-sulfatase, N-acetylgalactosamine-4 -sulfatase, antihemophilic factor, factor VII, eptacog alpha, factor IX, miglustat, romiplastim, epothetin alpha, protein C, laronidase, lumizim, factor VIII. In a further embodiment, the epitope is an epitope described in Table 2 or 3. In one embodiment, the particles are coupled to antigens containing only one epitope associated with one disease and/or disorder. In a further embodiment, the antigens contain more than one epitope that are associated with the same disease and/or disorder. In a further embodiment, the antigens contain more than one epitope that are associated with different diseases and/or disorders.

In some embodiments, the antigen is linked to the particle by a conjugate molecule. In some embodiments, the antigen is linked to the particle by a linker. In some embodiments, the conjugate molecule is ethylene carbodiimide (ECDI). In certain embodiments, the antigen is associated with a streptavidin-biotin complex. In some embodiments, linkers include, but are not limited to, various bifunctional protein coupling agents such as N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP), succinimidyl-4-(N-maleimidomethyl)cyclohexane-1- carboxylate, iminothiolane (IT), bifunctional imidoester derivatives (such as dimethyl adipimidate HCL), active esters (such as disuccinimidyl suberate), aldehydes (such as glutaraldehyde), bis-azide compounds (such as bis-(p-azidobenzoyl)hexanediamide ), bis-diazonium derivatives (such as bis-(p-diazoniumbenzoyl)-ethylenediamine), diisocyanates (such as toluene 2,6-diisocyanate) and compounds with two active fluorine groups (such as 1,5-difluoro-2,4 -dinitrobenzene). Specific coupling agents include N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) and N-succinimidyl-4-(2-pyridylthio)pentanoate (SPP), which form a disulfide bond.

In some embodiments, the antigen is associated with the outer surface of the particle having a negative zeta potential. In some embodiments, the antigen is encapsulated in a particle having a negative zeta potential. In some embodiments, the particle is biodegradable. In some embodiments, the particle is surface functionalized. In some embodiments, the particle is carboxylate surface functionalized.

In some embodiments, the present invention provides methods for inducing antigen-specific tolerance in a subject, comprising administering to said subject an effective amount of a composition comprising an antigen-associated particle, wherein said particle has a negative zeta potential, and wherein said particle and antigen induce tolerance to said antigen in the said subject. In some embodiments, administration is for the purpose of treating or preventing a disease or condition. In some embodiments, administration occurs before or after the onset of a disease or condition caused by said antigen. In some embodiments, the disease or condition is selected from the group consisting of an autoimmune disease, an inflammatory disease, an allergy, a transplant rejection, a lysosomal storage disease, an enzyme deficiency, an inflammatory response, and a hyperimmune response. In some embodiments, the disease or condition is selected from the group consisting of multiple sclerosis, type I diabetes, asthma, food allergy, environmental allergy, celiac disease, inflammatory bowel disease including Crohn's disease or ulcerative colitis, and a condition caused by said antigen in said subject to reduce an excessive response to said antigen. In some embodiments, the methods further include repeating said administration of said composition to said subject.

In a further embodiment, administration of the particles results in activation of induced death of effector T cells.

In a further embodiment, administration of the particles results in effector T cell anergy.

In a further embodiment, administration of the particles results in apoptosis of effector T cells.

In a further embodiment, administration of the particles results in the conversion of effector T cells to regulatory T cells.

In a further embodiment, administration of the particles results in the induction and expansion of both antigen-specific and non-specific regulatory T cells. In a further embodiment, administration of the particles results in the release of effector T cells in the lymph nodes and spleen, inhibiting their ability to migrate to the periphery and cause inflammation.

In a further embodiment, administration of the particles results in a decrease in T cell-dependent antibody production.

In certain embodiments, the present invention provides methods for treating celiac disease in a subject, comprising administering to the subject an effective amount of a composition comprising an antigen-associated particle, wherein the particle has a negative zeta potential. In certain embodiments, the antigen is gliadin or an epitope of gliadin. In some embodiments, the antigen is one or more antigens selected from the group consisting of SEQ ID NOs: 1295-1724, SEQ ID NOs: 1726-1766, and SEQ ID NOs: 4986-5140. In some embodiments, the antigen is gliadin and the antigen-bound particle has an average post-synthesis size of about 600 to 1500 nanometers and an average post-synthesis charge of about -30 to about -80 mV. In some embodiments, the particle has an average post-synthesis size of about 600-1200 nanometers and an average post-synthesis charge of about -40 to about -70 mV. In certain embodiments, the particle has an average post-synthesis size of about 600 μm and an average post-synthesis charge of about -50 mV. In further embodiments, the particle is a polystyrene particle, a carboxylated polystyrene particle, a PLURIONICS-stabilized propylene sulfide particle, or a lactic-glycolic acid copolymer particle.

In some embodiments, the present invention provides methods for treating diabetes in a subject, comprising administering to the subject an effective amount of a composition comprising an antigen-associated particle, wherein the particle has a negative zeta potential. In some embodiments, the diabetes is type I diabetes. In some embodiments, the diabetes is type II diabetes.

In some embodiments, the antigen is insulin, proinsulin, islet-specific protein associated with the catalytic subunit of glucose-6-phosphatase (IGRP), or epitopes derived from insulin, proinsulin, or IGRP. In some embodiments, the antigen is one or more antigens selected from the group consisting of ID NO: 1767-1840, SEQ ID NO: 1842-1962, SEQ ID NO: 1964-2027, SEQ ID NO: 2029-2073, SEQ ID NO: 2075-2113, SEQ ID NO: 2115-2197, SEQ ID NO: 2199-2248, SEQ ID NO: 2250-2259, SEQ ID NO: 2261-2420, SEQ ID NO: 2422-2486 and SEQ ID NO: 2489-2505. In some embodiments, the antigen is insulin and the antigen-bound particle has an average post-synthesis size of about 300 to 800 nanometers and an average post-synthesis charge of about -30 to about -70 mV. In some embodiments, the particle has an average post-synthesis size of about 350-600 nanometers and an average post-synthesis charge of about -40 to about -60 mV. In some embodiments, the particle has an average post-synthesis size of about 500 nanometers and an average post-synthesis charge of about -50 mV. In some embodiments, the antigen is proinsulin and the antigen-bound particle has an average post-synthesis size of about 300 to 800 nanometers and an average post-synthesis charge of about -30 to about -70 mV. In certain embodiments, the particle has an average post-synthesis size of about 400-600 nanometers and an average post-synthesis charge of about -40 to about -60 mV. In some embodiments, the particle has an average post-synthesis size of about 570 nanometers and an average post-synthesis charge of about -45 mV. In some embodiments, the antigen is an IGRP and the antigen-bound particle has an average post-synthesis size of about 300 to 800 nanometers and an average post-synthesis charge of about -30 to about -70 mV. In some embodiments, the particle has an average post-synthesis size of about 400-700 nanometers and an average post-synthesis charge of about -40 to about -60 mV. In some embodiments, the particle has an average post-synthesis size of about 600 nanometers and an average post-synthesis charge of about -40 mV. In certain embodiments, the particle is a polystyrene particle, a carboxylated polystyrene particle, a PLURIONICS-stabilized propylene sulfide particle, or a lactic-glycolic acid copolymer particle.

In some embodiments, the present invention provides methods of treating a subject with enzyme replacement therapy, comprising administering to the subject an effective amount of a composition comprising an antigen-bound particle, wherein the particle has a negative zeta potential. In some embodiments, the subject is subjected to enzyme replacement therapy to treat a disease selected from the group consisting of hemophilia, hemophilia A, hemophilia B, von Willebrand disease, mucopolysaccharide storage disease, gangliosidosis, alkaline hypophosphatasia, cholesteryl ester storage disease, hyperuricemia, growth hormone deficiency, renal anemia, Gaucher disease, Fabry disease, Hurler disease, Pompe disease, Hunter disease and Maroteau-Lami disease. In some embodiments, the antigen-associated particle contains one or more enzymes selected from the group consisting of advat, antihemophilic factor, cogenate, eloctate, recombinant factor VIII-Fc fusion protein, refacto, Novo VIIa, recombinant factor VII, eptacog alpha, helixate, monanin, coagulation factor IX, vilate, ceredase, agglucerase, cerezim, imiglucerase, Elelso, taliglucerase alpha, fabrazyme, agalsidase beta, aldurazime, alpha-L-iduronidase, myozyme, acid glucosidase, elaprase, iduronate-2-sulfatase, naglazyme arylsulfatase B and N-acetylgalactosamine-4-sulfatase. In some embodiments, the particle is a polystyrene particle, a carboxylated polystyrene particle, a PLURIONICS-stabilized propylene sulfide particle, or a lactic-glycolic acid copolymer particle. In certain embodiments, the particle is a copolymer having a molar ratio of from about 80:20 to about 100:0. In certain embodiments, the particle is a polystyrene particle, a carboxylated polystyrene particle, a PLURIONICS-stabilized propylene sulfide particle, or a lactic-glycolic acid copolymer particle . In other embodiments, the particle is a lactic-glycolic acid copolymer particle with a polylactic acid:polyglycolic acid copolymer ratio of about 50:50. In some embodiments, the particle is a lactic-glycolic acid copolymer particle with a polylactic acid:polyglycolic acid copolymer ratio of about 50:50. 50:50.

In a further embodiment, administration of the particles of the invention prevents the accumulation of neutrophils and other granulocytes in the subject. In a further embodiment, the particles of the invention are administered to a subject with cancer.

In one embodiment, administration of the particles of the invention enhances the regeneration of damaged tissue. In a further embodiment, the particles enhance epithelial cell regeneration. In another additional embodiment, the particles enhance the remyelination of neurons. In another embodiment, the subject has an autoimmune disease. In yet another embodiment, the subject has inflammatory bowel disease, including ulcerative colitis and/or Crohn's disease. In yet another embodiment, the subject has multiple sclerosis.

In some embodiments, the composition is administered intravenously. In some embodiments, the composition is administered subcutaneously, orally, intramuscularly, lymph node, intraportally, or as an aerosol. In one embodiment, administration of negatively charged particles induces antigen-specific tolerance in a subject. In one embodiment, the antigen-specific tolerance-inducing particles contain one or more epitopes associated with allergy, autoimmune disease, and/or inflammatory disease. In one embodiment, the epitopes are selected from those described in Table 2 or 3. In one embodiment, the negatively charged particles are particles of polystyrene, diamond, PLURONICS® stabilized polypropylene sulfide, or copolymer of lactic acid-glycolic acid. In one embodiment, the particles are carboxylated. In one embodiment, the zeta potential of the particles is less than about -100 mV. In one embodiment, the particle zeta potential is in the range of about -75 mV to 0 mV, such as -50 mV to 0 mV, or -100 mV to -50 mV, or -75 mV to -50 mV, or -50 mV to -40 mV. In one embodiment, the average particle diameter is from about 0.1 μm to about 10 μm, such as from about 0.2 μm to about 2 μm, or from about 0.3 μm to about 5 μm, or from about 0.5 μm to about 3 µm, or from about 0.5 µm to about 1 µm.

In one embodiment, the subject has an autoimmune disease. In one embodiment, the autoimmune disease is multiple sclerosis, scleroderma, type I diabetes, rheumatoid arthritis, thyroiditis, systemic lupus erythematosus, Raynaud's syndrome, Sjögren's syndrome, autoimmune uveitis, autoimmune myocarditis, inflammatory bowel disease, amyotrophic lateral sclerosis (ALS), systemic lupus, neuromyelitis optica, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, membranous nephropathy, bullous pemphigoid, pemphigus vulgaris, myasthenia gravis, celiac disease, ulcerative colitis or Crohn's disease. In one embodiment, the particle contains a full-length polypeptide or a fragment thereof. In one embodiment, the particle contains one or more epitopes of myelin basic protein. In one embodiment, the myelin basic protein epitope is taken from SEQ ID NO: 4975 or SEQ ID NO: 4976. In one embodiment, the particles contain one or more myelin oligodendrocyte glycoprotein epitopes. In one embodiment, the myelin oligodendrocyte glycoprotein epitope is taken from SEQ ID NO: 1 or SEQ ID NO: 4978. In one embodiment, the particle contains one or more insulin epitopes. In one embodiment, one or more insulin epitopes are taken from SEQ ID NO: 4981. In one embodiment, the particle contains one or more glutamate decarboxylase epitopes. In one embodiment, one or more glutamate decarboxylase epitopes are taken from SEQ ID NO: 4982. In one embodiment, the particle contains one or more proteolipid protein epitopes. In one embodiment, the proteolipid protein epitope is taken from SEQ ID NO: 4977. In one embodiment, the particle contains one or more gliadin epitopes. In one embodiment, the gliadin epitopes comprise SEQ ID NO: 4983-4985.

In some embodiments, the present invention further provides a method for producing a negative zeta potential immunomodified particle, comprising the step of contacting the immunomodified particle precursor with a buffer solution under conditions that promote the formation of a negative zeta potential immunomodified particle. In some embodiments, the immunomodified particle precursor is prepared by copolymerization. In some embodiments, the buffer solution has an alkaline pH. In some embodiments, the buffer solution is sodium bicarbonate, potassium bicarbonate, lithium bicarbonate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, or lithium dihydrogen phosphate.

In some embodiments, the present invention provides a composition comprising an antigen encapsulated within the core of a surface-functionalized liposome. In a further embodiment, the liposome comprises phosphatidylcholine:phosphatidylglycerol:cholesterol in a ratio of 30:30:40. In yet another further embodiment, said antigen comprises an autoimmune antigen, an antigen expressed on tissue for transplantation to a subject, or an allergen. In some embodiments, the particle is a lactic acid-glycolic acid copolymer particle with a polylactic acid:polyglycolic acid copolymer ratio of about 50:50. In some embodiments, the particles comprise PEMA. In some embodiments, PEMA is present at a concentration of from about 0.1% to about 2.0%.

Brief description of the drawings

In FIG. Figure 1 shows (A) a microphage lactide-glycolide (PLG) copolymer particle. B and C demonstrate characterization of surface-functionalized lactide-glycolide copolymer particles by dynamic light scattering, including analysis of particle size distribution, average size (nm), ζ-potential (mV), and peptide binding efficiency (%) OVA _323-339 and PLP _139-151 with PLG-PEMA particles. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a counting rate of 2.5 × ¹⁰⁵ counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles varied between 5-15% per batch but essentially had a Z-average diameter of 567 nm, a maximum diameter of 670 nm, and a polydispersity coefficient of 0.209.

In FIG. Figure 2 shows that PLG nanoparticles induce antigen-specific tolerance. The immunodominant epitope of the proteolipid protein PLP _139-151 (PLG-PLP _139-151 ) was used to induce tolerance to prevent relapse of experimental autoimmune encephalitis (R-EAE). Mice received PLP _139-151 -PLGA (N = 5), or OVA _323-339 -PLGA (N = 5), or unconjugated PLGA (N = 5) on day -7 relative to the time of immunization (day 0) . The peak of the disease was usually observed approximately on days 12-14, and the clinical picture of the disease was scored in mice. Particles without the peptide or particles modified with the control peptide OVA _323-339 did not prevent disease induction. However, the clinical score of PLP _139-151 modified PLGA particles was 0 (no disease) in all cases, except that a low clinical score of less than 1 was observed between days 20 and 30.

In FIG. Figure 3 shows that the type of particle administered influenced the development of EAE in the mouse model. A) shows the mean clinical assessment score and B) shows the mean total score in animals with EAE. Mice received OVA _323-339 -PLS (N = 5), OVA _323-339 -PLGA _PHOSPOREX (N = 5), OVA _323-339 -PLGA _PEMA (N = 5), PLP _139-151 -PLA (N = 5 ), PLP _139-151 -PLGA _PHOSPOREX (N = 5) or PLP _139-151 -PLG _PEMA (N = 5) on day -7 relative to the time of immunization (day 0). The peak of the disease was usually observed approximately on days 12-14, and the clinical picture of the disease was scored in mice. Particles of either composition modified with the control peptide OVA _323-339 did not prevent disease induction. However, PLP _139-151 -bound PLG beads were more effective in reducing R-EAE induction than PLP _139-151- bound commercial PLG particles (phosphorex) or polystyrene particles.

In FIG. Figure 4 shows that mice treated with soluble OVA had a decrease in temperature on day 28 compared to animals treated with OVA-PLG particles. No decrease in body temperature was observed within 1 hour after particle administration.

In FIG. Figure 5 shows that administration of PLP-PLG particles during remission does not cause mortality associated with an anaphylactic reaction. EAE was induced in six to eight week old female SJL/J mice by subcutaneous injection of PLP _139-151 in complete Freund's adjuvant (CFA) and the development of clinical signs of the disease was monitored and recorded (B). On day 21 after disease induction, mice received intravenous injections of soluble PLP _139-151 (white squares) _, soluble OVA _323-339 (white circles), or the same peptides bound to PLG nanoparticles (shaded). Animals' temperature was monitored and recorded every 10 minutes for 1 hour after injection (A).

In FIG. Figure 6 shows the administration of the optimal dose of PLP_139-151-PLG seven days before disease induction. Development of clinical signs of disease was measured in comparison with SJL/J mice treated with OVA_323-339-PLG(A). Female SJL/J mice aged six to eight weeks were intravenously injected with PLG nanoparticles bound to either PLP_139-151(squares), or with OVA_323-339(circles). EAE was induced by subcutaneous injection of PLP_139-151in CFA after 7 days (B), 25 days (C) or 50 days (D). Animals from panel B were monitored for clinical signs of disease for 100 days. On day 8 after disease induction, a subset of mice shown in panel B underwent a delayed-type hypersensitivity (DTH) reaction (E). Selected representative animals from panel B primed with PLP_139-151/CFA (OVA_323-339-PLG and PLP_139-151-PLG), the priming epitope PLP was applied to the ear as a stimulus_139-151 and control peptide OVA_323-339. After 24 h, ear swelling was determined as an indicator of DTH, subtracting responses observed before stimulation. Female SJL/J mice aged six to eight weeks were injected intravenously with PLG nanoparticles coupled to PLP_178-191(triangle), OVA_323-339(circle) or PLP_139-151(square) or only unbound particles (empty circle) (F). EAE was induced 7 days later by intravenous administration of PLP_178-191in CFA and monitored for signs of disease at the time points shown.

In FIG. Figures 7A-D show that prophylactic tolerance was most effective when PLG-PLP particles were administered intravenously or intraperitoneally _139-151 . Animals receiving PLP _139-151 -PLG intravenously did not develop disease and had a mean clinical score of 0 at most time points.

In FIG. 8A-F show that administration of OVA _323-339 -PLG particles inhibited Th1 and Th17 responses in treated animals.

In FIG. 9A-C show decreased immune cell infiltration into the spinal cord in animals treated with PLP _139-151 -PLG, which was more similar to normal tissue than tissue from animals treated with OVA _323-339 -PLG. Animals treated with OVA _323-339 -PLG showed positive staining for CD45, CD4 and CD11b; whereas in animals receiving PLP _139-151 -PLG, staining for these factors was minimal.

In FIG. 10A-C show that administration of PLP _139-151 -PLG particles reduces blood-brain barrier (BBB) disruption and macrophage activation in the spinal cord of treated mice. Animals received either complete Freund's adjuvant (CFA), OVA _323-339 -PLG particles, or PLP _139-151 -PLG particles. Clinical feature scores and percentage of occurrence of EAE were determined (B), and the spinal cord was monitored using in vivo imaging (A and C).

In FIG. 11A and B show the spinal cord of treated mice using in vivo imaging. Panels C–F are graphs showing the quantification of the imaging data.

In FIG. 12 shows that administration of PLG particles encapsulated with the PLP _139-151 peptide inhibited the induction of R-EAE in mice. The ability to encapsulate autoantigens allows for the use of complex mixtures of proteins or even organ homogenates, which is not possible with surface binding, and allows for greater antigen coverage and thus more efficient distribution of epitopes.

In FIG. 13 shows that animals treated with PLP _139-151 -PLG particles and anti-CD25 antibody exhibited an at times higher mean clinical score than animals treated with PLP _139-151 -PLG particles and a control IgG antibody.

In FIG. 14 shows therapeutic tolerance induced by PLP _139-151 -PLG particles in active and adoptive EAE. Adoptive EAE was induced in six to eight week old female SJL/J mice by adoptive transfer of 2.5 x 10 ⁶ blast cells activated with PLP _139-151 . Mice received intravenous peptide PLP _139-151 (squares) or OVA _323-339 (circles) bound to 500 nm PLG nanoparticles after 2 days (A), 14 days (C), 18 days (E) or 21 days (F) after disease induction. The clinical disease score was determined in comparison with that after treatment with splenocytes bound to antigen (A). From mice with tolerance induced by PLP _139-151 or OVA _323-339 , the brain and spinal cord were collected on day 42 for histological analysis. Sections taken from mice in panel A were stained for PLP protein and for CD45 (B). Spinal cord sections taken from mice in panel (C) were stained with Luxol Fast Blue (D). Areas of demyelination and cell infiltration are shown by arrows.

In FIG. 15 are graphs showing the mean clinical scores of mice with active EAE and adoptive EAE after treatment with splenocytes (SP) or OVA-conjugated PLG particles._323-339 or PLP_139-151. Mice received intravenous PLP_139-151-SP, PLP_139-151-PLG, or OVA_323-339-SP, or OVA_323-339-PLG, wherein the peptide was associated with nanoparticles with a size of 500 nm, 10 days (A) or 2 days (B) after the induction of the disease, and the average clinical score was determined. In both cases, PLP particles_139-151-PLG induced tolerance in mice.

In FIG. 16 shows that cell infiltration into the central nervous system was also significantly reduced in PLP-PLG-induced tolerance mice. SJL/J mice were intravenously injected with 500 nm PLG nanoparticles bound to PLP_139-151 (squares) or OVA_323-339(circles), 2 days after induction of EAE by adoptive transfer. At the peak of the disease (day 14), the brain and spinal cord were collected and the number of lymphocytes (B), antigen presenting cells (APCs) (C), microglia (D), peripheral dendritic cells (E), and myeloid dendritic cells ( F) and macrophages (G). The strategy to discriminate against these populations is shown in (A). CNS cell preparations were stimulated with phorbol meristate acetate (PMA) and ionomycin 5 h before intracellular staining for IL-17A and IFN-γ (H).

In FIG. 17 shows that administration of the PLP _139-151 peptide encapsulated in a PLG particle induces tolerance when administered to the particle with PBS. However, administration of anti-PD-1 antibody reduces this tolerance.

In FIG. 18 shows that administration of the PLP _139-151 peptide encapsulated in a PLG particle induces tolerance when administered to the particle with PBS. Administration of an anti-CD40 antibody reduces this tolerance, but the reduction in tolerance is reversed by the addition of an anti-IL-12 antibody.

In FIG. 19A-G show that prophylactic administration of OVA-PLG decreased the secretion of IL-4, IL-5, IL-13 and IL-10 and decreased the levels of serum OVA IgE and eosinophils in the lung.

In FIG. 20 shows that OVA peptide encapsulated in PLG particles, when administered prophylactically, inhibits the OVA-specific secondary immune response in vitro in mediastinal lymph nodes. Lymph node proliferation observed after rechallenge with 25 μg OVA was reduced in OVA-PLG-treated animals (A). Moreover, administration of OVA-PLG reduces cytokine release after repeated OVA stimulation. Levels of IL-4, IL-5, IL-13, and IL-10 are reduced in mice treated with OVA-PLG (B).

In FIG. 21A and B show that therapeutic administration of OVA-PLG reduces the secretion of IL-4, IL-5, IL-13 and IL-10 and reduces the levels of serum OVA IgE and eosinophils in the lung.

In FIG. 22 shows that OVA peptide encapsulated in PLG particles, when administered therapeutically, reduces the level of OVA-specific Th2 cytokines in bronchoalveolar lavage (BAL) better than OVA-bound PLG particles. Mice were intraperitoneally injected with OVA/Alum at a dose of 10 μg/mouse on day 0 and day 14. Mice were intravenously administered either OVA bound to PLG particles or OVA encapsulated in PLG particles on days 28 and 42. Between days 56 and 58, mice were injected with aerosolized OVA three times. The graphs show the secretion of cytokines when animals were administered OVA bound to PLG particles (A) or OVA encapsulated in PLG particles (B).

In FIG. 23 shows the blood glucose level of type I diabetic animals after administration of p31-PLG particles. Administration of p31 peptide-coupled PLG nanoparticles resulted in lower blood glucose levels compared to levels observed with MOG _35-55 peptide-coupled particles (A and B). The percentage of cells secreting IFNγ observed in animals was also reduced in mice treated with p31-PLG compared to mice treated with MOG _35-55 -PLG particles (C).

In FIG. 24A-B show that Treg cells are required for p31-PLG-induced tolerance. Type I diabetes was induced by adoptive transfer. Two hours after transfer of activated cells to NOD.SCID mice, mice were induced to tolerate either p31-PLG particles or MOG _35-55 -PLG particles. The decrease in Treg cell numbers impaired the tolerance induced by p31-PLG particle administration.

In FIG. 25 showed that administration of insulin-linked PLG particles significantly increased the proportion of mice that did not develop diabetes for more than 300 days (69.6% versus 22.7%; p = 0.0027). NOD mice were intravenously administered PLG particles bound to either BSA (N = 22) or insulin (N = 23) at 6, 8, and 10 weeks of age. The development of diabetes in mice was assessed.

In FIG. Figure 26 shows the percentage of donor CD45.1 cells observed in the recipient mouse. In female CD45.2 mice, tolerance was induced by administration of OVA-PLG or Dby-PLG on day -7. On day 1, mice received a radiation dose of 200 rad and were then transplanted with 1 x ¹⁰⁶ , 5 x ¹⁰⁶ , or 1 x ¹⁰⁷ bone marrow cells from male CD45.1 mice on day 0. Tolerance was induced in recipient mice using OVA-PLG, Dby-SP, or Dby-PLG on day 1, and blood was collected for chimerism analysis by FACS.

In FIG. Figure 27 shows the percentage of donor CD45.1 cells in recipient mice after tolerance induction with OVA-PLG, Dby-SP or Dby-PLG on day 1. No significant engraftment was observed in one mouse from the positive control group (~10%). No engrafted donor cells were observed in any of the negative control mice. No significant engraftment was observed in one mouse in the Dby-SP group (~10%). Two OVA-PLG mice engrafted donor cells (~10%): one experienced complete rejection by 16 weeks. In one Dby-PLG mouse, rejection began at week 12 and reached 10% by week 16. In the Dby-PLG group, engraftment ranged from 10-56% at 16 weeks. In OVA-PLG mice, 1) spontaneous engraftment, 2) sequence homology between OVA323 and Dby, or 3) tolerogenic properties of the particles were observed. Dby-PLG particles provided greater engraftment than Dby-SP and OVA-PLG.

In FIG. 28 shows that the timing of tolerance induction affects the percentage of CD45.1 cells in the recipient mouse. In the positive control group, less engraftment was observed (~4%) than expected (~10%). One mouse from the negative control group had 5% engraftment. Of all 3 OVA-PLG groups, engraftment was demonstrated by one mouse in the -7th day, +1st day group (12%). Tolerance on day 1 is of greater clinical significance than tolerance on day 7.

In FIG. 29 shows that coumarin-6 labeled PLGA particles, bound or not bound to antigen, were tracked at 3 hours post-administration, but not at 24 hours post-administration. Particles were monitored 3 hours after injection, but not 24 hours after injection. Sections of the spleen (left column), liver (middle column) and lung (right column) from intact mice without injections (top row) and from mice intravenously treated with fluorescent PLGA/PEMA microparticles, taken 3 hours after injection (middle row) and 24 hours after injection (bottom row), counterstained with DAPI.

In FIG. Figure 30 shows that PLGA particles colocalize with F4/80 ⁺ cells in the liver at 6 and 15 hours.

In FIG. 31 shows that marginal zone macrophages preferentially take up TAMRA-labeled particles associated with PLP _139-151 24 hours after intravenous infusion. The largest percentage of PLP _139-151 ⁺ cells are marginal zone macrophages.

In FIG. Figure 32 shows the dependence of the daily average clinical assessment score on the number of days after PLP139-151/CFA priming. R-EAE induced by PLP139-151/CFA is inhibited in SJL/J mice by inducing immunological tolerance using surface-functionalized lactide-glycolide copolymer particles containing soluble PLP139-151 in their core.

In FIG. 33 showed that mice treated with encapsulated OVA-PLG showed the greatest reduction in eosinophil accumulation.

In FIG. 34 shows that mice treated with encapsulated OVA-PLG exhibited the greatest reduction in serum IgE levels compared to untreated or treated control animals.

In FIG. 35 shows the characterization of surface-functionalized particles containing soluble PLP139-151, a lactide-glycolide copolymer, in their cores by dynamic light scattering analysis. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 1.792 x 105 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a Z-average diameter of 584 nm, a maximum diameter of 679 nm, and a polydispersity coefficient of 0.162. These results are typical of 6 batches of particles synthesized according to the protocol described above.

In FIG. 36 shows the characterization of surface-functionalized lactide-glycolide copolymer particles containing soluble PLP139-151 in their cores by ζ-potential measurements. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 6.67 x 104 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a maximum ζ-potential of −48.9 mV and a ζ-deviation of 5.14 mV. These results are typical of 6 batches of particles synthesized according to the protocol described above.

In FIG. 37 shows the characterization of surface-functionalized particles containing soluble ovalbumin, a lactide-glycolide copolymer in their cores, by dynamic light scattering analysis. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 1.822 x 105 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a Z-average diameter of 569.7 nm, a maximum diameter of 700.3 nm, and a polydispersity coefficient of 0.230. These results are typical of 3 batches of particles synthesized according to the protocol described above.

In FIG. 38 shows the characterization of surface-functionalized lactide-glycolide copolymer particles containing soluble ovalbumin in their cores by ζ-potential measurement. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 2.67 x 104 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a maximum ζ-potential of −52.2 mV and a ζ-deviation of 5.38 mV. These results are typical of 3 batches of particles synthesized according to the protocol described above.

In FIG. 39 is a graph showing that surface-functionalized liposomes containing the soluble PLP _139-151 peptide in their cores induce immunological tolerance in a mouse model of multiple sclerosis. Animals received either surface-functionalized liposomes containing the soluble PLP _139-151 peptide in their cores (circles) or surface-functionalized liposomes containing the soluble OVA _323-339 peptide in their cores (squares). The mean clinical score of animals receiving liposomes containing the PLP _139-151 peptide was lower than that of animals receiving liposomes containing the OVA _323-339 peptide.

In FIG. 40 shows that the charge of the administered particle influenced the development of EAE in a mouse model. Panel (A) shows the mean clinical assessment score and panel (B) shows the mean total score in animals with EAE. Mice received TIMPs (tolerogenic immunomodifying particles) with a charge of -60 mV or -25 mV, conjugated to antigen. Mice were injected with OVA _323-339 -TIMP _-60mv , OVA _323-339 -PLGA _-25mv , PLP _139-151 -TIMP _-60mv or PLP _139-151 -PLGA _-25mv and the clinical score of the disease was determined. The more negatively charged TIMP _-60mV particles induced tolerance more effectively than PLGA _-25mV particles.

In FIG. 41 shows that the charge of the immunomodifying particle is important for directing the immunomodifying particle to the antigen presenting cell. Wild-type or MARCO −/+ animals were treated with either PS-IMP or vehicle. The results indicate that particles with reduced negative charge have lower efficiency due to less interaction with the phagocytic receptor MARCO(A). Anti-MARCO antibody alone is not capable of providing efficacy similar to PLGA IMP (B).

In FIG. Figure 42 shows the key particle parameters required for tolerance in a mouse model of EAE. Panel (A) shows that an average particle size of 500 nm is most effective. Mice were injected with 500 nm OVA _323-339 -PSB particles, 100 nm PLP _139-151 -PSB particles, 500 nm PLP _139-151 -PSB particles, 1.75 μm PLP _139-151 -PSB particles, or 4.5 μm PLP particles _139-151 -PSB and determined the clinical score of the disease. Panel (B) shows that 24 hours after intravenous infusion, fluorescently labeled particles with a 50:50 lactide:glycolide ratio were virtually cleared from the spleen, liver, and lung.

In FIG. 43 shows that TIMPs with encapsulated antigens are more effective than peptide-linked particles. In a mouse model of animal allergy, animals were exposed to OVA as the antigen and then administered empty PLG particles, nothing administered, PLGA particles with OVA bound to the outer surface of the particle (A), or PLGA particles with OVA encapsulated inside the particle. (TIMP) (B). Panel (A) shows that OVA-PLG particles with the peptide attached to the surface do not reduce the TH2 response. Panel (B) shows that TIMP _PEMA-60mv particles (OVA encapsulated within the particle) inhibit the TH2 response. Panel (C) shows that TIMP _PEMA-60mv particles (OVA encapsulated within the particle) inhibit the secondary immune response.

DETAILED DESCRIPTION OF THE INVENTION

The present inventors have discovered that antigen-coupled nanoparticles can induce tolerance to an autoimmune disease and reduce the immune response. These particles can induce tolerance whether they are bound to the surface of the particle or encapsulated within it. Therefore, these particles may be suitable for the treatment of any disease or condition that is characterized by an excessive inflammatory immune response, such as autoimmune diseases or allergies.

As used herein, the term “particle” refers to a very small amount of any composition of substances of non-tissue origin, which may be a sphere or spherical element, granule or liposome. The term "particle", the term "immunomodifying particle", the term "carrier particle" and the term "bead" may be used interchangeably depending on the context. In addition, the term "particle" can also cover granules and spheres.

The term "negatively charged particle" as used herein means particles modified to have a net surface charge less than zero.

"Carboxylated particles" or "carboxylated beads" or "carboxylated spheres" include any particle modified to have a carboxyl group on its surface. In some embodiments, the addition of a carboxyl group enhances the uptake of particles by phagocytes/monocytes from the circulatory system, for example, through interaction with phagocytic receptors such as MARCO. Carboxylation of the particles can be accomplished with any compound that introduces carboxyl groups, including, without limitation, poly(ethylene maleic anhydride) (PEMA).

As used herein, “antigenic fragment” refers to a fragment, such as a peptide, that is detected by the host's immune system. Examples of antigenic fragments include, but are not limited to, enzymes, autoantigens and/or bacterial or viral proteins, peptides, drugs or components. Without wishing to be bound by any theory, while carboxylated beads themselves can be detected by the immune system, for purposes of the invention, carboxylated beads to which nothing else is attached are not considered an “antigen moiety.”

As used herein, “free granules” or “free particles” or “free spheres” refer to granules, particles or spheres that have not been carboxylated.

As used herein, “pro-inflammatory mediators” or “pro-inflammatory polypeptides” refer to polypeptides or fragments thereof that cause, maintain or prolong inflammation in a subject. Examples of proinflammatory mediators include, but are not limited to, cytokines and chemokines.

As used herein, the term “inflammatory monocyte” refers to any myeloid cell expressing any combination of CD14/CD26 and CCR2.

As used herein, the term “inhibitory neutrophil” refers to neutrophils and/or suppressor cells of monocytic origin.

As used herein, the term “Th cell” or “helper T cell” refers to CD4 ⁺ cells. CD4 ⁺ T cells help other white blood cells carry out immunological processes, including the maturation of B cells into plasma cells and memory B cells and the activation of cytotoxic T cells and macrophages. T cells are activated when peptide antigens are presented by MHC class II molecules expressed on the surface of antigen presenting cells (APCs).

As used herein, the term “Th1 cell” refers to a subpopulation of Th cells that produces proinflammatory mediators. Th1 cells secrete cytokines that enhance the immune response and play a role in host defense against pathogens, in part by recruiting neutrophils and macrophages to infected tissues. Th1 cells secrete cytokines such as IFN-gamma, IL2, IL-10, and TNF-alpha/beta to coordinate defense against intracellular pathogens such as viruses and some bacteria.

As used herein, the term “Th2 cells” refers to a subpopulation of Th cells that is involved in the activation and maintenance of antibody-mediated immune responses against extracellular parasites, bacteria, allergens and toxins. Th2 cells are involved in these functions by producing various cytokines, such as IL-4, IL-5, IL-6, IL-9, IL-13 and IL-17E (IL-25), responsible for the production of antibodies, activation of eosinophils and inhibition of certain macrophage functions, thereby providing phagocyte-independent protective responses.

As used herein, the term “Th17 cell” refers to a subpopulation of Th cells. Th17 cells secrete cytokines that enhance the immune response and play a role in host defense against pathogens by recruiting neutrophils and macrophages to infected tissues. Th17 cells secrete cytokines such as IL17, IL21, IL22, IL24, IL26, and TNF-alpha to coordinate defense against extracellular pathogens, including fungi and bacteria.

The term “bound” as used herein refers to an antigen bound to the outer surface of a particle or encapsulated within the particle. Thus, the term “particle-bound antigen” includes both surface binding and encapsulation within the particle.

The term IMP as used herein refers to immunomodifying particles that are not associated with an antigen. The term TIMP as used herein refers to tolerogenic immunomodifying particles that are associated with an antigen. In some embodiments, the antigen is attached to the surface of the TIMP. In other embodiments, the antigen is encapsulated within a TIMP.

The particles can be of any shape or conformation. However, in some embodiments, it is preferable to use particles that are less prone to aggregation in vivo. These embodiments provide examples of particles that are spherical in shape.

Another aspect of the invention relates to a composition containing an immunomodified particle having a negative zeta potential and not containing antigenic fragments. In a further embodiment, the invention provides compositions comprising an immunomodified negative zeta potential particle associated with an antigen. In a further embodiment, the antigen is associated with the outer surface of the particle. In a preferred embodiment, the antigen is encapsulated within the particle.

Another aspect of the invention relates to a method for producing an immunomodified particle having a negative zeta potential and not containing antigenic fragments. The method includes ensuring the interaction of a precursor of an immunomodified particle with a buffer solution under conditions conducive to the formation of an immunomodified particle with a negative zeta potential. In some embodiments, the immunomodified particle precursor is produced through copolymerization. The microstructure of the particle may depend on the copolymerization method.

In some embodiments, the antigenic peptide molecule is linked to a carrier particle (eg, an immunomodified particle) using a conjugate molecule and/or a linker group. In some embodiments, the binding of an antigenic peptide and/or an apoptotic signaling molecule to a carrier (eg, a PLG particle) involves one or more covalent and/or noncovalent interactions. In some embodiments, the antigenic peptide is attached to the surface of a carrier particle with a negative zeta potential. In some embodiments, the antigenic peptide is encapsulated within a carrier particle with a negative zeta potential.

In one embodiment, the buffer solution contacting the immunomodified particle may have an alkaline pH. Suitable alkaline pH for an alkaline solution includes 7.1; 7.5; 8.0; 8.5; 9.5; 10.0; 10.5; 11.0; 11.5; 12.0; 12.5; 13.0 and 13.5. The buffer solution may also consist of any suitable base and its conjugate. In some embodiments, the buffer solution may include, without limitation, sodium bicarbonate, potassium bicarbonate, lithium bicarbonate, potassium dihydrogen phosphate, sodium dihydrogen phosphate, or lithium dihydrogen phosphate, and conjugates thereof.

In one embodiment of the invention, the immunomodified particles contain copolymers. These copolymers can have different molar ratios. A suitable copolymer ratio of the immunomodified particles provided in the present invention may be 25:75, 30:70, 35:65, 40:60, 45:55, 50:50, 55:45, 60:40, 65:35, 70 : 30, 75 : 25, 80 : 20, 81 : 19, 82 : 18, 83 : 17, 84 : 16, 85 : 15, 86 : 14, 87 : 13, 88 : 12, 89 : 11, 90 : 10 , 91:9, 92:8, 93:7, 94:6, 95:5, 96:4, 97:3, 98:2, 99:1, or 100:0. In another embodiment, the copolymer may be periodic , random, linear, branched copolymers (including star, brush or comb copolymers). In some embodiments, the copolymer ratio may be, but is not limited to, polystyrene:poly(vinylcarboxylate)/80:20, polystyrene:poly(vinylcarboxylate)/90:10, poly(vinylcarboxylate):polystyrene/80:20, poly(vinylcarboxylate): polystyrene/90:10, polylactic acid:polyglycolic acid/50:50, polylactic acid:polyglycolic acid/80:20 or polylactic acid:polyglycolic acid/90:10.

In one embodiment, the particles of the invention are prepared by adding a composition containing a polymer (eg, PLGA) to a solution of poly(ethylene maleic anhydride) (PEMA). The concentration of PEMA in the solution can range from about 0.1% to about 10%. In one embodiment, the concentration of PEMA in the solution is from about 0.2% to about 5%. In another embodiment, the concentration of PEMA in the solution is from about 0.1% to 4%. In another embodiment, the concentration of PEMA in the solution is from about 0.1% to 2%. In another embodiment, the concentration of PEMA in the solution is from about 0.5% to 1%. In one embodiment, the percentage of PEMA in the solution is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 6%, 6.5%, 7% , 7.5%, 8%, 8.5%, 9%, 9.5% or 10%. In one embodiment, the percentage of PEMA in the solution is about 0.5%. In another embodiment, the percentage of PEMA in the solution is about 1.0%. Other compounds that may be used include, but are not limited to, poly(ethylene-alt-maleic anhydride), poly(isobutylene-co-maleic acid), poly(methyl vinyl ether-alt-maleic acid), poly(methyl vinyl ether- alt-maleic acid monoethyl ester), poly(methyl vinyl ether-alt-maleic anhydride), poly(methyl vinyl ether-alt-maleic anhydride), cross-linked with 1,9-decadiene powder and/or poly(styrene-alt-maleic acid) sodium salt.

In one embodiment, the particle is a liposome. In a further embodiment, the particle is a liposome containing the following lipids in the following molar ratios - 30:30:40 phosphatidylcholine:phosphatidylglycerol:cholesterol. In yet another embodiment, the antigen is encapsulated within a liposome.

It is not necessary that all particles be the same size, although particles generally should be of a size sufficient to be sequestered in the spleen or liver and trigger phagocytosis or uptake, through a receptor or non-receptor mechanism, by an antigen-presenting cell, including an endothelial cell or another cell of the mononuclear phagocyte system (MPS). ). Preferably, the particles are microscopic or nanoscopic in size to enhance solubility, prevent possible complications caused by in vivo aggregation, and promote pinocytosis. Particle size may be a factor influencing uptake from the interstitial space into the area of lymphocyte maturation. A particle with an average diameter of about 0.1 μm to about 10 μm is capable of triggering phagocytosis. Thus, in one embodiment, the particle diameter is within these limits. In another embodiment, the average particle diameter is from about 0.3 μm to about 5 μm. In yet another embodiment, the average particle diameter is from about 0.5 μm to about 3 μm. In another embodiment, the average particle diameter is from about 0.2 μm to about 2 μm. In a further embodiment, the average particle size is about 0.1 μm, or about 0.2 μm, or about 0.3 μm, or about 0.4 μm, or about 0.5 μm, or about 1.0 μm, or about 1.5 microns, or about 2.0 microns, or about 2.5 microns, or about 3.0 microns, or about 3.5 microns, or about 4.0 microns, or about 4.5 microns, or about 5 .0 µm. In a specific embodiment, the particle has an average particle size of 0.5 μm. In some embodiments, the total particle mass is less than about 10,000 kDa, less than about 5000 kDa, or less than about 1000 kDa, 500 kDa, 400 kDa, 300 kDa, 200 kDa, 100 kDa, 50 kDa, 20 kDa, 10 kDa. The particles in the composition do not necessarily have to be the same diameter. As an example, the pharmaceutical composition may contain a plurality of particles, some of which are about 0.5 microns in size and others about 1.0 microns in size. Any combination of particle sizes within these specified ranges will be suitable.

The particles of the present invention may have a certain zeta potential. In certain embodiments, the zeta potential is negative. In one embodiment, the zeta potential is less than about -100 mV. In one embodiment, the zeta potential is less than about -50 mV. In certain embodiments, the zeta potential of the particles is in the range of -100 mV to 0 mV. In a further embodiment, the zeta potential of the particles is in the range of -75 mV to 0 mV. In a further embodiment, the zeta potential of the particles is in the range of -60 mV to 0 mV. In a further embodiment, the zeta potential of the particles is in the range of -50 mV to 0 mV. In a further embodiment, the zeta potential of the particles is in the range of -40 mV to 0 mV. In a further embodiment, the zeta potential of the particles is in the range of -30 mV to 0 mV. In a further embodiment, the zeta potential of the particles is in the range of -20 mV to +0 mV. In a further embodiment, the zeta potential of the particles is in the range of -10 mV to -0 mV. In a further embodiment, the zeta potential of the particles is in the range of -100 mV to -50 mV. In another specific embodiment, the zeta potential of the particles is in the range of -75 mV to 50 mV. In a specific embodiment, the zeta potential of the particles is in the range of -50 mV to -40 mV.

In some embodiments, the charge of the carrier (eg, positive, negative, neutral) is selected to impart application-specific beneficial properties (eg, physiological compatibility, favorable peptide-surface interactions, etc.). In some embodiments, the carrier has a net neutral or negative charge (eg, to reduce nonspecific binding to a cell surface that typically carries a net negative charge). In some embodiments, the carriers may be conjugated, directly or indirectly, to an antigen to which tolerance is desired (also referred to herein as antigen-specific peptide, antigenic peptide, self-antigen, inducing antigen, or tolerance-inducing antigen). In some cases, the carrier has multiple binding sites (e.g., 2, 3, 4, 5, 6, 7, 8, 9, 10... 20... 50... 100 or more) such that there are multiple instances of the antigen-specific peptide or multiple different peptides , exposed on the surface (for example, to increase the likelihood of a tolerogenic response). In some embodiments, the carrier exhibits one type of antigenic peptide. In some embodiments, the carrier displays a plurality of different antigenic peptides on its surface. In some embodiments, the surface of the carrier has functional groups for covalent attachment of selected moieties (eg, antigenic peptides). In some embodiments, functional groups on the surface of the support provide sites for non-covalent interaction with selected moieties (eg, antigenic peptides). In some embodiments, the carrier has a surface onto which conjugated moieties can be absorbed without forming chemical bonds.

Particle size and charge are critical for tolerance induction. Although particles will vary in size and charge depending on the antigen encapsulated therein (see Table 1 for examples of specific particles), in general, particles of the present invention are effective in inducing tolerance when they are between about 100 nanometers and about 1500 nanometers in size and have charge from 0 to about -70 mV, and are most effective at inducing tolerance if they are 400-800 µm in size and charge from about -25 mV to -70 mV. Additionally, as shown in Table 1, due in part to particle concentration and the presence of sucrose and D-mannitol during the lyophilization process, the average particle size and charge may vary slightly during lyophilization, and therefore average sizes are reported for both as-synthesized and and after lyophilization. As used herein, the terms "as-synthesized size" and "as-synthesized charge" refer to the size and charge of the particles before lyophilization. The terms "lyophilization size" and "lyophilization charge" refer to the size and charge of the particles after lyophilization.

TABLE 1. ANALYSIS OF TYPICAL PARTICLES

In some embodiments, the particle is non-metallic. In these embodiments, the particle may be formed from a polymer. In a preferred embodiment, the particle is biodegradable in the subject's body. In this embodiment, the particles can be administered to a subject in multiple doses without the particles accumulating in the subject's body. Examples of suitable particles include polystyrene particles, PLGA particles, PLURIONICS stabilized polypropylene sulfide particles and diamond particles.

Preferably, the surface of the particle is formed from a material that minimizes nonspecific or unwanted biological interactions. Interactions between the particle surface and interstitial tissue can influence lymphatic uptake. The surface of the particles may be coated with a material to prevent or reduce nonspecific interactions. Spatial stabilization by coating particles with hydrophilic layers such as poly(ethylene glycol) (PEG) and its copolymers such as PLURONICS® (including poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) copolymers) can reduce nonspecific interactions with interstitial tissue proteins, as demonstrated by improved lymphatic uptake after subcutaneous injections. All these facts indicate the importance of the physical properties of particles for lymphatic absorption. Biodegradable polymers can be used to form all or some of the polymers and/or particles and/or layers. Biodegradable polymers can undergo degradation, for example, as a result of the interaction of functional groups with water in solution. As used herein, the term "decomposition" means achieving solubility by reducing molecular weight or converting hydrophobic groups to hydrophilic groups. Polymers with ester groups are essentially susceptible to spontaneous hydrolysis, such as polylactides and polyglycolides.

The particles of the present invention may also contain additional components. For example, carriers may have imaging agents incorporated into or conjugated to the carrier. An example of an imaging agent carrier nanosphere that is currently commercially available is Kodak X-sight nanospheres. Inorganic quantum-sized luminescent nanocrystals, known as quantum dots (QDs), have proven to be ideal donors for fluorescence resonance energy transfer (FRET) techniques: their high quantum yield and tunable size-dependent Stokes shifts allow particles of various sizes to emit in the blue to infrared ranges. Moreover, their excitation occurs at the same wavelength in the ultraviolet range. (Bruchez, et al., Science, 1998, 281, 2013; Niemeyer, C. M Angew. Chem. Int. Ed. 2003, 42, 5796; Waggoner, A. Methods Enzymol. 1995, 246, 362; Brus, L. E. J. Chem. Phys. 1993, 79, 5566). Quantum dots, such as hybrid organic/inorganic quantum dots based on a class of polymers known as dendrimers, can be used in biological labeling, imaging, and optical biosensing systems (Lemon, et al., J. Am. Chem. Soc. 2000, 122, 12886). Unlike traditional synthesis of inorganic quantum dots, the synthesis of hybrid quantum dot nanoparticles does not require high temperatures or highly toxic unstable reagents (Etienne, et al., Appl. Phys. Lett. 87, 181913, 2005).

The particles can be formed from a wide range of materials. The particle is preferably formed from a material suitable for biological use. For example, the particles may be formed from glass, silica, polyesters of hydroxycarboxylic acids, polyanhydrides of dicarboxylic acids, or copolymers of hydroxycarboxylic acids and dicarboxylic acids. More generally, carrier particles may be formed from straight chain or branched polyesters, substituted or unsubstituted, saturated or unsaturated, linear or cross-linked alkanyl, haloalkyl, thioalkyl, aminoalkyl, aryl, aralkyl, alkenyl, aralkenyl, heteroaryl or alkoxyhydroxy acids, or straight-chain or branched polyanhydrides, substituted or unsubstituted, saturated or unsaturated, linear or cross-linked alkanyl, haloalkyl, thioalkyl, aminoalkyl, aryl, aralkyl, alkenyl, aralkenyl, heteroaryl or alkoxydicarboxylic acids. In addition, the carrier particles can be quantum dots or be formed from quantum dots, for example polystyrene particles with quantum dot properties (Joumaa et al. (2006) Langmuir 22: 1810-6). Carrier particles can also be used, including combinations of ester and anhydride linkages (eg, copolymers of glycolic and sebacic acids). For example, the carrier particles may contain materials including polymers of polyglycolic acid (PGA), polymers of polylactic acid (PLA), polymers of polysebacic acid (PSA), copolymers of lactic-glycolic acid (PLGA or PLG, the terms are interchangeable), copolymers of lactic-sebacic acid acids (PLSA), copolymers of glycolic and sebacic acids (PGSA), polymers of polypropylene sulfide, poly(caprolactone), chitosan, etc. Other biocompatible biodegradable polymers suitable for use in the present invention include polymers or copolymers of caprolactones, carbonates, amides, amino acids, orthoesters, acetals, cyanoacrylates and degradable urethanes, as well as their copolymers with straight chain or branched, substituted or unsubstituted alkanyl, haloalkyl, thioalkyl, aminoalkyl, alkenyl or aromatic hydroxy or dicarboxylic acids. In addition, biologically important amino acids with reactive side chain groups, such as lysine, arginine, aspartic acid, glutamic acid, serine, threonine, tyrosine and cysteine or their enantiomers, can be included in copolymers with any of the above materials to provide reactive groups for conjugation with antigenic peptides and proteins or conjugating fragments. Biodegradable materials suitable for use in the present invention include diamond, PLA, PGA, polypropylene sulfide and PLGA polymers. Biocompatible but non-biodegradable materials can also be used in the carrier particles of the invention. For example, non-biodegradable polymers of acrylates, ethylene vinyl acetates, cellulose acetates, non-degradable urethanes, styrene, vinyl chlorides, vinyl fluorides, vinyl imidazoles, chlorosulfonated olefins, ethylene oxides, vinyl alcohols, TEFLON® (DuPont, Wilmington, DE) and nylons can be used.

The particles of the present invention can be produced by any method well known in the art. Examples of particle production methods include, but are not limited to, microemulsion polymerization, interfacial polymerization, precipitation polymerization, emulsion evaporation, emulsion diffusion, solvent displacement, and salting out (Astete and Sabliov, J. Biomater. Sci. Polymer Edn., 17: 247-289 (2006)). By modifying the production method of PLGA particles, particle properties (eg, size, size distribution, zeta potential, morphology, hydrophobicity/hydrophilicity, polypeptide fixation, etc.) can be controlled. Particle size is influenced by a number of factors including, but not limited to, the concentration of PLGA, the solvent used in particle production, properties of the organic phase, surfactants used in production, viscosity of the dispersant and dispersed phases, properties of the solvent used, temperature of the water used, ultrasonic treatment, evaporation rate, additives, shear stress, sterilization and properties of any encapsulated antigen or polypeptide.

Particle size depends on polymer concentration; the higher the concentration of polymers, the larger the size of the particles formed. For example, if propylene carbonate is used as the solvent, increasing the PLGA concentration from 1% to 4% (w/v) can increase the average particle size from about 205 nm to about 290 nm. Alternatively, in ethyl acetate and 5% Pluronic F-127, increasing the PLGA concentration from 1% to 5% (w/v) increased the average particle size from 120 nm to 230 nm.

The viscosity of the dispersed and dispersed phases is also an important parameter affecting the diffusion process, a key step in the formation of smaller particles. Particle size increases with increasing viscosity of the dispersed phase, and particle size decreases with increasing viscosity of the dispersed phase. As a general rule, the lower the phase ratio of organic solvent to aqueous, the smaller the particle size.

The speed of the homogenizer and the nature of mixing also affect particle size; Typically, increasing the speed and intensity of mixing will result in a decrease in particle size, but there is a point at which additional increases in speed and intensity of mixing will no longer result in a decrease in particle size. Homogenizing the emulsion with a high-pressure homogenizer has a positive effect on size reduction compared to simply mixing. For example, at a phase ratio of 20% in 5% PVA, the average particle size when stirring is 288 nm, and when homogenizing (high pressure 30 MPa (300 bar)) the average particle size is 231 nm.

Significant particle size reduction can be achieved by varying the temperature of the water added to improve solvent diffusion. The average particle size decreases with increasing water temperature.

The properties of the polypeptide encapsulated in the particle also influence the particle size. In general, encapsulation of hydrophobic polypeptides results in smaller particle sizes compared to encapsulation of more hydrophilic polypeptides. In the double emulsion process, fixation of more hydrophilic polypeptides is improved by the use of high molecular weight PLGA and high molecular weight first surfactant that increases intraphase viscosity. The interaction between solvent, polymer and polypeptide affects the efficiency of incorporation of the polypeptide into the particle.

The molecular weight of PLGA influences the final average particle size. Generally, the higher the molecular weight, the larger the average particle size. For example, when changing the composition and molecular weight of PLGA (e.g., 12-48 kDa for 50:50 PLGA; 12-98 kDa for 75:25 PLGA), the average particle size will vary (about 102-154 nm; about 132-152 nm, respectively ). Even when particles have the same molecular weight, their composition can influence the average particle size; for example, particles with a 50:50 ratio essentially produce smaller particles than particles with a 75:25 ratio. Polymer end groups also affect particle size. For example, the resulting ester-terminated particles produce particles with an average particle size of 740 nm (polydispersity index (PI) = 0.394) compared to the average size of acid-terminated PLGA particles of 240 nm (PI = 0.225).

The solvent used can also affect particle size: solvents that reduce the surface tension of a solution also reduce particle size.

The organic solvent is removed by vacuum evaporation to prevent damage to the polymer and polypeptide and to promote reduction in final particle size. Evaporation of the organic solvent under vacuum is more effective in producing smaller particle sizes. For example, vacuum evaporation produces particles with an average particle size that is approximately 30% smaller than the average particle size obtained by conventional evaporation.

The wavelength amplitude of ultrasonication also affects the particle characteristics. To form stable miniemulsions without further changing the droplet size, the wavelength amplitude should be more than 20% during ultrasonic treatment lasting 600-800 s. However, the main disadvantage of ultrasonic treatment is the loss of monodispersity of the formed emulsion.

Organic phases that can be used in the production of the particles of the invention include, but are not limited to, ethyl acetate, methyl ethyl ketone, propylene carbonate and benzyl alcohol. Dispersant phases that can be used include, but are not limited to, poloxamer 188 surfactant.

Various surfactants can be used in the production of the particles of the invention. The surfactant may be anionic, cationic or nonionic. Surfactants of the poloxamer and poloxamine family are widely used for particle synthesis. Surfactants that may be used include, but are not limited to, PEG, Tween-80, gelatin, dextran, Pluronic L-63, PVA, methylcellulose, lecithin, and DMAB. Additionally, biodegradable and biocompatible surfactants include, but are not limited to, vitamin E TPGS (D-α-tocopheryl polyethylene glycol succinate 1000). In certain embodiments, two surfactants are needed (eg, in double emulsion evaporation). The two surfactants may include a hydrophobic surfactant for the first emulsion and a hydrophobic surfactant for the second emulsion.

Solvents that can be used in the production of the particles of the invention include, but are not limited to, acetone, tetrahydrofuran (THF), chloroform and members of the chlorination product family, methyl chloride. When choosing organic solvents, two criteria must be followed: the polymer must be soluble in the solvent, and the solvent must be completely immiscible with the aqueous phase.

Salts that can be used in the production of the particles of the invention include, but are not limited to, magnesium chloride hexahydrate, magnesium acetate tetrahydrate.

Common salting out agents include, but are not limited to, electrolytes (eg, sodium chloride, magnesium acetate, magnesium chloride) or non-electrolytes (eg, sucrose).

The stability and particle size of the invention can be improved by adding compounds including, but not limited to, fatty acids or short carbon chains. The addition of longer lauric acid carbon chains correlates with improved particle performance. Moreover, the addition of hydrophobic additives can improve particle size, polypeptide incorporation into the particle, and release profile. Particle compositions can be stabilized by lyophilization. The addition of a cryoprotectant such as trehalose can reduce particle aggregation after lyophilization.

Suitable beads that are currently commercially available include polystyrene beads such as FluoSpheres (Molecular Probes, Eugene, OR).

In some embodiments, the present invention provides a system comprising: (a) a delivery frame configured to deliver chemical and/or biological agents to a subject; and (b) antigen-bound lactide-glycolide copolymer particles to induce antigen-specific tolerance. In some embodiments, at least a portion of said delivery scaffold is microporous. In some embodiments, the antigen-bound lactide-glycolide copolymer particles are encapsulated within the framework. In some embodiments, the chemical and/or biological agents are selected from the group consisting of protein, peptide, small molecules, nucleic acids, cells, and particles. In some embodiments, the chemical and/or biological agents comprise cells, and said cells comprise pancreatic islet cells.

Physical properties are also related to the functionality of the nanoparticle after its uptake and retention in areas with immature lymphocytes. These include mechanical properties such as stiffness or high elasticity. In some embodiments, the core is a rubbery core, such as a poly(propylene sulfide) (PPS) core, with an outer layer, such as an outer hydrophilic layer, as in PEG or the PPS-PEG system recently developed and described for systemic (but not targeting or immune) ) delivery. A rubbery core is the opposite of an essentially rigid core, as in a polystyrene or metal nanoparticle system. The term "rubbery" refers to certain elastic materials other than natural or synthetic rubbers, a term known to those skilled in the polymer arts. For example, cross-linked EPS can be used to produce a hydrophobic rubbery core. EPS is a polymer that, under oxidative conditions, decomposes to polysulfoxide and the final product polysulfone, transforming from a hydrophobic rubber to a hydrophilic water-soluble polymer. Other sulfide polymers can be adapted for use, the term "sulfide polymer" referring to a polymer that has sulfur present in the backbone of the repeat unit. Other rubbery polymers that can be used are polyesters with a glass transition temperature under hydrated conditions of less than about 37 °C. A hydrophobic core may advantageously be used in combination with a hydrophilic outer layer since the core and outer layer will not tend to mix, ie the outer layer will tend to extend spatially away from the core. Core means a particle with a layer deposited on it. Layer means material covering at least a portion of the core. The layer may be absorbed or covalently bonded. The particle or core can be solid or hollow. Rubbery hydrophobic cores are preferred over rigid hydrophobic cores such as crystalline or glassy (as in the case of polystyrene) cores because particles with rubbery hydrophobic cores can carry more hydrophobic drugs.

Another physical property is the hydrophilicity of the surface. The solubility of the hydrophilic material (uncrosslinked) in water may be at least 1 gram per liter. Spatial stabilization of particles using hydrophilic polymers can improve their uptake from interstitial tissue by reducing nonspecific interactions; however, the increased invisibility of the particle may also reduce its internalization by phagocytic cells in areas with immature lymphocytes. However, the challenge of balancing these competing features has been resolved, and this application describes the development of nanoparticles for efficient lymphatic delivery to dendritic cells (DCs) and other APCs in lymph nodes. Some embodiments include a hydrophilic component, such as a layer of hydrophilic material. Examples of suitable hydrophilic materials are one or more of polyalkylene oxides, polyethylene oxides, polysaccharides, polyacrylic acids and polyesters. The molecular weight of the polymers in the layer can be adjusted to provide a suitable degree of steric isolation in vivo, for example, from about 1000 to about 100,000 or more; It will be readily apparent to those skilled in the art that all ranges and values within explicitly stated ranges, such as between 10,000 and 50,000, should be considered.

Nanoparticles may contain functional groups for additional interactions. Functional groups for additional interaction include electrophiles or nucleophiles; they are suitable for interaction with other molecules. Examples of nucleophiles are primary amines, thiols and hydroxyls. Examples of electrophiles are succinimidyl esters, aldehydes, isocyanates and maleimides.

In order to conjugate antigenic proteins and peptides to carriers, a variety of tools well known in the art can be used. These methods include all standard chemical methods that do not disrupt or severely limit the biological activity of the antigenic peptides and proteins and that allow a significant number of antigenic peptides and proteins to be conjugated to the carrier in an orientation that allows the antigenic peptide or protein to interact with the T-affinity receptor cells. As such, methods are preferred in which the C-terminal regions of an antigenic peptide or protein or the C-terminal regions of a fusion protein containing an antigenic peptide or protein are conjugated to a carrier. The exact chemical reactions will, of course, depend on the nature of the carrier material, the presence or absence of C-terminal connections to the antigenic peptide or protein, and/or the presence or absence of conjugating moieties.

If necessary for accessibility, functional groups can be placed on the particle. One location may be side or end groups on the central polymer, or polymers that coat the central polymer, or polymers otherwise associated with the particle. For example, examples are included herein that describe nanoparticle stabilizing PEG that can be easily functionalized to target specific cells or to deliver protein and peptide drugs.

Conjugates such as ethylene carbodiimide (ECDI), hexamethylene diisocyanate, propylene glycol diglycidyl ether, which contains 2 epoxy residues, and epichlorohydrin can be used to attach peptides or proteins to the surface of the support. Without wishing to be bound by any theory, ECDI is proposed to have two primary functions for tolerance induction: (a) it chemically binds protein/peptides to the cell surface by catalyzing the formation of a peptide bond between the free amine and free carboxyl groups; and (b) it induces host mimicking of apoptotic cell death such that they are taken up in the spleen by host antigen presenting cells (which may include endothelial cells) and induce tolerance. It is this non-immunogenic presentation to host T cells that leads to the direct induction of anergy in autoreactive cells. In addition, ECDI serves as a strong stimulus for the induction of specific regulatory T cells.

In one set of embodiments, the antigenic peptides and proteins are associated with the carrier through a covalent chemical bond. For example, a reactive group or moiety near the C-terminus of an antigen (e.g., a C-terminal carboxyl group or a hydroxyl, thiol, or amino group from an amino acid side chain) can be conjugated by direct chemical reaction directly to a reactive group or moiety on the surface of the support (e.g. the hydroxyl or carboxyl group of a PLA or PGA polymer, the terminal amine or carboxyl group of a dendrimer, or the hydroxyl, carboxyl or phosphate group of a phospholipid). Alternatively, a conjugation moiety may be used that covalently conjugates both the antigenic peptides and proteins and the carrier, thereby linking them together.

Reactive carboxyl groups on the surface of the support can be attached to free amines (for example, from Lys residues) on the antigenic peptide or protein when they react with, for example, 1-ethyl-3-[3,9-dimethylaminopropyl] carbodiimide hydrochloride (EDC) or N -hydroxysuccinimide ester (NHS). Likewise, the same chemical reaction can be used to conjugate free amines on the surface of a support to free carboxyls (eg, from the C-terminus or from Asp or Glu residues) on an antigenic peptide or protein. Alternatively, free amine groups on the surface of the support can be covalently linked to antigenic peptides and proteins or to fusion proteins containing antigenic peptides or proteins using a sulfo-SIAB chemistry essentially as described by Arano et al. (1991) Chem. 2:71-6.

In another embodiment, the antigen to the carrier can be conjugated by a non-covalent bond between the ligand associated with the antigenic peptide or protein and the antiligand attached to the carrier. For example, a tag with a sequence recognized by a biotin ligase can be attached to the C-terminus of an antigenic peptide or protein, and the tag can be biotinylated by the biotin ligase. Biotin can then act as a ligand to non-covalently conjugate the antigenic peptide or protein to avidin or streptavidin, which is adsorbed or otherwise bound to the surface of the carrier as an anti-ligand. Alternatively, with antigenic peptides and proteins as described above fused to an immunoglobulin domain bearing an Fc region, the Fc domain can act as a ligand and Protein A, covalently or non-covalently bound to the surface of the carrier, can act as an anti-ligand and non-covalently conjugate antigenic peptide or protein with a carrier. Other means are well known in the art that can be used to non-covalently conjugate antigenic peptides and proteins to carriers, including metal ion chelation technologies (e.g., using a polyhistidine tag at the C-terminus of the antigenic peptide or protein, or a fusion protein containing the antigenic peptide or protein, and Ni ⁺ -coated support), and these methods can replace the methods described herein.

Conjugation of a nucleic acid fragment to a carrier molecule can be accomplished in any number of ways, typically including one or more cross-linking agents and functional groups on the nucleic acid fragment and the carrier molecule. Linking groups are added to the carrier molecules using standard synthetic chemistry techniques. Linking groups can be added to nucleic acid fragments using standard synthetic chemistry techniques. The health care professional has the option of selecting the antigens to be used in the combinations of the present invention. The inducing antigen present in the combination affects the specificity of the induced tolerogenic response. It may or may not be the same as a target antigen, which is an antigen present in or administered to a subject being treated that is the target of an unwanted immunological response and for which tolerance is desired.

The inducing antigen of the present invention may be a polypeptide, polynucleotide, carbohydrate, glycolipid, or other molecule isolated from a biological source, or it may be a chemically synthesized small molecule, polymer, or derivative of biological material, provided that it has the following properties: ability to induce tolerance when combined with a mucosal-binding component.

In some embodiments, the present invention provides a carrier (eg, an immunomodifying particle) associated with one or more peptides, polypeptides, and/or proteins. In some embodiments, a carrier (eg, a PLG carrier) such as described herein is effective for inducing antigen-specific tolerance and/or preventing the onset of an immune system-related disease (such as EAE in a mouse model) and/or reducing the severity of a pre-existing disease related to the immune system. In some embodiments, the compositions and methods of the present invention can cause T cells to initiate early events associated with T cell activation, but do not allow the T cells to acquire effector function. For example, administration of the compositions of the present invention may result in T cells acquiring a quasi-activated phenotype, such as upregulation of CD69 and/or CD44, but without exerting effector function, as indicated by a lack of IFN-γ or IL-17 synthesis. In some embodiments, administration of the compositions of the present invention results in T cells acquiring a quasi-activated phenotype without conversion of naïve antigen-specific T cells to a regulatory phenotype, such as cells having CD25 ⁺ /Foxp3 ⁺ phenotypes.

In some embodiments, the surface of the support (eg, particles) contains chemical moieties and/or functional groups that allow antigenic peptides and/or other functional elements to be attached to the support (eg, covalently, non-covalently). In some embodiments, the number, orientation, spatial arrangement, etc. of chemical moieties and/or functional groups on the support (e.g., particle) varies in accordance with the chemistry of the support, the desired application, and the like.

In some embodiments, the carrier contains one or more biological or chemical agents attached, adsorbed, encapsulated, and/or contained throughout the carrier. In some embodiments, the chemical or biological agent is encapsulated within and/or contained throughout the particle material. The present invention is not limited to the nature of chemical or biological agents. Such agents include, but are not limited to, proteins, nucleic acid molecules, small molecule drugs, lipids, carbohydrates, cells, cell components, and the like. In some embodiments, two or more (e.g., 3, 4, 5, etc.) various chemical or biological agents. In some embodiments, the agents provide a specific release rate. In some embodiments, multiple different agents provide different release rates. For example, the first agent may be released over a period of several hours, and the second agent may be released over a longer period of time (eg, days, weeks, months, etc.). In some embodiments, the carrier or portion thereof is configured to slowly release biological or chemical agents. In some embodiments, slow release provides release of biologically active amounts of agent over a period of time of at least 30 days (e.g., 40 days, 50 days, 60 days, 70 days, 80 days, 90 days, 100 days, 180 days, etc.). P.). In some embodiments, the carrier or portion thereof is made porous enough to allow cells to grow into the pores. The pore size can be selected based on the specific cell types of interest and/or the amount of ingrowth required. In some embodiments, the particles contain the antigen of interest without other non-peptide active agents, such as drugs or immunomodulators. Moreover, in some embodiments, the particles of the invention do not contain immunostimulatory or immunosuppressive peptides other than the antigen of interest. Additionally, in some embodiments, the particles do not contain other proteins or peptides (eg, costimulatory molecules, MHC molecules, immunostimulatory peptides, or immunosuppressive peptides), either on the surface or encapsulated within the particles.

Surprisingly, it has been found that encapsulating antigen, biological and/or chemical agents into the particle of the invention induces immunological tolerance and has several advantages. First, encapsulated particles induce a slower cytokine response. Secondly, when using multiple antigens, biological and/or chemical agents, encapsulation eliminates the competition between these different molecules that can occur if the agents are attached to the surface of the particle. Third, encapsulation allows a larger number of antigens, biological and/or chemical agents to be contained within a particle. Fourth, encapsulation allows for easier use of complex protein antigens or organ homogenates (eg, pancreatic homogenate for type I diabetes or peanut extract for peanut allergy). Finally, encapsulating antigens, biological and/or chemical agents within the particle rather than conjugating to the particle surface maintains a net negative charge on the particle surface. Encapsulation of antigen, biological and/or chemical agents into the particles of the invention can be accomplished by any method known in the art. In one embodiment, the polypeptide antigens are encapsulated into particles using a double emulsion process. In a further embodiment, the polypeptide antigens are water soluble.

In another embodiment, the polypeptide antigens are encapsulated into particles using a single emulsion process. In a further embodiment, the polypeptide antigens are more hydrophobic. Sometimes the double emulsion process results in the formation of large particles, which can lead to leakage of the active hydrophilic component and reduce the entrapment efficiency. Coalescence and Ostwald ripening are two mechanisms that can destabilize the double emulsion droplet, and diffusion of the hydrophilic active component through the organic phase is the main mechanism responsible for the low level of active component entrapment. In some embodiments, reducing the size of the nanoparticles may be beneficial. One strategy to achieve this goal is to use a second strong shear rate. The leakage effect can be reduced by using a high polymer concentration and a high molecular weight of the polymer, in combination with increasing the viscosity of the internal aqueous phase and increasing the molecular weight of the surfactant.

In certain embodiments, the present invention provides carriers having cells or other biological or chemical agents on their surface (or within). If cells are used, the media are not limited to a specific cell type. In some embodiments, the carriers contain pancreatic islet cells. In some embodiments, the microporous carriers further comprise extracellular matrix (ECM) proteins and/or exendin-4. Media has no restrictions on type. In some embodiments, the support has regions of varying porosity (eg, varying pore size, pore depth, and/or pore density). In some embodiments, they contain on (or within) pharmaceutical agents, DNA, RNA, extracellular matrix proteins, exendin-4, etc. In certain embodiments, the present invention provides methods for transplanting pancreatic islet cells with such carriers. In some embodiments, the inducing antigen is a single isolated or recombinantly produced molecule. To treat conditions in which the target antigen is distributed to different sites in the host, it is essential that the inducing antigen be identical or immunologically related to the target antigen. Examples of such antigens include most polynucleotide antigens and some carbohydrate antigens (eg, blood group antigens).

Any suitable antigens may be used within the scope of the present invention. In some embodiments, the inducing antigen influences the specificity of the tolerogenic response induced. The inducing antigen may or may not be the same as the target antigen, which is an antigen present in or administered to the patient being treated, which is the target for an adverse immunological reaction and for which tolerance is desired.

If an antigen is preferentially expressed on a particular organ, cell, or cell type, the healthcare provider has the option of using an inducing antigen that is identical to or immunologically related to the target antigen. However, there is also the additional possibility of using an antigen foreign to the target. It is an antigen that may not be immunologically related to the target antigen, but is preferentially expressed in the tissue in which the target antigen is expressed. The working theory regarding the effectiveness of suppression by an adventitious agent is that suppression is an active cell-mediated process that reduces the activity of the effector portion of the immune response in target cells. Suppressor cells are specifically stimulated by the inducing antigen on the mucosal surface and move to the tissue area where the foreign antigen is preferentially expressed. Through an interactive or cytokine-mediated mechanism, localized suppressor cells further reduce the activity of effector cells (or inducers of effector cells) in the immediate environment, regardless of what they are responding to. If the effector cells are specific for a target other than the inducing antigen, the result will be a bystander effect. For additional information on reaction to foreign agents and a list of tolerogenic peptides that have this effect, the reader is referred to international patent publication WO 93/16724. An implied implication of the extraneous agent theory is that, in order to practice the present invention, one of ordinary skill in the art does not need to identify or isolate the specific target antigen to which it is desired to develop tolerance. The healthcare provider only needs to obtain at least one molecule, preferably expressed in the target area, for use as the inducing antigen.

In some embodiments, the inducing antigen is of a form that is not identical to the antigen expressed in the subject being treated, but is a fragment or derivative of that antigen. The inducing agents of the present invention contain peptides based on a molecule of appropriate specificity, but adapted through fragmentation, residue substitution, labeling, conjugation and/or fusion with peptides having other functional properties. Adaptation can be carried out for any desired purpose, including, without limitation, the elimination of any undesirable property, such as toxicity or immunogenicity, or to enhance any desired property, such as mucosal binding, mucosal penetration, or stimulation of the tolerogenic branch of the immune response. The terms "insulin peptide", "collagen peptide", "myelin basic protein peptide" as used herein refer not only to the intact subunit, but also to allotypic and synthetic variants, fragments, fusion peptides, conjugates and other derivatives containing a region homologous to ( preferably 70% identical, more preferably 80% identical, and even more preferably 90% identical at the amino acid level) to at least 10, and preferably 20 consecutive amino acids of the corresponding molecule of which it is an analogue, wherein the homologous region of the derivative compound has common ability with the parent molecule to induce tolerance to the target antigen.

It is known that tolerogenic regions of the inducing antigen are often distinguished from immunodominant epitopes to stimulate antibody formation. Tolerogenic regions are essentially regions that can be presented in specific cellular interactions involving T cells. Tolerogenic regions may be presented and may be capable of inducing tolerance when presented with intact antigen. Some antigens contain latent tolerogenic regions in the sense that processing and presentation of the original antigen under normal conditions does not lead to tolerance. A description of the latent antigens and their identification can be found in international patent publication WO 94/27634.

In some embodiments of the present invention, two, three, or more inducing antigens are used. These embodiments may be desirable to implement in the presence of multiple target antigens or to generate multiple off-target agents. For example, both insulin and glucagon can be mixed with a mucosal binding component to treat diabetes. It may also be desirable to create a cocktail of antigens to cover several possible alternative targets. For example, a cocktail of histocompatibility antigen fragments can be used to induce tolerance in a subject who is scheduled to receive an allograft transplant of unknown phenotype in the future. Allovariant regions of human leukocyte antigens are known in the art: for example, Immunogenetics 29:231, 1989. In another example, a mixture of allergens can act as an inducing antigen for the treatment of atopy.

Inducing antigens can be obtained using a number of techniques known in the art, depending on the nature of the molecule. Polynucleotide, polypeptide or carbohydrate antigens can be isolated from those cells of the species to be treated that contain large quantities of these antigens. Short peptides can be conveniently obtained by synthesis from amino acids. Longer peptides of known sequence can be obtained by synthesizing the coding sequence or PCR amplification of the coding sequence from a natural source or vector and then expressing the coding sequence in a suitable bacterial or eukaryotic host cell.

In some embodiments of the present invention, the combination contains a complex mixture of antigens derived from a cell or tissue, one or more of which act as an inducing antigen. Antigens can be in the form of whole cells, intact or treated with a fixative such as formaldehyde, glutaraldehyde or alcohol. Antigens may be in the form of a cell lysate created by detergent solubilization or mechanical disruption of cells or tissue followed by purification. Antigens can also be obtained by subcellular fractionation, in particular by enrichment of the plasma membrane using techniques such as differential centrifugation, optionally followed by detergent solubilization and dialysis. Other separation techniques such as affinity and ion exchange chromatography of solubilized membrane proteins are also suitable.

In one embodiment, the antigenic peptide or protein is a self-antigen, alloantigen, or graft antigen. In yet another specific embodiment, the autoantigen is selected from the group consisting of myelin basic protein, collagen or fragments thereof, DNA, nuclear and nucleolar proteins, mitochondrial proteins and pancreatic β-cell proteins.

The invention provides for the induction of tolerance to an autoantigen for the treatment of autoimmune diseases by introducing the antigen for which it is desired to develop tolerance. For example, autoantibodies to myelin basic protein (MBP) are observed in patients with multiple sclerosis, and accordingly, antigenic peptides or MBP proteins can be used within the scope of the invention and delivered using the compositions of the present invention for the treatment and prevention of multiple sclerosis.

As another non-limiting example, a subject who is a candidate for a non-identical twin transplant may develop rejection of the transplanted cells, tissues, or organs because the transplanted antigens are foreign to the recipient. Preliminary tolerance of the recipient subject to the intended graft eliminates or reduces subsequent rejection. By practicing the present invention, anti-rejection therapy can be reduced or eliminated. In another example, many autoimmune diseases are characterized by a cellular immune response to an endogenous or self-antigen. Tolerance of the immune system to an endogenous antigen is desirable for disease control.

In a further example, a subject's sensitization to an industrial pollutant or chemical compound, which may occur in the workplace, may create a risk of an immune reaction. Preconditioning of a subject's immune system to a chemical, particularly in the form in which the chemical has reacted with the subject's endogenous proteins, may be desirable to prevent subsequent development of an immune response in the workplace.

Allergens are other antigens for which the development of a tolerant immune response is also desirable. In one embodiment, the antigen is gliadin. In a further embodiment, the antigen is A-gliadin.

It should be noted that even in diseases in which the pathogenic autoantigen is unknown, suppression can be induced by an extraneous agent using antigens of a close anatomical location. For example, in rheumatoid arthritis, autoantibodies to collagen are observed, and accordingly, the gene encoding collagen can be used as an antigen expressing gene module in the treatment of rheumatoid arthritis (see, for example, Choy (2000) Curr Opin Investig Drugs 1: 58-62 ). In addition, the development of tolerance to beta cell autoantigens can be used to prevent the development of type I diabetes (see, for example, Bach and Chatenoud (2001) Ann Rev Immunol 19: 131-161).

As another example, autoantibodies to myelin oligodendrocyte glycoprotein (MOG) are observed in autoimmune encephalomyelitis and many other CNS diseases, as well as multiple sclerosis (see, for example, Iglesias et al. (2001) Glia 36: 22-34) . Accordingly, the use of constructs expressing the MOG antigen in the present invention allows for the treatment of multiple sclerosis, as well as related autoimmune diseases of the central nervous system.

Other examples of potential antigens for use in the treatment of autoimmune diseases include pancreatic beta cell antigens, insulin and GAD for the treatment of insulin-dependent diabetes mellitus; collagen type 11, human cartilage glycoprotein gp 39 (HCgp39) and gpl30-RAPS for the treatment of rheumatoid arthritis; myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG, see above) for the treatment of multiple sclerosis; fibrillarin and small nucleolar protein (snoRNP) for the treatment of scleroderma; thyroid-stimulating factor receptor (TSH-R) for the treatment of Graves' disease; nuclear antigens, histones, gp70 glycoprotein and ribosomal proteins for the treatment of systemic lupus erythematosus; pyruvate dehydrogenase dehydrolipoamide acetyltransferase (PCD-E2) for the treatment of primary biliary cirrhosis; hair follicle antigens for the treatment of alopecia areata; human tropomyosin and isoform 5 (hTM5) for the treatment of ulcerative colitis.

In one embodiment, the particles of the invention are associated with antigens containing one or more epitopes associated with allergies, autoimmune diseases and/or inflammatory diseases or disorders. Antigens may contain one or more instances of an epitope. In one embodiment, the antigens contain a single epitope associated with a single disease or disorder. In a further embodiment, the antigens contain more than one epitope that are associated with the same disease or disorder. In another additional embodiment, the antigens contain more than one epitope that are associated with different diseases or disorders. In a further embodiment, the antigens contain one or more epitopes associated with one or more allergies. In a further embodiment, the antigens contain one or more epitopes associated with multiple sclerosis, type I diabetes, celiac disease and/or inflammatory bowel disease, including Crohn's disease or ulcerative colitis. In one embodiment, the epitopes are from myelin basic protein (e.g., SEQ ID NOs: 4975 and 4976), proteolipid protein (e.g., SEQ ID NO: 4977), myelin oligodendrocyte glycoprotein (e.g., SEQ ID NOs: 1 and 4978), aquaporin (e.g., SEQ ID NO: 4979), myelin-associated glycoprotein (e.g., SEQ ID NO: 4980), insulin (e.g., SEQ ID NO: 4981), glutamate decarboxylase (e.g., SEQ ID NO: 4982), gliadin ( for example, SEQ ID NO: 4983-4985 or 5136-5140), type IV collagen α3 chain (for example, SEQ ID NO: 5017) or fragments, homologues or isoforms thereof. In a further embodiment, the epitopes are from gluten, including gliadin and/or glutenin. In one embodiment, the epitopes are from insulin homologs, such as those described in US Pat. No. 8,476,228, the contents of which are incorporated herein for all purposes. In one embodiment, the gliadin epitopes are SEQ ID NO: 13, 14, 16, 320, or 321 in US Patent Application No. 20110293644, the contents of which are incorporated herein in their entirety for all purposes.

Tables 2 and 3 describe additional non-limiting examples of epitopes associated with various autoimmune diseases and/or inflammatory diseases or disorders contemplated by the present invention.

Table 2. Typical linear epitopes

Not all epitopes are linear; epitopes can also be discontinuous, conformational epitopes. A number of discontinuous epitopes are known to be associated with autoimmune diseases or inflammatory diseases and/or disorders. Non-limiting examples of discontinuous epitopes are shown in Table 3.

Table 3. Typical discontinuous epitopes

Combinations of antigens and/or epitopes can be tested for their ability to confer tolerance through experiments with isolated cells or animal models.

In some embodiments, the tolerance-inducing compositions of the present invention contain an apoptotic signaling molecule (eg, in addition to an antigenic peptide or other antigenic molecule). In some embodiments, the apoptotic signaling molecule is bound and/or associated with the surface of the carrier. In some embodiments, apoptotic signaling molecules allow antigen presenting cells of the host, such as cells of the reticuloendothelial system, to perceive the host as an apoptotic body; this allows the presentation of bound peptide epitopes so that tolerance is induced. Without being bound by any theory, it is believed that this prevents increased activation of molecules involved in stimulating immune cells, such as MHC class I/II molecules and costimulatory molecules. Such apoptotic signaling molecules can also act as markers of phagocytosis. For example, apoptotic signaling molecules suitable for the present invention are described in US Patent Application No. 20050113297, which is incorporated herein by reference in its entirety. Molecules suitable for the present invention include molecules targeting phagocytes, including macrophages, dendritic cells, monocytes, granulocytes and neutrophils.

In some embodiments, molecules suitable for use as apoptotic signaling molecules provide the effect of producing tolerance to the associated peptides. In addition, a carrier associated with an apoptotic signaling molecule can bind to Clq during recognition of apoptotic cells (Paidassi et al., (2008) J. Immunol. 180: 2329-2338; incorporated herein by reference in its entirety). For example, molecules that can be used as apoptotic signaling molecules include phosphatidylserine, annexin-1, annexin-5, milk fat globular EGF factor 8 (MFG-E8), or the thrombospondin family (eg, thrombospondin-1 (TSP- 1)). Various molecules suitable for use as apoptotic signaling molecules in the present invention are described, for example, in US patent application 2012/0076831, which is incorporated herein by reference in its entirety).

In some embodiments, the apoptotic signaling molecule may be conjugated to an antigen-specific peptide. In some embodiments, the apoptotic signaling molecule is conjugated to an antigen-specific peptide by creating a fusion protein. For example, the fusion protein may comprise at least one antigen-specific peptide (or fragment or variant thereof) linked to at least one apoptotic signaling molecule (or fragment or variant thereof). In relation to the creation of fusion proteins, the terms "fusion protein", "fusion peptide", "fusion polypeptide" and "chimeric peptide" are used interchangeably. Suitable antigen-specific peptide fragments include any full-length peptide fragment that retains the function of generating the desired antigen-specific tolerance of the present invention. The fusion protein can be created by various methods known in the art (eg, genetic chimerization, chemical conjugation, etc.). The two proteins can be fused directly or using an amino acid linker. Polypeptides forming a fusion protein are typically joined C-terminus to N-terminus, but they can also be joined C-terminus to C-terminus, N-terminus to N-terminus, or N-terminus to C-terminus. The polypeptides in the fusion protein can be in any order. A peptide linker sequence may be used to separate the first and second polypeptide components by a distance sufficient to allow each polypeptide to fold into its secondary and tertiary structures. Amino acid sequences that can be usefully used as linkers include those described in Maratea et. al., Gene 40: 39-46 (1985); Murphy et al., Proc. Natl. Acad. Sci. USA 83: 8258-8262 (1986); US Patent No. 4,935,233 and US Patent 4,751,180, which are incorporated herein by reference in their entirety. The linker sequence may generally be from 1 to about 50 amino acids in length. In some embodiments, linker sequences are not required and/or used, for example, when the first and second polypeptides contain regions with N-terminal non-basic amino acids that can be used to separate functional domains and avoid spatial influences.

An indicator of tolerogenic activity is the ability of an intact antigen or fragment to stimulate the production of the corresponding cytokine in the target area. The immunoregulatory cytokines released by suppressor T cells in the target zone are thought to be TGF-β (Miller et al., Proc. Natl. Acad. Sci. USA 89:421, 1992). Other factors that can be produced under conditions of tolerance are the cytokines IL4 and IL-10, as well as the mediator PGE. Conversely, lymphocytes in tissues that are undergoing active immune destruction secrete cytokines such as IL-I, IL-2, IL-6 and γ-IFN. Therefore, the effectiveness of a potential inducing antigen can be assessed by measuring its ability to stimulate the appropriate type of cytokine.

In light of the above, a rapid screening test to determine tolerogenic epitopes of the inducing antigen, effective mucosal binding components, effective combinations, or effective mucosal routes and regimens can be performed using syngeneic animals as donors for in vitro cell-based assays. Animals are administered a test composition through the surface of the mucous membrane and after some time are stimulated by parenteral administration of the target antigen in complete Freund's adjuvant. Spleen cells are isolated and cultured in vitro in the presence of the target antigen at a concentration of about 50 μg/ml. The target antigen can be replaced with potential proteins or subfragments to map the location of tolerogenic epitopes. The secretion of cytokines in the medium can be quantified using a standard immunoassay.

The ability of cells to suppress the activity of other cells can be determined by using cells isolated from an animal immunized with the target antigen, or by creating a cell line that is sensitive to the target antigen (Ben-Nun et al., Eur. J. Immunol. 11: 195, 1981; entire incorporated herein by reference). In one embodiment of the present experiment, a population of suppressor cells is subjected to mild irradiation (about 1000-1250 rad) to prevent proliferation, the suppressors are co-cultured with responder cells, and then tritium-labeled thymidine (MTT) is administered to quantify the proliferative activity of the responder cells. In another embodiment, the suppressor cell population and the responder cell population are cultured in the upper and lower levels of a Transwell dual-chamber culture system (Costar, Cambridge, Mass.), which allows cell populations within 1 mm of each other to be co-incubated and separated by a polycarbonate membrane (WO 93/16724). With this approach, it is not necessary to irradiate the suppressor cell population, since the proliferative activity of responder cells can be measured separately.

In embodiments of the invention in which the target antigen is already present in the subject, there is no need to isolate the antigen or pre-combine it with a mucosal binding component. For example, an antigen may be expressed in a particular manner in a subject as a consequence of a pathological condition (eg, inflammatory bowel disease or celiac disease) or as a consequence of consumption of a food allergen. Testing is performed by administering the mucosal binding component in one or more doses or formulations and determining the ability to induce tolerance to the antigen in situ.

It is also possible to develop effective compositions and routes of administration for treating a specific disease using appropriate animal models of the disease. The ability of treatment to reduce or delay disease symptoms is monitored by the level of circulating biochemical and immunological indicators of the disease, the results of immunohistological examination of damaged tissue and the main clinical signs corresponding to the model used. Non-limiting examples of animal models that can be used for testing are presented in the next section.

The present invention contemplates the modulation of tolerance by modulation of the TH1 response, the TH2 response, the TH17 response, or a combination of these responses. Modulation of the TH1 response involves changes in the expression of, for example, interferon gamma. Modulation of the TH2 response involves changing the expression of, for example, any combination of IL-4, IL-5, IL-10 and IL-13. Typically, an increase (decrease) in the TH2 response will involve an increase (decrease) in the expression of at least one of IL-4, IL-5, IL-10, or IL-13; most often an increase (attenuation) of the TH2 response will involve an increase in the expression of at least two of IL-4, IL-5, IL-10 or EL-13, most often an increase (attenuation) of the TH2 response will contain an increase in the expression of at least three of the DL -4, IL-5, IL-10 or IL-13, ideally the increase (decrease) in the TH2 response will involve an increase (decrease) in the expression of each of IL-4, IL-5, IL-10 and IL-13. Modulation of TH17 involves changes in the expression of, for example, TGF-beta, IL-6, IL-21 and IL23 and affects the levels of IL-17, IL-21 and IL-22.

Other suitable methods for assessing the effectiveness of the compositions and methods of the present invention are known in the art, as described, for example, in US patent application 2012/0076831 (incorporated herein by reference in its entirety).

Some embodiments of the present invention relate to priming immune tolerance in a subject who has not previously undergone tolerance induction by therapeutic intervention. These embodiments essentially include multiple administrations of a combination of an antigen and a mucosal binding component. To ensure long-term results, priming typically involves at least three administrations, often at least four administrations, and sometimes at least six administrations, although tolerance may occur in a subject early in the course of treatment. Most often, each dose is given as a bolus, but long-acting formulations capable of mucosal release are also suitable for use. If multiple administrations are performed, the time between administrations is generally from 1 day to 3 weeks, and typically from about 3 days to 2 weeks. Essentially, the same antigen and mucosal-binding component are used in the same concentration and administration is carried out on the same mucosal surface, but options for correcting any of these parameters during the course of treatment are also possible.

Other embodiments of the present invention relate to maintaining or prolonging previously developed immune tolerance. These embodiments essentially relate to a single administration or short course of treatment at a time when established tolerance is or may be reduced. Maintenance is essentially performed over a period of 1 month to 1 year and typically 2 to 6 months after priming or previous maintenance. The present invention also includes embodiments that use regular maintenance of tolerance with a dosing schedule of twice a week, once a week, every two weeks, or any other regular schedule.

The particles of the present invention can be administered at any dose effective to suppress the inflammatory immune response in a subject in need of treatment or to treat a bacterial or viral infection in a subject in need of treatment. In certain embodiments, the subject is provided with administration of from about 10 ² to about 10 ²⁰ particles. In a further embodiment, about 10 ³ to about 10 ¹⁵ particles are introduced. In another further embodiment, about 10 ⁶ to about 10 ¹² particles are introduced. In yet another further embodiment, about 10 ⁸ to about 10 ¹⁰ particles are introduced. In a preferred embodiment, the preferred dose is 0.1% solids/ml. Accordingly, for 0.5 µm beads the preferred dose is about 4 x 10 ⁹ beads, for 0.05 µm beads the preferred dose is about 4 x 10 ¹² beads, for 3 µm beads the preferred dose is 2 x 10 ⁷ beads. However, any dose that is effective for treating the particular condition being treated is included in the present invention.

The present invention is suitable for the treatment of disorders associated with the immune system, such as autoimmune diseases, transplant rejection, enzyme deficiencies and allergic reactions. Substituting a system of synthetic biocompatible particles to induce immune tolerance allows for simplified manufacturing, increased availability of therapeutic agents, increased sample uniformity, increased number of possible treatment sites, and significantly reduced the likelihood of allergic responses to the host cell.

As used herein, the term “immune response” includes immune responses mediated by T cells and/or B cells. Examples of immune responses include T cell responses such as cytokine production and cell-mediated cytotoxicity. In addition, the term “immune response” includes immune responses that are indirectly affected by T cell activation, such as the production of antibodies (humoral responses), and the activation of cytokine-sensitive cells, such as macrophages. Immune cells involved in the immune response include lymphocytes such as B cells and T cells (CD4 ⁺ , CD8 ⁺ , Th1 and Th2 cells); antigen presenting cells (eg, professional antigen presenting cells such as dendritic cells, macrophages, B lymphocytes, Langerhans cells, and non-professional antigen presenting cells such as keratinocytes, endothelial cells, astrocytes, fibroblasts, oligodendrocytes); natural killer cells; myeloid cells such as macrophages, eosinophils, mast cells, basophils and granulocytes. In some embodiments, the modified particles of the present invention effectively reduce the migration of inflammatory cells to the site of inflammation.

As used herein, the term “anergy,” “tolerance,” or “antigen-specific tolerance” refers to the insensitivity of T cells to T cell receptor-mediated stimulation. This insensitivity is essentially antigen-specific and persists after cessation of exposure to the antigenic peptide. For example, in T cells, anergy is characterized by insufficient production of a cytokine such as IL-2. T cell anergy occurs when T cells are exposed to an antigen and receive a first signal (T cell receptor or CD-3 mediated signal) in the absence of a second signal (costimulatory signal). Under these conditions, repeated exposure of cells to the same antigen (even if repeated exposure occurs in the presence of a co-stimulatory molecule) results in the inability to produce cytokines and subsequently in the inability to proliferate. Thus, the inability to produce cytokines prevents proliferation. However, anergic T cells can proliferate if they are cultured with cytokines (eg, IL-2). For example, T cell anergy can also be observed when there is insufficient production of IL-2 by T cells, as measured by ELISA or proliferation assay using an indicator cell line. Alternatively, a reporter gene construct can be used. For example, anergic T cells cannot initiate transcription of DL-2 genes induced by a heterologous promoter under the control of the IL-2 5' gene enhancer or by a multimer with an API sequence that may reside in the enhancer (Kang et al. 1992 Science. 257: 1134) .

As used herein, the term "immunological tolerance" refers to treatments that affect a proportion of treated subjects compared to untreated subjects when there is: a) a decrease in the level of a specific immune response (believed to be at least partially mediated by antigen-specific effector T lymphocytes, B lymphocytes, antibody or equivalents); b) delay in the onset or progression of a specific immune response; or c) reducing the risk of onset or progression of a specific immune response. “Specific” immunological tolerance occurs when immunological tolerance acts preferentially against certain antigens over others. "Nonspecific" immunological tolerance occurs when immunological tolerance is not limited to antigens, leading to an inflammatory immune response. "Quasispecific" immunological tolerance occurs when immunological tolerance acts partially selectively against antigens that lead to a pathogenic immune response, but does not act against those that lead to a protective immune response.

Tolerance to autoantigens and autoimmune disease is achieved through various mechanisms, including negative selection of autoreactive T cells in the thymus, and peripheral tolerance mechanisms for those autoreactive T cells that have escaped deletion in the thymus and are found in the periphery. Examples of mechanisms mediating peripheral T cell tolerance include “ignoring” self-antigens, anergy or unresponsiveness to self-antigen, immune rejection of cytokines, and activation-induced death of self-reactive T cells. In addition, regulatory T cells have been shown to be involved in mediating peripheral tolerance. See, for example, Walker et al. (2002) Nat. Rev. Immunol. 2: 11-19; Shevach et al. (2001) Immunol. Rev. 182: 58-67. In some situations, peripheral tolerance to the autoantigen is lost (or broken) and an autoimmune response ensues. For example, in an animal model of EAE, activation of antigen presenting cells (APCs) through innate immune receptors TLRs has been shown to disrupt self-tolerance and induce EAE (Waldner et al. (2004) J. Clin. Invest. 113: 990-997).

Accordingly, in some embodiments, the invention provides methods for increasing the presentation of antigens while suppressing or reducing stimulation of TLR7/8, TLR9 and/or TLR7/8/9 dependent cells. As described herein, administration of specific modified particles results in the presentation of antigens by DCs or APCs along with suppression of TLR7/8, TLR9 and/or TLR7/8/9-dependent cell responses that are associated with immunostimulatory polynucleotides. Such suppression may include reducing the levels of one or more TLR-associated cytokines.

As described above, the present invention provides new compounds with biological properties suitable for the treatment of Mac-1 and LFA-1 mediated disorders.

Accordingly, in another aspect of the present invention are provided pharmaceutical compositions that contain immunomodifying particles and optionally contain a pharmaceutically acceptable carrier. In certain embodiments, such compositions optionally further contain one or more additional therapeutic agents. Alternatively, the modified particles of the present invention may be administered to a patient in need of treatment in combination with the administration of one or more therapeutic agents. For example, additional therapeutic agents to be coadministered or included in a pharmaceutical composition with a compound of the present invention may be an approved anti-inflammatory agent or any of a number of agents undergoing FDA approval that will ultimately be approved for use. treatment of any disorder characterized by an uncontrolled inflammatory immune response, or bacterial or viral infection. It should also be understood that some of the modified particles of the present invention may exist in free form for treatment or, as appropriate, in the form of a pharmaceutically acceptable derivative thereof.

The pharmaceutical compositions of the present invention further contain a pharmaceutically acceptable carrier, which in the present invention includes any and all solvents, diluents or other liquid carrier, dispersion or suspension auxiliaries, surfactants, isotonic agents, thickeners or emulsifiers, preservatives, solid binders, lubricants, etc., which can be used to obtain the specific dosage form required. Remington's Pharmaceutical Sciences, Sixteenth Edition, E. W. Martin (Mack Publishing Co., Easton, Pa., 1980) describes various carriers that are used in the formulation of pharmaceutical compositions and known techniques for their preparation. Except to the extent that any generally known carrier medium is found to be incompatible with the compounds of the invention, for example due to the production of any undesirable biological effect or other adverse interaction with any other component(s) of the pharmaceutical composition, its application is considered part of the scope of the present invention. Some examples of materials that can serve as pharmaceutically acceptable carriers include, but are not limited to, sugars such as lactose, glucose and sucrose; starches such as corn starch and potato starch; cellulose and its derivatives such as sodium carboxymethylcellulose, ethylcellulose and cellulose acetate; powdered tragacanth; malt; gelatin; talc; excipients such as cocoa butter and suppository waxes; oils such as peanut oil, cottonseed oil, safflower oil, sesame oil, olive oil, corn oil and soybean oil; glycols such as propylene glycol; esters such as ethyl oleate and ethyl laurate; agar; buffering agents such as magnesium hydroxide and aluminum hydroxide; alginic acid; pyrogen-free water; isotonic solution; Ringer's solution; ethyl alcohol and phosphate buffer solutions; and other non-toxic compatible lubricants such as sodium lauryl sulfate and magnesium stearate. At the discretion of the formulator, the composition may also contain coloring agents, releasing agents, coating agents, sweeteners, flavoring agents, preservatives and antioxidants.

Liquid dosage forms for oral administration include, but are not limited to, pharmaceutically acceptable emulsions, microemulsions, solutions, suspensions, syrups and elixirs. In addition to the active compounds, liquid dosage forms may contain inert diluents that are commonly used in the art, such as, for example, water or other solvents, solubilizing agents and emulsifiers, such as, for example, ethyl alcohol, isopropyl alcohol, ethyl carbonate, ethyl acetate, benzyl alcohol , benzyl benzoate, propylene glycol, 1,3-butylene glycol, dimethylformamide, oils (especially cottonseed, peanut, corn, wheat germ, olive, castor and sesame oils), glycerin, tetrahydrofurfuryl alcohol, polyethylene glycols and sorbitan fatty acid esters, as well as their mixtures. In addition to inert diluents, oral compositions may also include adjuvants such as wetting agents, emulsifiers and suspending agents, sweeteners, flavoring agents and flavoring agents.

The particles of the present invention can be administered orally, nasally, intravenously, intramuscularly, intraocularly, transdermally, intraperitoneally or subcutaneously. In one embodiment, the particles of the invention are administered intravenously.

The effective amount and route of administration of the present invention to modulate the immune response may vary depending on the subject, the condition being treated, and other factors known to those skilled in the art. Factors to consider include the route of administration and the number of doses administered. Such factors are known in the art and can be successfully determined by those skilled in the art without undue experimentation. A suitable dosage range is one that provides the desired regulation of the immune response. A suitable dosage range of the vehicle, indicated in the amount of vehicle produced, may be any of the following: 0.5 to 10 mg/kg, 1 to 9 mg/kg, 2 to 8 mg/kg, 3 to 7 mg/kg. kg, from 4 to 6 mg/kg, 5 mg/kg, from 1 to 10 mg/kg, from 5 to 10 mg/kg. Alternatively, the dosage may be determined based on the number of particles. For example, a suitable carrier dosage range, indicated by the amount of carrier produced, may be, for example, about 10 ⁶ , 10 ⁷ , 10 ⁸ , 10 ⁹ , 10 ¹⁰ or more particles per dose. The absolute amount given to each patient depends on pharmacological properties such as bioavailability, clearance and route of administration. Detailed information regarding pharmaceutically acceptable carriers, diluents and excipients, as well as methods for preparing pharmaceutical compositions and formulations, is provided in Remmingtons Pharmaceutical Sciences ^18th Edition, 1990, Mack Publishing Co., Easton, Pa., USA., which is incorporated herein in its entirety by links.

The effective amount and route of administration of a particular carrier formulation may vary depending on the individual patient, the desired outcome and/or type of disorder, the stage of the disease, and other factors apparent to one skilled in the art. The method(s) of administration that may be used in a particular application will be apparent to one skilled in the art. Routes of administration include, but are not limited to, topical, dermal, transdermal, transmucosal, epidermal, parenteral, gastrointestinal, nasopharyngeal and pulmonary, including transbronchial and transalveolar routes. A suitable dosage range is one that provides delivery of the immunoregulatory particle composition sufficient to achieve a tissue concentration of about 1-50 μM, as measured by blood levels. The absolute amount given to each patient depends on pharmacological properties such as bioavailability, clearance and route of administration.

The present invention provides carrier compositions suitable for topical use, including, without limitation, physiologically acceptable implants, ointments, creams, rinses and gels. Examples of dermal administration methods include methods less invasive than transdermal transfer, epidermal administration, and subcutaneous injection.

Transdermal administration is carried out by applying a cream, rinse, gel, etc., capable of allowing the carrier to penetrate the skin and enter the bloodstream. Compositions suitable for transdermal administration include, but are not limited to, pharmaceutically acceptable suspensions, oils, creams and ointments applied directly to the skin or enclosed in a protective carrier such as a transdermal device (called a "patch"). Examples of suitable creams, ointments, etc. can be found, for example, in a doctor's desk reference. Transdermal transfer can also be accomplished by iontophoresis, for example using commercially available patches that continuously deliver the product they contain through intact skin for several days or more. The use of this method allows for the controlled delivery of pharmaceutical compositions in relatively high concentrations, allows the administration of drug combinations and allows the simultaneous use of an absorption promoter.

Parenteral route of administration includes, but is not limited to, electrical route (iontophoresis) or direct injection route, such as direct injection into a central intravenous line, intravenous, intramuscular, intraperitoneal, intradermal, or subcutaneous injection. Carrier formulations suitable for parenteral administration are substantially formulated in USP-compliant water or water for injection, and may further contain pH buffers, saline excipients, preservatives and other pharmaceutically acceptable excipients. The immunoregulatory polynucleotide for parenteral administration can be prepared in pharmaceutically acceptable sterile isotonic solutions such as saline or phosphate-buffered saline for injection.

Gastrointestinal routes of administration include, but are not limited to, dietary and rectal routes and may include, for example, pharmaceutically acceptable oral powders, pills or liquids and rectal suppositories.

The nasopharyngeal and pulmonary routes of administration are carried out by inhalation, and in this case, delivery methods such as intranasal, transbronchial and transalveolar routes may be implied. The invention includes carrier compositions suitable for administration by inhalation, including, but not limited to, liquid suspensions for creating aerosols, as well as powder forms for dry powder inhalation delivery systems. Devices suitable for administering carrier formulations by inhalation include, but are not limited to, nebulizers, vaporizers, nebulizers, and dry powder inhalation delivery systems.

Injectable preparations, such as sterile aqueous or oleaginous injectable suspensions, can be prepared according to principles known in the art using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution, suspension or emulsion in a non-toxic diluent or solvent suitable for parenteral administration, for example a solution in 1,3-butanediol. Acceptable carriers and solvents that may be used are water, Ringer's solution, and isotonic sodium chloride solution of pharmaceutical grade (USP). In addition, sterile non-volatile oils are traditionally used as a solvent or suspending medium. Any soft, fixed oil can be used for this purpose, including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid are used to obtain injection preparations.

Injectable formulations can be sterilized, for example, by filtration through a bacteria-retaining filter or by incorporating sterilizing agents in the form of sterile solid compositions that can be dissolved or dispersed in sterile water or other sterile injectable media prior to use.

To prolong the effect of a drug, it is often desirable to slow the absorption of the drug by subcutaneous or intramuscular injection. This can be achieved by using a liquid suspension or a crystalline or amorphous material with low water solubility. In this case, the rate of absorption of the drug depends on the rate of its dissolution, which in turn may depend on the size of the crystals and crystalline form. Alternatively, prolonged absorption of a parenterally administered form of a drug is achieved by dissolving or suspending the drug in an oily vehicle. Injection depot forms are prepared by forming microencapsulated drug matrices in biodegradable polymers such as polylactide-polyglycolide. By varying the ratio of drug to polymer and the properties of the particular polymer used, the rate of drug release can be controlled. Examples of other biodegradable polymers include poly(orthoesters) and poly(anhydrides). Injection depot formulations are also prepared by incorporating the drug into liposomes or microemulsions compatible with body tissues.

In some embodiments, the synthetic biodegradable particles of the present invention provide ease of manufacture, widespread availability of therapeutic agents, and increased treatment site. In specific embodiments, biodegradable surface-functionalized lactide-glycolide copolymer particles having a high density of carboxyl groups on the surface, synthesized using the surfactant poly(ethylene-alt-maleic anhydride), provide a carrier having many advantages over other carrier particles and/or surfaces. Experiments conducted in developing embodiments of the present invention have demonstrated the conjugation of peptides (eg, PLP _139-151 peptide) to these particles. Such peptide-linked particles have been shown to be effective in preventing disease progression and inducing immunological tolerance (eg, in R-EAE, a murine model of multiple sclerosis induced in SJL/J mice by PLP _139-151 /CFA). The peptide-linked carriers of the present invention have many advantages over other tolerance-inducing structures. In some embodiments, the particles are biodegradable and therefore will not be present in the body for a long time. The time for complete decomposition can be controlled. In some embodiments, the particles are functionalized to facilitate internalization without cellular activation (eg, loading phosphatidylserine into PLG microspheres). In some embodiments, ligands are incorporated into the particles to target them to a specific population of cells. In some embodiments, anti-inflammatory cytokines, such as IL-10 and TGF-β, are included on or within the particles to limit activation of the cell type internalizing the particles and facilitate the induction of tolerance through energy and/or killing, as well as the activation of regulatory T cells . Particle composition has been found to influence how long particles remain in the body, and rapid particle uptake and rapid clearance/degradation are required for tolerance induction. Since a lactide:glycolide ratio greater than 50:50 reduces the rate of degradation, the particles of the invention have a lactide:glycolide ratio of about 50:50 or less. In one embodiment, the particles of the invention have a D,L-lactide:glycolide ratio of about 50:50.

Solid dosage forms for oral administration include capsules, tablets, pills, powders and granules. In such solid dosage forms, the modified particles are mixed with at least one inert pharmaceutically acceptable excipient or carrier such as sodium citrate or dicalcium phosphate and/or a) fillers or diluents such as starches, lactose, sucrose, glucose, mannitol and silicic acid, b) binders such as carboxymethylcellulose, alginates, gelatin, polyvinylpyrrolidone, sucrose and gum arabic, c) humectants such as glycerin, d) disintegrants such as agar-agar, calcium carbonate, potato or cassava starch, alginic acid, some silicates and sodium carbonate, e) dissolution retarders such as paraffin, f) absorption accelerators such as quaternary ammonium compounds, g) wetting agents such as, for example, cetyl alcohol and glycerol monostearate, h) absorbents such as kaolin and bentonite clay , and i) lubricants such as talc, calcium stearate, magnesium stearate, solid polyethylene glycols, sodium lauryl sulfate, and mixtures thereof. In the case of capsules, tablets and pills, the dosage form may also contain buffering agents.

Solid compositions of a similar type can also be used as fillers in soft- and hard-filled gelatin capsules using excipients such as lactose or milk sugar, as well as high molecular weight polyethylene glycols, etc. Solid dosage forms of tablets, dragees, capsules, pills and granules can prepare using coatings and coatings, such as enteric and other coatings well known in the art of preparing pharmaceutical compositions. They may optionally contain opacifying agents and may also be formulated to release the active component(s) only or preferentially in a specific part of the digestive tract, optionally in a delayed form. Examples of possible encapsulating compositions include polymeric substances and waxes. Solid compositions of a similar type can also be used as fillers in soft- and hard-filled gelatin capsules using excipients such as lactose or milk sugar, high molecular weight polyethylene glycols, etc.

The modified particles can also be prepared in microencapsulated form with one or more of the excipients listed above. Solid dosage forms of tablets, dragees, capsules, pills and granules can be prepared using coatings and coatings, such as enteric coatings, controlled release coatings and other coatings well known in the art of preparing pharmaceutical compositions. In such solid dosage forms, the active compound can be mixed with at least one inert diluent, such as sucrose, lactose and starch. In accordance with conventional practice, such dosage forms may also contain additional substances in addition to inert diluents, for example tableting lubricants and other tabletting aids such as magnesium stearate and microcrystalline cellulose. In the case of capsules, tablets and pills, the dosage forms may also contain buffering agents. They may optionally contain opalescent agents and may also be formulated to release the modified particles only or preferentially in a specific part of the digestive tract, optionally in a delayed manner. Examples of possible encapsulating compositions include polymeric substances and waxes.

The present invention includes pharmaceutically acceptable topical formulations of modified particles having the features of the invention. As used herein, the term “pharmaceutically acceptable topical formulation” means any formulation that is pharmaceutically acceptable for intradermal administration of the modified microparticles of the invention by application of the compound to the epidermis. In some embodiments of the present invention, the topical composition comprises a carrier system. Pharmaceutically effective carriers include, but are not limited to, solvents (e.g., alcohols, polymer alcohols, water), creams, lotions, ointments, oils, patches, liposomes, powders, emulsions, microemulsions, and buffer solutions (e.g., hypotonic or buffered saline) or any other carrier known in the art to be used for administering topical medications. A more complete list of carriers known in the art is provided by reference in standard reference literature, for example, Remington's Pharmaceutical Sciences, ^16th Edition, 1980 and ^17th Edition, 1985, both published by Mack Publishing Company, Easton, Pennsylvania, the descriptions of which are incorporated herein by reference in their entirety. In some other embodiments, the topical compositions of the invention may contain excipients. Any pharmaceutically acceptable excipients known in the art can be used to prepare pharmaceutically acceptable topical compositions having the features of the invention. Examples of excipients that may be included in the topical formulations of the invention include, but are not limited to, preservatives, antioxidants, humectants, emollients, buffering agents, solubilizing agents, other permeability agents, skin protectants, surfactants and propellants and/or additional therapeutic agents used in combination with modified particles. Suitable preservatives include, but are not limited to, alcohols, quaternary amines, organic acids, parabens and phenols. Suitable antioxidants include, but are not limited to, ascorbic acid and its esters, sodium bisulfite, butylated hydroxytoluene, butylated hydroxyanisole, tocopherols, and chelating agents such as EDTA and citric acid. Suitable humectants include, but are not limited to, glycerin, sorbitol, polyethylene glycols, urea and propylene glycol. Suitable buffering agents for use in the invention include, but are not limited to, citric acid, hydrochloric acid and lactic acid buffers. Suitable solubilizing agents include, but are not limited to, quaternary ammonium chlorides, cyclodextrins, benzyl benzoate, lecithin and polysorbates. Suitable skin protectants that may be used in the topical formulations of the invention include, but are not limited to, oil containing vitamin E, allantoin, dimethicone, glycerin, petrolatum and zinc oxide.

In certain embodiments, the pharmaceutically acceptable topical formulations of the invention contain at least the modified particles of the invention and a penetration enhancing agent. The choice of topical formulation will depend on several factors, including the condition being treated, the physicochemical characteristics of the inventive compound and other excipients present, their stability in the formulation, available manufacturing equipment, and cost constraints. As used herein, the term "permeation enhancing agent" means an agent capable of transporting a pharmacologically active compound through the stratum corneum into the epidermis or dermis, preferably with little or no systemic absorption. A wide variety of compounds have been evaluated for their effectiveness in enhancing the rate of drug penetration through the skin. See, for example, Percutaneous Penetration Enhancers, Maibach H. I. and Smith H. E. (eds.), CRC Press, Inc., Boca Raton, Fla. (1995), which evaluates the use and testing of various skin permeation enhancers, and Buyuktimkin et al., Chemical Means of Transdermal Drug Permeation Enhancement in Transdermal and Topical Drug Delivery Systems, Gosh T. K., Pfister W. R., Yum S. I. (Eds.), Interpharm Press Inc., Buffalo Grove, Ill. (1997). In some embodiments, penetration enhancing agents for use in the present invention include, but are not limited to, triglycerides (e.g., soybean oil), aloe compositions (e.g., aloe vera gel), ethyl alcohol, isopropyl alcohol, octoliphenyl polyethylene glycol, oleic acid, polyethylene glycol 400, propylene glycol, N-decyl methyl sulfoxide, fatty acid esters (eg isopropyl myristate, methyl laurate, glycerol monooleate and propylene glycol monooleate) and N-methylpyrrolidone.

In certain embodiments, the compositions may be presented in the form of ointments, pastes, creams, lotions, gels, powders, solutions, aerosols, inhalants, or patches. In some exemplary embodiments, the formulations of the compositions according to the invention are creams which may further contain saturated or unsaturated fatty acids such as stearic acid, palmitic acid, oleic acid, palmitooleic acid, cetyl or oleyl alcohols, with particular preference being given to is stearic acid. The creams of the invention may also contain a non-ionic surfactant, for example polyoxy-40-stearate. In certain embodiments, the active ingredient is mixed under sterile conditions with a pharmaceutically acceptable carrier and any necessary preservatives or buffer solutions. It is believed that ophthalmic compositions, ear drops and eye drops are also included within the scope of the invention. In addition, the present invention provides for the use of transdermal patches, which have the additional advantage of providing controlled delivery of the compound to the body. Such dosage forms are prepared by dissolving or dispersing the compound in an appropriate medium. As described above, permeation enhancing agents can also be used to increase the flux of a compound through the skin. The rate of permeation can be controlled by either providing a membrane that controls the rate of permeation or dispersing the compound in a polymer matrix or gel.

The modified particles can be administered via aerosol. This is achieved by producing an aqueous aerosol, liposomal preparation or solid particles containing modified particles. An anhydrous suspension (eg fluorocarbon propellant) can be used.

Typically, an aqueous aerosol is prepared by formulating an aqueous solution or suspension of the agent together with conventional pharmaceutically acceptable carriers and stabilizers. Carriers and stabilizers vary depending on the requirements of a particular compound, but typically include nonionic surfactants (Tweens, Pluronics® or polyethylene glycol), non-toxic proteins such as serum albumin, sorbitol esters, oleic acid, lecithin, amino acids, such as glycine, buffers, salts, sugars or sugar alcohols. Aerosols are essentially prepared from isotonic solutions.

It should also be understood that the modified particles and pharmaceutical compositions of the present invention can be prepared and used in combination therapies, i.e., the compounds and pharmaceutical compositions can be formulated in admixture with, or administered simultaneously with, before, or after one or more other required therapeutic agents or medical procedures. When selecting a particular therapeutic combination (therapeutic agents or procedures) for use in a combination treatment regimen, the compatibility of the therapeutic agents and/or procedures required and the desired therapeutic effect to be achieved will be taken into account. It should also be understood that the therapeutic agents used may achieve the desired effect on the same disorder (eg, a compound of the invention may be administered concomitantly with another anti-inflammatory agent), or they may achieve different effects (eg, control of any adverse side effects).

In certain embodiments, pharmaceutical compositions containing the modified particles of the present invention further contain one or more additional therapeutically active components (eg, anti-inflammatory and/or palliative components). For purposes of the invention, the term "palliative" refers to treatment that focuses on relieving the symptoms of a disease and/or the side effects of a treatment regimen, but is not curative. For example, palliative care includes painkillers, antiemetic medications, and antinausea medications.

The invention provides methods for regulating the immune response in a subject, preferably a mammal, more preferably a human, comprising administering to the subject the modified particles described herein. The immunoregulatory methods provided by the present invention include those that suppress and/or inhibit the innate immune response or the adaptive immune response, including, without limitation, the immune response stimulated by immunostimulatory polypeptides or viral or bacterial components.

The modified particles are administered in an amount sufficient to regulate the immune response. As described herein, regulation of the immune response can be humoral and/or cellular and is measured using standard techniques known in the art and described herein.

In some embodiments, the compositions described herein are administered together (e.g., concurrently, before or after) with an implant (e.g., device) and/or graft (e.g., tissue, cells, organ) to mediate, neutralize, regulate and/ or a decrease in the corresponding immune response.

In certain embodiments, the subject suffers from a disorder associated with unwanted immune activation, such as an allergic disease or condition, allergies and asthma. A subject with an allergic disease or asthma is a subject with a detectable symptom of an existing allergic disease or asthma. In such a subject, tolerance can be induced, for example, by using particles complexed with certain foods (eg, peanut proteins, etc.), injected proteins (eg, bee venom proteins, etc.) or administered by inhalation substances (for example, ragweed pollen proteins, proteins found in the skin cells of pets, etc.) that cause an allergic reaction.

In certain embodiments, the subject suffers from a disorder associated with unwanted immune activation, such as an autoimmune disease and an inflammatory disease. A subject with an autoimmune disease or inflammatory disease is a subject with a detectable symptom of an existing autoimmune disease or inflammatory disease. In such a subject, tolerance can be developed, for example, using particles in combination with the corresponding autoantigens that cause a particular autoimmune disease.

In certain embodiments, the subject suffers from a disorder associated with enzyme replacement therapy. In such a subject, tolerance can be induced, for example, by particles complexed with enzymes that patients with a genetic deficiency are unable to produce, to prevent them from developing neutralizing antibodies to recombinant enzymes administered to treat the deficiency, for example, tolerance to human factor VIII in patients with hemophilia, caused by a genetic deficiency in the ability to produce factor VIII. Another example may include enzyme replacement in conditions such as mucopolysaccharide storage disease, gangliosidosis, alkaline hypophosphatasia, cholesteryl ester storage disease, hyperuricemia, growth hormone deficiency, renal anemia, or with lysosomal storage diseases including Fabry disease, Gaucher disease, Hurler disease, Hunter disease, Maroteau-Lamy disease, Niemann-Pick disease, Tay-Sachs disease and Pompe disease.

In certain embodiments, the subject suffers from a potent or otherwise adverse immune response to the agent administered to treat the disease, thereby actually or potentially compromising the patient's health or treatment. In addition, the novel compounds of the invention may be administered to subjects who have not demonstrated an immune response to an agent but may potentially develop one in the future. In certain embodiments, the subject receives enzyme replacement therapy. In certain embodiments, therapeutic agents include, but are not limited to, peptides or protein-based agents, DNA vaccines, siRNA, splice site switching oligomers, and RNA-based nanoparticles. In some embodiments, the therapeutic agents include, but are not limited to, advat, antihemophilic factor, cogenate, eloctate, recombinant factor VIII-Fc fusion protein, refacto, Novo VIIa, recombinant factor VII, eptacog alpha, helixate, monanin, coagulation factor IX, vilate, ceredase, agglucerase, cerezim, imiglucerase, Elelso, taliglucerase alfa, fabrazyme, agalsidase beta, aldurazim, alpha-L-iduronidase, myozyme, acid glucosidase, elaprase, iduronate-2-sulfatase, naglazyme arylsulfatase B and N-acetylgalactosamine-4 -sulfatase. In some embodiments, the subject is administered therapeutic agents used to treat diseases including, but not limited to, hemophilia, hemophilia A, hemophilia B, von Willebrand disease, Gaucher disease, Fabry disease, Hurler disease, Pompe disease, Hunter disease, mucopolysaccharide storage disease, gangliosidosis, alkaline hypophosphatasia, cholesteryl ester storage disease, hyperuricemia, growth hormone deficiency, renal anemia and Maroteaux-Lamy disease.

In certain embodiments, the subject suffers from an orphan autoimmune condition. Such conditions include, but are not limited to, idiopathic thrombocytopenic purpura, membranous nephropathy, bullous pemphigoid, pemphigus vulgaris and myasthenia gravis.

In certain embodiments, the subject is suffering from a treatment-related disorder. In the case of recombinant antibodies, tolerance is induced, for example, to a humanized antibody used in a therapeutic context to prevent the patient from developing neutralizing antibodies to therapeutic antibodies, for example, tolerance is induced to a humanized antibody that eliminates an immune subpopulation, or to an antibody to a cytokine used for treatment autoimmune disease.

Autoimmune diseases can be divided into two broad categories: organ-specific and systemic. Autoimmune diseases include, but are not limited to, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes mellitus type I, diabetes mellitus type II, multiple sclerosis (MS), immune-mediated infertility such as premature ovarian failure, scleroderma, disease Sjögren's disease, vitiligo, alopecia (baldness), polyglandular deficiency, Graves' disease, hypothyroidism, polymyositis, pemphigus vulgaris, pemphigus foliaceus, inflammatory bowel disease, including Crohn's disease and ulcerative colitis, autoimmune hepatitis, including those associated with hepatitis B virus (HBV) and hepatitis C (HCV), hypopituitarism, graft-versus-host disease (GvHD), myocarditis, Addison's disease, autoimmune skin diseases, uveitis, pernicious anemia, celiac disease, hypoparathyroidism, neuromyelitis optica, membranous nephropathy, bullous pemphigoid, pemphigus vulgaris, myasthenia gravis.

Autoimmune diseases may also include, but are not limited to, Hashimoto's thyroiditis, autoimmune polyglandular syndromes type I and type II, paraneoplastic pemphigus, bullous pemphigus, dermatitis herpetiformis, linear IgA dermatosis, epidermolysis bullosa acquisita, erythema nodosum, pemphigoid of pregnancy, cicatricial pemphigoid, essential cryoglobulinemia of mixed type, chronic bullous disease of childhood, hemolytic anemia, thrombocytopenic purpura, Goodpasture's syndrome, autoimmune neutropenia, myasthenia gravis, Eaton-Lambert myasthenic syndrome, muscle stiffness syndrome, acute disseminated encephalomyelitis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, multi focal motor neuropathy with conduction block, chronic neuropathy with monoclonal gammopathy, opsoclonic-myoclonic syndrome, cerebellar degeneration, encephalomyelitis, retinopathy, primary biliary sclerosis, sclerosing cholangitis, gluten-dependent enteropathy, ankylosing spondylitis, reactive arthritis, polymyositis/dermatomyositis, mixed disease connective tissue syndrome Behcet's, psoriasis, polyarteritis nodosa, allergic angiitis and granulomatosis (Churg-Strauss disease), overlap polyangiitis syndrome, allergic vasculitis, Wegener's granulomatosis, temporal arteritis, Takayasu arteritis, Kawasaki disease, isolated vasculitis of the central nervous system, thromboangiitis obliterans, sarcoidosis , glomerulonephritis and cryopathies. These conditions are well known in the medical field and are described, for example, in Harrison's Principles of Internal Medicine, ^14th ed., Fauci AS et al., eds., New York: McGraw-Hill, 1998.

Animal models for studying autoimmune disease are known in the art. For example, the animal models most similar to human autoimmune diseases involve animal strains that spontaneously develop a particular disease at high rates. Examples of such models include, but are not limited to, non-obese diabetic (NOD) mice that develop a disease similar to type I diabetes, as well as animals susceptible to a disease similar to systemic lupus erythematosus, such as New Zealand hybrids, MRL-Fas ^lpr and BXSB mice. Animal models of induced autoimmune disease include, but are not limited to, the experimental autoimmune encephalomyelitis (EAE) model, which is a model of multiple sclerosis, collagen-induced arthritis (CIA), which is a model of rheumatoid arthritis, T-cell transgenic mice, specific for desmoglein 3, used as an experimental model of pemphigus vulgaris, and the experimental autoimmune uveitis (EAU) model, which is a model of uveitis. Animal models of autoimmune disease have also been generated through genetic manipulation and include, for example, IL-2/IL-10 knockout mice to model inflammatory bowel disease, Fas or Fas ligand knockout mice to model SLE, and antagonist knockout mice. to the IL-I receptor to model rheumatoid arthritis.

In certain embodiments, the subject is suffering from a bacterial or viral infection. A subject with a bacterial or viral infection is a subject with a detectable symptom of an existing bacterial or viral infection.

A non-limiting list of viral infections treatable with the modified particles of the present invention includes herpes simplex virus infections, hepatitis virus infections, West Nile virus infections, flavivirus infections, influenza virus infections, rhinovirus infections, human papillomavirus infections, paromyxovirus infections, parainfluenza virus infections, and retroviral infections. Preferred viruses are those that infect the central nervous system of the subject. The most preferred viruses are those that cause hemorrhagic fever, encephalitis or meningitis.

A non-limiting list of bacterial infections treatable with the modified particles of the present invention includes staphylococcal infections, streptococcal infections, mycobacterial infections, bacilli infections, salmonella infections, vibrio infections, spirochete infections, and infections caused by caused by Neisseria. Preferred bacteria are those that infect the central nervous system of the subject. The most preferred bacteria are those that cause encephalitis or meningitis.

In some embodiments, the invention relates to the use of the compositions of the present invention before the onset of a disease. In other embodiments, the invention relates to the use of the compositions of the present invention to inhibit an ongoing disease. In some embodiments, the invention relates to alleviating a disease in a subject. Alleviating a disease in a subject means providing treatment, prevention, or suppression of a disease in a subject.

In some embodiments, the invention relates to preventing the recurrence of a disease. For example, an unwanted immune response may develop to one region of the peptide (eg, an antigenic determinant). Relapse of the disease associated with an unwanted immune response may develop due to the occurrence of an immune response to another region of the peptide. Since the immunomodifying particles of the present invention do not have peptides or antigenic fragments attached to them, the particles will be effective against a variety of epitopes. In some immune response disorders, including MS and other Th1/17-mediated autoimmune diseases, T cell responses can be dynamic and evolve during relapsing-remitting and/or chronic progressive disease. The dynamic nature of the T cell repertoire has implications for the treatment of some diseases, since the target may change as the disease progresses. Previously, prior knowledge of the nature of immune responses was necessary to predict disease progression. The present invention provides compositions that can prevent the dynamic disease changing effect of the epitope spreading phenomenon. A well-known model of disease relapse is the immune response to proteolipid protein (PLP), which serves as a model of multiple sclerosis (MS). The initial immune response may occur in response to PLP139-15. Subsequent onset of disease may result from a relapse of the immune response to PLP[pi]s-iβi.

Other embodiments of the present invention relate to transplantation. It refers to the transfer of a tissue sample or graft from a donor subject to a recipient subject and is often performed on human recipients who require the tissue to restore the physiological function provided by the tissue. Transplanted tissues include (but are not limited to) whole organs such as kidney, liver, heart, lung; organ components such as skin grafts and corneas; and cell suspensions, such as bone marrow cells and cultures of cells collected and expanded from bone marrow or circulating blood, and whole blood transfusions.

A major potential complication of any transplantation occurs due to antigenic differences between the recipient host and the transplanted tissue. Depending on the nature and extent of the differences, there may be a risk of immunological attack by the host on the graft, or the graft on the host, or both. The degree of risk is determined by observing the response pattern in a population of subjects of a similar phenotype receiving similar treatment and by correlating various possible influencing factors, in accordance with accepted clinical procedures. The immunological attack may be the result of a pre-existing immune response (eg, preformed antibody) or a response that is initiated shortly after transplantation (eg, generation of Th cells). Antibody, Th cells, or Tc cells can participate in the immune response in any combination with each other and with a variety of effector molecules and cells. However, the antigens that participate in the immune response are essentially unknown, so there are difficulties in developing antigen-specific therapies or inducing antigen-specific tolerance.

Some embodiments of the invention relate to reducing the risk of host-versus-graft disease in a disease leading to tissue graft rejection by the recipient. Treatment can be administered to prevent or reduce the effect of a hyperacute, acute or chronic graft rejection response. Treatment should preferably be started sufficiently in advance of transplantation so that tolerance has already been achieved by the time of transplantation; but in cases where this is not possible, treatment can be started at the same time as or after the transplant. Regardless of the time of initiation, treatment is substantially continued at intervals for at least the first month after transplantation. Subsequent doses may not be required if sufficient graft engraftment occurs, but treatment may be restarted if there are any signs of graft rejection or inflammation. Of course, the tolerance-building procedures of the present invention can be combined with other forms of immunosuppression to achieve an even lower degree of risk.

Some embodiments of the invention relate to reducing or otherwise attenuating the inflammatory response induced in response to surgery. In one embodiment of the invention, the immunomodifying particles are administered prior to surgery. In a further embodiment of the invention, the immunomodifying particles are administered simultaneously or during surgery. In yet another further embodiment of the invention, the immunomodifying particles are administered after surgery.

The particles of the present invention can also be used to treat abscesses or empyemas to reduce the inflammatory response generated in a subject after exposure to infectious agents such as bacteria or parasites. In one embodiment of the invention, the immunomodifying particles are administered in combination with antibacterial and/or antiparasitic therapy known in the art.

The particles of the invention can also be used to reduce or otherwise attenuate the inflammatory response induced in response to physical trauma or injury, including, without limitation, sports injury, wound, spinal cord injury, traumatic brain injury and/or soft tissue injury. In one embodiment of the invention, the immunomodifying particles are administered after the subject has suffered trauma or injury.

The particles of the invention can also be used to reduce the inflammatory response associated with the development and/or growth of cancer cells. Cancers treated include, but are not limited to, central nervous system cancer, basal cell carcinoma, brain tumors, Burkitt's lymphoma, lymphoma, cervical cancer, ovarian cancer, testicular cancer, liver cancer, non-small cell and small cell lung cancer, melanoma, bladder cancer, breast cancer, colon and rectal cancer, endometrial cancer, kidney (kidney parenchyma) cancer, leukemia, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, melanoma and thyroid cancer. In one embodiment, subcutaneous injection of particles of the invention prevents the accumulation of inhibitory neutrophils, thereby reducing the immune response in a patient suffering from cancer.

The particles of the invention may also be suitable for the regeneration of damaged tissue. In one embodiment, administration of the particles to a patient enhances the regeneration of damaged epithelial cells of the digestive tract. In a further embodiment, the patient suffers from colitis, Crohn's disease or inflammatory bowel disease. In another embodiment, administering particles of the invention to a patient increases the remyelination of neurons. In a further embodiment, the patient suffers from multiple sclerosis.

In some embodiments, the compositions of the present invention (eg, a PLG carrier coupled to an antigenic molecule) can be used with one or more scaffolds, matrices and/or delivery systems (see, for example, US Patent Application No. 2009/0238879; US Patent No. 7,846,466; US Patent No. 7,427,602; US Patent No. 7,029,697; US Patent No. 6,890,556; US Patent No. 6,797,738; US Patent No. 6,281,256, which are incorporated herein by reference in their entirety). In some embodiments, the particles (e.g., antigen-linked PLG particles) are bound, adsorbed, incorporated, conjugated, etc. to a scaffold, matrix, and/or delivery system (e.g., to deliver a chemical/biological material, cell, tissue to a subject and/or organ). In some embodiments, the scaffold, matrix, and/or delivery system (e.g., for delivering a chemical/biological material, cell, tissue, and/or organ to a subject) comprises and/or consists of materials described herein (e.g., PLG conjugated to one or more antigenic peptides).

In some embodiments, microporous scaffolds are provided (eg, for transplanting biological material (eg, cells, tissues, etc.) into a subject). In some embodiments, microporous scaffolds are provided on which agents (eg, extracellular matrix proteins, exendin-4) and biological material (eg, pancreatic islet cells) are present. In some embodiments, the scaffolds are used for the treatment of diseases (eg, type I diabetes) and related methods (eg, diagnostic methods, research methods, drug screening). In some embodiments, scaffolds are provided with antigen-conjugated carriers described herein located on and/or within the scaffold. In some embodiments, the scaffolds are derived from antigen-conjugated materials (eg, antigen-conjugated PLG).

In some embodiments, the scaffold and/or delivery system comprises one or more layers and/or contains one or more chemical and/or biological entities/agents (e.g., proteins, peptide-conjugated particles, small molecules, cells, tissues, etc. .), see, for example, US patent application 2009/0238879, which is incorporated herein by reference in its entirety. In some embodiments, antigen-associated particles are co-administered with a scaffold delivery system to induce immunological tolerance to the scaffold and associated materials. In some embodiments, the microporous scaffold is administered to a subject with the particles described herein located on or within the scaffold. In some embodiments, the antigen-associated particles are coupled to a scaffold delivery system. In some embodiments, the scaffold delivery system comprises antigen-associated particles.

Various modifications, recombinations and variations of the described elements and embodiments will be apparent to those skilled in the art without departing from the spirit and scope of the invention. Although specific embodiments have been described, it should be understood that the claimed invention should not be unduly limited to such embodiments. Indeed, it is intended that various modifications of the described circuits and embodiments obvious to those skilled in the art are intended to be included within the scope of the following claims. For example, in US Patent Applications 2012/0076831, 2002/0045672, 2005/0090008, 2006/0002978 and 2009/0238879 (each of which is incorporated herein by reference in its entirety) and US Patent Nos. 7,846,466; 7,427,602; 7,029,697; 6,890,556; 6,797,738; and 6,281,256 (each of which is incorporated herein by reference in its entirety) set forth specific information, modifications, and variations that find use in the various embodiments described herein.

All publications and patents mentioned in this application and/or listed below are incorporated herein by reference in their entirety.

EXAMPLES

The following examples are provided to further illustrate the advantages and elements of the invention, but are not intended to limit the scope of the present description.

Materials and methods

Generation of chimeric mice

B6.SJL-Ptprc ^a Pep3 ^b /BoyJ (CD45.1) mice, six to eight weeks old, were irradiated with a single dose of 950 rad. Twelve hours later, mice were injected with 10 ⁷ bone marrow cells from C57BL/6-7.2fms-EGFP donors. Mice were given sulfamethoxazole (Sigma Aldrich) and trimethoprim (Sigma Aldrich) in drinking water for 10 days after irradiation. Mice were infected with WNV six weeks after irradiation as described above. Chimerism was monitored by flow cytometry and was consistently 96-99% of cells of donor origin, as previously shown (Getts et al., J Neurochem. 103: 1019, 2007).

Immunohistology

Mice were anesthetized and perfused with 50 ml of sterile PBS. With the exception of the heart, which was processed and embedded in paraffin blocks (Getts et al., J. Neurochem 103: 10919-1030, 2007), all organs were isolated and frozen in small pieces in Optimum Cutting Temperature Compound (OCT; Tissue-Tek, g . Tokyo, Japan). Eight-μm-thick tissue sections were cut using a cryostatic microtome, air-dried overnight, and stored at 80°C until use. Frozen sections were thawed and histological (standard hematoxylin and eosin staining) or immunohistochemical examination was performed (Getts et al., J. Exp Med 205: 2319–2337, 2008). Antibodies to MARCO, SIGN-R1 and SIGLEC-1 (R&D Systems, Minnesota USA), CD68 (Abcam, Massachusetts, USA) and Ki67 (Abcam) were used as indicated. Images were acquired using an Olympus BX-51 microscope with a DP-70 camera and DP manager 2.2.1 software (Olympus, Tokyo, Japan).

Microscopy and image registration

Images were acquired using an Olympus BX-51 microscope (Olympus, Japan) with a DP-70 camera and DP manager 2.2.1 software (Olympus).

Isolation of leukocytes from the brain and liver

As described previously (Getts et al, J Exp Med. 29: 2319, 2007), leukocytes were obtained from the brains of PBS-perfused mice by digesting brain tissue for 60 minutes at 37°C in PBS with deoxyribonuclease (0.005 g/ml; Sigma Aldrich) and collagenase IV (0.05 g/ml; Sigma Aldrich). Digestion was stopped with 10% FCS and the homogenate was passed through a 70 μm nylon sieve (Becton Dickinson, NJ, USA). The pellet obtained after centrifugation for 10 min at 340 x g was resuspended in 30% Percoll (Amersham, Norway) and overlaid with 80% Percoll. Leukocytes were collected from the 30%/80% solution interface after centrifugation at 1140 x g for 25 minutes at room temperature. The same protocol was used to obtain leukocytes from the liver, with tissue weighed before processing.

Isolation of leukocytes from spleen, blood and bone marrow

For flow cytometry analysis, the right femur was dissected and bone marrow cells were washed out using PBS syringes. Femurs and tibias from at least 4 mice were used to isolate bone marrow progenitors. The cell suspension obtained after washing was filtered through a 70 µm cell sieve and centrifuged for 5 min at 340 g. The erythrocytes in the resulting pellet were lysed with NH ₄ Cl erythrocyte lysis buffer (BD Pharm Lyse™; BD Pharmingen) and then centrifuged for 5 min at 340 x g. For peripheral blood, it was collected through a cardiac puncture and immediately transferred into citrate buffer (mMol, Sigma Alrich). The resulting suspension was layered on 70% Percoll and centrifuged at 1140 x g for 20 minutes at room temperature with the brake off. The interface was removed and the cells were washed once in PBS and centrifuged at 340 x g. To isolate spleen leukocytes, it was passed through a 7070 µm cell sieve and centrifuged for 5 min at 340 g. The erythrocytes in the resulting pellet were lysed with NH ₄ Cl erythrocyte lysis buffer (BD Pharm Lyse™; BD Pharmingen) and then centrifuged for 5 min at 340 x g.

Flow cytometry

Cells collected (as described above) from brain, liver, blood, and bone marrow were washed in PBS and blocked with anti-CD16/CD32 antibodies (Biolegend). Viable cells were counted by the trypan blue exclusion method, which typically showed >95% cell viability.

The expression of molecules on the cell surface was measured and sorting was performed on a FACS ARIA instrument (Becton Dickinson) equipped with an argon ion and HeNe laser. Viable populations were isolated using forward and side light scattering, followed by assessment of the degree of their fluorescence using direct isolation. Sorting was performed using specific fluorescence and scattering parameters identifying the population of interest. Sorting stringency was set to a required purity of >98% for bone marrow cell populations.

The resulting FACS data files were analyzed using Flow Jo flow cytometry analysis software (FlowJo, Ashland, OR, USA). Numbers of cell populations of interest were calculated based on percentages obtained from flow cytometry data analysis, as well as absolute cell counts from each organ.

Adoptive transfer

In developing embodiments of the present invention, experiments were conducted to study a second model of active disease, called adoptive transfer. Instead of immunizing animals with the peptide, lymphocytes from the spleens of mice with active disease were transferred to a recipient who subsequently developed the disease. In developing embodiments of the present invention, experiments were conducted to characterize the ability of PLG nanoparticles to deactivate adoptively transferred activated effector cells. Mice treated with particles or splenocytes bound to a control peptide showed an increase in clinical scores starting at day 4. Mice treated with PLG-PLP _139-151 particles on day 2 had an average clinical score of 0 at all but two time points up to day 40, and an average clinical score at these other time points was 0.25.

Multiplex ELISA

The multiplex plate ELISA assay was performed according to the manufacturer's instructions (Quansys Biosciences, Logan, Utah, USA). Briefly, brain, spleen, and liver tissue were homogenized in PBS, cleared by centrifugation at 1000 × g, and stored at −20°C until analysis. Serum samples were also used. Thawed samples and standards were diluted in the provided buffer and 30 μl of each sample was applied to each well containing 16 spots, each containing a capture antibody for a specific soluble protein. The plates were then incubated for 1 hour on an orbital shaker at 120 rpm. The plates were washed 3 times, 30 μl of tracking antibodies was added to each well and incubated for another hour. After 3 washes, streptavidin-HRP was added and incubated for an additional 15 minutes. Then the plates were washed 6 times and the substrate mixture was added. The plates were immediately scanned on a CCD scanner (Kodak, Rochester, NY, USA). Images from the plate were analyzed using Quansys Q-view software (Quansys Biosciences).

Induction and evaluation of experimental autoimmune encephalitis (EAE)

Mice were injected subcutaneously with an emulsion containing 0.1 mg MOG peptide (MEVGWYRSPFSRVVHLYRNGK (SEQ ID NO: 1); Auspep, Parkville, Victoria, Australia; >95%, HPLC purity) and complete Freund's adjuvant containing 2 mg/ml Mycobacterium tuberculosis (Sigma Aldrich). Two days later, mice were injected with 500 μl of pertussis toxin (Sigma Aldrich) intraperitoneally. The mice were monitored for disease progression and scored on the following scale: 1, loss of tail tone and/or weakness of 1 hind leg; 2, weakness of more than one hind leg, gait disturbance; 3, paralysis of 1 limb; 4, paralysis of more than one limb, incontinence; 5, agony.

Statistical data

Graphs were generated and computer statistical analysis was performed using GraphPad Prism and InStat, respectively (both from GraphPad, San Diego, California, USA). Depending on the data, an unpaired two-tailed Student's t-test or one-way analysis of variance with Tukey-Kramer post-test was performed, and a P value < 0.05 was considered significant.

Nonlinear regression (curve fitting) with a second-order polynomial function (Y = A + B*X + C*X^2) was used to analyze the correlation between parameters such as weight loss, infiltration and viral titer.

Example 1

Preparation of negatively charged immunomodifying particles (IMP)

To a solution of poly(ethylene maleic anhydride) (PEMA) in D ₂ O (4 ml, 1% w/v) was added dropwise a solution of lactide-glycolic acid copolymer (PLG) in dichloromethane (DCM) (2 ml, 20 % w/v). The mixture was sonicated on ice at 16 W for 30 s using a VC 30 sonicator. The resulting crude homogenate was then poured into D ₂ O solution (200 ml containing 0.5% w/v PEMA). The homogenized suspension was allowed to stir overnight at speed setting 3.5 using a Bellco Glass, Inc., Bellstir Multi-stir 9 magnetic stirrer (10 W for 10 s, 16 W for 10 s, 16 W for 30 s).

results

After three hours of mixing, particle size analyzes were performed using dynamic light scattering in disposable polystyrene cuvettes:

a. 10 W, 10 s - Z-average = 499.9 nm - PdI = 0.23, peak = 634.5 nm;

b. 16 W, 10 s - Z-average = 528.9 nm - PdI = 0.227, peak = 657.5 nm;

c. 16 W, 30 s - Z-average = 471.6 nm - PdI = 0.228, peak = 580.5 nm;

d. 16 W, 60 s - Z-average = 491.1 nm - PdI = 0.275, peak = 600.8 nm.

After completion of the reaction, the resulting crude suspension was purified.

Cleaning

Fresh _D2O and 10x sodium bicarbonate buffer solution were cooled overnight to 4 °C. Using a 40 μm cell filter, 36 ml of the particle suspension was filtered from each batch into an appropriately labeled 50 ml centrifuge tube containing 4 ml of chilled 10x sodium bicarbonate buffer solution. Approximately 6 such test tubes were obtained from each beaker. All tubes were centrifuged for about 15 minutes at 7000 g and 4 °C and the supernatant was aspirated. Preparation of the suspension was repeated using the above procedure, with as many precipitated particles as possible suspended in 1 ml of cooled D ₂ O.

The resuspended particles were transferred to a new tube containing 4 ml of chilled 10x sodium bicarbonate buffer solution. (Stage 1)

Particle resuspension was repeated until all sedimented particles were successfully resuspended. (Stage 2)

The contents of the 6 centrifuge tubes were then combined into one centrifuge tube (50 ml tube) and the tube was filled with the remaining 40 ml of chilled _D2O . (Wash 1)

The tube was centrifuged for 20 minutes at 7,000 g and 4 ˚C and the supernatant was aspirated.

Steps 1 and 2 and washing 1 of the resulting particles were repeated at least two more times each time. Finally, the resulting precipitated particles were then flash-frozen in liquid nitrogen and lyophilized to dryness in a collector to produce negatively charged IMPs.

In FIG. Figure 1 shows the characterization of surface-functionalized lactide-glycolide copolymer particles by dynamic light scattering analysis. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 2.5 x 10 ⁵ counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a Z-average diameter of 567 nm, a maximum diameter of 670 nm, and a polydispersity coefficient of 0.209.

Table 4 shows the measurement results for surface-functionalized PLG-PEMA particles. The data in the table is typical as each batch is slightly different from the others. However, the numerical data in the table is based on the combination of several batches of particles. The measurements performed on the double emulsion particles are similar to those shown in Table 2.

Table 4. Parameters of surface-functionalized PLG-PEMA particles

Example 2

Administration of antigen-linked PLGA beads prevents relapse of experimental autoimmune encephalitis

PLG nanoparticles were studied using the immunodominant epitope of the proteolipid protein PLP _139-151 (PLG-PLP _139-151 ), which was used to induce tolerance to prevent relapse of experimental autoimmune encephalitis (R-EAE). R-EAE mice were prepared as described above.

The peptides administered to the animals were coupled to particles with an average diameter of 500 nm. Mice received PLP _139-151 -PLGA (N = 5), or OVA _323-339 -PLGA (N = 5), or unconjugated PLGA (N = 5) on day -7 relative to the time of immunization (day 0) . The peak of the disease was usually observed approximately on days 12-14, and the clinical picture of the disease was scored in mice. Particles without the peptide or particles modified with the control peptide OVA _323-339 did not prevent disease induction. However, PLGA particles modified with PLP _139-151 gave a clinical score of 0 (no disease) in all cases, with the exception of low clinical scores of less than 1 observed between days 20 and 30 (Figure 2). . Previous studies with unmodified PLG particles or using polystyrene particles did not result in such effective disease attenuation, with polystyrene particles typically causing an anaphylactic reaction.

In addition, specific inactivation of myelin‐specific CD4 ⁺ T cells was reflected in the absence of a delayed‐type hypersensitivity (DTH) response to both immunizing epitopes of PLP _{139 - 151} . Thus, prophylactic treatment with PLG-PLP _139-151 on day -7 specifically prevented the development of EAE, indicating an increase in the ability of the particles to prevent disease. The score obtained using particles was as good as or better than the score obtained using antigen-bound splenocytes.

The type of particle administered also influenced the development of EAE in the mouse model. Mice received OVA _323-339 -PLS (N = 5), OVA _323-339 -PLGA _PHOSPOREX (N = 5), OVA _323-339 -PLGA _PEMA (N = 5), PLP _139-151 -PLA (N = 5 ), PLP _139-151 -PLGA _PHOSPOREX (N = 5) or PLP _139-151 -PLG _PEMA (N = 5) on day -7 relative to the time of immunization (day 0). The peak of the disease was usually observed approximately on days 12-14, and the clinical picture of the disease was scored in mice. Particles of either composition modified with the control peptide OVA _323-339 did not prevent disease induction. However, PLP _139-151- bound PLG beads were more effective in reducing R-EAE induction than PLP _139-151- bound commercial PLG particles (Phosphorex) or polystyrene particles (Figures 3A and 3B).

Example 3

Intravenous infusion of antigen-bound PLG particles did not cause the anaphylactic reaction-induced temperature drop in animals presensitized with OVA/Alum

Due to the presence of active disease, anaphylactic reaction to antigens is a problem that can lead to immediate death and has been described with polystyrene-associated particles. An anaphylactic reaction is associated with a significant drop in body temperature. To test whether intravenous administration of OVA-PLG would cause an anaphylactic reaction-induced temperature drop in sensitized animals, mice were immunized on day 0 by intraperitoneal injection of 10 μg OVA/Alum. On day 14, mice were immunized again by intraperitoneal injection of 10 μg of OVA/Alum and then tolerance was induced by intravenous administration of OVA-PLG on day 21. On day 28, mice were induced to tolerate by intravenous administration of either OVA-PLG particles or OVA.

As shown in FIG. 4, mice treated with soluble OVA showed a decrease in temperature on day 28 compared to animals treated with OVA-PLG particles. No decrease in body temperature was observed within 1 hour after particle administration.

In FIG. 5 shows that administration of PLP-PLG particles during remission does not cause mortality associated with an anaphylactic reaction. EAE was induced in six to eight week old female SJL/J mice by subcutaneous injection of PLP _139-151 in complete Freund's adjuvant (CFA) and the development of clinical signs of the disease was monitored and recorded (Figure 5B). On day 21 after disease induction, mice received intravenous injections of soluble PLP _139–151 (white squares), soluble OVA _323–339 (white circles), or the same peptides coupled to PLG nanoparticles (shaded). The animals' temperature was monitored and recorded every 10 minutes for 1 hour after injection (Figure 5A).

Example 4

Prophylactic treatment with PLP-PLG particles induced long-term antigen-specific tolerance

Optimal dosage was determined by intravenous administration of increasing concentrations of PLP_139-151-PLG seven days before disease induction and monitored the development of the clinical picture in comparison with SJL/J mice treated with OVA_323-339-PLG (Fig. 6A). Female SJL/J mice aged six to eight weeks were intravenously injected with PLG nanoparticles bound to either PLP_139-151 (squares), or with OVA_323-339 (circles). EAE was induced by subcutaneous injection of PLP_139-151in CFA after 7 days (Fig. 6B), 25 days (Fig. 6C), or 50 days (Fig. 6D). Animals from panel B were monitored for clinical signs of disease for 100 days. In FIG. 6E shows that on day 8 after disease induction, a subpopulation of mice from panel B underwent a delayed-type hypersensitivity (DTH) reaction. Selected representative animals from panel B primed with PLP_139-151/CFA (OVA_323-339-PLG and PLP_139-151-PLG), the priming epitope PLP was applied to the ear as a stimulus_139-151 and control peptide OVA_323-339. After 24 h, ear swelling was determined as an indicator of DTH, subtracting responses observed before stimulation. In FIG. 6F shows that six to eight week old female SJL/J mice were intravenously administered PLG nanoparticles coupled to PLP_178-191(triangle), OVA_323-339(circle) or PLP_139-151(square) or only unbound particles (empty circle) (F). EAE was induced 7 days later by intravenous administration of PLP_178-191 in CFA and monitored for signs of disease at the time points shown.

Example 5

Treatment of relapsed experimental autoimmune encephalitis with antigen-associated particles

In developing embodiments of the present invention, experiments were conducted to investigate the ability of PLG-PLP particles_139-151 to treat rather than prevent a disease, and to determine whether the route of administration influences the development of the disease. Mice were immunized on day 0 using PLP_139-151 and adjuvant. Typically, the maximum clinical score in mice was observed on days 12-14. In this model, mice received PLG-PLP particles on day 10_139-151 or PLG-OVA control particles_323-339, administered intravenously, intraperitoneally, subcutaneously or orally. As shown in FIG. 7, prophylactic tolerance was most effective with intravenous or intraperitoneal administration of PLG-PLP particles_139-151. In animals treated with PLP_139-151-PLG intravenously, the disease did not develop, and at most time points the mean clinical score was 0. These animals were different from animals receiving polystyrene particles with PLP_139-151, among which death from an anaphylactic reaction was observed in > 70% of animals.

Example 6

Tolerance induced by antigen-bound particles inhibits the induction of antigen-specific Th1 and Th17 cell responses during active relapse of experimental autoimmune encephalitis

To determine whether administration of antigen-associated particles inhibits the induction of helper T cells, BALB/c mice were intravenously administered MOG _35-55 -PLG or OVA _323-339 -PLG on day -7. On day 0, mice were subcutaneously injected with OVA _323-339 -PLG particles and complete Freund's adjuvant (CFA). On day 10, the animals were re-stimulated with either MOG _35-55 -PLG particles or OVA _323-339 -PLG particles, and cells from the draining lymph nodes were isolated. On day 10, CPM and levels of IL-17, GM-CSF, IFN-γ, IL-10, and IL-4 were measured. As shown in FIG. 8, administration of OVA _323-339 -PLG particles inhibited Th1 and Th17 responses in treated animals.

Example 7

Tolerance was induced by PLGA particles bound to PLP- _139-151

An additional therapeutic tolerance strategy was carried out by administering PLP _139-151 -PLG or OVA _323-339 -PLG to mice. Histological analysis showed that administration of PLP _139-151 -PLG particles inhibited inflammation and demyelination of the cervical spinal cord. Mice were injected with PLP-PLG or OVA _323-339 -PLG and tissue was collected on day 40. The cervical spinal cord was isolated and sectioned to study the immune response in the central nervous system, which underlies the pathology of R-EAE and multiple sclerosis. In FIG. Figure 9 shows a decrease in immune cell infiltration into the spinal cord in animals treated with PLP _139-151 -PLG, which was more similar to normal tissue than tissue from animals treated with OVA _323-339 -PLG. Animals treated with OVA _323-339 -PLG showed positive staining for CD45, CD4 and CD11b; whereas in animals treated with PLP _139-151 -PLG, staining for these factors was minimal.

Administration of PLP _139-151 -PLG particles also reduced blood-brain barrier (BBB) disruption and macrophage activation in the spinal cord of treated mice. Animals received complete Freund's adjuvant (CFA), OVA _323-339 -PLG particles, or PLP _139-151 -PLG particles. Clinical scores and percentage occurrence of EAE were determined (Figure 10B), and the spinal cord was monitored by in vivo imaging (Figures 10A and 11). The Angiosense system measures vascular leakage in the CNS, and the Prosense system measures activated macrophages (activation of cathepsin leads to cleavage of the reporter, which produces a fluorescent signal). Histograms assign numerical values to the signal strengths observed in brain and spinal cord images.

Tolerance can also be induced by antigen-encapsulated particles. In FIG. 12 shows that administration of PLG particles encapsulated with the PLP _139-151 peptide inhibited the induction of R-EAE in mice. The ability to encapsulate autoantigens allows for the use of complex mixtures of proteins or even organ homogenates and allows for greater antigen coverage and thus more efficient epitope distribution.

Example 8

Tolerance induced by PLGA particles bound to PLP- _139-151 is partially dependent on expansion/activation of regulatory T cells

SJL/J mice were treated with anti-CD25 antibody, a common marker of regulatory T cells (Tregs), on day -9, and then treated with either OVA _323-339 -PLG particles and anti-CD25 antibody or OVA particles on day -7 _323-339 -PLG and control IgG antibody, PLP _139-151 -PLG particles and anti-CD25 antibody, or PLP _139-151 -PLG particles and control IgG antibody. As shown in FIG. 13, animals treated with PLP _139-151 -PLG particles and anti-CD25 antibody exhibited an at times higher mean clinical score than animals treated with PLP _139-151 -PLG particles and a control IgG antibody. This suggests that Treg cells, or at least CD25-expressing T cells, are involved in tolerance induction.

Example 9

Therapeutic tolerance is induced by PLP _139-151 -PLG particles, in active and adoptive EAE

The therapeutic tolerance induced by PLP _139-151 -PLG particles was compared in active and adoptive EAE. Adoptive EAE was induced in six to eight week old female SJL/J mice by adoptive transfer of 2.5 x 10 ⁶ blast cells activated with PLP _139-151 . Mice received intravenous peptide PLP _139-151 (squares) or OVA _323-339 (circles) bound to 500 nm PLG nanoparticles after 2 days (Fig. 14A), 14 days (Fig. 14C), 18 days (Fig. 14E) or 21 days (Fig. 14F) after disease induction. The clinical disease score was determined in comparison with the score after treatment with splenocytes associated with antigen (Fig. 14A). From mice with tolerance induced by PLP _139-151 or OVA _323-339 , the brain and spinal cord were collected on day 42 for histological analysis. Sections taken from mice in panel A were stained for PLP protein and for CD45 (Fig. 14B). Spinal cord sections taken from mice in panel C were stained with Luxol Fast Blue (Figure 14D). Areas of demyelination and cell infiltration are shown by arrows. The results show that tolerance is induced by PLP _139-151 -PLG particles in adoptive EAE mice.

In FIG. 15 are graphs showing the average clinical scores of mice with active EAE and adoptive EAE after treatment with splenocytes (SP) or OVA-conjugated PLG particles._323-339 or PLP_139-151. Mice received intravenous PLP_139-151-SP, PLP_139-151-PLG, or OVA_323-339-SP, or OVA_323-339-PLG, wherein the peptide was associated with 500 nm nanoparticles, 10 days (Fig. 15A) or 2 days (Fig. 15B) after disease induction, and the average clinical score was determined. In both cases, PLP particles_139-151-PLG attenuated the disease, indicating tolerance induction.

Cell infiltration into the central nervous system was also significantly reduced in PLP-PLG-induced tolerance mice. SJL/J mice were intravenously injected with 500 nm PLG nanoparticles bound to PLP _139-151 (squares) or OVA _323-339 (circles) 2 days after induction of EAE by adoptive transfer. At the peak of the disease (day 14), the brain and spinal cord were collected and the number of lymphocytes (Fig. 16B), antigen presenting cells (APC) (Fig. 16C), microglia (Fig. 16D), peripheral dendritic cells (Fig. 16E), myeloid dendritic cells (Figure 16F) and macrophages (Figure 16G). The discrimination strategy for these populations is shown in FIG. 16A. CNS cell preparations were stimulated with PMA and ionomycin 5 hours before intracellular staining for IL-17A and IFN-γ (Figure 16H).

Example 10

Administration of a monoclonal antibody to PD-1 impairs tolerance induction by PLG nanoparticles encapsulating PLP _139-151 in adoptive transfer EAE

To test the effect of anti-PD-1 antibody administration on PLP _139-151- induced tolerance in mice with adoptive EAE, on day 0, mice were injected intravenously with 3 x 10 ⁶ PLP _139-151 activated T cell blasts. On day 2, they received intravenous PLP _139-151 or OVA _323-339 encapsulated in PLG particles with either PBS or anti-PD-1 antibody. On days 4, 6, 8, 10, and 12, all animals received either 250 μg of anti-PD-1 antibody or PBS.

As shown in FIG. 17, administration of the PLP _139-151 peptide encapsulated in a PLG particle induced tolerance when administered to the particle with PBS. However, administration of anti-PD-1 antibody reduces this tolerance.

Example 11

Administration of an agonistic anti-CD40 monoclonal antibody impairs tolerance induction by PLG nanoparticles encapsulating PLP _139-151 in EAE with adoptive transfer in an IL-12-dependent manner

To test the effect of CD40 agonistic antibody administration on PLP _139-151- induced tolerance in mice with adoptive EAE, on day 0, mice were injected intravenously with 3 x 10 ⁶ PLP _139-151 activated T cell blasts. On day 2, mice received the peptide PLP _139-151 or OVA _323-339 encapsulated in PLG particles via intravenous administration. On day 3, animals received control IgG2a antibody, anti-CD40 antibody, or anti-CD40 antibody and anti-IL-12 antibody.

In FIG. 18 shows that administration of the PLP _139-151 peptide encapsulated in a PLG particle induces tolerance when administered to the particle with PBS. Administration of an agonistic anti-CD40 antibody reduced this tolerance, but the reduction in tolerance was reversed by the addition of an anti-IL-12 antibody.

Example 12

OVA peptide encapsulated in PLG particles, when administered prophylactically, inhibits allergic airway inflammation and OVA-specific Th2 responses in vivo

To evaluate the preventive effect of OVA encapsulated in PLG particles on airway inflammation, mice were intravenously administered OVA-PLG on day -7. On day 0, mice received intraperitoneal injections of OVA/Alum at a dose of 10 μg/mouse. On day 7, mice were again injected intravenously with OVA-PLG, and on day 14 they were given another extraperitoneal injection of 10 μg/mouse OVA/Alum. Between days 28 and 30, mice were injected with aerosolized OVA three times.

As shown in FIG. 19, prophylactic administration of OVA-PLG decreased the secretion of IL-4, IL-5, IL-13, and IL-10 and decreased the levels of serum OVA IgE and eosinophils in the lung.

OVA peptide encapsulated in PLG particles, when administered prophylactically, inhibits the OVA-specific secondary immune response in vitro in mediastinal lymph nodes. As shown in FIG. 20A, proliferation in lymph nodes observed after repeated stimulation with 25 μg OVA is reduced in animals treated with OVA-PLG. Moreover, administration of OVA-PLG reduces cytokine release after repeated OVA stimulation. In FIG. 20B shows that the levels of IL-4, IL-5, IL-13 and IL-10 are reduced in mice treated with OVA-PLG.

Example 13

OVA peptide encapsulated in PLG particles, when administered therapeutically, inhibits allergic airway inflammation and OVA-specific Th2 responses in vivo

To evaluate the therapeutic effect of OVA encapsulated in PLG particles on airway inflammation, mice were intraperitoneally administered OVA/Alum at a dose of 10 μg/mouse on days 0 and 14. Mice were intravenously administered OVA-PLG on days 28 and 42. Between days 56 and 58, mice were injected with aerosolized OVA three times.

As shown in FIG. 21, therapeutic administration of OVA-PLG decreased the secretion of IL-4, IL-5, IL-13, and IL-10 and decreased the levels of serum OVA IgE and eosinophils in the lung.

In FIG. 22 shows that OVA peptide encapsulated in PLG particles, when administered therapeutically, reduces the level of OVA-specific Th2 cytokines in the BAL better than OVA-bound PLG particles. Animals were treated as described above, except that on days 28 and 42, mice were administered either OVA encapsulated in PLG particles or OVA bound to PLG particles. Surprisingly, it was found that the encapsulated OVA peptide inhibited the secretion of Th2 cytokines more than the OVA peptide bound to the surface of the PLG particle.

Example 14

Tolerance induced by PLG particles with p31 chromogranin A peptide inhibits type I diabetes

Type I diabetes was induced in BDC2.5 mice by isolating cells from the spleen, axillary, brachial, inguinal and pancreatic lymph nodes of 3-week-old mice. Isolated cells were cultured and activated in vitro by incubating 2 x 10 ⁶ cells/ml with 0.5 μM p31 peptide for 96 hours. 5 x 10 ⁶ cells were transfected by intravenous injection into NOD.SCID mice (6-8 weeks) at time point 0. Tolerance in mice was induced by intravenous injection of p31 or MOG _35-55 peptide coupled to SP or PLG after a period of time from 2 hours to 3 days.

In FIG. 23A and 23B show the blood glucose levels of the animals after treatment. Administration of p31 peptide-linked PLG particles resulted in lower blood glucose levels compared with levels observed with MOG peptide-linked particles _35-55 . In FIG. 23C shows that the percentage of cells secreting IFNγ observed in animals was also reduced in mice treated with p31-PLG compared to mice treated with MOG _35-55 -PLG particles.

Treg cells are required for p31-PLG-induced tolerance. Type I diabetes was induced in mice as described above, and 2 hours after transfer of activated cells to NOD.SCID mice, mice were tolerized with either p31-PLG particles or MOG _35-55 -PLG particles. As shown in FIG. 24, reduction in Treg cell numbers impaired tolerance induced by p31-PLG particle administration.

Example 15

Tolerance Induced by Insulin-Bound PLG Particles Inhibits the Development of Spontaneous Type I Diabetes in NOD Mice

NOD mice were intravenously administered PLG particles bound to either BSA (N = 22) or insulin (N = 23) at 6, 8, and 10 weeks of age. The mice were then assessed for the development of diabetes, which was defined as a blood glucose level >250 mg/dL. As shown in FIG. 25, administration of insulin-linked PLG particles significantly increased the proportion of mice that did not develop diabetes for more than 300 days (69.6% versus 22.7%; p = 0.0027).

Example 16

Engraftment kinetics

Tolerance was induced in female CD45.2 mice using either OVA-PLG or the control peptide Dby-PLG (the major HY antigen expressed in male C57BL/6 mice) on day -7. On day 1, mice received a radiation dose of 200 rad and were then transplanted with 1 x ¹⁰⁶ , 5 x ¹⁰⁶ , or 1 x ¹⁰⁷ bone marrow cells from male CD45.1 mice on day 0. Tolerance was induced in recipient mice using OVA-PLG, Dby-SP, or Dby-PLG on day 1, and blood was collected for chimerism analysis by FACS. In FIG. Figure 26 shows the percentage of donor CD45.1 cells observed in the recipient mouse.

In FIG. Figure 27 shows the percentage of donor CD45.1 cells in recipient mice after tolerance induction with OVA-PLG, Dby-SP or Dby-PLG on day 1. No significant engraftment was observed in one mouse from the positive control group (~10%). No engrafted donor cells were observed in any of the negative control mice. No significant engraftment was observed in one mouse in the Dby-SP group (~10%). Two OVA-PLG mice engrafted donor cells (~10%): one experienced complete rejection by 16 weeks. In one Dby-PLG mouse, rejection began at week 12 and reached 10% by week 16. In the Dby-PLG group, engraftment ranged from 10-56% at 16 weeks. In OVA-PLG mice, 1) spontaneous engraftment was observed, 2) sequence homology between OVA323 and Dby, or 3) tolerogenic properties of the particles. Dby-PLG particles provided greater engraftment than Dby-SP and OVA-PLG.

In FIG. 28 shows that the timing of tolerance induction affects the percentage of CD45.1 cells in the recipient mouse. In the positive control group, less engraftment was observed (~4%) than expected (~10%). One mouse from the negative control group had 5% engraftment. Of all 3 OVA-PLG groups, engraftment was demonstrated by one mouse in the -7th day, +1st day group (12%). Tolerance on day 1 is of greater clinical significance than tolerance on day 7.

Example 17

Coumarin-6-stained PLGA particles are not trackable 24 hours after administration

Mice were injected with coumarin-6-stained PLGA particles that had or did not have associated antigen. As shown in FIG. 29, particles were monitored 3 hours after administration, but not 24 hours after administration. Sections of the spleen (left column), liver (middle column) and lung (right column) from intact mice without injections (top row) and from mice intravenously treated with fluorescent PLGA/PEMA microparticles, taken 3 hours after injection (middle row) and 24 hours after injection (bottom row), counterstained with DAPI.

Example 18

Nanoparticles associate in vivo with macrophages

Analysis of the liver at 6 hours and 15 hours after administration shows that PLGA particles colocalize with F4/80 ⁺ cells in the liver (Figure 30).

Marginal zone macrophages preferentially engulf TAMRA-labeled particles associated with PLP _139-151 24 hours after intravenous infusion. As shown in FIG. 31, the largest percentage of PLP _139-151 ⁺ cells are marginal zone macrophages.

Example 19

Inhibition of R-EAE in SJL/J mice using surface-functionalized lactide-glycolide copolymer particles containing soluble PLP139-151 in their cores

Groups of SJL/J mice were injected intravenously with 2.5 mg of surface-functionalized lactide-glycolide copolymer particles 500-700 nm in size containing the soluble peptide PLP139-151 in the cores on day -7 and day 1 relative to priming with PLP139- 151/CFA on day 0. Control mice were primed on day 0, but did not receive particles on day 7 or day -1. Mice were monitored for clinical signs of R-EAE for an additional 20 days.

The results presented in Fig. 32 show the dependence of the daily average clinical assessment score on the number of days after PLP139-151/CFA priming. R-EAE induced by PLP139-151/CFA is inhibited in SJL/J mice by inducing immunological tolerance using surface-functionalized lactide-glycolide copolymer particles containing soluble PLP139-151 in their core.

Example 20

Inhibition of allergic airway inflammation using surface-functionalized lactide-glycolide copolymer particles containing soluble ovalbumin

Allergic airway inflammation (AIA) was induced in mice. Groups of Balb/c mice were injected intravenously with 2.5 mg of surface-functionalized lactide-glycolide copolymer particles measuring 500-700 nm, containing soluble ovalbumin or soluble bovine serum albumin (control) in the cores, on days -7 and +7 day relative to priming with ovalbumin/alum on day 0 and day +14. Mice were irritated with aerosol ovalbumin on days +28-30. Mice were then euthanized and bronchoalveolar lavage fluid was collected. Serum ovalbumin-specific IgE levels were also measured.

The number of eosinophils in bronchoalveolar lavage indicates the severity of AAI—the higher the number, the more severe the disease. Serum IgE levels indicate the severity of AAI—the higher the levels, the more severe the disease.

In FIG. 33 showed that mice treated with encapsulated OVA-PLG showed the greatest reduction in eosinophil accumulation. In FIG. 34 shows that mice treated with encapsulated OVA-PLG exhibited the greatest reduction in serum IgE levels compared to untreated or treated control animals.

Ovalbumin/alum combination-induced allergic airway inflammation in Balb/c mice was inhibited by inducing immunological tolerance using surface-functionalized lactide-glycolide copolymer particles containing soluble ovalbumin in their cores.

Example 21

Synthesis of surface-functionalized lactide-glycolide copolymer particles with encapsulated antigen

This example details the composition and partially characterizes biodegradable lactide-glycolide copolymer particles that have been surface-functionalized with a high density of carboxyl groups and which contain a soluble antigen in their cores, the cores being surrounded by a lactide-glycolide copolymer shell, and the particles are used for tolerance induction in autoimmune diseases and for the treatment of allergies.

The high density of carboxyl groups was achieved by using poly(ethylene alt-maleic anhydride) (PEMA), a polymer with carboxyl groups embedded in the backbone, as a surfactant for the emulsification process.

As described above, biodegradable lactide-glycolide copolymer particles containing soluble PLP139-151 in their cores and surface functionalized with a high density of carboxyl groups effectively induce immunological tolerance in SJL/J mice with PLP139-151/CFA-induced murine R-EAE. models of multiple sclerosis. In addition, biodegradable lactide-glycolide copolymer particles containing soluble ovalbumin in their cores and surface-functionalized with a high density of carboxyl groups effectively induce immunological tolerance in Balb/c mice with ovalbumin/Alum-induced AAI, a mouse model of allergic asthma.

Particles of a lactide-glycolide copolymer containing soluble ovalbumin or bovine serum albumin in their cores, surface-functionalized with a high density of carboxyl groups, were synthesized by the “double emulsion - solvent evaporation” method as follows.

1. 150 µl of a solution of 200 mg/ml ovalbumin or bovine serum albumin in endotoxin-free water was added dropwise to 2 ml of 20% w/v. a solution of a copolymer of lactide and glycolide in dichloromethane in a 20 ml scintillation vial.

2. The resulting mixture was placed on ice and treated with ultrasound for 30 seconds at a power of 10 W using a sonicator with a probe.

3. Add 10 ml of 1% w/v. a solution of poly(ethylene-alt-maleic anhydride) in water.

4. The resulting mixture was placed on ice and sonicated for 30 seconds at a power of 16 W using a sonicator with a probe.

5. The resulting emulsion was poured into 200 ml of 0.5% w/v. solution of poly(ethylene alt-maleic anhydride) in a 600 ml beaker and stirred overnight to solidify the particles.

6. The solidified particles were purified by centrifugation and washed 3 times with bicarbonate buffer pH 9.6.

7. The purified particles were resuspended in a solution containing 4% w/v. sucrose and 3% w/v. D-mannitol in water, quickly frozen in liquid nitrogen and lyophilized to dryness.

In FIG. 35 shows the characterization of surface-functionalized particles containing soluble PLP139-151, a lactide-glycolide copolymer, in their cores by dynamic light scattering analysis. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 1.792 x 105 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a Z-average diameter of 584 nm, a maximum diameter of 679 nm, and a polydispersity coefficient of 0.162. These results are typical of 6 batches of particles synthesized according to the protocol described above.

In FIG. 36 shows the characterization of surface-functionalized lactide-glycolide copolymer particles containing soluble PLP139-151 in their cores by ζ-potential measurements. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 6.67 x 104 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a maximum ζ-potential of −48.9 mV and a ζ-deviation of 5.14 mV. These results are typical of 6 batches of particles synthesized according to the protocol described above.

In FIG. 37 shows the characterization of surface-functionalized particles containing soluble ovalbumin, a lactide-glycolide copolymer in their cores, by dynamic light scattering analysis. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 1.822 x 105 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a Z-average diameter of 569.7 nm, a maximum diameter of 700.3 nm, and a polydispersity coefficient of 0.230. These results are typical of 3 batches of particles synthesized according to the protocol described above.

In FIG. 38 shows the characterization of surface-functionalized lactide-glycolide copolymer particles containing soluble ovalbumin in their cores by ζ-potential measurement. Surface-functionalized lactide-glycolide copolymer particles were analyzed on a Malvern Zetasizer Nano ZS (Malvern Instruments, Westborough, Massachusetts) at a count rate of 2.67 x 104 counts per second in 18.2 MΩ water. The population of surface-functionalized lactide-glycolide copolymer particles had a maximum ζ-potential of −52.2 mV and a ζ-deviation of 5.38 mV. These results are typical of 3 batches of particles synthesized according to the protocol described above.

Example 22

Surface-functionalized liposomes containing soluble PLP _139-151 within their cores induce immunological tolerance in a mouse model of multiple sclerosis

The present inventors also discovered that biodegradable liposomal delivery vehicles, surface functionalized with a high density of negatively charged groups and containing soluble antigen in their cores, induce immunological tolerance in R-EAE, a murine model of multiple sclerosis.

The liposomes used in the study consisted of the following lipids in the following molar ratios - 30:30:40 phosphatidylcholine:phosphatidylglycerol:cholesterol. Groups of SJL/J mice were intravenously injected with 200 nm surface-functionalized liposomes (10 µmol total lipid per mouse) containing the soluble PLP _139-151 peptide in their cores on day -7 relative to PLP _139-151 /CFA priming on day 0 -th day. Control mice were primed on day 0, and on day 7 they were injected with surface-functionalized liposomes measuring 500-700 nm (10 µmol of total lipid per mouse), containing in their cores the soluble OVA _323-339 peptide. Mice were monitored for clinical signs of R-EAE for an additional 17 days.

The results show the dependence of the daily average clinical assessment score on the number of days after PLP _139-151 /CFA priming. As shown in FIG. 39, animals receiving surface-functionalized liposomes containing the soluble PLP peptide _139-151 in their cores had lower clinical scores than animals receiving surface-functionalized liposomes containing the soluble OVA _323-339 peptide.

The study results show that biodegradable liposomes containing PLP _139-151 in their cores and surface functionalized with a high density of negatively charged groups effectively induce immunological tolerance in SJL/J mice with R-EAE induced by PLP _139-151 /CFA mouse model multiple sclerosis.

Tolerance induced by antigen-bound or antigen-encapsulating particles is antigen-specific, dose-dependent, and long-term (>150 days). Tolerance is best induced by intravenous administration of an antigen-bound particle with a diameter of 500 nm to 1 μm with a zeta potential of < -5 mV. Induction of tolerance depends on the uptake of particles by the phagocytic receptor MARCO, which “sees” polyanionic surfaces (eg, carboxylated PS/PLG particles). Tolerance is induced and maintained through a combination of anergy (partially reversed by anti-PD-1 antibodies and agonistic anti-CD40 antibodies) and iTreg (partially addressed by anti-CD25 antibodies). The particles of the invention accumulate predominantly in the liver and macrophages of the marginal zone (CD11b ^hi CD11c ^lo MARCO ⁺ Sign-R1 ⁺ Siglec-1 ^- ).

There are many advantages of using antigen-associated particles to treat autoimmune diseases compared to using antigen-excited or antigen-targeted immature tolerogenic dendritic cells or engineered antigen-specific Treg cells. Rapid and easy tolerogen production and induction using a ready-made, universal tolerogenic carrier suitable for production in accordance with Good Manufacturing Practices (GMP); there is no need to isolate and expand immature dendritic cells or Treg cells ex vivo; no need to worry about immature dendritic cells being activated by ex vivo manipulation and becoming stimulatory rather than tolerogenic, or about Treg cells converting to Th1/17 after transfer; Because immature host marginal zone APCs process and present antigen in a tolerogenic manner, host APCs can select desired immunodominant autoepitopes from PLG particles encapsulating intact autoantigens or tissue extracts (e.g., OVA encapsulated in PLG particles prevents OVA/Alum-induced AAD) ; and the protocol is antigen-specific, without inhibition by an adventitious agent, safe, highly effective, and can induce immunological tolerance in both effector T cells (Th1, Th2, Th17 and CD8) and naïve T cells involved in epitope spreading.

Synthetic biodegradable particles and liposomes may provide ease of production, widespread availability of therapeutic agents, and an increase in the number of possible treatment sites. For this purpose, surface-functionalized biodegradable lactide-glycolide copolymer particles with a high density of surface carboxyl groups were specially developed using the surfactant poly(ethylene-alt-maleic anhydride).

Surface-functionalized liposomes have also been developed using phosphatidylcholine: phosphatidylglycerol: cholesterol in a ratio of 30: 30: 40.

Additionally, such particles have been developed to contain soluble ovalbumin in their cores to overcome problems associated with chemical contamination and purity that may arise during surface conjugation of a peptide or protein. These surface-functionalized lactide-glycolide copolymer particles containing soluble ovalbumin in their cores effectively prevent disease progression and consequently induce immunological tolerance in AAI induced in Balb/c mice by the ovalbumin/Alum combination, a mouse model of allergic asthma. The peptide or protein conjugated to carboxyl-functionalized lactide-glycolide copolymer particles using EDC attaches in a promiscuous manner, resulting in the formation of antigen aggregates and particle-antigen-particle aggregates that are difficult to characterize and purify to obtain homogeneous populations.

A homogeneous population of surface-functionalized lactide-glycolide copolymer particles containing soluble ovalbumin in their cores, which do not require surface conjugation with the antigen, was obtained.

Additionally, biodegradable liposomes containing PLP _139-151 in their cores and surface functionalized with a high density of negatively charged groups were shown to effectively induce immunological tolerance in SJL/J mice with R-EAE induced by PLP _139-151 /CFA, a murine model of MS. sclerosis.

The liposomes and lactide-glycolide copolymer particles of the present invention have many advantages. The benefits are as follows.

1) Biodegradable particles do not remain in the body for a long time, and the time for complete decomposition can be controlled.

2) Particles and liposomes can be functionalized to facilitate internalization without cellular activation. For this purpose, phosphatidylserine was introduced into PLG microspheres.

3) Particles and liposomes can also be designed to include ligands that target a specific cell population.

4) Anti-inflammatory cytokines such as IL-10 and TGF-β can also be included to limit the activation of the cell type internalizing the particles and to facilitate the induction of tolerance through anergy and/or killing, as well as the activation of regulatory T cells.

This combined function of a particle or liposome can provide a multifaceted approach to tolerance induction, such that the particle configuration is a significant advance over polystyrene particles. Potential clinical applications of this tolerance induction technology include:

(1) autoimmune diseases mediated by T cells and antibodies (such as multiple sclerosis, type I diabetes, rheumatoid arthritis, systemic lupus, etc.) - tolerance can be induced by particles in complex with significant autoantigens underlying a particular autoimmune diseases;

(2) food and pulmonary allergies, skin allergies and asthma - tolerance can be induced by particles in combination with specific food (e.g. peanut proteins, etc.), injected (bee venom proteins, etc.) or inhaled substances (e.g. , ragweed pollen proteins, proteins contained in the skin cells of pets, etc.), which cause an allergic reaction;

(3) graft rejection—tolerance to graft antigens can be induced on donor organs or cells before transplantation to prevent graft rejection by the recipient;

(4) enzyme replacement therapy - tolerance to enzymes that are not produced in patients with a genetic deficiency can be induced to prevent the formation of neutralizing antibodies to recombinant enzymes administered to treat the specific deficiency.

Example 23

Particles most effective in inducing tolerance have a negative charge and an average diameter of 500 nm

The main parameters of the particle from the point of view of tolerance induction are the size and charge of the composition. As shown in FIG. 40A and B, particle charge affects the efficiency of tolerance induction. A comparison of EAE mice treated with OVA-conjugated -25 mV or -60 mV particles showed that formulations containing -60 mV particles induce tolerance more effectively than -25 mV particles. Mice were injected with TIMPs (tolerogenic immunomodifying particles) with a charge of -60 mV or -25 mV. Mice were injected with OVA _323-339 -TIMP _-60mv , OVA _323-339 -PLGA _-25mv , PLP _139-151 -TIMP _-60mv or PLP _139-151 -PLGA _-25mv (all antigens are encapsulated) and a clinical score was determined. Panel (A) shows the mean clinical assessment score and panel (B) shows the mean total score in animals with EAE.

The negative charge of a particle affects the ability of the particle to interact with the phagocytic receptor MARCO. In FIG. 41 shows that the charge of the immunomodifying particle is important for directing the immunomodifying particle to the antigen presenting cell. Wild-type or MARCO −/+ animals were treated with either PS-IMP or vehicle. The results indicate that particles with reduced negative charge have lower efficiency due to less interaction with phagocytic receptors such as MARCO, which have positively charged collagen-like domains.

In addition to charge, tolerance induction is influenced by the size and composition of biodegradable TIMPs. As shown in FIG. 42A, the most effective for inducing tolerance in the EAE model were particles with an average diameter of about 500 nm. Mice were injected with 500 nm OVA _323-339 -PSB particles, 100 nm PLP _139-151 -PSB particles, 500 nm PLP _139-151 -PSB particles, 1.75 μm PLP _139-151 -PSB particles, or 4.5 μm PLP particles _139-151 -PSB and determined the clinical score of the disease. The PLGA carriers had slow release kinetics over 1 month, and changing the polymer ratio may affect particle release. Rapid particle uptake and rapid clearance/degradation are required for tolerance induction. Since a lactide:glycolide ratio greater than 50:50 reduces the rate of degradation, the particles of the invention in one embodiment have a lactide:glycolide ratio of 50:50. In FIG. 42B shows that the particles break down quickly.

In addition to the charge and average diameter of TIMPs, encapsulating antigens within the particle is more effective in an allergy model than binding the particles to the antigen. In the allergy model, antigen-bound particles had a predisposition to induce an anaphylactic reaction and were not an effective therapy. On the contrary, as shown in FIG. 43, 60 mV TIMPs are therapeutically effective in a mouse model of allergy. Animals were exposed to OVA as the allergen and then exposed to empty PLG or TIMP particles, PLG or TIMP particles with OVA, or nothing. Panel (A) shows that OVA-PLG particles do not reduce the TH2 response in allergy. Panel (B) shows that TIMP _PEMA-60mB inhibits the TH2 response. Panel (C) shows that _PEMA-60mB TIMPs inhibit secondary immune responses.

Example 24

Single-emulsion synthesis of surface-functionalized lactide-glycolide copolymer particles with encapsulated antigen

Polypeptide antigens can be incorporated into lactide-glycolide copolymer particles using a double emulsion process (see Example 21), however, the present inventors have found that when incorporating more hydrophobic particles such as gliadin, it is better to incorporate the antigen into the particle using a single emulsion process using solvents.

To create particles containing gliadin, we used a copolymer of lactide and glycolide with carboxyl end groups, a D,L-lactide : glycolide ratio of 50 : 50 and a specific viscosity of 0.18 dl/g in hexafluoro-2-propanol. Particles of a lactide-glycolide copolymer containing gliadin in their cores, surface-functionalized with a high density of carboxyl groups, were synthesized by the “single emulsion - solvent evaporation” method as follows.

1. Five milligrams of gliadin and 200 mg of PLG were dissolved in 50 μl of trifluoroacetic acid (TFA) and 700 μl of dimethyl sulfoxide and 1250 μl of dichloromethane (DCM).

2. The resulting mixture was added dropwise to 4 ml of 1% w/v. aqueous PEMA solution and sonicated for 30 s at 100% amplitude.

3. The resulting emulsion was poured into 200 ml of 0.5% w/v. aqueous PEMA solution and stirred for 12 hours to completely evaporate the DCM.

4. The particles were then washed three times in 0.1 M sodium carbonate/sodium bicarbonate buffer, pH 9.6. Alternatively, double distilled _H2O can be used to wash the particles.

5. The purified particles were resuspended in a solution containing 4% w/v. sucrose and 3% w/v. D-mannitol in water, quickly frozen to -80 °C and lyophilized to dryness.

Although specific embodiments of the invention are described and illustrated herein, such embodiments are to be considered only as illustrative of the invention and not as limiting of the invention as defined in the appended claims.

All patents, applications and other publications cited herein are incorporated by reference in their entirety.

--->

LIST OF SEQUENCES

<110> Cour Pharmaceuticals

<120> Peptide conjugated particles

<130> COUR-002/01US

<160> 5140

<170> PatentIn, version 3.5

<210> 1

<211> 21

<212>PRT

<213> Mus musculus

<400> 1

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu

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Tyr Arg Asn Gly Lys

20

<210> 2

<211> 9

<212>PRT

<213> Homo sapiens

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Ala Ser Phe Asp Lys Ala Lys Leu Lys

15

<210> 3

<211> 14

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<213> Oryctolagus cuniculus

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Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr

1 5 10

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<211> 20

<212>PRT

<213> Homo sapiens

<400> 4

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala

1 5 10 15

Thr Ala Ser Thr

20

<210> 5

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5

Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe Cys Gly Cys Gly

1 5 10 15

His Glu Ala Leu

20

<210> 6

<211> 20

<212>PRT

<213> Homo sapiens

<400> 6

Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser

1 5 10 15

Ile Ala Phe Pro

20

<210> 7

<211> 9

<212>PRT

<213> Human herpes virus

<400> 7

Cys Leu Gly Gly Leu Leu Thr Met Val

15

<210> 8

<211> 9

<212>PRT

<213> Human herpes virus

<400> 8

Cys Arg Val Leu Cys Cys Tyr Val Leu

15

<210> 9

<211> 9

<212>PRT

<213> Homo sapiens

<400> 9

Asp Ala Lys Ile Arg Ile Phe Asp Leu

15

<210> 10

<211> 18

<212>PRT

<213> Homo sapiens

<400> 10

Asp Thr Pro Tyr Leu Asp Ile Thr Tyr His Phe Val Met Gln Arg Leu

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ProLeu

<210> 11

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 11

Glu Asn Pro Val Val Ala Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 12

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 12

Glu Asn Pro Val Val Asp Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 13

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 13

Glu Asn Pro Val Val His Phe Phe Ala Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 14

<211> 17

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 14

Glu Asn Pro Val Val His Phe Phe Ala Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro

<210> 15

<211> 15

<212>PRT

<213> Homo sapiens

<400> 15

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 16

<211> 17

<212>PRT

<213> Homo sapiens

<400> 16

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro

<210> 17

<211> 20

<212>PRT

<213> Homo sapiens

<400> 17

Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr

1 5 10 15

Val Thr Gly Gly

20

<210> 18

<211> 9

<212>PRT

<213> Homo sapiens

<400> 18

Phe Leu Tyr Gly Ala Leu Leu Leu Ala

15

<210> 19

<211> 21

<212>PRT

<213> Homo sapiens

<400> 19

Phe Tyr Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys

1 5 10 15

Thr Thr Ile Cys Gly

20

<210> 20

<211> 24

<212>PRT

<213> Human herpes virus

<400> 20

Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Gly Gly Arg Pro Gly Ala Pro Gly

20

<210> 21

<211> 9

<212>PRT

<213> Human herpes virus

<400> 21

Gly Leu Cys Thr Leu Val Ala Met Leu

15

<210> 22

<211> 13

<212>PRT

<213> Mus musculus

<400> 22

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe

1 5 10

<210> 23

<211> 18

<212>PRT

<213> Mus musculus

<400> 23

Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala

1 5 10 15

Arg Arg

<210> 24

<211> 15

<212>PRT

<213> Homo sapiens

<400> 24

Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys

1 5 10 15

<210> 25

<211> 13

<212>PRT

<213> Homo sapiens

<400> 25

Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys

1 5 10

<210> 26

<211> 20

<212>PRT

<213> Homo sapiens

<400> 26

Lys Gly Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Tyr

1 5 10 15

Arg Gly Gln His

20

<210> 27

<211> 14

<212>PRT

<213> Homo sapiens

<400> 27

Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser

1 5 10

<210> 28

<211> 20

<212>PRT

<213> Homo sapiens

<400> 28

Leu Phe Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu

1 5 10 15

Ile Glu Thr Tyr

20

<210> 29

<211> 10

<212>PRT

<213> Human herpes virus

<400> 29

Leu Leu Asp Phe Val Arg Phe Met Gly Val

1 5 10

<210> 30

<211> 9

<212>PRT

<213> Human herpes virus

<400> 30

Leu Leu Trp Thr Leu Val Val Leu Leu

15

<210> 31

<211> 20

<212>PRT

<213> Homo sapiens

<400> 31

Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe

1 5 10 15

Phe Gly Gly Asp

20

<210> 32

<211> 20

<212>PRT

<213> Homo sapiens

<400> 32

Leu Val Gly Ala Pro Phe Ala Ser Leu Val Ala Thr Gly Leu Cys Phe

1 5 10 15

Phe Gly Val Ala

20

<210> 33

<211> 20

<212>PRT

<213> Homo sapiens

<400> 33

Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala

1 5 10 15

Val Arg Gln Ile

20

<210> 34

<211> 19

<212>PRT

<213> Homo sapiens

<400> 34

Met Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Phe

1 5 10 15

Thr Lys Phe

<210> 35

<211> 13

<212>PRT

<213> Human herpes virus

<400> 35

Met Asp Arg Pro Arg Thr Pro Pro Pro Ser Tyr Ser Glu

1 5 10

<210> 36

<211> 9

<212>PRT

<213> Human herpes virus

<400> 36

Asn Leu Val Pro Met Val Ala Thr Val

15

<210> 37

<211> 20

<212>PRT

<213> Mus musculus

<400> 37

Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro

1 5 10 15

Pro Pro Ser Gln

20

<210> 38

<211> 14

<212>PRT

<213> Mus musculus

<400> 38

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys

1 5 10

<210> 39

<211> 20

<212>PRT

<213> Homo sapiens

<400> 39

Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser Leu Glu

1 5 10 15

Arg Val Cys His

20

<210> 40

<211> 8

<212>PRT

<213> Human herpes virus

<400> 40

Arg Ala Lys Phe Lys Gln Leu Leu

15

<210> 41

<211> 9

<212>PRT

<213> Human herpes virus

<400> 41

Arg Pro Pro Ile Phe Ile Arg Arg Leu

15

<210> 42

<211> 20

<212>PRT

<213> Homo sapiens

<400> 42

Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met

1 5 10 15

Tyr Gly Val Leu

20

<210> 43

<211> 9

<212>PRT

<213> Homo sapiens

<400> 43

Ser Leu Ser Arg Phe Ser Trp Gly Ala

15

<210> 44

<211> 9

<212>PRT

<213> Human herpes virus

<400> 44

Ser Val Arg Asp Arg Leu Ala Arg Leu

15

<210> 45

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 45

Ser Val Ser Val Gly Met Lys Pro Ser Pro Arg Pro

1 5 10

<210> 46

<211> 15

<212>PRT

<213> Human herpes virus

<400> 46

Thr Gly Gly Val Tyr His Phe Val Lys Lys His Val His Glu Ser

1 5 10 15

<210> 47

<211> 20

<212>PRT

<213> Homo sapiens

<400> 47

Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln

1 5 10 15

Asp Tyr Glu Tyr

20

<210> 48

<211> 10

<212>PRT

<213> Human herpes virus

<400> 48

Thr Pro Arg Val Thr Gly Gly Gly Ala Met

1 5 10

<210> 49

<211> 20

<212>PRT

<213> Homo sapiens

<400> 49

Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg

1 5 10 15

Asp Ser Arg Ser

20

<210> 50

<211> 13

<212>PRT

<213> Cavia porcellus

<400> 50

Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro

1 5 10

<210> 51

<211> 9

<212>PRT

<213> Homo sapiens

<400> 51

Val Met Ala Pro Arg Thr Leu Val Leu

15

<210> 52

<211> 20

<212>PRT

<213> Mus musculus

<400> 52

Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu

1 5 10 15

Ser Leu Ser Arg

20

<210> 53

<211> 9

<212>PRT

<213> Homo sapiens

<400> 53

Val Val His Phe Phe Lys Asn Ile Val

15

<210> 54

<211> 20

<212>PRT

<213> Homo sapiens

<400> 54

Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser

1 5 10 15

Ile Gly Ser Leu

20

<210> 55

<211> 23

<212>PRT

<213> Human T-cell lymphotropic virus

<400> 55

Ile Gln Ala Ile Val Ser Ser Pro Cys His Asn Ser Leu Ile Leu Pro

1 5 10 15

Pro Phe Ser Leu Ser Pro Val

20

<210> 56

<211> 24

<212>PRT

<213> Human T-cell lymphotropic virus

<400> 56

Leu Pro Pro Thr Ala Pro Pro Leu Leu Pro His Ser Asn Leu Asp His

1 5 10 15

Ile Leu Glu Pro Ser Ile Pro Trp

20

<210> 57

<211> 20

<212>PRT

<213> Human T-cell lymphotropic virus

<400> 57

Pro Pro Pro Tyr Val Glu Pro Thr Ala Pro Gln Val Leu Pro Val Met

1 5 10 15

His Pro His Gly

20

<210> 58

<211> 23

<212>PRT

<213> Human T-cell lymphotropic virus

<400> 58

Gln Gly Gly Leu Cys Lys Ala Leu Gln Glu Gln Cys Arg Phe Pro Asn

1 5 10 15

Ile Thr Asn Ser His Val Pro

20

<210> 59

<211> 20

<212>PRT

<213> Human T-cell lymphotropic virus

<400> 59

Arg Ala Ser Leu Ser Thr Trp His Val Leu Tyr Ser Pro Asn Val Ser

1 5 10 15

Val Pro Ser Ser

20

<210> 60

<211> 10

<212>PRT

<213> Homo sapiens

<400> 60

Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10

<210> 61

<211> 9

<212>PRT

<213> Homo sapiens

<400> 61

Phe Lys Asn Ile Val Thr Pro Arg Thr

15

<210> 62

<211> 11

<212>PRT

<213> Cavia porcellus

<400> 62

His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10

<210> 63

<211> 15

<212>PRT

<213> Homo sapiens

<400> 63

Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile

1 5 10 15

<210> 64

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 64

Val His Phe Phe Lys Asn Ile Val Thr Ala Arg Thr Pro

1 5 10

<210> 65

<211> 13

<212>PRT

<213> Homo sapiens

<400> 65

Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10

<210> 66

<211> 9

<212>PRT

<213> Human herpes virus

<400> 66

Ser Gln Ala Pro Leu Pro Cys Val Leu

15

<210> 67

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 67

His Thr Gln Pro Tyr Ala Tyr Glu Ala Arg Asp His

1 5 10

<210> 68

<211> 15

<212>PRT

<213> Bos taurus

<400> 68

Phe Lys Ala Asp Glu Lys Lys Phe Trp Gly Lys Tyr Leu Tyr Glu

1 5 10 15

<210> 69

<211> 16

<212>PRT

<213> Homo sapiens

<400> 69

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile

1 5 10 15

<210> 70

<211> 14

<212>PRT

<213> Mus musculus

<400> 70

Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr

1 5 10

<210> 71

<211> 17

<212>PRT

<213> Homo sapiens

<400> 71

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro

1 5 10 15

Arg

<210> 72

<211> 22

<212>PRT

<213> Mus musculus

<400> 72

Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu

1 5 10 15

Tyr Leu Ile Asn Val Ile

20

<210> 73

<211> 9

<212>PRT

<213> Mus musculus

<400> 73

Ala Ser Gln Lys Arg Pro Ser Gln Arg

15

<210> 74

<211> 15

<212>PRT

<213> Homo sapiens

<400> 74

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

<210> 75

<211> 19

<212>PRT

<213> Homo sapiens

<400> 75

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

Thr Pro Pro

<210> 76

<211> 26

<212>PRT

<213> Homo sapiens

<400> 76

Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu

1 5 10 15

Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro

20 25

<210> 77

<211> 18

<212>PRT

<213> Homo sapiens

<400> 77

Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp

1 5 10 15

Tyr Glu

<210> 78

<211> 16

<212>PRT

<213> Homo sapiens

<400> 78

Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu

1 5 10 15

<210> 79

<211> 25

<212>PRT

<213> Homo sapiens

<400> 79

Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser

1 5 10 15

Arg Ser Gly Ser Pro Met Ala Arg Arg

20 25

<210> 80

<211> 25

<212>PRT

<213> Homo sapiens

<400> 80

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Leu Lys Gly Val Asp Ala

1 5 10 15

Gln Gly Thr Leu Ser Lys Ile Phe Lys

20 25

<210> 81

<211> 31

<212>PRT

<213> Homo sapiens

<400> 81

Glu Val Gly Glu Leu Ser Arg Gly Lys Leu Tyr Ser Leu Gly Asn Gly

1 5 10 15

Arg Trp Met Leu Thr Leu Ala Lys Asn Met Glu Val Arg Ala Ile

20 25 30

<210> 82

<211> 18

<212>PRT

<213> Homo sapiens

<400> 82

Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys

1 5 10 15

Thr Thr

<210> 83

<211> 33

<212>PRT

<213> Homo sapiens

<400> 83

Gly Asn Gly Arg Trp Met Leu Thr Leu Ala Lys Asn Met Glu Val Arg

1 5 10 15

Ala Ile Phe Thr Gly Tyr Tyr Gly Lys Gly Lys Pro Val Pro Thr Gln

20 25 30

Gly

<210> 84

<211> 20

<212>PRT

<213> Homo sapiens

<400> 84

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val

1 5 10 15

Gly Asp Glu Val

20

<210> 85

<211> 20

<212>PRT

<213> Homo sapiens

<400> 85

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser

1 5 10 15

His Gly Arg Thr

20

<210> 86

<211> 20

<212>PRT

<213> Homo sapiens

<400> 86

Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly

1 5 10 15

Arg Gly Leu Ser

20

<210> 87

<211> 20

<212>PRT

<213> Homo sapiens

<400> 87

Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe

1 5 10 15

Leu Pro Arg His

20

<210> 88

<211> 19

<212>PRT

<213> Homo sapiens

<400> 88

Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly

1 5 10 15

Tyr Gly Gly

<210> 89

<211> 21

<212>PRT

<213> Homo sapiens

<400> 89

Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu

1 5 10 15

Tyr Arg Asn Gly Lys

20

<210> 90

<211> 20

<212>PRT

<213> Homo sapiens

<400> 90

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser

1 5 10 15

Ala Ser Ile Gly

20

<210> 91

<211> 20

<212>PRT

<213> Homo sapiens

<400> 91

Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile

1 5 10 15

Ser Pro Gly Lys

20

<210> 92

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 92

Gln Lys Ser Gln Arg Ser Gln Ala Glu Asn Pro Val

1 5 10

<210> 93

<211> 12

<212>PRT

<213> Cavia porcellus

<400> 93

Gln Lys Ser Gln Arg Ser Gln Asp Glu Asn Pro Val

1 5 10

<210> 94

<211> 20

<212>PRT

<213> Homo sapiens

<400> 94

Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser

1 5 10 15

Ala His Lys Gly

20

<210> 95

<211> 20

<212>PRT

<213> Homo sapiens

<400> 95

Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly

1 5 10 15

Gly Asp Arg Gly

20

<210> 96

<211> 20

<212>PRT

<213> Homo sapiens

<400> 96

Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro

1 5 10 15

Met Ala Arg Arg

20

<210> 97

<211> 21

<212>PRT

<213> Homo sapiens

<400> 97

Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met

1 5 10 15

Tyr Gly Val Leu Pro

20

<210> 98

<211> 21

<212>PRT

<213> Homo sapiens

<400> 98

Thr Gly Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln

1 5 10 15

Asp Tyr Glu Tyr Leu

20

<210> 99

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 99

Val His Phe Phe Arg Asn Ile Val Thr Ala Arg Thr Pro

1 5 10

<210> 100

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 100

Val His Phe Phe Arg Asn Ile Val Thr Ala Arg Thr Pro

1 5 10

<210> 101

<211> 20

<212>PRT

<213> Homo sapiens

<400> 101

Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro

1 5 10 15

Ser Gln Gly Lys

20

<210> 102

<211> 21

<212>PRT

<213> Homo sapiens

<400> 102

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala

1 5 10 15

Thr Ala Ser Thr Met

20

<210> 103

<211> 44

<212>PRT

<213> Homo sapiens

<400> 103

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala

1 5 10 15

Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg His

20 25 30

Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe

35 40

<210> 104

<211> 21

<212>PRT

<213> Homo sapiens

<400> 104

Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg His Arg

1 5 10 15

Asp Thr Gly Ile Leu

20

<210> 105

<211> 23

<212>PRT

<213> Homo sapiens

<400> 105

Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys

1 5 10 15

Gly Leu Ser Ala Thr Val Thr

20

<210> 106

<211> 19

<212>PRT

<213> Homo sapiens

<400> 106

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro Pro Pro

<210> 107

<211> 18

<212>PRT

<213> Homo sapiens

<400> 107

Gly Phe Tyr Thr Thr Gly Ala Tyr Arg Gln Ile Phe Gly Asp Tyr Leu

1 5 10 15

Thr Thr

<210> 108

<211> 20

<212>PRT

<213> Homo sapiens

<400> 108

Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val

1 5 10 15

Asp Ala Gln Gly

20

<210> 109

<211> 25

<212>PRT

<213> Homo sapiens

<400> 109

Gly Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn

1 5 10 15

Leu Leu Ser Ile Cys Lys Thr Ala Glu

20 25

<210> 110

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 110

His Leu Ile Leu Ala Pro Ser Ile Arg His Ala Pro

1 5 10

<210> 111

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 111

His Leu Val Met Ala Pro Ser Val Ala Arg Gly Leu

1 5 10

<210> 112

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 112

His Val Gln Leu Ala Pro Pro Ile Ala Leu Arg His

1 5 10

<210> 113

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 113

His Val Val Leu Ala Pro Asn Val Gln Ser Pro Leu

1 5 10

<210> 114

<211> 24

<212>PRT

<213> Homo sapiens

<400> 114

His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu

1 5 10 15

Asn Pro Val Val His Phe Phe Lys

20

<210> 115

<211> 14

<212>PRT

<213> Homo sapiens

<400> 115

Lys Lys Gln Ser Lys Pro Val Thr Thr Pro Glu Glu Ile Ala

1 5 10

<210> 116

<211> 33

<212>PRT

<213> Homo sapiens

<400> 116

Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr

1 5 10 15

Leu Ile Asn Val Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala

20 25 30

Ser

<210> 117

<211> 30

<212>PRT

<213> Homo sapiens

<400> 117

Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro

1 5 10 15

Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe

20 25 30

<210> 118

<211> 23

<212>PRT

<213> Homo sapiens

<400> 118

Leu Thr Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu

1 5 10 15

Met Gly Arg Gly Thr Lys Phe

20

<210> 119

<211> 20

<212>PRT

<213> Bos taurus

<400> 119

Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg

1 5 10 15

Gly Thr Lys Phe

20

<210> 120

<211> 21

<212>PRT

<213> Homo sapiens

<400> 120

Arg His Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala

1 5 10 15

Arg His Gly Phe Leu

20

<210> 121

<211> 22

<212>PRT

<213> Homo sapiens

<400> 121

Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys

1 5 10 15

Ala Asp Ala Arg Met Tyr

20

<210> 122

<211> 34

<212>PRT

<213> Homo sapiens

<400> 122

Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His

1 5 10 15

Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly His Pro

20 25 30

Asp Lys

<210> 123

<211> 20

<212>PRT

<213> Bos taurus

<400> 123

Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly Gly Gln

1 5 10 15

Lys Gly Arg Gly

20

<210> 124

<211> 14

<212>PRT

<213> Homo sapiens

<400> 124

Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met

1 5 10

<210> 125

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 125

Trp His Ala Pro Gln Thr Pro Tyr Trp Ala Ser Met

1 5 10

<210> 126

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 126

Trp His Ile Pro Pro Asn Ile Gly Arg Thr Phe Ser

1 5 10

<210> 127

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 127

Trp His Gln Thr Tyr Thr Ser Ser Leu Trp Glu Ser

1 5 10

<210> 128

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 128

Trp His Thr Gln Pro Ala His Val Val Thr Pro Met

1 5 10

<210> 129

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 129

Trp His Thr Ser Asp Pro Leu Pro Pro Ala Gln Pro

1 5 10

<210> 130

<211> 26

<212>PRT

<213> Homo sapiens

<400> 130

Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly

1 5 10 15

Lys Asn Ala Thr Gly Met Glu Leu Gly Trp

20 25

<210> 131

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 131

Ala Arg Trp Glu Leu Asn Leu

15

<210> 132

<211> 22

<212>PRT

<213> Homo sapiens

<400> 132

Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys

1 5 10 15

Gly Leu Ser Ala Thr Val

20

<210> 133

<211> 20

<212>PRT

<213> Homo sapiens

<400> 133

Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg

1 5 10 15

Gly Ala Pro Lys

20

<210> 134

<211> 20

<212>PRT

<213> Homo sapiens

<400> 134

Glu Lys Asp Arg Phe Ser Val Asn Leu Asp Val Ser His Phe Ser Pro

1 5 10 15

Glu Glu Leu Lys

20

<210> 135

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 135

Glu Pro Leu Tyr Gly Pro Tyr

15

<210> 136

<211> 20

<212>PRT

<213> Homo sapiens

<400> 136

Phe Asp Thr Gly Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser

1 5 10 15

Val Asn Leu Asp

20

<210> 137

<211> 26

<212>PRT

<213> Homo sapiens

<400> 137

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val

1 5 10 15

Gly Asp Glu Val Glu Leu Pro Cys Arg Ile

20 25

<210> 138

<211> 20

<212>PRT

<213> Homo sapiens

<400> 138

Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly

1 5 10 15

Ser Leu Pro Gln

20

<210> 139

<211> 15

<212>PRT

<213> Homo sapiens

<400> 139

Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn

1 5 10 15

<210> 140

<211> 20

<212>PRT

<213> Homo sapiens

<400> 140

Gly Val Leu Thr Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu

1 5 10 15

Arg Thr Ile Pro

20

<210> 141

<211> 23

<212>PRT

<213> Homo sapiens

<400> 141

Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn

1 5 10 15

Gly Lys Asp Gln Asp Gly Asp

20

<210> 142

<211> 20

<212>PRT

<213> Homo sapiens

<400> 142

His Gly Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala

1 5 10 15

Asp Val Asp Pro

20

<210> 143

<211> 20

<212>PRT

<213> Homo sapiens

<400> 143

His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly Phe Ile Ser Arg

1 5 10 15

Glu Phe His Arg

20

<210> 144

<211> 20

<212>PRT

<213> Homo sapiens

<400> 144

His Leu Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro

1 5 10 15

Phe Tyr Leu Arg

20

<210> 145

<211> 25

<212>PRT

<213> Homo sapiens

<400> 145

Ile Gly Glu Gly Lys Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser

1 5 10 15

Asp Glu Gly Gly Phe Thr Cys Phe Phe

20 25

<210> 146

<211> 20

<212>PRT

<213> Homo sapiens

<400> 146

Lys Tyr Arg Ile Pro Ala Asp Val Asp Pro Leu Thr Ile Thr Ser Ser

1 5 10 15

Leu Ser Ser Asp

20

<210> 147

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 147

Leu Ala Thr Pro Asn Pro Ser

15

<210> 148

<211> 20

<212>PRT

<213> Homo sapiens

<400> 148

Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr Val Asn

1 5 10 15

Gly Pro Arg Lys

20

<210> 149

<211> 24

<212>PRT

<213> Homo sapiens

<400> 149

Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Ala Pro Glu Tyr Arg

1 5 10 15

Gly Arg Thr Glu Leu Leu Lys Asp

20

<210> 150

<211> 20

<212>PRT

<213> Homo sapiens

<400> 150

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro

1 5 10 15

Phe His Ser Pro

20

<210> 151

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 151

Pro Glu Phe Ala Pro Trp Ala

15

<210> 152

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 152

Pro Glu Gln Pro Pro Ile His

15

<210> 153

<211> 25

<212>PRT

<213> Homo sapiens

<400> 153

Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu

1 5 10 15

Gly Lys Val Thr Leu Arg Ile Arg Asn

20 25

<210> 154

<211> 20

<212>PRT

<213> Homo sapiens

<400> 154

Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly Leu Ser

1 5 10 15

Glu Met Arg Leu

20

<210> 155

<211> 20

<212>PRT

<213> Homo sapiens

<400> 155

Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro

1 5 10 15

Pro Ser Gln Gly

20

<210> 156

<211> 20

<212>PRT

<213> Homo sapiens

<400> 156

Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala

1 5 10 15

Glu Gly Gln Arg

20

<210> 157

<211> 20

<212>PRT

<213> Homo sapiens

<400> 157

Gln Val Ser Gly Pro Glu Arg Thr Ile Pro Ile Thr Arg Glu Glu Lys

1 5 10 15

Pro Ala Val Thr

20

<210> 158

<211> 25

<212>PRT

<213> Homo sapiens

<400> 158

Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu

1 5 10 15

Asp Pro Phe Tyr Trp Val Ser Pro Gly

20 25

<210> 159

<211> 25

<212>PRT

<213> Homo sapiens

<400> 159

Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg Asp His Ser

1 5 10 15

Tyr Gln Glu Glu Ala Ala Met Glu Leu

20 25

<210> 160

<211> 20

<212>PRT

<213> Homo sapiens

<400> 160

Arg Arg Pro Phe Phe Pro Phe His Ser Pro Ser Arg Leu Phe Asp Gln

1 5 10 15

Phe Phe Gly Glu

20

<210> 161

<211> 24

<212>PRT

<213> Homo sapiens

<400> 161

Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Leu Gly Trp Tyr Arg Pro

1 5 10 15

Pro Phe Ser Arg Val Val His Leu

20

<210> 162

<211> 20

<212>PRT

<213> Homo sapiens

<400> 162

Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu Leu Glu Ser Asp

1 5 10 15

Leu Phe Pro Thr

20

<210> 163

<211> 20

<212>PRT

<213> Homo sapiens

<400> 163

Ser Thr Ser Leu Ser Pro Phe Tyr Leu Arg Pro Pro Ser Phe Leu Arg

1 5 10 15

Ala Pro Ser Trp

20

<210> 164

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 164

Ser Trp Tyr Ala Arg His Thr

15

<210> 165

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 165

Ser Trp Tyr Ala Arg His Tyr

15

<210> 166

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 166

Thr Ile Lys Asn Thr Phe Phe

15

<210> 167

<211> 14

<212>PRT

<213> Homo sapiens

<400> 167

Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg

1 5 10

<210> 168

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 168

Thr Pro Thr Phe Met Tyr Phe

15

<210> 169

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 169

Thr Ser Pro Ser Val Ala Tyr

15

<210> 170

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 170

Thr Thr Pro Leu Thr Asn Leu

15

<210> 171

<211> 13

<212>PRT

<213> Homo sapiens

<400> 171

Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu

1 5 10

<210> 172

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 172

Val Asp His Gln His Pro Ser

15

<210> 173

<211> 20

<212>PRT

<213> Homo sapiens

<400> 173

Val Lys Val Leu Gly Asp Val Ile Glu Val His Gly Lys His Glu Glu

1 5 10 15

Arg Gln Asp Glu

20

<210> 174

<211> 20

<212>PRT

<213> Homo sapiens

<400> 174

Val Ser His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp

1 5 10 15

Val Ile Glu Val

20

<210> 175

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 175

Tyr Ala Gln Pro Ser Glu Arg

15

<210> 176

<211> 15

<212>PRT

<213> Homo sapiens

<400> 176

Ala Ala Ala Gln Met Pro Ala Tyr Gln Glu Leu Val Glu Glu Ala

1 5 10 15

<210> 177

<211> 26

<212>PRT

<213> Cavia porcellus

<400> 177

Ala Ala Arg Thr Thr His Tyr Gly Ser Leu Pro Gln Lys Ser Gln Arg

1 5 10 15

Ser Gln Asp Glu Asn Pro Val Val His Phe

20 25

<210> 178

<211> 15

<212>PRT

<213> Homo sapiens

<400> 178

Ala Gly Val Thr Leu Ile Ser Pro Phe Val Gly Arg Ile Leu Asp

1 5 10 15

<210> 179

<211> 19

<212>PRT

<213> Homo sapiens

<400> 179

Ala Arg Arg Lys Val Ala Met Ala Thr Thr Tyr Tyr Phe Asp Tyr Trp

1 5 10 15

Gly Gln Gly

<210> 180

<211> 20

<212>PRT

<213> Homo sapiens

<400> 180

Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg

1 5 10 15

Thr Gln Asp Glu

20

<210> 181

<211> 15

<212>PRT

<213> Human herpes virus

<400> 181

Ala Arg Val Ala Glu His Pro Asp Ala Arg Leu Ala Trp Ala Arg

1 5 10 15

<210> 182

<211> 15

<212>PRT

<213> Homo sapiens

<400> 182

Ala Ser Asp Leu Glu Lys Ile His Leu Asp Glu Lys Ser Phe Arg

1 5 10 15

<210> 183

<211> 20

<212>PRT

<213> Homo sapiens

<400> 183

Ala Ser Gly Gly Thr Phe Ser Ser Phe Ala Ile Asn Trp Val Arg Gln

1 5 10 15

Ala Pro Gly Gln

20

<210> 184

<211> 19

<212>PRT

<213> Homo sapiens

<400> 184

Cys Phe Tyr Gln Lys Lys Glu Glu Asp Trp Ile Cys Cys Ala Cys Gln

1 5 10 15

Lys Thr Arg

<210> 185

<211> 15

<212>PRT

<213> Homo sapiens

<400> 185

Asp Ala Thr Thr Asn Pro Ser Leu Ile Leu Ala Ala Ala Gln Met

1 5 10 15

<210> 186

<211> 15

<212>PRT

<213> Homo sapiens

<400> 186

Asp Phe Leu Thr Ile Ser Pro Lys Leu Leu Gly Glu Leu Leu Gln

1 5 10 15

<210> 187

<211> 20

<212>PRT

<213> Homo sapiens

<400> 187

Asp His Ala Arg His Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile

1 5 10 15

Leu Asp Ser Ile

20

<210> 188

<211> 15

<212>PRT

<213> Homo sapiens

<400> 188

Asp Pro Gly Val Lys Ser Val Thr Lys Ile Tyr Asn Tyr Tyr Lys

1 5 10 15

<210> 189

<211> 15

<212>PRT

<213> Homo sapiens

<400> 189

Asp Gln Met Ala Val Glu Lys Leu Ser Asp Gly Ile Arg Lys Phe

1 5 10 15

<210> 190

<211> 23

<212>PRT

<213> Homo sapiens

<400> 190

Asp Arg Phe Ser Gly Ser Lys Ser Val Ser Thr Ala Ser Leu Thr Ile

1 5 10 15

Ser Gly Leu Gln Ala Glu Asp

20

<210> 191

<211> 19

<212>PRT

<213> Homo sapiens

<400> 191

Asp Arg Lys Tyr Ser Ile Cys Lys Ser Gly Cys Phe Tyr Gln Lys Lys

1 5 10 15

Glu Glu Asp

<210> 192

<211> 17

<212>PRT

<213> Homo sapiens

<400> 192

Asp Ser Tyr Thr Leu Thr Glu Glu Leu Ala Tyr Ala Glu Ile Arg Val

1 5 10 15

Lys

<210> 193

<211> 20

<212>PRT

<213> Homo sapiens

<400> 193

Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly

1 5 10 15

Thr Leu Ser Lys

20

<210> 194

<211> 15

<212>PRT

<213> Homo sapiens

<400> 194

Glu Ala Gly Ile Ser Lys Asp Arg Ile Leu Ile Lys Leu Ser Ser

1 5 10 15

<210> 195

<211> 21

<212>PRT

<213> Homo sapiens

<400> 195

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Ser Gly Tyr Ser Ile

1 5 10 15

Ser Arg Asp Val Tyr

20

<210> 196

<211> 15

<212>PRT

<213> Homo sapiens

<400> 196

Glu Lys Ser Phe Arg Trp Leu His Asn Glu Asp Gln Met Ala Val

1 5 10 15

<210> 197

<211> 17

<212>PRT

<213> Homo sapiens

<400> 197

Glu Asn Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys

1 5 10 15

Trp

<210> 198

<211> 20

<212>PRT

<213> Homo sapiens

<400> 198

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro Pro Pro Ser

20

<210> 199

<211> 22

<212>PRT

<213> Homo sapiens

<400> 199

Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Ala Ala Asp Tyr Ala

1 5 10 15

Gln Lys Phe Gln Gly Arg

20

<210> 200

<211> 15

<212>PRT

<213> Homo sapiens

<400> 200

Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu

1 5 10 15

<210> 201

<211> 15

<212>PRT

<213> Homo sapiens

<400> 201

Phe Gly Ala Glu Ile Leu Lys Lys Ile Pro Gly Arg Val Ser Thr

1 5 10 15

<210> 202

<211> 15

<212>PRT

<213> Homo sapiens

<400> 202

Phe His Ala Ile Asp Glu Tyr Lys Pro Gln Asp Ala Thr Thr Asn

1 5 10 15

<210> 203

<211> 15

<212>PRT

<213> Measles virus

<400> 203

Phe Ile Val Leu Ser Ile Ala Tyr Pro Thr Leu Ser Glu Ile Lys

1 5 10 15

<210> 204

<211> 20

<212>PRT

<213> Homo sapiens

<400> 204

Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu

1 5 10 15

Gly Gly Arg Asp

20

<210> 205

<211> 15

<212>PRT

<213> Homo sapiens

<400> 205

Phe Thr Thr Val Val Ala Asp Thr Gly Asp Phe His Ala Ile Asp

1 5 10 15

<210> 206

<211> 15

<212>PRT

<213> Homo sapiens

<400> 206

Gly Glu Leu Leu Gln Asp Asn Ala Lys Leu Val Pro Val Leu Ser

1 5 10 15

<210> 207

<211> 21

<212>PRT

<213> Homo sapiens

<400> 207

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Asn Trp Ile Arg Gln Ala Pro

1 5 10 15

Gly Lys Gly Leu Glu

20

<210> 208

<211> 21

<212>PRT

<213> Homo sapiens

<400> 208

Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala Phe Glu Gly

1 5 10 15

Thr Cys Val Ser Ile

20

<210> 209

<211> 15

<212>PRT

<213> Homo sapiens

<400> 209

Gly Ile His Cys Asn Met Thr Leu Leu Phe Ser Phe Ala Gln Ala

1 5 10 15

<210> 210

<211> 15

<212>PRT

<213> Human immunodeficiency virus

<400> 210

Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr

1 5 10 15

<210> 211

<211> 15

<212>PRT

<213> Homo sapiens

<400> 211

Gly Ile Arg Lys Phe Ala Ala Asp Ala Val Lys Leu Glu Arg Met

1 5 10 15

<210> 212

<211> 22

<212>PRT

<213> Homo sapiens

<400> 212

Gly Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met His Ser Leu Arg Ala

1 5 10 15

Glu Asp Thr Ala Val Tyr

20

<210> 213

<211> 20

<212>PRT

<213> Homo sapiens

<400> 213

Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly

1 5 10 15

Lys Asp Ser His

20

<210> 214

<211> 15

<212>PRT

<213> Homo sapiens

<400> 214

Gly Arg Ile Leu Asp Trp His Val Ala Asn Thr Asp Lys Lys Ser

1 5 10 15

<210> 215

<211> 15

<212>PRT

<213> Homo sapiens

<400> 215

Gly Arg Val Ser Thr Glu Val Asp Ala Arg Leu Ser Phe Asp Lys

1 5 10 15

<210> 216

<211> 20

<212>PRT

<213> Homo sapiens

<400> 216

Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly

1 5 10 15

Arg Asp Ser Arg

20

<210> 217

<211> 19

<212>PRT

<213> Homo sapiens

<400> 217

His Phe Ser Ile His Cys Cys Pro Pro Phe Thr Phe Leu Asn Ser Lys

1 5 10 15

Lys Glu Ile

<210> 218

<211> 20

<212>PRT

<213> Homo sapiens

<400> 218

His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly

1 5 10 15

Asp Arg Gly Ala

20

<210> 219

<211> 15

<212>PRT

<213> Homo sapiens

<400> 219

Ile Lys Leu Ser Ser Thr Trp Glu Gly Ile Gln Ala Gly Lys Glu

1 5 10 15

<210> 220

<211> 20

<212>PRT

<213> Homo sapiens

<400> 220

Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly

1 5 10 15

Leu Ser Leu Ser

20

<210> 221

<211> 18

<212>PRT

<213> Homo sapiens

<400> 221

Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met

1 5 10 15

Ala Arg

<210> 222

<211> 16

<212>PRT

<213> Homo sapiens

<400> 222

Lys Leu Glu Arg Met Leu Thr Glu Arg Met Phe Asn Ala Glu Asn Gly

1 5 10 15

<210> 223

<211> 15

<212>PRT

<213> Homo sapiens

<400> 223

Lys Leu Gly Gly Ser Gln Glu Asp Gln Ile Lys Asn Ala Ile Asp

1 5 10 15

<210> 224

<211> 15

<212>PRT

<213> Homo sapiens

<400> 224

Lys Asn Ala Ile Asp Lys Leu Phe Val Leu Phe Gly Ala Glu Ile

1 5 10 15

<210> 225

<211> 15

<212>PRT

<213> Homo sapiens

<400> 225

Leu Ser Phe Asp Lys Asp Ala Met Val Ala Arg Ala Arg Arg Leu

1 5 10 15

<210> 226

<211> 20

<212>PRT

<213> Homo sapiens

<400> 226

Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly

1 5 10 15

Tyr Gly Gly Arg

20

<210> 227

<211> 20

<212>PRT

<213> Homo sapiens

<400> 227

Leu Ser Tyr Ser His Ser Asp Tyr Asp Leu Gly Lys Arg Pro Thr Lys

1 5 10 15

Asp Ser Tyr Thr

20

<210> 228

<211> 15

<212>PRT

<213> Homo sapiens

<400> 228

Leu Val Glu Glu Ala Ile Ala Tyr Gly Arg Lys Leu Gly Gly Ser

1 5 10 15

<210> 229

<211> 26

<212>PRT

<213> Homo sapiens

<400> 229

Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys

1 5 10 15

Asn Ala Thr Gly Met Glu Val Gly Trp Tyr

20 25

<210> 230

<211> 25

<212>PRT

<213> Homo sapiens

<400> 230

Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr

1 5 10 15

Arg Gly Arg Thr Glu Leu Leu Lys Asp

20 25

<210> 231

<211> 20

<212>PRT

<213> Homo sapiens

<400> 231

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu

1 5 10 15

Ala Thr Ala Ser

20

<210> 232

<211> 15

<212>PRT

<213> Homo sapiens

<400> 232

Met Glu Ser Ala Leu Asp Gln Leu Lys Gln Phe Thr Thr Val Val

1 5 10 15

<210> 233

<211> 19

<212>PRT

<213> Homo sapiens

<400> 233

Met Ser Gln Lys Pro Ala Lys Glu Gly Pro Arg Leu Ser Lys Asn Gln

1 5 10 15

Lys Tyr Ser

<210> 234

<211> 15

<212>PRT

<213> Homo sapiens

<400> 234

Met Ser Ser Ser Pro Val Lys Arg Gln Arg Met Glu Ser Ala Leu

1 5 10 15

<210> 235

<211> 15

<212>PRT

<213> Human herpes virus

<400> 235

Asn Pro Val Met Glu Arg Phe Ala Ala His Ala Gly Asp Leu Val

1 5 10 15

<210> 236

<211> 20

<212>PRT

<213> Homo sapiens

<400> 236

Asn Ser Gly Tyr Ser Ile Ser Arg Asp Val Tyr Trp Gly Gln Gly Thr

1 5 10 15

Leu Val Thr Val

20

<210> 237

<211> 23

<212>PRT

<213> Homo sapiens

<400> 237

Pro Cys Arg Phe Asp Phe Pro Asp Glu Leu Arg Pro Ala Val Val His

1 5 10 15

Gly Val His Tyr Phe Asn Ser

20

<210> 238

<211> 20

<212>PRT

<213> Homo sapiens

<400> 238

Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His

1 5 10 15

Lys Gly Phe Lys

20

<210> 239

<211> 23

<212>PRT

<213> Homo sapiens

<400> 239

Pro Pro Phe Thr Phe Leu Asn Ser Lys Lys Glu Ile Val Asp Arg Lys

1 5 10 15

Tyr Ser Ile Cys Lys Ser Gly

20

<210> 240

<211> 20

<212>PRT

<213> Homo sapiens

<400> 240

Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His

1 5 10 15

Phe Phe Lys Asn

20

<210> 241

<211> 25

<212>PRT

<213> Homo sapiens

<400> 241

Pro Arg Pro Glu Val Arg Pro Pro Pro Ala Lys Gln Arg Pro Pro Gln

1 5 10 15

Lys Ser Lys Gln Gln Pro Arg Ser Ser

20 25

<210> 242

<211> 15

<212>PRT

<213> Homo sapiens

<400> 242

Gln Ala Gly Lys Glu Leu Glu Glu Gln His Gly Ile His Cys Asn

1 5 10 15

<210> 243

<211> 11

<212>PRT

<213> Homo sapiens

<400> 243

Gln Phe Gln Leu Val Glu Ser Gly Gly Gly Leu

1 5 10

<210> 244

<211> 22

<212>PRT

<213> Homo sapiens

<400> 244

Gln Lys Tyr Ser Glu His Phe Ser Ile His Cys Cys Pro Pro Phe Thr

1 5 10 15

Phe Leu Asn Ser Lys Lys

20

<210> 245

<211> 24

<212>PRT

<213> Homo sapiens

<400> 245

Gln Pro Arg Ser Ser Pro Leu Arg Gly Pro Gly Ala Ser Arg Gly Gly

1 5 10 15

Ser Pro Val Lys Ala Ser Arg Phe

20

<210> 246

<211> 24

<212>PRT

<213> Homo sapiens

<400> 246

Gln Gln His Pro Gly Lys Ala Pro Lys Val Met Ile Tyr Asp Val Thr

1 5 10 15

Lys Arg Pro Ser Gly Val Pro Asp

20

<210> 247

<211> 23

<212>PRT

<213> Homo sapiens

<400> 247

Gln Arg Pro Pro Gln Lys Ser Lys Gln Gln Pro Arg Ser Ser Pro Leu

1 5 10 15

Arg Gly Pro Gly Ala Ser Arg

20

<210> 248

<211> 12

<212>PRT

<213> Homo sapiens

<400> 248

Gln Ser Val Leu Thr Gln Pro Arg Ser Val Ser Gly

1 5 10

<210> 249

<211> 13

<212>PRT

<213> Homo sapiens

<400> 249

Gln Ser Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser

1 5 10

<210> 250

<211> 20

<212>PRT

<213> Homo sapiens

<400> 250

Gln Thr Trp Gly Thr Gly Ile Glu Thr Val Phe Gly Gly Gly Thr Lys

1 5 10 15

Val Thr Val Leu

20

<210> 251

<211> 21

<212>PRT

<213> Homo sapiens

<400> 251

Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Lys Val Ala

1 5 10 15

Met Ala Thr Thr Tyr

20

<210> 252

<211> 15

<212>PRT

<213> Homo sapiens

<400> 252

Arg Ala Arg Arg Leu Ile Glu Leu Tyr Lys Glu Ala Gly Ile Ser

1 5 10 15

<210> 253

<211> 20

<212>PRT

<213> Homo sapiens

<400> 253

Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly

1 5 10 15

Gly Arg Ala Ser

20

<210> 254

<211> 20

<212>PRT

<213> Homo sapiens

<400> 254

Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr

1 5 10 15

Gly Ser Leu Pro

20

<210> 255

<211> 19

<212>PRT

<213> Homo sapiens

<400> 255

Arg Leu Ser Lys Asn Gln Lys Tyr Ser Glu His Phe Ser Ile His Cys

1 5 10 15

Cys Pro Pro

<210> 256

<211> 19

<212>PRT

<213> Homo sapiens

<400> 256

Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala

1 5 10 15

His Lys Gly

<210> 257

<211> 15

<212>PRT

<213> Homo sapiens

<400> 257

Ser Phe Ala Gln Ala Val Ala Cys Ala Glu Ala Gly Val Thr Leu

1 5 10 15

<210> 258

<211> 24

<212>PRT

<213> Homo sapiens

<400> 258

Ser Gly Cys Phe Tyr Gln Lys Lys Glu Glu Asp Trp Ile Cys Cys Ala

1 5 10 15

Cys Gln Lys Thr Arg Thr Ser Arg

20

<210> 259

<211> 20

<212>PRT

<213> Homo sapiens

<400> 259

Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly

1 5 10 15

Phe Leu Pro Arg

20

<210> 260

<211> 20

<212>PRT

<213> Homo sapiens

<400> 260

Ser Gln Arg His Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp

1 5 10 15

His Ala Arg His

20

<210> 261

<211> 20

<212>PRT

<213> Homo sapiens

<400> 261

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Gly Asn Ala Lys Asn Ser

1 5 10 15

Leu Tyr Leu Gln

20

<210> 262

<211> 19

<212>PRT

<213> Homo sapiens

<400> 262

Ser Tyr Ala Gly Gly Ser Ala Cys Val Phe Gly Thr Gly Thr Lys Leu

1 5 10 15

Thr Val Leu

<210> 263

<211> 15

<212>PRT

<213> Homo sapiens

<400> 263

Thr Asp Lys Lys Ser Tyr Glu Pro Leu Glu Asp Pro Gly Val Lys

1 5 10 15

<210> 264

<211> 19

<212>PRT

<213> Homo sapiens

<400> 264

Thr Phe Leu Asn Ser Lys Lys Glu Ile Val Asp Arg Lys Tyr Ser Ile

1 5 10 15

Cys Lys Ser

<210> 265

<211> 15

<212>PRT

<213> Homo sapiens

<400> 265

Thr Gly Glu Ile Lys Ala Leu Ala Gly Cys Asp Phe Leu Thr Ile

1 5 10 15

<210> 266

<211> 15

<212>PRT

<213> Homo sapiens

<400> 266

Thr Ile Val Met Gly Ala Ser Phe Arg Asn Thr Gly Glu Ile Lys

1 5 10 15

<210> 267

<211> 20

<212>PRT

<213> Homo sapiens

<400> 267

Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His

1 5 10 15

Val Ser Leu Leu

20

<210> 268

<211> 15

<212>PRT

<213> Human herpes virus

<400> 268

Val Pro Val Leu Ala Phe Asp Ala Ala Arg Leu Arg Leu Leu Glu

1 5 10 15

<210> 269

<211> 15

<212>PRT

<213> Homo sapiens

<400> 269

Val Pro Val Leu Ser Ala Lys Ala Ala Gln Ala Ser Asp Leu Glu

1 5 10 15

<210> 270

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 270

Tyr Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

Arg Thr Pro Pro

20

<210> 271

<211> 15

<212>PRT

<213> Homo sapiens

<400> 271

Tyr Asn Tyr Tyr Lys Lys Phe Ser Tyr Lys Thr Ile Val Met Gly

1 5 10 15

<210> 272

<211> 15

<212>PRT

<213> Homo sapiens

<400> 272

Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly

1 5 10 15

<210> 273

<211> 20

<212>PRT

<213> Cavia porcellus

<400> 273

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala

1 5 10 15

Thr Ala Ser Thr

20

<210> 274

<211> 38

<212>PRT

<213> Homo sapiens

<400> 274

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala

1 5 10 15

Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg His

20 25 30

Arg Asp Thr Gly Ile Leu

35

<210> 275

<211> 17

<212>PRT

<213> Human herpes virus

<400> 275

Asp Ala Tyr Pro Cys Tyr Phe Phe Lys Ser Ala Cys Arg Pro Arg Ala

1 5 10 15

Pro

<210> 276

<211> 17

<212>PRT

<213> Homo sapiens

<400> 276

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

Thr

<210> 277

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 277

Glu Ala Gly Ala Gly Gly Gly Ala

15

<210> 278

<211> 12

<212>PRT

<213> Bos taurus

<400> 278

Glu Asp Lys Gly Ala Cys Leu Leu Pro Lys Ile Glu

1 5 10

<210> 279

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 279

Glu Asn Pro Lys Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 280

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 280

Glu Pro Ala Arg Ser Arg Ser Arg

15

<210> 281

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 281

Glu Pro Met Thr Pro His Gln Trp Ile Thr Leu Tyr Arg Ser Tyr

1 5 10 15

<210> 282

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 282

Phe Cys Pro Pro Ile Leu Pro Tyr Ser Ala Trp Cys Pro Val Pro

1 5 10 15

<210> 283

<211> 20

<212>PRT

<213> Mus musculus

<400> 283

Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys

1 5 10 15

Gly Phe Lys Gly

20

<210> 284

<211> 12

<212>PRT

<213> Homo sapiens

<400> 284

Gly Lys Trp Leu Gly His Pro Asp Lys Phe Val Gly

1 5 10

<210> 285

<211> 19

<212>PRT

<213> Homo sapiens

<400> 285

Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His

1 5 10 15

Gly Phe Leu

<210> 286

<211> 20

<212>PRT

<213> Homo sapiens

<400> 286

Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His

1 5 10 15

Gly Phe Leu Pro

20

<210> 287

<211> 15

<212>PRT

<213> Homo sapiens

<400> 287

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys

1 5 10 15

<210> 288

<211> 22

<212>PRT

<213> Homo sapiens

<400> 288

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser

1 5 10 15

His Gly Arg Thr Gln Asp

20

<210> 289

<211> 15

<212>PRT

<213> Human papillomavirus

<400> 289

Ile Gly Gly Arg Val His Phe Phe Lys Asp Ile Ser Pro Ile Ala

1 5 10 15

<210> 290

<211> 11

<212>PRT

<213> Homo sapiens

<400> 290

Lys Leu Ser Asp Gly Ile Arg Lys Phe Ala Ala

1 5 10

<210> 291

<211> 16

<212>PRT

<213> Homo sapiens

<400> 291

Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly

1 5 10 15

<210> 292

<211> 21

<212>PRT

<213> Homo sapiens

<400> 292

Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe

1 5 10 15

Lys Asn Ile Val Thr

20

<210> 293

<211> 21

<212>PRT

<213> Homo sapiens

<400> 293

Lys Ser His Gly Arg Thr Gln Asp Gln Asp Pro Val Val His Phe Phe

1 5 10 15

Lys Asn Ile Val Thr

20

<210> 294

<211> 9

<212>PRT

<213> Homo sapiens

<400> 294

Leu Leu Phe Ser Phe Ala Gln Ala Val

15

<210> 295

<211> 20

<212>PRT

<213> Cavia porcellus

<400> 295

Met Asp His Ala Arg His Gly Phe Leu Pro Arg His Arg Asp Thr Gly

1 5 10 15

Ile Leu Asp Ser

20

<210> 296

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 296

Met Pro Val Ser Arg Leu Cys Ile Glu Leu Asp Trp Cys Pro Pro

1 5 10 15

<210> 297

<211> 20

<212>PRT

<213> Homo sapiens

<400> 297

Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp

1 5 10 15

Gly Ala Glu Gly

20

<210> 298

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 298

Arg Gly Thr Gln Glu Trp Thr Glu Leu Trp Val Ser Phe Arg Ala

1 5 10 15

<210> 299

<211> 16

<212>PRT

<213> Homo sapiens

<400> 299

Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys

1 5 10 15

<210> 300

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 300

Ser Arg Gly Ser His Glu Trp Ala Val Leu Phe Arg Phe Tyr Tyr

1 5 10 15

<210> 301

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 301

Ser Ser Ala Lys Ser His Cys Tyr Ala Phe Cys Ser Gly Leu Pro

1 5 10 15

<210> 302

<211> 12

<212>PRT

<213> Homo sapiens

<400> 302

Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu

1 5 10

<210> 303

<211> 10

<212>PRT

<213> Homo sapiens

<400> 303

Thr Gln Asp Glu Asn Pro Val Val His Phe

1 5 10

<210> 304

<211> 18

<212>PRT

<213> Homo sapiens

<400> 304

Thr Gln Asp Gln Asp Pro Val Val His Phe Phe Lys Asn Ile Val Thr

1 5 10 15

Pro Arg

<210> 305

<211> 12

<212>PRT

<213> Bos taurus

<400> 305

Thr Ser Val Phe Asp Lys Leu Lys His Leu Val Asp

1 5 10

<210> 306

<211> 21

<212>PRT

<213> Mus musculus

<400> 306

Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser

1 5 10 15

Gln Gly Lys Gly Arg

20

<210> 307

<211> 10

<212>PRT

<213> Homo sapiens

<400> 307

Val Val His Phe Phe Lys Asn Ile Val Thr

1 5 10

<210> 308

<211> 15

<212>PRT

<213> Homo sapiens

<400> 308

Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Gln

1 5 10 15

<210> 309

<211> 17

<212>PRT

<213> Homo sapiens

<400> 309

Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu

1 5 10 15

Pro

<210> 310

<211> 9

<212>PRT

<213> Homo sapiens

<400> 310

Asp Tyr Lys Ser Ala His Lys Gly Phe

15

<210> 311

<211> 15

<212>PRT

<213> Homo sapiens

<400> 311

Gly Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser

1 5 10 15

<210> 312

<211> 9

<212>PRT

<213> Homo sapiens

<400> 312

Lys Tyr Leu Ala Thr Ala Ser Thr Met

15

<210> 313

<211> 21

<212>PRT

<213> Homo sapiens

<400> 313

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

Thr Pro Pro Pro Ser

20

<210> 314

<211> 12

<212>PRT

<213> Homo sapiens

<400> 314

Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro

1 5 10

<210> 315

<211> 21

<212>PRT

<213> Homo sapiens

<400> 315

Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His

1 5 10 15

Ser Leu Glu Arg Val

20

<210> 316

<211> 18

<212>PRT

<213> Homo sapiens

<400> 316

Tyr Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly

1 5 10 15

Gly Gln

<210> 317

<211> 20

<212>PRT

<213> Homo sapiens

<400> 317

Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro

1 5 10 15

Gly Phe Gly Tyr

20

<210> 318

<211> 19

<212>PRT

<213> Homo sapiens

<400> 318

Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Ala Ala Arg Thr

1 5 10 15

Ala His Tyr

<210> 319

<211> 23

<212>PRT

<213> Homo sapiens

<400> 319

Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg Ile Arg Asn Val Arg

1 5 10 15

Phe Ser Asp Glu Gly Gly Phe

20

<210> 320

<211> 21

<212>PRT

<213> Homo sapiens

<400> 320

Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg

1 5 10 15

Gly Ser Gly Lys Asp

20

<210> 321

<211> 20

<212>PRT

<213> Homo sapiens

<400> 321

Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu

1 5 10 15

Val Gly Trp Tyr

20

<210> 322

<211> 23

<212>PRT

<213> Homo sapiens

<400> 322

Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly

1 5 10 15

Lys Val Thr Leu Arg Ile Arg

20

<210> 323

<211> 20

<212>PRT

<213> Homo sapiens

<400> 323

Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly

1 5 10 15

Arg Ala Ser Asp

20

<210> 324

<211> 22

<212>PRT

<213> Homo sapiens

<400> 324

Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser

1 5 10 15

Leu Glu Arg Val Cys His

20

<210> 325

<211> 15

<212>PRT

<213> Herpes simplex virus

<400> 325

Gly Gly Arg Arg Leu Phe Phe Val Lys Ala His Val Arg Glu Ser

1 5 10 15

<210> 326

<211> 20

<212>PRT

<213> Homo sapiens

<400> 326

Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu

1 5 10 15

Gly Gln Arg Pro

20

<210> 327

<211> 24

<212>PRT

<213> Homo sapiens

<400> 327

Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro

1 5 10 15

Gly Phe Gly Tyr Gly Gly Arg Ala

20

<210> 328

<211> 23

<212>PRT

<213> Homo sapiens

<400> 328

Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His

1 5 10 15

Leu Tyr Arg Asn Gly Lys Asp

20

<210> 329

<211> 22

<212>PRT

<213> Homo sapiens

<400> 329

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val

1 5 10 15

Gly Asp Glu Val Glu Leu

20

<210> 330

<211> 15

<212>PRT

<213> Homo sapiens

<400> 330

Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg

1 5 10 15

<210> 331

<211> 26

<212>PRT

<213> Homo sapiens

<400> 331

Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly

1 5 10 15

Arg Asp Ser Arg Ser Gly Ser Pro Met Ala

20 25

<210> 332

<211> 19

<212>PRT

<213> Homo sapiens

<400> 332

His Ala Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser Gln

1 5 10 15

Gly His Arg

<210> 333

<211> 17

<212>PRT

<213> Homo sapiens

<400> 333

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile

1 5 10 15

Thr

<210> 334

<211> 15

<212>PRT

<213> Homo sapiens

<400> 334

Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr

1 5 10 15

<210> 335

<211> 20

<212>PRT

<213> Homo sapiens

<400> 335

Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu Ala Gln

1 5 10 15

Leu Glu Lys Ser

20

<210> 336

<211> 20

<212>PRT

<213> Homo sapiens

<400> 336

Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe

1 5 10 15

Gly Asp Tyr Lys

20

<210> 337

<211> 19

<212>PRT

<213> Homo sapiens

<400> 337

Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro

1 5 10 15

Pro Pro Ser

<210> 338

<211> 20

<212>PRT

<213> Homo sapiens

<400> 338

Pro Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr

1 5 10 15

Pro Arg Thr Pro

20

<210> 339

<211> 20

<212>PRT

<213> Homo sapiens

<400> 339

Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe

1 5 10 15

Gly Gly Asp Arg

20

<210> 340

<211> 19

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 340

Gln Ala His Ser Leu Glu Arg Val Ser His Ser Leu Gly Lys Trp Leu

1 5 10 15

Gly His Pro

<210> 341

<211> 20

<212>PRT

<213> Homo sapiens

<400> 341

Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp

1 5 10 15

Arg Gly Ala Pro

20

<210> 342

<211> 20

<212>PRT

<213> Homo sapiens

<400> 342

Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys

1 5 10 15

Asp Ser His His

20

<210> 343

<211> 20

<212>PRT

<213> Homo sapiens

<400> 343

Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr

1 5 10 15

Gln Asp Glu Asn

20

<210> 344

<211> 20

<212>PRT

<213> Homo sapiens

<400> 344

Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr

1 5 10 15

Leu Ser Lys Ile

20

<210> 345

<211> 25

<212>PRT

<213> Homo sapiens

<400> 345

Ala Ala Arg Thr Thr His Tyr Gly Ser Leu Pro Gln Lys Ser Gln Arg

1 5 10 15

Ser Gln Asp Gln Asn Pro Val His Phe

20 25

<210> 346

<211> 25

<212>PRT

<213> Bos taurus

<400> 346

Ala Glu Tyr Arg Gly Arg Val Ser Leu Val Glu Asp His Ile Ala Glu

1 5 10 15

Gly Ser Val Ala Val Arg Ile Gln Glu

20 25

<210> 347

<211> 17

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 347

Ala Lys Pro Val Val His Leu Phe Ala Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro

<210> 348

<211> 26

<212>PRT

<213> Bos taurus

<400> 348

Ala Pro Phe Asp Val Ile Gly Pro Gln Glu Pro Ile Leu Ala Val Val

1 5 10 15

Gly Glu Asp Ala Glu Leu Pro Cys Arg Leu

20 25

<210> 349

<211> 11

<212>PRT

<213> Homo sapiens

<400> 349

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe

1 5 10

<210> 350

<211> 19

<212>PRT

<213> Homo sapiens

<400> 350

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Lys Tyr Leu Ala Thr

1 5 10 15

Ala Ser Thr

<210> 351

<211> 20

<212>PRT

<213> Mus musculus

<400> 351

Ala Ser Gln Lys Arg Pro Ser Gln Arg Ser Lys Tyr Leu Ala Thr Ala

1 5 10 15

Ser Thr Met Asp

20

<210> 352

<211> 26

<212>PRT

<213> Bos taurus

<400> 352

Ala Val Val Gly Glu Asp Ala Glu Leu Pro Cys Arg Leu Ser Pro Asn

1 5 10 15

Val Ser Ala Lys Gly Met Glu Leu Arg Trp

20 25

<210> 353

<211> 11

<212>PRT

<213> Homo sapiens

<400> 353

Asp Glu Asn Pro Val Val His Phe Phe Lys Asn

1 5 10

<210> 354

<211> 17

<212>PRT

<213> Homo sapiens

<400> 354

Glu Asn Pro Val Val His Glu Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro

<210> 355

<211> 14

<212>PRT

<213> Homo sapiens

<400> 355

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10

<210> 356

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 356

Glu Asn Pro Val Val His Phe Phe Leu Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 357

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 357

Glu Asn Pro Val Val His Phe Phe Arg Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 358

<211> 19

<212>PRT

<213> Homo sapiens

<400> 358

Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Gln Gly Gln Lys Pro

1 5 10 15

Gly Phe Gly

<210> 359

<211> 23

<212>PRT

<213> Homo sapiens

<400> 359

Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser

1 5 10 15

Gly Ser Pro Met Ala Arg Arg

20

<210> 360

<211> 25

<212>PRT

<213> Bos taurus

<400> 360

Ile Ala Glu Gly Ser Val Ala Val Arg Ile Gln Glu Val Lys Ala Ser

1 5 10 15

Asp Asp Gly Glu Tyr Arg Cys Phe Phe

20 25

<210> 361

<211> 25

<212>PRT

<213> Bos taurus

<400> 361

Lys Ala Ser Asp Asp Gly Glu Tyr Arg Cys Phe Phe Arg Gln Asp Glu

1 5 10 15

Asn Tyr Glu Glu Ala Ile Val His Leu

20 25

<210> 362

<211> 22

<212>PRT

<213> Homo sapiens

<400> 362

Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe

1 5 10 15

Lys Asn Ile Val Thr Pro

20

<210> 363

<211> 17

<212>PRT

<213> Homo sapiens

<400> 363

Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro

1 5 10 15

Arg

<210> 364

<211> 14

<212>PRT

<213> Homo sapiens

<400> 364

Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10

<210> 365

<211> 19

<212>PRT

<213> Homo sapiens

<400> 365

Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

Arg Thr Pro

<210> 366

<211> 20

<212>PRT

<213> Bos taurus

<400> 366

Arg Gln Asp Glu Asn Tyr Glu Glu Ala Ile Val His Leu Lys Val Ala

1 5 10 15

Ala Leu Gly Ser

20

<210> 367

<211> 23

<212>PRT

<213> Bos taurus

<400> 367

Arg Trp Phe Arg Glu Lys Val Ser Pro Ala Val Phe Val Ser Arg Glu

1 5 10 15

Gly Gln Glu Gln Glu Gly Glu

20

<210> 368

<211> 24

<212>PRT

<213> Bos taurus

<400> 368

Ser Pro Asn Val Ser Ala Lys Gly Met Glu Leu Arg Trp Phe Arg Glu

1 5 10 15

Lys Val Ser Pro Ala Val Phe Val

20

<210> 369

<211> 18

<212>PRT

<213> Bos taurus

<400> 369

Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly

1 5 10 15

Ser Pro

<210> 370

<211> 13

<212>PRT

<213> Homo sapiens

<400> 370

Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Glu

1 5 10

<210> 371

<211> 24

<212>PRT

<213> Bos taurus

<400> 371

Val Ser Arg Glu Gly Gln Glu Gln Glu Gly Glu Met Ala Glu Tyr Arg

1 5 10 15

Gly Arg Val Ser Leu Val Glu Asp

20

<210> 372

<211> 23

<212>PRT

<213> Homo sapiens

<400> 372

Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu

1 5 10 15

Ser Leu Ser Arg Phe Ser Trp

20

<210> 373

<211> 18

<212>PRT

<213> Homo sapiens

<400> 373

Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr Glu Glu Glu

1 5 10 15

Glu Arg

<210> 374

<211> 19

<212>PRT

<213> Homo sapiens

<400> 374

Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro

1 5 10 15

Gly Phe Gly

<210> 375

<211> 19

<212>PRT

<213> Homo sapiens

<400> 375

Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro

1 5 10 15

Gly Phe Gly

<210> 376

<211> 14

<212>PRT

<213> Homo sapiens

<400> 376

His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser

1 5 10

<210> 377

<211> 24

<212>PRT

<213> Homo sapiens

<400> 377

Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe

1 5 10 15

Lys Asn Ile Val Thr Pro Arg Thr

20

<210> 378

<211> 21

<212>PRT

<213> Homo sapiens

<400> 378

Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln Gly Thr Gly Ala

1 5 10 15

Ala Asp Asp Ser Gly

20

<210> 379

<211> 20

<212>PRT

<213> Homo sapiens

<400> 379

Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg Ile Arg

1 5 10 15

Asn Val Arg Phe

20

<210> 380

<211> 20

<212>PRT

<213> Homo sapiens

<400> 380

Gln Ala Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile

1 5 10 15

Gly Glu Gly Lys

20

<210> 381

<211> 20

<212>PRT

<213> Homo sapiens

<400> 381

Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu

1 5 10 15

Asp Pro Phe Tyr

20

<210> 382

<211> 20

<212>PRT

<213> Homo sapiens

<400> 382

Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp

1 5 10 15

Gln Asp Gly Asp

20

<210> 383

<211> 20

<212>PRT

<213> Homo sapiens

<400> 383

Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln

1 5 10 15

Glu Glu Ala Ala

20

<210> 384

<211> 20

<212>PRT

<213> Homo sapiens

<400> 384

Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro

1 5 10 15

Met Ala Arg Arg

20

<210> 385

<211> 19

<212>PRT

<213> Homo sapiens

<400> 385

Ser Arg Gly Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys

1 5 10 15

Leu Gly Lys

<210> 386

<211> 20

<212>PRT

<213> Homo sapiens

<400> 386

Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe

1 5 10 15

Thr Cys Phe Phe

20

<210> 387

<211> 20

<212>PRT

<213> Homo sapiens

<400> 387

Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg

1 5 10 15

Gly Arg Thr Glu

20

<210> 388

<211> 9

<212>PRT

<213> Homo sapiens

<400> 388

Leu Met Trp Ala Lys Ile Gly Pro Val

15

<210> 389

<211> 9

<212>PRT

<213> Homo sapiens

<400> 389

Ser Leu Leu Leu Glu Leu Glu Glu Val

15

<210> 390

<211> 9

<212>PRT

<213> Homo sapiens

<400> 390

Val Leu Phe Ser Ser Asp Phe Arg Ile

15

<210> 391

<211> 12

<212>PRT

<213> Homo sapiens

<400> 391

Ala Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys

1 5 10

<210> 392

<211> 12

<212>PRT

<213> Homo sapiens

<400> 392

Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro

1 5 10

<210> 393

<211> 12

<212>PRT

<213> Homo sapiens

<400> 393

Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg Asp His

1 5 10

<210> 394

<211> 12

<212>PRT

<213> Homo sapiens

<400> 394

Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu

1 5 10

<210> 395

<211> 12

<212>PRT

<213> Homo sapiens

<400> 395

Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val

1 5 10

<210> 396

<211> 12

<212>PRT

<213> Homo sapiens

<400> 396

Glu Glu Ala Ala Met Glu Leu Lys Val Glu Asp Pro

1 5 10

<210> 397

<211> 12

<212>PRT

<213> Homo sapiens

<400> 397

Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser

1 5 10

<210> 398

<211> 12

<212>PRT

<213> Homo sapiens

<400> 398

Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro

1 5 10

<210> 399

<211> 12

<212>PRT

<213> Homo sapiens

<400> 399

Gly Glu Gly Lys Val Thr Leu Arg Ile Arg Asn Val

1 5 10

<210> 400

<211> 12

<212>PRT

<213> Homo sapiens

<400> 400

Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp

1 5 10

<210> 401

<211> 12

<212>PRT

<213> Homo sapiens

<400> 401

Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu

1 5 10

<210> 402

<211> 12

<212>PRT

<213> Homo sapiens

<400> 402

Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro

1 5 10

<210> 403

<211> 19

<212>PRT

<213> Homo sapiens

<400> 403

Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly

1 5 10 15

Arg Gly Leu

<210> 404

<211> 12

<212>PRT

<213> Homo sapiens

<400> 404

Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu

1 5 10

<210> 405

<211> 12

<212>PRT

<213> Homo sapiens

<400> 405

Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr

1 5 10

<210> 406

<211> 19

<212>PRT

<213> Homo sapiens

<400> 406

Met Asp His Ala Arg His Gly Phe Leu Pro Arg His Arg Asp Thr Gly

1 5 10 15

Ile Leu Asp

<210> 407

<211> 12

<212>PRT

<213> Homo sapiens

<400> 407

Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys

1 5 10

<210> 408

<211> 12

<212>PRT

<213> Homo sapiens

<400> 408

Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn

1 5 10

<210> 409

<211> 19

<212>PRT

<213> Homo sapiens

<400> 409

Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp

1 5 10 15

Gly Ala Glu

<210> 410

<211> 12

<212>PRT

<213> Homo sapiens

<400> 410

Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly Arg

1 5 10

<210> 411

<211> 12

<212>PRT

<213> Homo sapiens

<400> 411

Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg

1 5 10

<210> 412

<211> 19

<212>PRT

<213> Homo sapiens

<400> 412

Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser

1 5 10 15

Ala His Lys

<210> 413

<211> 12

<212>PRT

<213> Homo sapiens

<400> 413

Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro

1 5 10

<210> 414

<211> 19

<212>PRT

<213> Homo sapiens

<400> 414

Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro

1 5 10 15

Met Ala Arg

<210> 415

<211> 19

<212>PRT

<213> Homo sapiens

<400> 415

Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val

1 5 10 15

Val His Phe

<210> 416

<211> 12

<212>PRT

<213> Homo sapiens

<400> 416

Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly

1 5 10

<210> 417

<211> 12

<212>PRT

<213> Homo sapiens

<400> 417

Ser Ser Tyr Ala Gly Gln Phe Arg Val Ile Gly Pro

1 5 10

<210> 418

<211> 9

<212>PRT

<213> Homo sapiens

<400> 418

Ser Trp Gly Ala Glu Gly Gln Arg Pro

15

<210> 419

<211> 10

<212>PRT

<213> Homo sapiens

<400> 419

Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly

1 5 10

<210> 420

<211> 12

<212>PRT

<213> Homo sapiens

<400> 420

Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu

1 5 10

<210> 421

<211> 12

<212>PRT

<213> Homo sapiens

<400> 421

Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val

1 5 10

<210> 422

<211> 12

<212>PRT

<213> Homo sapiens

<400> 422

Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp

1 5 10

<210> 423

<211> 8

<212>PRT

<213> Homo sapiens

<400> 423

Trp Gly Ala Glu Gly Gln Arg Pro

15

<210> 424

<211> 10

<212>PRT

<213> Homo sapiens

<400> 424

Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe

1 5 10

<210> 425

<211> 5

<212>PRT

<213> Homo sapiens

<400> 425

Ala Ala Met Glu Leu

15

<210> 426

<211> 5

<212>PRT

<213> Homo sapiens

<400> 426

Ala Asp Ala Arg Met

15

<210> 427

<211> 5

<212>PRT

<213> Homo sapiens

<400> 427

Ala His Arg Glu Thr

15

<210> 428

<211> 15

<212>PRT

<213> Bacillus subtilis

<400> 428

Ala Leu Ala Val Leu His Phe Tyr Pro Asp Lys Gly Ala Lys Asn

1 5 10 15

<210> 429

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 429

Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Thr Tyr Glu Glu Glu

1 5 10 15

Glu Arg Gln Arg Gly

20

<210> 430

<211> 21

<212>PRT

<213> Homo sapiens

<400> 430

Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr Glu Glu Glu

1 5 10 15

Glu Arg Gln Arg Gly

20

<210> 431

<211> 21

<212>PRT

<213> Homo sapiens

<400> 431

Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg His Arg

1 5 10 15

Asp Thr Gly Ile Leu

20

<210> 432

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 432

Asp Phe Ala Arg Val His Phe Ile Arg Ala Leu His Gly Ser Gly

1 5 10 15

<210> 433

<211> 15

<212>PRT

<213> Haemophilus influenzae

<400> 433

Asp Phe Ala Arg Val His Phe Ile Ser Ala Leu His Gly Ser Gly

1 5 10 15

<210> 434

<211> 21

<212>PRT

<213> Homo sapiens

<400> 434

Asp Pro Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Val Lys

1 5 10 15

Asp Thr Asp Lys Gly

20

<210> 435

<211> 21

<212>PRT

<213> Homo sapiens

<400> 435

Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe Ser Tyr Asp Val Lys

1 5 10 15

Met Lys Glu Lys Gly

20

<210> 436

<211> 20

<212>PRT

<213> Homo sapiens

<400> 436

Gly Asn Phe Pro Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser

1 5 10 15

Ser Glu Leu Asn

20

<210> 437

<211> 19

<212>PRT

<213> Homo sapiens

<400> 437

Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg

1 5 10 15

Gln Arg Gly

<210> 438

<211> 15

<212>PRT

<213> Homo sapiens

<400> 438

Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly

1 5 10 15

<210> 439

<211> 18

<212>PRT

<213> Cavia porcellus

<400> 439

Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser

1 5 10 15

Gly Ser

<210> 440

<211> 5

<212>PRT

<213> Homo sapiens

<400> 440

His Arg Thr Phe Glu

15

<210> 441

<211> 5

<212>PRT

<213> Homo sapiens

<400> 441

His Ser Tyr Gln Glu

15

<210> 442

<211> 6

<212>PRT

<213> Homo sapiens

<400> 442

Lys Thr Gly Gln Phe Leu

15

<210> 443

<211> 21

<212>PRT

<213> Homo sapiens

<400> 443

Lys Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly

1 5 10 15

His Asp Thr Val Ser

20

<210> 444

<211> 20

<212>PRT

<213> Homo sapiens

<400> 444

Leu Val Lys Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp

1 5 10 15

Met Asp His Glu

20

<210> 445

<211> 16

<212>PRT

<213> Homo sapiens

<400> 445

Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser

1 5 10 15

<210> 446

<211> 24

<212>PRT

<213> Cavia porcellus

<400> 446

Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser Gly Arg

1 5 10 15

Ser Gln Asp Glu Asn Pro Val Val

20

<210> 447

<211> 18

<212>PRT

<213> Homo sapiens

<400> 447

Pro Lys Ser Gly His Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly

1 5 10 15

Gln Gly

<210> 448

<211> 19

<212>PRT

<213> Homo sapiens

<400> 448

Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Leu Leu Gly Asp

1 5 10 15

Ser Ala Leu

<210> 449

<211> 40

<212>PRT

<213> Homo sapiens

<400> 449

Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp

1 5 10 15

Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser

20 25 30

Asp Tyr Lys Ser Ala His Lys Gly

35 40

<210> 450

<211> 5

<212>PRT

<213> Homo sapiens

<400> 450

Gln Ala Pro Glu Tyr

15

<210> 451

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 451

Gln Arg Cys Arg Val His Phe Leu Arg Asn Val Leu Ala Gln Val

1 5 10 15

<210> 452

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 452

Gln Arg Cys Arg Val His Phe Met Arg Asn Leu Tyr Thr Ala Val

1 5 10 15

<210> 453

<211> 19

<212>PRT

<213> Homo sapiens

<400> 453

Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro Asp Arg

1 5 10 15

Phe Ser Gly

<210> 454

<211> 16

<212>PRT

<213> Homo sapiens

<400> 454

Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys

1 5 10 15

<210> 455

<211> 20

<212>PRT

<213> Homo sapiens

<400> 455

Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro

1 5 10 15

Met Ala Arg Arg

20

<210> 456

<211> 21

<212>PRT

<213> Homo sapiens

<400> 456

Ser Lys Lys Phe Leu Lys Ile Met Phe Ser Tyr Asn Asn Lys Glu Leu

1 5 10 15

Ile Ile Asn Glu Thr

20

<210> 457

<211> 19

<212>PRT

<213> Cavia porcellus

<400> 457

Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Lys Pro Gly Phe

1 5 10 15

Gly Tyr Gly

<210> 458

<211> 17

<212>PRT

<213> Homo sapiens

<400> 458

Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg

1 5 10 15

Ala

<210> 459

<211> 20

<212>PRT

<213> Homo sapiens

<400> 459

Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln

1 5 10 15

Tyr Tyr Glu Glu

20

<210> 460

<211> 22

<212>PRT

<213> Homo sapiens

<400> 460

Thr Ser Gly Val Thr Gln Ser Pro His Thr Leu Ile Lys Thr Arg Gly

1 5 10 15

Gln Gln Val Thr Leu Arg

20

<210> 461

<211> 15

<212>PRT

<213> Staphylococcus aureus

<400> 461

Val Leu Ala Arg Leu His Phe Tyr Arg Asn Asp Val His Lys Glu

1 5 10 15

<210> 462

<211> 5

<212>PRT

<213> Homo sapiens

<400> 462

Val Thr Leu Arg Ile

15

<210> 463

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 463

Tyr Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

Arg Thr Pro Pro

20

<210> 464

<211> 15

<212>PRT

<213> Influenza A virus

<400> 464

Tyr Arg Asn Leu Val Trp Phe Ile Lys Lys Asn Thr Arg Tyr Pro

1 5 10 15

<210> 465

<211> 20

<212>PRT

<213> Homo sapiens

<400> 465

Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr

1 5 10 15

Ala His Tyr Gly

20

<210> 466

<211> 20

<212>PRT

<213> Homo sapiens

<400> 466

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala

1 5 10 15

Gln Gly Thr Leu

20

<210> 467

<211> 23

<212>PRT

<213> Homo sapiens

<400> 467

Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg

1 5 10 15

His Arg Asp Thr Gly Ile Leu

20

<210> 468

<211> 45

<212>PRT

<213> Homo sapiens

<400> 468

Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser

1 5 10 15

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser

20 25 30

His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe

35 40 45

<210> 469

<211> 19

<212>PRT

<213> Homo sapiens

<400> 469

Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg

1 5 10 15

Thr Ala His

<210> 470

<211> 18

<212>PRT

<213> Homo sapiens

<400> 470

Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys

1 5 10 15

Gly Phe

<210> 471

<211> 15

<212>PRT

<213> Homo sapiens

<400> 471

His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys

1 5 10 15

<210> 472

<211> 20

<212>PRT

<213> Homo sapiens

<400> 472

Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser

1 5 10 15

Gly Lys Asp Ser

20

<210> 473

<211> 12

<212>PRT

<213> Cavia porcellus

<400> 473

Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly

1 5 10

<210> 474

<211> 20

<212>PRT

<213> Homo sapiens

<400> 474

Leu Cys Asn Met Tyr Lys Lys Asp Ser His His Pro Ala Arg Thr Ala

1 5 10 15

His Tyr Gly Ser

20

<210> 475

<211> 21

<212>PRT

<213> Homo sapiens

<400> 475

Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys

1 5 10 15

Arg Gly Ser Gly Lys

20

<210> 476

<211> 19

<212>PRT

<213> Homo sapiens

<400> 476

Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu Ala Gln

1 5 10 15

Leu Lys Ser

<210> 477

<211> 20

<212>PRT

<213> Homo sapiens

<400> 477

Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu Cys Asn Met Tyr Lys

1 5 10 15

Lys Asp Ser His

20

<210> 478

<211> 19

<212>PRT

<213> Homo sapiens

<400> 478

Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe

1 5 10 15

Gly Gly Asp

<210> 479

<211> 20

<212>PRT

<213> Homo sapiens

<400> 479

Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg

1 5 10 15

Pro Gly Phe Gly

20

<210> 480

<211> 20

<212>PRT

<213> Homo sapiens

<400> 480

Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys Pro

1 5 10 15

Gly Arg Ser Pro

20

<210> 481

<211> 20

<212>PRT

<213> Homo sapiens

<400> 481

Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val

1 5 10 15

Val His Phe Phe

20

<210> 482

<211> 20

<212>PRT

<213> Homo sapiens

<400> 482

Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr

1 5 10 15

Pro Arg Thr Pro

20

<210> 483

<211> 18

<212>PRT

<213> Homo sapiens

<400> 483

Thr Gln Asp Gln Asp Pro Asx Asx His Phe Phe Lys Asn Ile Val Thr

1 5 10 15

Pro Arg

<210> 484

<211> 20

<212>PRT

<213> Homo sapiens

<400> 484

Val Pro Trp Leu Lys Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg

1 5 10 15

Ser Gln Pro Gly

20

<210> 485

<211> 24

<212>PRT

<213> Homo sapiens

<400> 485

Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu

1 5 10 15

Ser Leu Ser Arg Phe Ser Trp Gly

20

<210> 486

<211> 19

<212>PRT

<213> Homo sapiens

<400> 486

Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr

1 5 10 15

Ala His Tyr

<210> 487

<211> 27

<212>PRT

<213> Homo sapiens

<400> 487

Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala

1 5 10 15

Thr Ala Ser Thr Met Asp His Ala Arg His Gly

20 25

<210> 488

<211> 13

<212>PRT

<213> Homo sapiens

<400> 488

Asp Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10

<210> 489

<211> 19

<212>PRT

<213> Homo sapiens

<400> 489

Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr

1 5 10 15

Lys Ser Ala

<210> 490

<211> 19

<212>PRT

<213> Homo sapiens

<400> 490

Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly

1 5 10 15

Lys Gly Arg

<210> 491

<211> 43

<212>PRT

<213> Homo sapiens

<400> 491

Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser

1 5 10 15

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser

20 25 30

His Gly Arg Thr Gln Asp Glu Asn Pro Val Val

35 40

<210> 492

<211> 12

<212>PRT

<213> Mus musculus

<400> 492

Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro

1 5 10

<210> 493

<211> 40

<212>PRT

<213> Homo sapiens

<400> 493

Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro

1 5 10 15

Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys

20 25 30

Gly Phe Lys Gly Val Asp Ala Gln

35 40

<210> 494

<211> 19

<212>PRT

<213> Homo sapiens

<400> 494

Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val

1 5 10 15

Asp Ala Gln

<210> 495

<211> 17

<212>PRT

<213> Homo sapiens

<400> 495

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser

1 5 10 15

His

<210> 496

<211> 19

<212>PRT

<213> Homo sapiens

<400> 496

Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser

1 5 10 15

Gly Lys Asp

<210> 497

<211> 19

<212>PRT

<213> Homo sapiens

<400> 497

Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe

1 5 10 15

Lys Leu Gly

<210> 498

<211> 24

<212>PRT

<213> Homo sapiens

<400> 498

Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly

1 5 10 15

Arg Gly Leu Ser Leu Ser Arg Phe

20

<210> 499

<211> 29

<212>PRT

<213> Homo sapiens

<400> 499

Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr Ala His

1 5 10 15

Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln

20 25

<210> 500

<211> 8

<212>PRT

<213> Homo sapiens

<400> 500

Leu Gly Arg Ala Gly Leu Thr Tyr

15

<210> 501

<211> 19

<212>PRT

<213> Homo sapiens

<400> 501

Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly

1 5 10 15

Phe Gly Tyr

<210> 502

<211> 18

<212>PRT

<213> Homo sapiens

<400> 502

Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His

1 5 10 15

Lys Gly

<210> 503

<211> 19

<212>PRT

<213> Homo sapiens

<400> 503

Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe

1 5 10 15

Ser Trp Gly

<210> 504

<211> 33

<212>PRT

<213> Oryctolagus cuniculus

<400> 504

Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Thr Val Leu Ser Arg Phe

1 5 10 15

Ser Trp Gly Ala Glu Gly Gln Lys Pro Gly Phe Gly Tyr Gly Gly Arg

20 25 30

Ala

<210> 505

<211> 17

<212>PRT

<213> Homo sapiens

<400> 505

Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

Arg

<210> 506

<211> 23

<212>PRT

<213> Homo sapiens

<400> 506

Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

Arg Thr Pro Pro Pro Ser Gln

20

<210> 507

<211> 27

<212>PRT

<213> Homo sapiens

<400> 507

Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp

1 5 10 15

Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu

20 25

<210> 508

<211> 26

<212>PRT

<213> Homo sapiens

<400> 508

Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys

1 5 10 15

Asp Ser His His Pro Ala Arg Thr Ala His

20 25

<210> 509

<211> 26

<212>PRT

<213> Homo sapiens

<400> 509

Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg

1 5 10 15

Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser

20 25

<210> 510

<211> 30

<212>PRT

<213> Homo sapiens

<400> 510

Arg His Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser

1 5 10 15

Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg

20 25 30

<210> 511

<211> 19

<212>PRT

<213> Homo sapiens

<400> 511

Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly

1 5 10 15

Gly Asp Arg

<210> 512

<211> 28

<212>PRT

<213> Homo sapiens

<400> 512

Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr

1 5 10 15

Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn

20 25

<210> 513

<211> 17

<212>PRT

<213> Homo sapiens

<400> 513

Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val

1 5 10 15

Val

<210> 514

<211> 15

<212>PRT

<213> Homo sapiens

<400> 514

Ser Ser Leu Gly Arg Ala Gly Leu Thr Tyr Glu Gln Tyr Phe Gly

1 5 10 15

<210> 515

<211> 31

<212>PRT

<213> Homo sapiens

<400> 515

Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg His

1 5 10 15

Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly

20 25 30

<210> 516

<211> 21

<212>PRT

<213> Homo sapiens

<400> 516

Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly

1 5 10 15

His Pro Asp Lys Phe

20

<210> 517

<211> 21

<212>PRT

<213> Homo sapiens

<400> 517

Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys

1 5 10 15

Gly Leu Ser Ala Thr

20

<210> 518

<211> 14

<212>PRT

<213> Homo sapiens

<400> 518

Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala

1 5 10

<210> 519

<211> 20

<212>PRT

<213> Homo sapiens

<400> 519

Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser

1 5 10 15

Leu Cys Ala Asp

20

<210> 520

<211> 21

<212>PRT

<213> Homo sapiens

<400> 520

Asp Gln Ala Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala

1 5 10 15

Ile Gly Glu Gly Lys

20

<210> 521

<211> 20

<212>PRT

<213> Homo sapiens

<400> 521

Glu Gly Lys Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu

1 5 10 15

Gly Gly Phe Thr

20

<210> 522

<211> 21

<212>PRT

<213> Homo sapiens

<400> 522

Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu

1 5 10 15

Val Leu Leu Ala Val

20

<210> 523

<211> 21

<212>PRT

<213> Homo sapiens

<400> 523

Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly

1 5 10 15

Met Glu Val Gly Trp

20

<210> 524

<211> 21

<212>PRT

<213> Homo sapiens

<400> 524

Glu Tyr Leu Ile Asn Val Ile His Ala Phe Gln Tyr Val Ile Tyr Gly

1 5 10 15

Thr Ala Ser Phe Phe

20

<210> 525

<211> 21

<212>PRT

<213> Homo sapiens

<400> 525

Phe Phe Gly Val Ala Leu Phe Cys Gly Cys Gly His Glu Ala Leu Thr

1 5 10 15

Gly Thr Glu Lys Leu

20

<210> 526

<211> 19

<212>PRT

<213> Homo sapiens

<400> 526

Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro

1 5 10 15

Trp Leu Lys

<210> 527

<211> 21

<212>PRT

<213> Homo sapiens

<400> 527

Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu

1 5 10 15

Gly Gly Arg Asp Ser

20

<210> 528

<211> 21

<212>PRT

<213> Homo sapiens

<400> 528

Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly

1 5 10 15

Arg Gly Thr Lys Phe

20

<210> 529

<211> 19

<212>PRT

<213> Homo sapiens

<400> 529

Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly

1 5 10 15

Asp Gln Ala

<210> 530

<211> 21

<212>PRT

<213> Homo sapiens

<400> 530

Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly

1 5 10 15

Arg Ala Ser Asp Tyr

20

<210> 531

<211> 20

<212>PRT

<213> Homo sapiens

<400> 531

Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg

1 5 10 15

Thr Ala His Tyr

20

<210> 532

<211> 21

<212>PRT

<213> Homo sapiens

<400> 532

Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu Thr

1 5 10 15

Tyr Phe Ser Lys Asn

20

<210> 533

<211> 21

<212>PRT

<213> Homo sapiens

<400> 533

Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly

1 5 10 15

Arg Phe Phe Gly Gly

20

<210> 534

<211> 21

<212>PRT

<213> Homo sapiens

<400> 534

Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala

1 5 10 15

Met Glu Leu Lys Val

20

<210> 535

<211> 21

<212>PRT

<213> Homo sapiens

<400> 535

Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys

1 5 10 15

Thr Thr Ile Cys Gly

20

<210> 536

<211> 21

<212>PRT

<213> Homo sapiens

<400> 536

Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala

1 5 10 15

Pro Lys Arg Gly Ser

20

<210> 537

<211> 21

<212>PRT

<213> Homo sapiens

<400> 537

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val

1 5 10 15

Gly Asp Glu Val Glu

20

<210> 538

<211> 21

<212>PRT

<213> Homo sapiens

<400> 538

Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser Leu Glu Arg Val

1 5 10 15

Cys His Cys Leu Gly

20

<210> 539

<211> 21

<212>PRT

<213> Homo sapiens

<400> 539

Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu Cys

1 5 10 15

Asn Met Tyr Lys Asp

20

<210> 540

<211> 20

<212>PRT

<213> Homo sapiens

<400> 540

Gly Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn

1 5 10 15

Leu Leu Ser Ile

20

<210> 541

<211> 21

<212>PRT

<213> Homo sapiens

<400> 541

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile

1 5 10 15

Thr Tyr Ala Leu Thr

20

<210> 542

<211> 20

<212>PRT

<213> Homo sapiens

<400> 542

His Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg

1 5 10 15

His Gly Phe Leu

20

<210> 543

<211> 12

<212>PRT

<213> Homo sapiens

<400> 543

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu

1 5 10

<210> 544

<211> 21

<212>PRT

<213> Homo sapiens

<400> 544

His Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg

1 5 10 15

Ile Ser Pro Gly Lys

20

<210> 545

<211> 21

<212>PRT

<213> Homo sapiens

<400> 545

Ile Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg Leu Arg Gly

1 5 10 15

Lys Leu Arg Ala Glu

20

<210> 546

<211> 21

<212>PRT

<213> Homo sapiens

<400> 546

Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly

1 5 10 15

Gln Arg Pro Gly Phe

20

<210> 547

<211> 21

<212>PRT

<213> Homo sapiens

<400> 547

Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly Gly

1 5 10 15

Gln Lys Gly Arg Gly

20

<210> 548

<211> 22

<212>PRT

<213> Homo sapiens

<400> 548

Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys

1 5 10 15

Arg Gly Ser Gly Lys Asp

20

<210> 549

<211> 21

<212>PRT

<213> Homo sapiens

<400> 549

Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu

1 5 10 15

His Arg Thr Phe Asp

20

<210> 550

<211> 21

<212>PRT

<213> Homo sapiens

<400> 550

Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser

1 5 10 15

Pro Met Ala Arg Arg

20

<210> 551

<211> 21

<212>PRT

<213> Homo sapiens

<400> 551

Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala

1 5 10 15

Val Arg Gln Ile Phe

20

<210> 552

<211> 21

<212>PRT

<213> Homo sapiens

<400> 552

Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser

1 5 10 15

Leu Pro Gln Lys Ser

20

<210> 553

<211> 21

<212>PRT

<213> Homo sapiens

<400> 553

Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His

1 5 10 15

Lys Gly Phe Lys Gly

20

<210> 554

<211> 21

<212>PRT

<213> Homo sapiens

<400> 554

Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro

1 5 10 15

Phe Ser Arg Val Val

20

<210> 555

<211> 16

<212>PRT

<213> Homo sapiens

<400> 555

Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr Ala

1 5 10 15

<210> 556

<211> 16

<212>PRT

<213> Homo sapiens

<400> 556

Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys Pro Gly Arg Ser

1 5 10 15

<210> 557

<211> 21

<212>PRT

<213> Homo sapiens

<400> 557

Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His

1 5 10 15

Phe Phe Lys Asn Ile

20

<210> 558

<211> 21

<212>PRT

<213> Homo sapiens

<400> 558

Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu

1 5 10 15

Ser Arg Phe Ser Trp

20

<210> 559

<211> 21

<212>PRT

<213> Homo sapiens

<400> 559

Arg Ala Glu Ile Glu Asn Leu His Arg Thr Phe Asp Pro His Phe Leu

1 5 10 15

Arg Val Pro Cys Trp

20

<210> 560

<211> 21

<212>PRT

<213> Homo sapiens

<400> 560

Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg

1 5 10 15

Asp His Ser Tyr Gln

20

<210> 561

<211> 21

<212>PRT

<213> Homo sapiens

<400> 561

Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln

1 5 10 15

Gly Thr Leu Ser Lys

20

<210> 562

<211> 21

<212>PRT

<213> Homo sapiens

<400> 562

Ser Gly Lys Val Pro Trp Leu Lys Pro Gly Arg Ser Pro Leu Pro Ser

1 5 10 15

His Ala Arg Ser Gln

20

<210> 563

<211> 11

<212>PRT

<213> Homo sapiens

<400> 563

Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly

1 5 10

<210> 564

<211> 21

<212>PRT

<213> Homo sapiens

<400> 564

Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro Trp Asn Ala

1 5 10 15

Phe Pro Gly Lys Val

20

<210> 565

<211> 20

<212>PRT

<213> Homo sapiens

<400> 565

Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu Asp Pro Phe

1 5 10 15

Tyr Trp Val Ser

20

<210> 566

<211> 21

<212>PRT

<213> Homo sapiens

<400> 566

Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg

1 5 10 15

Ile Arg Asn Val Arg

20

<210> 567

<211> 20

<212>PRT

<213> Homo sapiens

<400> 567

Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu

1 5 10 15

Phe Val Ile Val

20

<210> 568

<211> 21

<212>PRT

<213> Homo sapiens

<400> 568

Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln

1 5 10 15

Arg Pro Gly Phe Gly

20

<210> 569

<211> 21

<212>PRT

<213> Homo sapiens

<400> 569

Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly

1 5 10 15

Gln Phe Leu Glu Glu

20

<210> 570

<211> 21

<212>PRT

<213> Homo sapiens

<400> 570

Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp

1 5 10 15

Thr Thr Cys Gln Ser

20

<210> 571

<211> 21

<212>PRT

<213> Homo sapiens

<400> 571

Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr

1 5 10 15

Asn Trp Leu His Arg

20

<210> 572

<211> 21

<212>PRT

<213> Homo sapiens

<400> 572

Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val Ile

1 5 10 15

His Ala Phe Gln Tyr

20

<210> 573

<211> 21

<212>PRT

<213> Homo sapiens

<400> 573

Tyr Ile Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro

1 5 10 15

Ser Lys Thr Ser Ala

20

<210> 574

<211> 20

<212>PRT

<213> Homo sapiens

<400> 574

Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu

1 5 10 15

Arg Asn Pro Phe

20

<210> 575

<211> 21

<212>PRT

<213> Homo sapiens

<400> 575

Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg

1 5 10 15

Gly Arg Thr Glu Leu

20

<210> 576

<211> 32

<212>PRT

<213> Homo sapiens

<400> 576

Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe

1 5 10 15

Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg

20 25 30

<210> 577

<211> 14

<212>PRT

<213> Mus musculus

<400> 577

Ala Cys Ser Ala Val Thr Val Tyr Ile Tyr Phe Asn Thr Trp

1 5 10

<210> 578

<211> 19

<212>PRT

<213> Homo sapiens

<400> 578

Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala

1 5 10 15

Gln Gly Thr

<210> 579

<211> 20

<212>PRT

<213> Homo sapiens

<400> 579

Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys

1 5 10 15

Gly Leu Ser Ala

20

<210> 580

<211> 16

<212>PRT

<213> Mus musculus

<400> 580

Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr

1 5 10 15

<210> 581

<211> 31

<212>PRT

<213> Homo sapiens

<400> 581

Phe Gly Val Ala Leu Phe Cys Gly Cys Glu Val Glu Ala Leu Thr Gly

1 5 10 15

Thr Glu Lys Leu Ile Glu Thr Tyr Phe Ser Lys Asn Tyr Gln Asp

20 25 30

<210> 582

<211> 19

<212>PRT

<213> Homo sapiens

<400> 582

Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu

1 5 10 15

Gly Gly Arg

<210> 583

<211> 14

<212>PRT

<213> Mus musculus

<400> 583

Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val

1 5 10

<210> 584

<211> 19

<212>PRT

<213> Homo sapiens

<400> 584

Gly Leu Arg Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln

1 5 10 15

Gly Glu Val

<210> 585

<211> 40

<212>PRT

<213> Homo sapiens

<400> 585

Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His

1 5 10 15

Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly

20 25 30

Arg Phe Phe Gly Gly Asp Arg Gly

35 40

<210> 586

<211> 32

<212>PRT

<213> Homo sapiens

<400> 586

Gly Thr Ala Ser Phe Phe Phe Leu Tyr Gly Ala Leu Leu Leu Ala Tyr

1 5 10 15

Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp Tyr Lys

20 25 30

<210> 587

<211> 19

<212>PRT

<213> Homo sapiens

<400> 587

His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser

1 5 10 15

His Gly Arg

<210> 588

<211> 29

<212>PRT

<213> Homo sapiens

<400> 588

Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser

1 5 10 15

Gly Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr

20 25

<210> 589

<211> 32

<212>PRT

<213> Homo sapiens

<400> 589

Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser Leu Glu Arg

1 5 10 15

Val Cys His Cys Leu Gly Cys Trp Leu Gly His Pro Asp Lys Phe Val

20 25 30

<210> 590

<211> 32

<212>PRT

<213> Homo sapiens

<400> 590

Lys Val Cys Gly Ser Asn Leu Leu Ser Ile Cys Lys Thr Ala Glu Phe

1 5 10 15

Gln Met Thr Phe His Leu Phe Ile Ala Ala Phe Val Gly Ala Ala Ala

20 25 30

<210> 591

<211> 15

<212>PRT

<213> Mus musculus

<400> 591

Leu Phe Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser

1 5 10 15

<210> 592

<211> 32

<212>PRT

<213> Homo sapiens

<400> 592

Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr Val

1 5 10 15

Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr

20 25 30

<210> 593

<211> 31

<212>PRT

<213> Homo sapiens

<400> 593

Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe Ala Ser

1 5 10 15

Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe Cys

20 25 30

<210> 594

<211> 35

<212>PRT

<213> Mus musculus

<400> 594

Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser

1 5 10 15

Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala

20 25 30

Ala Phe Val

35

<210> 595

<211> 20

<212>PRT

<213> Homo sapiens

<400> 595

Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10 15

Arg Thr Pro Pro

20

<210> 596

<211> 31

<212>PRT

<213> Homo sapiens

<400> 596

Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Cys Gly Lys Gly Leu Ser

1 5 10 15

Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln

20 25 30

<210> 597

<211> 32

<212>PRT

<213> Homo sapiens

<400> 597

Ser Ala Ser Ile Gly Thr Leu Cys Ala Asp Ala Arg Met Tyr Gly Val

1 5 10 15

Leu Pro Trp Asn Ala Phe Phe Gly Lys Val Cys Gly Ser Asn Leu Leu

20 25 30

<210> 598

<211> 32

<212>PRT

<213> Homo sapiens

<400> 598

Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp Thr Thr Cys Gln

1 5 10 15

Ser Ile Ala Ala Pro Cys Lys Thr Ser Ala Ser Ile Gly Thr Leu Cys

20 25 30

<210> 599

<211> 15

<212>PRT

<213> Mus musculus

<400> 599

Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln His

1 5 10 15

<210> 600

<211> 32

<212>PRT

<213> Homo sapiens

<400> 600

Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val Ile

1 5 10 15

His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe Leu

20 25 30

<210> 601

<211> 12

<212>PRT

<213> Homo sapiens

<400> 601

Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10

<210> 602

<211> 9

<212>PRT

<213> Homo sapiens

<400> 602

Lys Val Glu Asp Pro Phe Tyr Trp Val

15

<210> 603

<211> 11

<212>PRT

<213> Homo sapiens

<400> 603

Pro Thr Arg Ala Pro Ser Gly Pro Arg Pro Pro

1 5 10

<210> 604

<211> 11

<212>PRT

<213> Homo sapiens

<400> 604

Arg Arg Arg Glu Gly Pro Asp Arg Ser Pro Arg

1 5 10

<210> 605

<211> 15

<212>PRT

<213> Human adenovirus

<400> 605

Asp Phe Glu Val Val Thr Phe Leu Lys Asp Val Leu Pro Glu Phe

1 5 10 15

<210> 606

<211> 15

<212>PRT

<213> Pseudomonas aeruginosa

<400> 606

Asp Arg Leu Leu Met Leu Phe Ala Lys Asp Val Val Ser Arg Asn

1 5 10 15

<210> 607

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 607

Glu Asn Pro Val Val His Tyr Phe Arg Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 608

<211> 15

<212>PRT

<213> Human herpes virus

<400> 608

Phe Arg Gln Leu Val His Phe Val Arg Asp Phe Ala Gln Leu Leu

1 5 10 15

<210> 609

<211> 13

<212>PRT

<213> Herpes simplex virus

<400> 609

Gly Gly Arg Arg Leu Phe Phe Val Lys Ala His Val Arg

1 5 10

<210> 610

<211> 15

<212>PRT

<213> Mammalian orthoreovirus

<400> 610

Met Ala Arg Ala Ala Phe Leu Phe Lys Thr Val Gly Phe Gly Gly

1 5 10 15

<210> 611

<211> 9

<212>PRT

<213> Homo sapiens

<400> 611

Lys Leu Ile Glu Thr Tyr Phe Ser Lys

15

<210> 612

<211> 9

<212>PRT

<213> Saccharomyces cerevisiae

<400> 612

Lys Leu Val Glu Thr Tyr Ile Ser Lys

15

<210> 613

<211> 21

<212>PRT

<213> Homo sapiens

<400> 613

Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe Tyr Ser Ile Gly Ile Asp

1 5 10 15

Gln Ile Ser Ser Glu

20

<210> 614

<211> 21

<212>PRT

<213> Homo sapiens

<400> 614

Ala Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Asn Tyr Glu Ala

1 5 10 15

Gln Pro Asp Lys Ser

20

<210> 615

<211> 21

<212>PRT

<213> Homo sapiens

<400> 615

Ala Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Asn Tyr Glu Ala

1 5 10 15

Gln Gln Asp Lys Ser

20

<210> 616

<211> 21

<212>PRT

<213> Homo sapiens

<400> 616

Ala Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu Ala

1 5 10 15

Gln Leu Asp Lys Ser

20

<210> 617

<211> 21

<212>PRT

<213> Homo sapiens

<400> 617

Asp Leu Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Val Gln

1 5 10 15

Asp Thr Asn Lys Gly

20

<210> 618

<211> 21

<212>PRT

<213> Homo sapiens

<400> 618

Asp Leu Gly Leu Gly Leu Arg Leu Ile His Tyr Ser Asn Thr Ala Gly

1 5 10 15

Thr Thr Gly Lys Gly

20

<210> 619

<211> 21

<212>PRT

<213> Homo sapiens

<400> 619

Asp Pro Gly Glu Gly Pro Val Leu Leu Ile Ala Leu Tyr Lys Ala Gly

1 5 10 15

Glu Leu Thr Ser Asn

20

<210> 620

<211> 21

<212>PRT

<213> Homo sapiens

<400> 620

Asp Pro Gly Lys Gly Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly

1 5 10 15

Glu Glu Lys Glu Lys

20

<210> 621

<211> 21

<212>PRT

<213> Homo sapiens

<400> 621

Asp Pro Gly Lys Ser Leu Glu Ser Leu Phe Val Leu Leu Ser Asn Gly

1 5 10 15

Ala Val Lys Gln Glu

20

<210> 622

<211> 21

<212>PRT

<213> Homo sapiens

<400> 622

Asp Pro Gly Met Glu Leu His Leu Ile His Tyr Ser Tyr Gly Val Asn

1 5 10 15

Ser Thr Glu Lys Gly

20

<210> 623

<211> 21

<212>PRT

<213> Homo sapiens

<400> 623

Asp Pro Gly Met Gly Leu Lys Leu Ile Tyr Tyr Ser Val Gly Ala Gly

1 5 10 15

Ile Thr Asp Lys Gly

20

<210> 624

<211> 21

<212>PRT

<213> Homo sapiens

<400> 624

Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly Ala Gly

1 5 10 15

Ile Thr Asp Gln Gly

20

<210> 625

<211> 21

<212>PRT

<213> Homo sapiens

<400> 625

Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly Glu Gly

1 5 10 15

Thr Thr Ala Lys Gly

20

<210> 626

<211> 21

<212>PRT

<213> Homo sapiens

<400> 626

Asp Pro Gly Met Gly Leu Arg Arg Ile His Tyr Ser Val Ala Ala Gly

1 5 10 15

Ile Thr Asp Lys Gly

20

<210> 627

<211> 21

<212>PRT

<213> Homo sapiens

<400> 627

Asp Pro Gly Arg Gly Pro Val Phe Leu Leu Leu Ile Arg Glu Asn Glu

1 5 10 15

Lys Glu Lys Arg Lys

20

<210> 628

<211> 21

<212>PRT

<213> Homo sapiens

<400> 628

Asp Ser Lys Lys Phe Leu Lys Ile Met Phe Ser Tyr Asn Asn Lys Glu

1 5 10 15

Leu Ile Ile Asn Glu

20

<210> 629

<211> 21

<212>PRT

<213> Homo sapiens

<400> 629

Asp Thr Gly Arg Gly Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu

1 5 10 15

Asn Thr Lys Ser Asn

20

<210> 630

<211> 20

<212>PRT

<213> Homo sapiens

<400> 630

Glu Lys Lys Ala Pro Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile

1 5 10 15

Glu Lys Lys Ser

20

<210> 631

<211> 21

<212>PRT

<213> Homo sapiens

<400> 631

Glu Leu Gly Lys Gly Pro Gln Leu Ile Ile Asp Ile Arg Ser Asn Val

1 5 10 15

Gly Glu Lys Lys Asp

20

<210> 632

<211> 21

<212>PRT

<213> Homo sapiens

<400> 632

Glu Leu Gly Lys Arg Pro Gln Leu Ile Ile Asp Ile Arg Ser Asn Val

1 5 10 15

Gly Glu Lys Lys Asp

20

<210> 633

<211> 21

<212>PRT

<213> Homo sapiens

<400> 633

Glu Pro Gly Ala Gly Leu Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met

1 5 10 15

Asp Met Lys Gln Asp

20

<210> 634

<211> 21

<212>PRT

<213> Homo sapiens

<400> 634

Glu Pro Gly Glu Gly Pro Val Leu Leu Val Thr Val Val Thr Gly Gly

1 5 10 15

Glu Val Lys Lys Leu

20

<210> 635

<211> 21

<212>PRT

<213> Homo sapiens

<400> 635

Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp Ile Arg Ser Asn Met

1 5 10 15

Asp Lys Arg Gln Gly

20

<210> 636

<211> 21

<212>PRT

<213> Homo sapiens

<400> 636

Glu Thr Ala Lys Thr Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly

1 5 10 15

Asp Glu Lys Lys Lys

20

<210> 637

<211> 18

<212>PRT

<213> Homo sapiens

<400> 637

Phe Pro Gly Cys Ala Pro Arg Leu Leu Val Lys Gly Ser Lys Pro Ser

1 5 10 15

Gln Gln

<210> 638

<211> 21

<212>PRT

<213> Homo sapiens

<400> 638

Phe Pro Gly Lys Gly Pro Ala Leu Leu Ile Ala Ile Arg Pro Asp Val

1 5 10 15

Ser Glu Lys Lys Glu

20

<210> 639

<211> 22

<212>PRT

<213> Homo sapiens

<400> 639

Phe Pro Lys Lys Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser

1 5 10 15

Lys Ala Thr Tyr Glu Gln

20

<210> 640

<211> 22

<212>PRT

<213> Homo sapiens

<400> 640

Phe Pro Lys Lys Ser Leu Met Gln Ile Ala Thr Ser Asn Glu Gly Ser

1 5 10 15

Lys Ala Thr Tyr Glu Gln

20

<210> 641

<211> 22

<212>PRT

<213> Homo sapiens

<400> 641

Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser

1 5 10 15

Lys Ala Thr Tyr Glu Gln

20

<210> 642

<211> 19

<212>PRT

<213> Homo sapiens

<400> 642

Phe Pro Ser Gln Gly Pro Arg Phe Ile Ile Gln Gly Tyr Lys Thr Lys

1 5 10 15

Val Thr Asn

<210> 643

<211> 21

<212>PRT

<213> Homo sapiens

<400> 643

Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu Lys Met

1 5 10 15

Gln Ser Asp Lys Gly

20

<210> 644

<211> 20

<212>PRT

<213> Homo sapiens

<400> 644

His Ala Gly Glu Ala Pro Thr Phe Leu Ser Tyr Asn Val Leu Asp Gly

1 5 10 15

Leu Glu Glu Lys

20

<210> 645

<211> 20

<212>PRT

<213> Homo sapiens

<400> 645

His Asp Gly Gly Ala Pro Thr Phe Leu Ser Tyr Asn Gly Leu Asp Gly

1 5 10 15

Leu Glu Glu Thr

20

<210> 646

<211> 19

<212>PRT

<213> Homo sapiens

<400> 646

His Pro Ala Gly Ala Ile Val Ser Leu Phe Met Leu Ser Ser Gln Lys

1 5 10 15

Lys Lys His

<210> 647

<211> 22

<212>PRT

<213> Homo sapiens

<400> 647

His Pro Asn Lys Gly Leu Gln Leu Leu Leu Lys Tyr Thr Ser Ala Ala

1 5 10 15

Thr Leu Val Lys Gly Ile

20

<210> 648

<211> 19

<212>PRT

<213> Homo sapiens

<400> 648

Ile His Ser Gln Gly Pro Gln Tyr Ile Ile His Gly Leu Lys Asn Asn

1 5 10 15

Glu Thr Asn

<210> 649

<211> 21

<212>PRT

<213> Homo sapiens

<400> 649

Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser Phe Tyr Asn Asn Glu

1 5 10 15

Ile Ser Glu Lys Ser

20

<210> 650

<211> 21

<212>PRT

<213> Homo sapiens

<400> 650

Lys Ala Lys Lys Pro Pro Glu Leu Met Phe Val Tyr Ser Tyr Glu Lys

1 5 10 15

Leu Ser Ile Asn Glu

20

<210> 651

<211> 21

<212>PRT

<213> Homo sapiens

<400> 651

Lys His Gly Glu Ala Pro Val Phe Leu Met Ile Leu Leu Lys Gly Gly

1 5 10 15

Glu Gln Lys Gly His

20

<210> 652

<211> 21

<212>PRT

<213> Homo sapiens

<400> 652

Lys His Gly Glu Ala Pro Val Phe Leu Met Ile Leu Leu Lys Gly Gly

1 5 10 15

Glu Gln Met Arg Arg

20

<210> 653

<211> 21

<212>PRT

<213> Homo sapiens

<400> 653

Lys Leu Glu Glu Glu Leu Lys Phe Leu Val Tyr Phe Gln Asn Glu Glu

1 5 10 15

Leu Ile Gln Lys Ala

20

<210> 654

<211> 21

<212>PRT

<213> Homo sapiens

<400> 654

Lys Ser Ser Gln Ala Pro Lys Leu Leu Phe His Tyr Tyr Asp Lys Asp

1 5 10 15

Phe Asn Asn Glu Ala

20

<210> 655

<211> 21

<212>PRT

<213> Homo sapiens

<400> 655

Lys Ser Ser Gln Ala Pro Lys Leu Leu Phe His Tyr Tyr Asn Lys Asp

1 5 10 15

Phe Asn Asn Glu Ala

20

<210> 656

<211> 21

<212>PRT

<213> Homo sapiens

<400> 656

Lys Tyr Gly Glu Gly Leu Ile Phe Leu Met Met Leu Gln Lys Gly Gly

1 5 10 15

Glu Glu Lys Ser His

20

<210> 657

<211> 19

<212>PRT

<213> Homo sapiens

<400> 657

Leu Pro Ser Gln Gly Pro Glu Tyr Val Ile His Gly Leu Thr Ser Asn

1 5 10 15

Val Asn Asn

<210> 658

<211> 19

<212>PRT

<213> Homo sapiens

<400> 658

Asn Pro Trp Gly Gln Leu Ile Asn Leu Phe Tyr Ile Pro Ser Gly Thr

1 5 10 15

Lys Gln Asn

<210> 659

<211> 21

<212>PRT

<213> Homo sapiens

<400> 659

Asn Gln Asn Lys Glu Phe Met Leu Leu Ile Ser Phe Gln Asn Glu Gln

1 5 10 15

Val Leu Gln Glu Thr

20

<210> 660

<211> 21

<212>PRT

<213> Homo sapiens

<400> 660

Asn Ser Gly Arg Gly Leu Val His Leu Ile Leu Ile Arg Ser Asn Glu

1 5 10 15

Arg Glu Lys His Ser

20

<210> 661

<211> 22

<212>PRT

<213> Homo sapiens

<400> 661

Pro Pro Ser Gly Glu Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp

1 5 10 15

Glu Gln Asn Glu Ile Ser

20

<210> 662

<211> 22

<212>PRT

<213> Homo sapiens

<400> 662

Pro Pro Ser Arg Gln Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys

1 5 10 15

Gln Gln Asn Ala Thr Glu

20

<210> 663

<211> 22

<212>PRT

<213> Homo sapiens

<400> 663

Pro Ser Ser Gly Glu Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp

1 5 10 15

Glu Gln Asn Ala Thr Glu

20

<210> 664

<211> 21

<212>PRT

<213> Homo sapiens

<400> 664

Arg Pro Gly Gly His Pro Val Phe Leu Ile Gln Leu Val Lys Ser Gly

1 5 10 15

Glu Val Lys Lys Gln

20

<210> 665

<211> 21

<212>PRT

<213> Homo sapiens

<400> 665

Ser Ala Lys Lys Pro Leu Glu Leu Met Phe Val Tyr Asn Phe Lys Glu

1 5 10 15

Gln Thr Glu Asn Asn

20

<210> 666

<211> 21

<212>PRT

<213> Homo sapiens

<400> 666

Ser Ala Lys Lys Pro Leu Glu Leu Met Phe Val Tyr Ser Leu Glu Glu

1 5 10 15

Arg Val Glu Asn Asn

20

<210> 667

<211> 21

<212>PRT

<213> Homo sapiens

<400> 667

Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile His Tyr Tyr Asn Gly Glu

1 5 10 15

Glu Arg Ala Lys Gly

20

<210> 668

<211> 21

<212>PRT

<213> Homo sapiens

<400> 668

Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln Tyr Tyr Asn Gly Glu

1 5 10 15

Glu Arg Ala Lys Gly

20

<210> 669

<211> 21

<212>PRT

<213> Homo sapiens

<400> 669

Thr Leu Glu Glu Glu Leu Lys Phe Phe Ile Tyr Phe Gln Asn Glu Glu

1 5 10 15

Ile Ile Gln Lys Ala

20

<210> 670

<211> 21

<212>PRT

<213> Homo sapiens

<400> 670

Thr Leu Gly Gln Gly Leu Gln Phe Leu Phe Glu Tyr Phe Ser Glu Thr

1 5 10 15

Gln Arg Asn Lys Gly

20

<210> 671

<211> 21

<212>PRT

<213> Homo sapiens

<400> 671

Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu Ala

1 5 10 15

Gln Leu Glu Lys Ser

20

<210> 672

<211> 16

<212>PRT

<213> Homo sapiens

<400> 672

Val Phe Leu Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu

1 5 10 15

<210> 673

<211> 21

<212>PRT

<213> Homo sapiens

<400> 673

Val Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr Glu Lys Glu

1 5 10 15

Glu Arg Gly Arg Gly

20

<210> 674

<211> 21

<212>PRT

<213> Homo sapiens

<400> 674

Val Leu Lys Asn Glu Phe Lys Phe Leu Val Ser Phe Gln Asn Glu Asn

1 5 10 15

Val Phe Asp Glu Thr

20

<210> 675

<211> 21

<212>PRT

<213> Homo sapiens

<400> 675

Val Met Gly Lys Glu Ile Lys Phe Leu Leu His Phe Val Lys Glu Ser

1 5 10 15

Lys Gln Asp Glu Ser

20

<210> 676

<211> 21

<212>PRT

<213> Homo sapiens

<400> 676

Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys

1 5 10 15

Asp Lys Asn Glu Asp

20

<210> 677

<211> 21

<212>PRT

<213> Homo sapiens

<400> 677

Tyr Pro Gly Glu Gly Leu Gln Leu Leu Leu Lys Ala Thr Lys Ala Asp

1 5 10 15

Asp Lys Gly Ser Asn

20

<210> 678

<211> 22

<212>PRT

<213> Homo sapiens

<400> 678

Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys Tyr Leu Ser Gly Ser

1 5 10 15

Thr Leu Val Glu Ser Ile

20

<210> 679

<211> 22

<212>PRT

<213> Homo sapiens

<400> 679

Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys Tyr Leu Ser Gly Ser

1 5 10 15

Thr Leu Val Lys Gly Ile

20

<210> 680

<211> 22

<212>PRT

<213> Homo sapiens

<400> 680

Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys Tyr Thr Ser Ala Ala

1 5 10 15

Thr Leu Val Lys Gly Ile

20

<210> 681

<211> 22

<212>PRT

<213> Homo sapiens

<400> 681

Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys Tyr Thr Ser Gly Ala

1 5 10 15

Thr Leu Val Lys Gly Ile

20

<210> 682

<211> 22

<212>PRT

<213> Homo sapiens

<400> 682

Tyr Pro Asn Gln Gly Leu Gln Leu Leu Leu Lys Tyr Thr Thr Gly Ala

1 5 10 15

Thr Leu Val Lys Gly Ile

20

<210> 683

<211> 22

<212>PRT

<213> Homo sapiens

<400> 683

Tyr Pro Asn Arg Gly Leu Gln Phe Leu Leu Lys Tyr Ile Thr Gly Asp

1 5 10 15

Asn Leu Val Lys Gly Ser

20

<210> 684

<211> 17

<212>PRT

<213> Homo sapiens

<400> 684

Tyr Pro Ser Lys Pro Leu Gln Leu Leu Gln Arg Glu Thr Met Glu Asn

1 5 10 15

Ser

<210> 685

<211> 20

<212>PRT

<213> Homo sapiens

<400> 685

Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly

1 5 10 15

Asp Lys Glu Asp

20

<210> 686

<211> 18

<212>PRT

<213> Homo sapiens

<400> 686

Tyr Ser Arg Gln Arg Leu Gln Leu Leu Leu Arg His Ile Ser Arg Glu

1 5 10 15

Ser Ile

<210> 687

<211> 8

<212>PRT

<213> Homo sapiens

<400> 687

Ala Asp Ala Arg Met Tyr Gly Val

15

<210> 688

<211> 20

<212>PRT

<213> Human herpes virus

<400> 688

Asp Pro Gly Glu Gly Pro Ser Thr Gly Pro Arg Gly Gln Gly Asp Gly

1 5 10 15

Gly Arg Arg Lys

20

<210> 689

<211> 20

<212>PRT

<213> Human herpes virus

<400> 689

Glu Ala Asp Tyr Phe Glu Tyr His Gln Glu Gly Gly Pro Asp Gly Glu

1 5 10 15

Pro Asp Val Pro

20

<210> 690

<211> 8

<212>PRT

<213> Homo sapiens

<400> 690

Glu Ala Leu Thr Gly Thr Glu Lys

15

<210> 691

<211> 20

<212>PRT

<213> Human herpes virus

<400> 691

Gly Cys Lys Gly Thr His Gly Gly Thr Gly Ala Gly Ala Gly Ala Gly

1 5 10 15

Gly Ala Gly Ala

20

<210> 692

<211> 31

<212>PRT

<213> Human herpes virus

<400> 692

Gly Glu Ala Asp Tyr Phe Glu Tyr His Gln Glu Gly Gly Pro Asp Gly

1 5 10 15

Glu Pro Asp Val Pro Pro Gly Ala Ile Glu Gln Gly Pro Ala Asp

20 25 30

<210> 693

<211> 20

<212>PRT

<213> Human herpes virus

<400> 693

Gly Gly Pro Asp Gly Glu Pro Asp Val Pro Pro Gly Ala Ile Glu Gln

1 5 10 15

Gly Pro Ala Asp

20

<210> 694

<211> 29

<212>PRT

<213> Human herpes virus

<400> 694

Gly Gly Pro Asp Gly Glu Pro Asp Val Pro Pro Gly Ala Ile Glu Gln

1 5 10 15

Gly Pro Ala Asp Asp Pro Gly Glu Gly Pro Ser Thr Gly

20 25

<210> 695

<211> 20

<212>PRT

<213> Human herpes virus

<400> 695

Gly Gly Arg Pro Gly Ala Pro Gly Gly Ser Gly Ser Gly Pro Arg His

1 5 10 15

Arg Asp Gly Val

20

<210> 696

<211> 20

<212>PRT

<213> Human herpes virus

<400> 696

Gly Asn Gly Leu Gly Glu Lys Gly Asp Thr Ser Gly Pro Glu Gly Ser

1 5 10 15

Gly Gly Ser Gly

20

<210> 697

<211> 20

<212>PRT

<213> Human herpes virus

<400> 697

Gly Arg Arg Pro Phe Phe His Pro Val Gly Glu Ala Asp Tyr Phe Glu

1 5 10 15

Tyr His Gln Glu

20

<210> 698

<211> 20

<212>PRT

<213> Human herpes virus

<400> 698

Gly Ser Gly Pro Arg His Arg Asp Gly Val Arg Arg Pro Gln Lys Arg

1 5 10 15

Pro Ser Cys Ile

20

<210> 699

<211> 30

<212>PRT

<213> Human herpes virus

<400> 699

Gly Ser Gly Pro Arg His Arg Asp Gly Val Arg Arg Pro Gln Lys Arg

1 5 10 15

Pro Ser Cys Ile Gly Cys Lys Gly Thr His Gly Gly Thr Gly

20 25 30

<210> 700

<211> 9

<212>PRT

<213> Homo sapiens

<400> 700

His Ala Arg His Gly Phe Leu Pro Arg

15

<210> 701

<211> 9

<212>PRT

<213> Homo sapiens

<400> 701

Ile Ile Cys Tyr Asn Trp Leu His Arg

15

<210> 702

<211> 9

<212>PRT

<213> Homo sapiens

<400> 702

Lys Leu Arg Ala Glu Ile Glu Asn Leu

15

<210> 703

<211> 9

<212>PRT

<213> Homo sapiens

<400> 703

Lys Gln Arg Ile Lys Ser Gln Glu Arg

15

<210> 704

<211> 10

<212>PRT

<213> Homo sapiens

<400> 704

Lys Arg Pro Ser Gln Arg His Gly Ser Lys

1 5 10

<210> 705

<211> 10

<212>PRT

<213> Homo sapiens

<400> 705

Leu Leu Ala Val Leu Pro Val Leu Leu Leu

1 5 10

<210> 706

<211> 9

<212>PRT

<213> Homo sapiens

<400> 706

Leu Leu Glu Cys Cys Ala Arg Cys Leu

15

<210> 707

<211> 9

<212>PRT

<213> Homo sapiens

<400> 707

Leu Gln Tyr Arg Leu Arg Gly Lys Leu

15

<210> 708

<211> 8

<212>PRT

<213> Homo sapiens

<400> 708

Leu Arg Ile Arg Asn Val Arg Phe

15

<210> 709

<211> 9

<212>PRT

<213> Homo sapiens

<400> 709

Leu Arg Lys Phe Ser Ser Leu Cys Tyr

15

<210> 710

<211> 20

<212>PRT

<213> Human herpes virus

<400> 710

Met Ser Asp Glu Gly Pro Gly Thr Gly Pro Gly Asn Gly Leu Gly Glu

1 5 10 15

Lys Gly Asp Thr

20

<210> 711

<211> 20

<212>PRT

<213> Human herpes virus

<400> 711

Pro Gly Ala Ile Glu Gln Gly Pro Ala Asp Asp Pro Gly Glu Gly Pro

1 5 10 15

Ser Thr Gly Pro

20

<210> 712

<211> 7

<212>PRT

<213> Human herpes virus

<400> 712

Pro Pro Pro Gly Arg Arg Pro

15

<210> 713

<211> 20

<212>PRT

<213> Human herpes virus

<400> 713

Pro Gln Arg Arg Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly

20

<210> 714

<211> 20

<212>PRT

<213> Human herpes virus

<400> 714

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Gly Arg Pro Gly Ala

1 5 10 15

Pro Gly Gly Ser

20

<210> 715

<211> 20

<212>PRT

<213> Human herpes virus

<400> 715

Arg Arg Pro Gln Lys Arg Pro Ser Cys Ile Gly Cys Lys Gly Thr His

1 5 10 15

Gly Gly Thr Gly

20

<210> 716

<211> 9

<212>PRT

<213> Homo sapiens

<400> 716

Arg Thr Glu Leu Leu Lys Asp Ala Ile

15

<210> 717

<211> 10

<212>PRT

<213> Homo sapiens

<400> 717

Arg Val Val His Leu Tyr Arg Asn Gly Lys

1 5 10

<210> 718

<211> 20

<212>PRT

<213> Human herpes virus

<400> 718

Ser Gly Pro Glu Gly Ser Gly Gly Ser Gly Pro Gln Arg Arg Gly Gly

1 5 10 15

Asp Asn His Gly

20

<210> 719

<211> 20

<212>PRT

<213> Human herpes virus

<400> 719

Ser Gly Ser Pro Pro Arg Arg Pro Pro Pro Gly Arg Arg Pro Phe Phe

1 5 10 15

His Pro Val Gly

20

<210> 720

<211> 9

<212>PRT

<213> Homo sapiens

<400> 720

Ser Leu Asp Val Met Ala Ser Gln Lys

15

<210> 721

<211> 36

<212>PRT

<213> Human herpes virus

<400> 721

Ser Ser Gln Ser Ser Ser Gly Ser Pro Pro Arg Arg Pro Pro Pro

1 5 10 15

Gly Arg Arg Pro Phe Phe His Pro Val Gly Glu Ala Asp Tyr Phe Glu

20 25 30

Tyr His Gln Glu

35

<210> 722

<211> 9

<212>PRT

<213> Homo sapiens

<400> 722

Thr Ala His Tyr Gly Ser Leu Pro Gln

15

<210> 723

<211> 20

<212>PRT

<213> Homo sapiens

<400> 723

Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly

1 5 10 15

Phe Gly Tyr Gly

20

<210> 724

<211> 19

<212>PRT

<213> Homo sapiens

<400> 724

Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu

1 5 10 15

Asp Lys Phe

<210> 725

<211> 15

<212>PRT

<213> Homo sapiens

<400> 725

Ala Ala Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His

1 5 10 15

<210> 726

<211> 13

<212>PRT

<213> Homo sapiens

<400> 726

Ala Glu Pro Pro Pro Pro Pro Glu Pro Ala Arg Ile

1 5 10

<210> 727

<211> 12

<212>PRT

<213> Homo sapiens

<400> 727

Ala Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe

1 5 10

<210> 728

<211> 11

<212>PRT

<213> Homo sapiens

<400> 728

Ala Leu Met Glu Gly Gly Glu Asn Gly Pro Trp

1 5 10

<210> 729

<211> 11

<212>PRT

<213> Homo sapiens

<400> 729

Ala Leu Met Leu Ala Ile Ser His Gly Arg Gln

1 5 10

<210> 730

<211> 9

<212>PRT

<213> Homo sapiens

<400> 730

Ala Leu Tyr Ser Gly Val His Lys Lys

15

<210> 731

<211> 15

<212>PRT

<213> Homo sapiens

<400> 731

Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln Ile Ser Ala Gly

1 5 10 15

<210> 732

<211> 12

<212>PRT

<213> Homo sapiens

<400> 732

Ala Arg Lys Leu Ile Gly Asp Pro Asn Leu Glu Phe

1 5 10

<210> 733

<211> 10

<212>PRT

<213> Homo sapiens

<400> 733

Ala Ser Ser Ser Val Leu Ser Ser Pro Ala

1 5 10

<210> 734

<211> 13

<212>PRT

<213> Homo sapiens

<400> 734

Ala Ser Val Asp Leu Lys Asn Thr Gly Arg Glu Glu Phe

1 5 10

<210> 735

<211> 14

<212>PRT

<213> Homo sapiens

<400> 735

Ala Ser Val Asp Leu Lys Asn Thr Gly Arg Glu Glu Phe Leu

1 5 10

<210> 736

<211> 16

<212>PRT

<213> Homo sapiens

<400> 736

Ala Ser Val Asp Leu Lys Asn Thr Gly Arg Glu Glu Phe Leu Thr Ala

1 5 10 15

<210> 737

<211> 10

<212>PRT

<213> Homo sapiens

<400> 737

Ala Thr Ala Leu Pro Thr Gly Thr Ser Lys

1 5 10

<210> 738

<211> 9

<212>PRT

<213> Homo sapiens

<400> 738

Ala Thr Ala Asn Gln Ile Ile Leu Lys

15

<210> 739

<211> 9

<212>PRT

<213> Homo sapiens

<400> 739

Ala Thr Ile Ile Asp Ile Leu Thr Lys

15

<210> 740

<211> 9

<212>PRT

<213> Homo sapiens

<400> 740

Ala Thr Val Ala Gly Val His Val Lys

15

<210> 741

<211> 12

<212>PRT

<213> Homo sapiens

<400> 741

Ala Thr Val Arg Gln Lys Leu Gln Asp Glu Thr Asn

1 5 10

<210> 742

<211> 9

<212>PRT

<213> Homo sapiens

<400> 742

Ala Thr Val Thr Pro Ser Pro Val Lys

15

<210> 743

<211> 9

<212>PRT

<213> Homo sapiens

<400> 743

Ala Val Ala Leu Pro Leu Gln Thr Lys

15

<210> 744

<211> 12

<212>PRT

<213> Homo sapiens

<400> 744

Ala Val Ile Leu Pro Pro Leu Ser Pro Tyr Phe Lys

1 5 10

<210> 745

<211> 9

<212>PRT

<213> Homo sapiens

<400> 745

Ala Val Gln Arg Thr Leu Leu Glu Lys

15

<210> 746

<211> 9

<212>PRT

<213> Homo sapiens

<400> 746

Ala Val Thr Asp Val Ile Ile Ala Lys

15

<210> 747

<211> 17

<212>PRT

<213> Homo sapiens

<400> 747

Ala Val Val Asp Lys Ala Ala Glu Ala Gly Gly Ala Glu Glu Gln Tyr

1 5 10 15

Gly

<210> 748

<211> 9

<212>PRT

<213> Homo sapiens

<400> 748

Ala Val Tyr Ser His Val Ile Gln Lys

15

<210> 749

<211> 12

<212>PRT

<213> Homo sapiens

<400> 749

Ala Trp Lys Arg Ala Glu Ala Ile Glu Ser Ser Leu

1 5 10

<210> 750

<211> 10

<212>PRT

<213> Homo sapiens

<400> 750

Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp

1 5 10

<210> 751

<211> 10

<212>PRT

<213> Homo sapiens

<400> 751

Asp Glu Ser Gly Pro Ser Ile Val His Arg

1 5 10

<210> 752

<211> 13

<212>PRT

<213> Homo sapiens

<400> 752

Asp Glu Trp Val Lys Pro Lys Asp Met Leu Gly Pro Lys

1 5 10

<210> 753

<211> 18

<212>PRT

<213> Homo sapiens

<400> 753

Asp Phe Ala Ile Val Lys Phe Thr Lys Val Leu Leu Gln Tyr Thr Gly

1 5 10 15

His Ile

<210> 754

<211> 14

<212>PRT

<213> Homo sapiens

<400> 754

Asp Gly Val Ile Lys Val Phe Asn Asp Met Lys Val Arg Lys

1 5 10

<210> 755

<211> 13

<212>PRT

<213> Homo sapiens

<400> 755

Asp Leu Pro Ser Glu Ala Ser Ala Ser Thr Ala Gly Pro

1 5 10

<210> 756

<211> 10

<212>PRT

<213> Homo sapiens

<400> 756

Asp Leu Pro Trp Phe Arg Thr Leu Ser Trp

1 5 10

<210> 757

<211> 13

<212>PRT

<213> Homo sapiens

<400> 757

Asp Leu Ser Gln Val Ala Ala Ile Ser Asn Asp Leu Lys

1 5 10

<210> 758

<211> 14

<212>PRT

<213> Homo sapiens

<400> 758

Asp Pro Pro Leu Ile Ala Leu Asp Lys Asp Ala Pro Leu Arg

1 5 10

<210> 759

<211> 9

<212>PRT

<213> Homo sapiens

<400> 759

Asp Thr Asp His Tyr Phe Leu Arg Tyr

15

<210> 760

<211> 11

<212>PRT

<213> Homo sapiens

<400> 760

Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe

1 5 10

<210> 761

<211> 14

<212>PRT

<213> Homo sapiens

<400> 761

Asp Val Ala Ser Val Gln Gln Gln Arg Gln Glu Gln Ser Tyr

1 5 10

<210> 762

<211> 15

<212>PRT

<213> Homo sapiens

<400> 762

Asp Val Gly Val Tyr Arg Ala Val Thr Pro Gln Gly Arg Pro Asp

1 5 10 15

<210> 763

<211> 10

<212>PRT

<213> Homo sapiens

<400> 763

Asp Val Ile Gly Asp Leu His Gln Cys Gln

1 5 10

<210> 764

<211> 9

<212>PRT

<213> Homo sapiens

<400> 764

Asp Val Ile Arg Leu Ile Met Gln Tyr

15

<210> 765

<211> 12

<212>PRT

<213> Homo sapiens

<400> 765

Glu Ile Ile Glu Glu Thr Lys Val Glu Asp Glu Lys

1 5 10

<210> 766

<211> 15

<212>PRT

<213> Homo sapiens

<400> 766

Glu Ile Ile Val Thr His Phe Pro Phe Asp Glu Gln Asn Cys Ser

1 5 10 15

<210> 767

<211> 10

<212>PRT

<213> Homo sapiens

<400> 767

Glu Leu Ile Asn Asn Glu Leu Ser His Phe

1 5 10

<210> 768

<211> 17

<212>PRT

<213> Homo sapiens

<400> 768

Glu Pro Gly Glu Pro Glu Phe Lys Tyr Ile Gly Asn Met His Gly Asn

1 5 10 15

Glu

<210> 769

<211> 15

<212>PRT

<213> Homo sapiens

<400> 769

Glu Pro Asn Ala Ile Val Ser Asp Gly Lys Tyr His Val Val Arg

1 5 10 15

<210> 770

<211> 10

<212>PRT

<213> Homo sapiens

<400> 770

Glu Arg Ile Ala Gly Leu Glu Gln Glu Asp

1 5 10

<210> 771

<211> 11

<212>PRT

<213> Homo sapiens

<400> 771

Glu Arg Thr Ala Lys Glu Leu Asp Thr Asn Thr

1 5 10

<210> 772

<211> 15

<212>PRT

<213> Homo sapiens

<400> 772

Glu Ser Asn Ala Ile Ile Asn Asp Gly Lys Tyr His Val Val Arg

1 5 10 15

<210> 773

<211> 11

<212>PRT

<213> Homo sapiens

<400> 773

Glu Thr Asp Leu Leu Asp Ile Arg Ser Glu Tyr

1 5 10

<210> 774

<211> 10

<212>PRT

<213> Homo sapiens

<400> 774

Glu Val Gly Gly Glu Ala Leu Gly Arg Leu

1 5 10

<210> 775

<211> 9

<212>PRT

<213> Homo sapiens

<400> 775

Phe Gly Glu Ser Leu Pro Ala Arg Phe

15

<210> 776

<211> 10

<212>PRT

<213> Homo sapiens

<400> 776

Phe Gly Tyr Ser Asn Arg Val Val Asp Leu

1 5 10

<210> 777

<211> 13

<212>PRT

<213> Homo sapiens

<400> 777

Phe Ile Thr Ala Asp His Leu Ile Glu Lys Leu Arg Thr

1 5 10

<210> 778

<211> 12

<212>PRT

<213> Homo sapiens

<400> 778

Phe Leu Gly Val Ala Tyr Gly Ala Thr Arg Tyr Asn

1 5 10

<210> 779

<211> 14

<212>PRT

<213> Homo sapiens

<400> 779

Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe

1 5 10

<210> 780

<211> 12

<212>PRT

<213> Homo sapiens

<400> 780

Phe Arg Asp Gly Asp Ile Leu Gly Lys Tyr Val Asp

1 5 10

<210> 781

<211> 11

<212>PRT

<213> Homo sapiens

<400> 781

Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu

1 5 10

<210> 782

<211> 10

<212>PRT

<213> Homo sapiens

<400> 782

Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu

1 5 10

<210> 783

<211> 12

<212>PRT

<213> Homo sapiens

<400> 783

Phe Arg Ile Asp Ser Val Ser Glu Gly Asn Ala Gly

1 5 10

<210> 784

<211> 13

<212>PRT

<213> Homo sapiens

<400> 784

Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg Ala

1 5 10

<210> 785

<211> 15

<212>PRT

<213> Homo sapiens

<400> 785

Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg Ala Val Phe

1 5 10 15

<210> 786

<211> 10

<212>PRT

<213> Homo sapiens

<400> 786

Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala

1 5 10

<210> 787

<211> 10

<212>PRT

<213> Homo sapiens

<400> 787

Phe Ser Val Ala Thr Val Gln Thr Thr Trp

1 5 10

<210> 788

<211> 12

<212>PRT

<213> Homo sapiens

<400> 788

Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys Phe

1 5 10

<210> 789

<211> 8

<212>PRT

<213> Homo sapiens

<400> 789

Phe Thr Arg Ser Leu Phe Val Asn

15

<210> 790

<211> 9

<212>PRT

<213> Homo sapiens

<400> 790

Phe Val Asn Asp Ile Phe Glu Arg Ile

15

<210> 791

<211> 8

<212>PRT

<213> Homo sapiens

<400> 791

Phe Val Gln Met Met Thr Ala Lys

15

<210> 792

<211> 14

<212>PRT

<213> Homo sapiens

<400> 792

Gly His Leu Tyr Arg Glu Asp Gln Thr Ser Pro Ala Pro Gly

1 5 10

<210> 793

<211> 16

<212>PRT

<213> Homo sapiens

<400> 793

Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu

1 5 10 15

<210> 794

<211> 17

<212>PRT

<213> Homo sapiens

<400> 794

Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu

1 5 10 15

Leu

<210> 795

<211> 14

<212>PRT

<213> Homo sapiens

<400> 795

Gly Asn Arg Ile Ala Gln Trp Gln Ser Phe Gln Leu Glu Gly

1 5 10

<210> 796

<211> 10

<212>PRT

<213> Homo sapiens

<400> 796

Gly Arg Thr Leu Gln Asn Thr Met Val Asn

1 5 10

<210> 797

<211> 12

<212>PRT

<213> Homo sapiens

<400> 797

Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp

1 5 10

<210> 798

<211> 9

<212>PRT

<213> Homo sapiens

<400> 798

Gly Thr Ala Asp Val His Phe Glu Arg

15

<210> 799

<211> 9

<212>PRT

<213> Homo sapiens

<400> 799

Gly Thr Phe Gly Gly Leu Gly Ser Lys

15

<210> 800

<211> 9

<212>PRT

<213> Homo sapiens

<400> 800

Gly Thr Ile Asn Ile Val His Pro Lys

15

<210> 801

<211> 10

<212>PRT

<213> Homo sapiens

<400> 801

Gly Val Ile Asp Val Ile Thr Lys Thr Trp

1 5 10

<210> 802

<211> 17

<212>PRT

<213> Homo sapiens

<400> 802

Gly Trp Ser Ser His Pro Pro Pro Ser Pro Cys Arg Glu Gln Glu Ile

1 5 10 15

Arg

<210> 803

<211> 15

<212>PRT

<213> Homo sapiens

<400> 803

His Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala

1 5 10 15

<210> 804

<211> 9

<212>PRT

<213> Homo sapiens

<400> 804

His Ile Ile Leu Val Leu Ser Gly Lys

15

<210> 805

<211> 9

<212>PRT

<213> Homo sapiens

<400> 805

His Ser Glu Arg His Val Leu Leu Tyr

15

<210> 806

<211> 9

<212>PRT

<213> Homo sapiens

<400> 806

Ile Phe Ala Asn Ala His Thr Tyr His

15

<210> 807

<211> 8

<212>PRT

<213> Homo sapiens

<400> 807

Ile Phe Glu Lys Ser Phe Val Asn

15

<210> 808

<211> 11

<212>PRT

<213> Homo sapiens

<400> 808

Ile Ile Glu Glu Thr Lys Val Glu Asp Glu Lys

1 5 10

<210> 809

<211> 9

<212>PRT

<213> Homo sapiens

<400> 809

Ile Ile Tyr Lys Gly Gly Thr Ser Arg

15

<210> 810

<211> 9

<212>PRT

<213> Homo sapiens

<400> 810

Ile Pro Met Gly Lys Ser Met Leu Val

15

<210> 811

<211> 10

<212>PRT

<213> Homo sapiens

<400> 811

Ile Pro Asn Lys Asn Arg Ala Glu Gln Leu

1 5 10

<210> 812

<211> 13

<212>PRT

<213> Homo sapiens

<400> 812

Ile Arg Glu Ala Asp Ile Asp Gly Asp Gly Gln Val Asn

1 5 10

<210> 813

<211> 12

<212>PRT

<213> Homo sapiens

<400> 813

Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser Val Ser

1 5 10

<210> 814

<211> 12

<212>PRT

<213> Homo sapiens

<400> 814

Ile Ser Lys Leu Ser Ala Lys Phe Gly Gly Gln Ala

1 5 10

<210> 815

<211> 16

<212>PRT

<213> Homo sapiens

<400> 815

Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg

1 5 10 15

<210> 816

<211> 17

<212>PRT

<213> Homo sapiens

<400> 816

Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg

1 5 10 15

Lys

<210> 817

<211> 17

<212>PRT

<213> Homo sapiens

<400> 817

Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser Asn Arg Val Val Asp

1 5 10 15

Leu

<210> 818

<211> 13

<212>PRT

<213> Homo sapiens

<400> 818

Ile Thr Ala Asn Ala Thr Glu Pro Gln Lys Ala Glu Asn

1 5 10

<210> 819

<211> 12

<212>PRT

<213> Homo sapiens

<400> 819

Ile Thr Gln Asn Gly Asp Tyr Gln Leu Arg Thr Gln

1 5 10

<210> 820

<211> 14

<212>PRT

<213> Homo sapiens

<400> 820

Ile Thr Ser Ile Val Lys Asp Ser Ser Ala Ala Arg Asn Gly

1 5 10

<210> 821

<211> 9

<212>PRT

<213> Homo sapiens

<400> 821

Ile Val Ala Gly Thr Leu Thr Asn Lys

15

<210> 822

<211> 16

<212>PRT

<213> Homo sapiens

<400> 822

Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly

1 5 10 15

<210> 823

<211> 18

<212>PRT

<213> Homo sapiens

<400> 823

Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly

1 5 10 15

Leu Ser

<210> 824

<211> 11

<212>PRT

<213> Homo sapiens

<400> 824

Ile Val Val Tyr Pro Val His Gly Phe Met Tyr

1 5 10

<210> 825

<211> 9

<212>PRT

<213> Homo sapiens

<400> 825

Lys Ile Ala Asp Arg Phe Leu Leu Tyr

15

<210> 826

<211> 15

<212>PRT

<213> Homo sapiens

<400> 826

Lys Ile Trp Arg Pro Asp Leu Val Leu Tyr Asn Asn Ala Asp Gly

1 5 10 15

<210> 827

<211> 10

<212>PRT

<213> Homo sapiens

<400> 827

Lys Pro Arg Asp Val Ser Ser Val Glu Leu

1 5 10

<210> 828

<211> 11

<212>PRT

<213> Homo sapiens

<400> 828

Lys Pro Thr Ile Ser Val Lys Glu Ala Phe Tyr

1 5 10

<210> 829

<211> 17

<212>PRT

<213> Homo sapiens

<400> 829

Lys Ser Ala Ile Glu Gly Ile Lys Tyr Ile Ala Glu Thr Met Lys Ser

1 5 10 15

Asp

<210> 830

<211> 9

<212>PRT

<213> Homo sapiens

<400> 830

Lys Thr Tyr Gly Glu Ile Phe Glu Lys

15

<210> 831

<211> 14

<212>PRT

<213> Homo sapiens

<400> 831

Lys Val Lys Lys Ile Tyr Leu Asp Glu Lys Arg Leu Leu Ala

1 5 10

<210> 832

<211> 15

<212>PRT

<213> Homo sapiens

<400> 832

Lys Val Lys Lys Ile Tyr Leu Asp Glu Lys Arg Leu Leu Ala Gly

1 5 10 15

<210> 833

<211> 16

<212>PRT

<213> Homo sapiens

<400> 833

Lys Val Lys Lys Ile Tyr Leu Asp Glu Lys Arg Leu Leu Ala Gly Asp

1 5 10 15

<210> 834

<211> 13

<212>PRT

<213> Homo sapiens

<400> 834

Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys

1 5 10

<210> 835

<211> 11

<212>PRT

<213> Homo sapiens

<400> 835

Lys Val Tyr Asn Glu Ala Gly Val Thr Phe Thr

1 5 10

<210> 836

<211> 12

<212>PRT

<213> Homo sapiens

<400> 836

Lys Tyr Leu Pro Gly Pro Leu Gln Asp Met Phe Lys

1 5 10

<210> 837

<211> 11

<212>PRT

<213> Homo sapiens

<400> 837

Leu Ala Ser Gly Val His Gly Leu Pro Leu Leu

1 5 10

<210> 838

<211> 12

<212>PRT

<213> Homo sapiens

<400> 838

Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr

1 5 10

<210> 839

<211> 13

<212>PRT

<213> Homo sapiens

<400> 839

Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala Ser

1 5 10

<210> 840

<211> 11

<212>PRT

<213> Homo sapiens

<400> 840

Leu Asp Thr His Pro Leu Pro Leu Val Glu Val

1 5 10

<210> 841

<211> 15

<212>PRT

<213> Homo sapiens

<400> 841

Leu Glu Arg Ile Gln Ile Gln Glu Ala Ala Lys Lys Lys Pro Gly

1 5 10 15

<210> 842

<211> 9

<212>PRT

<213> Homo sapiens

<400> 842

Leu Phe Ala Leu Thr Leu Pro Ile Trp

15

<210> 843

<211> 11

<212>PRT

<213> Homo sapiens

<400> 843

Leu Gly Ser Val Ala Gly Ile Phe Asn Tyr Tyr

1 5 10

<210> 844

<211> 10

<212>PRT

<213> Homo sapiens

<400> 844

Leu Gly Val Leu Glu Ser Asp Leu Pro Ser

1 5 10

<210> 845

<211> 12

<212>PRT

<213> Homo sapiens

<400> 845

Leu Ile Leu Pro Glu Ala Val Gly Gly Thr Val Phe

1 5 10

<210> 846

<211> 10

<212>PRT

<213> Homo sapiens

<400> 846

Leu Leu Pro Pro Pro Pro Pro Val Ala Arg

1 5 10

<210> 847

<211> 13

<212>PRT

<213> Homo sapiens

<400> 847

Leu Leu Val Ile Val Glu Leu Ile Pro Ser Thr Ser Ser

1 5 10

<210> 848

<211> 14

<212>PRT

<213> Homo sapiens

<400> 848

Leu Leu Val Pro Thr Lys Ala Arg Phe Pro Ala Phe Glu Leu

1 5 10

<210> 849

<211> 13

<212>PRT

<213> Homo sapiens

<400> 849

Leu Asn Glu Thr Gly Asp Glu Pro Phe Gln Tyr Lys Asn

1 5 10

<210> 850

<211> 14

<212>PRT

<213> Homo sapiens

<400> 850

Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys

1 5 10

<210> 851

<211> 11

<212>PRT

<213> Homo sapiens

<400> 851

Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr

1 5 10

<210> 852

<211> 14

<212>PRT

<213> Homo sapiens

<400> 852

Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln

1 5 10

<210> 853

<211> 13

<212>PRT

<213> Homo sapiens

<400> 853

Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe

1 5 10

<210> 854

<211> 9

<212>PRT

<213> Homo sapiens

<400> 854

Leu Thr Asp Arg Glu Leu Glu Glu Tyr

15

<210> 855

<211> 9

<212>PRT

<213> Homo sapiens

<400> 855

Leu Val Glu Ala Lys Gln Tyr Ile Ile

15

<210> 856

<211> 10

<212>PRT

<213> Homo sapiens

<400> 856

Leu Val Ser Ala Ser Gln Asp Gly Lys Leu

1 5 10

<210> 857

<211> 10

<212>PRT

<213> Homo sapiens

<400> 857

Leu Val Val Tyr Phe Phe Arg Val Arg Asn

1 5 10

<210> 858

<211> 10

<212>PRT

<213> Homo sapiens

<400> 858

Met Leu Ser Asn Pro Asp Leu Met Arg Gln

1 5 10

<210> 859

<211> 9

<212>PRT

<213> Homo sapiens

<400> 859

Met Pro Ile Leu Gly Leu Gly Thr Trp

15

<210> 860

<211> 15

<212>PRT

<213> Homo sapiens

<400> 860

Met Ser Ile Leu Gly Met Thr Pro Gly Phe Gly Asp Lys Thr Phe

1 5 10 15

<210> 861

<211> 10

<212>PRT

<213> Homo sapiens

<400> 861

Met Ser Leu Lys Gln Thr Pro Leu Ser Arg

1 5 10

<210> 862

<211> 10

<212>PRT

<213> Homo sapiens

<400> 862

Asn Glu Ile Glu Asp Thr Phe Arg Gln Phe

1 5 10

<210> 863

<211> 12

<212>PRT

<213> Homo sapiens

<400> 863

Asn Glu Thr Gly Asp Glu Pro Phe Gln Tyr Lys Asn

1 5 10

<210> 864

<211> 15

<212>PRT

<213> Homo sapiens

<400> 864

Asn Gln Glu Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly

1 5 10 15

<210> 865

<211> 10

<212>PRT

<213> Homo sapiens

<400> 865

Asn Arg Ile Thr Ile Pro Val Gln Thr Phe

1 5 10

<210> 866

<211> 8

<212>PRT

<213> Homo sapiens

<400> 866

Asn Thr Asp Ser Pro Leu Arg Tyr

15

<210> 867

<211> 9

<212>PRT

<213> Homo sapiens

<400> 867

Asn Thr Glu Glu Glu Gly Leu Lys Tyr

15

<210> 868

<211> 18

<212>PRT

<213> Homo sapiens

<400> 868

Asn Trp Val Arg Lys Val Phe Ile Asp Thr Ile Pro Asn Ile Met Phe

1 5 10 15

Phe Ser

<210> 869

<211> 11

<212>PRT

<213> Homo sapiens

<400> 869

Pro Glu Val Leu Asn Arg Ala Leu Ser Asn Leu

1 5 10

<210> 870

<211> 11

<212>PRT

<213> Homo sapiens

<400> 870

Pro Lys Phe Glu Val Ile Glu Lys Pro Gln Ala

1 5 10

<210> 871

<211> 15

<212>PRT

<213> Homo sapiens

<400> 871

Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly Pro Ala

1 5 10 15

<210> 872

<211> 11

<212>PRT

<213> Homo sapiens

<400> 872

Pro Ser Ile His Ile Trp Asp Thr Glu Thr Ile

1 5 10

<210> 873

<211> 13

<212>PRT

<213> Homo sapiens

<400> 873

Pro Val Asp Leu Ser Lys Trp Ser Gly Pro Leu Ser Leu

1 5 10

<210> 874

<211> 14

<212>PRT

<213> Homo sapiens

<400> 874

Gln Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe

1 5 10

<210> 875

<211> 11

<212>PRT

<213> Homo sapiens

<400> 875

Gln Ile Arg Glu Thr Ser Leu Asp Thr Lys Ser

1 5 10

<210> 876

<211> 9

<212>PRT

<213> Homo sapiens

<400> 876

Gln Leu Tyr Met Ile Gln Lys Lys Ser

15

<210> 877

<211> 9

<212>PRT

<213> Homo sapiens

<400> 877

Gln Leu Tyr Trp Ser His Pro Arg Lys

15

<210> 878

<211> 11

<212>PRT

<213> Homo sapiens

<400> 878

Gln Ser Met Asp Ser Lys Leu Ser Gly Arg Tyr

1 5 10

<210> 879

<211> 19

<212>PRT

<213> Homo sapiens

<400> 879

Gln Thr Pro Gln His Pro Ser Phe Leu Phe Gln Asp Lys Arg Val Ser

1 5 10 15

Trp Ser Leu

<210> 880

<211> 10

<212>PRT

<213> Homo sapiens

<400> 880

Gln Val Ala Asp Val Val Val Ser Arg Trp

1 5 10

<210> 881

<211> 10

<212>PRT

<213> Homo sapiens

<400> 881

Gln Val Leu Gly Val Val Ala Arg Ala Ala

1 5 10

<210> 882

<211> 9

<212>PRT

<213> Homo sapiens

<400> 882

Arg Ala Ile Glu Gln Leu Ala Met Met

15

<210> 883

<211> 10

<212>PRT

<213> Homo sapiens

<400> 883

Arg His Gly Ser Lys Tyr Leu Ala Thr Ala

1 5 10

<210> 884

<211> 18

<212>PRT

<213> Homo sapiens

<400> 884

Arg His Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala

1 5 10 15

Arg His

<210> 885

<211> 10

<212>PRT

<213> Homo sapiens

<400> 885

Arg Leu Tyr Pro Trp Gly Val Val Glu Val

1 5 10

<210> 886

<211> 10

<212>PRT

<213> Homo sapiens

<400> 886

Arg Gln Gln Pro Pro Asp Leu Val Glu Phe

1 5 10

<210> 887

<211> 11

<212>PRT

<213> Homo sapiens

<400> 887

Ser Cys Gly Asp Leu His Ser Val Met Leu Glu

1 5 10

<210> 888

<211> 15

<212>PRT

<213> Homo sapiens

<400> 888

Ser Glu His Glu Thr Arg Leu Val Ala Lys Leu Phe Lys Asp Tyr

1 5 10 15

<210> 889

<211> 11

<212>PRT

<213> Homo sapiens

<400> 889

Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp

1 5 10

<210> 890

<211> 14

<212>PRT

<213> Homo sapiens

<400> 890

Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe

1 5 10

<210> 891

<211> 10

<212>PRT

<213> Homo sapiens

<400> 891

Ser His Pro Pro Val Glu Gly Ser Tyr Ala

1 5 10

<210> 892

<211> 9

<212>PRT

<213> Homo sapiens

<400> 892

Ser Ile Phe Lys Gln Pro Val Thr Lys

15

<210> 893

<211> 9

<212>PRT

<213> Homo sapiens

<400> 893

Ser Ile Thr Ser Val Phe Ile Thr Lys

15

<210> 894

<211> 14

<212>PRT

<213> Homo sapiens

<400> 894

Ser Asn Ala Ile Ile Asn Asp Gly Lys Tyr His Val Val Arg

1 5 10

<210> 895

<211> 12

<212>PRT

<213> Homo sapiens

<400> 895

Ser Ser Lys Phe Gln Val Asp Asn Asn Asn Arg Leu

1 5 10

<210> 896

<211> 10

<212>PRT

<213> Homo sapiens

<400> 896

Ser Thr Asp Pro Ser Val Leu Gly Lys Tyr

1 5 10

<210> 897

<211> 9

<212>PRT

<213> Homo sapiens

<400> 897

Ser Thr Ile Glu Tyr Val Ile Gln Arg

15

<210> 898

<211> 11

<212>PRT

<213> Homo sapiens

<400> 898

Ser Thr Ile Gly Pro Glu Gly Val His Gln Lys

1 5 10

<210> 899

<211> 12

<212>PRT

<213> Homo sapiens

<400> 899

Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Ala

1 5 10

<210> 900

<211> 10

<212>PRT

<213> Homo sapiens

<400> 900

Ser Val Phe Gln Gln Gly Met Lys Asn Lys

1 5 10

<210> 901

<211> 11

<212>PRT

<213> Homo sapiens

<400> 901

Ser Val Pro Glu Phe Pro Leu Ser Pro Pro Lys

1 5 10

<210> 902

<211> 9

<212>PRT

<213> Homo sapiens

<400> 902

Ser Val Ser Pro Val Val His Val Arg

15

<210> 903

<211> 8

<212>PRT

<213> Homo sapiens

<400> 903

Thr Ala Ile Arg His His Val Leu

15

<210> 904

<211> 10

<212>PRT

<213> Homo sapiens

<400> 904

Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe

1 5 10

<210> 905

<211> 11

<212>PRT

<213> Homo sapiens

<400> 905

Thr Ile Ile Asp Leu Pro Gly Ile Thr Arg Val

1 5 10

<210> 906

<211> 10

<212>PRT

<213> Homo sapiens

<400> 906

Thr Ile Gln Lys Ser Ser Leu Asp Gln Leu

1 5 10

<210> 907

<211> 9

<212>PRT

<213> Homo sapiens

<400> 907

Thr Leu Leu Gly Asp Phe Ile Tyr Trp

15

<210> 908

<211> 10

<212>PRT

<213> Homo sapiens

<400> 908

Thr Met Asp His Ala Arg His Gly Phe Leu

1 5 10

<210> 909

<211> 16

<212>PRT

<213> Homo sapiens

<400> 909

Thr Asn Val Pro Arg Ala Ser Val Pro Asp Gly Phe Leu Ser Glu Leu

1 5 10 15

<210> 910

<211> 14

<212>PRT

<213> Homo sapiens

<400> 910

Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys

1 5 10

<210> 911

<211> 16

<212>PRT

<213> Homo sapiens

<400> 911

Thr Ser Pro Ala Lys Gln Gln Ala Pro Pro Val Arg Asn Leu His Gln

1 5 10 15

<210> 912

<211> 10

<212>PRT

<213> Homo sapiens

<400> 912

Thr Thr Gly Ile Leu Ser Ile Leu Phe Tyr

1 5 10

<210> 913

<211> 15

<212>PRT

<213> Homo sapiens

<400> 913

Thr Thr Met Glu Lys Ala Gly Ala His Leu Gln Gly Gly Ala Lys

1 5 10 15

<210> 914

<211> 9

<212>PRT

<213> Homo sapiens

<400> 914

Thr Thr Tyr Asn Tyr Ala Val Leu Lys

15

<210> 915

<211> 8

<212>PRT

<213> Homo sapiens

<400> 915

Thr Val Phe Ser Thr His Phe Met

15

<210> 916

<211> 12

<212>PRT

<213> Homo sapiens

<400> 916

Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg

1 5 10

<210> 917

<211> 13

<212>PRT

<213> Homo sapiens

<400> 917

Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu

1 5 10

<210> 918

<211> 12

<212>PRT

<213> Homo sapiens

<400> 918

Val Asp Trp Ile Ile Leu Gln Cys Ala Glu Asp Ile

1 5 10

<210> 919

<211> 12

<212>PRT

<213> Homo sapiens

<400> 919

Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu

1 5 10

<210> 920

<211> 10

<212>PRT

<213> Homo sapiens

<400> 920

Val Gly Gly Glu Ala Leu Gly Arg Leu Leu

1 5 10

<210> 921

<211> 13

<212>PRT

<213> Homo sapiens

<400> 921

Val His Leu Lys Asn Ala Ser Arg Gly Ser Ala Gly Asn

1 5 10

<210> 922

<211> 12

<212>PRT

<213> Homo sapiens

<400> 922

Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr

1 5 10

<210> 923

<211> 31

<212>PRT

<213> Homo sapiens

<400> 923

Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly

1 5 10 15

Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu

20 25 30

<210> 924

<211> 10

<212>PRT

<213> Homo sapiens

<400> 924

Val Ile Arg Leu Leu Leu Ala Ser Gly Ala

1 5 10

<210> 925

<211> 9

<212>PRT

<213> Homo sapiens

<400> 925

Val Leu Gly Asp Leu Phe Val Arg Asp

15

<210> 926

<211> 11

<212>PRT

<213> Homo sapiens

<400> 926

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys

1 5 10

<210> 927

<211> 25

<212>PRT

<213> Homo sapiens

<400> 927

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys

1 5 10 15

Val Gly Ala His Ala Gly Glu Tyr Gly

20 25

<210> 928

<211> 31

<212>PRT

<213> Homo sapiens

<400> 928

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys

1 5 10 15

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg

20 25 30

<210> 929

<211> 7

<212>PRT

<213> Homo sapiens

<400> 929

Val Gln Met Met Thr Ala Lys

15

<210> 930

<211> 15

<212>PRT

<213> Homo sapiens

<400> 930

Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly

1 5 10 15

<210> 931

<211> 10

<212>PRT

<213> Homo sapiens

<400> 931

Val Thr Ala Ser Lys Ala Ile Ile Glu Lys

1 5 10

<210> 932

<211> 9

<212>PRT

<213> Homo sapiens

<400> 932

Val Thr Met Thr Ala Ser Arg Met Leu

15

<210> 933

<211> 9

<212>PRT

<213> Homo sapiens

<400> 933

Val Thr Asn Pro Asp Thr Gly Arg Tyr

15

<210> 934

<211> 16

<212>PRT

<213> Homo sapiens

<400> 934

Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu

1 5 10 15

<210> 935

<211> 9

<212>PRT

<213> Homo sapiens

<400> 935

Val Thr Ser Pro Ile Arg Ala Ser Tyr

15

<210> 936

<211> 12

<212>PRT

<213> Homo sapiens

<400> 936

Val Thr Val Phe Pro Ile Gly Ile Gly Asp Arg Tyr

1 5 10

<210> 937

<211> 14

<212>PRT

<213> Homo sapiens

<400> 937

Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His

1 5 10

<210> 938

<211> 11

<212>PRT

<213> Homo sapiens

<400> 938

Val Val Ile Arg Gly Asn Ser Ile Ile Met Leu

1 5 10

<210> 939

<211> 11

<212>PRT

<213> Homo sapiens

<400> 939

Val Val Tyr Pro Ser Ser Ser Gln Glu Ser Glu

1 5 10

<210> 940

<211> 8

<212>PRT

<213> Homo sapiens

<400> 940

Val Tyr Arg Val Asn Ser Tyr Trp

15

<210> 941

<211> 17

<212>PRT

<213> Homo sapiens

<400> 941

Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His

1 5 10 15

Arg

<210> 942

<211> 18

<212>PRT

<213> Homo sapiens

<400> 942

Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His

1 5 10 15

Arg Lys

<210> 943

<211> 20

<212>PRT

<213> Homo sapiens

<400> 943

Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser Ile Val His

1 5 10 15

Arg Lys Cys Phe

20

<210> 944

<211> 10

<212>PRT

<213> Homo sapiens

<400> 944

Trp Ser Thr Val Leu Ser Thr Tyr His Phe

1 5 10

<210> 945

<211> 11

<212>PRT

<213> Homo sapiens

<400> 945

Trp Thr Thr Gly Thr Ile Ser Ser Gln Arg Phe

1 5 10

<210> 946

<211> 13

<212>PRT

<213> Homo sapiens

<400> 946

Trp Val Pro Tyr Ile Asn Gly Lys Phe Lys Lys Asp Asn

1 5 10

<210> 947

<211> 15

<212>PRT

<213> Homo sapiens

<400> 947

Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro

1 5 10 15

<210> 948

<211> 11

<212>PRT

<213> Homo sapiens

<400> 948

Tyr Ala Val Ala Val Val Lys Lys Asp Ser Gly

1 5 10

<210> 949

<211> 11

<212>PRT

<213> Homo sapiens

<400> 949

Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg

1 5 10

<210> 950

<211> 12

<212>PRT

<213> Homo sapiens

<400> 950

Tyr Asp Glu Ser Gly Pro Ser Ile Val His Arg Lys

1 5 10

<210> 951

<211> 14

<212>PRT

<213> Homo sapiens

<400> 951

Tyr Asp Asn Glu Phe Gly Tyr Ser Asn Arg Val Val Asp Leu

1 5 10

<210> 952

<211> 11

<212>PRT

<213> Homo sapiens

<400> 952

Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp

1 5 10

<210> 953

<211> 8

<212>PRT

<213> Homo sapiens

<400> 953

Tyr Glu Val Ser Gln Leu Lys Asp

15

<210> 954

<211> 8

<212>PRT

<213> Homo sapiens

<400> 954

Tyr Gly Met Pro Arg Gln Ile Leu

15

<210> 955

<211> 9

<212>PRT

<213> Homo sapiens

<400> 955

Tyr Ile Asp Glu Gln Phe Glu Arg Tyr

15

<210> 956

<211> 10

<212>PRT

<213> Homo sapiens

<400> 956

Tyr Ile Lys Glu Asp Glu Ala Leu Pro Ser

1 5 10

<210> 957

<211> 9

<212>PRT

<213> Homo sapiens

<400> 957

Tyr Leu Leu Leu Leu Leu Leu Leu Ser

15

<210> 958

<211> 13

<212>PRT

<213> Homo sapiens

<400> 958

Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala

1 5 10

<210> 959

<211> 17

<212>PRT

<213> Homo sapiens

<400> 959

Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr

1 5 10 15

His

<210> 960

<211> 10

<212>PRT

<213> Homo sapiens

<400> 960

Tyr Thr Asp Val Pro Phe His Asn Gln Tyr

1 5 10

<210> 961

<211> 11

<212>PRT

<213> Homo sapiens

<400> 961

Tyr Thr Glu Arg Asp Ala Ser Gly Met Leu Tyr

1 5 10

<210> 962

<211> 9

<212>PRT

<213> Homo sapiens

<400> 962

Ala Pro Ala His Ala Ile Thr Leu Thr

15

<210> 963

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 963

Ala Thr Leu Lys Pro Ala Thr Phe Leu

15

<210> 964

<211> 9

<212>PRT

<213> Human endogenous retrovirus W

<400> 964

Ala Thr Leu Asn Pro Ala Thr Phe Leu

15

<210> 965

<211> 9

<212>PRT

<213> Homo sapiens

<400> 965

Cys Pro Arg Gln Arg Ser Ser Arg Ala

15

<210> 966

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 966

Asp Pro Leu Asn Pro Thr Ser Gln Leu

15

<210> 967

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 967

Phe Pro Tyr Gln Arg Lys Tyr Pro Leu

15

<210> 968

<211> 9

<212>PRT

<213> Homo sapiens

<400> 968

Gly Pro Ala Arg Val Pro Val Pro Phe

15

<210> 969

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 969

Gly Pro Cys Phe Leu Trp Leu Lys Leu

15

<210> 970

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 970

Ile Pro Glu Glu Ala Glu Trp Phe Thr

15

<210> 971

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 971

Ile Pro Phe Leu Gly Ile Arg Glu Thr

15

<210> 972

<211> 9

<212>PRT

<213> Homo sapiens

<400> 972

Ile Pro Pro Lys Ala Lys Thr Pro Leu

15

<210> 973

<211> 9

<212>PRT

<213> Homo sapiens

<400> 973

Ile Pro Arg Leu Cys Pro Leu Gln Ala

15

<210> 974

<211> 12

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 974

Ile Pro Val Arg Pro Asp Ser Gln Phe Leu Phe Ala

1 5 10

<210> 975

<211> 12

<212>PRT

<213> Homo sapiens

<400> 975

Lys Glu Glu Asn Pro Thr Ala Phe Leu Asp Arg Leu

1 5 10

<210> 976

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 976

Lys Pro Asn Gly Gln Trp Arg Leu Val

15

<210> 977

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 977

Lys Pro Pro Pro Cys Pro Cys Pro Leu

15

<210> 978

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 978

Lys Val Ser Lys Pro Lys Ala Arg Leu

15

<210> 979

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 979

Leu Pro Leu Gly Ser Glu Gln Asn Leu

15

<210> 980

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 980

Leu Pro Thr Gly Gln Asp Phe Ser Leu

15

<210> 981

<211> 14

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 981

Met Pro Glu Ser Pro Thr Pro Leu Leu Gly Arg Asp Ile Leu

1 5 10

<210> 982

<211> 11

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 982

Met Pro Ser Pro Ser Glu Pro Arg Val Cys Leu

1 5 10

<210> 983

<211> 9

<212>PRT

<213> Homo sapiens

<400> 983

Asn Pro Asp Gly Tyr Ile Asp Val Leu

15

<210> 984

<211> 12

<212>PRT

<213> Human endogenous retrovirus W

<400> 984

Asn Pro His Thr Pro Gly Thr Ser Thr Gln Leu Ala

1 5 10

<210> 985

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 985

Asn Pro Arg Ser Glu Asn Thr Arg Leu

15

<210> 986

<211> 15

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 986

Pro Pro Pro Tyr Pro Ser Val Pro Ser Pro Thr Pro Ser Ser Thr

1 5 10 15

<210> 987

<211> 9

<212>PRT

<213> Homo sapiens

<400> 987

Gln Pro Leu Ser Cys Asp Trp Gly Thr

15

<210> 988

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 988

Arg Pro Ala Ala Asp Phe His Pro Phe

15

<210> 989

<211> 11

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 989

Arg Pro Leu Pro Leu Pro Ile Gly Leu Lys Ala

1 5 10

<210> 990

<211> 9

<212>PRT

<213> Homo sapiens

<400> 990

Ser Pro Asp Ser Ile Glu Gly Gln Leu

15

<210> 991

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 991

Ser Pro His Leu Phe Gly Gln Ala Leu

15

<210> 992

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 992

Thr Pro Ile Ala Arg Pro Leu Tyr Thr

15

<210> 993

<211> 9

<212>PRT

<213> Homo sapiens

<400> 993

Thr Pro Asn Glu Arg Ser Ala Ala Val

15

<210> 994

<211> 9

<212>PRT

<213> Homo sapiens

<400> 994

Val Pro Cys Leu Arg Lys Glu Leu Ile

15

<210> 995

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 995

Val Pro Pro Glu Ala Lys Met Pro Leu

15

<210> 996

<211> 9

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 996

Trp Pro His Cys Leu Trp Val Met Ala

15

<210> 997

<211> 11

<212>PRT

<213> Retrovirus associated with multiple sclerosis

<400> 997

Tyr Pro Ala Val Ser Ser Pro Tyr Thr Leu Leu

1 5 10

<210> 998

<211> 21

<212>PRT

<213> Human T-lymphotropic virus

<400> 998

Pro Pro Pro Pro Ser Ser Pro Thr His Asp Pro Pro Asp Ser Asp Pro

1 5 10 15

Gln Ile Pro Pro Pro

20

<210> 999

<211> 21

<212>PRT

<213> Homo sapiens

<400> 999

Pro Thr Arg Ala Pro Ser Gly Pro Arg Pro Pro Ser Arg Ser Gln Ala

1 5 10 15

Gln Thr Pro Pro Arg

20

<210> 1000

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1000

Ala Leu Thr Ile Tyr Glu Met Leu Gln Asn Ile Phe

1 5 10

<210> 1001

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1001

Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg

1 5 10

<210> 1002

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1002

Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu

1 5 10

<210> 1003

<211> 15

<212>PRT

<213> Helicobacter pylori

<400> 1003

Glu Glu Phe Ile Phe His Phe Ile Lys Asn Thr Arg Asp Gly Leu

1 5 10 15

<210> 1004

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1004

Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln

1 5 10

<210> 1005

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1005

Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr

1 5 10

<210> 1006

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1006

Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu

1 5 10

<210> 1007

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1007

Gly Arg Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn

1 5 10

<210> 1008

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1008

His Leu Lys Arg Tyr Tyr Gly Arg Ile Leu His Tyr

1 5 10

<210> 1009

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1009

His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala

1 5 10

<210> 1010

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1010

Lys Glu Tyr Ser His Cys Ala Trp Thr Ile Val Arg

1 5 10

<210> 1011

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1011

Leu Glu Lys Glu Asp Phe Thr Arg Gly Lys Leu Met

1 5 10

<210> 1012

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1012

Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln Cys

1 5 10

<210> 1013

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1013

Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly

1 5 10

<210> 1014

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1014

Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu Thr Gly

1 5 10

<210> 1015

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1015

Leu Trp Gln Leu Asn Gly Arg Leu Glu Tyr Cys Leu

1 5 10

<210> 1016

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1016

Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu

1 5 10

<210> 1017

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1017

Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser

1 5 10

<210> 1018

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1018

Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu

1 5 10

<210> 1019

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1019

Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn His

1 5 10

<210> 1020

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1020

Pro Glu Glu Ile Lys Gln Leu Gln Gln Phe Gln Lys

1 5 10

<210> 1021

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1021

Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg

1 5 10

<210> 1022

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1022

Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met

1 5 10

<210> 1023

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1023

Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu

1 5 10

<210> 1024

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1024

Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn Glu Thr

1 5 10

<210> 1025

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1025

Arg Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp

1 5 10

<210> 1026

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1026

Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu

1 5 10

<210> 1027

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1027

Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr

1 5 10

<210> 1028

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1028

Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile

1 5 10

<210> 1029

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1029

Val Tyr His Gln Ile Asn His Leu Lys Thr Val Leu

1 5 10

<210> 1030

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1030

Tyr Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn

1 5 10

<210> 1031

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1031

Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu

1 5 10

<210> 1032

<211> 3

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1032

Phe Phe Lys

1

<210> 1033

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1033

Leu Ile Met Phe Lys Asn Val Val Ile Lys

1 5 10

<210> 1034

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1034

Val Ile Ile Phe Phe Lys Asn Val Val Ile Lys

1 5 10

<210> 1035

<211> 11

<212>PRT

<213> Homo sapiens

<400> 1035

Val Val His Phe Phe Lys Asn Ile Val Thr Pro

1 5 10

<210> 1036

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1036

Val Val His Phe Phe Lys Asn Val Val Ile Lys

1 5 10

<210> 1037

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1037

Val Val His Phe Phe Lys Asn Val Val Ile Pro

1 5 10

<210> 1038

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1038

Val Val His Phe Phe Lys Asn Val Val Thr Pro

1 5 10

<210> 1039

<211> 3

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1039

Val Val Ile

1

<210> 1040

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1040

Val Val Ile Phe Phe Lys Asn Val Val Ile Lys

1 5 10

<210> 1041

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1041

Glu Arg Pro Asn His Thr Val

15

<210> 1042

<211> 5

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1042

Arg Pro Asn His Thr

15

<210> 1043

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1043

Thr Pro Arg Val Glu Arg Gly Asn His Thr Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1044

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1044

Thr Pro Arg Val Glu Arg Asn Gly His Ser Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1045

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1045

Thr Pro Arg Val Glu Arg Pro Asn His Thr Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1046

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1046

Ala Asp Asp Leu Lys Lys Leu Lys Pro Gly Leu Glu Lys Asp Phe Leu

1 5 10 15

Pro Leu Tyr

<210> 1047

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1047

Ala Val Gln Thr Gly Leu Asp Leu Leu Glu Ile Leu Arg Gln Glu Lys

1 5 10 15

Gly Gly Ser

<210> 1048

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1048

Asp Asn Leu Pro Arg Gly Ser Arg Ala His Ile Thr Leu Gly Cys Ala

1 5 10 15

Ala Asp Val

<210> 1049

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1049

Asp Gln Tyr Gln Tyr Gln Val Val Leu Val Glu Pro Lys Thr Ala Trp

1 5 10 15

Arg Leu Asp Cys Ala

20

<210> 1050

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1050

Asp Thr Val Ala Thr Leu Leu Glu Cys Lys Thr Leu Phe Ile Leu Arg

1 5 10 15

Gly Leu

<210> 1051

<211> 34

<212>PRT

<213> Homo sapiens

<400> 1051

Asp Val Leu Lys Lys Ser Tyr Ser Lys Ala Phe Thr Leu Thr Ile Ser

1 5 10 15

Ala Leu Phe Val Thr Pro Lys Thr Thr Gly Ala Arg Val Glu Leu Ser

20 25 30

Glu Gln

<210> 1052

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1052

Glu Glu Leu Gly Asn His Lys Ala Phe Lys Lys Glu Leu Arg Gln Phe

1 5 10 15

Val Pro Gly

<210> 1053

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1053

Glu Leu Gln Phe Pro Phe Leu Gln Asp Glu Asp Thr Val Ala Thr Leu

1 5 10 15

Leu Glu

<210> 1054

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1054

Glu Leu Ser Glu Gln Gln Leu Gln Leu Trp Pro Ser Asp Val Asp Lys

1 5 10 15

Leu Ser

<210> 1055

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1055

Glu Pro Arg Glu Lys Met Asp Leu Val Thr Tyr Phe Gly Lys Arg Pro

1 5 10 15

Pro Gly Val

<210> 1056

<211> 39

<212>PRT

<213> Homo sapiens

<400> 1056

Phe Pro Phe Leu Gln Asp Glu Asp Thr Val Ala Thr Leu Leu Glu Cys

1 5 10 15

Lys Thr Leu Phe Ile Leu Arg Gly Leu Pro Gly Ser Gly Lys Ser Thr

20 25 30

Leu Ala Arg Val Ile Val Asp

35

<210> 1057

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1057

Gly Ala Arg Gly Ala Phe Ser Glu Glu Tyr Lys Arg Leu Asp Glu Asp

1 5 10 15

Leu Ala Ala

<210> 1058

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1058

Gly Glu Glu Val Gly Glu Leu Ser Arg Gly Lys Leu Tyr Ser Leu Gly

1 5 10 15

Asn Gly Arg

<210> 1059

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1059

Gly Lys Pro Val Pro Thr Gln Gly Ser Arg Lys Gly Gly Ala Leu Gln

1 5 10 15

Ser Cys Thr Ile Ile

20

<210> 1060

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1060

Gly Trp Phe Leu Thr Lys Lys Ser Ser Glu Thr Leu Arg Lys Ala Gly

1 5 10 15

Gln Val Phe

<210> 1061

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1061

His Cys Thr Thr Lys Phe Cys Asp Tyr Gly Lys Ala Pro Gly Ala Glu

1 5 10 15

Glu Tyr Ala

<210> 1062

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1062

Ile Leu Arg Gln Glu Lys Gly Gly Ser Arg Gly Glu Glu Val Gly Glu

1 5 10 15

Leu Ser Arg

<210> 1063

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1063

Ile Thr Leu Gly Cys Ala Ala Asp Val Glu Ala Val Gln Thr Gly Leu

1 5 10 15

Asp Leu Leu

<210> 1064

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1064

Lys Ala Phe Thr Leu Thr Ile Ser Ala Leu Phe Val Thr Pro Lys Thr

1 5 10 15

Thr Gly Ala Arg

20

<210> 1065

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1065

Lys Ala Pro Gly Ala Glu Glu Tyr Ala Gln Gln Asp Val Leu Lys Lys

1 5 10 15

Ser Tyr Ser

<210> 1066

<211> 19

<212>PRT

<213> Mus musculus

<400> 1066

Lys Glu Lys Arg Gln Phe Val Pro Gly Asp Glu Pro Arg Glu Lys Met

1 5 10 15

Asp Leu Val

<210> 1067

<211> 32

<212>PRT

<213> Homo sapiens

<400> 1067

Lys Lys Leu Lys Pro Gly Leu Glu Lys Asp Phe Leu Pro Leu Tyr Phe

1 5 10 15

Gly Trp Phe Leu Thr Lys Lys Ser Ser Glu Thr Leu Arg Lys Ala Gly

20 25 30

<210> 1068

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1068

Lys Leu Tyr Ser Leu Gly Asn Gly Arg Trp Met Leu Thr Leu Ala Lys

1 5 10 15

Asn Met Glu

<210> 1069

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1069

Lys Arg Leu Asp Glu Asp Leu Ala Ala Tyr Cys Arg Arg Arg Asp Ile

1 5 10 15

Arg Ile Leu

<210> 1070

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1070

Lys Thr Ala Trp Arg Leu Asp Cys Ala Gln Leu Lys Glu Lys Asn Gln

1 5 10 15

Trp Gln Leu

<210> 1071

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1071

Leu Asp Asp Thr Asn His Glu Arg Glu Arg Leu Glu Gln Leu Phe Glu

1 5 10 15

Met Ala Asp

<210> 1072

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1072

Leu Glu Lys Asp Phe Leu Pro Leu Tyr Phe Gly Trp Phe Leu Thr Lys

1 5 10 15

Lys Ser Ser

<210> 1073

<211> 18

<212>PRT

<213> Mus musculus

<400> 1073

Leu Glu Gln Leu Phe Glu Met Ala Asp Gln Tyr Gln Gln Val Val Leu

1 5 10 15

Val Glu

<210> 1074

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1074

Leu Lys Glu Lys Asn Gln Trp Gln Leu Ser Ala Asp Asp Leu Lys Lys

1 5 10 15

Leu Lys

<210> 1075

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1075

Met Leu Thr Leu Ala Lys Asn Met Glu Val Arg Ala Ile Phe Thr Gly

1 5 10 15

Tyr Tyr Gly

<210> 1076

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1076

Met Ser Ser Ser Gly Ala Lys Asp Lys Pro Glu Leu Gln Phe Pro Phe

1 5 10 15

Leu Gln Asp

<210> 1077

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1077

Pro Ser Asp Val Asp Lys Leu Ser Pro Thr Asp Asn Leu Pro Arg Gly

1 5 10 15

Ser Arg Ala

<210> 1078

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1078

Gln Asp Val Leu Lys Lys Ser Tyr Ser Lys Ala Phe Thr Leu Thr Ile

1 5 10 15

Ser Ala Leu

<210> 1079

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1079

Arg Ala Ile Phe Thr Gly Tyr Tyr Gly Lys Gly Lys Pro Val Pro Thr

1 5 10 15

Gln Gly Ser

<210> 1080

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1080

Arg Arg Arg Asp Ile Arg Ile Leu Val Leu Asp Asp Thr Asn His Glu

1 5 10 15

Arg Glu

<210> 1081

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1081

Ser Gly Lys Ser Thr Leu Ala Arg Val Ile Val Asp Lys Tyr Arg Asp

1 5 10 15

Gly Thr Lys

<210> 1082

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1082

Thr Leu Phe Ile Leu Arg Gly Leu Pro Gly Ser Gly Lys Ser Thr Leu

1 5 10 15

Ala Arg Val

<210> 1083

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1083

Thr Leu Arg Lys Ala Gly Gln Val Phe Leu Glu Glu Leu Gly Asn His

1 5 10 15

Lys Ala Phe

<210> 1084

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1084

Val Asp Lys Tyr Arg Asp Gly Thr Lys Met Val Ser Ala Asp Ala Tyr

1 5 10 15

Lys Ile Thr

<210> 1085

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1085

Val Ser Ala Asp Ala Tyr Lys Ile Thr Pro Gly Ala Arg Gly Ala Phe

1 5 10 15

Ser Glu Glu

<210> 1086

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1086

Val Thr Pro Lys Thr Thr Gly Ala Arg Val Glu Leu Ser Glu Gln Gln

1 5 10 15

Leu Gln Leu

<210> 1087

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1087

Tyr Phe Gly Lys Arg Pro Pro Gly Val Leu His Cys Thr Thr Lys Phe

1 5 10 15

Cys Asp Tyr

<210> 1088

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1088

Ala Ala Met Glu Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro

1 5 10 15

<210> 1089

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1089

Cys Leu Gln Tyr Arg Leu Arg Gly Lys

15

<210> 1090

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1090

Cys Trp Lys Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu

1 5 10 15

<210> 1091

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1091

Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val

1 5 10 15

<210> 1092

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1092

Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe Val

1 5 10 15

<210> 1093

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1093

Glu Gly Gly Phe Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu

1 5 10 15

<210> 1094

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1094

Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu

1 5 10 15

<210> 1095

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1095

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro

<210> 1096

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1096

Phe Leu Cys Leu Gln Tyr Arg Leu Arg

15

<210> 1097

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1097

Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala

1 5 10 15

<210> 1098

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1098

Gly Glu Gly Lys Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp

1 5 10 15

<210> 1099

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1099

Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe

1 5 10 15

<210> 1100

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1100

Gly Leu Val Phe Leu Cys Leu Gln Tyr

15

<210> 1101

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1101

Gly Gln Phe Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val

1 5 10 15

<210> 1102

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1102

Gly Val Leu Val Leu Leu Ala Val Leu Pro Val Leu Leu Leu Gln Ile

1 5 10 15

<210> 1103

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1103

His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu

1 5 10 15

<210> 1104

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1104

His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys Ile

1 5 10 15

<210> 1105

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1105

Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu

1 5 10 15

<210> 1106

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1106

Ile Glu Asn Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro

1 5 10 15

<210> 1107

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1107

Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe

1 5 10 15

<210> 1108

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1108

Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr Asn

1 5 10 15

<210> 1109

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1109

Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg Ile Arg Asn Val

1 5 10 15

<210> 1110

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1110

Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser

1 5 10 15

Arg Val Val His Leu

20

<210> 1111

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1111

Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser

1 5 10 15

Arg Val Val His Leu

20

<210> 1112

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1112

Leu Cys Leu Gln Tyr Arg Leu Arg Gly

15

<210> 1113

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1113

Leu Gly Pro Leu Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg

1 5 10 15

<210> 1114

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1114

Leu Lys Val Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val

1 5 10 15

<210> 1115

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1115

Leu Leu Ala Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu

1 5 10 15

<210> 1116

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1116

Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg

1 5 10 15

<210> 1117

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1117

Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu Cys

1 5 10 15

<210> 1118

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1118

Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu

1 5 10 15

<210> 1119

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1119

Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr Phe Asp Pro His Phe

1 5 10 15

<210> 1120

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1120

Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn Leu His Arg Thr Phe

1 5 10 15

<210> 1121

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1121

Leu Arg Val Pro Cys Trp Lys Ile Thr Leu Phe Val Ile Val Pro Val

1 5 10 15

<210> 1122

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1122

Leu Val Phe Leu Cys Leu Gln Tyr Arg

15

<210> 1123

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1123

Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly Arg

1 5 10 15

<210> 1124

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1124

Gln Ala Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile

1 5 10 15

<210> 1125

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1125

Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly Arg Thr Glu Leu Leu

1 5 10 15

<210> 1126

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1126

Gln Tyr Arg Leu Arg Gly Lys Leu Arg

15

<210> 1127

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1127

Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser Pro

1 5 10 15

<210> 1128

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1128

Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu

1 5 10 15

<210> 1129

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1129

Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe Phe Arg Asp His Ser

1 5 10 15

<210> 1130

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1130

Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys

1 5 10 15

<210> 1131

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1131

Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met Glu Val Gly Trp Tyr

1 5 10 15

<210> 1132

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1132

Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg Asn Pro Phe

1 5 10

<210> 1133

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1133

Arg Leu Arg Gly Lys Leu Arg Ala Glu

15

<210> 1134

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1134

Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp

1 5 10 15

<210> 1135

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1135

Ser Arg Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp

1 5 10 15

<210> 1136

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1136

Thr Cys Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu

1 5 10 15

<210> 1137

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1137

Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu Arg

1 5 10 15

<210> 1138

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1138

Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val

1 5 10 15

<210> 1139

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1139

Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu Ile

1 5 10 15

<210> 1140

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1140

Thr Pro Arg Val Glu Arg Asn Gly His Ser Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1141

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1141

Thr Pro Arg Val Glu Arg Asn Gly His Ser Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1142

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1142

Thr Val Gly Leu Val Phe Leu Cys Leu Gln Tyr Arg Leu Arg Gly Lys

1 5 10 15

<210> 1143

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1143

Val Ala Leu Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly

1 5 10 15

<210> 1144

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1144

Val Phe Leu Cys Leu Gln Tyr Arg Leu

15

<210> 1145

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1145

Val Gly Leu Val Phe Leu Cys Leu Gln

15

<210> 1146

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1146

Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr Arg

1 5 10 15

<210> 1147

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1147

Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu Val

1 5 10 15

<210> 1148

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1148

Val Thr Leu Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe

1 5 10 15

<210> 1149

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1149

Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu Glu Glu Leu Arg Asn

1 5 10 15

<210> 1150

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1150

Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala Val Leu Pro Val Leu

1 5 10 15

<210> 1151

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1151

Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val Glu Asp Pro Phe Tyr

1 5 10 15

<210> 1152

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1152

Tyr Arg Gly Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys

1 5 10 15

<210> 1153

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1153

Tyr Arg Leu Arg Gly Lys Leu Arg Ala

15

<210> 1154

<211> 21

<212>PRT

<213> Human herpes virus

<400> 1154

Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala

1 5 10 15

Gly Gly Ala Gly Gly

20

<210> 1155

<211> 28

<212>PRT

<213> Human herpes virus

<400> 1155

Asp Gly Glu Pro Asp Val Pro Pro Gly Ala Ile Glu Gln Gly Pro Ala

1 5 10 15

Asp Asp Pro Gly Glu Gly Pro Ser Thr Gly Pro Arg

20 25

<210> 1156

<211> 22

<212>PRT

<213> Human herpes virus

<400> 1156

Gly Gly Ser Gly Gly Arg Arg Gly Arg Gly Arg Glu Arg Ala Arg Gly

1 5 10 15

Gly Ser Arg Glu Arg Ala

20

<210> 1157

<211> 26

<212>PRT

<213> Human herpes virus

<400> 1157

Gly Val Phe Val Tyr Gly Gly Ser Lys Thr Ser Leu Tyr Asn Leu Arg

1 5 10 15

Arg Gly Thr Ala Leu Ala Ile Pro Gln Cys

20 25

<210> 1158

<211> 26

<212>PRT

<213> Human herpes virus

<400> 1158

Lys Phe Glu Asn Ile Ala Glu Gly Leu Arg Ala Leu Leu Ala Arg Ser

1 5 10 15

His Val Glu Arg Thr Thr Asp Glu Gly Thr

20 25

<210> 1159

<211> 27

<212>PRT

<213> Human herpes virus

<400> 1159

Lys Lys Gly Gly Trp Phe Gly Lys His Arg Gly Gln Gly Gly Ser Asn

1 5 10 15

Pro Lys Phe Glu Asn Ile Ala Glu Gly Leu Arg

20 25

<210> 1160

<211> 44

<212>PRT

<213> Human herpes virus

<400> 1160

Met Ser Asp Glu Gly Pro Gly Thr Gly Pro Gly Asn Gly Leu Gly Glu

1 5 10 15

Lys Gly Asp Thr Ser Gly Pro Glu Gly Ser Gly Gly Ser Gly Pro Gln

20 25 30

Arg Arg Gly Gly Asp Asn His Gly Arg Gly Arg Gly

35 40

<210> 1161

<211> 27

<212>PRT

<213> Human herpes virus

<400> 1161

Pro Pro Arg Arg Pro Pro Pro Gly Arg Arg Pro Phe Phe His Pro Val

1 5 10 15

Gly Glu Ala Asp Tyr Phe Glu Tyr His Gln Glu

20 25

<210> 1162

<211> 28

<212>PRT

<213> Human herpes virus

<400> 1162

Pro Arg Gly Gln Gly Asp Gly Gly Arg Arg Lys Lys Gly Gly Trp Phe

1 5 10 15

Gly Lys His Arg Gly Gln Gly Gly Ser Asn Pro Lys

20 25

<210> 1163

<211> 26

<212>PRT

<213> Human herpes virus

<400> 1163

Gln Gly Pro Ala Asp Asp Pro Gly Glu Gly Pro Ser Thr Gly Pro Arg

1 5 10 15

Gly Gln Gly Asp Gly Gly Arg Arg Lys Lys

20 25

<210> 1164

<211> 20

<212>PRT

<213> Human herpes virus

<400> 1164

Arg Glu Arg Ala Arg Gly Gly Ser Arg Glu Arg Ala Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly

20

<210> 1165

<211> 149

<212>PRT

<213> Human herpes virus

<400> 1165

Arg Lys Lys Gly Gly Trp Phe Gly Lys His Arg Gly Gln Gly Gly Ser

1 5 10 15

Asn Pro Lys Phe Glu Asn Ile Ala Glu Gly Leu Arg Ala Leu Leu Ala

20 25 30

Arg Ser His Val Glu Arg Thr Thr Asp Glu Gly Thr Trp Val Ala Gly

35 40 45

Val Phe Val Tyr Gly Gly Ser Lys Thr Ser Leu Tyr Asn Leu Arg Arg

50 55 60

Gly Thr Ala Leu Ala Ile Pro Gln Cys Arg Leu Thr Pro Leu Ser Arg

65 70 75 80

Leu Pro Phe Gly Met Ala Pro Gly Pro Gly Pro Gln Pro Gly Pro Leu

85 90 95

Arg Glu Ser Ile Val Cys Tyr Phe Met Val Phe Leu Gln Thr His Ile

100 105 110

Phe Ala Glu Val Leu Lys Asp Ala Ile Lys Asp Leu Val Met Thr Lys

115 120 125

Pro Ala Pro Thr Cys Asn Ile Arg Val Thr Val Cys Ser Phe Asp Asp

130 135 140

Gly Val Asp Leu Pro

145

<210> 1166

<211> 28

<212>PRT

<213> Human herpes virus

<400> 1166

Val Glu Gly Ala Ala Ala Glu Gly Asp Asp Gly Asp Asp Gly Asp Glu

1 5 10 15

Gly Gly Asp Gly Asp Glu Gly Glu Glu Gly Gln Glu

20 25

<210> 1167

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1167

Ala Val Ile Met Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly

1 5 10 15

Pro Ile Ile Gly

20

<210> 1168

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1168

Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val

1 5 10 15

Glu Phe Lys Arg

20

<210> 1169

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1169

Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val Asp Arg

1 5 10 15

Gly Glu Glu Lys

20

<210> 1170

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1170

Glu Asp Asn Arg Ser Gln Val Glu Thr Asp Asp Leu Ile Leu Lys Pro

1 5 10 15

Gly Val Val His

20

<210> 1171

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1171

Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly Leu Gly

1 5 10 15

Val Thr Met Val

20

<210> 1172

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1172

Gly Lys Cys Gly Pro Leu Cys Thr Arg Glu Asn Ile Met Val Ala Phe

1 5 10 15

Lys Gly Val Trp

20

<210> 1173

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1173

Gly Thr Glu Lys Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys

1 5 10 15

Phe Gly Leu Ser

20

<210> 1174

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1174

His Gly Asn Leu Thr Ala Gly His Gly Leu Leu Val Glu Leu Ile Ile

1 5 10 15

Thr Phe Gln Leu

20

<210> 1175

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1175

His Leu Phe Ala Ile Asn Tyr Thr Gly Ala Ser Met Asn Pro Ala Arg

1 5 10 15

Ser Phe Gly Pro

20

<210> 1176

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1176

Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile

1 5 10 15

Asn Pro Ala Val

20

<210> 1177

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1177

Ile Ser Gly Gly His Ile Asn Pro Ala Val Thr Val Ala Met Val Cys

1 5 10 15

Thr Arg Lys Ile

20

<210> 1178

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1178

Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala Ile Gly Phe Ser

1 5 10 15

Val Ala Ile Gly

20

<210> 1179

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1179

Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys Pro Leu

1 5 10 15

Pro Val Asp Met

20

<210> 1180

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1180

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu

1 5 10 15

Cys Thr Arg Glu

20

<210> 1181

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1181

Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln Ala Phe Trp Lys

1 5 10 15

Ala Val Thr Ala

20

<210> 1182

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1182

Gln Gln Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln

1 5 10 15

Val Glu Thr Asp

20

<210> 1183

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1183

Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln Thr Lys Gly Ser

1 5 10 15

Tyr Met Glu Val

20

<210> 1184

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1184

Ser Ile Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala

1 5 10 15

Ile Ile Gly Ala

20

<210> 1185

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1185

Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met Gly Asn

1 5 10 15

Trp Glu Asn His

20

<210> 1186

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1186

Thr Gln Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu

1 5 10 15

Ile Phe Val Leu

20

<210> 1187

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1187

Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile Ala Lys Ser Val

1 5 10 15

Phe Tyr Ile Ala

20

<210> 1188

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1188

Val Phe Cys Pro Asp Val Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe

1 5 10 15

Ser Lys Ala Ala

20

<210> 1189

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1189

Val Phe Thr Ile Phe Ala Ser Cys Asp Ser Lys Arg Thr Asp Val Thr

1 5 10 15

Gly Ser Ile Ala

20

<210> 1190

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1190

Val Val Gly Gly Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala

1 5 10 15

Gly His Gly Leu

20

<210> 1191

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1191

Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly Ala Val Leu Ala Gly Gly

1 5 10 15

Leu Tyr Glu Tyr

20

<210> 1192

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1192

Asn Ala Thr Gly Met Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg

1 5 10 15

Val Val His

<210> 1193

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1193

Arg Ala Leu Val Gly Asp Glu Val Glu Leu Pro Cys

1 5 10

<210> 1194

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1194

Thr Pro Arg Val Glu Arg Phe Gly His Ser Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1195

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1195

Thr Pro Arg Val Glu Arg Gly Gly His Ser Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1196

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1196

Thr Pro Arg Val Glu Arg Gln Gly His Ser Val Phe Leu Ala Pro Tyr

1 5 10 15

Gly Trp Met Val Lys

20

<210> 1197

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1197

Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu Ser Ser Val

1 5 10 15

<210> 1198

<211> 24

<212>PRT

<213> Homo sapiens

<400> 1198

Phe Cys Pro Asp Val Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser

1 5 10 15

Lys Ala Ala Gln Gln Thr Lys Gly

20

<210> 1199

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1199

Asp Pro Gly Gln Leu Arg Leu Trp Arg Leu Ala Ser

1 5 10

<210> 1200

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1200

Phe His Gln Pro Thr Tyr Asp Tyr Thr Val Ser Arg

1 5 10

<210> 1201

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1201

Phe Ser Lys Thr Glu Pro Leu Ser Pro Ser Trp Phe

1 5 10

<210> 1202

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1202

Gly Thr Trp Ile Cys Asp Phe Lys Ser Cys Ser Trp

1 5 10

<210> 1203

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1203

His Ile Asp Val Ser Arg Pro Trp Arg Val Thr Gly

1 5 10

<210> 1204

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1204

His Trp Arg His Trp Leu Ala Asp Thr Ala Phe Pro

1 5 10

<210> 1205

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1205

His Tyr Asn Pro Trp Glu Gln Glu Pro Met Met Tyr

1 5 10

<210> 1206

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1206

Asn Ala Leu Thr Glu Ser Lys Tyr Val Lys Leu Leu

1 5 10

<210> 1207

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1207

Asn Cys Ala Phe Trp Leu Gly Lys Leu Tyr Cys Arg

1 5 10

<210> 1208

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1208

Asn Cys Ser Trp Cys His Val Leu Gln Arg Cys Ser

1 5 10

<210> 1209

<211> 10

<212>PRT

<213> Prochlorococcus marinus

<400> 1209

Asn Cys Trp Lys Pro Gln Val Leu His Cys

1 5 10

<210> 1210

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1210

Asn Asn Leu Thr Gln Ser Lys Phe Leu Arg Leu Gln

1 5 10

<210> 1211

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1211

Asn Asn Pro Ala Pro Val Tyr Thr His Arg Val Leu

1 5 10

<210> 1212

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1212

Asn Pro Val Glu His Trp Leu Ala Val Leu Pro Thr

1 5 10

<210> 1213

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1213

Asn Tyr Pro Ser Trp Leu His Ala Tyr Arg Leu Ala

1 5 10

<210> 1214

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1214

Gln His Asn Val Ser Arg Pro Trp Val Leu Phe Thr

1 5 10

<210> 1215

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1215

Ser Cys Asn Tyr His Gly Arg Thr Leu Thr Cys Trp

1 5 10

<210> 1216

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1216

Ser Cys Asn Tyr His His Thr Tyr Leu Thr Cys Trp

1 5 10

<210> 1217

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1217

Ser Cys Gln Leu Val Arg Thr Ile Trp Ser Cys Ser

1 5 10

<210> 1218

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1218

Ser Leu Gly Ser Lys Met Asp Ile Ser Arg Pro Trp

1 5 10

<210> 1219

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1219

Ser Thr Leu Ser Glu Ser Lys Val Asn Arg Leu Leu

1 5 10

<210> 1220

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1220

Thr Ala Gln Asp Ile Ser Arg Pro Trp Trp Phe Pro

1 5 10

<210> 1221

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1221

Thr Ile Met Asp Ile Ser Arg Thr Trp Thr Lys Val

1 5 10

<210> 1222

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1222

Thr Asn Thr Leu Thr Pro His Lys Leu Gln Met Leu

1 5 10

<210> 1223

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1223

Thr Pro Gln Gln Asp Leu Tyr Asp Ile Met Tyr Asp

1 5 10

<210> 1224

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1224

Thr Gln Gly Leu Lys Tyr Trp Tyr Pro Val Trp Ser

1 5 10

<210> 1225

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1225

Val Pro Gln Lys Tyr Trp Trp Leu Ser Asp His Thr

1 5 10

<210> 1226

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1226

Val Val Pro Lys Tyr Trp Trp Ser Ala Glu Leu Pro

1 5 10

<210> 1227

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1227

Trp His Trp Arg Gln Pro Thr Trp Leu Gln Val Ile

1 5 10

<210> 1228

<211> 11

<212>PRT

<213> Homo sapiens

<400> 1228

Phe Phe Arg Asp His Ser Tyr Gln Glu Glu Ala

1 5 10

<210> 1229

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1229

Phe Phe Arg Asp His Ser Tyr Gln Ser Glu Ala

1 5 10

<210> 1230

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1230

Ala Pro Ala His His Pro Pro

15

<210> 1231

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1231

Ala Pro Ala His Gln Ile Pro

15

<210> 1232

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1232

Ala Pro Pro His Leu Pro Pro

15

<210> 1233

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1233

Ala Pro Pro His Gln Met Pro

15

<210> 1234

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1234

Ala Pro Pro His Val Met Pro

15

<210> 1235

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1235

Ala Pro Ser His Pro Pro Pro

15

<210> 1236

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1236

Glu Phe Gly Thr Phe Leu Trp

15

<210> 1237

<211> 6

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1237

Phe Gly Thr Tyr Leu Trp

15

<210> 1238

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1238

Phe His Leu Pro Trp Met Gln

15

<210> 1239

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1239

Gly Pro Val Asn Met Asn Leu

15

<210> 1240

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1240

Gly Arg Gln Ala Gln Tyr Tyr

15

<210> 1241

<211> 11

<212>PRT

<213> Human herpes virus

<400> 1241

Gly Arg Arg Pro Phe Phe His Pro Val Gly Glu

1 5 10

<210> 1242

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1242

Ile Leu Asn Trp His Gln Phe

15

<210> 1243

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1243

Lys Phe Gly Thr Ala Leu Trp

15

<210> 1244

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1244

Lys Trp Pro Ile Ile Asp Thr

15

<210> 1245

<211> 6

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1245

Leu Asn Trp Asn Pro Phe

15

<210> 1246

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1246

Met Phe Asn Trp His Pro Phe

15

<210> 1247

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1247

Met Gln Ala His Gln Thr Lys

15

<210> 1248

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1248

Pro Leu Glu Leu Ser Val Tyr

15

<210> 1249

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1249

Pro Val Glu Leu Gln Leu Tyr

15

<210> 1250

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1250

Pro Val Gly Pro Trp Thr Asn

15

<210> 1251

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1251

Gln Phe Gly Thr Phe Leu Trp

15

<210> 1252

<211> 8

<212>PRT

<213> Homo sapiens

<400> 1252

Ser Phe Asp Gly Thr Phe Leu Trp

15

<210> 1253

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1253

Ser Phe Gly Thr Ala Leu Trp

15

<210> 1254

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1254

Ser Phe Gly Thr Phe Leu Trp

15

<210> 1255

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1255

Ser Phe Gly Thr Ile Leu Trp

15

<210> 1256

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1256

Ser His Arg Pro Thr Thr Gln

15

<210> 1257

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1257

Ser Gln Ser Val Ala Ala Ser

15

<210> 1258

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1258

Ser Thr Glu Gly Arg His Asn

15

<210> 1259

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1259

Thr Val Gln Pro Gln Phe His

15

<210> 1260

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1260

Thr Tyr Met Val Pro Ala Pro

15

<210> 1261

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1261

Val Leu Asn Arg Trp Asn Pro Phe

15

<210> 1262

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1262

Val Leu Asn Trp His Pro Phe

15

<210> 1263

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1263

Trp Gly Leu Asp Asn Pro Pro

15

<210> 1264

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1264

Trp Tyr Tyr Lys Pro Pro Ala

15

<210> 1265

<211> 9

<212>PRT

<213> Human herpes virus

<400> 1265

Arg Pro Arg Thr Pro Pro Pro Ser Tyr

15

<210> 1266

<211> 8

<212>PRT

<213> Homo sapiens

<400> 1266

Thr Pro Arg Thr Pro Pro Pro Gln

15

<210> 1267

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1267

Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly

1 5 10

<210> 1268

<211> 25

<212>PRT

<213> Homo sapiens

<400> 1268

Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser Leu Cys

1 5 10 15

Ala Asp Ala Arg Met Tyr Gly Val Leu

20 25

<210> 1269

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1269

Ser Leu Cys Phe Gly Leu Ser Ile Ala Thr Met Val Gln Cys Phe Gly

1 5 10 15

His

<210> 1270

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1270

Val Ile Asp Val Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser

1 5 10 15

Gly Glu

<210> 1271

<211> 11

<212>PRT

<213> Homo sapiens

<400> 1271

Gly Asp Glu Val Glu Leu Pro Cys Arg Ile Ser

1 5 10

<210> 1272

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1272

Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg Gln Tyr

1 5 10

<210> 1273

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1273

Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg Gln Tyr

1 5 10

<210> 1274

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1274

Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn

1 5 10

<210> 1275

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1275

Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn

1 5 10

<210> 1276

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1276

Gly Ile Thr Val Ser Arg Asn Gly Ser Ser Val Phe Thr Thr Ser Gln

1 5 10 15

Asp Ser Thr Leu Lys

20

<210> 1277

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1277

Thr Cys Phe Phe Arg Asp Gly Asn Tyr Gln Glu Glu Ala Ala Met Glu

1 5 10 15

Leu Lys Val Glu Asp

20

<210> 1278

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1278

Thr Phe Arg Asp Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn

1 5 10 15

Arg Ile Ser

<210> 1279

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with multiple sclerosis

<400> 1279

Thr Phe Arg Val Leu Arg Asn Gly Thr Ser Val Phe Leu His Pro Asn

1 5 10 15

Lys Trp Thr Val Lys

20

<210> 1280

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1280

Thr Leu Ile Asn Leu Thr Asn Leu Thr His Leu Tyr Leu His Asn Asn

1 5 10 15

Lys Phe Thr

<210> 1281

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1281

Val Val His Leu Tyr Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala

1 5 10 15

Pro Glu Tyr Arg Gly

20

<210> 1282

<211> 11

<212>PRT

<213> Homo sapiens

<400> 1282

Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg

1 5 10

<210> 1283

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1283

Lys Leu Thr Ser Glu Ala Arg Gly Arg Ile Pro Val Ala Gln Lys

1 5 10 15

<210> 1284

<211> 27

<212>PRT

<213> Homo sapiens

<400> 1284

Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu

1 5 10 15

Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu

20 25

<210> 1285

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1285

Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln

1 5 10 15

<210> 1286

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1286

Asp Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

<210> 1287

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1287

Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu

1 5 10 15

<210> 1288

<211> 7

<212>PRT

<213> Homo sapiens

<400> 1288

Gly Leu Gln Leu Tyr Phe Ser

15

<210> 1289

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1289

Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr

1 5 10 15

<210> 1290

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1290

Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly Asp Arg Gly Ala

1 5 10 15

<210> 1291

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1291

Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro Ala Arg Thr

1 5 10 15

<210> 1292

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1292

Tyr Leu Ala Ser Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu

1 5 10 15

Pro Arg Arg His Arg

20

<210> 1293

<211> 26

<212>PRT

<213> Zea mays

<400> 1293

Phe Thr Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Leu

1 5 10 15

Ala Thr Gly Asp Trp Thr Asn His Trp Val

20 25

<210> 1294

<211> 26

<212>PRT

<213> Homo sapiens

<400> 1294

Tyr Thr Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val

1 5 10 15

Ile Met Gly Asn Trp Glu Asn His Trp Ile

20 25

<210> 1295

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1295

Ala Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Ala Met Ala Pro Phe

1 5 10 15

Gly Ile Phe Gly

20

<210> 1296

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1296

Glu Leu Pro Tyr Pro Gln Pro Gln

15

<210> 1297

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1297

Phe Pro Gln Pro Glu Leu Pro Tyr

15

<210> 1298

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1298

Phe Pro Gln Pro Gln Pro Phe Pro Pro Gln

1 5 10

<210> 1299

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1299

Phe Pro Gln Pro Gln Gln Gln Phe Pro Gln

1 5 10

<210> 1300

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1300

Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro

1 5 10

<210> 1301

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1301

Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln

1 5 10

<210> 1302

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1302

Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro

1 5 10

<210> 1303

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1303

Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro

1 5 10

<210> 1304

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1304

Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro Gln Gln

1 5 10 15

<210> 1305

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1305

Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu

1 5 10

<210> 1306

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1306

Phe Ser Gln Pro Glu Gln Glu Phe Pro Gln Pro Gln

1 5 10

<210> 1307

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1307

Phe Ser Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln

1 5 10

<210> 1308

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1308

Gly Ile Ile Gln Pro Glu Gln Pro Ala Gln Leu

1 5 10

<210> 1309

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1309

Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu

1 5 10

<210> 1310

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1310

Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro Gln Ala Gln Gly Ser

1 5 10 15

<210> 1311

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1311

His Gln Pro Gln Gln Thr Phe Pro Gln Pro Gln Gln Thr Tyr Pro His

1 5 10 15

Gln Pro Gln Gln

20

<210> 1312

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1312

Ile His Ser Val Ala His Ser Ile Ile Met Gln Gln Glu Gln Gln Gln

1 5 10 15

Gly Val Pro Ile

20

<210> 1313

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1313

Ile Ile Gln Pro Glu Gln Pro Ala Gln Leu

1 5 10

<210> 1314

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1314

Ile Ile Gln Pro Gln Gln Pro Ala Gln

15

<210> 1315

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1315

Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu

1 5 10

<210> 1316

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1316

Leu Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu Glu Gly Ile Arg

1 5 10 15

Ser Leu Val Leu

20

<210> 1317

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1317

Leu Gly Gln Gly Ser Phe Arg Pro Ser Gln Gln Asn

1 5 10

<210> 1318

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1318

Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro Gln Pro

1 5 10 15

Gln

<210> 1319

<211> 19

<212>PRT

<213> Triticum aestivum

<400> 1319

Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro Gln Pro

1 5 10 15

Gln Pro Phe

<210> 1320

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1320

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Lys Pro Tyr Pro Gln Pro

1 5 10 15

Glu Lys Pro Tyr

20

<210> 1321

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1321

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Lys Pro Tyr Pro Gln Pro

1 5 10 15

Glu Leu Pro Tyr

20

<210> 1322

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1322

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Lys Pro Tyr Pro Gln Pro

1 5 10 15

Glu Leu Pro Tyr

20

<210> 1323

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1323

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro

1 5 10 15

Glu Lys Pro Tyr

20

<210> 1324

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1324

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro

1 5 10 15

Glu Leu Pro Tyr

20

<210> 1325

<211> 33

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1325

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro

1 5 10 15

Glu Leu Pro Tyr Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln Pro

20 25 30

Phe

<210> 1326

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1326

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1327

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1327

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1328

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1328

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Gln Leu Pro Tyr

20

<210> 1329

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1329

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Gln Leu Pro Tyr

20

<210> 1330

<211> 32

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1330

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Pro Phe

20 25 30

<210> 1331

<211> 33

<212>PRT

<213> Triticum aestivum

<400> 1331

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro

20 25 30

Phe

<210> 1332

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1332

Leu Gln Pro Phe Pro Gln Pro Glu

15

<210> 1333

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1333

Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr

1 5 10

<210> 1334

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1334

Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1335

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1335

Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro

1 5 10 15

Gln Gln Pro Gln

20

<210> 1336

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1336

Leu Arg Pro Leu Phe Gln Leu Ala Gln Gly Leu Gly Ile Ile Gln Pro

1 5 10 15

Gln Gln Pro Ala

20

<210> 1337

<211> 12

<212>PRT

<213> Human adenovirus 12

<400> 1337

Leu Arg Arg Gly Met Phe Arg Pro Ser Gln Cys Asn

1 5 10

<210> 1338

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1338

Pro Glu Leu Pro Tyr Pro Gln Pro

15

<210> 1339

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1339

Pro Glu Gln Pro Gln Gln Ser Phe Pro Glu Gln Glu Arg Pro

1 5 10

<210> 1340

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1340

Pro Phe Pro Gln Pro Glu Leu Pro

15

<210> 1341

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1341

Pro Phe Pro Gln Pro Gln Leu Pro Tyr

15

<210> 1342

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1342

Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro

1 5 10 15

<210> 1343

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1343

Pro Phe Pro Gln Pro Gln Gln Thr Phe Pro Gln Gln Pro Gln Leu Pro

1 5 10 15

Phe Pro Gln Gln

20

<210> 1344

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1344

Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10 15

Ser Phe Pro Gln

20

<210> 1345

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1345

Pro Phe Arg Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln

1 5 10

<210> 1346

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1346

Pro Phe Ser Gln Gln Gln Gln Gln

15

<210> 1347

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1347

Pro Phe Ser Gln Gln Gln Gln Ser Pro Phe

1 5 10

<210> 1348

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1348

Pro Phe Thr Gln Pro Gln Gln Pro Thr Pro Ile Gln Pro Gln Gln Pro

1 5 10 15

Phe Pro Gln Gln

20

<210> 1349

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1349

Pro Gln Pro Glu Leu Pro Tyr Pro

15

<210> 1350

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1350

Pro Gln Pro Glu Leu Pro Tyr Pro Gln

15

<210> 1351

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1351

Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Glu

1 5 10

<210> 1352

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1352

Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Glu Leu Pro Tyr

1 5 10

<210> 1353

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1353

Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1354

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1354

Pro Gln Pro Gln Leu Pro Tyr Pro Gln

15

<210> 1355

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1355

Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu

1 5 10

<210> 1356

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1356

Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1357

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1357

Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1358

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1358

Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1359

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1359

Pro Gln Pro Gln Gln Pro Gln Leu Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 1360

<211> 5

<212>PRT

<213> Triticum aestivum

<400> 1360

Pro Gln Gln Pro Phe

15

<210> 1361

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1361

Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Gln Gln Pro Phe Pro

1 5 10 15

Gln Ser Gln Gln

20

<210> 1362

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1362

Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln

1 5 10 15

Gln Pro Gln Gln

20

<210> 1363

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1363

Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10

<210> 1364

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1364

Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10

<210> 1365

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1365

Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln

1 5 10 15

Pro

<210> 1366

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1366

Pro Gln Gln Pro Phe Pro Gln Ser Gln Gln Pro Gln Gln Pro Phe Pro

1 5 10 15

Gln Pro Gln Gln

20

<210> 1367

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1367

Pro Gln Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Gln Gln Pro

20

<210> 1368

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1368

Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro

1 5 10

<210> 1369

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1369

Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro

1 5 10

<210> 1370

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1370

Pro Gln Gln Ser Phe Pro Glu Gln Glu

15

<210> 1371

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1371

Pro Gln Gln Ser Phe Pro Gln Gln Gln

15

<210> 1372

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1372

Pro Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1373

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1373

Pro Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro Gln

1 5 10 15

<210> 1374

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1374

Pro Tyr Pro Gln Pro Gln Leu Pro Tyr

15

<210> 1375

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1375

Pro Tyr Pro Gln Pro Gln Leu Pro Tyr

15

<210> 1376

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1376

Gln Ala Gln Gly Ser Val Gln Pro Gln Gln Leu Pro Gln Phe Glu

1 5 10 15

<210> 1377

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1377

Gln Phe Pro Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln

1 5 10 15

Gln Pro Ala Ile

20

<210> 1378

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1378

Gln Phe Pro Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10 15

Gln Thr Phe Pro

20

<210> 1379

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1379

Gln Phe Gln Gly Gln Gln Gln Pro Phe Pro

1 5 10

<210> 1380

<211> 15

<212>PRT

<213> Aegilops markgrafii

<400> 1380

Gln Gly Gln Gln Gly Tyr Tyr Pro Thr Ser Pro Gln Gln Ser Gly

1 5 10 15

<210> 1381

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1381

Gln Gly Gln Gln Gln Pro Phe Pro Pro Gln

1 5 10

<210> 1382

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1382

Gln Leu Ile Pro Cys Met Asp Val Val Leu

1 5 10

<210> 1383

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1383

Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln

1 5 10

<210> 1384

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1384

Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

<210> 1385

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1385

Gln Leu Gln Pro Phe Pro Gln Pro

15

<210> 1386

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1386

Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr

1 5 10

<210> 1387

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1387

Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Ser

<210> 1388

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1388

Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Ser

<210> 1389

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1389

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1390

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1390

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1391

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1391

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

<210> 1392

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1392

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Leu

<210> 1393

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1393

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Pro

<210> 1394

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1394

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Ser

<210> 1395

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1395

Gln Pro Glu Leu Pro Tyr Pro Gln

15

<210> 1396

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1396

Gln Pro Phe Pro Gln Pro Glu Leu

15

<210> 1397

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1397

Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr

1 5 10

<210> 1398

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1398

Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1399

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1399

Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu

1 5 10

<210> 1400

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1400

Gln Pro Gln Leu Pro Phe Pro Gln Gln Pro Gln Gln Pro

1 5 10

<210> 1401

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1401

Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln

1 5 10 15

<210> 1402

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1402

Gln Pro Gln Pro Phe Pro Pro Gln Leu Pro

1 5 10

<210> 1403

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1403

Gln Pro Gln Pro Phe Pro Gln Gln Ser Glu Gln Ser Gln Gln Pro Phe

1 5 10 15

Gln Pro Gln Pro Phe

20

<210> 1404

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1404

Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro

1 5 10

<210> 1405

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1405

Gln Pro Gln Pro Phe Arg Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro

1 5 10 15

Gln Tyr Ser Gln

20

<210> 1406

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1406

Gln Pro Gln Pro Gln Phe Pro Glu Gln Gln

1 5 10

<210> 1407

<211> 19

<212>PRT

<213> Triticum aestivum

<400> 1407

Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln

1 5 10 15

Gln Pro Gln

<210> 1408

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1408

Gln Pro Gln Gln Pro Ile Pro Val Gln Pro Gln Gln Ser

1 5 10

<210> 1409

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1409

Gln Pro Gln Gln Pro Ile Pro Val Gln Pro Gln Gln Ser Phe Pro Gln

1 5 10 15

Gln Ser Gln Gln

20

<210> 1410

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1410

Gln Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Gln Gln Gln Pro Leu

1 5 10 15

Ile Gln Pro Tyr

20

<210> 1411

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1411

Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro Phe

1 5 10 15

<210> 1412

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1412

Gln Pro Gln Gln Gln Tyr Pro Ser Gly Gln Gly Ser Phe Gln Pro Ser

1 5 10 15

Gln Gln Asn Pro

20

<210> 1413

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1413

Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln

1 5 10

<210> 1414

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1414

Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro

1 5 10

<210> 1415

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1415

Gln Pro Gln Gln Thr Phe Pro Glu Gln Ala

1 5 10

<210> 1416

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1416

Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr

1 5 10

<210> 1417

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1417

Gln Gln Phe Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10 15

Pro Tyr Pro Gln

20

<210> 1418

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1418

Gln Gln Gly Tyr Tyr Pro Thr Ser Pro Gln Gln Ser Gly

1 5 10

<210> 1419

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1419

Gln Gln Leu Pro Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln

1 5 10 15

Gln Arg Pro Phe

20

<210> 1420

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1420

Gln Gln Pro Phe Cys Gln Gln Pro Gln Arg Thr Ile Pro Gln Pro His

1 5 10 15

Gln Thr Phe His

20

<210> 1421

<211> 5

<212>PRT

<213> Triticum aestivum

<400> 1421

Gln Gln Pro Phe Pro

15

<210> 1422

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1422

Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10 15

Gln Pro Ile Pro

20

<210> 1423

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1423

Gln Gln Pro Leu Pro Gln Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln

1 5 10 15

Ser Gln Gln Pro

20

<210> 1424

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1424

Gln Gln Pro Pro Phe Ser Gln Gln Gln Gln Gln Pro Leu Pro Gln

1 5 10 15

<210> 1425

<211> 10

<212>PRT

<213> Triticum durum

<400> 1425

Gln Gln Pro Gln Asp Ala Val Gln Pro Phe

1 5 10

<210> 1426

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1426

Gln Gln Pro Gln Leu Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro

1 5 10 15

Gln Pro Gln Gln

20

<210> 1427

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1427

Gln Gln Pro Tyr Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr

1 5 10 15

Leu Gln Leu Gln

20

<210> 1428

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1428

Gln Gln Gln Phe Ile Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln

1 5 10 15

Gln Thr Tyr Pro

20

<210> 1429

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1429

Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro

1 5 10

<210> 1430

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1430

Gln Gln Gln Gln Pro Pro Phe Ser Gln Gln Gln Gln Ser Pro Phe Ser

1 5 10 15

Gln Gln Gln Gln

20

<210> 1431

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1431

Gln Gln Thr Tyr Pro His Gln Pro Gln Gln Gln Phe Pro Gln Thr Gln

1 5 10 15

Gln Pro Gln Gln

20

<210> 1432

<211> 21

<212>PRT

<213> Triticum aestivum

<220>

<221> misc_feature

<222> (3)..(3)

<223> Xaa can be any naturally occurring amino acid

<220>

<221> misc_feature

<222> (8)..(8)

<223> Xaa can be any naturally occurring amino acid

<220>

<221> misc_feature

<222> (14)..(14)

<223> Xaa can be any naturally occurring amino acid

<400> 1432

Gln Gln Xaa Ser Gln Pro Gln Xaa Pro Gln Gln Gln Gln Xaa Pro Gln

1 5 10 15

Gln Pro Gln Gln Phe

20

<210> 1433

<211> 19

<212>PRT

<213> Triticum aestivum

<400> 1433

Gln Gln Tyr Pro Leu Gly Gln Gly Ser Phe Arg Pro Ser Gln Gln Asn

1 5 10 15

Pro Gln Ala

<210> 1434

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1434

Gln Ser Glu Gln Ser Gln Gln Pro Phe Gln Pro Gln

1 5 10

<210> 1435

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1435

Gln Ser Phe Leu Gln Gln Gln Met Asn Pro Cys Lys Asn Phe Leu Leu

1 5 10 15

Gln Gln Cys Asn

20

<210> 1436

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1436

Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro

1 5 10 15

Phe Pro Gln Thr

20

<210> 1437

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1437

Gln Val Pro Leu Val Gln Gln Gln Gln Phe Leu Gly Gln Gln Gln Pro

1 5 10 15

Phe Pro Pro Gln

20

<210> 1438

<211> 9

<212>PRT

<213> Triticum aestivum

<220>

<221> misc_feature

<222> (2)..(2)

<223> Xaa can be any naturally occurring amino acid

<400> 1438

Gln Xaa Pro Gln Gln Pro Gln Gln Phe

15

<210> 1439

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1439

Ser Phe Pro Gln Gln Gln Gln Pro Ala Ile Gln Ser Phe Leu Gln Gln

1 5 10 15

Gln Met Asn Pro

20

<210> 1440

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1440

Ser Phe Gln Gln Pro Gln Gln Gln Tyr Pro

1 5 10

<210> 1441

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1441

Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn

1 5 10

<210> 1442

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1442

Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro Gln

1 5 10

<210> 1443

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1443

Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu

1 5 10 15

Pro Tyr Ser Gln

20

<210> 1444

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1444

Thr Ile Pro Gln Pro His Gln Thr Phe His His Gln Pro Gln Gln Thr

1 5 10 15

Phe Pro Gln Pro

20

<210> 1445

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1445

Thr Pro Ile Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro

1 5 10 15

Gln Gln Pro Phe

20

<210> 1446

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1446

Val Gln Gly Gln Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu

1 5 10 15

<210> 1447

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1447

Val Tyr Ile Pro Pro Tyr Cys Thr Ile Ala Pro Phe Gly Ile Phe Gly

1 5 10 15

Thr Asn Tyr Arg

20

<210> 1448

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1448

Trp Pro Gln Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Cys Gln

1 5 10 15

Gln Pro Gln Arg

20

<210> 1449

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1449

Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro

1 5 10 15

<210> 1450

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1450

Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro Phe Arg

1 5 10 15

<210> 1451

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1451

Tyr Pro Gln Pro Gln Pro Phe Pro Ser Gln

1 5 10

<210> 1452

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1452

Tyr Pro Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro

1 5 10 15

<210> 1453

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1453

Tyr Gln Gln Leu Pro Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln

1 5 10 15

Gln Gln Arg Pro Phe

20

<210> 1454

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1454

Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln

1 5 10

<210> 1455

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1455

Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu

1 5 10

<210> 1456

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1456

Ile Gln Pro Gln Gln Pro Ala Gln Leu

15

<210> 1457

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1457

Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro

1 5 10 15

<210> 1458

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1458

Gln Gln Pro Phe Pro Gln Gln Pro Gln

15

<210> 1459

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1459

Gln Gln Pro Gln Gln Pro Tyr Pro Gln

15

<210> 1460

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1460

Ser Gln Pro Gln Gln Gln Phe Pro Gln

15

<210> 1461

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1461

Phe Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro Gln

1 5 10 15

Pro Gln

<210> 1462

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1462

Phe Pro Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro Gln

1 5 10 15

Pro Gln Pro Phe

20

<210> 1463

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1463

Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro

1 5 10

<210> 1464

<211> 19

<212>PRT

<213> Triticum aestivum

<400> 1464

Gln Phe Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro

1 5 10 15

Gln Pro Gln

<210> 1465

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1465

Gln Asn Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln

1 5 10 15

Gln Gln

<210> 1466

<211> 19

<212>PRT

<213> Triticum aestivum

<400> 1466

Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn Pro Ser Gln Gln

1 5 10 15

Gln Pro Gln

<210> 1467

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1467

Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro

1 5 10 15

<210> 1468

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1468

Val Arg Val Pro Val Pro Gln Leu

15

<210> 1469

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1469

Leu Gln Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro

1 5 10 15

Glu Leu Pro Tyr

20

<210> 1470

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1470

Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr

1 5 10

<210> 1471

<211> 14

<212>PRT

<213> Avena sativa

<400> 1471

Gln Tyr Gln Pro Tyr Pro Glu Gln Gln Gln Pro Phe Val Gln

1 5 10

<210> 1472

<211> 19

<212>PRT

<213> Avena sativa

<400> 1472

Ser Glu Gln Tyr Gln Pro Tyr Pro Glu Gln Gln Glu Pro Phe Val Gln

1 5 10 15

Gln Gln Gln

<210> 1473

<211> 22

<212>PRT

<213> Avena nuda

<400> 1473

Thr Thr Thr Val Gln Tyr Asp Pro Ser Glu Gln Tyr Gln Pro Tyr Pro

1 5 10 15

Glu Gln Gln Glu Pro Phe

20

<210> 1474

<211> 22

<212>PRT

<213> Avena sativa

<400> 1474

Thr Thr Thr Val Gln Tyr Asn Pro Ser Glu Gln Tyr Gln Pro Tyr Pro

1 5 10 15

Glu Gln Gln Glu Pro Phe

20

<210> 1475

<211> 12

<212>PRT

<213> Avena sativa

<400> 1475

Tyr Gln Pro Tyr Pro Glu Gln Gln Glu Pro Phe Val

1 5 10

<210> 1476

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1476

Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Ser Gln Val Leu

1 5 10 15

Gln

<210> 1477

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1477

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln

1 5 10 15

<210> 1478

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1478

Ala Ala Glu Lys Gln Met Lys Asp Lys Gln

1 5 10

<210> 1479

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1479

Ala Glu Asp Lys Glu Asp Asp Ala Glu Asp

1 5 10

<210> 1480

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1480

Ala Lys Ile Asp Asp Pro Thr Asp Ser Lys

1 5 10

<210> 1481

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1481

Ala Ser Phe Ala Glu Ala Pro Phe Ser Asn

1 5 10

<210> 1482

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1482

Asp Ala Glu Asp Lys Asp Glu Asp Glu Glu

1 5 10

<210> 1483

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1483

Asp Glu Glu Asp Lys Glu Glu Asp Glu Glu

1 5 10

<210> 1484

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1484

Glu Asp Asp Ala Glu Asp Lys Asp Glu Asp

1 5 10

<210> 1485

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1485

Glu Asp Glu Glu Asp Glu Glu Asp Lys Glu

1 5 10

<210> 1486

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1486

Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu

1 5 10

<210> 1487

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1487

Glu Asp Lys Glu Glu Asp Glu Glu Glu Asp

1 5 10

<210> 1488

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1488

Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu

1 5 10

<210> 1489

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1489

Glu Glu Ala Glu Asp Lys Glu Asp Asp Ala

1 5 10

<210> 1490

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1490

Glu Glu Asp Glu Glu Asp Lys Glu Glu Asp

1 5 10

<210> 1491

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1491

Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu

1 5 10

<210> 1492

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1492

Glu Glu Glu Glu Ala Glu Asp Lys Glu Asp

1 5 10

<210> 1493

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1493

Glu Lys Asp Lys Gly Leu Gln Thr Ser Gln

1 5 10

<210> 1494

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1494

Glu Lys Gln Met Lys Asp Lys Gln Asp Glu

1 5 10

<210> 1495

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1495

Glu Gln Arg Leu Lys Glu Glu Glu Glu Asp

1 5 10

<210> 1496

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1496

Phe Ala Glu Ala Pro Phe Ser Asn Lys Gly

1 5 10

<210> 1497

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1497

Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe

1 5 10

<210> 1498

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1498

Gly Val Thr Lys Ala Ala Glu Lys Gln Met

1 5 10

<210> 1499

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1499

Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp

1 5 10

<210> 1500

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1500

Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp

1 5 10

<210> 1501

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1501

Lys Glu Glu Glu Glu Asp Lys Lys Arg Lys

1 5 10

<210> 1502

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1502

Lys Gly Lys Asn Val Leu Ile Asn Lys Asp

1 5 10

<210> 1503

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1503

Lys Ile Lys Asp Pro Asp Ala Ser Lys Pro

1 5 10

<210> 1504

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1504

Lys Leu Phe Pro Asn Ser Leu Asp Gln Thr

1 5 10

<210> 1505

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1505

Lys Gln Asp Glu Glu Gln Arg Leu Lys Glu

1 5 10

<210> 1506

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1506

Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu

1 5 10

<210> 1507

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1507

Leu Pro Pro Lys Lys Ile Lys Asp Pro Asp

1 5 10

<210> 1508

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1508

Gln Val Lys Ser Gly Thr Ile Phe Asp Asn

1 5 10

<210> 1509

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1509

Arg Lys Glu Glu Glu Glu Ala Glu Asp Lys

1 5 10

<210> 1510

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1510

Arg Leu Lys Glu Glu Glu Glu Asp Lys Lys

1 5 10

<210> 1511

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1511

Thr Lys Ala Ala Glu Lys Gln Met Lys Asp

1 5 10

<210> 1512

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1512

Ala His Gly Arg Ser Gln Val Leu Gln Gln Ser Thr Tyr Gln Leu Leu

1 5 10 15

Gln Glu Leu Cys Cys

20

<210> 1513

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1513

Ala Gln Gly Ser Val Gln Pro Gln Gln Leu Pro Gln Phe Glu Glu Ile

1 5 10 15

Arg Asn Leu Ala Leu

20

<210> 1514

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1514

Phe Cys Met Asp Val Val Leu Gln Gln His Asn Ile Ala His Gly Arg

1 5 10 15

Ser Gln Val Leu Gln

20

<210> 1515

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1515

His Asn Ile Ala His Gly Arg Ser Gln Val Leu Gln Gln Ser Thr Tyr

1 5 10 15

Gln Leu

<210> 1516

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1516

Leu Cys Cys Gln His Leu Trp Gln Ile Pro Glu Gln Ser Gln Cys Gln

1 5 10 15

Ala Ile His Asn Val

20

<210> 1517

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1517

Leu Pro Tyr Ser Gln Pro Gln Pro Phe Arg Pro Gln Gln Pro Tyr

1 5 10 15

<210> 1518

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1518

Leu Pro Tyr Ser Gln Pro Gln Pro Phe Arg Pro Gln Gln Pro Tyr Pro

1 5 10 15

Gln Pro Gln Pro Gln

20

<210> 1519

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1519

Leu Gln Gln His Asn Ile Ala His Gly Arg Ser Gln Val Leu Gln Gln

1 5 10 15

Ser Thr Tyr Gln Leu

20

<210> 1520

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1520

Leu Gln Gln Gln Leu Ile Phe Cys Met Asp Val Val Leu Gln Gln His

1 5 10 15

Asn Ile Ala His Gly

20

<210> 1521

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1521

Met Lys Thr Phe Leu Ile Leu Ala Leu Leu Ala Ile Val Ala Thr Thr

1 5 10 15

Ala Thr Thr Ala Val

20

<210> 1522

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1522

Pro Leu Val Gln Gln Gln Gln Phe Leu Gly Gln Gln Gln Pro Phe Pro

1 5 10 15

Pro Gln Gln Pro Tyr

20

<210> 1523

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1523

Pro Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln

1 5 10 15

Pro Tyr

<210> 1524

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1524

Pro Gln Gln Pro Ile Ser Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln

1 5 10 15

Gln Gln Gln Gln Gln

20

<210> 1525

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1525

Gln Phe Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro

1 5 10 15

Gln Pro Gln Pro Phe

20

<210> 1526

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1526

Gln Gly Ser Phe Arg Pro Ser Gln Gln Asn Pro Gln Ala Gln Gly Ser

1 5 10 15

Val Gln Pro Gln Gln

20

<210> 1527

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1527

Gln Asn Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu Val Gln

1 5 10 15

Gln Gln Gln Phe Leu

20

<210> 1528

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1528

Gln Pro Phe Pro Pro Gln Leu Pro Tyr Ser Gln Pro Gln Pro Phe Arg

1 5 10 15

Pro Gln Gln Pro Tyr

20

<210> 1529

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1529

Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro Phe Pro

1 5 10 15

Ser Gln Gln Pro Tyr

20

<210> 1530

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1530

Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro

1 5 10

<210> 1531

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1531

Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln Pro Phe

1 5 10 15

Arg Pro Gln Gln Pro

20

<210> 1532

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1532

Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro Phe Pro

1 5 10 15

Gln Pro Gln Leu Pro

20

<210> 1533

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1533

Gln Pro Phe Arg Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr

1 5 10 15

Ser Gln Pro Gln Gln

20

<210> 1534

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1534

Gln Pro Gln Glu Gln Val Pro Leu Val Gln Gln Gln Gln Phe Leu Gly

1 5 10 15

Gln Gln Gln Pro Phe

20

<210> 1535

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1535

Gln Pro Gln Tyr Ser Gln Pro Gln Gln Pro Ile Ser Gln Gln Gln Gln

1 5 10 15

Gln Gln Gln Gln Gln

20

<210> 1536

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1536

Gln Pro Ser Ser Gln Val Ser Phe Gln Gln Pro Leu Gln Gln Tyr Pro

1 5 10 15

Leu Gly Gln Gly Ser

20

<210> 1537

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1537

Gln Pro Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr

1 5 10 15

Ser Gln Pro Gln Pro

20

<210> 1538

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1538

Gln Pro Tyr Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu

1 5 10 15

Gln Leu Gln Pro Phe

20

<210> 1539

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1539

Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr Ser Gln Pro Gln Gln Pro

1 5 10 15

Ile Ser Gln Gln Gln

20

<210> 1540

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1540

Gln Gln Lys Gln Gln Gln Gln Pro Ser Ser Gln Val Ser Phe Gln Gln

1 5 10 15

Pro Leu Gln Gln Tyr

20

<210> 1541

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1541

Gln Gln Gln Gln Phe Leu Gly Gln Gln Gln Pro Phe Pro Pro Gln Gln

1 5 10 15

Pro Tyr

<210> 1542

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1542

Gln Gln Gln Gln Pro Ser Ser Gln Val Ser Phe Gln Gln Pro Leu Gln

1 5 10 15

Gln Tyr

<210> 1543

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1543

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ile Leu Gln

1 5 10 15

Gln Ile Leu Gln Gln

20

<210> 1544

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1544

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln

1 5 10 15

Gln Gln Gln Ile Leu

20

<210> 1545

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1545

Gln Gln Arg Pro Phe Ile Gln Pro Ser Leu

1 5 10

<210> 1546

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1546

Gln Gln Tyr Pro Leu Gly Gln Gly Ser Phe Arg Pro Ser Gln Gln Asn

1 5 10 15

Pro Gln Ala Gln Gly

20

<210> 1547

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1547

Ser Phe Gln Gln Pro Leu Gln Gln Tyr Pro Leu Gly Gln Gly Ser Phe

1 5 10 15

Arg Pro Ser Gln Gln

20

<210> 1548

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1548

Ser Gln Cys Gln Ala Ile His Asn Val Val His Ala Ile Ile Leu His

1 5 10 15

Gln Gln Gln Gln Gln

20

<210> 1549

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1549

Ser Gln Gln Asn Pro Gln Ala Gln Gly Ser Val Gln Pro Gln Gln Leu

1 5 10 15

Pro Gln Phe Glu Glu

20

<210> 1550

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1550

Thr Ala Val Arg Val Pro Val Pro Gln Leu Gln Pro Gln Asn Pro Ser

1 5 10 15

Gln Gln Gln Pro Gln

20

<210> 1551

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1551

Val Leu Gln Gln Ser Thr Tyr Gln Leu Leu Gln Glu Leu Cys Cys Gln

1 5 10 15

His Leu Trp Gln Ile

20

<210> 1552

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1552

Val Pro Gln Leu Gln Pro Gln Asn Pro Ser Gln Gln Gln Pro Gln Glu

1 5 10 15

Gln Val Pro Leu Val

20

<210> 1553

<211> 21

<212>PRT

<213> Triticum aestivum

<400> 1553

Tyr Gln Leu Leu Gln Glu Leu Cys Cys Gln His Leu Trp Gln Ile Pro

1 5 10 15

Glu Gln Ser Gln Cys

20

<210> 1554

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1554

Ala His Gly Arg Ser Gln Val Leu Gln Gln Ser Thr

1 5 10

<210> 1555

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1555

Ala Leu Gln Thr Leu Pro Ala Met Cys Asn Val Tyr

1 5 10

<210> 1556

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1556

Ala Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Thr

1 5 10

<210> 1557

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1557

Glu Glu Ile Arg Asn Leu Ala Leu Gln Thr Leu Pro

1 5 10

<210> 1558

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1558

Phe Pro Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro

1 5 10

<210> 1559

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1559

Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln

1 5 10

<210> 1560

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1560

Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro

1 5 10

<210> 1561

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1561

Phe Gln Gln Pro Leu Gln Gln Tyr Pro Leu Gly Gln

1 5 10

<210> 1562

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1562

Gly Ser Phe Arg Pro Ser Gln Gln Asn Pro Gln Ala

1 5 10

<210> 1563

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1563

His Asn Val Val His Ala Ile Ile Leu His Gln Gln

1 5 10

<210> 1564

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1564

Ile Ile Leu His Gln Gln Gln Lys Gln Gln Gln Gln

1 5 10

<210> 1565

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1565

Ile Pro Pro Tyr Cys Thr Ile Ala Pro Phe Gly Ile

1 5 10

<210> 1566

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1566

Leu Cys Cys Gln His Leu Trp Gln Ile Pro Glu Gln

1 5 10

<210> 1567

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1567

Leu Gln Gln His Asn Ile Ala His Gly Arg Ser Gln

1 5 10

<210> 1568

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1568

Leu Gln Gln Gln Leu Ile Pro Cys Met Asp Val Val

1 5 10

<210> 1569

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1569

Pro Cys Met Asp Val Val Leu Gln Gln His Asn Ile

1 5 10

<210> 1570

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1570

Pro Phe Arg Pro Gln Gln Pro Tyr Pro Gln Pro Gln

1 5 10

<210> 1571

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1571

Pro Gln Tyr Ser Gln Pro Gln Gln Pro Ile Ser Gln

1 5 10

<210> 1572

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1572

Pro Ser Gln Gln Gln Pro Gln Glu Gln Val Pro Leu

1 5 10

<210> 1573

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1573

Pro Ser Ser Gln Val Ser Phe Gln Gln Pro Leu Gln

1 5 10

<210> 1574

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1574

Pro Tyr Ser Gln Pro Gln Pro Phe Arg Pro Gln Gln

1 5 10

<210> 1575

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1575

Gln Glu Gln Val Pro Leu Val Gln Gln Gln Gln Phe

1 5 10

<210> 1576

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1576

Gln Gly Ser Val Gln Pro Gln Gln Leu Pro Gln Phe

1 5 10

<210> 1577

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1577

Gln Ile Leu Gln Gln Ile Leu Gln Gln Gln Leu Ile

1 5 10

<210> 1578

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1578

Gln Lys Gln Gln Gln Gln Pro Ser Ser Gln Val Ser

1 5 10

<210> 1579

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1579

Gln Leu Gln Pro Gln Asn Pro Ser Gln Gln Gln Pro

1 5 10

<210> 1580

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1580

Gln Gln Asn Pro Gln Ala Gln Gly Ser Val Gln Pro

1 5 10

<210> 1581

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1581

Gln Gln Pro Ile Ser Gln Gln Ile Leu Gln Gln Ile

1 5 10

<210> 1582

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1582

Gln Tyr Pro Leu Gly Gln Gly Ser Phe Arg Pro Ser

1 5 10

<210> 1583

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1583

Ser Gln Cys Gln Ala Ile His Asn Val Val His Ala

1 5 10

<210> 1584

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1584

Thr Ile Ala Pro Phe Gly Ile Phe Gly Thr Asn

1 5 10

<210> 1585

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1585

Val Leu Gln Gln Ser Thr Tyr Gln Leu Leu Gln Glu

1 5 10

<210> 1586

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1586

Val Gln Gln Gln Gln Phe Leu Gly Gln Gln Gln Pro

1 5 10

<210> 1587

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1587

Trp Gln Ile Pro Glu Gln Ser Gln Cys Gln Ala Ile

1 5 10

<210> 1588

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1588

Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu

1 5 10

<210> 1589

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1589

Tyr Pro Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro

1 5 10

<210> 1590

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1590

Tyr Gln Leu Leu Gln Glu Leu Cys Cys Gln His Leu

1 5 10

<210> 1591

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1591

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

<210> 1592

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1592

Phe Pro Gln Gln Pro Glu Gln Pro Tyr Pro Gln Gln

1 5 10

<210> 1593

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1593

Gly Gln Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu Ile Arg

1 5 10 15

<210> 1594

<211> 33

<212>PRT

<213> Triticum aestivum

<400> 1594

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln Pro

20 25 30

Phe

<210> 1595

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1595

Pro Phe Pro Gln Pro Gln Leu Pro Tyr

15

<210> 1596

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1596

Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro Gln

1 5 10 15

<210> 1597

<211> 25

<212>PRT

<213> Triticum aestivum

<400> 1597

Pro Gln Leu Pro Gln Phe Leu Gln Pro Gln Pro Tyr Pro Gln Pro Gln

1 5 10 15

Leu Pro Tyr Pro Gln Pro Gln Pro Phe

20 25

<210> 1598

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1598

Pro Gln Pro Gln Leu Pro Gln Pro Gln

15

<210> 1599

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1599

Pro Gln Pro Gln Pro Phe Leu Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Ser

<210> 1600

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1600

Pro Gln Pro Gln Pro Phe Pro Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Ser

<210> 1601

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1601

Pro Gln Gln Pro Phe Pro Ser Gln Gln Gln Gln Pro Leu Ile

1 5 10

<210> 1602

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1602

Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Gln Pro Ala

1 5 10 15

<210> 1603

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1603

Pro Gln Gln Gln Thr Leu Gln Pro Gln Gln Pro Ala Gln Leu

1 5 10

<210> 1604

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1604

Gln Ile Pro Gln Gln Gln Gln Ile Pro Gln Gln Pro Gln Gln Phe

1 5 10 15

<210> 1605

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1605

Gln Leu Gln Pro Phe Pro Gln Pro Thr Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Ser

<210> 1606

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1606

Gln Pro Gln Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Pro Phe

<210> 1607

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1607

Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Trp Gln

1 5 10 15

Pro

<210> 1608

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1608

Gln Gln Phe Ser Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln Gln

1 5 10 15

<210> 1609

<211> 18

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1609

Gln Tyr Pro Ser Gly Glu Gly Ser Phe Gln Pro Ser Gln Glu Asn Pro

1 5 10 15

Gln Ala

<210> 1610

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1610

Gln Gln Gln Pro Phe Pro

15

<210> 1611

<211> 8

<212>PRT

<213> Homo sapiens

<400> 1611

Ala Ser Phe Glu Pro Phe Ser Asn

15

<210> 1612

<211> 8

<212>PRT

<213> Homo sapiens

<400> 1612

Phe Glu Pro Phe Ser Asn Lys Gly

15

<210> 1613

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1613

Pro Gln Pro Gln Leu Pro Tyr Pro Gln

15

<210> 1614

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1614

Gln Gly Ser Phe Gln Pro Ser Gln Gln

15

<210> 1615

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1615

Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Trp Gln

1 5 10 15

Pro Gln

<210> 1616

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1616

Gln Gln Pro Gln Gln Pro Phe Pro Gln

15

<210> 1617

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1617

Gln Gln Pro Gln Gln Pro Tyr Pro Gln

15

<210> 1618

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1618

Leu Gly Glu Gly Ser Phe Gln Pro Ser Gln Glu Asn Pro

1 5 10

<210> 1619

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1619

Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

<210> 1620

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1620

Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln

1 5 10 15

<210> 1621

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1621

Gln Leu Gln Pro Phe Pro His Pro Gln Leu Pro Tyr Pro His Pro Gln

1 5 10 15

<210> 1622

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1622

Gln Leu Gln Pro Phe Pro His Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

<210> 1623

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1623

Gln Leu Gln Pro Phe Pro Gln Ala Gln Leu Pro Tyr Ser Gln Pro Gln

1 5 10 15

<210> 1624

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1624

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Glu

1 5 10 15

<210> 1625

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1625

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

<210> 1626

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1626

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Glu

1 5 10 15

<210> 1627

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1627

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln

1 5 10 15

<210> 1628

<211> 14

<212>PRT

<213> Aegilops tauschii

<400> 1628

Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Thr His

1 5 10

<210> 1629

<211> 16

<212>PRT

<213> Triticum aestivum

<400> 1629

Gln Leu Gln Pro Phe Ser Gln Pro Gln Leu Pro Tyr Ser Gln Pro Gln

1 5 10 15

<210> 1630

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1630

Gln Leu Gln Arg Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Glu

<210> 1631

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1631

Gln Pro Phe Arg Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln

1 5 10 15

<210> 1632

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1632

Gln Pro Gln Pro Phe Leu Pro Gln Leu Pro Tyr Pro Gln Pro Glu

1 5 10 15

<210> 1633

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1633

Gln Pro Gln Pro Phe Gln Pro Gln Leu Pro Tyr Pro Gln Pro Glu

1 5 10 15

<210> 1634

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1634

Pro Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1635

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1635

Phe Glu Glu Ile Arg Asn Leu Ala Leu Gln Thr Leu Pro Ala Met Cys

1 5 10 15

Asn Val Tyr Ile

20

<210> 1636

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1636

Phe Leu Gly Gln Gln Gln Ser Phe Pro Pro Gln Gln Pro Tyr Pro Gln

1 5 10 15

Pro Gln Pro Phe

20

<210> 1637

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1637

Pro Pro Tyr Cys Thr Ile Val Pro Phe Gly Ile Phe Gly Thr Asn Tyr

1 5 10 15

Arg

<210> 1638

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1638

Gln Leu Ile Pro Cys Met Asp Val Val Leu Gln Gln His Asn Ile Ala

1 5 10 15

His Gly Arg Ser

20

<210> 1639

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1639

Gln Val Leu Gln Gln Ser Thr Tyr Gln Leu Leu Gln Glu Leu Cys Cys

1 5 10 15

Gln His Leu Trp

20

<210> 1640

<211> 4

<212>PRT

<213> Triticum aestivum

<400> 1640

Phe Phe Gln Pro

1

<210> 1641

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1641

Ile Ile Leu His Gln Gln His His

15

<210> 1642

<211> 4

<212>PRT

<213> Triticum aestivum

<400> 1642

Ile Pro Glu Gln

1

<210> 1643

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1643

Pro Leu Val Gln Glu Gln Gln Phe

15

<210> 1644

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1644

Pro Gln Gln Leu Pro Gln

15

<210> 1645

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1645

Gln Gly Phe Phe Gln Pro

15

<210> 1646

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1646

Gln Gly Ser Phe Gln Pro

15

<210> 1647

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1647

Gln Leu Gln Pro Phe Pro

15

<210> 1648

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1648

Gln Pro Gln Pro Phe Pro

15

<210> 1649

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1649

Gln Pro Gln Gln Pro Phe

15

<210> 1650

<211> 8

<212>PRT

<213> Triticum aestivum

<400> 1650

Gln Val Pro Leu Val Gln Glu Gln

15

<210> 1651

<211> 6

<212>PRT

<213> Triticum aestivum

<400> 1651

Trp Gln Ile Pro Glu Gln

15

<210> 1652

<211> 11

<212>PRT

<213> Triticum aestivum

<400> 1652

Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10

<210> 1653

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1653

Phe Pro Pro Gln Gln Pro Tyr Pro Gln Pro

1 5 10

<210> 1654

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1654

Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln

1 5 10

<210> 1655

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1655

Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro

1 5 10

<210> 1656

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1656

Gln Lys Gln Gln Leu Gln Gln Gln Gln Gln

1 5 10

<210> 1657

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1657

Gln Leu Gln Pro Phe Pro Gln Pro Gln Pro

1 5 10

<210> 1658

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1658

Gln Pro Phe Pro Gln Pro Gln Pro Phe Pro

1 5 10

<210> 1659

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1659

Gln Pro Tyr Leu Gln Leu Gln Pro Phe Pro

1 5 10

<210> 1660

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1660

Gln Pro Tyr Pro Gln Pro Gln Pro Phe Pro

1 5 10

<210> 1661

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1661

Gln Gln Gln Gln Gln Ile Leu Gln Gln Ile

1 5 10

<210> 1662

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1662

Gln Gln Gln Gln Gln Gln Leu Gln Gln Gln

1 5 10

<210> 1663

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1663

Gln Gln Gln Gln Gln Gln Gln Ile Leu Gln

1 5 10

<210> 1664

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1664

Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln

1 5 10

<210> 1665

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1665

Gln Gln Gln Gln Gln Gln Gln Gln Gln Ile

1 5 10

<210> 1666

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1666

Gln Val Ser Phe Gln Gln Pro Gln Gln Gln

1 5 10

<210> 1667

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1667

Arg Asp Val Val Leu Gln Gln His Asn Ile

1 5 10

<210> 1668

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1668

Arg Asn Leu Ala Leu Gln Thr Leu Pro Ala

1 5 10

<210> 1669

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1669

Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro

1 5 10

<210> 1670

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1670

Tyr Leu Gln Leu Gln Pro Phe Pro Gln Pro

1 5 10

<210> 1671

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1671

Cys Gln Gln Leu Trp Gln Ile Pro Glu Gln

1 5 10

<210> 1672

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1672

Phe Glu Glu Ile Arg Asn Leu Ala Leu Gln

1 5 10

<210> 1673

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1673

Phe Leu Pro Gln Gln Pro Tyr Pro Gln Pro

1 5 10

<210> 1674

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1674

Phe Gln Pro Gln Gln Leu Pro Gln Phe Glu

1 5 10

<210> 1675

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1675

Gly Ser Phe Gln Pro Gln Gln Leu Pro Gln

1 5 10

<210> 1676

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1676

Ile Ala Pro Phe Gly Ile Phe Gly Thr Asn

1 5 10

<210> 1677

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1677

Leu Pro Tyr Pro Gln Pro Gln Pro Phe Leu

1 5 10

<210> 1678

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1678

Leu Ser Gln Val Ser Phe Gln Gln Pro Gln

1 5 10

<210> 1679

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1679

Pro Leu Val Gln Glu Gln Gln Phe Gln Gly

1 5 10

<210> 1680

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1680

Pro Gln Phe Glu Glu Ile Arg Asn Leu Ala

1 5 10

<210> 1681

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1681

Pro Gln Gln Leu Pro Gln Phe Glu Glu Ile

1 5 10

<210> 1682

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1682

Pro Gln Gln Pro Ile Ser Gln Gln Gln Gln

1 5 10

<210> 1683

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1683

Pro Gln Gln Gln Tyr Pro Ser Gly Gln Gly

1 5 10

<210> 1684

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1684

Gln Glu Gln Val Pro Leu Val Gln Glu Gln

1 5 10

<210> 1685

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1685

Gln Glu Ser Thr Tyr Gln Leu Val Gln Gln

1 5 10

<210> 1686

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1686

Gln Gly Phe Phe Gln Pro Ser Gln Gln Asn

1 5 10

<210> 1687

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1687

Gln Leu Pro Gln Phe Glu Glu Ile Arg Asn

1 5 10

<210> 1688

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1688

Gln Leu Gln Leu Gln Asn Pro Ser Gln Gln

1 5 10

<210> 1689

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1689

Gln Leu Trp Gln Ile Pro Glu Gln Ser Arg

1 5 10

<210> 1690

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1690

Gln Pro Phe Leu Pro Gln Gln Pro Tyr Pro

1 5 10

<210> 1691

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1691

Gln Pro Phe Pro Pro Gln Gln Pro Tyr Pro

1 5 10

<210> 1692

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1692

Gln Pro Ile Ser Gln Gln Gln Gln Gln Gln

1 5 10

<210> 1693

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1693

Gln Pro Leu Ser Gln Val Ser Phe Gln Gln

1 5 10

<210> 1694

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1694

Gln Pro Gln Pro Phe Leu Pro Gln Gln Pro

1 5 10

<210> 1695

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1695

Gln Pro Gln Tyr Ser Gln Pro Gln Gln Pro

1 5 10

<210> 1696

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1696

Gln Gln His His His Gln Glu Gln Lys

1 5 10

<210> 1697

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1697

Gln Gln Pro Gln Gln Gln Tyr Pro Ser Gly

1 5 10

<210> 1698

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1698

Gln Gln Gln Pro Leu Ser Gln Val Ser Phe

1 5 10

<210> 1699

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1699

Gln Gln Gln Gln Gln Pro Leu Ser Gln Val

1 5 10

<210> 1700

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1700

Gln Gln Gln Gln Gln Gln Gln Pro Leu Ser

1 5 10

<210> 1701

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1701

Gln Gln Tyr Pro Ser Gly Gln Gly Phe Phe

1 5 10

<210> 1702

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1702

Gln Val Pro Leu Val Gln Glu Gln Gln Phe

1 5 10

<210> 1703

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1703

Gln Tyr Ser Gln Pro Gln Gln Pro Ile Ser

1 5 10

<210> 1704

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1704

Ser Gly Gln Gly Phe Phe Gln Pro Ser Gln

1 5 10

<210> 1705

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1705

Ser Gln Pro Gln Gln Pro Ile Ser Gln Gln

1 5 10

<210> 1706

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1706

Ser Thr Thr Ile Ala Pro Phe Gly Ile Phe

1 5 10

<210> 1707

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1707

Thr Ile Ala Pro Phe Gly Ile Phe Gly Thr

1 5 10

<210> 1708

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1708

Val Leu Gln Glu Ser Thr Tyr Gln Leu Val

1 5 10

<210> 1709

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1709

Val Pro Gln Leu Gln Leu Gln Asn Pro Ser

1 5 10

<210> 1710

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1710

Val Pro Val Pro Gln Leu Gln Leu Gln Asn

1 5 10

<210> 1711

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1711

Val Arg Val Pro Val Pro Gln Leu Gln Leu

1 5 10

<210> 1712

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1712

Trp Gln Ile Pro Glu Gln Ser Arg Cys Gln

1 5 10

<210> 1713

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1713

Tyr Pro Gln Pro Gln Pro Phe Leu Pro Gln

1 5 10

<210> 1714

<211> 10

<212>PRT

<213> Triticum aestivum

<400> 1714

Tyr Pro Ser Gly Gln Gly Phe Phe Gln Pro

1 5 10

<210> 1715

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1715

Phe Pro Gln Pro Gln Gln Gln Phe Pro Gln Pro Gln

1 5 10

<210> 1716

<211> 12

<212>PRT

<213> Triticum aestivum

<400> 1716

Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln

1 5 10

<210> 1717

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1717

Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro

1 5 10 15

Gln Gln Pro Gln

20

<210> 1718

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1718

Pro His Gln Pro Gln Gln Gln Val Pro Gln Pro Gln Gln Pro Gln Gln

1 5 10 15

Pro Phe

<210> 1719

<211> 14

<212>PRT

<213> Triticum aestivum

<400> 1719

Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Arg Pro

1 5 10

<210> 1720

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1720

Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Trp Gln

1 5 10 15

Pro

<210> 1721

<211> 23

<212>PRT

<213> Secale strictum

<400> 1721

Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro

1 5 10 15

Gln Gln Pro Phe Pro Gln Pro

20

<210> 1722

<211> 19

<212>PRT

<213> Triticum aestivum

<400> 1722

Ser His Gln Gln Gln Pro Phe Pro Gln Gln Pro Tyr Pro Gln Gln Pro

1 5 10 15

Tyr Pro Ser

<210> 1723

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1723

Glu Gly Ser Phe Gln Pro Ser Gln Glu

15

<210> 1724

<211> 9

<212>PRT

<213> Triticum aestivum

<400> 1724

Gln Gly Tyr Tyr Pro Thr Ser Pro Gln

15

<210> 1725

<211> 687

<212>PRT

<213> Homo sapiens

<400> 1725

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr

1 5 10 15

Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val

20 25 30

Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg

35 40 45

Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly

50 55 60

Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg

65 70 75 80

Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln

85 90 95

Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile

100 105 110

Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser

115 120 125

Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro

130 135 140

Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val

145 150 155 160

Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys

165 170 175

Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile

180 185 190

Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly

195 200 205

Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val

210 215 220

Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg

225 230 235 240

Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly

245 250 255

Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val

260 265 270

Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu

275 280 285

Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala

290 295 300

His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe

305 310 315 320

Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys

325 330 335

Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu

340 345 350

Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr

355 360 365

Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu

370 375 380

Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp

385 390 395 400

Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile

405 410 415

Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly

420 425 430

Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly

435 440 445

Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys

450 455 460

Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly

465 470 475 480

Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr

485 490 495

Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg

500 505 510

Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr

515 520 525

Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu

530 535 540

Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu

545 550 555 560

Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu

565 570 575

Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg

580 585 590

Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser

595 600 605

Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val

610 615 620

Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp

625 630 635 640

Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro

645 650 655

Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys

660 665 670

Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala

675 680 685

<210> 1726

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1726

Phe Pro Glu Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro Gln Gln

1 5 10 15

<210> 1727

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1727

Pro Gln Thr Glu Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1728

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1728

Gln Glu Gly Tyr Tyr Pro Thr Ser Pro Glu Gln Ser Gly

1 5 10

<210> 1729

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1729

Gln Glu Gly Tyr Tyr Pro Thr Ser Pro Gln Gln Ser Gly

1 5 10

<210> 1730

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1730

Gln Gln Gly Tyr Tyr Pro Thr Ser Pro Glu Gln Ser Gly

1 5 10

<210> 1731

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1731

Ser Gly Glu Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro Gln

1 5 10

<210> 1732

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1732

Gln Leu Gln Pro Phe Ser Gln Pro Gln Leu Pro Tyr

1 5 10

<210> 1733

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1733

Gln Gln Pro Pro Phe Ala Glu Gln Glu Gln Pro Val Leu Pro Gln

1 5 10 15

<210> 1734

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1734

Gln Gln Pro Pro Phe Gly Glu Gln Glu Gln Pro Val Leu Pro Gln

1 5 10 15

<210> 1735

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1735

Gln Gln Pro Pro Phe Ser Gln Gln Gln Gln Pro Val Leu Pro Gln

1 5 10 15

<210> 1736

<211> 15

<212>PRT

<213> Triticum aestivum

<400> 1736

Gln Gln Pro Pro Phe Ser Gln Gln Gln Gln Gln Pro Leu Pro Gln

1 5 10 15

<210> 1737

<211> 20

<212>PRT

<213> Triticum aestivum

<400> 1737

Gln Gln Gln Gln Pro Pro Phe Ser Gln Gln Gln Gln Ser Pro Phe Ser

1 5 10 15

Gln Gln Gln Gln

20

<210> 1738

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1738

Ala Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1739

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1739

Lys Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1740

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1740

Pro Ala Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1741

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1741

Pro Lys Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1742

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1742

Pro Gln Ala Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1743

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1743

Pro Gln Lys Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1744

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1744

Pro Gln Pro Ala Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1745

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1745

Pro Gln Pro Glu Ala Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1746

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1746

Pro Gln Pro Glu Gln Ala Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1747

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1747

Pro Gln Pro Glu Gln Pro Ala Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1748

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1748

Pro Gln Pro Glu Gln Pro Glu Ala Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1749

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1749

Pro Gln Pro Glu Gln Pro Glu Gln Ala Phe Pro Gln Pro Gln

1 5 10

<210> 1750

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1750

Pro Gln Pro Glu Gln Pro Glu Gln Pro Ala Pro Gln Pro Gln

1 5 10

<210> 1751

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1751

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Ala Gln Pro Gln

1 5 10

<210> 1752

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1752

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Ala Pro Gln

1 5 10

<210> 1753

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1753

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Lys Pro Gln

1 5 10

<210> 1754

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1754

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Ala Gln

1 5 10

<210> 1755

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1755

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Lys Gln

1 5 10

<210> 1756

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1756

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Ala

1 5 10

<210> 1757

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1757

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Lys

1 5 10

<210> 1758

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1758

Pro Gln Pro Glu Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1759

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1759

Pro Gln Pro Glu Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1760

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with celiac disease

<400> 1760

Pro Gln Pro Gln Gln Pro Glu Gln Pro Phe Pro Gln Pro Gln

1 5 10

<210> 1761

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1761

Gln Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Gln Gln Gln Pro Leu

1 5 10 15

Ile

<210> 1762

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1762

Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Gln Leu Met

1 5 10 15

Ile

<210> 1763

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1763

Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Gln Pro Ala

1 5 10 15

Ile

<210> 1764

<211> 17

<212>PRT

<213> Triticum aestivum

<400> 1764

Gln Pro Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Gln Pro Leu

1 5 10 15

Ile

<210> 1765

<211> 18

<212>PRT

<213> Triticum aestivum

<400> 1765

Gln Gln Tyr Pro Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn

1 5 10 15

Pro Gln

<210> 1766

<211> 13

<212>PRT

<213> Triticum aestivum

<400> 1766

Ser Gly Gln Gly Ser Phe Gln Pro Ser Gln Gln Asn Pro

1 5 10

<210> 1767

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1767

Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln Asp Val Met

1 5 10 15

<210> 1768

<211> 9

<212>PRT

<213> Influenza A virus

<400> 1768

Cys Thr Glu Leu Lys Leu Ser Asp Tyr

15

<210> 1769

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1769

Asp Gly Val Ala Val Leu Lys Val Gly Gly

1 5 10

<210> 1770

<211> 17

<212>PRT

<213> Human Coxsackievirus

<400> 1770

Glu Ala Ile Pro Ala Leu Thr Ala Val Glu Thr Gly His Thr Ser Gln

1 5 10 15

Val

<210> 1771

<211> 17

<212>PRT

<213> Mycobacterium tuberculosis

<400> 1771

Glu Gly Asp Glu Ala Thr Gly Ala Asn Ile Val Lys Val Ala Leu Glu

1 5 10 15

Ala

<210> 1772

<211> 9

<212>PRT

<213> Influenza A virus

<400> 1772

Glu Leu Arg Ser Arg Tyr Trp Ala Ile

15

<210> 1773

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1773

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu

1 5 10 15

<210> 1774

<211> 20

<212>PRT

<213> Coxsackievirus B4

<400> 1774

Gly Ala His Glu Thr Ser Leu Ser Ala Ser Gly Asn Ser Ile Ile His

1 5 10 15

Tyr Thr Asn Ile

20

<210> 1775

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1775

Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala

1 5 10

<210> 1776

<211> 10

<212>PRT

<213> Mycobacterium bovis

<400> 1776

Gly Gly Val Ala Val Ile Lys Ala Gly Ala

1 5 10

<210> 1777

<211> 9

<212>PRT

<213> Influenza A virus

<400> 1777

Gly Ile Leu Gly Phe Val Phe Thr Leu

15

<210> 1778

<211> 20

<212>PRT

<213> Coxsackievirus B4

<400> 1778

Gly Asn Ser Ile Ile His Tyr Thr Asn Ile Asn Tyr Tyr Lys Asp Ala

1 5 10 15

Ala Ser Asn Ser

20

<210> 1779

<211> 10

<212>PRT

<213> Mycobacterium bovis

<400> 1779

Gly Val Thr Leu Leu Gln Ala Ala Pro Thr

1 5 10

<210> 1780

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1780

Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys

1 5 10

<210> 1781

<211> 9

<212>PRT

<213> Influenza A virus

<400> 1781

Ile Leu Arg Gly Ser Val Ala His Lys

15

<210> 1782

<211> 10

<212>PRT

<213> Mycobacterium bovis

<400> 1782

Ile Val Ala Gly Gly Gly Val Thr Leu Leu

1 5 10

<210> 1783

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1783

Ile Val Leu Gly Gly Gly Cys Ala Leu Leu

1 5 10

<210> 1784

<211> 9

<212>PRT

<213> Influenza A virus

<400> 1784

Ile Tyr Ser Thr Val Ala Ser Ser Leu

15

<210> 1785

<211> 9

<212>PRT

<213> Lymphocytic choriomeningitis virus

<400> 1785

Lys Ala Val Tyr Asn Phe Ala Thr Cys

15

<210> 1786

<211> 14

<212>PRT

<213> Human polio virus

<400> 1786

Lys Glu Val Pro Ala Leu Thr Ala Val Glu Thr Gly Ala Thr

1 5 10

<210> 1787

<211> 12

<212>PRT

<213> Coxsackievirus B4

<400> 1787

Lys Ile Leu Pro Glu Val Lys Glu Lys His Glu Phe

1 5 10

<210> 1788

<211> 10

<212>PRT

<213> Mycobacterium bovis

<400> 1788

Leu Ala Lys Leu Ala Gly Gly Val Ala Val

1 5 10

<210> 1789

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1789

Leu Ala Lys Leu Ser Asp Gly Val Ala Val

1 5 10

<210> 1790

<211> 20

<212>PRT

<213> Mus musculus

<400> 1790

Leu Val Leu Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys

1 5 10 15

Ala Pro Gly Phe

20

<210> 1791

<211> 20

<212>PRT

<213> Coxsackievirus B4

<400> 1791

Met Gly Ala Gln Val Ser Thr Gln Lys Thr Gly Ala His Glu Thr Ser

1 5 10 15

Leu Ser Ala Ser

20

<210> 1792

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1792

Asn Met Tyr Ala Met Met Ile Ala Arg Phe Lys Met Phe Pro Glu Val

1 5 10 15

Lys Glu Lys Gly

20

<210> 1793

<211> 30

<212>PRT

<213> Coxsackievirus B4

<400> 1793

Asn Tyr Tyr Lys Asp Ala Ala Ser Asn Ser Ala Asn Arg Gln Asp Phe

1 5 10 15

Thr Gln Asp Pro Ser Lys Phe Thr Glu Pro Val Lys Asp Val

20 25 30

<210> 1794

<211> 13

<212>PRT

<213> Influenza A virus

<400> 1794

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr

1 5 10

<210> 1795

<211> 15

<212>PRT

<213> Mycobacterium species

<400> 1795

Pro Tyr Ile Leu Leu Val Ser Ser Lys Val Ser Thr Val Lys Asp

1 5 10 15

<210> 1796

<211> 14

<212>PRT

<213> Clostridium tetani

<400> 1796

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu

1 5 10

<210> 1797

<211> 11

<212>PRT

<213> Influenza A virus

<400> 1797

Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Glu

1 5 10

<210> 1798

<211> 15

<212>PRT

<213> Mus musculus

<400> 1798

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly

1 5 10 15

<210> 1799

<211> 8

<212>PRT

<213> Gallus gallus

<400> 1799

Ser Ile Ile Asn Phe Glu Lys Leu

15

<210> 1800

<211> 19

<212>PRT

<213> Coxsackievirus B4

<400> 1800

Ser Lys Phe Thr Glu Pro Val Lys Asp Val Met Ile Lys Ser Leu Pro

1 5 10 15

Ala Leu Asn

<210> 1801

<211> 15

<212>PRT

<213> Mus musculus

<400> 1801

Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr

1 5 10 15

<210> 1802

<211> 24

<212>PRT

<213> Mycobacterium bovis

<400> 1802

Val Ala Gly Gly Gly Val Thr Leu Leu Gln Ala Ala Pro Thr Leu Asp

1 5 10 15

Glu Leu Lys Leu Glu Gly Asp Glu

20

<210> 1803

<211> 24

<212>PRT

<213> Homo sapiens

<400> 1803

Val Leu Gly Gly Gly Val Ala Leu Leu Arg Val Ile Pro Ala Leu Asp

1 5 10 15

Ser Leu Thr Pro Ala Asn Glu Asp

20

<210> 1804

<211> 20

<212>PRT

<213> Rubella virus

<400> 1804

Ala Phe Gly His Ser Asp Ala Ala Cys Trp Gly Phe Pro Thr Asp Thr

1 5 10 15

Val Met Ser Val

20

<210> 1805

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1805

Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala Lys

1 5 10 15

Asn Ala Gly Val

20

<210> 1806

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1806

Gly Glu Val Ile Val Thr Lys Asp Asp Ala Met Leu Leu Lys Gly Lys

1 5 10 15

Gly Asp Lys Ala

20

<210> 1807

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1807

Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu

1 5 10 15

Asp Ser Leu Thr

20

<210> 1808

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1808

Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu

1 5 10 15

Leu Ala Asp Ala

20

<210> 1809

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1809

Leu Val Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu

1 5 10 15

Val Leu Asn Arg

20

<210> 1810

<211> 21

<212>PRT

<213> Rubella virus

<400> 1810

Pro Thr Asp Val Ser Cys Glu Gly Leu Gly Ala Trp Val Pro Thr Ala

1 5 10 15

Pro Cys Ala Arg Ile

20

<210> 1811

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1811

Val Met Ala Pro Arg Thr Val Leu Leu

15

<210> 1812

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1812

Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly Ser Gly Asp

1 5 10 15

Ser Glu Asn

<210> 1813

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1813

Ala Leu Trp Met Arg Leu Leu Pro Leu

15

<210> 1814

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1814

Phe Leu Phe Ala Val Gly Phe Tyr Leu

15

<210> 1815

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1815

Phe Leu Ile Val Leu Ser Val Ala Leu

15

<210> 1816

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1816

Phe Leu Trp Ser Val Phe Met Leu Ile

15

<210> 1817

<211> 26

<212>PRT

<213> Homo sapiens

<400> 1817

Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu

1 5 10 15

Arg Met Ser Arg Leu Ser Lys Val Ala Pro

20 25

<210> 1818

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1818

Gly Ala His Gly Asp Thr Thr Pro Glu Tyr Gln Asp Leu

1 5 10

<210> 1819

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1819

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile

1 5 10

<210> 1820

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1820

His Leu Val Glu Ala Leu Tyr Leu Val

15

<210> 1821

<211> 34

<212>PRT

<213> Homo sapiens

<400> 1821

His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu

1 5 10 15

Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys Val Ala Pro Val

20 25 30

Ile Lys

<210> 1822

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1822

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His

1 5 10

<210> 1823

<211> 23

<212>PRT

<213> Homo sapiens

<400> 1823

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

1 5 10 15

Thr Pro Glu Tyr Gln Asp Leu

20

<210> 1824

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1824

Lys Leu Gln Val Phe Leu Ile Val Leu

15

<210> 1825

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1825

Leu Leu Pro Pro Leu Leu Glu His Leu

15

<210> 1826

<211> 6

<212>PRT

<213> Homo sapiens

<400> 1826

Met Ala Ser Pro Gly Ser

15

<210> 1827

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1827

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly

1 5 10 15

Ser Gly Asp Ser

20

<210> 1828

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1828

Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr

1 5 10

<210> 1829

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1829

Asn Phe Ile Arg Met Val Ile Ser Asn Pro Ala Ala Thr

1 5 10

<210> 1830

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1830

Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Ser Arg Gly

1 5 10

<210> 1831

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1831

Arg Leu Leu Cys Ala Leu Thr Ser Leu

15

<210> 1832

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1832

Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys

1 5 10 15

<210> 1833

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1833

Ser Leu Ala Ala Gly Val Lys Leu Leu

15

<210> 1834

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1834

Ser Leu Gln Lys Arg Gly Ile Val Glu Gln

1 5 10

<210> 1835

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1835

Ser Leu Gln Pro Leu Ala Leu Glu Gly

15

<210> 1836

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1836

Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly

1 5 10 15

<210> 1837

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1837

Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Ser Arg Gly

1 5 10 15

<210> 1838

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1838

Ser Leu Ser Pro Leu Gln Ala Glu Leu

15

<210> 1839

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1839

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys

15

<210> 1840

<211> 3

<212>PRT

<213> Homo sapiens

<400> 1840

Thr Ser Ile

1

<210> 1841

<211> 585

<212>PRT

<213> Homo sapiens

<400> 1841

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly

1 5 10 15

Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val

20 25 30

Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu

35 40 45

Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro

50 55 60

Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys

65 70 75 80

Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp

85 90 95

Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln

100 105 110

Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg

115 120 125

Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu

130 135 140

Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu

145 150 155 160

Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro

165 170 175

Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala

180 185 190

Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu

195 200 205

Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met

210 215 220

Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser

225 230 235 240

Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe

245 250 255

Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg

260 265 270

Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly

275 280 285

Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys

290 295 300

Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu

305 310 315 320

Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala

325 330 335

Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp

340 345 350

Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly

355 360 365

Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val

370 375 380

Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val

385 390 395 400

Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln

405 410 415

Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His

420 425 430

Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg

435 440 445

His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr

450 455 460

Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr

465 470 475 480

Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp

485 490 495

Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser

500 505 510

Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys

515 520 525

Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met

530 535 540

Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val

545 550 555 560

Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu

565 570 575

Glu Ile Glu Arg Leu Gly Gln Asp Leu

580 585

<210> 1842

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1842

Ala Phe Ile Glu Phe Lys Ala Asp Glu Lys Lys Glu Asp Glu

1 5 10

<210> 1843

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1843

Cys Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn

1 5 10 15

<210> 1844

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1844

Glu Arg Met Ser Arg Leu Ser Lys Val Ala Pro Val Ile Lys Ala

1 5 10 15

<210> 1845

<211> 18

<212>PRT

<213> Bos taurus

<400> 1845

Phe Lys Ala Asp Glu Lys Lys Phe Trp Gly Lys Tyr Leu Tyr Glu Ile

1 5 10 15

Ala Arg

<210> 1846

<211> 33

<212>PRT

<213> Homo sapiens

<400> 1846

Asn Met Tyr Ala Met Met Ile Ala Arg Phe Lys Met Phe Pro Glu Val

1 5 10 15

Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala Phe Thr Ser

20 25 30

Glu

<210> 1847

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1847

Ser Arg Leu Ser Lys Val Ala Pro Val Ile Lys Ala Arg Met Met Glu

1 5 10 15

Tyr Gly Thr Thr

20

<210> 1848

<211> 41

<212>PRT

<213> Homo sapiens

<400> 1848

Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val

1 5 10 15

Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu

20 25 30

Glu Ile Glu Arg Leu Gly Gln Asp Leu

35 40

<210> 1849

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1849

Ala Glu Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu

1 5 10 15

Glu Ser Tyr Ala

20

<210> 1850

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1850

Ala Glu Lys Asp Glu Phe Glu His Lys Arg Lys Glu Leu Glu Gln Val

1 5 10 15

Cys Asn Pro Ile

20

<210> 1851

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1851

Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg Asn Ser Thr Ile Pro

1 5 10 15

Thr Lys Gln Thr

20

<210> 1852

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1852

Ala Lys Ser Lys Asn His Thr Thr His Asn

1 5 10

<210> 1853

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1853

Ala Leu Thr Ala Val Ala Glu Glu Val

15

<210> 1854

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1854

Ala Gln Val Ala Thr Ile Ser Ala Asn Gly Asp Lys

1 5 10

<210> 1855

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1855

Ala Val Ala Asp Ile Cys Lys Lys Tyr Lys Ile Trp

1 5 10

<210> 1856

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1856

Asp Gly Val Thr Val Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys

1 5 10 15

Asn Ile Gly Ala

20

<210> 1857

<211> 31

<212>PRT

<213> Homo sapiens

<400> 1857

Asp Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr

1 5 10 15

His Gln Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly

20 25 30

<210> 1858

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1858

Asp Thr Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu

1 5 10 15

Asn Pro Gln Asn

20

<210> 1859

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1859

Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala

1 5 10 15

<210> 1860

<211> 20

<212>PRT

<213> Mus musculus

<400> 1860

Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala Asn Gly Asp Lys Asp

1 5 10 15

Ile Gly Asn Ile

20

<210> 1861

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1861

Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala Asn Gly Asp Lys Glu

1 5 10 15

Ile Gly Asn Ile

20

<210> 1862

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1862

Phe Leu Gln Asp Val Met Asn Ile Leu

15

<210> 1863

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1863

Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly

1 5 10 15

<210> 1864

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1864

Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys

1 5 10 15

Arg Gly

<210> 1865

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1865

Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile

1 5 10 15

Ala Tyr Gly Leu

20

<210> 1866

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1866

Gly Ser Gly Pro Thr Ile Glu Glu Val Asp

1 5 10

<210> 1867

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1867

His Leu Cys Gly Ser His Leu Val Glu Ala

1 5 10

<210> 1868

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1868

His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe

1 5 10 15

<210> 1869

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1869

Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu Arg Asn Val Leu

1 5 10 15

Ile Phe Asp Leu

20

<210> 1870

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1870

Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln Asp Leu

1 5 10 15

<210> 1871

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1871

Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser

1 5 10 15

Arg Leu Ser Lys

20

<210> 1872

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1872

Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys

1 5 10 15

Glu Glu Ile Glu

20

<210> 1873

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1873

Lys Ala Pro Gly Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met

1 5 10 15

Ala Ile Ala Thr

20

<210> 1874

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1874

Lys Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala

1 5 10 15

Glu Asp Glu Val

20

<210> 1875

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1875

Lys Lys Gly Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile

1 5 10 15

<210> 1876

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1876

Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala

1 5 10

<210> 1877

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1877

Lys Leu Cys Ala Leu Leu Tyr Gly Asp Ala Glu Lys

1 5 10

<210> 1878

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1878

Lys Arg Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser

1 5 10 15

Leu Phe Glu Gly

20

<210> 1879

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1879

Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His

1 5 10 15

Gln Asp

<210> 1880

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1880

Leu Glu Ser Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly

1 5 10 15

Leu Lys Gly Lys

20

<210> 1881

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1881

Leu Lys Lys Met Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly

1 5 10 15

<210> 1882

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1882

Leu Leu Ala Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr

1 5 10 15

Val Ile Ile Glu

20

<210> 1883

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1883

Leu Leu Leu Leu Asp Val Ala Pro Leu Ser Leu Gly Leu Glu Thr Ala

1 5 10 15

Gly Gly Val Met

20

<210> 1884

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1884

Leu Leu Gln Glu Tyr Asn Trp Glu Leu

15

<210> 1885

<211> 9

<212>PRT

<213> Mus musculus

<400> 1885

Leu Tyr Leu Val Cys Gly Glu Arg Gly

15

<210> 1886

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1886

Met Ala Lys Ala Ala Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser

1 5 10 15

Cys Val Gly Val

20

<210> 1887

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1887

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly

1 5 10

<210> 1888

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1888

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg

1 5 10 15

Val Leu Ala Pro

20

<210> 1889

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1889

Asn Asp Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp

1 5 10 15

Thr Glu Arg Leu

20

<210> 1890

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1890

Asn Glu Glu Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Ala Arg

1 5 10 15

Ser Ile Ala Lys

20

<210> 1891

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1891

Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg Ser

1 5 10

<210> 1892

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1892

Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile

1 5 10

<210> 1893

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1893

Asn Pro Val Glu Ile Arg Arg Gly Val Met Leu Ala Val Asp Ala Val

1 5 10 15

Ile Ala Glu Leu

20

<210> 1894

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1894

Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro Arg Ala

1 5 10

<210> 1895

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1895

Pro Ala Pro Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp Ala

1 5 10 15

Asn Gly Ile Leu

20

<210> 1896

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1896

Pro Phe Gln Val Ile Asn Asp Gly Asp Lys Pro Lys Val Gln Val Ser

1 5 10 15

Tyr Lys Gly Glu

20

<210> 1897

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1897

Pro Gly Pro Gly Gly Phe Gly Ala Gln Gly Pro Lys Gly Gly Ser Gly

1 5 10 15

Ser Gly Pro Thr

20

<210> 1898

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1898

Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser Asp Asn Gln Pro

1 5 10 15

Gly Val Leu Ile

20

<210> 1899

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1899

Pro Val Gln Leu Ser Asn Gln Trp His Val Val Gly Ala

1 5 10

<210> 1900

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1900

Gln Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln

1 5 10 15

Ser Ile Val Pro

20

<210> 1901

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1901

Gln Ser Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro

1 5 10 15

Leu Val Ile Ile Ala

20

<210> 1902

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1902

Arg Phe Glu Glu Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro

1 5 10 15

Val Glu Lys Ala

20

<210> 1903

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1903

Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn Asp Glu

1 5 10 15

Leu Glu Ile Ile

20

<210> 1904

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1904

Arg Met Met Glu Tyr Gly Thr Thr Met Val

1 5 10

<210> 1905

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1905

Arg Ser Ile Ala Lys Glu Gly Phe Glu Lys Ile Ser Lys Gly Ala Asn

1 5 10 15

Pro Val Glu Ile

20

<210> 1906

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1906

Arg Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys

1 5 10 15

Phe Gly Ala Asp

20

<210> 1907

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1907

Ser Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn

1 5 10 15

Asp Gln Gly Asn

20

<210> 1908

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1908

Ser Leu Tyr His Val Tyr Glu Val Asn Leu

1 5 10

<210> 1909

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1909

Thr Ala Arg Ala Trp Cys Gln Val Ala Gln Lys Phe

1 5 10

<210> 1910

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1910

Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His Phe

1 5 10 15

Val Glu Glu Phe

20

<210> 1911

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1911

Thr Ile Ala Asp Phe Trp Gln Met Val

15

<210> 1912

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1912

Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly Asp Thr

1 5 10 15

His Leu Gly Gly

20

<210> 1913

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1913

Thr Val Ile Ile Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp

1 5 10 15

Gly Val Thr Val

20

<210> 1914

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1914

Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr

1 5 10

<210> 1915

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1915

Val Cys Asn Pro Ile Ile Ser Gly Leu Tyr Gln Gly Ala Gly Gly Pro

1 5 10 15

Gly Pro Gly Gly

20

<210> 1916

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1916

Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Asn Ile Ile Lys

1 5 10 15

Asn Arg Glu Gly

20

<210> 1917

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1917

Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln

1 5 10

<210> 1918

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1918

Val Ile Ala Glu Leu Lys Lys Gln Ser Lys Pro Val Thr Thr Pro Glu

1 5 10 15

Glu Ile Ala Gln

20

<210> 1919

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1919

Val Ile Val Met Leu Thr Pro Leu Val

15

<210> 1920

<211> 24

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1920

Val Leu Gly Gly Gly Val Leu Leu Leu Arg Val Ile Pro Ala Leu Asp

1 5 10 15

Ser Leu Thr Pro Ala Asn Glu Asp

20

<210> 1921

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1921

Val Met Asn Ile Leu Leu Gln Tyr Val Val

1 5 10

<210> 1922

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1922

Val Asn Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg

1 5 10 15

Thr Ala Leu Leu

20

<210> 1923

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1923

Val Gln Lys Leu Leu Gln Asp Phe Phe Asn Gly Arg Asp Leu Asn Lys

1 5 10 15

Ser Ile Asn Pro

20

<210> 1924

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1924

Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val Glu Glu Gly Ile

1 5 10 15

Val Leu Gly Gly

20

<210> 1925

<211> 9

<212>PRT

<213> Mus musculus

<400> 1925

Val Tyr Leu Lys Thr Asn Val Phe Leu

15

<210> 1926

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1926

Ala Lys Gly Thr Thr Gly Phe Glu Ala His Val Asp Lys

1 5 10

<210> 1927

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1927

Ala Leu Trp Gly Pro Asp Pro Ala Ala Ala

1 5 10

<210> 1928

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1928

Phe Asp Arg Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu

1 5 10 15

<210> 1929

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1929

Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile

1 5 10 15

Asp Phe Leu Ile

20

<210> 1930

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1930

Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp

1 5 10

<210> 1931

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1931

Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly

1 5 10 15

Gln

<210> 1932

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1932

Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser

1 5 10 15

Leu

<210> 1933

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1933

Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly

1 5 10

<210> 1934

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1934

Ile Pro Pro Ser Leu Arg Tyr Leu Glu Asp Asn Glu Glu Arg Met Ser

1 5 10 15

Arg Leu Ser Lys

20

<210> 1935

<211> 20

<212>PRT

<213> Mus musculus

<400> 1935

Lys Gly Asp Lys Ala His Ile Glu Lys Arg Ile Gln Glu Ile Thr Glu

1 5 10 15

Gln Leu Asp Ile

20

<210> 1936

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1936

Lys His Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln

1 5 10 15

<210> 1937

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1937

Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu

1 5 10 15

<210> 1938

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1938

Leu Ala Leu Glu Gly Ser Leu Gln Lys

15

<210> 1939

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1939

Leu Ala Leu Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His

1 5 10 15

Leu

<210> 1940

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1940

Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly Pro Asp Pro Ala

1 5 10 15

Ala

<210> 1941

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1941

Leu Asn Ile Asp Leu Leu Trp Ser Val

15

<210> 1942

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1942

Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His Ser His Phe

1 5 10

<210> 1943

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1943

Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser

1 5 10 15

<210> 1944

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1944

Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr

1 5 10 15

Thr

<210> 1945

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1945

Leu Trp Glu Ile Glu Phe Ala Lys Gln Leu

1 5 10

<210> 1946

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1946

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu

1 5 10 15

<210> 1947

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1947

Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu Met

1 5 10 15

His Cys Gln Thr

20

<210> 1948

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1948

Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val

1 5 10 15

Glu

<210> 1949

<211> 14

<212>PRT

<213> Homo sapiens

<400> 1949

Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly Ser

1 5 10

<210> 1950

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1950

Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys

1 5 10 15

Gly

<210> 1951

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1951

Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly

1 5 10 15

Pro

<210> 1952

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1952

Arg Leu Ile Ala Phe Thr Ser Glu His Ser His Phe

1 5 10

<210> 1953

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1953

Arg Leu Leu Pro Leu Leu Ala Leu Leu

15

<210> 1954

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1954

Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr Gln Pro Leu

1 5 10 15

<210> 1955

<211> 20

<212>PRT

<213> Mus musculus

<400> 1955

Arg Thr Ala Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr

1 5 10 15

Ala Glu Ala Val

20

<210> 1956

<211> 20

<212>PRT

<213> Mus musculus

<400> 1956

Thr Ala Glu Ala Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro

1 5 10 15

Gly Met Gly Ala

20

<210> 1957

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1957

Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Phe Tyr Val Thr Leu

1 5 10 15

Lys Lys Met Arg

20

<210> 1958

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1958

Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu

1 5 10 15

Ala

<210> 1959

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1959

Val Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln

1 5 10 15

Pro

<210> 1960

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1960

Val Leu Phe Gly Leu Gly Phe Ala Ile

15

<210> 1961

<211> 24

<212>PRT

<213> Homo sapiens

<400> 1961

Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp

1 5 10 15

Ser Leu Thr Pro Ala Asn Glu Asp

20

<210> 1962

<211> 8

<212>PRT

<213> Homo sapiens

<400> 1962

Trp Gly Pro Asp Pro Ala Ala Ala

15

<210> 1963

<211> 582

<212>PRT

<213> Homo sapiens

<400> 1963

Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly Ser Gly Asp

1 5 10 15

Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val Ala Gln Lys

20 25 30

Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu Tyr Gly Asp

35 40 45

Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro Arg Ala Ala

50 55 60

Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys Ser Cys Ser

65 70 75 80

Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp Leu Leu Pro

85 90 95

Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln Asp Val Met

100 105 110

Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg Ser Thr Lys

115 120 125

Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu Tyr Asn Trp

130 135 140

Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu Met His Cys

145 150 155 160

Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro Arg Tyr Phe

165 170 175

Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala Ala Asp Trp

180 185 190

Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro

195 200 205

Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met Arg Glu Ile

210 215 220

Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser Pro Gly Gly

225 230 235 240

Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe Lys Met Phe

245 250 255

Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala

260 265 270

Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly Ala Ala Ala

275 280 285

Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys Asp Glu Arg

290 295 300

Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu Glu Ala Lys

305 310 315 320

Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala Gly Thr Thr

325 330 335

Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp Ile Cys Lys

340 345 350

Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly Gly Gly Leu

355 360 365

Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val Glu Arg Ala

370 375 380

Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val Pro Leu Gln

385 390 395 400

Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln Asn Cys Asn

405 410 415

Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His Tyr Asp Leu

420 425 430

Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg His Val Asp

435 440 445

Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr Thr Gly Phe

450 455 460

Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Asn

465 470 475 480

Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp Gly Lys Pro

485 490 495

Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr

500 505 510

Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys Val Ala Pro

515 520 525

Val Ile Lys Ala Arg Met Glu Tyr Gly Thr Thr Met Val Ser Tyr

530 535 540

Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn

545 550 555 560

Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu

565 570 575

Arg Leu Gly Gln Asp Leu

580

<210> 1964

<211> 11

<212>PRT

<213> Homo sapiens

<400> 1964

Ala Phe Thr Ser Glu His Ser His Phe Ser Leu

1 5 10

<210> 1965

<211> 12

<212>PRT

<213> Homo sapiens

<400> 1965

Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys

1 5 10

<210> 1966

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1966

Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg

1 5 10 15

Gly

<210> 1967

<211> 9

<212>PRT

<213> Homo sapiens

<400> 1967

Ala Leu Tyr Leu Val Cys Gly Glu Arg

15

<210> 1968

<211> 18

<212>PRT

<213> Homo sapiens

<400> 1968

Ala Asn Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu

1 5 10 15

Leu Glu

<210> 1969

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1969

Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu

1 5 10 15

Gly Gln Asp Leu

20

<210> 1970

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1970

Ala Tyr Asn Lys Ala Asn Trp Phe Leu

15

<210> 1971

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1971

Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn

1 5 10 15

<210> 1972

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1972

Cys His Ala Val Lys Val Gly Asn Pro Ser Cys

1 5 10

<210> 1973

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1973

Cys Pro Arg Asp Leu Asn Gly Lys Ser Gly Cys

1 5 10

<210> 1974

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1974

Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala

1 5 10 15

Gly Thr Thr Val

20

<210> 1975

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1975

Glu Arg Met Ser Arg Leu Ser Lys Val Ala Pro Val Ile Lys Ala Arg

1 5 10 15

Met Met Glu Tyr

20

<210> 1976

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1976

Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala Phe

1 5 10 15

Thr Ser Glu His

20

<210> 1977

<211> 11

<212>PRT

<213> Homo sapiens

<400> 1977

Phe Lys Met Phe Pro Glu Val Lys Glu Lys Gly

1 5 10

<210> 1978

<211> 10

<212>PRT

<213> Homo sapiens

<400> 1978

Phe Thr Ser Glu His Ser His Phe Ser Leu

1 5 10

<210> 1979

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1979

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr

1 5 10 15

Leu

<210> 1980

<211> 13

<212>PRT

<213> Homo sapiens

<400> 1980

Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp

1 5 10

<210> 1981

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1981

Gly Asp Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala

1 5 10 15

Thr His Gln Asp

20

<210> 1982

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1982

Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu

1 5 10 15

Asp

<210> 1983

<211> 21

<212>PRT

<213> Homo sapiens

<400> 1983

Gly Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly

1 5 10 15

Val Glu Arg Ala Asn

20

<210> 1984

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1984

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln

1 5 10 15

<210> 1985

<211> 19

<212>PRT

<213> Homo sapiens

<400> 1985

Gly Leu Met Gln Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln

1 5 10 15

Gln Asp Lys

<210> 1986

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1986

Gly Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro

1 5 10 15

Leu

<210> 1987

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1987

Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg

1 5 10 15

<210> 1988

<211> 17

<212>PRT

<213> Homo sapiens

<400> 1988

Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile

1 5 10 15

Cys

<210> 1989

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1989

Gly Thr Thr Met Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe

1 5 10 15

Phe Arg Met Val

20

<210> 1990

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1990

His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys

1 5 10 15

<210> 1991

<211> 15

<212>PRT

<213> Homo sapiens

<400> 1991

His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe

1 5 10 15

<210> 1992

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1992

His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser Leu Arg Thr Leu

1 5 10 15

Glu Asp Asn Glu

20

<210> 1993

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1993

Ile Met Glu Gln Cys Phe Glu Ile Gly Cys Pro Ala Thr Asn

1 5 10

<210> 1994

<211> 16

<212>PRT

<213> Homo sapiens

<400> 1994

Ile Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser

1 5 10 15

<210> 1995

<211> 20

<212>PRT

<213> Homo sapiens

<400> 1995

Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu

1 5 10 15

Glu Ile Glu Arg

20

<210> 1996

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1996

Lys Tyr Asn Lys Ala Ala Trp Phe Leu

15

<210> 1997

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1997

Lys Tyr Asn Lys Ala Asn Ala Phe Leu

15

<210> 1998

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1998

Lys Tyr Asn Lys Ala Asn Trp Ala Leu

15

<210> 1999

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 1999

Lys Tyr Asn Lys Ala Asn Trp Phe Leu

15

<210> 2000

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2000

Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu

1 5 10 15

Arg

<210> 2001

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2001

Leu Met Glu Pro Cys Tyr Ala Trp Gly Cys Thr Gly Pro Lys

1 5 10

<210> 2002

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2002

Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe

1 5 10 15

<210> 2003

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2003

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys

1 5 10 15

<210> 2004

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2004

Met Ile Ala Arg Phe Lys Met Phe Pro Glu Val Lys Glu Lys Gly

1 5 10 15

<210> 2005

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2005

Met Met Ile Ala Arg Phe Lys Met Phe Pro Glu Val Lys Glu Lys Gly

1 5 10 15

Met Ala Ala Leu

20

<210> 2006

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2006

Met Tyr Ala Met Ile Ala Arg Phe Lys

1 5 10

<210> 2007

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2007

Met Tyr Ala Met Met Ile Ala Arg Phe Lys Met Phe

1 5 10

<210> 2008

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2008

Asn Asp Ser Gln Cys Trp Lys Leu Gly Cys Ile Ala Glu Lys

1 5 10

<210> 2009

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2009

Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp

1 5 10

<210> 2010

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2010

Asn Pro Glu Asp Cys Phe Lys Thr Gly Cys Asn Ser Pro Thr

1 5 10

<210> 2011

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2011

Asn Tyr Ala Phe Leu His Ala Thr Asp Leu Leu Pro

1 5 10

<210> 2012

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2012

Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu

1 5 10 15

Ser Lys Val Ala

20

<210> 2013

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2013

Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser

1 5 10 15

Tyr Gln Pro Leu

20

<210> 2014

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2014

Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val

1 5 10 15

<210> 2015

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2015

Arg Phe Lys Met Phe Pro Glu Val Lys

15

<210> 2016

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2016

Arg Phe Lys Met Phe Pro Glu Val Lys Glu

1 5 10

<210> 2017

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2017

Arg Phe Lys Met Phe Pro Glu Val Lys Glu Lys

1 5 10

<210> 2018

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2018

Ser His Leu Val Glu Ala Leu Tyr Leu Val

1 5 10

<210> 2019

<211> 14

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2019

Ser Asn Val Glu Cys Asp Gly Leu Asn Cys Asp Trp Ile Ile

1 5 10

<210> 2020

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2020

Ser Pro Ser Leu Trp Glu Ile Glu Phe Ala Lys Gln Leu Ala Ser Val

1 5 10 15

<210> 2021

<211> 16

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2021

Ser Pro Ser Leu Trp Glu Ile Glu Ile Ala Lys Gln Leu Ala Ser Val

1 5 10 15

<210> 2022

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2022

Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly

1 5 10 15

Gly

<210> 2023

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2023

Thr Ser Glu His Ser His Phe Ser Leu

15

<210> 2024

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2024

Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr

1 5 10 15

<210> 2025

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2025

Val Met Asn Ile Leu Leu Gln Tyr Val

15

<210> 2026

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2026

Tyr Glu Met Val Phe Asp Gly Lys Pro Gln His Thr Asn Val Cys Phe

1 5 10 15

Trp Tyr Ile Pro

20

<210> 2027

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2027

Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr

1 5 10 15

<210> 2028

<211> 979

<212>PRT

<213> Homo sapiens

<400> 2028

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu

1 5 10 15

Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys

20 25 30

Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser

35 40 45

His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val

50 55 60

Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu

65 70 75 80

Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser

85 90 95

Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg

100 105 110

Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly

115 120 125

Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp

130 135 140

Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro

145 150 155 160

Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu

165 170 175

Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro

180 185 190

Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro

195 200 205

Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu

210 215 220

Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala

225 230 235 240

Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His

245 250 255

Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu

260 265 270

Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro

275 280 285

Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg

290 295 300

Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg

305 310 315 320

Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln

325 330 335

Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu

340 345 350

Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro

355 360 365

Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp

370 375 380

Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu

385 390 395 400

Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro

405 410 415

Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro

420 425 430

Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys

435 440 445

Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala

450 455 460

Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro

465 470 475 480

Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His

485 490 495

Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro

500 505 510

Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala

515 520 525

Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln

530 535 540

Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala

545 550 555 560

Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser

565 570 575

Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val

580 585 590

Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp

595 600 605

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

610 615 620

Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser

625 630 635 640

Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser

645 650 655

Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His

660 665 670

Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp

675 680 685

Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg

690 695 700

Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln

705 710 715 720

Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys

725 730 735

Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys

740 745 750

Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser

755 760 765

Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln

770 775 780

Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu

785 790 795 800

Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly

805 810 815

Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr

820 825 830

His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp

835 840 845

Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr

850 855 860

Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr

865 870 875 880

Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys

885 890 895

Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly

900 905 910

Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg

915 920 925

Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His

930 935 940

Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu

945 950 955 960

Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala

965 970 975

Leu Pro Gln

<210> 2029

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2029

Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys Asp

1 5 10 15

Glu Arg Gly Lys

20

<210> 2030

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2030

Ala Phe Ile Lys Ala Thr Gly Lys Lys Glu Asp Glu

1 5 10

<210> 2031

<211> 11

<212>PRT

<213> Mus musculus

<400> 2031

Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr

1 5 10

<210> 2032

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2032

Cys Ala Tyr Gln Ala Glu Pro Asn Thr Cys Ala Thr Ala

1 5 10

<210> 2033

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2033

Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp

1 5 10

<210> 2034

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2034

Asp Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu

1 5 10

<210> 2035

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2035

Glu Lys Ala His Arg Pro Ile Trp Ala Arg Met Asp Ala Lys Lys

1 5 10 15

<210> 2036

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2036

Glu Tyr Val Thr Leu Lys Lys Met Arg Glu Ile Ile Gly Trp Pro Gly

1 5 10 15

Gly Ser Gly Asp

20

<210> 2037

<211> 15

<212>PRT

<213> Bos taurus

<400> 2037

Phe Lys Ala Asp Glu Lys Lys Phe Trp Gly Lys Tyr Leu Tyr Glu

1 5 10 15

<210> 2038

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2038

Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr Gln

1 5 10 15

Phe His Phe

<210> 2039

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2039

Gly Met Ala Ala Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His Ser

1 5 10 15

His Phe Ser Leu

20

<210> 2040

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2040

Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro Ala Leu

1 5 10

<210> 2041

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2041

Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly

1 5 10 15

Ile Val

<210> 2042

<211> 20

<212>PRT

<213> Mus musculus

<400> 2042

His Thr Pro Gly Val His Met Ala Ser Leu Ser Val Tyr Leu Lys Thr

1 5 10 15

Asn Val Phe Leu

20

<210> 2043

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2043

Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met Val Ser Tyr

1 5 10 15

<210> 2044

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2044

Ile Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn

1 5 10 15

Ala Ser Pro Ile

20

<210> 2045

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2045

Lys Tyr Asn Lys Ala Asn Val Phe Leu

15

<210> 2046

<211> 23

<212>PRT

<213> Homo sapiens

<400> 2046

Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn

1 5 10 15

Thr Cys Ala Thr Ala Gln Gly

20

<210> 2047

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2047

Leu Ala Lys Leu Ser Asp Gly Val Ala Val Leu Lys Val Gly Gly

1 5 10 15

<210> 2048

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2048

Leu Glu Ile Leu Ala Glu His Val His Met Ser Ser Gly

1 5 10

<210> 2049

<211> 19

<212>PRT

<213> Mus musculus

<400> 2049

Leu His Arg Ser Gly Val Leu Ile Ile His His Leu Gln Glu Asp Tyr

1 5 10 15

Arg Thr Tyr

<210> 2050

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2050

Leu Tyr His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys

1 5 10 15

Glu Asp Phe Leu

20

<210> 2051

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2051

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly

1 5 10 15

Ser

<210> 2052

<211> 37

<212>PRT

<213> Homo sapiens

<400> 2052

Met Gly Ile Leu Lys Leu Gln Val Phe Leu Ile Val Leu Ser Val Ala

1 5 10 15

Leu Asn His Leu Lys Ala Thr Pro Ile Glu Ser His Gln Val Glu Lys

20 25 30

Arg Lys Cys Asn Thr

35

<210> 2053

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2053

Met Val Phe Asp Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp

1 5 10 15

<210> 2054

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2054

Met Val Trp Glu Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu

1 5 10 15

Val Glu Asp Gly Val

20

<210> 2055

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2055

Asn Arg Val Ala Pro Asn Val Arg Gln

15

<210> 2056

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2056

Pro Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser His Thr

1 5 10

<210> 2057

<211> 15

<212>PRT

<213> Mus musculus

<400> 2057

Pro His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly

1 5 10 15

<210> 2058

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2058

Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro Tyr

1 5 10

<210> 2059

<211> 15

<212>PRT

<213> Mus musculus

<400> 2059

Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met Val

1 5 10 15

<210> 2060

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2060

Arg Ser Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val

1 5 10

<210> 2061

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2061

Ser Glu His Ile Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu

1 5 10 15

Lys Asn Val Gln

20

<210> 2062

<211> 15

<212>PRT

<213> Mus musculus

<400> 2062

Ser His Leu Val Glu Ala Leu Tyr Leu Val Ala Gly Glu Arg Gly

1 5 10 15

<210> 2063

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2063

Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val

1 5 10 15

Asn Ala Ile Leu Lys

20

<210> 2064

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2064

Ser Leu Tyr His Val Tyr Glu Val Asn Leu Val Ser Glu

1 5 10

<210> 2065

<211> 10

<212>PRT

<213> Mus musculus

<400> 2065

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn

1 5 10

<210> 2066

<211> 18

<212>PRT

<213> Mus musculus

<400> 2066

Thr Ala Ala Leu Ser Tyr Thr Ile Ser Arg Met Glu Glu Ser Ser Val

1 5 10 15

Thr Leu

<210> 2067

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2067

Thr Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp

1 5 10 15

<210> 2068

<211> 13

<212>PRT

<213> Mus musculus

<400> 2068

Thr Gln Tyr Glu Ala Val Ala Thr Ser Asn Met Gln Glu

1 5 10

<210> 2069

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2069

Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg Met Ala

1 5 10

<210> 2070

<211> 16

<212>PRT

<213> Mus musculus

<400> 2070

Val Pro Pro Ser Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser

1 5 10 15

<210> 2071

<211> 16

<212>PRT

<213> Mus musculus

<400> 2071

Val Pro Thr Ser Leu Arg Arg Leu Glu Gln Pro Asn Val Ala Ile Ser

1 5 10 15

<210> 2072

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2072

Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His

1 5 10 15

Ser Ser

<210> 2073

<211> 23

<212>PRT

<213> Mus musculus

<400> 2073

Trp Tyr Val Met Val Thr Ala Ala Leu Ser Tyr Thr Ile Ser Arg Met

1 5 10 15

Glu Glu Ser Ser Val Thr Leu

20

<210> 2074

<211> 979

<212>PRT

<213> Homo sapiens

<400> 2074

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu

1 5 10 15

Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys

20 25 30

Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser

35 40 45

His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val

50 55 60

Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu

65 70 75 80

Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser

85 90 95

Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg

100 105 110

Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly

115 120 125

Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp

130 135 140

Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro

145 150 155 160

Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu

165 170 175

Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro

180 185 190

Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro

195 200 205

Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu

210 215 220

Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala

225 230 235 240

Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His

245 250 255

Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu

260 265 270

Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro

275 280 285

Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg

290 295 300

Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg

305 310 315 320

Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln

325 330 335

Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu

340 345 350

Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro

355 360 365

Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp

370 375 380

Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu

385 390 395 400

Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro

405 410 415

Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro

420 425 430

Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys

435 440 445

Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala

450 455 460

Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro

465 470 475 480

Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His

485 490 495

Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro

500 505 510

Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala

515 520 525

Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln

530 535 540

Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala

545 550 555 560

Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser

565 570 575

Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val

580 585 590

Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp

595 600 605

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

610 615 620

Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser

625 630 635 640

Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser

645 650 655

Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His

660 665 670

Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp

675 680 685

Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg

690 695 700

Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln

705 710 715 720

Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys

725 730 735

Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys

740 745 750

Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser

755 760 765

Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln

770 775 780

Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu

785 790 795 800

Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly

805 810 815

Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr

820 825 830

His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp

835 840 845

Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr

850 855 860

Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr

865 870 875 880

Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys

885 890 895

Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly

900 905 910

Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg

915 920 925

Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His

930 935 940

Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu

945 950 955 960

Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala

965 970 975

Leu Pro Gln

<210> 2075

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2075

Ala Val Arg Pro Leu Trp Val Arg Met Glu Ala

1 5 10

<210> 2076

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2076

Asp Thr Thr Phe Glu Tyr Gln Asp Leu Cys

1 5 10

<210> 2077

<211> 11

<212>PRT

<213> Mus musculus

<400> 2077

Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly

1 5 10

<210> 2078

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2078

Glu Leu Ala Glu Tyr Leu Tyr Asn Ile

15

<210> 2079

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2079

Gly Ala His Gly Asp Thr Thr Phe Glu Tyr

1 5 10

<210> 2080

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2080

Gly Glu Arg Ala Lys Arg Ser

15

<210> 2081

<211> 12

<212>PRT

<213> Bos taurus

<400> 2081

Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser

1 5 10

<210> 2082

<211> 15

<212>PRT

<213> Bos taurus

<400> 2082

Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln

1 5 10 15

<210> 2083

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2083

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser

1 5 10

<210> 2084

<211> 23

<212>PRT

<213> Mus musculus

<400> 2084

Gly Arg His Ser Ala Glu Tyr Tyr Asn Lys Gln Tyr Leu Glu Arg Thr

1 5 10 15

Arg Ala Glu Leu Asp Thr Ala

20

<210> 2085

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2085

Ile Leu Met His Cys Gln Thr Thr Leu

15

<210> 2086

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2086

Leu Asp Gln Arg Ser Ser Lys

15

<210> 2087

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2087

Leu Asp Gln Ser Arg Leu Lys

15

<210> 2088

<211> 19

<212>PRT

<213> Mus musculus

<400> 2088

Leu Lys Ile Cys Gly Phe Leu Gln Arg Thr Asn Ser Leu Glu Glu Lys

1 5 10 15

Ser Arg Leu

<210> 2089

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2089

Leu Pro Gly Glu Arg Gln Ile

15

<210> 2090

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2090

Leu Pro Asn Arg Ser Gln Ile

15

<210> 2091

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2091

Asn Ile Lys Ser Ser Leu Pro

15

<210> 2092

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2092

Asn Pro Gly Ser Ser Leu Gly

15

<210> 2093

<211> 17

<212>PRT

<213> Mus musculus

<400> 2093

Asn Ser Gln Pro Glu Ile Leu Glu Arg Thr Arg Ala Glu Val Asp Thr

1 5 10 15

Ala

<210> 2094

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2094

Pro Asp Gly Ser Arg Leu Val

15

<210> 2095

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2095

Pro Gly Ser Arg Leu Gln Pro

15

<210> 2096

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2096

Pro Gly Thr Arg Leu Gln Pro

15

<210> 2097

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2097

Pro Ser Arg Leu Val Asn Gln

15

<210> 2098

<211> 12

<212>PRT

<213> Bos taurus

<400> 2098

Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln Leu

1 5 10

<210> 2099

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2099

Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu

1 5 10

<210> 2100

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2100

Gln Gly Glu Arg Ser Gly Pro

15

<210> 2101

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2101

Gln Arg Ser Gly Arg Gly Pro

15

<210> 2102

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2102

Ser His Leu Val Glu Ala Leu Ala Leu Val Ala Gly Glu Arg Gly

1 5 10 15

<210> 2103

<211> 8

<212>PRT

<213> Mus musculus

<400> 2103

Ser His Leu Val Glu Ala Leu Tyr

15

<210> 2104

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2104

Ser Thr Gly Glu Arg Ile Gln

15

<210> 2105

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2105

Thr Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Leu Glu

1 5 10 15

Tyr Val Thr Leu

20

<210> 2106

<211> 13

<212>PRT

<213> Bos taurus

<400> 2106

Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala

1 5 10

<210> 2107

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2107

Val Gly Glu Arg Gly Ser Lys

15

<210> 2108

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2108

Val Ile Gln Gly Ser Gln Leu

15

<210> 2109

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2109

Val Ile Gln Gly Ser Arg Leu

15

<210> 2110

<211> 24

<212>PRT

<213> Mus musculus

<400> 2110

Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp

1 5 10 15

Ser Leu Lys Pro Ala Asn Glu Asp

20

<210> 2111

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2111

Val Pro Gln Gln Ser Ile Pro

15

<210> 2112

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2112

Val Arg Gly Arg Gly Ser Lys

15

<210> 2113

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2113

Val Ser Arg Ser Leu Leu Asp

15

<210> 2114

<211> 585

<212>PRT

<213> Homo sapiens

<400> 2114

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly

1 5 10 15

Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val

20 25 30

Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu

35 40 45

Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro

50 55 60

Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys

65 70 75 80

Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp

85 90 95

Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln

100 105 110

Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg

115 120 125

Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu

130 135 140

Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu

145 150 155 160

Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro

165 170 175

Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala

180 185 190

Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu

195 200 205

Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met

210 215 220

Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser

225 230 235 240

Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe

245 250 255

Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg

260 265 270

Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly

275 280 285

Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys

290 295 300

Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu

305 310 315 320

Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala

325 330 335

Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp

340 345 350

Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly

355 360 365

Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val

370 375 380

Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val

385 390 395 400

Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln

405 410 415

Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His

420 425 430

Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg

435 440 445

His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr

450 455 460

Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr

465 470 475 480

Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp

485 490 495

Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser

500 505 510

Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys

515 520 525

Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met

530 535 540

Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val

545 550 555 560

Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu

565 570 575

Glu Ile Glu Arg Leu Gly Gln Asp Leu

580 585

<210> 2115

<211> 30

<212>PRT

<213> Homo sapiens

<400> 2115

Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu

1 5 10 15

Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr

20 25 30

<210> 2116

<211> 9

<212>PRT

<213> Mus musculus

<400> 2116

Ala Leu Ile Pro Tyr Cys Val His Met

15

<210> 2117

<211> 9

<212>PRT

<213> Mus musculus

<400> 2117

Ala Leu Ser Tyr Thr Ile Ser Arg Met

15

<210> 2118

<211> 9

<212>PRT

<213> Mus musculus

<400> 2118

Ala Thr His Phe Pro His Gln Val Ile

15

<210> 2119

<211> 9

<212>PRT

<213> Mus musculus

<400> 2119

Cys Ala Leu Thr Ser Leu Thr Thr Met

15

<210> 2120

<211> 9

<212>PRT

<213> Mus musculus

<400> 2120

Cys Ala Asn Pro Asp Trp Ile His Ile

15

<210> 2121

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2121

Cys Gly Arg His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala

1 5 10 15

Lys Gly Thr Thr Gly

20

<210> 2122

<211> 9

<212>PRT

<213> Mus musculus

<400> 2122

Cys Lys Ser Ala Ser Ile Pro Leu Met

15

<210> 2123

<211> 9

<212>PRT

<213> Mus musculus

<400> 2123

Cys Gln Gly Glu Asn Gly Thr Lys Pro

15

<210> 2124

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2124

Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu

1 5 10 15

Glu Ala Lys Gln

20

<210> 2125

<211> 9

<212>PRT

<213> Mus musculus

<400> 2125

Asp Phe Leu His Arg Ser Gly Val Leu

15

<210> 2126

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2126

Asp Ser Tyr Glu Ile Met Gln Gly Arg Ala Val Val

1 5 10

<210> 2127

<211> 9

<212>PRT

<213> Mus musculus

<400> 2127

Asp Tyr Arg Thr Tyr Tyr Gly Phe Leu

15

<210> 2128

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2128

Glu Glu Ile Leu Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys

1 5 10 15

Thr Gly His Pro

20

<210> 2129

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2129

Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val

1 5 10 15

Pro Leu Gln Cys

20

<210> 2130

<211> 9

<212>PRT

<213> Mus musculus

<400> 2130

Glu Ser Ser Val Thr Leu His Arg Leu

15

<210> 2131

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2131

Glu Tyr Gly Thr Thr Met Val Ser Tyr Gln Pro Leu Gly Asp Lys Val

1 5 10 15

Asn Phe Phe Arg

20

<210> 2132

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2132

Glu Tyr Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val

1 5 10 15

Phe Asp Gly Lys

20

<210> 2133

<211> 9

<212>PRT

<213> Mus musculus

<400> 2133

Phe Ala Ile Asn Ser Glu Met Phe Leu

15

<210> 2134

<211> 9

<212>PRT

<213> Mus musculus

<400> 2134

Phe Glu His Thr Pro Gly Val His Met

15

<210> 2135

<211> 9

<212>PRT

<213> Mus musculus

<400> 2135

Phe Gly Ile Asp Leu Leu Trp Ser Val

15

<210> 2136

<211> 9

<212>PRT

<213> Mus musculus

<400> 2136

Phe Leu His Arg Ser Gly Val Leu Ile

15

<210> 2137

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2137

Phe Leu Trp Ser Val Phe Trp Leu Ile

15

<210> 2138

<211> 9

<212>PRT

<213> Mus musculus

<400> 2138

Gly Asp Pro Arg Asn Ile Phe Ser Ile

15

<210> 2139

<211> 9

<212>PRT

<213> Mus musculus

<400> 2139

Gly Phe Ala Ile Asn Ser Glu Met Phe

15

<210> 2140

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2140

Gly Gly Ser Gly Asp Gly Ile Phe Ser Pro Gly Gly Ala Ile Ser Asn

1 5 10 15

Met Tyr Ala Met

20

<210> 2141

<211> 9

<212>PRT

<213> Mus musculus

<400> 2141

Gly His Ala Met Gly Ser Ser Cys Val

15

<210> 2142

<211> 9

<212>PRT

<213> Mus musculus

<400> 2142

Gly Leu Val Arg Asn Leu Gly Val Leu

15

<210> 2143

<211> 9

<212>PRT

<213> Mus musculus

<400> 2143

Gly Thr Lys Pro Ser Phe Arg Leu Leu

15

<210> 2144

<211> 9

<212>PRT

<213> Mus musculus

<400> 2144

His Ala Glu Pro Leu Phe Tyr Leu Leu

15

<210> 2145

<211> 9

<212>PRT

<213> Mus musculus

<400> 2145

His Met Ala Ser Leu Ser Val Tyr Leu

15

<210> 2146

<211> 9

<212>PRT

<213> Mus musculus

<400> 2146

Ile Tyr Phe Pro Leu Trp Phe Gln Leu

15

<210> 2147

<211> 9

<212>PRT

<213> Mus musculus

<400> 2147

Ile Tyr Pro Asn His Ser Ser Pro Cys

15

<210> 2148

<211> 22

<212>PRT

<213> Homo sapiens

<400> 2148

Lys Gly Thr Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu

1 5 10 15

Ala Glu Tyr Leu Tyr Asn

20

<210> 2149

<211> 9

<212>PRT

<213> Mus musculus

<400> 2149

Lys Ile Pro Thr His Ala Glu Pro Leu

15

<210> 2150

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2150

Lys Thr Gly His Pro Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp

1 5 10 15

Met Val Gly Leu

20

<210> 2151

<211> 9

<212>PRT

<213> Mus musculus

<400> 2151

Lys Trp Cys Ala Asn Pro Asp Trp Ile

15

<210> 2152

<211> 22

<212>PRT

<213> Homo sapiens

<400> 2152

Leu Ala Phe Leu Gln Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val

1 5 10 15

Lys Ser Phe Asp Arg Ser

20

<210> 2153

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2153

Leu Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr

1 5 10 15

Ala Gly Thr Thr

20

<210> 2154

<211> 9

<212>PRT

<213> Mus musculus

<400> 2154

Leu Gly Phe Ala Ile Asn Ser Glu Met

15

<210> 2155

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2155

Leu Leu Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln

1 5 10 15

Pro Pro Arg Ala

20

<210> 2156

<211> 9

<212>PRT

<213> Mus musculus

<400> 2156

Leu Arg Leu Phe Gly Ile Asp Leu Leu

15

<210> 2157

<211> 9

<212>PRT

<213> Mus musculus

<400> 2157

Leu Ser Phe Cys Lys Ser Ala Ser Ile

15

<210> 2158

<211> 9

<212>PRT

<213> Mus musculus

<400> 2158

Leu Ser Val Tyr Leu Lys Thr Asn Val

15

<210> 2159

<211> 9

<212>PRT

<213> Mus musculus

<400> 2159

Leu Thr Ser Leu Thr Thr Met Gln Leu

15

<210> 2160

<211> 9

<212>PRT

<213> Mus musculus

<400> 2160

Met Gln Leu Tyr Arg Phe Ile Lys Ile

15

<210> 2161

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2161

Met Tyr Glu Leu Leu Gln Pro Ala Ala Ile Val

1 5 10

<210> 2162

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2162

Asn Leu Phe Leu Phe Leu Phe Ala Val

15

<210> 2163

<211> 9

<212>PRT

<213> Mus musculus

<400> 2163

Asn Gln Asn Val Gly Thr Lys Met Ile

15

<210> 2164

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2164

Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala

1 5 10 15

Phe Thr Ser Glu

20

<210> 2165

<211> 14

<212>PRT

<213> Mus musculus

<400> 2165

Pro Ser Leu Trp Glu Ile Glu Phe Ala Lys Gln Leu Ala Ser

1 5 10

<210> 2166

<211> 9

<212>PRT

<213> Mus musculus

<400> 2166

Gln Leu Asn Gln Asn Val Gly Thr Lys

15

<210> 2167

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2167

Gln Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys

1 5 10 15

His Tyr Asp Leu

20

<210> 2168

<211> 9

<212>PRT

<213> Mus musculus

<400> 2168

Arg Phe Ile Lys Ile Pro Thr His Ala

15

<210> 2169

<211> 9

<212>PRT

<213> Mus musculus

<400> 2169

Arg Met Glu Glu Ser Ser Val Thr Leu

15

<210> 2170

<211> 9

<212>PRT

<213> Mus musculus

<400> 2170

Ser Phe Cys Lys Ser Ala Ser Ile Pro

15

<210> 2171

<211> 9

<212>PRT

<213> Mus musculus

<400> 2171

Ser Phe Leu Trp Ser Val Phe Trp Leu

15

<210> 2172

<211> 9

<212>PRT

<213> Mus musculus

<400> 2172

Ser Arg Met Glu Glu Ser Ser Val Thr

15

<210> 2173

<211> 9

<212>PRT

<213> Mus musculus

<400> 2173

Ser Arg Val Phe Ile Ala Thr His Phe

15

<210> 2174

<211> 9

<212>PRT

<213> Mus musculus

<400> 2174

Thr His Ala Glu Pro Leu Phe Tyr Leu

15

<210> 2175

<211> 9

<212>PRT

<213> Mus musculus

<400> 2175

Thr His Phe Pro His Gln Val Ile Leu

15

<210> 2176

<211> 9

<212>PRT

<213> Mus musculus

<400> 2176

Thr Ser Leu Thr Thr Met Gln Leu Tyr

15

<210> 2177

<211> 9

<212>PRT

<213> Mus musculus

<400> 2177

Thr Tyr Tyr Gly Phe Leu Asn Phe Met

15

<210> 2178

<211> 30

<212>PRT

<213> Homo sapiens

<400> 2178

Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg Glu

1 5 10 15

Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly

20 25 30

<210> 2179

<211> 9

<212>PRT

<213> Mus musculus

<400> 2179

Val Phe Trp Leu Ile Gln Ile Ser Val

15

<210> 2180

<211> 9

<212>PRT

<213> Mus musculus

<400> 2180

Tyr Leu Lys Thr Asn Val Phe Leu Phe

15

<210> 2181

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2181

Tyr Leu Leu Leu Arg Val Leu Asn Ile

15

<210> 2182

<211> 9

<212>PRT

<213> Mus musculus

<400> 2182

Tyr Pro Asn His Ser Ser Pro Cys Leu

15

<210> 2183

<211> 9

<212>PRT

<213> Mus musculus

<400> 2183

Tyr Thr Ile Ser Arg Met Glu Glu Ser

15

<210> 2184

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2184

Tyr Val Arg Pro Leu Trp Val Arg Met Glu

1 5 10

<210> 2185

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2185

Ala Leu Trp Met Arg Leu Leu Pro Leu Leu

1 5 10

<210> 2186

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2186

Asp Trp Ile His Ile Asp Thr Thr Pro Phe Ala Gly Leu

1 5 10

<210> 2187

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2187

Glu Trp Val His Ile Asp Thr Thr Pro Phe Ala Ser Leu

1 5 10

<210> 2188

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2188

Phe Tyr Thr Pro Lys Thr Arg Arg Glu

15

<210> 2189

<211> 8

<212>PRT

<213> Homo sapiens

<400> 2189

Gly Glu Arg Gly Phe Phe Tyr Thr

15

<210> 2190

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2190

Leu Pro Leu Leu Ala Leu Leu Ala Leu

15

<210> 2191

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2191

Leu Trp Met Arg Leu Leu Pro Leu Leu

15

<210> 2192

<211> 5

<212>PRT

<213> Homo sapiens

<400> 2192

Pro Ala Glu Gly Thr

15

<210> 2193

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2193

Gln His Leu Gln Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe

1 5 10

<210> 2194

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2194

Arg Val Leu Asn Ile Asp Leu Leu Trp Ser Val Pro Ile

1 5 10

<210> 2195

<211> 31

<212>PRT

<213> Homo sapiens

<400> 2195

Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln

1 5 10 15

Thr Gln Glu Thr Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp

20 25 30

<210> 2196

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2196

Trp Met Arg Leu Leu Pro Leu Leu Ala Leu

1 5 10

<210> 2197

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2197

Tyr Thr Phe Leu Asn Phe Met Ser Asn Val Gly Asp Pro

1 5 10

<210> 2198

<211> 979

<212>PRT

<213> Homo sapiens

<400> 2198

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu

1 5 10 15

Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys

20 25 30

Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser

35 40 45

His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val

50 55 60

Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu

65 70 75 80

Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser

85 90 95

Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg

100 105 110

Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly

115 120 125

Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp

130 135 140

Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro

145 150 155 160

Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu

165 170 175

Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro

180 185 190

Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro

195 200 205

Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu

210 215 220

Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala

225 230 235 240

Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His

245 250 255

Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu

260 265 270

Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro

275 280 285

Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg

290 295 300

Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg

305 310 315 320

Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln

325 330 335

Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu

340 345 350

Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro

355 360 365

Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp

370 375 380

Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu

385 390 395 400

Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro

405 410 415

Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro

420 425 430

Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys

435 440 445

Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala

450 455 460

Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro

465 470 475 480

Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His

485 490 495

Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro

500 505 510

Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala

515 520 525

Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln

530 535 540

Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala

545 550 555 560

Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser

565 570 575

Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val

580 585 590

Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp

595 600 605

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

610 615 620

Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser

625 630 635 640

Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser

645 650 655

Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His

660 665 670

Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp

675 680 685

Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg

690 695 700

Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln

705 710 715 720

Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys

725 730 735

Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys

740 745 750

Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser

755 760 765

Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln

770 775 780

Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu

785 790 795 800

Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly

805 810 815

Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr

820 825 830

His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp

835 840 845

Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr

850 855 860

Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr

865 870 875 880

Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys

885 890 895

Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly

900 905 910

Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg

915 920 925

Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His

930 935 940

Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu

945 950 955 960

Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala

965 970 975

Leu Pro Gln

<210> 2199

<211> 15

<212>PRT

<213> Mus musculus

<400> 2199

Ala Glu Leu Asn Gln Leu Arg Ala Lys Glu Pro Thr Lys Leu Ala

1 5 10 15

<210> 2200

<211> 15

<212>PRT

<213> Mus musculus

<400> 2200

Glu Leu Arg Glu Leu Arg Leu Arg Leu Asp Gln Leu Thr Ala Asn

1 5 10 15

<210> 2201

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2201

Glu Arg Gly Phe Phe Tyr Thr Pro Lys

15

<210> 2202

<211> 7

<212>PRT

<213> Mus musculus

<400> 2202

Gly Leu Ala Pro Ser Gly Ala

15

<210> 2203

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2203

Leu Cys Gly Ser His Leu Val Glu Ala Leu

1 5 10

<210> 2204

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2204

Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr

1 5 10

<210> 2205

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2205

Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe

1 5 10

<210> 2206

<211> 15

<212>PRT

<213> Mus musculus

<400> 2206

Gln Val His Val Glu Met Asp Val Ala Lys Pro Asp Leu Thr Ala

1 5 10 15

<210> 2207

<211> 9

<212>PRT

<213> Mus musculus

<400> 2207

Trp Tyr Arg Ser Lys Phe Ala Asp Leu

15

<210> 2208

<211> 13

<212>PRT

<213> Bos taurus

<400> 2208

Phe Lys Ala Asp Glu Lys Lys Phe Trp Gly Lys Tyr Leu

1 5 10

<210> 2209

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2209

Gln Met Arg Pro Val Ser Arg Val Leu

15

<210> 2210

<211> 5

<212>PRT

<213> Bos taurus

<400> 2210

Ala Asp Glu Lys Lys

15

<210> 2211

<211> 16

<212>PRT

<213> Bos taurus

<400> 2211

Ala Asp Glu Lys Lys Phe Trp Gly Lys Tyr Leu Tyr Glu Ile Ala Arg

1 5 10 15

<210> 2212

<211> 5

<212>PRT

<213> Bos taurus

<400> 2212

Glu Phe Lys Ala Asp

15

<210> 2213

<211> 6

<212>PRT

<213> Bos taurus

<400> 2213

Glu Phe Lys Ala Asp Glu

15

<210> 2214

<211> 8

<212>PRT

<213> Bos taurus

<400> 2214

Glu Phe Lys Ala Asp Glu Lys Lys

15

<210> 2215

<211> 6

<212>PRT

<213> Bos taurus

<400> 2215

Phe Lys Ala Asp Glu Lys

15

<210> 2216

<211> 9

<212>PRT

<213> Simian immunodeficiency virus

<400> 2216

Phe Tyr Cys Lys Met Asn Trp Phe Leu

15

<210> 2217

<211> 9

<212>PRT

<213> Aquifex aeolicus

<400> 2217

Gly Phe Ile Lys Asn Phe Trp Phe Ile

15

<210> 2218

<211> 9

<212>PRT

<213> Helicobacter pylori

<400> 2218

Gly Tyr Asn Lys Ala Met Gly Phe Leu

15

<210> 2219

<211> 9

<212>PRT

<213> Helicobacter pylori

<400> 2219

Ile Phe Phe Lys Thr Ser Ser Phe Leu

15

<210> 2220

<211> 9

<212>PRT

<213> Saccharomyces cerevisiae

<400> 2220

Ile Tyr Gln Lys Ala Asn Thr Phe Leu

15

<210> 2221

<211> 9

<212>PRT

<213> Helicobacter pylori

<400> 2221

Ile Tyr Val Lys Thr Ser Ser Phe Leu

15

<210> 2222

<211> 6

<212>PRT

<213> Bos taurus

<400> 2222

Lys Ala Asp Glu Lys Lys

15

<210> 2223

<211> 9

<212>PRT

<213> Borrelia burgdorferi

<400> 2223

Lys Tyr Asn Lys Asn Gly Asn Phe Leu

15

<210> 2224

<211> 9

<212>PRT

<213> Haemophilus influenzae

<400> 2224

Lys Tyr Tyr Lys Asn Ser Gln Phe Leu

15

<210> 2225

<211> 9

<212>PRT

<213> Saccharomyces cerevisiae

<400> 2225

Lys Tyr Tyr Lys Thr Ser Asn Phe Leu

15

<210> 2226

<211> 18

<212>PRT

<213> Bos taurus

<400> 2226

Leu Pro Lys Leu Lys Pro Asp Pro Asn Thr Leu Cys Asp Glu Phe Lys

1 5 10 15

Ala Asp

<210> 2227

<211> 9

<212>PRT

<213> Borrelia burgdorferi 6

<400> 2227

Leu Tyr Ser Lys Asn Leu Val Phe Leu

15

<210> 2228

<211> 9

<212>PRT

<213> Methanothermobacter thermoautotrophicus

<400> 2228

Asn Phe Met Lys Thr Ala Gly Phe Ile

15

<210> 2229

<211> 9

<212>PRT

<213> Rickettsia prowazekii

<400> 2229

Gln Tyr Asn Lys Thr Gly Tyr Phe Ile

15

<210> 2230

<211> 9

<212>PRT

<213> Langat Virus

<400> 2230

Arg Phe Ser Lys Ala Leu Tyr Phe Leu

15

<210> 2231

<211> 9

<212>PRT

<213> Escherichia coli

<400> 2231

Arg Tyr Gln Lys Ala Gly Val Met Leu

15

<210> 2232

<211> 9

<212>PRT

<213> Aquifex aeolicus

<400> 2232

Thr Tyr Leu Lys Asn Ala Gln Phe Val

15

<210> 2233

<211> 9

<212>PRT

<213> Drosophila melanogaster

<400> 2233

Val Tyr Val Lys Thr Ser Ser Phe Ile

15

<210> 2234

<211> 9

<212>PRT

<213> Haemophilus influenzae

<400> 2234

Tyr Phe Leu Lys Cys Gly Tyr Phe Leu

15

<210> 2235

<211> 9

<212>PRT

<213> Yellow netted virus thistle

<400> 2235

Tyr Tyr Asn Lys Ala Leu Ser Phe Ile

15

<210> 2236

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2236

His Gly Asp Thr Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met

1 5 10 15

Ala Thr Lys Ser Leu

20

<210> 2237

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2237

Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr Thr Phe

1 5 10 15

Glu Tyr Gln Asp Leu

20

<210> 2238

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2238

Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu Ala Ala Leu Gly

1 5 10 15

Pro Glu Gly Ala

20

<210> 2239

<211> 42

<212>PRT

<213> Homo sapiens

<400> 2239

Arg Gln His Ala Arg Gln Gln Asp Lys Glu Arg Leu Ala Ala Leu Gly

1 5 10 15

Pro Glu Gly Ala His Gly Asp Thr Thr Phe Glu Tyr Gln Asp Leu Cys

20 25 30

Arg Gln His Met Ala Thr Lys Ser Leu Phe

35 40

<210> 2240

<211> 16

<212>PRT

<213> Mus musculus

<400> 2240

Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys

1 5 10 15

<210> 2241

<211> 12

<212>PRT

<213> Bos taurus

<400> 2241

Glu Asp Lys Gly Ala Cys Leu Leu Pro Lys Ile Glu

1 5 10

<210> 2242

<211> 30

<212>PRT

<213> Homo sapiens

<400> 2242

Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile

1 5 10 15

Asp Phe Leu Ile Glu Glu Ile Glu Arg Leu Gly Gln Asp Leu

20 25 30

<210> 2243

<211> 41

<212>PRT

<213> Homo sapiens

<400> 2243

Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe Lys

1 5 10 15

Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu

20 25 30

Ile Ala Phe Thr Ser Glu His Ser His

35 40

<210> 2244

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2244

Leu Tyr Leu Val Cys Gly Glu Arg Leu

15

<210> 2245

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2245

Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp Gly Lys

1 5 10 15

Pro

<210> 2246

<211> 4

<212>PRT

<213> Homo sapiens

<400> 2246

Pro Gly Gly Ser

1

<210> 2247

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2247

Val Ile Lys Ala Arg Met Met Glu Tyr

15

<210> 2248

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2248

Tyr Ala Ile Glu Asn Tyr Leu Glu Leu

15

<210> 2249

<211> 585

<212>PRT

<213> Homo sapiens

<400> 2249

Met Ala Ser Pro Gly Ser Gly Phe Trp Ser Phe Gly Ser Glu Asp Gly

1 5 10 15

Ser Gly Asp Ser Glu Asn Pro Gly Thr Ala Arg Ala Trp Cys Gln Val

20 25 30

Ala Gln Lys Phe Thr Gly Gly Ile Gly Asn Lys Leu Cys Ala Leu Leu

35 40 45

Tyr Gly Asp Ala Glu Lys Pro Ala Glu Ser Gly Gly Ser Gln Pro Pro

50 55 60

Arg Ala Ala Ala Arg Lys Ala Ala Cys Ala Cys Asp Gln Lys Pro Cys

65 70 75 80

Ser Cys Ser Lys Val Asp Val Asn Tyr Ala Phe Leu His Ala Thr Asp

85 90 95

Leu Leu Pro Ala Cys Asp Gly Glu Arg Pro Thr Leu Ala Phe Leu Gln

100 105 110

Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg

115 120 125

Ser Thr Lys Val Ile Asp Phe His Tyr Pro Asn Glu Leu Leu Gln Glu

130 135 140

Tyr Asn Trp Glu Leu Ala Asp Gln Pro Gln Asn Leu Glu Glu Ile Leu

145 150 155 160

Met His Cys Gln Thr Thr Leu Lys Tyr Ala Ile Lys Thr Gly His Pro

165 170 175

Arg Tyr Phe Asn Gln Leu Ser Thr Gly Leu Asp Met Val Gly Leu Ala

180 185 190

Ala Asp Trp Leu Thr Ser Thr Ala Asn Thr Asn Met Phe Thr Tyr Glu

195 200 205

Ile Ala Pro Val Phe Val Leu Leu Glu Tyr Val Thr Leu Lys Lys Met

210 215 220

Arg Glu Ile Ile Gly Trp Pro Gly Gly Ser Gly Asp Gly Ile Phe Ser

225 230 235 240

Pro Gly Gly Ala Ile Ser Asn Met Tyr Ala Met Met Ile Ala Arg Phe

245 250 255

Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg

260 265 270

Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly

275 280 285

Ala Ala Ala Leu Gly Ile Gly Thr Asp Ser Val Ile Leu Ile Lys Cys

290 295 300

Asp Glu Arg Gly Lys Met Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu

305 310 315 320

Glu Ala Lys Gln Lys Gly Phe Val Pro Phe Leu Val Ser Ala Thr Ala

325 330 335

Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Leu Leu Ala Val Ala Asp

340 345 350

Ile Cys Lys Lys Tyr Lys Ile Trp Met His Val Asp Ala Ala Trp Gly

355 360 365

Gly Gly Leu Leu Met Ser Arg Lys His Lys Trp Lys Leu Ser Gly Val

370 375 380

Glu Arg Ala Asn Ser Val Thr Trp Asn Pro His Lys Met Met Gly Val

385 390 395 400

Pro Leu Gln Cys Ser Ala Leu Leu Val Arg Glu Glu Gly Leu Met Gln

405 410 415

Asn Cys Asn Gln Met His Ala Ser Tyr Leu Phe Gln Gln Asp Lys His

420 425 430

Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg

435 440 445

His Val Asp Val Phe Lys Leu Trp Leu Met Trp Arg Ala Lys Gly Thr

450 455 460

Thr Gly Phe Glu Ala His Val Asp Lys Cys Leu Glu Leu Ala Glu Tyr

465 470 475 480

Leu Tyr Asn Ile Ile Lys Asn Arg Glu Gly Tyr Glu Met Val Phe Asp

485 490 495

Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile Pro Pro Ser

500 505 510

Leu Arg Thr Leu Glu Asp Asn Glu Glu Arg Met Ser Arg Leu Ser Lys

515 520 525

Val Ala Pro Val Ile Lys Ala Arg Met Met Glu Tyr Gly Thr Thr Met

530 535 540

Val Ser Tyr Gln Pro Leu Gly Asp Lys Val Asn Phe Phe Arg Met Val

545 550 555 560

Ile Ser Asn Pro Ala Ala Thr His Gln Asp Ile Asp Phe Leu Ile Glu

565 570 575

Glu Ile Glu Arg Leu Gly Gln Asp Leu

580 585

<210> 2250

<211> 12

<212>PRT

<213> Mus musculus

<400> 2250

Leu Tyr Phe Cys Ala Ala Arg Ser Asn Tyr Gln Leu

1 5 10

<210> 2251

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2251

Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser

1 5 10 15

<210> 2252

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2252

Gly Glu Ala Leu Ser Thr Leu Val Leu Asn Arg Leu Lys Val Gly

1 5 10 15

<210> 2253

<211> 15

<212>PRT

<213> Mycobacterium

<400> 2253

Gly Glu Ala Leu Ser Thr Leu Val Val Asn Lys Ile Arg Gly Thr

1 5 10 15

<210> 2254

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2254

Ala Leu Trp Gly Pro Asp Pro Ala Ala Ala Phe

1 5 10

<210> 2255

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2255

Leu Ala Leu Trp Gly Pro Asp Pro Ala Ala

1 5 10

<210> 2256

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2256

Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu

1 5 10

<210> 2257

<211> 42

<212>PRT

<213> Homo sapiens

<400> 2257

Ile Ala Ala Thr Leu Glu His Val Arg Asp Gln Arg Pro Gly Leu Val

1 5 10 15

Arg Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu

20 25 30

Val Asn Ala Ile Leu Lys Ala Leu Pro Gln

35 40

<210> 2258

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2258

Asn Leu Ala Gln Asp Leu Ala Thr Val

15

<210> 2259

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2259

Gln Leu Ala Arg Gln Gln Val His Val

15

<210> 2260

<211> 979

<212>PRT

<213> Homo sapiens

<400> 2260

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu

1 5 10 15

Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys

20 25 30

Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser

35 40 45

His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val

50 55 60

Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu

65 70 75 80

Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser

85 90 95

Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg

100 105 110

Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly

115 120 125

Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp

130 135 140

Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro

145 150 155 160

Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu

165 170 175

Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro

180 185 190

Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro

195 200 205

Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu

210 215 220

Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala

225 230 235 240

Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His

245 250 255

Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu

260 265 270

Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro

275 280 285

Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg

290 295 300

Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg

305 310 315 320

Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln

325 330 335

Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu

340 345 350

Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro

355 360 365

Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp

370 375 380

Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu

385 390 395 400

Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro

405 410 415

Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro

420 425 430

Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys

435 440 445

Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala

450 455 460

Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro

465 470 475 480

Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His

485 490 495

Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro

500 505 510

Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala

515 520 525

Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln

530 535 540

Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala

545 550 555 560

Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser

565 570 575

Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val

580 585 590

Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp

595 600 605

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

610 615 620

Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser

625 630 635 640

Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser

645 650 655

Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His

660 665 670

Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp

675 680 685

Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg

690 695 700

Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln

705 710 715 720

Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys

725 730 735

Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys

740 745 750

Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser

755 760 765

Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln

770 775 780

Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu

785 790 795 800

Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly

805 810 815

Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr

820 825 830

His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp

835 840 845

Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr

850 855 860

Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr

865 870 875 880

Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys

885 890 895

Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly

900 905 910

Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg

915 920 925

Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His

930 935 940

Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu

945 950 955 960

Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala

965 970 975

Leu Pro Gln

<210> 2261

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2261

Glu Trp Leu Lys Val Lys Ile Leu Pro Glu Val Lys

1 5 10

<210> 2262

<211> 20

<212>PRT

<213> Enterovirus A

<400> 2262

Trp Leu Lys Val Lys Ile Leu Pro Glu Val Lys Glu Lys His Glu Phe

1 5 10 15

Leu Asn Arg Leu

20

<210> 2263

<211> 15

<212>PRT

<213> Human endogenous retrovirus

<400> 2263

Gly Lys Thr Cys Pro Lys Glu Ile Pro Lys Gly Ser Lys Asn Thr

1 5 10 15

<210> 2264

<211> 23

<212>PRT

<213> Homo sapiens

<400> 2264

Ala Arg Phe Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala

1 5 10 15

Leu Pro Arg Leu Ile Ala Phe

20

<210> 2265

<211> 23

<212>PRT

<213> Human Coxsackievirus

<400> 2265

Leu Lys Val Lys Ile Leu Pro Glu Val Lys Glu Lys His Glu Phe Leu

1 5 10 15

Ser Arg Leu Lys Gln Leu Pro

20

<210> 2266

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2266

Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Ala

1 5 10

<210> 2267

<211> 13

<212>PRT

<213> Mus musculus

<400> 2267

Tyr Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala

1 5 10

<210> 2268

<211> 13

<212>PRT

<213> Mus musculus

<400> 2268

Tyr Lys Tyr Phe Pro Glu Val Lys Thr Lys Gly Met Ala

1 5 10

<210> 2269

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2269

Ala Arg Lys Val Lys Gly Ala Ala Gly

15

<210> 2270

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2270

Ala Arg Leu Ser Val Val Arg Asn Gly

15

<210> 2271

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2271

Asp Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr

1 5 10 15

His Gln Asp Ile Asp

20

<210> 2272

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2272

Phe Arg Lys Ala Asp Lys Phe Pro Met

15

<210> 2273

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2273

Phe Arg Lys Thr Ser Ile Ser Gly Ala

15

<210> 2274

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2274

Phe Arg Lys Thr Ser Lys Gly Gly Ser

15

<210> 2275

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2275

Gly Gly Thr Thr Thr Pro Arg Thr Thr

15

<210> 2276

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2276

Gly Arg Lys Ser Ala Val Ser Pro Ala

15

<210> 2277

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2277

His Lys Lys Ser Leu Ser Ser Pro Ser

15

<210> 2278

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2278

His Arg Lys Ser Thr Val Ala Gly Ser

15

<210> 2279

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2279

Lys Gly Lys Lys Ala Leu Gln Ser Ala

15

<210> 2280

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2280

Lys Lys Lys Lys Tyr Ala Glu Ala Val

15

<210> 2281

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2281

Lys Lys Thr Lys Gly Leu Val Thr Thr

15

<210> 2282

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2282

Lys Arg Arg Ala Ser Ala Gly Gly Pro

15

<210> 2283

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2283

Lys Ser Val Lys Pro Arg Gln Ala Thr

15

<210> 2284

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2284

Leu Arg Lys Lys Gly Tyr Asp Pro Gly

15

<210> 2285

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2285

Leu Ser Arg Lys Lys Thr Leu Thr Thr

15

<210> 2286

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2286

Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu

1 5 10

<210> 2287

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2287

Met Arg Lys Ala Asn Ser Pro Pro Thr

15

<210> 2288

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2288

Met Arg Lys Ser Thr Gly Thr Ala Ser

15

<210> 2289

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2289

Asn Arg Lys Leu Lys Ser Asn Met Met

15

<210> 2290

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2290

Asn Arg Arg Leu Leu Pro Met Pro Glu

15

<210> 2291

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2291

Gln Lys Lys Met Val Ala Leu Ser Gly

15

<210> 2292

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2292

Gln Lys Arg Ala Lys Gly Leu Ser Ala

15

<210> 2293

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2293

Arg Gly Leu Lys Ser Lys Ile Ala Met

15

<210> 2294

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2294

Arg Lys Lys Lys Pro Pro Gly Leu Ala

15

<210> 2295

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2295

Arg Lys Leu Ala His Pro Gly Thr Ser

15

<210> 2296

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2296

Arg Lys Arg Thr Arg His Leu Glu Gly

15

<210> 2297

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2297

Arg Lys Thr Ala Leu Gly Thr Arg Gln

15

<210> 2298

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2298

Arg Lys Val Val Gln Thr Ser Leu Glu

15

<210> 2299

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2299

Arg Arg Lys Leu Arg Thr Asn Ala Gly

15

<210> 2300

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2300

Arg Arg Lys Pro Gly Thr Glu Gln Leu

15

<210> 2301

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2301

Arg Ser Leu Lys Thr Lys Leu Pro Ser

15

<210> 2302

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2302

Ser Arg Lys Ala Thr Ala Ser Leu Pro

15

<210> 2303

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2303

Ser Arg Lys Lys Thr Phe Thr Gly Ala

15

<210> 2304

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2304

Ser Arg Lys Ser Gly Ser Leu Thr Lys

15

<210> 2305

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2305

Ser Arg Lys Val Ala Leu Gln Gly Gly

15

<210> 2306

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2306

Thr Lys Leu Ser Asn Thr Pro Ser Pro

15

<210> 2307

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2307

Thr Gln Asp Leu Gly Tyr Ser Arg Val

15

<210> 2308

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2308

Thr Arg Gly Leu Lys Gly Ala Pro Gln

15

<210> 2309

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2309

Thr Arg Lys Ala Leu Thr Gln Asn Thr

15

<210> 2310

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2310

Val Phe Asp Gly Lys Pro Gln His Thr Asn Val Cys Phe Trp Tyr Ile

1 5 10 15

Pro Pro Ser Leu

20

<210> 2311

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2311

Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His Gln

1 5 10 15

Asp Ile Asp Phe

20

<210> 2312

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2312

Val Arg Lys Leu Thr Val Thr Ser Ala

15

<210> 2313

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2313

Tyr Lys Lys Gly Ala Arg Pro Ile Gln

15

<210> 2314

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2314

Tyr Arg Lys Lys Ser Ser Ala Glu Leu

15

<210> 2315

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2315

Tyr Arg Lys Thr Ala Lys Glu Gly Thr

15

<210> 2316

<211> 29

<212>PRT

<213> Rubella virus

<400> 2316

Glu Ala Cys Val Thr Ser Trp Leu Trp Ser Glu Gly Glu Gly Ala Val

1 5 10 15

Phe Tyr Arg Val Asp Leu His Phe Ile Asn Leu Gly Thr

20 25

<210> 2317

<211> 21

<212>PRT

<213> Rubella virus

<400> 2317

Met Asp Phe Trp Cys Val Glu His Asp Arg Pro Pro Pro Ala Thr Pro

1 5 10 15

Thr Ser Leu Thr Thr

20

<210> 2318

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2318

Asn Met Phe Thr Tyr Glu Ile Ala Pro Val Phe Val Leu Met Glu

1 5 10 15

<210> 2319

<211> 25

<212>PRT

<213> Rubella virus

<400> 2319

Pro Phe Leu Gly His Asp Gly His His Gly Gly Thr Leu Arg Val Gly

1 5 10 15

Gln His His Arg Asn Ala Ser Asp Val

20 25

<210> 2320

<211> 21

<212>PRT

<213> Rubella virus

<400> 2320

Arg Val Lys Phe His Thr Glu Thr Arg Thr Val Trp Gln Leu Ser Val

1 5 10 15

Ala Gly Val Ser Cys

20

<210> 2321

<211> 16

<212>PRT

<213> Human Coxsackievirus

<400> 2321

Lys Ile Leu Pro Glu Val Lys Glu Lys His Glu Phe Leu Ser Arg Leu

1 5 10 15

<210> 2322

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2322

Lys Met Phe Pro Glu Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg

1 5 10 15

Leu

<210> 2323

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2323

Lys Tyr Phe Pro Glu Val Lys Thr Lys Gly Met Ala Ala Val Pro Lys

1 5 10 15

Leu

<210> 2324

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2324

Lys Arg Ser Arg Leu Asp Val

15

<210> 2325

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2325

Leu Gly Arg Gly Gly Ser Lys

15

<210> 2326

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2326

Arg Leu Gly Lys Arg Asp Ser

15

<210> 2327

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2327

Arg Gln Leu Gly Arg Gly Ser

15

<210> 2328

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2328

Ser Thr Val Gln Asp Cys Val

15

<210> 2329

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2329

Tyr Leu Gly Arg Gly Asp Lys

15

<210> 2330

<211> 12

<212>PRT

<213> Photobacterium phosphoreum

<400> 2330

Ala Lys Val Ala Ile Val Ile Ala Arg Phe Asn Ser

1 5 10

<210> 2331

<211> 12

<212>PRT

<213> Human herpes virus

<400> 2331

Gly Gly Val Ala Val Val Ile Gly Arg Phe Phe Gly

1 5 10

<210> 2332

<211> 12

<212>PRT

<213> Synechocystis species

<400> 2332

Ser Ala Ile Gly Ile Tyr Leu Gly Arg Phe Leu Arg

1 5 10

<210> 2333

<211> 10

<212>PRT

<213> Mus musculus

<400> 2333

His Leu Cys Gly Pro His Leu Val Glu Ala

1 5 10

<210> 2334

<211> 9

<212>PRT

<213> Mus musculus

<400> 2334

Ile Val Asp Gln Cys Cys Thr Ser Ile

15

<210> 2335

<211> 9

<212>PRT

<213> Mus musculus

<400> 2335

Leu Leu Val His Phe Leu Pro Leu Leu

15

<210> 2336

<211> 13

<212>PRT

<213> Streptococcus pneumoniae

<400> 2336

Asp Asp Ile Met Met Ser Tyr Ala Ala Lys Gly Phe Val

1 5 10

<210> 2337

<211> 13

<212>PRT

<213> Rickettsia prowazekii

<400> 2337

Glu Leu Val Leu Met Ser Tyr Arg Asp Lys Leu Val Leu

1 5 10

<210> 2338

<211> 13

<212>PRT

<213> Human herpes virus

<400> 2338

Lys Glu Leu Leu Gln Ser Tyr Val Ser Lys Asn Asn Asn

1 5 10

<210> 2339

<211> 13

<212>PRT

<213> Legionella pneumophila

<400> 2339

Lys Met Ser Leu Leu Gln Tyr Ile Val Lys Asn Lys Ile

1 5 10

<210> 2340

<211> 13

<212>PRT

<213> Lactococcus lactis

<400> 2340

Leu Val Ile Leu Pro Met Phe His Val Ser Gly Leu Ser

1 5 10

<210> 2341

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2341

Pro Ile Ile Leu Pro Leu Trp His Val Gly Glu Pro Gly

1 5 10

<210> 2342

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2342

Pro Ile Ile Leu Pro Leu Trp His Val Gly Met Asn Asp

1 5 10

<210> 2343

<211> 13

<212>PRT

<213> Neisseria meningitidis

<400> 2343

Pro Val Ile Leu Pro Gln Trp Gln Ser Leu Gly Asn Arg

1 5 10

<210> 2344

<211> 13

<212>PRT

<213> Staphylococcus aureus

<400> 2344

Pro Tyr Val Leu Leu Ala Tyr Ile Val Lys Ser Val Gly

1 5 10

<210> 2345

<211> 13

<212>PRT

<213> Chlamydia pneumoniae

<400> 2345

Gln Ala Met Asn Ile Leu Tyr Gln Thr Val Gln Ala Phe

1 5 10

<210> 2346

<211> 13

<212>PRT

<213> Streptococcus pyogenes

<400> 2346

Arg Glu Ile Leu Pro Gln Tyr Gln Leu Val Ile Leu Ala

1 5 10

<210> 2347

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2347

Thr Thr Leu Leu Pro Gln Trp Arg Val Ser Ala Phe Val

1 5 10

<210> 2348

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2348

Ala Tyr Ala Lys Asp Val Lys Phe Gly Ala Asp Ala

1 5 10

<210> 2349

<211> 13

<212>PRT

<213> Mus musculus

<400> 2349

Leu Ser Lys Val Ala Pro Val Ile Lys Ala Arg Met Met

1 5 10

<210> 2350

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2350

Ser Arg Leu Gly Leu Trp Val Arg Met Glu

1 5 10

<210> 2351

<211> 14

<212>PRT

<213> Mus musculus

<400> 2351

Trp Ser Arg Met Asp Gln Leu Ala Lys Glu Leu Thr Ala Glu

1 5 10

<210> 2352

<211> 18

<212>PRT

<213> Mus musculus

<400> 2352

Phe Leu Pro Leu Leu Ala Leu Leu Ala Leu Trp Glu Pro Lys Pro Thr

1 5 10 15

Gln Ala

<210> 2353

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2353

Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly

1 5 10 15

Ser Leu Gln Lys

20

<210> 2354

<211> 24

<212>PRT

<213> Homo sapiens

<400> 2354

Lys Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala

1 5 10 15

Ser Pro Ile Ile Glu His Asp Pro

20

<210> 2355

<211> 28

<212>PRT

<213> Homo sapiens

<400> 2355

Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln Ala Glu Pro Asn

1 5 10 15

Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys

20 25

<210> 2356

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2356

Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr Arg Thr Leu Thr

1 5 10 15

Gln Phe His Phe

20

<210> 2357

<211> 22

<212>PRT

<213> Homo sapiens

<400> 2357

Ser Lys Asp Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val

1 5 10 15

Asn Ala Ile Leu Lys Ala

20

<210> 2358

<211> 29

<212>PRT

<213> Homo sapiens

<400> 2358

Ser Arg Val Ser Ser Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala

1 5 10 15

Ser Pro Ser Ser His Ser Ser Thr Pro Ser Trp Cys Glu

20 25

<210> 2359

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2359

Ala Phe Leu Gln Asp Val Met Asn Ile Leu Leu Gln

1 5 10

<210> 2360

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2360

Ala Leu Leu Arg Cys Ile Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn

1 5 10 15

Glu Asp Cys

<210> 2361

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2361

Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu

1 5 10

<210> 2362

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2362

Ala Thr Cys Arg Phe Tyr Thr Leu Asp Ser Ile Lys

1 5 10

<210> 2363

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2363

Asp Ile Asn Thr Val Thr Thr Val Ala Gln Ser Arg

1 5 10

<210> 2364

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2364

Asp Arg Val Arg Ser Ile Thr Leu Gly Asn Ser Thr

1 5 10

<210> 2365

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2365

Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala Asn

1 5 10

<210> 2366

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2366

Glu Thr Ser Leu Ser Ala Ala Gly Asn Ser Ile Ile

1 5 10

<210> 2367

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2367

Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr

1 5 10

<210> 2368

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2368

Gly Ala Asp Ile Lys Lys Thr Met Glu Gly Pro Val

1 5 10

<210> 2369

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2369

Gly Val Glu Leu Arg Gln Leu Thr Pro Glu Gln Leu

1 5 10

<210> 2370

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2370

Lys Asp Val Lys Phe Gly Ala Asp Ala Arg Ala Leu

1 5 10

<210> 2371

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2371

Lys Glu Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Cys

1 5 10 15

<210> 2372

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2372

Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu Gln

1 5 10

<210> 2373

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2373

Lys Thr Gly His Pro Arg Tyr Phe Asn Gln Leu Ser

1 5 10

<210> 2374

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2374

Leu Leu Glu Ser Gln Ile Ala Thr Ile Glu Gln Thr

1 5 10

<210> 2375

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2375

Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg Ser

1 5 10

<210> 2376

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2376

Leu Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser

1 5 10

<210> 2377

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2377

Leu Arg Gln Leu Thr Pro Glu Gln Leu Ser Thr Leu

1 5 10

<210> 2378

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2378

Leu Thr Ala Val Glu Thr Gly His Thr Ser Gln Val

1 5 10

<210> 2379

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2379

Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe Gly

1 5 10

<210> 2380

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2380

Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly Leu

1 5 10

<210> 2381

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2381

Pro Arg Pro Arg Asp Arg Ser Gly Leu Ala Pro Lys

1 5 10

<210> 2382

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2382

Pro Ser Asn Ser Ala Ser Val Pro Ala Leu Thr Ala

1 5 10

<210> 2383

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2383

Pro Thr Leu Ala Phe Leu Gln Asp Val Met Asn Ile

1 5 10

<210> 2384

<211> 23

<212>PRT

<213> Human Coxsackievirus

<400> 2384

Pro Val Lys Asp Val Met Ile Lys Ser Leu Pro Ala Pro Ala Leu Asn

1 5 10 15

Ser Pro Thr Val Glu Glu Cys

20

<210> 2385

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2385

Arg Asp Arg Ser Gly Leu Ala Pro Lys Arg Pro Gly

1 5 10

<210> 2386

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2386

Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg

1 5 10

<210> 2387

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2387

Arg Ser Gly Pro Ser Asn Ser Ala Ser Val Pro Ala

1 5 10

<210> 2388

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2388

Arg Ser Ile Thr Leu Gly Asn Ser Thr Ile Thr Thr

1 5 10

<210> 2389

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2389

Arg Thr Ala Leu Leu Asp Ala Ala Gly Val Ala Ser

1 5 10

<210> 2390

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2390

Ser Ala Ser Val Pro Ala Leu Thr Ala Val Glu Thr

1 5 10

<210> 2391

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2391

Ser Gly Gly Leu Arg Leu Leu Leu Cys Leu Leu Leu

1 5 10

<210> 2392

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2392

Ser Gly Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly

1 5 10

<210> 2393

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2393

Ser Leu Glu Lys Lys Met Ser Asn Tyr Ile Gln Phe

1 5 10

<210> 2394

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2394

Ser Gln Ile Ala Thr Ile Glu Gln Thr Ala Pro Ser

1 5 10

<210> 2395

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2395

Thr Lys Gln Met Val Gln Met Arg Arg Lys Leu Glu

1 5 10

<210> 2396

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2396

Thr Arg Lys Asp Ile Asn Thr Val Thr Thr Val Ala

1 5 10

<210> 2397

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2397

Val Glu Thr Gly His Thr Ser Gln Val Thr Pro Ser

1 5 10

<210> 2398

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2398

Val Lys Glu Lys Gly Met Ala Ala Leu Pro Arg Leu

1 5 10

<210> 2399

<211> 17

<212>PRT

<213> Human Coxsackievirus

<400> 2399

Val Met Ile Lys Ser Leu Pro Ala Leu Asn Ser Pro Thr Val Glu Glu

1 5 10 15

Cys

<210> 2400

<211> 12

<212>PRT

<213> Human Coxsackievirus

<400> 2400

Val Pro Ala Leu Thr Ala Val Glu Thr Gly His Thr

1 5 10

<210> 2401

<211> 14

<212>PRT

<213> Mus musculus

<400> 2401

Glu Tyr Val Thr Leu Lys Lys Met Arg Glu Ile Ile Gly Trp

1 5 10

<210> 2402

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2402

Asp Val Met Asn Ile Leu Leu Gln Tyr Val Val Lys Ser Phe Asp Arg

1 5 10 15

Ser Thr Lys Val

20

<210> 2403

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2403

Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys

1 5 10 15

Arg Gly Ile Val

20

<210> 2404

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2404

Lys Asp Tyr Arg Ala Tyr Tyr Thr Phe Leu Asn Phe Met Ser Asn Val

1 5 10 15

Gly Asp Pro Arg

20

<210> 2405

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2405

Lys Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr His

1 5 10 15

Gln Asp Ile Asp

20

<210> 2406

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2406

Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu Lys Lys Gly

1 5 10 15

Ala Ala Ala Leu

20

<210> 2407

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2407

Arg Leu Gln Gln Leu Val Leu Asp Pro Gly Phe Leu Gly Leu Glu Pro

1 5 10 15

Leu Leu Asp Leu

20

<210> 2408

<211> 20

<212>PRT

<213> Porphyromonas gingivalis

<400> 2408

Thr Leu Val Val Asn Arg Leu Arg Gly Ser Leu Lys Ile Cys Ala Val

1 5 10 15

Lys Ala Pro Gly

20

<210> 2409

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2409

Ala His His Pro Ile Trp Ala Arg Met Asp Ala

1 5 10

<210> 2410

<211> 14

<212>PRT

<213> Mus musculus

<400> 2410

Asp Thr Lys Val Met Lys Cys Val Leu Glu Val Ile Ser Asp

1 5 10

<210> 2411

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2411

Asp Ser Val Ile Leu Ile Lys Cys Asp Glu Arg Gly Lys Met Ile Pro

1 5 10 15

Ser Asp Leu Glu

20

<210> 2412

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2412

His Lys Trp Lys Leu Ser Gly Val Glu Arg Ala Asn Ser Val Thr Trp

1 5 10 15

Asn Pro His Lys

20

<210> 2413

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2413

Lys Cys Leu Glu Leu Ala Glu Tyr Leu Tyr Asn Ile Ile Lys Asn Arg

1 5 10 15

Glu Gly Tyr Glu

20

<210> 2414

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2414

Lys Gly Met Ala Ala Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His

1 5 10 15

Ser His Phe Ser

20

<210> 2415

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2415

Arg Pro Thr Leu Ala Phe Leu Gln Asp Val Met Asn Ile Leu Leu Gln

1 5 10 15

Tyr Val Val Lys

20

<210> 2416

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2416

Tyr Asp Leu Ser Tyr Asp Thr Gly Asp Lys Ala Leu Gln Cys Gly Arg

1 5 10 15

His Val Asp Val

20

<210> 2417

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2417

Ile Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp

1 5 10

<210> 2418

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2418

Pro Thr Ile Ala Phe Leu Gln Asp Val Met Asn Ile Leu Leu Gln Tyr

1 5 10 15

Val Val Lys Ser

20

<210> 2419

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2419

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Glu Gly

1 5 10 15

<210> 2420

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2420

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Gly Glu Gly

1 5 10 15

<210> 2421

<211> 369

<212>PRT

<213> Homo sapiens

<400> 2421

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys

1 5 10 15

Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val

20 25 30

Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly

35 40 45

Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala

50 55 60

Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile

65 70 75 80

Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly

85 90 95

Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr

100 105 110

Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro

115 120 125

Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala

130 135 140

Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr

145 150 155 160

Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr

165 170 175

Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu

180 185 190

Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val

195 200 205

Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp

210 215 220

Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe

225 230 235 240

Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser

245 250 255

Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile

260 265 270

Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys

275 280 285

Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His

290 295 300

Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala

305 310 315 320

Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys

325 330 335

Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu

340 345 350

Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys

355 360 365

Asp

<210> 2422

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2422

Leu Pro Arg Leu Ile Ala Phe Thr Ser Glu His Ser His Phe Ser Leu

1 5 10 15

Lys Lys

<210> 2423

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2423

Val Asn Phe Phe Arg Met Val Ile Ser Asn Pro Ala Ala Thr

1 5 10

<210> 2424

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2424

Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys

1 5 10

<210> 2425

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2425

Pro Leu Leu Ala Leu Leu Ala Leu Trp Gly

1 5 10

<210> 2426

<211> 12

<212>PRT

<213> Mus musculus

<400> 2426

Ala Ser Ser Leu Gly Gly Asn Gln Asp Thr Gln Tyr

1 5 10

<210> 2427

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2427

Ala Leu Gly Asp Leu Phe Gln Ser Ile

15

<210> 2428

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2428

Ala Val Ala Ala Asn Ile Val Leu Thr Val

1 5 10

<210> 2429

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2429

Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu

1 5 10

<210> 2430

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2430

His Ile Ala Gly Ser Leu Ala Val Val

15

<210> 2431

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2431

Ile Leu Ala Val Asp Gly Val Leu Ser Val

1 5 10

<210> 2432

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2432

Ile Leu Lys Asp Phe Ser Ile Leu Leu

15

<210> 2433

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2433

Ile Leu Val Leu Ala Ser Thr Ile Thr Ile

1 5 10

<210> 2434

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2434

Leu Leu Ile Asp Leu Thr Ser Phe Leu

15

<210> 2435

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2435

Ser Ile Ser Val Leu Ile Ser Ala Leu

15

<210> 2436

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2436

Val Val Thr Gly Val Leu Val Tyr Leu

15

<210> 2437

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2437

Phe Ile Phe Ser Ile Leu Val Leu Ala

15

<210> 2438

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2438

Ile Gln Ala Thr Val Met Ile Ile Val

15

<210> 2439

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2439

Lys Met Tyr Ala Phe Thr Leu Glu Ser

15

<210> 2440

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2440

Lys Ser Leu Asn Tyr Ser Gly Val Lys

15

<210> 2441

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2441

Leu Leu Ser Ile Leu Cys Ile Trp Val

15

<210> 2442

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2442

Leu Leu Ser Leu Phe Ser Leu Trp Leu

15

<210> 2443

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2443

Met Ile Ile Val Ser Ser Cys Ala Val

15

<210> 2444

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2444

Arg Leu Leu Tyr Pro Asp Tyr Gln Ile

15

<210> 2445

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2445

Thr Met His Ser Leu Thr Ile Gln Met

15

<210> 2446

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2446

Val Ala Ala Asn Ile Val Leu Thr Val

15

<210> 2447

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2447

Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr Val

1 5 10 15

Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala

20 25

<210> 2448

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2448

Ala Lys Met His Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys

1 5 10 15

Pro Val Asn Lys Asp Gln Cys Pro Arg Glu Arg

20 25

<210> 2449

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2449

Ala Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala

1 5 10 15

Ile Cys Phe Ile Phe Met Ile Ala Glu Val Val

20 25

<210> 2450

<211> 34

<212>PRT

<213> Homo sapiens

<400> 2450

Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys Ala Leu

1 5 10 15

Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu Ser Pro

20 25 30

Val Asp

<210> 2451

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2451

Asp Gly Val Leu Ser Val His Ser Leu His Ile Trp Ser Leu Thr Met

1 5 10 15

Asn Gln Val Ile Leu Ser Ala His Val Ala Thr

20 25

<210> 2452

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2452

Glu Glu Leu Glu Ser Gly Gly Met Tyr His Cys His Ser Gly Ser Lys

1 5 10 15

Pro Thr Glu Lys Gly Ala Asn Glu Tyr Ala Tyr

20 25

<210> 2453

<211> 41

<212>PRT

<213> Homo sapiens

<400> 2453

Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala Leu Leu Ser Ile Leu

1 5 10 15

Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr Leu Ala Cys Glu Arg

20 25 30

Leu Leu Tyr Pro Asp Tyr Gln Ile Gln

35 40

<210> 2454

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2454

Phe Ile Phe Ser Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys

1 5 10 15

Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro

20 25

<210> 2455

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2455

Gly His Ile Ala Gly Ser Leu Ala Val Val Thr Asp Ala Ala His Leu

1 5 10 15

Leu Ile Asp Leu Thr Ser Phe Leu Leu Ser Leu

20 25

<210> 2456

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2456

His Leu Leu Ile Asp Leu Thr Ser Phe Leu Leu Ser Leu Phe Ser Leu

1 5 10 15

Trp Leu Ser Ser Lys Pro Pro Ser Lys Arg Leu

20 25

<210> 2457

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2457

His Gln Arg Cys Leu Gly His Asn His Lys Glu Val Gln Ala Asn Ala

1 5 10 15

Ser Val Arg Ala Ala Phe Val His Ala Leu Gly

20 25

<210> 2458

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2458

Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe

1 5 10 15

Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys

20 25

<210> 2459

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2459

Leu Lys Asp Phe Ser Ile Leu Leu Met Glu Gly Val Pro Lys Ser Leu

1 5 10 15

Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala

20 25

<210> 2460

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2460

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys

1 5 10 15

Met His Ala Phe Thr Leu Glu Ser Val Glu Leu

20 25

<210> 2461

<211> 26

<212>PRT

<213> Homo sapiens

<400> 2461

Met His Ser Leu Thr Ile Gln Met Glu Ser Pro Val Asp Gln Asp Pro

1 5 10 15

Asp Cys Leu Phe Cys Glu Asp Pro Cys Asp

20 25

<210> 2462

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2462

Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp Leu Phe

1 5 10 15

Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile

20 25

<210> 2463

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2463

Gln Lys Pro Val Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu

1 5 10 15

Leu Glu Ser Gly Gly Met Tyr His Cys His Ser

20 25

<210> 2464

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2464

Ser Ala Ile Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His

1 5 10 15

Ile Ala Gly Ser Leu Ala Val Val Thr Asp Ala

20 25

<210> 2465

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2465

Ser Cys Ala Val Ala Ala Asn Ile Val Leu Thr Val Val Leu His Gln

1 5 10 15

Arg Cys Leu Gly His Asn His Lys Glu Val Gln

20 25

<210> 2466

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2466

Ser Leu Asn Tyr Ser Gly Val Lys Glu Leu Ile Leu Ala Val Asp Gly

1 5 10 15

Val Leu Ser Val His Ser Leu His Ile Trp Ser

20 25

<210> 2467

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2467

Ser Leu Trp Leu Ser Ser Lys Pro Pro Ser Lys Arg Leu Thr Phe Gly

1 5 10 15

Trp His Arg Ala Glu Ile Leu Gly Ala Leu Leu

20 25

<210> 2468

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2468

Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala Thr Ala Ala Ser

1 5 10 15

Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala

20 25

<210> 2469

<211> 27

<212>PRT

<213> Homo sapiens

<400> 2469

Tyr Phe Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile

1 5 10 15

Phe Ser Ile Leu Val Leu Ala Ser Thr Ile Thr

20 25

<210> 2470

<211> 9

<212>PRT

<213> Mus musculus

<400> 2470

Ala Ile Asn Ser Glu Met Phe Leu Arg

15

<210> 2471

<211> 10

<212>PRT

<213> Mus musculus

<400> 2471

Leu Ala Leu Glu Val Ala Arg Gln Lys Arg

1 5 10

<210> 2472

<211> 10

<212>PRT

<213> Mus musculus

<400> 2472

Thr Leu Ala Leu Glu Val Ala Gln Gln Lys

1 5 10

<210> 2473

<211> 10

<212>PRT

<213> Mus musculus

<400> 2473

Thr Leu Ala Leu Glu Val Ala Arg Gln Lys

1 5 10

<210> 2474

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2474

Thr Leu Val Val Asn Lys Ile Arg Gly Thr Phe Lys Ser Val Ala Val

1 5 10 15

Lys Ala Pro Gly

20

<210> 2475

<211> 20

<212>PRT

<213> Chlamydia pneumoniae

<400> 2475

Thr Leu Val Val Asn Lys Leu Gln Gly Leu Leu Gln Val Thr Val Val

1 5 10 15

Thr Ile Pro Gln

20

<210> 2476

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2476

Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg Gln Tyr

1 5 10

<210> 2477

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2477

Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn

1 5 10

<210> 2478

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2478

Ala Cys Asp Gly Glu Arg Pro Thr Leu

15

<210> 2479

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2479

Ala His Val Asp Lys Cys Leu Glu Leu

15

<210> 2480

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2480

Ala Leu Trp Gly Pro Asp Pro Ala Ala Val

1 5 10

<210> 2481

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2481

Ala Pro Val Ile Lys Ala Arg Met Met

15

<210> 2482

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2482

Ala Gln Trp Gly Pro Asp Pro Ala Ala Val

1 5 10

<210> 2483

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2483

His Pro Arg Tyr Phe Asn Gln Leu Ser Thr

1 5 10

<210> 2484

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2484

Ile Pro Ser Asp Leu Glu Arg Arg Ile Leu

1 5 10

<210> 2485

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with diabetes

<400> 2485

Arg Gln Trp Gly Pro Asp Pro Ala Ala Val

1 5 10

<210> 2486

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2486

Ser Pro Gly Ser Gly Phe Trp Ser Phe

15

<210> 2487

<211> 1015

<212>PRT

<213> Homo sapiens

<400> 2487

Met Gly Pro Pro Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro

1 5 10 15

Pro Arg Val Leu Pro Ala Ala Pro Ser Ser Val Pro Arg Gly Arg Gln

20 25 30

Leu Pro Gly Arg Leu Gly Cys Leu Leu Glu Glu Gly Leu Cys Gly Ala

35 40 45

Ser Glu Ala Cys Val Asn Asp Gly Val Phe Gly Arg Cys Gln Lys Val

50 55 60

Pro Ala Met Asp Phe Tyr Arg Tyr Glu Val Ser Pro Val Ala Leu Gln

65 70 75 80

Arg Leu Arg Val Ala Leu Gln Lys Leu Ser Gly Thr Gly Phe Thr Trp

85 90 95

Gln Asp Asp Tyr Thr Gln Tyr Val Met Asp Gln Glu Leu Ala Asp Leu

100 105 110

Pro Lys Thr Tyr Leu Arg Arg Pro Glu Ala Ser Ser Pro Ala Arg Pro

115 120 125

Ser Lys His Ser Val Gly Ser Glu Arg Arg Tyr Ser Arg Glu Gly Gly

130 135 140

Ala Ala Leu Ala Asn Ala Leu Arg Arg His Leu Pro Phe Leu Glu Ala

145 150 155 160

Leu Ser Gln Ala Pro Ala Ser Asp Val Leu Ala Arg Thr His Thr Ala

165 170 175

Gln Asp Arg Pro Pro Ala Glu Gly Asp Asp Arg Phe Ser Glu Ser Ile

180 185 190

Leu Thr Tyr Val Ala His Thr Ser Ala Leu Thr Tyr Pro Pro Gly Ser

195 200 205

Arg Thr Gln Leu Arg Glu Asp Leu Leu Pro Arg Thr Leu Gly Gln Leu

210 215 220

Gln Pro Asp Glu Leu Ser Pro Lys Val Asp Ser Gly Val Asp Arg His

225 230 235 240

His Leu Met Ala Ala Leu Ser Ala Tyr Ala Ala Gln Arg Pro Pro Ala

245 250 255

Pro Pro Gly Glu Gly Ser Leu Glu Pro Gln Tyr Leu Leu Arg Ala Pro

260 265 270

Ser Arg Met Pro Arg Pro Leu Leu Ala Pro Ala Ala Pro Gln Lys Trp

275 280 285

Pro Ser Pro Leu Gly Asp Ser Glu Asp Pro Ser Ser Thr Gly Asp Gly

290 295 300

Ala Arg Ile His Thr Leu Leu Lys Asp Leu Gln Arg Gln Pro Ala Glu

305 310 315 320

Val Arg Gly Leu Ser Gly Leu Glu Leu Asp Gly Met Ala Glu Leu Met

325 330 335

Ala Gly Leu Met Gln Gly Val Asp His Gly Val Ala Arg Gly Ser Pro

340 345 350

Gly Arg Ala Ala Leu Gly Glu Ser Gly Glu Gln Ala Asp Gly Pro Lys

355 360 365

Ala Thr Leu Arg Gly Asp Ser Phe Pro Asp Asp Gly Val Gln Asp Asp

370 375 380

Asp Asp Arg Leu Tyr Gln Glu Val His Arg Leu Ser Ala Thr Leu Gly

385 390 395 400

Gly Leu Leu Gln Asp His Gly Ser Arg Leu Leu Pro Gly Ala Leu Pro

405 410 415

Phe Ala Arg Pro Leu Asp Met Glu Arg Lys Lys Ser Glu His Pro Glu

420 425 430

Ser Ser Leu Ser Ser Glu Glu Glu Thr Ala Gly Val Glu Asn Val Lys

435 440 445

Ser Gln Thr Tyr Ser Lys Asp Leu Leu Gly Gln Gln Pro His Ser Glu

450 455 460

Pro Gly Ala Ala Ala Phe Gly Glu Leu Gln Asn Gln Met Pro Gly Pro

465 470 475 480

Ser Lys Glu Glu Gln Ser Leu Pro Ala Gly Ala Gln Glu Ala Leu Ser

485 490 495

Asp Gly Leu Gln Leu Glu Val Gln Pro Ser Glu Glu Glu Ala Arg Gly

500 505 510

Tyr Ile Val Thr Asp Arg Asp Pro Leu Arg Pro Glu Glu Gly Arg Arg

515 520 525

Leu Val Glu Asp Val Ala Arg Leu Leu Gln Val Pro Ser Ser Ala Phe

530 535 540

Ala Asp Val Glu Val Leu Gly Pro Ala Val Thr Phe Lys Val Ser Ala

545 550 555 560

Asn Val Gln Asn Val Thr Thr Glu Asp Val Glu Lys Ala Thr Val Asp

565 570 575

Asn Lys Asp Lys Leu Glu Glu Thr Ser Gly Leu Lys Ile Leu Gln Thr

580 585 590

Gly Val Gly Ser Lys Ser Lys Leu Lys Phe Leu Pro Pro Gln Ala Glu

595 600 605

Gln Glu Asp Ser Thr Lys Phe Ile Ala Leu Thr Leu Val Ser Leu Ala

610 615 620

Cys Ile Leu Gly Val Leu Leu Ala Ser Gly Leu Ile Tyr Cys Leu Arg

625 630 635 640

His Ser Ser Gln His Arg Leu Lys Glu Lys Leu Ser Gly Leu Gly Gly

645 650 655

Asp Pro Gly Ala Asp Ala Thr Ala Ala Tyr Gln Glu Leu Cys Arg Gln

660 665 670

Arg Met Ala Thr Arg Pro Pro Asp Arg Pro Glu Gly Pro His Thr Ser

675 680 685

Arg Ile Ser Ser Val Ser Ser Gln Phe Ser Asp Gly Pro Ile Pro Ser

690 695 700

Pro Ser Ala Arg Ser Ser Ala Ser Ser Trp Ser Glu Glu Pro Val Gln

705 710 715 720

Ser Asn Met Asp Ile Ser Thr Gly His Met Ile Leu Ser Tyr Met Glu

725 730 735

Asp His Leu Lys Asn Lys Asn Arg Leu Glu Lys Glu Trp Glu Ala Leu

740 745 750

Cys Ala Tyr Gln Ala Glu Pro Asn Ser Ser Phe Val Ala Gln Arg Glu

755 760 765

Glu Asn Val Pro Lys Asn Arg Ser Leu Ala Val Leu Thr Tyr Asp His

770 775 780

Ser Arg Val Leu Leu Lys Ala Glu Asn Ser His Ser His Ser Asp Tyr

785 790 795 800

Ile Asn Ala Ser Pro Ile Met Asp His Asp Pro Arg Asn Pro Ala Tyr

805 810 815

Ile Ala Thr Gln Gly Pro Leu Pro Ala Thr Val Ala Asp Phe Trp Gln

820 825 830

Met Val Trp Glu Ser Gly Cys Val Val Ile Val Met Leu Thr Pro Leu

835 840 845

Ala Glu Asn Gly Val Arg Gln Cys Tyr His Tyr Trp Pro Asp Glu Gly

850 855 860

Ser Asn Leu Tyr His Ile Tyr Glu Val Asn Leu Val Ser Glu His Ile

865 870 875 880

Trp Cys Glu Asp Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Leu Gln

885 890 895

Thr Asn Glu Thr Arg Thr Val Thr Gln Phe His Phe Leu Ser Trp Tyr

900 905 910

Asp Arg Gly Val Pro Ser Ser Ser Arg Ser Leu Leu Asp Phe Arg Arg

915 920 925

Lys Val Asn Lys Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His

930 935 940

Cys Ser Asp Gly Ala Gly Arg Ser Gly Thr Tyr Val Leu Ile Asp Met

945 950 955 960

Val Leu Asn Lys Met Ala Lys Gly Ala Lys Glu Ile Asp Ile Ala Ala

965 970 975

Thr Leu Glu His Leu Arg Asp Gln Arg Pro Gly Met Val Gln Thr Lys

980 985 990

Glu Gln Phe Glu Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala

995 1000 1005

Ile Leu Lys Ala Leu Pro Gln

1010 1015

<210> 2488

<211> 979

<212>PRT

<213> Homo sapiens

<400> 2488

Met Arg Arg Pro Arg Arg Pro Gly Gly Leu Gly Gly Ser Gly Gly Leu

1 5 10 15

Arg Leu Leu Leu Cys Leu Leu Leu Leu Ser Ser Arg Pro Gly Gly Cys

20 25 30

Ser Ala Val Ser Ala His Gly Cys Leu Phe Asp Arg Arg Leu Cys Ser

35 40 45

His Leu Glu Val Cys Ile Gln Asp Gly Leu Phe Gly Gln Cys Gln Val

50 55 60

Gly Val Gly Gln Ala Arg Pro Leu Leu Gln Val Thr Ser Pro Val Leu

65 70 75 80

Gln Arg Leu Gln Gly Val Leu Arg Gln Leu Met Ser Gln Gly Leu Ser

85 90 95

Trp His Asp Asp Leu Thr Gln Tyr Val Ile Ser Gln Glu Met Glu Arg

100 105 110

Ile Pro Arg Leu Arg Pro Pro Glu Pro Arg Pro Arg Asp Arg Ser Gly

115 120 125

Leu Ala Pro Lys Arg Pro Gly Pro Ala Gly Glu Leu Leu Leu Gln Asp

130 135 140

Ile Pro Thr Gly Ser Ala Pro Ala Ala Gln His Arg Leu Pro Gln Pro

145 150 155 160

Pro Val Gly Lys Gly Gly Ala Gly Ala Ser Ser Ser Leu Ser Pro Leu

165 170 175

Gln Ala Glu Leu Leu Pro Pro Leu Leu Glu His Leu Leu Leu Pro Pro

180 185 190

Gln Pro Pro His Pro Ser Leu Ser Tyr Glu Pro Ala Leu Leu Gln Pro

195 200 205

Tyr Leu Phe His Gln Phe Gly Ser Arg Asp Gly Ser Arg Val Ser Glu

210 215 220

Gly Ser Pro Gly Met Val Ser Val Gly Pro Leu Pro Lys Ala Glu Ala

225 230 235 240

Pro Ala Leu Phe Ser Arg Thr Ala Ser Lys Gly Ile Phe Gly Asp His

245 250 255

Pro Gly His Ser Tyr Gly Asp Leu Pro Gly Pro Ser Pro Ala Gln Leu

260 265 270

Phe Gln Asp Ser Gly Leu Leu Tyr Leu Ala Gln Glu Leu Pro Ala Pro

275 280 285

Ser Arg Ala Arg Val Pro Arg Leu Pro Glu Gln Gly Ser Ser Ser Arg

290 295 300

Ala Glu Asp Ser Pro Glu Gly Tyr Glu Lys Glu Gly Leu Gly Asp Arg

305 310 315 320

Gly Glu Lys Pro Ala Ser Pro Ala Val Gln Pro Asp Ala Ala Leu Gln

325 330 335

Arg Leu Ala Ala Val Leu Ala Gly Tyr Gly Val Glu Leu Arg Gln Leu

340 345 350

Thr Pro Glu Gln Leu Ser Thr Leu Leu Thr Leu Leu Gln Leu Leu Pro

355 360 365

Lys Gly Ala Gly Arg Asn Pro Gly Gly Val Val Asn Val Gly Ala Asp

370 375 380

Ile Lys Lys Thr Met Glu Gly Pro Val Glu Gly Arg Asp Thr Ala Glu

385 390 395 400

Leu Pro Ala Arg Thr Ser Pro Met Pro Gly His Pro Thr Ala Ser Pro

405 410 415

Thr Ser Ser Glu Val Gln Gln Val Pro Ser Pro Val Ser Ser Glu Pro

420 425 430

Pro Lys Ala Ala Arg Pro Pro Val Thr Pro Val Leu Leu Glu Lys Lys

435 440 445

Ser Pro Leu Gly Gln Ser Gln Pro Thr Val Ala Gly Gln Pro Ser Ala

450 455 460

Arg Pro Ala Ala Glu Glu Tyr Gly Tyr Ile Val Thr Asp Gln Lys Pro

465 470 475 480

Leu Ser Leu Ala Ala Gly Val Lys Leu Leu Glu Ile Leu Ala Glu His

485 490 495

Val His Met Ser Ser Gly Ser Phe Ile Asn Ile Ser Val Val Gly Pro

500 505 510

Ala Leu Thr Phe Arg Ile Arg His Asn Glu Gln Asn Leu Ser Leu Ala

515 520 525

Asp Val Thr Gln Gln Ala Gly Leu Val Lys Ser Glu Leu Glu Ala Gln

530 535 540

Thr Gly Leu Gln Ile Leu Gln Thr Gly Val Gly Gln Arg Glu Glu Ala

545 550 555 560

Ala Ala Val Leu Pro Gln Thr Ala His Ser Thr Ser Pro Met Arg Ser

565 570 575

Val Leu Leu Thr Leu Val Ala Leu Ala Gly Val Ala Gly Leu Leu Val

580 585 590

Ala Leu Ala Val Ala Leu Cys Val Arg Gln His Ala Arg Gln Gln Asp

595 600 605

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

610 615 620

Thr Phe Glu Tyr Gln Asp Leu Cys Arg Gln His Met Ala Thr Lys Ser

625 630 635 640

Leu Phe Asn Arg Ala Glu Gly Pro Pro Glu Pro Ser Arg Val Ser Ser

645 650 655

Val Ser Ser Gln Phe Ser Asp Ala Ala Gln Ala Ser Pro Ser Ser His

660 665 670

Ser Ser Thr Pro Ser Trp Cys Glu Glu Pro Ala Gln Ala Asn Met Asp

675 680 685

Ile Ser Thr Gly His Met Ile Leu Ala Tyr Met Glu Asp His Leu Arg

690 695 700

Asn Arg Asp Arg Leu Ala Lys Glu Trp Gln Ala Leu Cys Ala Tyr Gln

705 710 715 720

Ala Glu Pro Asn Thr Cys Ala Thr Ala Gln Gly Glu Gly Asn Ile Lys

725 730 735

Lys Asn Arg His Pro Asp Phe Leu Pro Tyr Asp His Ala Arg Ile Lys

740 745 750

Leu Lys Val Glu Ser Ser Pro Ser Arg Ser Asp Tyr Ile Asn Ala Ser

755 760 765

Pro Ile Ile Glu His Asp Pro Arg Met Pro Ala Tyr Ile Ala Thr Gln

770 775 780

Gly Pro Leu Ser His Thr Ile Ala Asp Phe Trp Gln Met Val Trp Glu

785 790 795 800

Ser Gly Cys Thr Val Ile Val Met Leu Thr Pro Leu Val Glu Asp Gly

805 810 815

Val Lys Gln Cys Asp Arg Tyr Trp Pro Asp Glu Gly Ala Ser Leu Tyr

820 825 830

His Val Tyr Glu Val Asn Leu Val Ser Glu His Ile Trp Cys Glu Asp

835 840 845

Phe Leu Val Arg Ser Phe Tyr Leu Lys Asn Val Gln Thr Gln Glu Thr

850 855 860

Arg Thr Leu Thr Gln Phe His Phe Leu Ser Trp Pro Ala Glu Gly Thr

865 870 875 880

Pro Ala Ser Thr Arg Pro Leu Leu Asp Phe Arg Arg Lys Val Asn Lys

885 890 895

Cys Tyr Arg Gly Arg Ser Cys Pro Ile Ile Val His Cys Ser Asp Gly

900 905 910

Ala Gly Arg Thr Gly Thr Tyr Ile Leu Ile Asp Met Val Leu Asn Arg

915 920 925

Met Ala Lys Gly Val Lys Glu Ile Asp Ile Ala Ala Thr Leu Glu His

930 935 940

Val Arg Asp Gln Arg Pro Gly Leu Val Arg Ser Lys Asp Gln Phe Glu

945 950 955 960

Phe Ala Leu Thr Ala Val Ala Glu Glu Val Asn Ala Ile Leu Lys Ala

965 970 975

Leu Pro Gln

<210> 2489

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2489

Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg

1 5 10

<210> 2490

<211> 20

<212>PRT

<213> Mus musculus

<400> 2490

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Ala Leu Asn Phe Leu

1 5 10 15

Val Arg Ser Ser

20

<210> 2491

<211> 18

<212>PRT

<213> Mus musculus

<400> 2491

Phe Ala Ile Asn Ser Glu Met Phe Leu Arg Ser Cys Gln Gly Glu Asn

1 5 10 15

Gly Thr

<210> 2492

<211> 18

<212>PRT

<213> Mus musculus

<400> 2492

Phe Ile Lys Ile Pro Thr His Ala Glu Pro Leu Phe Tyr Leu Leu Ser

1 5 10 15

Phe Cys

<210> 2493

<211> 18

<212>PRT

<213> Mus musculus

<400> 2493

Leu Thr Thr Met Gln Leu Tyr Arg Phe Ile Lys Ile Pro Thr His Ala

1 5 10 15

Glu Pro

<210> 2494

<211> 18

<212>PRT

<213> Mus musculus

<400> 2494

Thr Lys Met Ile Trp Val Ala Val Ile Gly Asp Trp Phe Asn Leu Ile

1 5 10 15

Phe Lys

<210> 2495

<211> 7

<212>PRT

<213> Mycobacterium avium

<400> 2495

Gly Asp Ser Ala Arg Val Leu

15

<210> 2496

<211> 7

<212>PRT

<213> Mycobacterium avium

<400> 2496

His Ala Thr Val Gln Ile Asp

15

<210> 2497

<211> 7

<212>PRT

<213> Mycobacterium avium

<400> 2497

His Leu Ile Ser Thr Gly Asp

15

<210> 2498

<211> 9

<212>PRT

<213> Mycobacterium avium

<400> 2498

Leu Ala Ala Asn Phe Val Val Ala Leu

15

<210> 2499

<211> 7

<212>PRT

<213> Mycobacterium avium

<400> 2499

Leu Ser Pro Gly Lys Asp Met

15

<210> 2500

<211> 9

<212>PRT

<213> Mycobacterium avium

<400> 2500

Met Ile Ala Val Ala Leu Ala Gly Leu

15

<210> 2501

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2501

Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys Met His Ala

1 5 10 15

<210> 2502

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2502

Ile Phe Ser Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys

1 5 10 15

<210> 2503

<211> 23

<212>PRT

<213> Homo sapiens

<400> 2503

Lys Glu Arg Leu Ala Ala Leu Gly Pro Glu Gly Ala His Gly Asp Thr

1 5 10 15

Thr Phe Glu Tyr Gln Asp Leu

20

<210> 2504

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2504

Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile

1 5 10

<210> 2505

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2505

Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser Ile Leu

1 5 10 15

<210> 2506

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2506

Ala Ala Ser Gly Pro Lys Val Val Ile Asp Gly Lys Asp Gln Asn Val

1 5 10 15

Thr Gly Ser Val

20

<210> 2507

<211> 20

<212>PRT

<213> Human herpes virus

<400> 2507

Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala

1 5 10 15

Gly Gly Ala Gly

20

<210> 2508

<211> 21

<212>PRT

<213> Human herpes virus

<400> 2508

Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala

1 5 10 15

Gly Gly Ala Gly Ala

20

<210> 2509

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2509

Ala Gly Lys Pro Leu Leu Ile Ile Ala Glu Asp Val Glu Gly Glu

1 5 10 15

<210> 2510

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2510

Ala Gly Trp Leu Ala Asp Arg Ser Val Arg Tyr Pro Ile

1 5 10

<210> 2511

<211> 10

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2511

Ala Leu Ser Thr Leu Val Val Asn Lys Ile

1 5 10

<210> 2512

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2512

Ala Leu Ser Thr Leu Val Val Asn Lys Ile Arg Gly Thr Phe Lys

1 5 10 15

<210> 2513

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2513

Ala Ser Ala Thr Lys Asp Gly Ser His Tyr Lys Ile Thr Gly Thr Ala

1 5 10 15

Thr Gly Val Asp

20

<210> 2514

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2514

Ala Thr Gly Val Asp Met Ala Asn Pro Met Ser Pro Val Asn Lys Ser

1 5 10 15

Phe Glu Ile Glu

20

<210> 2515

<211> 10

<212>PRT

<213> Human herpes virus

<400> 2515

Ala Val Phe Asp Arg Lys Ser Asp Ala Lys

1 5 10

<210> 2516

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2516

Ala Tyr Arg Arg Arg Trp Arg Arg Leu

15

<210> 2517

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2517

Cys Leu Gly Gly Leu Leu Thr Met Val

15

<210> 2518

<211> 19

<212>PRT

<213> Mycobacterium leprae

<400> 2518

Asp Ala Trp Arg Glu Gly Glu Glu Phe Val Val Glu Phe Asp Leu Pro

1 5 10 15

Gly Ile Lys

<210> 2519

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2519

Asp Gly Asn Pro Pro Glu Val Lys Ser Val Gly Leu Gly Asn Val Asn

1 5 10 15

Gly Val Thr Leu

20

<210> 2520

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2520

Asp Leu Ser Leu Leu Gly Lys Ala Arg Lys Val Val Val Thr Lys Asp

1 5 10 15

<210> 2521

<211> 12

<212>PRT

<213> Human herpes virus

<400> 2521

Asp Ser Glu Leu Glu Ile Lys Arg Tyr Lys Asn Arg

1 5 10

<210> 2522

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2522

Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg

1 5 10 15

<210> 2523

<211> 15

<212>PRT

<213> Mycobacterium bovis

<400> 2523

Asp Val Glu Gly Glu Ala Leu Ser Thr Leu Val Val Asn Lys Ile

1 5 10 15

<210> 2524

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2524

Glu Glu Ser Asn Thr Phe Gly Leu Gln Leu Glu Leu Thr Glu Gly

1 5 10 15

<210> 2525

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2525

Glu Leu Lys Arg Lys Met Ile Tyr Met

15

<210> 2526

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2526

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg

1 5 10 15

<210> 2527

<211> 11

<212>PRT

<213> Human herpes virus

<400> 2527

Glu Pro Leu Pro Gln Gly Gln Leu Thr Ala Tyr

1 5 10

<210> 2528

<211> 6

<212>PRT

<213> Proteus mirabilis

<400> 2528

Glu Ser Arg Arg Ala Leu

15

<210> 2529

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2529

Phe Asp Gln Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe

1 5 10 15

<210> 2530

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2530

Phe Leu Arg Gly Arg Ala Tyr Gly Leu

15

<210> 2531

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2531

Phe Pro Lys Pro Pro Ser Tyr Asn Val Ala Thr Thr Leu Pro Ser Tyr

1 5 10 15

Asp Glu

<210> 2532

<211> 20

<212>PRT

<213> Human herpes virus

<400> 2532

Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly

1 5 10 15

Gly Ala Gly Ala

20

<210> 2533

<211> 24

<212>PRT

<213> Human herpes virus

<400> 2533

Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Gly Gly Arg Pro Gly Ala Pro Gly

20

<210> 2534

<211> 24

<212>PRT

<213> Human herpes virus

<400> 2534

Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Gly Gly Arg Pro Gly Ala Pro Gly

20

<210> 2535

<211> 24

<212>PRT

<213> Human herpes virus

<400> 2535

Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Gly Gly Arg Pro Gly Ala Pro Gly

20

<210> 2536

<211> 24

<212>PRT

<213> Human herpes virus

<400> 2536

Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Gly Gly Arg Pro Gly Ala Pro Gly

20

<210> 2537

<211> 15

<212>PRT

<213> Phaseolus vulgaris

<400> 2537

Gly Gly Tyr Gly Asp Gly Gly Ala His Gly Gly Gly Tyr Gly Gly

1 5 10 15

<210> 2538

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2538

Gly Leu Cys Thr Leu Val Ala Met Leu

15

<210> 2539

<211> 10

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2539

Gly Leu Glu Pro Gly Val Val Ala Glu Lys

1 5 10

<210> 2540

<211> 11

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2540

Gly Leu Glu Pro Gly Val Val Ala Glu Lys Val

1 5 10

<210> 2541

<211> 16

<212>PRT

<213> Mycobacterium leprae

<400> 2541

Gly Met Glu Pro Gly Val Val Ala Glu Lys Val Arg Asn Leu Ser Val

1 5 10 15

<210> 2542

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2542

Ile Ala Phe Asn Ser Gly Leu Glu Pro Gly Val Val Ala Glu Lys

1 5 10 15

<210> 2543

<211> 16

<212>PRT

<213> Mycobacterium leprae

<400> 2543

Ile Ala Phe Asn Ser Gly Met Glu Pro Gly Val Val Ala Glu Lys Val

1 5 10 15

<210> 2544

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2544

Ile Ala Ile Gly Gly Ala Ala Thr Gly Ile Ala Ala Val Leu Thr Asp

1 5 10 15

Gly Asn Pro

20

<210> 2545

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2545

Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys

1 5 10 15

<210> 2546

<211> 14

<212>PRT

<213> Human herpes virus

<400> 2546

Lys Gly Gly Trp Phe Gly Lys His Arg Gly Gln Gly Gly Ser

1 5 10

<210> 2547

<211> 22

<212>PRT

<213> Artemia franciscana

<400> 2547

Lys Lys Glu Glu Lys Lys Glu Glu Ser Glu Glu Glu Asp Glu Asp Met

1 5 10 15

Gly Phe Gly Leu Phe Asp

20

<210> 2548

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2548

Lys Arg Lys Met Ile Tyr Met Cys Tyr

15

<210> 2549

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2549

Lys Arg Pro Pro Ile Phe Ile Arg Arg

15

<210> 2550

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2550

Leu Leu Trp Thr Leu Val Val Leu Leu

15

<210> 2551

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2551

Met Ala Lys Thr Ile Ala Tyr Asp Glu Glu Ala Arg Arg Gly Leu

1 5 10 15

<210> 2552

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2552

Met Ser Pro Val Asn Lys Ser Phe Glu Ile Glu Val Thr Cys Ser

1 5 10 15

<210> 2553

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2553

Asn Leu Val Pro Met Val Ala Thr Val

15

<210> 2554

<211> 13

<212>PRT

<213> Influenza A virus

<400> 2554

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr

1 5 10

<210> 2555

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2555

Pro Lys Tyr Val Lys Arg Asn Thr Leu Lys Leu Ala Thr

1 5 10

<210> 2556

<211> 12

<212>PRT

<213> Clostridium tetani

<400> 2556

Pro Leu Tyr Lys Lys Met Glu Ala Val Lys Leu Arg

1 5 10

<210> 2557

<211> 15

<212>PRT

<213> Mycobacterium species

<400> 2557

Pro Tyr Ile Leu Leu Val Ser Ser Lys Val Ser Thr Val Lys Asp

1 5 10 15

<210> 2558

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2558

Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys Asp

1 5 10 15

<210> 2559

<211> 8

<212>PRT

<213> Human herpes virus

<400> 2559

Arg Ala Lys Phe Lys Gln Leu Leu

15

<210> 2560

<211> 14

<212>PRT

<213> Human herpes virus

<400> 2560

Arg Ala Arg Gly Arg Gly Arg Gly Arg Gly Glu Lys Arg Pro

1 5 10

<210> 2561

<211> 15

<212>PRT

<213> Human herpes virus

<400> 2561

Arg Arg Gly Arg Gly Arg Glu Arg Ala Arg Gly Gly Ser Arg Glu

1 5 10 15

<210> 2562

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2562

Arg Arg Ile Glu Glu Ile Cys Met Lys

15

<210> 2563

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2563

Arg Arg Leu Val Val Thr Leu Gln Cys

15

<210> 2564

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2564

Ser Glu Asn Asp Arg Leu Arg Leu Leu

15

<210> 2565

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2565

Ser Gly Glu Thr Thr Thr Ala Ala Gly Thr Thr Ala Ser Pro Gly Ala

1 5 10 15

Ala Ser Gly Pro

20

<210> 2566

<211> 13

<212>PRT

<213> Influenza A virus

<400> 2566

Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu

1 5 10

<210> 2567

<211> 7

<212>PRT

<213> Mus musculus

<400> 2567

Ser Leu Ala Tyr Gly Leu Arg

15

<210> 2568

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2568

Ser Val Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met

1 5 10 15

<210> 2569

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2569

Ser Val Arg Asp Arg Leu Ala Arg Leu

15

<210> 2570

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2570

Thr Phe Gly Ala Gln Leu Glu Leu Thr

15

<210> 2571

<211> 9

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2571

Thr Phe Gly Leu Gln Leu Glu Leu Thr

15

<210> 2572

<211> 15

<212>PRT

<213> Human T-cell lymphotropic virus

<400> 2572

Thr Asn Ser His Val Pro Ile Leu Gln Glu Arg Pro Pro Leu Glu

1 5 10 15

<210> 2573

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2573

Val Ala Gly Leu Ser Gly Cys Ser Ser Asn Lys Ser Thr Thr Gly Ser

1 5 10 15

Gly Glu Thr Thr

20

<210> 2574

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2574

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln

1 5 10 15

Arg

<210> 2575

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2575

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln

1 5 10 15

Arg Met Glu

<210> 2576

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2576

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln

1 5 10 15

Arg Met Glu Pro

20

<210> 2577

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2577

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln

1 5 10 15

Arg Met Glu Pro Arg

20

<210> 2578

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2578

Val Thr Gly Ser Val Val Cys Thr Thr Ala Ala Gly Asn Val Asn Ile

1 5 10 15

Ala Ile Gly Gly

20

<210> 2579

<211> 15

<212>PRT

<213> Mycobacterium bovis

<400> 2579

Val Val Ala Glu Lys Val Arg Asn Leu Pro Ala Gly His Gly Leu

1 5 10 15

<210> 2580

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2580

Tyr Val Leu Asp His Leu Ile Val Val

15

<210> 2581

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2581

Lys Phe Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu

1 5 10 15

Leu Ala Asp Ala

20

<210> 2582

<211> 22

<212>PRT

<213> Human herpes virus

<400> 2582

Gly Gly Ala Gly Ala Gly Gly Gly Ala Gly Gly Ala Gly Ala Gly Gly

1 5 10 15

Gly Ala Gly Gly Ala Gly

20

<210> 2583

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2583

Gly Leu Lys Gly Glu Gln Gly Glu Pro Gly Ala

1 5 10

<210> 2584

<211> 11

<212>PRT

<213> Gallus gallus

<400> 2584

Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10

<210> 2585

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2585

Met Lys Arg Gly Leu Thr Val Ala Val Ala Gly Ala Ala Ile Leu Val

1 5 10 15

Ala Gly Leu Ser

20

<210> 2586

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2586

Asn Gly Val Thr Leu Gly Tyr Thr Ser Gly Thr Cys Gln Gly Asn Ala

1 5 10 15

Ser Ala Thr Lys

20

<210> 2587

<211> 26

<212>PRT

<213> Gallus gallus

<400> 2587

Pro Thr Gly Pro Leu Gly Pro Lys Gly Gln Thr Gly Glu Leu Gly Ile

1 5 10 15

Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

20 25

<210> 2588

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2588

Ala Asp Gly Gly Ala Gln Gly Thr Ala

15

<210> 2589

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2589

Ala Asp Ile Trp Leu Thr Pro Asp Pro Thr Thr Pro

1 5 10

<210> 2590

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2590

Cys Val Asp Thr Arg Ser Gly Asn Cys Tyr Leu Asp Ile Arg Pro

1 5 10 15

<210> 2591

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2591

Asp Val Tyr Trp Leu Met Pro Asp Pro Pro Thr Ser

1 5 10

<210> 2592

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2592

Glu Pro Val Ser Gly Ser Phe Thr Thr Ala Leu Asp Gly Pro Ser

1 5 10 15

<210> 2593

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2593

Phe Phe Tyr Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro

1 5 10 15

<210> 2594

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 2594

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Thr

1 5 10 15

<210> 2595

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2595

Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly

1 5 10 15

Glu Gln Gly Pro Lys

20

<210> 2596

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2596

Gly Pro Lys Gly Gln Thr Gly Lys Pro Gly Ile Ala Gly Phe Lys Gly

1 5 10 15

Glu Gln Gly Pro Lys

20

<210> 2597

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2597

Gly Thr Ser Thr Glu Val Trp Leu Ala Pro Asp Pro

1 5 10

<210> 2598

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2598

Gly Val Val Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu

1 5 10 15

<210> 2599

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2599

His Leu Pro Ser Phe Leu Arg Pro Asp Pro Pro Leu

1 5 10

<210> 2600

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2600

Ile Phe Pro Ser Phe Leu Arg Pro Asp Pro Pro Leu

1 5 10

<210> 2601

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2601

Ile Ser Gly Leu Pro Ser Gly Gly Asp Asp Leu Glu Thr Ser Thr

1 5 10 15

<210> 2602

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2602

Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His Ala Met Leu

1 5 10 15

<210> 2603

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2603

Leu Ser Gly Leu Pro Ser Gly Gly Glu Val Leu Glu Ile Ser Val

1 5 10 15

<210> 2604

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2604

Leu Ser Ser Arg Glu Pro Gln Ala Arg

15

<210> 2605

<211> 11

<212>PRT

<213> Rattus norvegicus

<400> 2605

Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro

1 5 10

<210> 2606

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2606

Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys

1 5 10 15

Lys

<210> 2607

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2607

Asn Ser Asp His Phe Leu Gln Pro Asp Pro Pro Leu

1 5 10

<210> 2608

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2608

Pro Gly Pro Ser Arg Ala His Phe Leu

15

<210> 2609

<211> 15

<212>PRT

<213> Escherichia coli

<400> 2609

Gln Lys Arg Ala Ala Tyr Asp Gln Tyr Gly His Ala Ala Phe Glu

1 5 10 15

<210> 2610

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2610

Arg Leu Thr Arg Glu Leu Tyr Ala Gln

15

<210> 2611

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2611

Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr Gly Val Gly

1 5 10

<210> 2612

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2612

Val Lys Glu Gly His Ser Pro Pro Asp Asp Val Asp Ile Val Ile

1 5 10 15

<210> 2613

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2613

Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro

1 5 10 15

<210> 2614

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2614

Tyr Thr Gln Lys His Lys His Gln Ala

15

<210> 2615

<211> 13

<212>PRT

<213> Bos taurus

<400> 2615

Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro

1 5 10

<210> 2616

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2616

Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala

1 5 10

<210> 2617

<211> 15

<212>PRT

<213> Mus musculus

<400> 2617

Ala Thr Glu Gly Gln Val Arg Val Asn Ser Ile Tyr Gln Asp Lys

1 5 10 15

<210> 2618

<211> 15

<212>PRT

<213> Bos taurus

<400> 2618

Ala Thr Tyr Lys Arg Arg Leu Gln Lys Arg Ser Ser Arg Pro Leu

1 5 10 15

<210> 2619

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2619

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Asp Gln Gly Pro Lys Gly

1 5 10 15

Glu Pro Gly Pro Ala

20

<210> 2620

<211> 12

<212>PRT

<213> Rattus norvegicus

<400> 2620

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10

<210> 2621

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 2621

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Thr

1 5 10 15

<210> 2622

<211> 8

<212>PRT

<213> Homo sapiens

<400> 2622

Leu Lys Phe Val Glu Gln Asn Glu

15

<210> 2623

<211> 15

<212>PRT

<213> Mus musculus

<400> 2623

Asn Thr Tyr Lys His Arg Leu Gln Lys Arg Thr Met Arg Pro Thr

1 5 10 15

<210> 2624

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2624

Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu

1 5 10

<210> 2625

<211> 26

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2625

Pro Thr Gly Pro Leu Gly Pro Lys Gly Gln Thr Gly Glu Leu Gly Ala

1 5 10 15

Pro Gly Asn Lys Gly Glu Gln Gly Pro Lys

20 25

<210> 2626

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2626

Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn Thr Gln Ser Arg

1 5 10

<210> 2627

<211> 15

<212>PRT

<213> Canis lupus

<400> 2627

Ser Thr Tyr Lys Arg Arg Leu Gln Lys Arg Ser Ser Arg Ala Pro

1 5 10 15

<210> 2628

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2628

Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

Gly Glu Pro Gly

20

<210> 2629

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2629

Thr Thr Tyr Lys Arg Arg Leu Gln Lys Arg Ala Ala Arg His Pro

1 5 10 15

<210> 2630

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2630

Thr Tyr Lys Arg Arg Leu Gln Lys Arg

15

<210> 2631

<211> 14

<212>PRT

<213> Sus scrofa

<400> 2631

Thr Tyr Lys Arg Arg Leu Gln Lys Arg Ser Ser Arg Ser Leu

1 5 10

<210> 2632

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2632

Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val

1 5 10

<210> 2633

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2633

Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp Arg Ser Val

1 5 10 15

Arg Tyr

<210> 2634

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2634

Ala Leu Pro Ala Pro Ile Glu

15

<210> 2635

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2635

Ala Pro Ile Glu Lys Thr Ile

15

<210> 2636

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2636

Cys Lys Val Ser Asn Lys Ala

15

<210> 2637

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2637

Asp Gly Lys Glu Tyr Lys Cys

15

<210> 2638

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2638

Asp Val Ser His Glu Asp Pro

15

<210> 2639

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2639

Glu Asp Pro Gln Val Lys Phe

15

<210> 2640

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2640

Glu Lys Thr Ile Ser Lys Ala

15

<210> 2641

<211> 6

<212>PRT

<213> Homo sapiens

<400> 2641

Glu Gln Arg Arg Ala Ala

15

<210> 2642

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2642

Glu Tyr Lys Cys Lys Val Ser

15

<210> 2643

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2643

Phe Leu Phe Pro Pro Lys Pro

15

<210> 2644

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2644

Phe Asn Trp Tyr Val Asp Gly

15

<210> 2645

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2645

Phe Pro Pro Lys Pro Lys Asp

15

<210> 2646

<211> 16

<212>PRT

<213> Bos taurus

<400> 2646

Gly Ala Arg Gly Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly

1 5 10 15

<210> 2647

<211> 15

<212>PRT

<213> Bos taurus

<400> 2647

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

<210> 2648

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 2648

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

<210> 2649

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 2649

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

<210> 2650

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2650

Gly Lys Glu Tyr Lys Cys Lys

15

<210> 2651

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2651

Gly Lys Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly

1 5 10 15

<210> 2652

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2652

Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys

1 5 10 15

<210> 2653

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2653

Gly Pro Ser Val Phe Leu Phe

15

<210> 2654

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2654

Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg

1 5 10

<210> 2655

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2655

Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr Gly Val Gly Ala Pro

1 5 10 15

<210> 2656

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2656

Gly Thr Ser Leu Thr Ile Pro Cys Tyr Phe Ile Asp Pro Met His

1 5 10 15

<210> 2657

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2657

Gly Val Gln Val His Asn Ala

15

<210> 2658

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2658

His Gln Asn Trp Leu Asp Gly

15

<210> 2659

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2659

Ile Glu Lys Thr Ile Ser Lys

15

<210> 2660

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2660

Ile Ser Lys Ala Lys Gly Gln

15

<210> 2661

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2661

Lys Ala Leu Pro Ala Pro Ile

15

<210> 2662

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2662

Lys Cys Lys Val Ser Asn Lys

15

<210> 2663

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2663

Lys Glu Tyr Lys Cys Lys Val

15

<210> 2664

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2664

Lys Phe Asn Trp Tyr Val Asp

15

<210> 2665

<211> 15

<212>PRT

<213> Gallus gallus

<400> 2665

Lys Gly Gln Thr Gly Glu Leu Gly Ile Ala Gly Phe Lys Gly Glu

1 5 10 15

<210> 2666

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2666

Lys Pro Arg Glu Gln Gln Tyr

15

<210> 2667

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2667

Lys Thr Ile Ser Lys Ala Lys

15

<210> 2668

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2668

Lys Thr Lys Pro Arg Glu Gln

15

<210> 2669

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2669

Lys Val Ser Asn Lys Ala Leu

15

<210> 2670

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2670

Leu Asp Gly Lys Glu Tyr Lys

15

<210> 2671

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2671

Leu Phe Pro Pro Lys Pro Lys

15

<210> 2672

<211> 33

<212>PRT

<213> Homo sapiens

<400> 2672

Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys

1 5 10 15

Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly

20 25 30

Ala

<210> 2673

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2673

Leu His Gln Asn Trp Leu Asp

15

<210> 2674

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2674

Leu Pro Ala Pro Ile Glu Lys

15

<210> 2675

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2675

Leu Thr Val Leu His Gln Asn

15

<210> 2676

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2676

Met Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu

1 5 10 15

<210> 2677

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2677

Asn Ala Lys Thr Lys Pro Arg

15

<210> 2678

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2678

Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn Thr Gln Ser

1 5 10 15

<210> 2679

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2679

Asn Lys Ala Leu Pro Ala Pro

15

<210> 2680

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2680

Asn Ser Thr Tyr Arg Val Val

15

<210> 2681

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2681

Asn Trp Leu Asp Gly Lys Glu

15

<210> 2682

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2682

Asn Trp Tyr Val Asp Gly Val

15

<210> 2683

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2683

Pro Ala Pro Ile Glu Lys Thr

15

<210> 2684

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2684

Pro Ile Glu Lys Thr Ile Ser

15

<210> 2685

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2685

Pro Gln Val Lys Phe Asn Trp

15

<210> 2686

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2686

Pro Arg Glu Gln Gln Tyr Asn

15

<210> 2687

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2687

Pro Ser Val Phe Leu Phe Pro

15

<210> 2688

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2688

Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe His Gly Ala

1 5 10 15

<210> 2689

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2689

Gln Asn Trp Leu Asp Gly Lys

15

<210> 2690

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2690

Gln Gln Tyr Asn Ser Thr Tyr

15

<210> 2691

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2691

Gln Val Lys Phe Asn Trp Tyr

15

<210> 2692

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2692

Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser Lys Val Gln

1 5 10 15

<210> 2693

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2693

Gln Tyr Asn Ser Thr Tyr Arg

15

<210> 2694

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2694

Arg Glu Gln Gln Tyr Asn Ser

15

<210> 2695

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2695

Arg Val Val Ser Val Leu Thr

15

<210> 2696

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2696

Ser Cys Phe Pro Asp Ala Leu Asp Arg Phe Leu Cys Thr His Ile Ile

1 5 10 15

<210> 2697

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2697

Ser Asn Lys Ala Leu Pro Ala

15

<210> 2698

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2698

Ser Val Phe Leu Phe Pro Pro

15

<210> 2699

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2699

Ser Val Leu Thr Val Leu His

15

<210> 2700

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2700

Thr Ile Ser Lys Ala Lys Gly

15

<210> 2701

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2701

Thr Val Leu His Gln Asn Trp

15

<210> 2702

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2702

Thr Tyr Arg Val Val Ser Val

15

<210> 2703

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2703

Val Asp Gly Val Gln Val His

15

<210> 2704

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2704

Val Phe Leu Phe Pro Pro Lys

15

<210> 2705

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2705

Val His Asn Ala Lys Thr Lys

15

<210> 2706

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2706

Val Lys Phe Asn Trp Tyr Val

15

<210> 2707

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2707

Val Leu His Gln Asn Trp Leu

15

<210> 2708

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2708

Val Ser Asn Lys Ala Leu Pro

15

<210> 2709

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2709

Val Ser Val Leu Thr Val Leu

15

<210> 2710

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2710

Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser Ala

1 5 10 15

Tyr Gln

<210> 2711

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2711

Val Val Ser Val Leu Thr Val

15

<210> 2712

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2712

Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile Ser Thr Arg

1 5 10 15

Tyr Thr

<210> 2713

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2713

Trp Leu Asp Gly Lys Glu Tyr

15

<210> 2714

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2714

Trp Tyr Val Asp Gly Val Gln

15

<210> 2715

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2715

Tyr Lys Cys Lys Val Ser Asn

15

<210> 2716

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2716

Tyr Leu Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp

1 5 10 15

<210> 2717

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2717

Tyr Asn Ser Thr Tyr Arg Val

15

<210> 2718

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2718

Tyr Arg Val Val Ser Val Leu

15

<210> 2719

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2719

Tyr Val Asp Gly Val Gln Val

15

<210> 2720

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2720

Ala Ala Arg Gln Arg Leu Gln Asp Ile

15

<210> 2721

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2721

Ala Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile

1 5 10

<210> 2722

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2722

Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile

1 5 10

<210> 2723

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2723

Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro

1 5 10

<210> 2724

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2724

Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser Gly Val Tyr

1 5 10 15

Arg Cys

<210> 2725

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2725

Ala Trp Asn Cys Cys Val Lys Gln Thr Pro

1 5 10

<210> 2726

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 2726

Ala Tyr Asp Glu Glu Ala Arg Arg Gly Leu Glu Arg Gly Leu Asn Ala

1 5 10 15

Leu Ala Asp Ala

20

<210> 2727

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2727

Cys Leu Gly Gly Leu Leu Thr Met Asn

15

<210> 2728

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2728

Cys Ser Val Met His Glu Gly

15

<210> 2729

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2729

Asp Ala Gly Pro Gln Gly Lys Val Gly Pro Ser

1 5 10

<210> 2730

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2730

Asp Gly Ser Phe Phe Leu Tyr

15

<210> 2731

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2731

Asp Ser Gly His Arg Gly Tyr Ser Gly Ser Gln Ala Ser Asp Asn Glu

1 5 10 15

Gly His

<210> 2732

<211> 9

<212>PRT

<213> Porphyromonas gingivalis

<400> 2732

Asp Ser Arg Gly Asn Pro Thr Val Glu

15

<210> 2733

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2733

Glu Gly Leu His Asn His Tyr

15

<210> 2734

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2734

Glu Arg Gly Leu Lys Gly His Arg Gly Phe Thr

1 5 10

<210> 2735

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2735

Gly Gly Gln Gly Ser Arg His Gln Gln Ala Arg

1 5 10

<210> 2736

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2736

Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala

1 5 10

<210> 2737

<211> 9

<212>PRT

<213> Bos taurus

<400> 2737

Gly Pro Ala Gly Pro Ala Gly Glu Arg

15

<210> 2738

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2738

Gly Pro Lys Val Lys Arg Pro Pro Ile

15

<210> 2739

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2739

Gly Trp Val Ala Met His Pro Gln Gly Asp Leu

1 5 10

<210> 2740

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2740

His Gln Cys His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Cys

1 5 10 15

Gly Arg Ser Gly Ser

20

<210> 2741

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2741

His Ser Ala Ser Gln Asp Gly Gln Asp Thr Ile Arg Gly His Pro Gly

1 5 10 15

Ser Ser

<210> 2742

<211> 22

<212>PRT

<213> Homo sapiens

<400> 2742

His Ser Gly Ile Gly His Gly Gln Ala Ser Ser Ala Val Arg Asp Ser

1 5 10 15

Gly His Arg Gly Tyr Ser

20

<210> 2743

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2743

His Ser Thr Ser Gln Glu Gly Gln Asp Thr Ile His Gly His Arg Gly

1 5 10 15

Ser

<210> 2744

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2744

Lys Ser Leu Ser Leu Ser Pro

15

<210> 2745

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2745

Leu Gly Leu Arg Leu Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu

1 5 10 15

Lys Gly Asp Ile

20

<210> 2746

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2746

Leu Gly Trp Met Arg Tyr His Pro Gln Ala

1 5 10

<210> 2747

<211> 10

<212>PRT

<213> Human herpes virus

<400> 2747

Leu Leu Asp Phe Val Arg Phe Met Gly Tyr

1 5 10

<210> 2748

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2748

Leu Leu Pro Trp Leu Asp Gly His Pro Met

1 5 10

<210> 2749

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2749

Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr

1 5 10

<210> 2750

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2750

Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro

1 5 10

<210> 2751

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2751

Asn Trp Leu Ser Leu Ile Thr Ala Ala Arg

1 5 10

<210> 2752

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2752

Pro Glu Phe Ser Gly Leu Pro Ser Gly Ile Ala Glu Val

1 5 10

<210> 2753

<211> 15

<212>PRT

<213> Mus musculus

<400> 2753

Pro Pro Gly Ala Asn Gly Asn Pro Gly Pro Ala Gly Pro Pro Gly

1 5 10 15

<210> 2754

<211> 9

<212>PRT

<213> Homo sapiens

<400> 2754

Pro Pro Gly Pro Thr Gly Ala Ser Gly

15

<210> 2755

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2755

Pro Gln Val Tyr Thr Leu Pro

15

<210> 2756

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2756

Pro Arg Glu Pro Gln Val Tyr

15

<210> 2757

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2757

Gln Gly Lys Val Gly Pro Ser Gly Ala Pro Gly

1 5 10

<210> 2758

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2758

Gln Leu Leu Gln His Tyr Arg Glu Val

15

<210> 2759

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2759

Arg Gly Phe Thr Gly Leu Gln Gly Leu Pro Gly Pro Pro Gly Pro Ser

1 5 10 15

Gly Asp

<210> 2760

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2760

Arg Arg Leu Pro Phe Gly Ser Gln Met

15

<210> 2761

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2761

Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val

1 5 10 15

<210> 2762

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2762

Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly

1 5 10 15

Gly Gly Lys

<210> 2763

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2763

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2764

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2764

Ser Ile Phe Phe Ala Val Val Leu Glu Leu

1 5 10

<210> 2765

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2765

Ser Leu Cys Ile Asn Leu Arg Ala Ala Arg

1 5 10

<210> 2766

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2766

Ser Leu Ile Thr Ala Ala Arg Gly Ala Pro Ser

1 5 10

<210> 2767

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2767

Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr

1 5 10 15

Lys

<210> 2768

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2768

Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr

1 5 10 15

Ser

<210> 2769

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2769

Val Asp Leu Met Thr Ile Arg Ser Cys Arg

1 5 10

<210> 2770

<211> 9

<212>PRT

<213> Human herpes virus

<400> 2770

Val Met Ala Thr Leu Leu Pro Pro Val

15

<210> 2771

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2771

Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln

1 5 10

<210> 2772

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2772

Trp Phe Thr Ser Trp Glu Arg Asp Trp Trp

1 5 10

<210> 2773

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2773

Trp Pro Pro Ser Phe Trp Tyr His Pro Gln

1 5 10

<210> 2774

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2774

Trp Val Ala Met His Pro Gln Gly Asp Leu

1 5 10

<210> 2775

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2775

Trp Trp Ala Thr Phe Phe Glu Ala Thr Arg

1 5 10

<210> 2776

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2776

Trp Trp Asn Met Phe Gln Met Gly Val Val

1 5 10

<210> 2777

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2777

Ala Ala Phe Ser Glu Leu Pro Leu Gly

15

<210> 2778

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2778

Ala Asp Ala Ser Val Pro Val Met Pro

15

<210> 2779

<211> 15

<212>PRT

<213> Bos taurus

<400> 2779

Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro

1 5 10 15

<210> 2780

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2780

Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala

1 5 10 15

Gly Pro

<210> 2781

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2781

Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala

1 5 10 15

Gly Pro

<210> 2782

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2782

Ala Lys Tyr Ser Asn Gln Arg Ala Gln

15

<210> 2783

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2783

Ala Leu Ala Arg Leu Met Pro Gly Ser

15

<210> 2784

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2784

Ala Pro Arg Arg Leu Phe Asp Ile Ala

15

<210> 2785

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2785

Ala Pro Ser Ser Leu Ala Gly Asn Gly

15

<210> 2786

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2786

Ala Gln Ala Tyr Asp Leu Ser Pro Ser

15

<210> 2787

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2787

Ala Gln Ser Ala Ile Thr Ala Cys Trp

15

<210> 2788

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2788

Ala Ser Lys Ala Lys Ala Arg Pro Val

15

<210> 2789

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2789

Ala Thr Ala Asp Tyr Pro Gln Lys Ser

15

<210> 2790

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2790

Ala Thr Asn Ile Phe Ile Glu Gly Thr

15

<210> 2791

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2791

Cys Thr Arg His Pro Asp Cys Gln Ala

15

<210> 2792

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2792

Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg

1 5 10 15

<210> 2793

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2793

Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

1 5 10 15

<210> 2794

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2794

Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

1 5 10 15

Arg

<210> 2795

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2795

Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser Ile Tyr Ala Tyr Asp

1 5 10 15

<210> 2796

<211> 18

<212>PRT

<213> Bos taurus

<400> 2796

Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu

1 5 10 15

Pro Gly

<210> 2797

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2797

Glu Gln Ala Gln Ser Gln Thr Leu Pro

15

<210> 2798

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2798

Glu Val Ala His Pro Ser Val Pro Leu

15

<210> 2799

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2799

Phe Glu Asp Met Ala Lys Ser Asp Lys Ala Arg Tyr Asp Arg Glu

1 5 10 15

<210> 2800

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2800

Phe Leu Ala Glu Gly Gly Gly Val Arg Gly Pro Arg Val Val Glu Arg

1 5 10 15

His

<210> 2801

<211> 12

<212>PRT

<213> Homo sapiens

<400> 2801

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg

1 5 10

<210> 2802

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2802

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln

1 5 10

<210> 2803

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2803

Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met

1 5 10

<210> 2804

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2804

Gly Ala Ser Gly Asp Ile Ala Lys Gln

15

<210> 2805

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2805

Gly Gly Glu Thr Leu Leu His Met Ala

15

<210> 2806

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2806

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro

1 5 10 15

<210> 2807

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2807

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Pro

1 5 10 15

<210> 2808

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 2808

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Thr

1 5 10 15

<210> 2809

<211> 15

<212>PRT

<213> Bos taurus

<400> 2809

Gly Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro

1 5 10 15

<210> 2810

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2810

Gly Pro Pro Arg Arg Leu Ile Asp Thr

15

<210> 2811

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2811

Gly Arg Thr Pro Glu Asp Asn Thr Leu

15

<210> 2812

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2812

Gly Trp Pro Val Ala Pro Asp Pro Ala

15

<210> 2813

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2813

His Ala Lys Lys Thr Pro Pro Ala Ser

15

<210> 2814

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2814

His Glu Leu Gly Asp Ile Ala Ile Ala

15

<210> 2815

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2815

His Leu Arg Gln Gly Arg Asn Thr Ala

15

<210> 2816

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2816

His Gln Cys His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Cys

1 5 10 15

Gly Arg Ser Gly Ser

20

<210> 2817

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2817

Ile Arg Arg Ser Glu Thr Pro Arg Ala

15

<210> 2818

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2818

Ile Arg Tyr His Thr Asn Trp Ser Ser

15

<210> 2819

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2819

Ile Tyr Phe Arg Asn Gln Lys Gly His Ser Gly Leu Gln Pro Thr Gly

1 5 10 15

Phe Leu Ser

<210> 2820

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2820

Ile Tyr Phe Arg Asn Gln Lys Gly His Ser Gly Leu Gln Pro Thr Gly

1 5 10 15

Leu Leu Ser

<210> 2821

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2821

Lys Glu Lys Ser Lys Phe Glu Asp Met Ala Lys Ser Asp Lys Ala

1 5 10 15

<210> 2822

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2822

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

1 5 10 15

<210> 2823

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2823

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

<210> 2824

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2824

Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala Pro Lys Arg Pro Pro

1 5 10 15

<210> 2825

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2825

Lys Met Pro Ile Glu Ala Asp Pro Leu

15

<210> 2826

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2826

Lys Ser Asp Lys Ala Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val

1 5 10 15

<210> 2827

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2827

Lys Ser Gly Pro Ile Asp Ile Ile Gly

15

<210> 2828

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2828

Lys Thr Met Ser Ala Lys Glu Lys Ser Lys Phe Glu Asp Met Ala

1 5 10 15

<210> 2829

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2829

Leu Gly Leu His Ala Leu Gln Ser Pro

15

<210> 2830

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2830

Leu Gly Arg Asp Ala Asn Ala Trp Lys

15

<210> 2831

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2831

Leu Leu Arg Pro Val Ala Arg Asp Thr

15

<210> 2832

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2832

Leu Asn Thr Ala Lys His Arg Glu Ser

15

<210> 2833

<211> 13

<212>PRT

<213> Homo sapiens

<400> 2833

Leu Pro Ser Tyr Glu Glu Ala Leu Ser Leu Pro Ser Lys

1 5 10

<210> 2834

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2834

Leu Ser Arg Ala Ser Leu Lys Thr Leu

15

<210> 2835

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2835

Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln

1 5 10 15

<210> 2836

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2836

Leu Val Gly Thr Pro Gln Lys Thr Lys

15

<210> 2837

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2837

Met Lys Asn Tyr Val Pro Pro Lys Gly Asp Lys Lys Gly Lys Lys

1 5 10 15

<210> 2838

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2838

Asn Lys Ala Leu Thr Phe Phe Leu Pro

15

<210> 2839

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2839

Asn Leu Phe Thr Gln Thr Gly Thr Pro

15

<210> 2840

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2840

Asn Asn Ser Phe Glu Lys Val Lys Gln

15

<210> 2841

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2841

Asn Ser Ser Pro Tyr Leu Asn Thr Lys

15

<210> 2842

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2842

Pro Asp His Leu Pro Arg His Val Ser

15

<210> 2843

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2843

Pro Glu Ile Ile Glu Asn Phe Asp Pro

15

<210> 2844

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2844

Pro Leu Thr Asn Arg Arg Leu Arg Gly

15

<210> 2845

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2845

Pro Pro Lys Gly Asp Lys Lys Gly Lys Lys Lys Asp Pro Asn Ala

1 5 10 15

<210> 2846

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2846

Pro Pro Leu Leu Leu Thr Asp Val Thr

15

<210> 2847

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2847

Pro Gln Ser Pro Gly Ser Ser Phe Pro

15

<210> 2848

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2848

Pro Ser Phe Pro Pro Ala Leu Arg Leu

15

<210> 2849

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2849

Pro Val Ser Ser Thr Arg Gly Asn Met

15

<210> 2850

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2850

Pro Tyr Pro Phe Ala Gln Lys Arg Leu

15

<210> 2851

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2851

Gln Ser Pro Arg Leu Tyr Pro Gly Ser

15

<210> 2852

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2852

Arg Gly Gly Ile Arg Arg Gln Ser Leu

15

<210> 2853

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2853

Arg Lys Ala Leu Arg Leu Ser Ala Ser

15

<210> 2854

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2854

Arg Pro Pro His Ser Ala Ser Trp Arg

15

<210> 2855

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2855

Arg Arg Gly Pro Glu Ala His Gln Ala

15

<210> 2856

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2856

Arg Arg Arg Val Arg Asn Ser Asp Thr

15

<210> 2857

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2857

Arg Tyr Asp Arg Glu Met Lys Asn Tyr Val Pro Pro Lys Gly Asp

1 5 10 15

<210> 2858

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2858

Ser Glu Ser Thr Ile Gln Asn Leu Arg

15

<210> 2859

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2859

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser

1 5 10

<210> 2860

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2860

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2861

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2861

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2862

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2862

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2863

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2863

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2864

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2864

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2865

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2865

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2866

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2866

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2867

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2867

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2868

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2868

Ser Thr Leu Val Pro Asn Lys Ala Pro

15

<210> 2869

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2869

Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly Gly

1 5 10 15

<210> 2870

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2870

Thr Phe Arg Asp Leu His Gln Gln Gln

15

<210> 2871

<211> 14

<212>PRT

<213> Homo sapiens

<400> 2871

Thr Gly Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu

1 5 10

<210> 2872

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2872

Thr Gly Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu Gln Ala

1 5 10 15

Gln

<210> 2873

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2873

Thr Gly Pro Ser Thr Arg Gly Arg Gln Gly Ser Arg His Glu Gln Ala

1 5 10 15

Gln

<210> 2874

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2874

Thr Ile His Ala His Pro Gly Ser Arg Arg Gly Gly Arg His Gly Tyr

1 5 10 15

His His

<210> 2875

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2875

Thr Leu Thr Phe Thr Leu Asn Lys Leu Arg

1 5 10

<210> 2876

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2876

Thr Pro Asp Ser Leu Gly Arg Pro Ser

15

<210> 2877

<211> 17

<212>PRT

<213> Homo sapiens

<400> 2877

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro

1 5 10 15

Arg

<210> 2878

<211> 21

<212>PRT

<213> Homo sapiens

<400> 2878

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro

1 5 10 15

Arg Gly Glu Pro Arg

20

<210> 2879

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2879

Val Pro Val Asp Ala Gly Thr Ala Lys

15

<210> 2880

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2880

Tyr Lys Leu Arg Arg Ala Tyr Tyr Ala

15

<210> 2881

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2881

Tyr Thr Leu Gln Lys Ala Val Leu Ser

15

<210> 2882

<211> 11

<212>PRT

<213> Rattus norvegicus

<400> 2882

Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala

1 5 10

<210> 2883

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2883

Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr

1 5 10 15

<210> 2884

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2884

Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly

1 5 10 15

<210> 2885

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2885

Asp Glu Leu Thr Lys Asn Gln

15

<210> 2886

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2886

Asp Lys Ser Arg Trp Gln Glu

15

<210> 2887

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2887

Asp Pro Ile Ser Gly His Val Ser Leu Phe

1 5 10

<210> 2888

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2888

Asp Ser Asp Gly Ser Phe Phe

15

<210> 2889

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2889

Glu Ala Leu His Asn His Tyr Gln Lys Ser

1 5 10

<210> 2890

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2890

Glu Gly Asn Val Phe Ser Cys

15

<210> 2891

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2891

Glu Asn Tyr Lys Thr Thr Pro

15

<210> 2892

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2892

Glu Pro Gln Val Tyr Thr Leu

15

<210> 2893

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2893

Glu Trp Gly Ser Asn Asp Gly

15

<210> 2894

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2894

Phe Phe Leu Tyr Ser Lys Leu

15

<210> 2895

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2895

Phe Leu Tyr Ser Lys Leu Thr

15

<210> 2896

<211> 15

<212>PRT

<213> Bos taurus

<400> 2896

Gly Glu Arg Gly Ser Pro Gly Ala Val Gly Pro Lys Gly Ser Pro

1 5 10 15

<210> 2897

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2897

Gly Leu His Asn His Tyr Thr

15

<210> 2898

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2898

Gly Asn Val Phe Ser Cys Ser

15

<210> 2899

<211> 15

<212>PRT

<213> Bos taurus

<400> 2899

Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Ala Gln Gly Pro Arg

1 5 10 15

<210> 2900

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2900

Gly Gln Pro Arg Glu Pro Gln

15

<210> 2901

<211> 15

<212>PRT

<213> Bos taurus

<400> 2901

Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro

1 5 10 15

<210> 2902

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2902

Gly Ser Phe Phe Leu Tyr Ser

15

<210> 2903

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2903

His Glu Gly Leu His Asn His

15

<210> 2904

<211> 8

<212>PRT

<213> Rattus norvegicus

<400> 2904

Ile Ala Gly Phe Lys Gly Glu Gln

15

<210> 2905

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2905

Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala

1 5 10 15

<210> 2906

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2906

Lys Asn Gln Val Ser Leu Thr

15

<210> 2907

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2907

Lys Pro Ile Ser Gly His Asn Ser Leu Phe

1 5 10

<210> 2908

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2908

Lys Ser Arg Trp Gln Glu Gly

15

<210> 2909

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2909

Leu Asp Ser Asp Gly Ser Phe

15

<210> 2910

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2910

Leu His Asn His Tyr Thr Gln

15

<210> 2911

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2911

Leu Thr Lys Asn Gln Val Ser

15

<210> 2912

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2912

Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro

1 5 10

<210> 2913

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2913

Met His Glu Gly Leu His Asn

15

<210> 2914

<211> 14

<212>PRT

<213> Rattus norvegicus

<400> 2914

Met Pro Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys

1 5 10

<210> 2915

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2915

Asn Gln Val Ser Leu Thr Cys

15

<210> 2916

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2916

Asn Val Phe Ser Cys Ser Val

15

<210> 2917

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2917

Asn Tyr Lys Thr Thr Pro Pro

15

<210> 2918

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2918

Pro Pro Ser Arg Asp Glu Leu

15

<210> 2919

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2919

Pro Pro Ser Arg Glu Glu Met

15

<210> 2920

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2920

Pro Ser Arg Asp Glu Leu Thr

15

<210> 2921

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2921

Pro Ser Arg Glu Glu Met Thr

15

<210> 2922

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2922

Gln Lys Ser Leu Ser Leu Ser

15

<210> 2923

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2923

Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu

1 5 10 15

<210> 2924

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2924

Gln Pro Arg Glu Pro Gln Val

15

<210> 2925

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2925

Gln Val Ser Leu Thr Cys Leu

15

<210> 2926

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2926

Gln Val Tyr Thr Leu Pro Pro

15

<210> 2927

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2927

Arg Glu Pro Gln Val Tyr Thr

15

<210> 2928

<211> 21

<212>PRT

<213> Mus musculus

<400> 2928

Arg Gly Phe Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala

1 5 10 15

Ala Met Ala Ala Arg

20

<210> 2929

<211> 11

<212>PRT

<213> Homo sapiens

<400> 2929

Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe

1 5 10

<210> 2930

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2930

Arg Trp Gln Glu Gly Asn Val

15

<210> 2931

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2931

Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val

1 5 10 15

<210> 2932

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2932

Ser Cys Ser Val Met His Glu

15

<210> 2933

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2933

Ser Asp Gly Ser Phe Phe Leu

15

<210> 2934

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2934

Ser Phe Phe Leu Tyr Ser Lys

15

<210> 2935

<211> 27

<212>PRT

<213> Mus musculus

<400> 2935

Ser Gly Lys Pro Gly Ala His Val Thr Val Lys Lys Leu Phe Val Gly

1 5 10 15

Gly Ile Lys Glu Asp Thr Glu Glu His His Leu

20 25

<210> 2936

<211> 19

<212>PRT

<213> Homo sapiens

<400> 2936

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 2937

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2937

Ser Leu Ser Leu Ser Pro Gly

15

<210> 2938

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2938

Ser Leu Thr Cys Leu Val Lys

15

<210> 2939

<211> 10

<212>PRT

<213> Homo sapiens

<400> 2939

Ser Pro Arg Ser Gly Asp Leu Ser Val Tyr

1 5 10

<210> 2940

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2940

Ser Arg Glu Glu Met Thr Lys

15

<210> 2941

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2941

Ser Arg Trp Gln Glu Gly Asn

15

<210> 2942

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2942

Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp

1 5 10 15

<210> 2943

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2943

Ser Val Met His Glu Gly Leu

15

<210> 2944

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2944

Thr Lys Asn Gln Val Ser Leu

15

<210> 2945

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2945

Thr Leu Pro Pro Ser Arg Glu

15

<210> 2946

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2946

Val Glu Trp Gly Ser Asn Asp

15

<210> 2947

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2947

Val Phe Ser Cys Ser Val Met

15

<210> 2948

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2948

Val Met His Glu Gly Leu His

15

<210> 2949

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2949

Val Ser Leu Thr Cys Leu Val

15

<210> 2950

<211> 16

<212>PRT

<213> Homo sapiens

<400> 2950

Val Tyr Phe Cys Ala Ser Ser Phe Ser Thr Cys Ser Ala Asn Tyr Gly

1 5 10 15

<210> 2951

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2951

Val Tyr Thr Leu Pro Pro Ser

15

<210> 2952

<211> 7

<212>PRT

<213> Homo sapiens

<400> 2952

Trp Gln Glu Gly Asn Val Phe

15

<210> 2953

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2953

Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Pro Arg Gly Pro Pro

1 5 10 15

<210> 2954

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2954

Gly Ile Pro Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala

1 5 10 15

<210> 2955

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2955

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2956

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2956

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2957

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2957

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2958

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2958

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2959

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2959

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2960

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2960

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2961

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2961

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2962

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2962

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2963

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2963

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2964

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2964

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2965

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2965

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2966

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2966

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2967

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2967

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2968

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2968

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2969

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2969

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2970

<211> 20

<212>PRT

<213> Homo sapiens

<400> 2970

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala

20

<210> 2971

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2971

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala Asp

20

<210> 2972

<211> 38

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2972

Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser

1 5 10 15

Leu Arg Pro Ala Gly Gly Gly His Ser Thr Lys Arg Gly His Ala Lys

20 25 30

Ser Arg Pro Val Arg Gly

35

<210> 2973

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2973

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2974

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2974

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2975

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2975

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2976

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2976

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2977

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2977

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2978

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2978

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2979

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2979

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2980

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2980

Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu

1 5 10 15

Ala Pro

<210> 2981

<211> 24

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2981

Gly Phe Phe Cys Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu

1 5 10 15

Glu Ala Pro Cys Leu Arg Pro Ala

20

<210> 2982

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2982

Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys Leu

1 5 10 15

Val Thr

<210> 2983

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2983

Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys Leu

1 5 10 15

Val Thr

<210> 2984

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2984

Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys Leu

1 5 10 15

Val Thr

<210> 2985

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2985

His Cys Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly Ile

1 5 10 15

His Thr Cys Pro Leu

20

<210> 2986

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2986

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2987

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2987

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2988

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2988

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2989

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2989

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2990

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2990

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2991

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2991

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2992

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2992

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2993

<211> 15

<212>PRT

<213> Homo sapiens

<400> 2993

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly

1 5 10 15

<210> 2994

<211> 36

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 2994

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly His

1 5 10 15

Gln Cys His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Cys Gly

20 25 30

Arg Ser Gly Ser

35

<210> 2995

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2995

Ile Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu

1 5 10 15

Ile Lys

<210> 2996

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2996

Ile Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu

1 5 10 15

Ile Lys

<210> 2997

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2997

Ile Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu

1 5 10 15

Ile Lys

<210> 2998

<211> 18

<212>PRT

<213> Homo sapiens

<400> 2998

Ile Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu

1 5 10 15

Ile Lys

<210> 2999

<211> 22

<212>PRT

<213> Mus musculus

<400> 2999

Gln Thr Leu Asp His Asn Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys

1 5 10 15

Lys Leu Leu Lys Ile Met

20

<210> 3000

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3000

Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg

1 5 10 15

Lys Ala

<210> 3001

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3001

Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg

1 5 10 15

Lys Ala

<210> 3002

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3002

Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg

1 5 10 15

Lys Ala

<210> 3003

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3003

Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg

1 5 10 15

Lys Ala

<210> 3004

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3004

Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg

1 5 10 15

Lys Ala

<210> 3005

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3005

Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg

1 5 10 15

Lys Ala

<210> 3006

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3006

Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg His Pro Asp Glu

1 5 10 15

Ala Ala

<210> 3007

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3007

Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg His Pro Asp Glu

1 5 10 15

Ala Ala

<210> 3008

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3008

Ser Arg Ala Leu Ala Arg Glu Val Asp Leu Lys Asp Tyr Glu Asp Gln

1 5 10 15

Gln Lys

<210> 3009

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3009

Ser Arg Ala Leu Ala Arg Glu Val Asp Leu Lys Asp Tyr Glu Asp Gln

1 5 10 15

Gln Lys

<210> 3010

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3010

Ser Arg Ala Leu Ala Arg Glu Val Asp Leu Lys Asp Tyr Glu Asp Gln

1 5 10 15

Gln Lys

<210> 3011

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3011

Gly Asn Pro Gly Thr Asp Gly Ile Pro Gly Ala Lys Gly Ser Ala

1 5 10 15

<210> 3012

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3012

Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro

1 5 10 15

<210> 3013

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3013

Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser Pro Gly Pro Ala

1 5 10 15

<210> 3014

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3014

Gly Thr Pro Gly Ser Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro

1 5 10 15

<210> 3015

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3015

Ala Gly Glu Lys Val Thr Met

15

<210> 3016

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3016

Ala His Ile Trp Trp Asn Asp

15

<210> 3017

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3017

Ala Arg Met Arg Asp Gly Ala

15

<210> 3018

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3018

Ala Ser Thr Arg Glu Ser Gly

15

<210> 3019

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3019

Ala Val Tyr Phe Cys His Gln

15

<210> 3020

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3020

Ala Trp Phe Ala Tyr Trp Gly

15

<210> 3021

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3021

Ala Tyr Trp Gly Gln Gly Thr

15

<210> 3022

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3022

Cys Ala Arg Met Arg Asp Gly

15

<210> 3023

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3023

Cys His Gln Tyr Leu Ser Ser

15

<210> 3024

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3024

Cys Ser Phe Ser Gly Phe Ser

15

<210> 3025

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3025

Asp Gly Ala Trp Phe Ala Tyr

15

<210> 3026

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3026

Asp His Lys Asn Tyr Leu Ala

15

<210> 3027

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3027

Asp Leu Ala Val Tyr Phe Cys

15

<210> 3028

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3028

Glu Asp Leu Ala Val Tyr Phe

15

<210> 3029

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3029

Glu Ser Gly Val Pro Asp Arg

15

<210> 3030

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3030

Glu Trp Leu Ala His Ile Trp

15

<210> 3031

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3031

Phe Ala Tyr Trp Gly Gln Gly

15

<210> 3032

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3032

Phe Cys His Gln Tyr Leu Ser

15

<210> 3033

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3033

Phe Ser Gly Phe Ser Leu Thr

15

<210> 3034

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3034

Phe Ser Leu Thr Thr Tyr Gly

15

<210> 3035

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3035

Phe Tyr Asn Thr Val Leu Lys

15

<210> 3036

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3036

Gly Ala Trp Phe Ala Tyr Trp

15

<210> 3037

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3037

Gly Phe Ser Leu Thr Thr Tyr

15

<210> 3038

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3038

Gly Ile Gly Val Gly Trp Ile

15

<210> 3039

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3039

Gly Lys Gly Leu Glu Trp Leu

15

<210> 3040

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3040

Gly Leu Glu Trp Leu Ala His

15

<210> 3041

<211> 15

<212>PRT

<213> Bos taurus

<400> 3041

Gly Pro Ala Gly Pro Ala Gly Thr Ala Gly Ala Arg Gly Ala Pro

1 5 10 15

<210> 3042

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3042

Gly Gln Ser Pro Lys Leu Leu

15

<210> 3043

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3043

Gly Ser Gly Ser Gly Thr Asp

15

<210> 3044

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3044

Gly Ser Gly Thr Asp Phe Thr

15

<210> 3045

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3045

Gly Val Gly Trp Ile Arg Gln

15

<210> 3046

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3046

Gly Val Pro Asp Arg Phe Thr

15

<210> 3047

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3047

Gly Trp Ile Arg Gln Arg Ser

15

<210> 3048

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3048

His Ile Trp Trp Asn Asp Asn

15

<210> 3049

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3049

His Gln Tyr Leu Ser Ser Phe

15

<210> 3050

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3050

Ile Gly Val Gly Trp Ile Arg

15

<210> 3051

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3051

Ile Arg Gln Arg Ser Gly Lys

15

<210> 3052

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3052

Ile Trp Trp Asn Asp Asn Lys

15

<210> 3053

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3053

Lys Gly Leu Glu Trp Leu Ala

15

<210> 3054

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3054

Lys Leu Leu Ile Tyr Trp Ala

15

<210> 3055

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3055

Lys Asn Tyr Leu Ala Trp Tyr

15

<210> 3056

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3056

Lys Val Thr Met Thr Cys Lys

15

<210> 3057

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3057

Leu Ala His Ile Trp Trp Asn

15

<210> 3058

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3058

Leu Ala Val Tyr Phe Cys His

15

<210> 3059

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3059

Leu Glu Trp Leu Ala His Ile

15

<210> 3060

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3060

Leu Ile Tyr Trp Ala Ser Thr

15

<210> 3061

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3061

Leu Leu Ile Tyr Trp Ala Ser

15

<210> 3062

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3062

Leu Thr Cys Ser Phe Ser Gly

15

<210> 3063

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3063

Leu Tyr Ser Ser Asp His Lys

15

<210> 3064

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3064

Met Arg Asp Gly Ala Trp Phe

15

<210> 3065

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3065

Asn Tyr Leu Ala Trp Tyr Gln

15

<210> 3066

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3066

Pro Gly Gln Ser Pro Lys Leu

15

<210> 3067

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3067

Pro Lys Leu Leu Ile Tyr Trp

15

<210> 3068

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3068

Gln Ser Pro Lys Leu Leu Ile

15

<210> 3069

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3069

Gln Ser Val Leu Tyr Ser Ser

15

<210> 3070

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3070

Gln Thr Glu Asp Leu Ala Val

15

<210> 3071

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3071

Gln Tyr Leu Ser Ser Phe Thr

15

<210> 3072

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3072

Arg Asp Gly Ala Trp Phe Ala

15

<210> 3073

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3073

Arg Glu Ser Gly Val Pro Asp

15

<210> 3074

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3074

Arg Met Arg Asp Gly Ala Trp

15

<210> 3075

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3075

Ser Ala Gly Glu Lys Val Thr

15

<210> 3076

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3076

Ser Asp His Lys Asn Tyr Leu

15

<210> 3077

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3077

Ser Phe Ser Gly Phe Ser Leu

15

<210> 3078

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3078

Ser Gly Phe Ser Leu Thr Thr

15

<210> 3079

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3079

Ser Gly Ser Gly Thr Asp Phe

15

<210> 3080

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3080

Ser Gly Val Pro Asp Arg Phe

15

<210> 3081

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3081

Ser Leu Thr Thr Tyr Gly Ile

15

<210> 3082

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3082

Ser Pro Lys Leu Leu Ile Tyr

15

<210> 3083

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3083

Ser Gln Ser Val Leu Tyr Ser

15

<210> 3084

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3084

Ser Ser Gln Ser Val Leu Tyr

15

<210> 3085

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3085

Ser Thr Arg Glu Ser Gly Val

15

<210> 3086

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3086

Ser Val Leu Tyr Ser Ser Asp

15

<210> 3087

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3087

Thr Cys Ser Phe Ser Gly Phe

15

<210> 3088

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3088

Thr Glu Asp Leu Ala Val Tyr

15

<210> 3089

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3089

Thr Gly Ser Gly Ser Gly Thr

15

<210> 3090

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3090

Thr Met Thr Cys Lys Ser Ser

15

<210> 3091

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3091

Thr Arg Glu Ser Gly Val Pro

15

<210> 3092

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3092

Thr Thr Tyr Gly Ile Gly Val

15

<210> 3093

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3093

Thr Tyr Gly Ile Gly Val Gly

15

<210> 3094

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3094

Thr Tyr Tyr Cys Ala Arg Met

15

<210> 3095

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3095

Val Gly Trp Ile Arg Gln Arg

15

<210> 3096

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3096

Val Leu Tyr Ser Ser Asp His

15

<210> 3097

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3097

Val Pro Asp Arg Phe Thr Gly

15

<210> 3098

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3098

Val Thr Met Thr Cys Lys Ser

15

<210> 3099

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3099

Val Tyr Phe Cys His Gln Tyr

15

<210> 3100

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3100

Trp Ala Ser Thr Arg Glu Ser

15

<210> 3101

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3101

Trp Phe Ala Tyr Trp Gly Gln

15

<210> 3102

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3102

Trp Ile Arg Gln Arg Ser Gly

15

<210> 3103

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3103

Trp Leu Ala His Ile Trp Trp

15

<210> 3104

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3104

Trp Asn Asp Asn Lys Phe Tyr

15

<210> 3105

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3105

Trp Trp Asn Asp Asn Lys Phe

15

<210> 3106

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3106

Tyr Cys Ala Arg Met Arg Asp

15

<210> 3107

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3107

Tyr Phe Cys His Gln Tyr Leu

15

<210> 3108

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3108

Tyr Gly Ile Gly Val Gly Trp

15

<210> 3109

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3109

Tyr Leu Ala Trp Tyr Gln Gln

15

<210> 3110

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3110

Tyr Leu Ser Ser Phe Thr Phe

15

<210> 3111

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3111

Tyr Ser Ser Asp His Lys Asn

15

<210> 3112

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3112

Tyr Trp Ala Ser Thr Arg Glu

15

<210> 3113

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3113

Tyr Tyr Cys Ala Arg Met Arg

15

<210> 3114

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3114

Ala Ile Leu Thr Gly Gly Gln Val Ile Ser Glu Glu Gly Val Gly Leu

1 5 10 15

<210> 3115

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3115

Asp Arg Arg Lys Ala Met Leu Gln Asp Met Ala Ile Leu Thr Gly Gly

1 5 10 15

<210> 3116

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3116

Asp Val Glu Gly Glu Ala Leu Ser Thr Leu Val Val Asn Lys Ile Arg

1 5 10 15

<210> 3117

<211> 15

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3117

Glu Glu Gly Val Gly Leu Thr Leu Glu Asn Ala Asp Leu Ser Leu

1 5 10 15

<210> 3118

<211> 11

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3118

Val Val Asn Lys Ile Arg Gly Thr Phe Lys Ser

1 5 10

<210> 3119

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3119

Val Val Asn Lys Ile Arg Gly Thr Phe Lys Ser Val Ala Val Lys Ala

1 5 10 15

<210> 3120

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3120

Gln Asp Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser

1 5 10

<210> 3121

<211> 8

<212>PRT

<213> Streptococcus pyogenes

<400> 3121

Leu Thr Ser Arg Pro Ala His Gly

15

<210> 3122

<211> 12

<212>PRT

<213> Mus musculus

<400> 3122

Leu Tyr Phe Cys Ala Ala Arg Ser Asn Tyr Gln Leu

1 5 10

<210> 3123

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 3123

Ala Leu Ser Thr Leu Val Leu Asn Arg Leu Lys Val Gly Leu Gln

1 5 10 15

<210> 3124

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3124

Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser

1 5 10 15

<210> 3125

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3125

Gly Glu Ala Leu Ser Thr Leu Val Leu Asn Arg Leu Lys Val Gly

1 5 10 15

<210> 3126

<211> 15

<212>PRT

<213> Mycobacterium

<400> 3126

Gly Glu Ala Leu Ser Thr Leu Val Val Asn Lys Ile Arg Gly Thr

1 5 10 15

<210> 3127

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3127

Lys Cys Glu Phe Gln Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys

1 5 10 15

<210> 3128

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3128

Val Ala Ser Leu Leu Thr Thr Ala Glu Val Val Val Thr Glu Ile

1 5 10 15

<210> 3129

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 3129

Lys Glu Arg Tyr Ser Thr Leu Tyr Ile Ser Asn Ala Gln Val Glu

1 5 10 15

<210> 3130

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3130

Ala Val Cys Arg Thr Ser Met Cys Ser Ile Gln Ser Ala Pro Pro

1 5 10 15

<210> 3131

<211> 15

<212>PRT

<213> Mus musculus

<400> 3131

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Asp Gln Gly Pro Lys

1 5 10 15

<210> 3132

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 3132

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

<210> 3133

<211> 8

<212>PRT

<213> Rattus norvegicus

<400> 3133

Ile Ala Gly Phe Lys Gly Glu Gln

15

<210> 3134

<211> 15

<212>PRT

<213> Bos taurus

<400> 3134

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

<210> 3135

<211> 15

<212>PRT

<213> Bos taurus

<400> 3135

Gly Glu Pro Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys

1 5 10 15

<210> 3136

<211> 26

<212>PRT

<213> Homo sapiens

<400> 3136

Ala Gly Ala Ala Arg Asp Ala Leu Gln Gly Phe Lys Ile Thr Gln Asn

1 5 10 15

Asn Ala Met Lys Ile Ser Phe Ala Lys Lys

20 25

<210> 3137

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3137

Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly Trp

1 5 10 15

Thr Ser Arg Trp Ile Glu Ser Lys

20

<210> 3138

<211> 23

<212>PRT

<213> Homo sapiens

<400> 3138

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Gly Pro Arg Arg

20

<210> 3139

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3139

Lys Ala Leu Ser Val Glu Thr Glu Lys Leu Leu Lys Tyr Leu Glu Ala

1 5 10 15

Val

<210> 3140

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3140

Lys Met Thr Leu Lys Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser

1 5 10 15

Ile Arg Gly Asn Arg Ile Arg Tyr

20

<210> 3141

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3141

Lys Pro Lys Ala Ala Lys Pro Lys Lys Ala Ala Ala Lys Lys Lys

1 5 10 15

<210> 3142

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3142

Met Ala Val Pro Glu Thr Arg Pro Asn His Thr

1 5 10

<210> 3143

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3143

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr

1 5 10 15

Ile Glu Leu Lys

20

<210> 3144

<211> 17

<212>PRT

<213> Enterovirus A

<400> 3144

Met Val Thr Ser Thr Ile Thr Glu Lys Leu Leu Lys Asn Leu Val Lys

1 5 10 15

Ile

<210> 3145

<211> 21

<212>PRT

<213> Mus musculus

<400> 3145

Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr

1 5 10 15

Ala Phe Ile Glu Tyr

20

<210> 3146

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3146

Ser Gln Phe Gly Gln Ile Leu Asp Ile Leu Val Ser Arg Ser Leu Lys

1 5 10 15

Met Arg Gly Gln Ala Phe Val Ile

20

<210> 3147

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3147

Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10 15

Leu Ser His Leu Lys Pro

20

<210> 3148

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3148

Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser

1 5 10 15

Ile Glu Ser Ala

20

<210> 3149

<211> 37

<212>PRT

<213> Homo sapiens

<400> 3149

Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

20 25 30

Gly Gly Pro Arg Arg

35

<210> 3150

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3150

Ala Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe

1 5 10 15

<210> 3151

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3151

Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10 15

Leu Ser His Leu Lys Pro

20

<210> 3152

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3152

Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10 15

Leu Ser His Leu Lys Pro

20

<210> 3153

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3153

Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Gly Pro Arg Arg

20 25

<210> 3154

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3154

Arg Lys Gly His Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile

1 5 10 15

Trp Leu

<210> 3155

<211> 22

<212>PRT

<213> Mus musculus

<400> 3155

Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly Ser Leu

20

<210> 3156

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3156

Gly Lys Ala Leu Cys Trp Val Cys Ala Gln Ser Arg Lys His Arg Asp

1 5 10 15

<210> 3157

<211> 15

<212>PRT

<213> Human endogenous retrovirus

<400> 3157

Gly Lys Thr Cys Pro Lys Glu Ile Pro Lys Gly Ser Lys Asn Thr

1 5 10 15

<210> 3158

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3158

Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His Ile Thr Leu Asp

1 5 10 15

<210> 3159

<211> 49

<212>PRT

<213> Mus musculus

<400> 3159

Pro Leu Phe Pro Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

20 25 30

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Ser Leu Ile Tyr

35 40 45

Ile

<210> 3160

<211> 9

<212>PRT

<213> Mycobacterium bovis

<400> 3160

Lys Pro Leu Leu Ile Ile Ala Glu Asp

15

<210> 3161

<211> 10

<212>PRT

<213> Human adenovirus

<400> 3161

Phe Trp Arg Phe Leu Trp Gly Ser Ser Gln

1 5 10

<210> 3162

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3162

Met Ser Lys Thr Glu Trp Asn Ala Ser Gln Leu Pro Arg Leu Gly Gly

1 5 10 15

Lys Glu Asp Arg

20

<210> 3163

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3163

Met Ser Lys Thr Glu Trp Asn Ala Ser Gln Ser Arg Phe Gly Trp Phe

1 5 10 15

Glu Asn Lys Glu

20

<210> 3164

<211> 11

<212>PRT

<213> Influenza A virus

<400> 3164

Thr Leu Gln Arg Phe Ala Trp Gly Ser Ser Asn

1 5 10

<210> 3165

<211> 50

<212>PRT

<213> Homo sapiens

<400> 3165

Gly Tyr Gly Lys Ile Asn Lys Lys Arg Ile Ala Leu Thr Asp Asn Ala

1 5 10 15

Leu Ile Ala Arg Ser Leu Gly Lys Tyr Gly Ile Ile Cys Met Glu Asp

20 25 30

Leu Ile His Glu Ile Tyr Thr Val Gly Lys Arg Phe Lys Glu Ala Asn

35 40 45

Asn Phe

50

<210> 3166

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3166

Arg Met Ala Arg Met Ala Arg Lys Ala Gly Asn Phe Tyr Val Pro Ala

1 5 10 15

Glu Pro Lys

<210> 3167

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3167

Ala Ala Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His

1 5 10 15

<210> 3168

<211> 15

<212>PRT

<213> Proteus mirabilis

<400> 3168

Phe Ala Glu Ser Arg Ile Arg Arg Glu Thr Ile Ala Ala Glu Asp

1 5 10 15

<210> 3169

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3169

Gly Ser Leu Asp Ser Leu Arg Arg Glu Ile Glu Gln Met Arg Arg

1 5 10 15

<210> 3170

<211> 15

<212>PRT

<213> Proteus mirabilis

<400> 3170

Leu Gly Ser Ser Glu Ser Arg Arg Ala Leu Gln Asp Ser Gln Arg

1 5 10 15

<210> 3171

<211> 5

<212>PRT

<213> Homo sapiens

<400> 3171

Leu Arg Arg Glu Ile

15

<210> 3172

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3172

Ser Gln Lys Asp Leu Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr

1 5 10 15

<210> 3173

<211> 21

<212>PRT

<213> Bos taurus

<400> 3173

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro

1 5 10 15

Arg Lys Gln Leu Ala

20

<210> 3174

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3174

Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr Lys Leu Thr

1 5 10 15

<210> 3175

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3175

Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg Ala Val Leu

1 5 10 15

<210> 3176

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3176

Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp

1 5 10 15

<210> 3177

<211> 21

<212>PRT

<213> Bos taurus

<400> 3177

Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile Pro

1 5 10 15

Arg His Leu Gln Leu

20

<210> 3178

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3178

Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu Leu Asp Gly

1 5 10 15

<210> 3179

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3179

Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala

1 5 10 15

<210> 3180

<211> 16

<212>PRT

<213> Bos taurus

<400> 3180

Pro Ala Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr

1 5 10 15

<210> 3181

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3181

Val Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr

1 5 10

<210> 3182

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3182

Ala Ser Ala Ala Arg Leu Thr Met Met Trp

1 5 10

<210> 3183

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3183

Leu Phe Lys Pro Pro Lys Tyr His Pro Asp Val Pro Tyr Val Lys Arg

1 5 10 15

<210> 3184

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3184

Leu Arg Lys Phe Lys Asn Ile Ser Tyr Phe Pro Gly Lys Leu Arg

1 5 10 15

<210> 3185

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3185

Ser Lys Leu Ile Lys Ile Phe Gln Asp His Pro Leu Gln Lys Thr Tyr

1 5 10 15

Asn

<210> 3186

<211> 15

<212>PRT

<213> Proteus mirabilis

<400> 3186

Ala Ser Arg Glu Thr Lys Glu Leu Arg Gln Glu Glu Arg Gln Pro

1 5 10 15

<210> 3187

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3187

Asn Gly Ser Ser Glu Ser Arg Arg Ala Leu Gln Asp Ser Gln Arg

1 5 10 15

<210> 3188

<211> 16

<212>PRT

<213> Rattus norvegicus

<400> 3188

Tyr Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly

1 5 10 15

<210> 3189

<211> 15

<212>PRT

<213> Human herpes virus

<400> 3189

Gln Lys Arg Ala Ala Gln Arg Ala Ala Gly Pro Ser Val Ala Ser

1 5 10 15

<210> 3190

<211> 15

<212>PRT

<213> Lactococcus lactis

<400> 3190

Gln Lys Arg Ala Ala Tyr Asp Gln Tyr Gly Glu Ala Gly Ala Asn

1 5 10 15

<210> 3191

<211> 15

<212>PRT

<213> Brucella ovis

<400> 3191

Gln Lys Arg Ala Ala Tyr Asp Arg Phe Gly His Ala Ala Phe Glu

1 5 10 15

<210> 3192

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3192

Leu Pro Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser

1 5 10 15

Leu Pro Leu

<210> 3193

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3193

Leu Pro Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser

1 5 10 15

Leu Pro Leu

<210> 3194

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3194

Ser Ser Arg Ser Tyr Val Thr Thr Ser Thr Arg Thr Tyr Ser Leu Gly

1 5 10 15

Ser Ala Leu

<210> 3195

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3195

Ala Leu Pro Pro Pro Tyr Met

15

<210> 3196

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3196

Glu Ser Met Pro Ala Leu Ser

15

<210> 3197

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3197

Gly Thr Asn Thr Ala Gln Lys

15

<210> 3198

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3198

Ile Pro Asn Ser Thr His Thr

15

<210> 3199

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3199

Lys Trp Ser Phe Thr Pro Pro

15

<210> 3200

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3200

Leu His Ser Asp Ala Arg Asp

15

<210> 3201

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3201

Leu Asn Thr Thr Leu Lys Val

15

<210> 3202

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3202

Leu Pro Tyr Lys Leu Thr Gln

15

<210> 3203

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3203

Met Val Pro Glu Leu Thr Glu

15

<210> 3204

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3204

Pro Gly Pro Ser Thr Thr Ser

15

<210> 3205

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3205

Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile Lys Leu

1 5 10 15

<210> 3206

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3206

Ala Ala Lys Pro Lys Thr Ala Lys Pro Lys Ala Ala Lys Pro Lys Lys

1 5 10 15

<210> 3207

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3207

Ala Gly Ala Ala Lys Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu

1 5 10 15

<210> 3208

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3208

Ala Lys Lys Ala Gly Ala Ala Lys Ala Lys Lys Pro Ala Gly Ala Ala

1 5 10 15

<210> 3209

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3209

Ala Pro Lys Ser Pro Ala Lys Ala Lys Ala Val Lys Pro Lys Ala Ala

1 5 10 15

<210> 3210

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3210

Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys

1 5 10 15

<210> 3211

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3211

Glu Lys Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala

1 5 10 15

<210> 3212

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3212

Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln

1 5 10 15

<210> 3213

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3213

Ile Trp Tyr Ile Asn Cys Phe Ala Cys Glu Thr His Ala Met Leu

1 5 10 15

<210> 3214

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3214

Ile Trp Tyr Ile Asn Cys Phe Val Cys Glu Thr His Ala Met Leu

1 5 10 15

<210> 3215

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3215

Ile Trp Tyr Ile Ser Cys Phe Gly Cys Glu Thr His Ala Met Leu

1 5 10 15

<210> 3216

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3216

Ile Trp Tyr Ile Thr Cys Phe Gly Cys Glu Thr His Ala Met Leu

1 5 10 15

<210> 3217

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3217

Lys Ala Lys Lys Pro Ala Ala Ala Ala Gly Ala Lys Lys Ala Lys Ser

1 5 10 15

<210> 3218

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3218

Lys Glu Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys

1 5 10 15

Lys

<210> 3219

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3219

Lys Leu Asn Lys Lys Ala Ala Ser Gly Glu Ala Lys Pro Lys Ala Lys

1 5 10 15

<210> 3220

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3220

Lys Ser Pro Lys Lys Ala Lys Ala Ala Lys Pro Lys Lys Ala Pro Lys

1 5 10 15

<210> 3221

<211> 15

<212>PRT

<213> Gallus gallus

<400> 3221

Lys Ser Arg Lys Ala Ser Lys Ala Lys Lys Val Lys Arg Ser Lys

1 5 10 15

<210> 3222

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3222

Leu Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn

1 5 10 15

<210> 3223

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3223

Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Ala Thr Gly Ala Ala Thr

1 5 10 15

<210> 3224

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3224

Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys Ala Leu Ala Ala Ala

1 5 10 15

<210> 3225

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3225

Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu Lys

1 5 10 15

<210> 3226

<211> 16

<212>PRT

<213> Gallus gallus

<400> 3226

Ser Lys Pro Arg Ala Lys Ser Gly Ala Arg Lys Ser Pro Lys Lys Lys

1 5 10 15

<210> 3227

<211> 31

<212>PRT

<213> Gallus gallus

<400> 3227

Thr Glu Ser Leu Val Leu Ser Pro Ala Pro Ala Lys Pro Lys Arg Val

1 5 10 15

Lys Ala Ser Arg Arg Ser Ala Ser His Pro Thr Tyr Ser Glu Met

20 25 30

<210> 3228

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3228

Val Ser Glu Leu Ile Thr Lys Ala Val Ala Ala Ser Lys Glu Arg Ser

1 5 10 15

<210> 3229

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3229

Cys Ser Ala Gly Trp Leu Ala Asp Arg Ser Val Arg Tyr Pro Ile Ser

1 5 10 15

Lys Ala

<210> 3230

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3230

Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro

1 5 10 15

<210> 3231

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3231

Lys Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg

1 5 10 15

<210> 3232

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3232

Leu Ala Asp Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn

1 5 10 15

Cys Gly

<210> 3233

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3233

Leu Gln Lys Arg Ser Ser Arg His Pro Arg Arg Ser Arg Pro Ser Thr

1 5 10 15

<210> 3234

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3234

Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp Arg Ser

1 5 10 15

Val Arg

<210> 3235

<211> 15

<212>PRT

<213> Yersinia enterocolitica

<400> 3235

Gln Lys Gln Leu Gly Trp Gln Ala Gly Met Asp Glu Ala Arg Thr

1 5 10 15

<210> 3236

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3236

Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr Ile Pro

1 5 10 15

<210> 3237

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3237

Arg Val Leu Leu Gly Thr Ser Leu Thr Ile Pro Cys Tyr Phe Ile Asp

1 5 10 15

<210> 3238

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3238

Arg Val Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro

1 5 10 15

<210> 3239

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3239

Thr Thr Gly His Val Tyr Leu Ala Trp Gln Ala Gly Met Asp Met Cys

1 5 10 15

Ser Ala

<210> 3240

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3240

Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser Ala Tyr Gln Asp Lys

1 5 10 15

Val

<210> 3241

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3241

Ala Ser Ser Leu Leu Ala Ser Ser Pro

15

<210> 3242

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3242

Ile Pro Phe Pro Thr Leu Phe Ala Pro

15

<210> 3243

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3243

Pro His Glu Ser Asp Ala Thr Val Arg

15

<210> 3244

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3244

Pro His Asn Arg Gln Glu Ser Pro Ala

15

<210> 3245

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3245

Pro Pro Leu Lys Pro Val Ile Asp Glu

15

<210> 3246

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3246

Pro Ser Pro Ser Leu Ser His Pro Leu

15

<210> 3247

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3247

Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val

1 5 10 15

<210> 3248

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3248

Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr

1 5 10 15

<210> 3249

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3249

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr

1 5 10 15

<210> 3250

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3250

Glu Val Phe Ile Ser Ala Pro Arg

15

<210> 3251

<211> 21

<212>PRT

<213> Human T-lymphotropic virus

<400> 3251

Pro Pro Pro Pro Ser Ser Pro Thr His Asp Pro Pro Asp Ser Asp Pro

1 5 10 15

Gln Ile Pro Pro Pro

20

<210> 3252

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3252

Pro Gln Ile Val Pro Glu Pro Met

15

<210> 3253

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3253

Pro Thr Arg Ala Pro Ser Gly Pro Arg Pro Pro Ser Arg Ser Gln Ala

1 5 10 15

Gln Thr Pro Pro Arg

20

<210> 3254

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3254

Ala Thr Glu Gly Arg Val Arg Val Asn Ser Ala Tyr

1 5 10

<210> 3255

<211> 6

<212>PRT

<213> Homo sapiens

<400> 3255

Leu Thr Ser Arg Pro Ala

15

<210> 3256

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3256

Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser Ala

1 5 10 15

Tyr Gln Asp Lys

20

<210> 3257

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3257

Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser Ala

1 5 10 15

Tyr Gln Asp Lys

20

<210> 3258

<211> 18

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3258

Gly Pro Pro Gly Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly

1 5 10 15

Pro Pro

<210> 3259

<211> 18

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3259

Gly Pro Pro Gly Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly

1 5 10 15

Pro Pro

<210> 3260

<211> 37

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3260

Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly

1 5 10 15

Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Pro Gly Pro

20 25 30

Pro Gly Ala Cys Ala

35

<210> 3261

<211> 206

<212>PRT

<213> Homo sapiens

<400> 3261

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

1 5 10 15

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu

20 25 30

Asp Pro Gln Val Gln Phe Asn Trp Tyr Val Asp Gly Val Gln Val His

35 40 45

Asn Ala Lys Thr Lys Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg

50 55 60

Val Val Ser Val Leu Thr Val Leu His Gln Asn Trp Leu Asp Gly Lys

65 70 75 80

Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu

85 90 95

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

100 105 110

Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu

115 120 125

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

130 135 140

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

145 150 155 160

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp

165 170 175

Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His

180 185 190

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu

195 200 205

<210> 3262

<211> 9

<212>PRT

<213> Burkholderia fungorum

<400> 3262

Arg Ala Gly Thr Asp Glu Gly Phe Gly

15

<210> 3263

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3263

Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu Gly Lys His Leu

1 5 10 15

Gly Ile Pro Lys

20

<210> 3264

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3264

Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly Ser Lys

1 5 10 15

Ala

<210> 3265

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3265

Ala Asn Gly Trp Gly Val Met Val Ser His Arg Ser Gly Glu Thr Glu

1 5 10 15

Asp Thr

<210> 3266

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3266

Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser

1 5 10 15

Cys Tyr Lys Leu

20

<210> 3267

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3267

Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly Leu Gln

1 5 10 15

Cys Thr Phe Ile

20

<210> 3268

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3268

Glu Lys Gly Val Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn

1 5 10 15

Ser Glu

<210> 3269

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3269

Glu Pro Leu Gly Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr

1 5 10 15

His Ile Arg His

20

<210> 3270

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3270

Glu Thr Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln

1 5 10

<210> 3271

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3271

Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile Thr

1 5 10

<210> 3272

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3272

Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu Asp Thr Ser Asn

1 5 10 15

Leu Glu Leu Pro

20

<210> 3273

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3273

Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala Leu Leu Phe Glu

1 5 10 15

Gly Ile Lys Lys

20

<210> 3274

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3274

Phe Arg Ser Gly Lys Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro

1 5 10 15

Ser Arg Tyr

<210> 3275

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3275

Gly Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala

1 5 10

<210> 3276

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3276

Gly Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala

1 5 10

<210> 3277

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3277

Ile Gln Val Val Gly Asp Asp Leu Thr Val Thr Asn Pro Lys Arg Ile

1 5 10 15

Ala Lys Ala

<210> 3278

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3278

Lys Ala Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr

1 5 10 15

Tyr Gly Pro Lys

20

<210> 3279

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3279

Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys

1 5 10

<210> 3280

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3280

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3281

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3281

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3282

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3282

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3283

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3283

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3284

<211> 17

<212>PRT

<213> Porphyromonas gingivalis

<400> 3284

Lys Ile Ile Gly Arg Glu Ile Leu Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3285

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3285

Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile

1 5 10 15

Cys Pro Glu Glu

20

<210> 3286

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3286

Leu Leu Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln

1 5 10 15

Asp Ser Val Val

20

<210> 3287

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3287

Leu Val Asn Cys Asp Arg Asp Asn Leu Glu Ser Ser Ala Met Asp Cys

1 5 10 15

Glu Asp Asp Glu

20

<210> 3288

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3288

Asn Asp Phe Phe Thr Tyr His Ile Arg His Gly Glu Val His Cys Gly

1 5 10 15

Thr Asn Val Arg

20

<210> 3289

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3289

Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu

1 5 10 15

Lys Asn

<210> 3290

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3290

Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn Cys

1 5 10 15

Leu Leu

<210> 3291

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3291

Pro Phe Gly Pro Val Ile Asn Gly Arg Cys Cys Leu Glu Glu Lys Val

1 5 10 15

Cys Ser Leu Leu

20

<210> 3292

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3292

Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe

1 5 10 15

Pro Asp Thr Asp

20

<210> 3293

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3293

Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile

1 5 10 15

Thr

<210> 3294

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3294

Ser Ile Asn Ala Ser Pro Gly Val Val Val Asp Ile Ala His Ser Pro

1 5 10 15

Pro Ala Lys Lys

20

<210> 3295

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3295

Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg Ala Ala Val Pro Ser

1 5 10 15

Gly

<210> 3296

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3296

Val Glu Ala Leu Ala Phe Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr

1 5 10 15

Leu Thr Ile Ser

20

<210> 3297

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3297

Val Leu Asp Ser Glu Asp Leu Gln Asp Met Ser Leu Met Thr Leu Ser

1 5 10 15

Thr Lys Thr Pro

20

<210> 3298

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3298

Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys Cys Ser

1 5 10 15

Val Val Leu Gly

20

<210> 3299

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3299

Trp Gly Pro Cys Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg

1 5 10 15

Asp Asn Leu Glu

20

<210> 3300

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3300

Tyr Glu Ala Leu Glu Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly

1 5 10 15

Lys Gly Val Ser Lys

20

<210> 3301

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3301

Ala Cys Leu Asp Val Gly Ala Val Ile Ala Thr Pro Glu Gln Leu Phe

1 5 10 15

Ala Ala Tyr Glu Asp Gly Phe Glu Gln

20 25

<210> 3302

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3302

Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu Gln Asn Ser Ala Ile Ile

1 5 10 15

Ala Thr Pro Glu Gln Leu Gln Ala

20

<210> 3303

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3303

Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu

1 5 10 15

Ala Asp Gln Thr Val Arg Tyr Pro Ile

20 25

<210> 3304

<211> 25

<212>PRT

<213> Mus musculus

<400> 3304

Phe Ala Ala Tyr Glu Asp Gly Phe Glu Gln Cys Asp Ala Gly Trp Leu

1 5 10 15

Ser Asp Gln Thr Val Arg Tyr Pro Ile

20 25

<210> 3305

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3305

Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val Arg His

1 5 10 15

Pro Val Thr Val Ala Arg Ala Gln Cys

20 25

<210> 3306

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3306

Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro

1 5 10 15

Pro Asp Ser Arg Phe Asp Ala Tyr Cys

20 25

<210> 3307

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3307

His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro

1 5 10 15

Ile His Thr Pro Arg Glu Gly Cys

20

<210> 3308

<211> 23

<212>PRT

<213> Mus musculus

<400> 3308

Ile Ala Ser Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly Phe Glu

1 5 10 15

Gln Cys Asp Ala Gly Trp Leu

20

<210> 3309

<211> 23

<212>PRT

<213> Mus musculus

<400> 3309

Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr Glu Asp Gly Phe His

1 5 10 15

Gln Cys Asp Ala Gly Trp Leu

20

<210> 3310

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3310

Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr Glu Asp Gly Phe His

1 5 10 15

Gln Cys Asp Ala Gly Trp Leu Ala

20

<210> 3311

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3311

Leu Ala Asp Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn

1 5 10 15

Cys Gly Gly Asn Leu Leu Gly Val

20

<210> 3312

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3312

Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val Arg Gly Ser Leu

1 5 10 15

Ser Gly Lys Val Ser Leu Pro Cys His

20 25

<210> 3313

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3313

Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys Asp Glu Phe

1 5 10 15

Pro Gly Val Arg Thr Tyr Gly Ile

20

<210> 3314

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3314

Pro Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Arg Arg Met Ser

1 5 10 15

Asp Leu Ser Val Ile Gly His Pro Ile

20 25

<210> 3315

<211> 25

<212>PRT

<213> Mus musculus

<400> 3315

Gln Ala Ala Tyr Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu

1 5 10 15

Ala Asp Gln Thr Val Arg Tyr Pro Ile

20 25

<210> 3316

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3316

Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg Asn Gly Phe

1 5 10 15

Asp Gln Cys Asp Tyr Gly Trp Leu Ser

20 25

<210> 3317

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3317

Arg Val Ser Lys Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly

1 5 10 15

Arg Val Arg Val Asn Ser Ala Tyr

20

<210> 3318

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3318

Ser Asp Leu Ser Val Ile Gly His Pro Ile Asp Ser Glu

1 5 10

<210> 3319

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3319

Tyr Leu Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu

1 5 10 15

Ala Asp Arg Ser Val Arg Tyr Pro

20

<210> 3320

<211> 20

<212>PRT

<213> Mus musculus

<400> 3320

His Gln Cys His Gln Glu Ser Thr Gly Arg Ser Arg Gly Arg Cys Gly

1 5 10 15

Arg Ser Gly Ser

20

<210> 3321

<211> 21

<212>PRT

<213> Mus musculus

<400> 3321

His Gln Cys His Gln Glu Ser Thr Lys Gly Lys Ser Lys Gly Lys Cys

1 5 10 15

Gly Lys Ser Gly Ser

20

<210> 3322

<211> 21

<212>PRT

<213> Mus musculus

<400> 3322

His Gln Cys His Gln Glu Ser Thr Lys Gly Lys Ser Lys Gly Lys Cys

1 5 10 15

Gly Lys Ser Gly Ser

20

<210> 3323

<211> 19

<212>PRT

<213> Mus musculus

<400> 3323

Ser His Gln Glu Ser Thr Lys Gly Lys Ser Lys Gly Lys Ser Gly Lys

1 5 10 15

Ser Gly Ser

<210> 3324

<211> 19

<212>PRT

<213> Mus musculus

<400> 3324

Ser His Gln Glu Ser Thr Lys Gly Lys Ser Lys Gly Lys Ser Gly Lys

1 5 10 15

Ser Gly Ser

<210> 3325

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3325

Cys Ser Val Met His Glu Ala

15

<210> 3326

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3326

Phe Arg Val Val Ser Val Leu

15

<210> 3327

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3327

His Asn Ala Lys Thr Lys Leu

15

<210> 3328

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3328

Met His Glu Ala Leu His Asn

15

<210> 3329

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3329

Pro Arg Glu Gln Gln Phe Asn

15

<210> 3330

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3330

Gln Gln Phe Asn Ser Thr Phe

15

<210> 3331

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3331

Ser Val Met His Glu Ala Leu

15

<210> 3332

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3332

Thr Phe Arg Val Val Ser Val

15

<210> 3333

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3333

Val Leu Thr Val Leu His Gln

15

<210> 3334

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3334

Val Met His Glu Ala Leu His

15

<210> 3335

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3335

Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro

1 5 10 15

<210> 3336

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3336

Asp Ser Pro Gly Ser Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp

1 5 10 15

<210> 3337

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3337

Glu Gln Ser Ala Asp Ser Ser Arg His Ser Gly Ser Gly His

1 5 10

<210> 3338

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3338

Glu Arg Gly Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser

1 5 10 15

<210> 3339

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3339

Glu Ser Ser Arg Asp Gly Ser Arg His Pro Arg Ser His Asp

1 5 10

<210> 3340

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3340

Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys Val Thr Ser Gly

1 5 10 15

<210> 3341

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3341

Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys Asp Ser

1 5 10 15

<210> 3342

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3342

Gly Thr Phe Glu Glu Val Ser Gly Asn Val Ser Pro Gly Thr Arg

1 5 10 15

<210> 3343

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3343

Ile Glu Val Leu Lys Arg Lys Val Ile Glu Lys Val Gln His Ile

1 5 10 15

<210> 3344

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3344

Leu Glu Asn Leu Arg Ser Lys Ile Gln Lys Leu Glu Ser Asp Val

1 5 10 15

<210> 3345

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3345

Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp Glu Leu

1 5 10 15

<210> 3346

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3346

Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly Gly

1 5 10 15

<210> 3347

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3347

Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp Gly

1 5 10 15

<210> 3348

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3348

Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln Met Arg Met Glu

1 5 10 15

<210> 3349

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3349

Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp Trp Tyr

1 5 10 15

<210> 3350

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3350

Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg

1 5 10 15

<210> 3351

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3351

Gln Asn Pro Gly Ser Pro Arg Pro Gly Ser Thr Gly Thr Trp Asn

1 5 10 15

<210> 3352

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3352

Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly Ile His Thr Ser

1 5 10 15

<210> 3353

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3353

Arg Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg

1 5 10 15

<210> 3354

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3354

Ser Cys Ser Arg Ala Leu Ala Arg Glu Val Asp Leu Lys Asp Tyr

1 5 10 15

<210> 3355

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3355

Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp

1 5 10 15

<210> 3356

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3356

Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg His Pro Asp

1 5 10 15

<210> 3357

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3357

Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser

1 5 10 15

<210> 3358

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3358

Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys

1 5 10 15

<210> 3359

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3359

Ser Tyr Asn Arg Gly Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys

1 5 10 15

<210> 3360

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3360

Thr Gly Ser Ser Thr Gly Gly Arg Gln Gly Ser His His Glu

1 5 10

<210> 3361

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3361

Thr Ile His Ala His Pro Gly Ser Arg Arg Gly Gly Arg His Gly Tyr

1 5 10 15

His His

<210> 3362

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3362

Thr Thr Arg Arg Ser Cys Ser Lys Thr Val Thr Lys Thr Val Ile

1 5 10 15

<210> 3363

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3363

Val Asp Ile Asp Ile Lys Ile Arg Ser Cys Arg Gly Ser Cys Ser

1 5 10 15

<210> 3364

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3364

Val Ile Gln Asn Arg Gln Asp Gly Ser Val Asp Phe Gly Arg Lys

1 5 10 15

<210> 3365

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3365

Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr

1 5 10 15

<210> 3366

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3366

Trp Tyr Ser Met Arg Lys Met Ser Met Lys Ile Arg Pro Phe Phe

1 5 10 15

<210> 3367

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3367

Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln

1 5 10 15

<210> 3368

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3368

Gly Lys Leu Tyr Gly Ile Arg Asp Val Arg Ser Thr Arg Asp Arg

1 5 10 15

<210> 3369

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3369

Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr

1 5 10 15

<210> 3370

<211> 20

<212>PRT

<213> Porphyromonas gingivalis

<400> 3370

Thr Leu Val Val Asn Arg Leu Arg Gly Ser Leu Lys Ile Cys Ala Val

1 5 10 15

Lys Ala Pro Gly

20

<210> 3371

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3371

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3372

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3372

Ala Asn Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly

1 5 10 15

Asn Ala Leu

<210> 3373

<211> 30

<212>PRT

<213> Homo sapiens

<400> 3373

Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala

1 5 10 15

Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr

20 25 30

<210> 3374

<211> 30

<212>PRT

<213> Homo sapiens

<400> 3374

Lys Tyr Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala

1 5 10 15

Leu Met Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr

20 25 30

<210> 3375

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3375

Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met Asp Gly Ala Ser

1 5 10 15

Gln Leu

<210> 3376

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3376

Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met Asp Gly Ala Ser

1 5 10 15

Gln Leu

<210> 3377

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3377

Leu Val Val Tyr Pro Trp Thr Gln Arg Phe

1 5 10

<210> 3378

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3378

Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe Lys Thr Pro Arg Gly

1 5 10 15

Pro Val

<210> 3379

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3379

Arg Leu Pro Ile Ile Asp Val Ala Pro Leu Asp Val Gly Ala Pro Asp

1 5 10 15

<210> 3380

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3380

Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr

1 5 10 15

<210> 3381

<211> 9

<212>PRT

<213> Human herpes virus

<400> 3381

Gly Gln Ser Arg Gly Gln Ser Arg Gly

15

<210> 3382

<211> 21

<212>PRT

<213> Human herpes virus

<400> 3382

Gly Gln Ser Arg Gly Gln Ser Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Lys Gly

20

<210> 3383

<211> 15

<212>PRT

<213> Human herpes virus

<400> 3383

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Gly Arg Gly

1 5 10 15

<210> 3384

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3384

Asp Leu Leu Pro Ser Arg Asp Arg

15

<210> 3385

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3385

Asp Leu Leu Pro Ser Arg Asp Arg

15

<210> 3386

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3386

Asp Arg Gln His Leu Pro Leu Ile Lys

15

<210> 3387

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3387

Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro Pro Ile Ser Gly Gly

1 5 10 15

Gly Tyr Arg Ala Arg Pro Ala Lys

20

<210> 3388

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3388

Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro Pro Ile Ser Gly Gly

1 5 10 15

Gly Tyr Arg Ala Arg Pro Ala Lys

20

<210> 3389

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3389

Glu Ser Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly

1 5 10 15

Lys

<210> 3390

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3390

Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile

1 5 10 15

<210> 3391

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3391

Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile

1 5 10 15

<210> 3392

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3392

Lys Glu Ser Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg

1 5 10 15

Gly

<210> 3393

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3393

Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly Asp Ser Thr Phe

1 5 10 15

Glu Ser

<210> 3394

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3394

Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly Asp Ser Thr Phe

1 5 10 15

Glu Ser Lys Ser Tyr

20

<210> 3395

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3395

Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro Pro Ile Ser

1 5 10 15

Gly Gly Gly Tyr Arg Ala Arg Pro Ala

20 25

<210> 3396

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3396

Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly Asp Ser Thr Phe Glu

1 5 10 15

Ser Lys

<210> 3397

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3397

Thr Ser Ser Thr Ser Tyr Asn Arg Gly Asp Ser Thr Phe

1 5 10

<210> 3398

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3398

Gly Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val

1 5 10 15

<210> 3399

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3399

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly

1 5 10 15

<210> 3400

<211> 20

<212>PRT

<213> Bos taurus

<400> 3400

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys

1 5 10 15

Thr Arg Ser Ser

20

<210> 3401

<211> 3

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3401

Ala Ala Ala

1

<210> 3402

<211> 38

<212>PRT

<213> Mus musculus

<400> 3402

Lys Gly Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp

1 5 10 15

Leu Thr Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr

20 25 30

Thr Val Leu Ser Arg Ala

35

<210> 3403

<211> 16

<212>PRT

<213> Mus musculus

<400> 3403

Lys Leu Val Ile Ile Glu Ser Asp Leu Glu Arg Ala Glu Glu Arg Ala

1 5 10 15

<210> 3404

<211> 26

<212>PRT

<213> Mus musculus

<400> 3404

Lys Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser

1 5 10 15

Glu Glu Asp Lys Leu Thr Val Ser Arg Ala

20 25

<210> 3405

<211> 18

<212>PRT

<213> Mus musculus

<400> 3405

Arg Ile Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile

1 5 10 15

Lys Thr

<210> 3406

<211> 16

<212>PRT

<213> Mus musculus

<400> 3406

Arg Ser Ile Thr Thr Ile Ile Asp Thr Phe His Gln Tyr Ser Arg Lys

1 5 10 15

<210> 3407

<211> 32

<212>PRT

<213> Mus musculus

<400> 3407

Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly Val Thr His Asn

1 5 10 15

Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Met Arg Leu

20 25 30

<210> 3408

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3408

Gly Leu Glu Pro Gly Val Val Ala Glu Lys Val Arg Asn Leu Ser Val

1 5 10 15

<210> 3409

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3409

Ala Phe Arg Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg

1 5 10 15

Pro Gly

<210> 3410

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3410

Ala Gly Tyr Ala Leu Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu

1 5 10 15

<210> 3411

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3411

Ala Ile Ser Asp Tyr Val Phe Asn Thr Ala Ser Leu Val Tyr His Glu

1 5 10 15

Glu

<210> 3412

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3412

Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp

1 5 10 15

Thr

<210> 3413

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3413

Ala Leu Ala Thr Ile Ser Thr Leu Glu Ala Val Arg Gly Arg Pro Phe

1 5 10 15

<210> 3414

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3414

Ala Leu Thr Asn Gly Ile Tyr Pro His Lys Leu Val Phe

1 5 10

<210> 3415

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3415

Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu

1 5 10 15

Leu

<210> 3416

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3416

Ala Asn Gly Val Ile His Met Leu Asp Gly Ile Leu Leu Pro Pro Thr

1 5 10 15

<210> 3417

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3417

Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn

1 5 10 15

<210> 3418

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3418

Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala

1 5 10

<210> 3419

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3419

Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly

1 5 10 15

<210> 3420

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3420

Ala Pro Ser Ala Ile Leu Pro Leu Pro Gly Gln Ser Val Glu Arg

1 5 10 15

<210> 3421

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3421

Ala Pro Val Glu Leu Ile Leu Ser Asp Glu Thr Leu Pro Ala Pro Glu

1 5 10 15

<210> 3422

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3422

Ala Arg Thr Gln Leu Ser Trp Leu Lys Lys Gln Leu Ala Ala Ala

1 5 10 15

<210> 3423

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3423

Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met His Arg

1 5 10

<210> 3424

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3424

Ala Tyr Pro Arg Ile Ser Val Asn Asn Val Leu Pro Val Phe Asp Asn

1 5 10 15

<210> 3425

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3425

Asp Asp Asp Gly Thr Gly Gln Lys Gln Ile Trp Arg Ile Glu Gly Ser

1 5 10 15

Asn Lys Val Pro Val Asp Pro Ala

20

<210> 3426

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3426

Asp Asp Leu Lys Thr Asp Phe Tyr Lys Asp Leu Thr Ser Leu Gly His

1 5 10 15

Asn Glu Asn

<210> 3427

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3427

Asp Glu Pro Gln Tyr Leu Asp Leu Pro Ser Thr Ala Thr Ser Val Asn

1 5 10 15

<210> 3428

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3428

Asp Phe Asn Val Gly Gly Tyr Ile Gln Ala Val Leu Asp Arg

1 5 10

<210> 3429

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3429

Asp Gly Lys Arg Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn

1 5 10 15

<210> 3430

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3430

Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg Ala Ala Leu Gln

1 5 10 15

Ala

<210> 3431

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3431

Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu Phe

1 5 10 15

<210> 3432

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3432

Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr

1 5 10 15

<210> 3433

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3433

Asp Ile Arg Pro Glu Ile His Glu Asn Tyr Arg Ile Asn Gly

1 5 10

<210> 3434

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3434

Asp Lys Val Leu Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp

1 5 10 15

<210> 3435

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3435

Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu

1 5 10 15

His

<210> 3436

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3436

Glu Gly Ala Arg Asn Ile Val Ala Ala Met Lys Ala His Gly Val Asp

1 5 10 15

<210> 3437

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3437

Glu Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala

1 5 10

<210> 3438

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3438

Glu Asn Ile Pro Phe Thr Leu Pro Glu Val Ser Thr Asn Lys Thr

1 5 10 15

<210> 3439

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3439

Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala

1 5 10 15

Gly Leu Glu

<210> 3440

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3440

Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr

1 5 10 15

Thr Lys

<210> 3441

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3441

Glu Arg Asn Leu Val Ser Trp Glu Ser Gln Thr Gln Pro Gln

1 5 10

<210> 3442

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3442

Glu Arg Thr Ile Thr Met His Lys Asp Ser Thr Gly His Val Gly

1 5 10 15

<210> 3443

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3443

Glu Thr Phe Leu Lys Asp Leu Pro Ile Met Phe

1 5 10

<210> 3444

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3444

Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln

1 5 10

<210> 3445

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3445

Glu Val Glu Asn Ala Val Leu Gly Lys Asp Phe Lys

1 5 10

<210> 3446

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3446

Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly

1 5 10 15

Thr Glu Leu Val Asn Phe

20

<210> 3447

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3447

Phe Glu Pro Phe Phe Met Met Ile Ala Thr Pro Ala Pro His

1 5 10

<210> 3448

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3448

Phe Leu Glu Gln Gln Asn Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu

1 5 10 15

Lys Gly Gln Gly Lys

20

<210> 3449

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3449

Phe Leu Leu Phe Pro Asp Met Glu Ala

15

<210> 3450

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3450

Phe Pro Gly Phe Leu Glu Asn Gln Lys Asp Pro Leu Ala Val Asp Lys

1 5 10 15

<210> 3451

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3451

Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val

1 5 10 15

Ser

<210> 3452

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3452

Phe Arg Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro

1 5 10 15

Gly

<210> 3453

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3453

Phe Arg Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro

1 5 10 15

Gly

<210> 3454

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3454

Phe Ser Ile Ser Pro Asn Ala Val Ser Ala Glu Glu

1 5 10

<210> 3455

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3455

Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn

1 5 10

<210> 3456

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3456

Phe Val Glu Leu Gly Thr Gln Pro Ala Thr

1 5 10

<210> 3457

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3457

Gly Ala Tyr Tyr Leu Lys Leu Glu Asn Gln Ser Leu Lys Ser

1 5 10

<210> 3458

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3458

Gly Asp Ile Gln Gln Phe Leu Ile Thr Gly Asp Pro Lys Ala Ala Tyr

1 5 10 15

Asp

<210> 3459

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3459

Gly Glu Thr Ser Glu Met Tyr Leu Ile Gln Pro Asp Ser Ser Val Lys

1 5 10 15

Pro Tyr

<210> 3460

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3460

Gly Gly Gly Tyr Val Lys Leu Phe Pro Asn Ser Leu Asp Gln Thr

1 5 10 15

<210> 3461

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3461

Gly Gly His Ala Ile Arg Ile Leu Gly Trp Gly Val Glu Asn Gly Thr

1 5 10 15

Pro Tyr

<210> 3462

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3462

Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro

1 5 10 15

<210> 3463

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3463

Gly His Leu Ser Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val Val

1 5 10 15

Tyr

<210> 3464

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3464

Gly Ile Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr Lys Gly

1 5 10 15

<210> 3465

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3465

Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr Lys Gly

1 5 10 15

<210> 3466

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3466

Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser

1 5 10

<210> 3467

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3467

Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val Arg Ala Gly

1 5 10 15

<210> 3468

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3468

Gly Asn Arg Ile Ala Gln Trp Gln Ser Phe Gln Leu

1 5 10

<210> 3469

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3469

Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala Asn Leu

1 5 10 15

Ile Pro Pro Val Pro Asp

20

<210> 3470

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3470

Gly Pro Gly Ile Pro Gly Arg Phe Thr Lys Glu Ala Gly Thr Leu Ala

1 5 10 15

Tyr Tyr Glu

<210> 3471

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3471

Gly Pro Val Lys Val Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly

1 5 10 15

<210> 3472

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3472

Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly

1 5 10 15

<210> 3473

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3473

Gly Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr

1 5 10 15

Gly

<210> 3474

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3474

Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly

1 5 10 15

<210> 3475

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3475

Gly Thr Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val

1 5 10 15

Pro His

<210> 3476

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3476

Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala Val Thr Val Ser Gly

1 5 10 15

His Thr

<210> 3477

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3477

Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser Asn

1 5 10 15

Ala Gln Arg

<210> 3478

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3478

Gly Val Ile Lys Val Phe Asn Asp Met Lys Val Arg

1 5 10

<210> 3479

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3479

Gly Tyr Val Arg Asp Glu Thr Val Arg Ala Ala Pro Tyr

1 5 10

<210> 3480

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3480

His Leu Pro Asp Asn Ile Asn Val Tyr Ala Thr Thr Ala Ala Asn Pro

1 5 10 15

Arg Glu

<210> 3481

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3481

His Asn Gly Asn Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe

1 5 10 15

<210> 3482

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3482

Ile Gly Gly Val Ile Leu Phe His Glu Thr Leu Tyr Gln Lys Ala Asp

1 5 10 15

Asp

<210> 3483

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3483

Ile Lys Ile Ile Ser Lys Ile Glu Asn His Glu Gly Val Arg

1 5 10

<210> 3484

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3484

Ile Leu Glu Trp Ala Ala Glu Arg Gly Pro Ile Thr Ser Ala

1 5 10

<210> 3485

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3485

Ile Gln Ser Thr Tyr Asp Gln Asp His Thr Val Pro Ala Tyr Val Pro

1 5 10 15

Arg

<210> 3486

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3486

Ile Ser Thr Pro Glu Glu Leu Gly Leu Asp Lys Val

1 5 10

<210> 3487

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3487

Ile Val His Arg Tyr Met Thr Ile Thr Ser Glu Arg Ser Val Pro Ala

1 5 10 15

<210> 3488

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3488

Ile Tyr Val Phe His Thr Leu Gly Gln Tyr Phe

1 5 10

<210> 3489

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3489

Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu Met

1 5 10 15

<210> 3490

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3490

Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg

1 5 10 15

Asn Leu Gly Lys Val Gly Ser Lys

20

<210> 3491

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3491

Lys Pro Gln Tyr Met Val Leu Val Pro Ser Leu Leu His Thr

1 5 10

<210> 3492

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3492

Lys Thr Gly Lys Leu Val Ser Leu Ser Ala Gln Asn Leu Val Asp Cys

1 5 10 15

<210> 3493

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3493

Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His

1 5 10

<210> 3494

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3494

Leu Ala Val Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu

1 5 10

<210> 3495

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3495

Leu Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys

1 5 10 15

<210> 3496

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3496

Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala Ser Val Gly

1 5 10 15

<210> 3497

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3497

Leu Gly Glu Phe Val Ser Glu Thr Glu Ser Arg Gly

1 5 10

<210> 3498

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3498

Leu Gly Gln His Leu Leu Pro Trp Met Asp Arg Leu Ser Leu Glu

1 5 10 15

<210> 3499

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3499

Leu Ile Asn Glu Tyr Trp Val Leu Thr Ala Ala His Val Val Glu

1 5 10 15

<210> 3500

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3500

Leu Lys Gln Glu Tyr Phe Val Val Ala Ala Thr Leu Gln Asp Ile Ile

1 5 10 15

Arg

<210> 3501

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3501

Leu Lys Thr Gly Lys Leu Val Ser Leu Ser Ala Gln Asn Leu Val Asp

1 5 10 15

Cys

<210> 3502

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3502

Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln Asn Arg Ile

1 5 10 15

<210> 3503

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3503

Leu Asn Gln Glu Leu Arg Ala Asp Gly Thr Val Asn Gln Ile Glu Gly

1 5 10 15

<210> 3504

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3504

Leu Pro Gln Pro Asp Leu Arg Tyr Leu Phe Leu Asn Gly Asn Lys Leu

1 5 10 15

Ala Arg

<210> 3505

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3505

Leu Arg Val Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu

1 5 10 15

Pro

<210> 3506

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3506

Leu Ser Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met

1 5 10 15

<210> 3507

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3507

Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg

1 5 10

<210> 3508

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3508

Met Gln Gln Lys Leu Val Asp Gln Asn Ile Phe Ser Phe

1 5 10

<210> 3509

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3509

Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala

1 5 10

<210> 3510

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3510

Asn Asp Val Lys Asn Val Ile Ile Trp Gly Asn His Ser Ser Thr Gln

1 5 10 15

<210> 3511

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3511

Asn Glu Glu Glu Ile Arg Ala Asn Val Ala Val Val Ser Gly Ala Pro

1 5 10 15

<210> 3512

<211> 23

<212>PRT

<213> Homo sapiens

<400> 3512

Asn Leu Asp Phe Leu Lys Ala Val Asp Thr Asn Arg Ala Ser Val Gly

1 5 10 15

Gln Asp Ser Pro Glu Pro Arg

20

<210> 3513

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3513

Asn Pro Ala Glu Phe Val Val Asn Thr Ser Asn Ala Gly Ala Gly

1 5 10 15

<210> 3514

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3514

Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser

1 5 10 15

<210> 3515

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3515

Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys Gly Cys Ser His

1 5 10 15

Pro Ser

<210> 3516

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3516

Asn Pro Leu Glu Ile Val Ser Ile Pro Asp Asn His Gly His Ile Asp

1 5 10 15

Pro

<210> 3517

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3517

Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu

1 5 10 15

<210> 3518

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3518

Asn Val Pro Thr Ile Asp Ile His Met Asn Gln Ile Gly Phe Glu Arg

1 5 10 15

<210> 3519

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3519

Gln Gly Gly Thr Tyr Ser Lys Ala Ser Thr Pro Asn Gly Tyr Asp Asn

1 5 10 15

<210> 3520

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3520

Gln Pro Leu Gly Met Ile Ser Leu Met Lys Arg Pro Pro Gly Phe Ser

1 5 10 15

<210> 3521

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3521

Gln Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln Gly Ser Val Glu

1 5 10 15

<210> 3522

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3522

Gln Ser Leu Pro His Glu Asn Lys Pro Leu Thr Leu Ser Asn Tyr Gln

1 5 10 15

Thr Asn Lys Ala Lys His Asp Glu Leu

20 25

<210> 3523

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3523

Gln Thr Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala

1 5 10 15

Gly Ala Gly

<210> 3524

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3524

Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala

1 5 10

<210> 3525

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3525

Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg Gln Tyr Ser Gly

1 5 10 15

<210> 3526

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3526

Arg Pro Leu Leu Asp Lys Trp Pro Thr Thr Leu Ser Arg His Leu Gly

1 5 10 15

<210> 3527

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3527

Arg Pro Arg Ala Pro Ile Ile Ala Val Thr Arg Asn Pro Gln Thr Ala

1 5 10 15

<210> 3528

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3528

Ser Ala Arg Leu Thr Trp Asp Pro Thr Ser Arg Gln Ile Asn Gly

1 5 10 15

<210> 3529

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3529

Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu

1 5 10 15

<210> 3530

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3530

Ser Asp Val Asp Leu Ile Pro Met Asn Asp His Asn Ala Tyr Arg

1 5 10 15

<210> 3531

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3531

Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln Pro Gly

1 5 10

<210> 3532

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3532

Ser Gly Asp Val Phe Thr Ala Leu Ile Gly Glu Ile Ala Ser Pro Asn

1 5 10 15

<210> 3533

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3533

Ser Gly Lys Pro Gln Tyr Met Val Leu Val Pro Ser Leu Leu His Thr

1 5 10 15

Glu Thr

<210> 3534

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3534

Ser Gly Leu Glu Val Ile Asp Ala Met Arg Ser Gln Leu Gly Lys Ala

1 5 10 15

Thr Ala

<210> 3535

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3535

Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp

1 5 10 15

Thr

<210> 3536

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3536

Ser Leu Arg Pro Lys Asp Tyr Glu Val Asp Ala Thr Leu Lys Ser Leu

1 5 10 15

Asn Asn Gln

<210> 3537

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3537

Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly Asp

1 5 10 15

Gly

<210> 3538

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3538

Ser Pro Glu Arg Pro Phe Leu Ala Ile Leu Gly Gly Ala Lys Val Ala

1 5 10 15

Asp Lys

<210> 3539

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3539

Ser Pro Leu Ser Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala

1 5 10 15

Gln

<210> 3540

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3540

Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn Ile Leu Arg Leu

1 5 10

<210> 3541

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3541

Ser Pro Pro Ile Ser Tyr Ile Trp Tyr Lys Gln Gln Thr Asn Asn Gln

1 5 10 15

Glu Pro Ile

<210> 3542

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3542

Ser Pro Val Thr Gly Tyr Arg Val Thr Thr Thr Pro Lys Asn Gly Pro

1 5 10 15

Gly Pro Thr

<210> 3543

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3543

Ser Arg Leu Pro Ile Ile Asp Val Ala Pro Leu Asp Val Gly Ala Pro

1 5 10 15

Asp

<210> 3544

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3544

Ser Tyr Ala Gly Lys Tyr Val Pro Ala Ile Ala His Leu Ile His Ser

1 5 10 15

<210> 3545

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3545

Thr Ala Ala Asp Tyr Lys Ile Leu Gly Gly Ser Val Leu His Leu

1 5 10 15

<210> 3546

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3546

Thr Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr

1 5 10 15

Lys Ser Tyr Trp Lys

20

<210> 3547

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3547

Thr Gly Ala Gln Glu Leu Leu Arg Val Leu Arg Ala Gln Pro Val Gln

1 5 10 15

Val Ala

<210> 3548

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3548

Thr Gly Asp Ala Tyr Val Ile Leu Lys Thr Val Gln Leu Arg Asn Gly

1 5 10 15

Asn Leu

<210> 3549

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3549

Thr Gly Lys Leu Val Ser Leu Ser Ala Gln Asn Leu Val Asp

1 5 10

<210> 3550

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3550

Thr Gly Lys Leu Val Ser Leu Ser Ala Gln Asn Leu Val Asp Cys

1 5 10 15

<210> 3551

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3551

Thr Gly Asn Tyr Arg Ile Glu Ser Val Leu Ser Ser Ser Gly Lys

1 5 10 15

<210> 3552

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3552

Thr His Met Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser

1 5 10 15

<210> 3553

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3553

Thr Ile Tyr Val Ile Ala Leu Lys Asn Asn Gln Lys Ser Glu Pro Leu

1 5 10 15

<210> 3554

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3554

Thr Leu Asn Gln Ile Asp Glu Val Lys Val Trp Pro Gln Gln Pro Ser

1 5 10 15

<210> 3555

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3555

Thr Leu Gln Ser Phe Arg Gln Asp Val Asp Asn Ala Ser Leu Ala Arg

1 5 10 15

<210> 3556

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3556

Thr Ser Ala Thr Asn Ile Val Lys Trp Ile Thr Lys Gln Gln Asn Ala

1 5 10 15

Gln

<210> 3557

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3557

Thr Thr Ala Phe Gln Tyr Ile Ile Asp Asn Lys Gly Ile Asp Ser

1 5 10 15

<210> 3558

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3558

Val Ala Ile Gln Leu Asn Asp Thr His Pro Ser Leu Ala Ile Pro Glu

1 5 10 15

Leu Met Arg

<210> 3559

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3559

Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro

1 5 10 15

Arg Thr Glu Pro Arg

20

<210> 3560

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3560

Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser Arg Pro Gln Ala Pro

1 5 10 15

Ile Thr

<210> 3561

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3561

Val Asp Met Asp Phe Glu Val Glu Asn Ala Val Leu Gly Lys Asp Phe

1 5 10 15

Lys

<210> 3562

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3562

Val Phe Asn Ile Leu Arg Met Met Pro Lys Gly Ala Ala Leu His

1 5 10 15

<210> 3563

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3563

Val Gly Pro Val Asp Glu Val Arg Glu Leu Gln Lys Ala Ile Gly Ala

1 5 10 15

Val Pro Leu

<210> 3564

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3564

Val His Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu

1 5 10 15

<210> 3565

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3565

Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln Met Arg

1 5 10 15

<210> 3566

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3566

Val Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp

1 5 10 15

<210> 3567

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3567

Val Pro Val Pro Val Phe Cys Asp Met Thr Thr Glu Gly Gly Lys Trp

1 5 10 15

Thr

<210> 3568

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3568

Val Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu

1 5 10

<210> 3569

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3569

Val Ser Gly Thr Leu Val Leu Leu Gln Gly Ala Arg Gly Phe Ala

1 5 10 15

<210> 3570

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3570

Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu

1 5 10 15

<210> 3571

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3571

Val Ser Thr Ala Phe Val Tyr Thr Lys Asn Pro Asn Gly Tyr Ser

1 5 10 15

<210> 3572

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3572

Val Val Leu Pro Ser Tyr Glu Glu Ala Leu Ser Leu Pro Ser Lys Thr

1 5 10 15

Pro Glu Gly

<210> 3573

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3573

Val Val Tyr Tyr Arg Val Gln Asn Ala Thr Leu Ala Val Ala Asn

1 5 10 15

<210> 3574

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3574

Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp

1 5 10 15

Thr Ala

<210> 3575

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3575

Tyr Asp Gly Ser His Arg Tyr Val Ile Leu Lys Ser Glu Pro Val His

1 5 10 15

Pro Phe Gly

<210> 3576

<211> 26

<212>PRT

<213> Homo sapiens

<400> 3576

Tyr Asp Leu Arg His Thr Phe Met Gly Val Val Ser Leu Gly Ser Pro

1 5 10 15

Ser Gly Glu Val Ser His Pro Arg Lys Thr

20 25

<210> 3577

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3577

Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr

1 5 10

<210> 3578

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3578

Tyr Leu Gln Met Asn Ser Val Arg Ala Glu Asp Thr

1 5 10

<210> 3579

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3579

Tyr Val Asn Gly Leu Thr Leu Gly Gly Gln Lys

1 5 10

<210> 3580

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3580

Cys Asp Met Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn

1 5 10 15

<210> 3581

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3581

Asp Val Ser Ala Gln Met Glu Tyr Cys Arg Thr Pro Cys Thr Val

1 5 10 15

<210> 3582

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3582

Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys Pro

1 5 10 15

<210> 3583

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3583

Glu Ala Val Gln Ser Thr Ser Ser Ser Ser Gln Phe Tyr Met Tyr

1 5 10 15

<210> 3584

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3584

Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr

1 5 10 15

<210> 3585

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3585

Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys Val Thr Ser Gly

1 5 10 15

<210> 3586

<211> 12

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3586

Gly Leu Glu Pro Gly Val Val Ala Glu Lys Val Arg

1 5 10

<210> 3587

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3587

Gly Ser Ser Glu Arg Gly Ser Ala Gly His Trp Thr Ser Glu Ser

1 5 10 15

<210> 3588

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3588

Ile Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys Ile

1 5 10 15

<210> 3589

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3589

Ile Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly

1 5 10 15

<210> 3590

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3590

Leu Glu Asn Leu Arg Ser Lys Ile Gln Lys Leu Glu Ser Asp Val

1 5 10 15

<210> 3591

<211> 11

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3591

Leu Glu Pro Gly Val Val Ala Glu Lys Val Arg

1 5 10

<210> 3592

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3592

Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp Glu Leu

1 5 10 15

<210> 3593

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3593

Leu Met Gly Glu Asn Arg Thr Met Thr Ile His Asn Gly Met Phe

1 5 10 15

<210> 3594

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3594

Asn Ser Asn Ile Pro Thr Asn Leu Arg Val Leu Arg Ser Ile Leu

1 5 10 15

<210> 3595

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3595

Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp Trp Tyr

1 5 10 15

<210> 3596

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3596

Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg

1 5 10 15

<210> 3597

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3597

Gln Lys Gln Leu Glu Gln Val Ile Ala Lys Asp Leu Leu Pro Ser

1 5 10 15

<210> 3598

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3598

Gln Met Glu Tyr Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile

1 5 10 15

<210> 3599

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3599

Gln Asn Pro Gly Ser Pro Arg Pro Gly Ser Thr Gly Thr Trp Asn

1 5 10 15

<210> 3600

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3600

Ser Glu Thr Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn

1 5 10 15

<210> 3601

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3601

Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp

1 5 10 15

<210> 3602

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3602

Ser Gly Pro Gly Ser Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly

1 5 10 15

<210> 3603

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3603

Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys

1 5 10 15

<210> 3604

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3604

Thr Thr Arg Arg Ser Cys Ser Lys Thr Val Thr Lys Thr Val Ile

1 5 10 15

<210> 3605

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3605

Thr Val Gln Asn Glu Ala Asn Lys Tyr Gln Ile Ser Val Asn Lys

1 5 10 15

<210> 3606

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3606

Val Asp Ile Asp Ile Lys Ile Arg Ser Cys Arg Gly Ser Cys Ser

1 5 10 15

<210> 3607

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3607

Val Asp Ile Asp Ile Lys Ile Arg Ser Cys Arg Gly Ser Cys Ser

1 5 10 15

<210> 3608

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3608

Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys Leu Val

1 5 10 15

<210> 3609

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3609

Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys

1 5 10 15

<210> 3610

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3610

Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr

1 5 10 15

<210> 3611

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3611

Trp Tyr Ser Met Arg Lys Met Ser Met Lys Ile Arg Pro Phe Phe

1 5 10 15

<210> 3612

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3612

Tyr Cys Gly Leu Pro Gly Glu Tyr Trp Leu Gly Asn Asp Lys Ile

1 5 10 15

<210> 3613

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3613

Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys

1 5 10 15

Lys

<210> 3614

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3614

Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys Asp Ser

1 5 10 15

<210> 3615

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3615

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 3616

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3616

Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val

1 5 10 15

<210> 3617

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3617

Gly Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val

1 5 10 15

Pro Gly Val Arg

20

<210> 3618

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3618

Gly Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val

1 5 10 15

Pro Gly Val Arg

20

<210> 3619

<211> 5

<212>PRT

<213> Homo sapiens

<400> 3619

Gly Tyr Arg Ala Arg

15

<210> 3620

<211> 4

<212>PRT

<213> Homo sapiens

<400> 3620

Arg Val Val Glu

1

<210> 3621

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3621

Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg His Pro Asp

1 5 10 15

<210> 3622

<211> 5

<212>PRT

<213> Homo sapiens

<400> 3622

Val Glu Arg His Gln

15

<210> 3623

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3623

Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn

1 5 10 15

Ile Leu Val Phe

20

<210> 3624

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3624

Ala Gly Thr Ile Ala Gly Leu Asn Val Met Arg Ile Ile Asn Glu Pro

1 5 10 15

Thr Ala Ala Ala

20

<210> 3625

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3625

Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg Ser Thr Met Lys

1 5 10 15

Pro Val Gln Lys

20

<210> 3626

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3626

Ala Lys Arg Ala Leu Ser Ser Gln His Gln Ala Arg Ile Glu Ile Glu

1 5 10 15

Ser Phe Tyr Glu

20

<210> 3627

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3627

Ala Lys Arg Ala Leu Ser Ser Gln His Gln Ala Arg Ile Glu Ile Glu

1 5 10 15

Ser Phe Tyr Glu

20

<210> 3628

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3628

Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu Asp Phe Asp Gln Arg

1 5 10 15

Val Met Glu His

20

<210> 3629

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3629

Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly Ile Asp Leu Gly

1 5 10 15

Thr Thr Tyr Ser

20

<210> 3630

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3630

Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp Thr Arg Asn Glu Leu Glu

1 5 10 15

Ser Tyr Ala Tyr Ser

20

<210> 3631

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3631

Glu Ser His Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys

1 5 10 15

Glu Leu Glu Glu

20

<210> 3632

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3632

Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp Thr Arg Asn

1 5 10 15

Glu Leu Glu Ser

20

<210> 3633

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3633

Gly Ser Ala Gly Pro Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Leu

1 5 10 15

His His His

20

<210> 3634

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3634

Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile Pro Lys Ile

1 5 10 15

Gln Gln Leu Val

20

<210> 3635

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3635

Lys Asp Asn Arg Ala Val Gln Lys Leu Arg Arg Glu Val Glu Lys Ala

1 5 10 15

Lys Arg Ala Leu

20

<210> 3636

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3636

Lys Glu Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu

1 5 10 15

Ser His Gln Asp

20

<210> 3637

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3637

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

<210> 3638

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3638

Lys Leu Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln

1 5 10 15

His Gln Ala Arg

20

<210> 3639

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3639

Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu

1 5 10 15

Arg Arg Glu Val

20

<210> 3640

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3640

Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu

1 5 10 15

Arg Arg Glu Val

20

<210> 3641

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3641

Leu Tyr Lys Lys Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala

1 5 10 15

Val Gln Lys Leu

20

<210> 3642

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3642

Asn Lys Ile Thr Ile Thr Asn Asp Gln Asn Arg Leu Thr Pro Glu Glu

1 5 10 15

Ile Glu Arg Met

20

<210> 3643

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3643

Asn Pro Glu Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Thr

1 5 10 15

Trp Asn Asp Pro

20

<210> 3644

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3644

Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp Ala

1 5 10 15

Glu Lys Phe Ala

20

<210> 3645

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3645

Arg Lys Asp Asn Arg Ala Val Gln Lys Leu Arg Arg Glu Val Glu Lys

1 5 10 15

Ala Lys Arg Ala

20

<210> 3646

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3646

Arg Lys Asp Asn Arg Ala Val Gln Lys Leu Arg Arg Glu Val Glu Lys

1 5 10 15

Ala Lys Arg Ala

20

<210> 3647

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3647

Ser Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala

1 5 10 15

Ala Lys Asn Gln

20

<210> 3648

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3648

Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr Ala Glu Asp

1 5 10 15

Lys Gly Thr Gly

20

<210> 3649

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3649

Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr Ala Glu Asp

1 5 10 15

Lys Gly Thr Gly

20

<210> 3650

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3650

Thr Val Gly Gly Val Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val

1 5 10 15

Pro Thr Lys Lys

20

<210> 3651

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3651

Thr Val Pro Ala Tyr Phe Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp

1 5 10 15

Ala Gly Thr Ile

20

<210> 3652

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3652

Thr Val Thr Ile Lys Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp

1 5 10 15

Asn His Leu Leu

20

<210> 3653

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3653

Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser Tyr

1 5 10 15

Val Ala Phe Thr

20

<210> 3654

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3654

Val Lys Glu Phe Phe Asn Gly Lys Glu Pro Ser Arg Gly Ile Asn Pro

1 5 10 15

Asp Glu Ala Val

20

<210> 3655

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3655

Tyr Glu Gly Glu Asp Phe Ser Glu Thr Leu Thr Arg Ala Lys Phe Glu

1 5 10 15

Glu Leu Asn Met

20

<210> 3656

<211> 327

<212>PRT

<213> Homo sapiens

<400> 3656

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg

1 5 10 15

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr

20 25 30

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser

35 40 45

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser

50 55 60

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr

65 70 75 80

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys

85 90 95

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro

100 105 110

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

115 120 125

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

130 135 140

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp

145 150 155 160

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe

165 170 175

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

180 185 190

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu

195 200 205

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

210 215 220

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys

225 230 235 240

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp

245 250 255

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

260 265 270

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser

275 280 285

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser

290 295 300

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser

305 310 315 320

Leu Ser Leu Ser Leu Gly Lys

325

<210> 3657

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 3657

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Thr

1 5 10 15

<210> 3658

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 3658

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Thr

1 5 10 15

<210> 3659

<211> 15

<212>PRT

<213> Rattus norvegicus

<400> 3659

Gly Ile Ala Gly Phe Lys Gly Glu Gln Gly Pro Lys Gly Glu Thr

1 5 10 15

<210> 3660

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3660

Gly Ile Ala Gly Asn Lys Gly Asp Gln Gly Pro Lys Gly Glu Asx

1 5 10 15

<210> 3661

<211> 20

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3661

Thr Leu Val Val Asn Lys Ile Arg Gly Thr Phe Lys Ser Val Ala Val

1 5 10 15

Lys Ala Pro Gly

20

<210> 3662

<211> 20

<212>PRT

<213> Chlamydia pneumoniae

<400> 3662

Thr Leu Val Val Asn Lys Leu Gln Gly Leu Leu Gln Val Thr Val Val

1 5 10 15

Thr Ile Pro Gln

20

<210> 3663

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3663

Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg Gln Tyr

1 5 10

<210> 3664

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3664

Leu Thr Val Gly Leu Thr Arg Arg Gly Gln Pro Arg Gln Tyr

1 5 10

<210> 3665

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3665

Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn

1 5 10

<210> 3666

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3666

Ala Pro Ala Pro Thr Ala Arg Asn Lys Leu Thr Ser Glu

1 5 10

<210> 3667

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3667

Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg His

1 5 10 15

Gln Gly Val Met Val

20

<210> 3668

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3668

Glu Ala Gln Ser Lys Arg Gly Ile Leu Thr Leu Lys

1 5 10

<210> 3669

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3669

Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg

1 5 10

<210> 3670

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3670

Gly Pro Ser Ile Val His Arg Lys Cys Phe

1 5 10

<210> 3671

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3671

Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val Ala Pro Glu Glu

1 5 10 15

<210> 3672

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3672

Lys Leu Thr Ser Glu Ala Arg Gly Arg Ile Pro Val Ala Gln Lys

1 5 10 15

<210> 3673

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3673

Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu

1 5 10 15

Ser Ala Ile Arg

20

<210> 3674

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3674

Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys

1 5 10

<210> 3675

<211> 27

<212>PRT

<213> Homo sapiens

<400> 3675

Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu

1 5 10 15

Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu

20 25

<210> 3676

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3676

Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile

1 5 10

<210> 3677

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3677

Arg Gln Val Asp Ala Arg Arg Asn Val Pro Gln Asn Asp

1 5 10

<210> 3678

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3678

Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg

1 5 10

<210> 3679

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3679

Ser Ala Val Arg Ala Arg Ser Ser Val Pro Gly Val Arg

1 5 10

<210> 3680

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3680

Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu Leu Gln

1 5 10 15

Ala Ala Gly

<210> 3681

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3681

Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe

1 5 10 15

Gln Gln Gly

<210> 3682

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3682

Ala Ser Thr Asn Gly Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala

1 5 10 15

Arg Val Gln

<210> 3683

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3683

Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala Arg Glu Arg Met Phe

1 5 10 15

Asn Gly Glu

<210> 3684

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3684

Glu Asp Leu Glu Arg Leu Leu Pro His Lys Val Phe Glu Gly Asn Arg

1 5 10 15

Pro Thr Asn

<210> 3685

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3685

Phe Glu Phe Trp Asp Trp Val Gly Gly Arg Tyr Ser Leu Trp Ser Ala

1 5 10 15

Ile Gly Leu

<210> 3686

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3686

Lys Leu Gln Gln Trp Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg

1 5 10 15

Arg Leu Phe

<210> 3687

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3687

Asn Tyr Thr Glu Gly Arg Ala Val Leu His Val Ala Leu Arg Asn Arg

1 5 10 15

Ser Asn Thr

<210> 3688

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3688

Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr Thr Gly

1 5 10 15

Lys Thr Ile

<210> 3689

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3689

Val Tyr Ala Thr Arg Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro

1 5 10 15

<210> 3690

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3690

Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys

1 5 10 15

Lys

<210> 3691

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3691

Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly Arg

1 5 10 15

Ser Gly Ser

<210> 3692

<211> 5

<212>PRT

<213> Homo sapiens

<400> 3692

Thr Arg Gly Arg Ser

15

<210> 3693

<211> 36

<212>PRT

<213> Unknown

<220>

<223> epitope associated with rheumatoid arthritis

<400> 3693

His Ser Thr Lys Arg Gly His Ala Lys Ser Arg Pro Val Arg Gly His

1 5 10 15

Gln Ser His Gln Glu Ser Thr Arg Gly Arg Ser Arg Gly Arg Ser Gly

20 25 30

Arg Ser Gly Ser

35

<210> 3694

<211> 15

<212>PRT

<213> Trypanosoma cruzi

<400> 3694

Ala Glu Glu Glu Glu Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10 15

<210> 3695

<211> 32

<212>PRT

<213> Trypanosoma cruzi

<400> 3695

Ala Ser Ala Pro Thr Ala Ala Ala Ala Ala Ser Gly Gly Ala Ala Ala

1 5 10 15

Pro Ala Ala Ala Ala Glu Glu Glu Glu Asp Asp Asp Met Gly Phe Gly

20 25 30

<210> 3696

<211> 35

<212>PRT

<213> Trypanosoma cruzi

<400> 3696

Ala Ser Ala Pro Thr Ala Ala Ala Ala Ala Ser Gly Gly Ala Ala Ala

1 5 10 15

Pro Ala Ala Ala Ala Glu Glu Glu Glu Asp Asp Asp Met Gly Phe Gly

20 25 30

Leu Phe Asp

35

<210> 3697

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3697

Cys Ala Pro Glu Ser Ile Glu Phe Pro Val Ser Glu Ala Arg Val Leu

1 5 10 15

Glu Asp

<210> 3698

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3698

Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10

<210> 3699

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 3699

Asp Leu Ser Leu Leu Gly Lys Ala Arg Lys Val Val Val Thr Lys Asp

1 5 10 15

<210> 3700

<211> 13

<212>PRT

<213> Trypanosoma cruzi

<400> 3700

Glu Glu Glu Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10

<210> 3701

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3701

Glu Glu Ser Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10

<210> 3702

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3702

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr

1 5 10 15

Pro

<210> 3703

<211> 5

<212>PRT

<213> Homo sapiens

<400> 3703

Glu Arg Lys Arg Arg

15

<210> 3704

<211> 12

<212>PRT

<213> Mus musculus

<400> 3704

Phe Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu

1 5 10

<210> 3705

<211> 15

<212>PRT

<213> Human herpes virus

<400> 3705

Gly Asp Asp Gly Asp Asp Gly Asp Glu Gly Gly Asp Gly Asp Glu

1 5 10 15

<210> 3706

<211> 24

<212>PRT

<213> Human herpes virus

<400> 3706

Gly Gly Asp Asn His Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Gly Gly Arg Pro Gly Ala Pro Gly

20

<210> 3707

<211> 9

<212>PRT

<213> Human herpes virus

<400> 3707

Gly Leu Cys Thr Leu Val Ala Met Leu

15

<210> 3708

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3708

Gly Pro Ser Gln Gln Val Met Thr Pro Gln Gly Arg Gly Thr Val Ala

1 5 10 15

Ala Ala

<210> 3709

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3709

His Leu Lys Ala Val Lys Met Thr Leu Lys

1 5 10

<210> 3710

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3710

Ile Leu Gln Asp Gly Arg Ile Phe Ile

15

<210> 3711

<211> 22

<212>PRT

<213> Artemia franciscana

<400> 3711

Lys Lys Glu Glu Lys Lys Glu Glu Ser Glu Glu Glu Asp Glu Asp Met

1 5 10 15

Gly Phe Gly Leu Phe Asp

20

<210> 3712

<211> 24

<212>PRT

<213> Mus musculus

<400> 3712

Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys

1 5 10 15

Pro Ala Ile Arg Arg Leu Ala Arg

20

<210> 3713

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3713

Lys Arg Val Leu Gly Leu Val Leu Leu Arg Gly Glu Asn Leu Val Ser

1 5 10 15

Met

<210> 3714

<211> 7

<212>PRT

<213> Trypanosoma cruzi

<400> 3714

Met Gly Phe Gly Leu Phe Asp

15

<210> 3715

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3715

Pro Thr Arg Ala Glu Thr Arg Glu Glu Arg Met Glu Arg Lys Arg Arg

1 5 10 15

Glu Lys Ile Glu

20

<210> 3716

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3716

Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys Asp

1 5 10 15

<210> 3717

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3717

Ser Ile Arg Gly Asn Asn Ile Arg Tyr

15

<210> 3718

<211> 24

<212>PRT

<213> Mus musculus

<400> 3718

Thr Tyr Thr Glu His Ala Lys Arg Lys Thr Val Thr Ala Met Asp Val

1 5 10 15

Val Tyr Ala Leu Lys Arg Gln Gly

20

<210> 3719

<211> 13

<212>PRT

<213> Human herpes virus

<400> 3719

Arg Gly Gln Gly Asp Gly Gly Arg Arg Lys Lys Gly Gly

1 5 10

<210> 3720

<211> 21

<212>PRT

<213> Mus musculus

<400> 3720

Ala Ala Met Ala Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu

1 5 10 15

Pro Lys Arg Ala Val

20

<210> 3721

<211> 22

<212>PRT

<213> Mus musculus

<400> 3721

Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu Met Gln Glu Val Gln

1 5 10 15

Ser Ser Arg Ser Gly Arg

20

<210> 3722

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3722

Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp Tyr Arg Gln Thr

1 5 10 15

<210> 3723

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3723

Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly

1 5 10 15

<210> 3724

<211> 21

<212>PRT

<213> Mus musculus

<400> 3724

Asp Lys Ile Val Leu Gln Lys Tyr His Thr Ile Asn Gly His Asn Ala

1 5 10 15

Glu Val Arg Lys Ala

20

<210> 3725

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3725

Asp Pro Ile Ser Gly His Val Ser Leu Phe

1 5 10

<210> 3726

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3726

Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala

1 5 10 15

<210> 3727

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3727

Lys Pro Ile Ser Gly His Asn Ser Leu Phe

1 5 10

<210> 3728

<211> 21

<212>PRT

<213> Mus musculus

<400> 3728

Leu Thr Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg

1 5 10 15

Gly Phe Gly Phe Val

20

<210> 3729

<211> 21

<212>PRT

<213> Mus musculus

<400> 3729

Met Glu Arg Glu Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu

1 5 10 15

Ser Phe Glu Thr Thr

20

<210> 3730

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3730

Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu

1 5 10 15

<210> 3731

<211> 21

<212>PRT

<213> Mus musculus

<400> 3731

Arg Gly Phe Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala

1 5 10 15

Ala Met Ala Ala Arg

20

<210> 3732

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3732

Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe

1 5 10

<210> 3733

<211> 27

<212>PRT

<213> Mus musculus

<400> 3733

Ser Gly Lys Pro Gly Ala His Val Thr Val Lys Lys Leu Phe Val Gly

1 5 10 15

Gly Ile Lys Glu Asp Thr Glu Glu His His Leu

20 25

<210> 3734

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3734

Ser Pro Arg Ser Gly Asp Leu Ser Val Tyr

1 5 10

<210> 3735

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3735

Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser

1 5 10 15

Arg Ser Gly Ser Pro Met Ala Arg Arg

20 25

<210> 3736

<211> 19

<212>PRT

<213> Mus musculus

<400> 3736

Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Lys Pro Gly Phe Gly

1 5 10 15

Tyr Gly Gly

<210> 3737

<211> 21

<212>PRT

<213> Mus musculus

<400> 3737

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu

1 5 10 15

Tyr Arg Asn Gly Lys

20

<210> 3738

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3738

Lys Glu Gln Phe Leu Asp Gly Asp Gly Trp Thr Ser Arg Trp Ile Glu

1 5 10 15

Ser Lys

<210> 3739

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3739

Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr

1 5 10 15

Ala Phe Ile Glu Tyr

20

<210> 3740

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3740

Tyr Thr Cys Pro Leu Cys Arg Ala Pro Val

1 5 10

<210> 3741

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3741

Asp Trp Glu Tyr Ser Val Trp Leu Ser Asn

1 5 10

<210> 3742

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3742

Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Glu Glu

1 5 10 15

Trp Ile Gly

<210> 3743

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3743

Lys Gly Glu Gln Gly Glu Pro Gly Ala

15

<210> 3744

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3744

Val Thr Trp Glu Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys

1 5 10 15

Lys Ile

<210> 3745

<211> 26

<212>PRT

<213> Homo sapiens

<400> 3745

Ala Gly Ala Ala Arg Asp Ala Leu Gln Gly Phe Lys Ile Thr Gln Asn

1 5 10 15

Asn Ala Met Lys Ile Ser Phe Ala Lys Lys

20 25

<210> 3746

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3746

Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu

1 5 10 15

Val Leu Glu Gly

20

<210> 3747

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3747

Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg Leu His Arg Phe

1 5 10 15

Leu Cys Phe Gly Ser

20

<210> 3748

<211> 15

<212>PRT

<213> Bos taurus

<400> 3748

Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr Leu Tyr Gly

1 5 10 15

<210> 3749

<211> 18

<212>PRT

<213> Bos taurus

<400> 3749

Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg Thr Leu Tyr Gly Phe

1 5 10 15

Gly Gly

<210> 3750

<211> 13

<212>PRT

<213> Artemia franciscana

<400> 3750

Glu Glu Glu Asp Glu Asp Met Gly Phe Gly Leu Phe Asp

1 5 10

<210> 3751

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3751

Glu Leu Tyr Lys Glu Lys Ala Leu Ser Val Glu Thr Glu Lys Leu Leu

1 5 10 15

Lys Tyr Leu Glu Ala Val

20

<210> 3752

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3752

Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly Trp

1 5 10 15

Thr Ser Arg Trp Ile Glu Ser Lys

20

<210> 3753

<211> 15

<212>PRT

<213> Bos taurus

<400> 3753

Gly Ile Thr Lys Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly

1 5 10 15

<210> 3754

<211> 23

<212>PRT

<213> Homo sapiens

<400> 3754

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Gly Pro Arg Arg

20

<210> 3755

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3755

Gly Ser Gly Lys Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe

1 5 10 15

<210> 3756

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3756

Lys Ala Leu Ser Val Glu Thr Glu Lys Leu Leu Lys Tyr Leu Glu Ala

1 5 10 15

Val

<210> 3757

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3757

Lys Leu Ile Val Cys Gly Met Thr Ser Asn Gly Phe Thr Ile Ala Asp

1 5 10 15

Pro Asp Asp Arg Gly Met Leu Asp

20

<210> 3758

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3758

Lys Met Thr Leu Lys Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser

1 5 10 15

Ile Arg Gly Asn Arg Ile Arg Tyr

20

<210> 3759

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3759

Lys Pro Lys Ala Ala Lys Pro Lys Lys Ala Ala Ala Lys Lys Lys

1 5 10 15

<210> 3760

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3760

Met Ala Val Pro Glu Thr Arg Pro Asn His Thr

1 5 10

<210> 3761

<211> 23

<212>PRT

<213> Homo sapiens

<400> 3761

Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile

1 5 10 15

Ala Asn Ser Gln Asp Gly Tyr

20

<210> 3762

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3762

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr

1 5 10 15

Ile Glu Leu Lys

20

<210> 3763

<211> 17

<212>PRT

<213> Enterovirus A

<400> 3763

Met Val Thr Ser Thr Ile Thr Glu Lys Leu Leu Lys Asn Leu Val Lys

1 5 10 15

Ile

<210> 3764

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3764

Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10

<210> 3765

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3765

Pro Pro Gly Met Arg Pro Pro

15

<210> 3766

<211> 21

<212>PRT

<213> Mus musculus

<400> 3766

Pro Thr Arg Ala Glu Thr Arg Glu Glu Arg Met Glu Arg Lys Arg Arg

1 5 10 15

Glu Lys Ile Glu Arg

20

<210> 3767

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3767

Pro Thr Arg Ala Pro Ser Gly Pro Arg Pro Pro

1 5 10

<210> 3768

<211> 21

<212>PRT

<213> Mus musculus

<400> 3768

Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr

1 5 10 15

Ala Phe Ile Glu Tyr

20

<210> 3769

<211> 21

<212>PRT

<213> Mus musculus

<400> 3769

Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr

1 5 10 15

Ala Phe Ile Glu Tyr

20

<210> 3770

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3770

Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln

1 5 10 15

Lys Arg Gly Arg

20

<210> 3771

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3771

Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Gln

1 5 10 15

Arg Arg Ala Ala

20

<210> 3772

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3772

Arg Arg Arg Glu Gly Pro Asp Arg Ser Pro Arg

1 5 10

<210> 3773

<211> 29

<212>PRT

<213> Bos taurus

<400> 3773

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys

1 5 10 15

Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile

20 25

<210> 3774

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3774

Ser Gln Phe Gly Gln Ile Leu Asp Ile Leu Val Ser Arg Ser Leu Lys

1 5 10 15

Met Arg Gly Gln Ala Phe Val Ile

20

<210> 3775

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3775

Thr Gly Ala Leu Asp Val Ile Arg Asn Phe Thr Leu Asp Met Ile

1 5 10 15

<210> 3776

<211> 18

<212>PRT

<213> Bos taurus

<400> 3776

Thr Lys Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg

1 5 10 15

Ile Ser

<210> 3777

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3777

Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10 15

Leu Ser His Leu Lys Pro

20

<210> 3778

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3778

Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser

1 5 10 15

Ile Glu Ser Ala

20

<210> 3779

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3779

Val Cys Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile

1 5 10 15

His Pro Phe His Ile

20

<210> 3780

<211> 37

<212>PRT

<213> Homo sapiens

<400> 3780

Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

20 25 30

Gly Gly Pro Arg Arg

35

<210> 3781

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3781

Val Ser Lys Asp Asp Ser Ile Ile Ser Ser Leu Asp Val Thr Asp

1 5 10 15

<210> 3782

<211> 20

<212>PRT

<213> Mus musculus

<400> 3782

Tyr Asp Glu Arg Pro Gly Pro Ser Pro Leu Pro His Arg Asp Arg Asp

1 5 10 15

Arg Asp Arg Glu

20

<210> 3783

<211> 21

<212>PRT

<213> Mus musculus

<400> 3783

Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys His His Asn Gln

1 5 10 15

Pro Tyr Cys Gly Ile

20

<210> 3784

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3784

Ala Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe

1 5 10 15

<210> 3785

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3785

Ala Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe

1 5 10 15

<210> 3786

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3786

Ala Ile Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala

1 5 10 15

<210> 3787

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3787

Ala Ile Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu Val His Glu

1 5 10 15

Leu Tyr Lys Glu

20

<210> 3788

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3788

Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu

1 5 10 15

Val Leu Glu Gly

20

<210> 3789

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3789

Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln

1 5 10 15

<210> 3790

<211> 3

<212>PRT

<213> Homo sapiens

<400> 3790

Cys Val Pro

1

<210> 3791

<211> 6

<212>PRT

<213> Homo sapiens

<400> 3791

Asp Gly Gln Phe Cys His

15

<210> 3792

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3792

Asp Leu Leu Arg Leu Ser His Leu Lys Pro Ser Ser Glu Gly Leu Ala

1 5 10 15

Ile Val Thr Lys

20

<210> 3793

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3793

Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala

1 5 10 15

<210> 3794

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3794

Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala

1 5 10 15

<210> 3795

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3795

Glu Ala Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

<210> 3796

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3796

Glu Lys Ala Leu Ser Val Glu Thr Glu Lys Leu Leu Lys Tyr Leu Glu

1 5 10 15

Ala Val

<210> 3797

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3797

Glu Arg Asp Arg Lys Arg Glu Lys Arg Lys Pro Lys Ser

1 5 10

<210> 3798

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3798

Gly Gln Ile Pro Pro Gly Ala Met

15

<210> 3799

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3799

Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys Arg

1 5 10 15

<210> 3800

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3800

Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Pro Arg Arg

1 5 10

<210> 3801

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3801

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Pro Arg Arg

1 5 10 15

<210> 3802

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3802

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Pro Arg Arg

1 5 10 15

<210> 3803

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3803

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10

<210> 3804

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3804

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Pro

1 5 10 15

<210> 3805

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3805

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

<210> 3806

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3806

Gly Arg Gly Thr Val Ala Ala Ala Ala Ala Ala Ala Thr

1 5 10

<210> 3807

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3807

Gly Ser Gly Lys Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe

1 5 10 15

<210> 3808

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3808

His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg

1 5 10

<210> 3809

<211> 27

<212>PRT

<213> Homo sapiens

<400> 3809

Ile Pro Pro Gly Arg Gly Thr Pro Met Gly Met Pro Pro Pro Gly Met

1 5 10 15

Arg Pro Pro Pro Pro Gly Met Arg Gly Leu Leu

20 25

<210> 3810

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3810

Lys Ala Leu Ser Val Glu Thr Glu Lys Leu Leu Lys Tyr Leu Glu Ala

1 5 10 15

Val Glu Lys Val

20

<210> 3811

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3811

Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp Leu

1 5 10

<210> 3812

<211> 12

<212>PRT

<213> Mus musculus

<400> 3812

Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys

1 5 10

<210> 3813

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3813

Lys Arg Glu Ala Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

<210> 3814

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3814

Lys Arg Thr Lys Asp Glu Leu Glu Val Ile His Leu Ile Glu Glu His

1 5 10 15

Arg Leu Val Arg

20

<210> 3815

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3815

Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg

1 5 10

<210> 3816

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3816

Leu Asp Gly Pro Thr Tyr Lys Arg Arg Leu Asp Glu Cys Glu Glu

1 5 10 15

<210> 3817

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3817

Leu Lys Ala Val Lys Met Thr Leu Lys Asn Arg Glu Pro

1 5 10

<210> 3818

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3818

Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu Asp Glu Glu Gly Ser

1 5 10 15

<210> 3819

<211> 39

<212>PRT

<213> Homo sapiens

<400> 3819

Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu

1 5 10 15

Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser

20 25 30

Ser Gly Val Asn Leu Gln Ser

35

<210> 3820

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3820

Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys Asn

1 5 10

<210> 3821

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3821

Asn Trp His Gln Leu His Gly Lys Lys Glu Ala Tyr

1 5 10

<210> 3822

<211> 13

<212>PRT

<213> Bos taurus

<400> 3822

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly

1 5 10

<210> 3823

<211> 25

<212>PRT

<213> Bos taurus

<400> 3823

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val Thr Lys Ala Gln Lys Lys Asp

20 25

<210> 3824

<211> 7

<212>PRT

<213> Simian virus 40

<400> 3824

Pro Lys Lys Lys Arg Lys Val

15

<210> 3825

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3825

Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly

1 5 10 15

<210> 3826

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3826

Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly

1 5 10 15

<210> 3827

<211> 35

<212>PRT

<213> Homo sapiens

<400> 3827

Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly

20 25 30

Pro Arg Arg

35

<210> 3828

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3828

Gln Gly Phe Pro Phe Tyr Asp Lys Pro Met Arg Ile

1 5 10

<210> 3829

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3829

Gln Val Ala Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn

1 5 10 15

<210> 3830

<211> 6

<212>PRT

<213> Homo sapiens

<400> 3830

Gln Val Lys Gly Phe Val

15

<210> 3831

<211> 40

<212>PRT

<213> Homo sapiens

<400> 3831

Gln Tyr Pro Pro Gly Arg Gly Gly Pro Pro Pro Pro Met Gly Arg Gly

1 5 10 15

Ala Pro Pro Pro Gly Met Met Gly Pro Pro Pro Gly Met Arg Pro Pro

20 25 30

Met Gly Pro Pro Met Gly Ile Pro

35 40

<210> 3832

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3832

Arg Cys Arg Leu Cys Asp Glu Gly His Gly Leu Glu

1 5 10

<210> 3833

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3833

Arg Glu Ala Val Ala Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10

<210> 3834

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3834

Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys Arg Arg

1 5 10 15

<210> 3835

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3835

Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys

1 5 10 15

<210> 3836

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3836

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly

1 5 10

<210> 3837

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3837

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10

<210> 3838

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3838

Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly Arg Gly

1 5 10

<210> 3839

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3839

Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

<210> 3840

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3840

Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10 15

Leu Ser His Leu Lys Pro

20

<210> 3841

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3841

Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg

1 5 10 15

Leu Ser His Leu Lys Pro

20

<210> 3842

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3842

Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His

1 5 10

<210> 3843

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3843

Val Ala Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly Asn Ile

1 5 10 15

<210> 3844

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3844

Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10

<210> 3845

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3845

Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

<210> 3846

<211> 25

<212>PRT

<213> Homo sapiens

<400> 3846

Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Gly Pro Arg Arg

20 25

<210> 3847

<211> 6

<212>PRT

<213> Homo sapiens

<400> 3847

Val Cys Glu His Cys Asp

15

<210> 3848

<211> 35

<212>PRT

<213> Homo sapiens

<400> 3848

Val Glu Pro Lys Val Lys Lys Arg Glu Ala Val Ala Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly

20 25 30

Pro Arg Arg

35

<210> 3849

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3849

Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val

1 5 10

<210> 3850

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3850

Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly

1 5 10 15

<210> 3851

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3851

Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly

1 5 10 15

<210> 3852

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3852

Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly Arg Gly

1 5 10 15

<210> 3853

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3853

Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly Arg Gly Arg Gly

1 5 10 15

<210> 3854

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3854

Val Leu Val Asp Val Glu Arg Gly Arg Thr Val

1 5 10

<210> 3855

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3855

Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met Thr

1 5 10

<210> 3856

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3856

Tyr Ile Thr Thr Ile Ala Gly Val Met

15

<210> 3857

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3857

Tyr Lys Gln Arg Asn Gly Trp Ser His Lys Asp Leu Leu Arg Leu Ser

1 5 10 15

His Leu Lys Pro

20

<210> 3858

<211> 609

<212>PRT

<213> Homo sapiens

<400> 3858

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala

1 5 10 15

Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr

20 25 30

Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met

35 40 45

Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile

50 55 60

Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg

65 70 75 80

Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser

85 90 95

Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly

100 105 110

Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln

115 120 125

Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser

130 135 140

Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys

145 150 155 160

Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His

165 170 175

Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp

180 185 190

Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro

195 200 205

Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala

210 215 220

Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu

225 230 235 240

Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu

245 250 255

Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly

260 265 270

Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu

275 280 285

Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn

290 295 300

Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln

305 310 315 320

Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu

325 330 335

Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro

340 345 350

Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val

355 360 365

Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala

370 375 380

Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr

385 390 395 400

Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln

405 410 415

Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe

420 425 430

Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe

435 440 445

Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala

450 455 460

Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn

465 470 475 480

Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp

485 490 495

Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu

500 505 510

Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu

515 520 525

Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys

530 535 540

His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser

545 550 555 560

Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe

565 570 575

Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser

580 585 590

Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln

595 600 605

Asp

<210> 3859

<211> 119

<212>PRT

<213> Homo sapiens

<400> 3859

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr

1 5 10 15

Ile Glu Leu Lys Asn Gly Thr Gln Val His Gly Thr Ile Thr Gly Val

20 25 30

Asp Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys

35 40 45

Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser Ile Arg Gly Asn Asn

50 55 60

Ile Arg Tyr Phe Ile Leu Pro Asp Ser Leu Pro Leu Asp Thr Leu Leu

65 70 75 80

Val Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala

85 90 95

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

100 105 110

Gly Arg Gly Gly Pro Arg Arg

115

<210> 3860

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3860

Ala Ala Phe Tyr Lys Thr Phe Lys Thr Val

1 5 10

<210> 3861

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3861

Ala Glu Met Lys Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys

1 5 10 15

<210> 3862

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3862

Ala Leu Leu Arg Asn Leu Gly Lys Met Thr Ala

1 5 10

<210> 3863

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3863

Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala Lys

1 5 10

<210> 3864

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3864

Ala Met Lys Ile Ser Phe Ala Lys Lys

15

<210> 3865

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3865

Ala Pro Gly Met Arg Pro Pro

15

<210> 3866

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3866

Ala Pro Pro Pro Gly Met Arg Pro Pro Met

1 5 10

<210> 3867

<211> 19

<212>PRT

<213> Mus musculus

<400> 3867

Ala Pro Gln Gly Ser Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu

1 5 10 15

Lys His Asp

<210> 3868

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3868

Ala Thr Leu Asp Asp Ile Lys Glu Trp Leu Glu Asp Lys Gly Gln

1 5 10 15

<210> 3869

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3869

Cys Ser Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro

1 5 10

<210> 3870

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3870

Asp Arg Asn Gly Thr His Leu Asp Ala

15

<210> 3871

<211> 20

<212>PRT

<213> Mus musculus

<400> 3871

Asp Ser Cys Pro Leu Asp Cys Lys Val Tyr Val Gly Asn Leu Gly Asn

1 5 10 15

Asn Gly Asn Lys

20

<210> 3872

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3872

Glu Ala Leu Thr Lys His Phe Gln Asp

15

<210> 3873

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3873

Glu Ala Val Glu Lys Val Lys Arg Thr Lys Asp Glu Leu Glu

1 5 10

<210> 3874

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3874

Glu Lys Val Lys Arg Thr Lys Asp Glu Leu Glu Val Ile His

1 5 10

<210> 3875

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3875

Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys

1 5 10 15

<210> 3876

<211> 50

<212>PRT

<213> Homo sapiens

<400> 3876

Phe Asn Gly Thr Phe Val Lys Leu Asn Lys Ala Ser Ile Asn Met Leu

1 5 10 15

Arg Ile Val Glu Pro Tyr Ile Ala Trp Gly Tyr Pro Asn Leu Lys Ser

20 25 30

Val Asn Glu Leu Ile Tyr Lys Arg Gly Tyr Gly Lys Ile Asn Lys Lys

35 40 45

Arg Ile

50

<210> 3877

<211> 30

<212>PRT

<213> Homo sapiens

<400> 3877

Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr Asp Thr

1 5 10 15

Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro

20 25 30

<210> 3878

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3878

Gly Ile Ile Asp Leu Ile Glu Lys Arg Lys Phe Asn Gln Asn Ser Asn

1 5 10 15

Ser Thr Tyr Cys Val

20

<210> 3879

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3879

Gly Ile Met Ala Pro Pro Pro Gly Met Arg

1 5 10

<210> 3880

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3880

Gly Met Arg Pro Pro Met Gly Pro Pro Ile

1 5 10

<210> 3881

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3881

Gly Gln Ile Leu Asp Ile Leu Val Ser Arg Ser Leu Lys

1 5 10

<210> 3882

<211> 20

<212>PRT

<213> Mus musculus

<400> 3882

His His Asn Thr Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Lys

1 5 10 15

Ile Lys Val Arg

20

<210> 3883

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3883

His Lys Ala Phe Lys Gly Ser Ile

15

<210> 3884

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3884

His Lys Gly Phe Lys Gly Val Asp

15

<210> 3885

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3885

His Leu Leu Thr Asn His Leu Lys Ser Lys Glu Val Trp Lys Ala Leu

1 5 10 15

<210> 3886

<211> 20

<212>PRT

<213> Mus musculus

<400> 3886

His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys Leu Leu

1 5 10 15

Gly Lys Val Thr

20

<210> 3887

<211> 18

<212>PRT

<213> Mus musculus

<400> 3887

His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys Lys Ile

1 5 10 15

Pro Lys

<210> 3888

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3888

Ile Ile Ala Lys Met Lys Gly Thr Phe

15

<210> 3889

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3889

Ile Met Ala Pro Pro Pro Gly Met Arg Pro

1 5 10

<210> 3890

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3890

Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys Glu Thr Asp Leu

1 5 10 15

<210> 3891

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3891

Lys Ile Lys Lys Asp Glu Leu Lys Lys Ser Leu

1 5 10

<210> 3892

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3892

Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys

1 5 10 15

<210> 3893

<211> 40

<212>PRT

<213> Homo sapiens

<400> 3893

Leu Glu Lys Asp Glu Arg Glu Gln Leu Arg Ile Leu Gly Glu Lys Glu

1 5 10 15

Ala Lys Leu Ala Gln Gln Ser Gln Ala Leu Gln Glu Leu Ile Ser Glu

20 25 30

Leu Asp Arg Arg Cys His Ser Ser

35 40

<210> 3894

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3894

Leu Lys Arg Val Cys Ala Gln Ile Asn

15

<210> 3895

<211> 36

<212>PRT

<213> Homo sapiens

<400> 3895

Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu Arg Ile Leu Gly

1 5 10 15

Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala Leu Gln Glu Leu

20 25 30

Ile Ser Glu Leu

35

<210> 3896

<211> 49

<212>PRT

<213> Homo sapiens

<400> 3896

Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu Arg Ile Leu Gly

1 5 10 15

Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala Leu Gln Glu Leu

20 25 30

Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala Leu Glu Leu Leu

35 40 45

Gln

<210> 3897

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3897

Leu Arg Leu Ser His Leu Lys Pro Ser

15

<210> 3898

<211> 30

<212>PRT

<213> Homo sapiens

<400> 3898

Leu Thr Leu Pro Lys Val Glu Ala Met Asn Lys Arg Leu Gly Ser Leu

1 5 10 15

Val Asp Glu Phe Lys Glu Leu Val Tyr Pro Pro Asp Tyr Asn

20 25 30

<210> 3899

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3899

Leu Tyr Lys Glu Lys Ala Leu Ser

15

<210> 3900

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3900

Met Ala Pro Pro Pro Gly Met Arg Pro Pro

1 5 10

<210> 3901

<211> 26

<212>PRT

<213> Homo sapiens

<400> 3901

Met Glu Gly Val Glu Glu Lys Lys Lys Glu Val Pro Ala Val Pro Glu

1 5 10 15

Thr Leu Lys Lys Lys Arg Arg Asn Phe Ala

20 25

<210> 3902

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3902

Met Gly Arg Gly Ala Pro Pro Pro Gly Met Met Gly

1 5 10

<210> 3903

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3903

Met Lys Cys Gly Met Trp Gly Arg Ala

15

<210> 3904

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3904

Met Leu Arg Lys Ala Arg Arg Lys Leu Ile Tyr Glu Lys Ala Lys His

1 5 10 15

Tyr His Lys Glu Tyr Arg Gln Met

20

<210> 3905

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3905

Met Arg Pro Pro Met Gly Pro Pro Ile Gly

1 5 10

<210> 3906

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3906

Met Trp Gly Arg Ala Leu Arg Lys Ala Ile Ala

1 5 10

<210> 3907

<211> 14

<212>PRT

<213> Homo sapiens

<400> 3907

Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His Pro Phe His

1 5 10

<210> 3908

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3908

Asn Leu Asn Glu Lys Ile Lys Lys Asp

15

<210> 3909

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3909

Pro Gly Ile Met Ala Pro Pro Pro Gly Met

1 5 10

<210> 3910

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3910

Pro Gly Met Arg Pro Pro Met Gly Pro Pro

1 5 10

<210> 3911

<211> 20

<212>PRT

<213> Mus musculus

<400> 3911

Pro Gly Val Thr Val Lys Asp Val Asn Gln Gln Glu Phe Val Arg Ala

1 5 10 15

Leu Ala Ala Phe

20

<210> 3912

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3912

Pro Pro Gly Met Arg Pro Pro Met Gly Pro

1 5 10

<210> 3913

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3913

Pro Pro Pro Gly Ile Arg Gly Pro

15

<210> 3914

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3914

Pro Pro Pro Gly Met Arg Pro

15

<210> 3915

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3915

Pro Pro Pro Gly Met Arg Pro Pro

15

<210> 3916

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3916

Pro Pro Pro Gly Met Arg Pro Pro Met Gly

1 5 10

<210> 3917

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3917

Gln Glu Met Pro Leu Thr Ala Leu Leu Arg Asn Leu Gly Lys Met Thr

1 5 10 15

<210> 3918

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3918

Gln Glu Thr Pro Ala Thr Lys Lys Ala

15

<210> 3919

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3919

Arg Ala Tyr Gly Leu Lys Ser Gly Leu Lys Lys Gln Glu Leu Leu Glu

1 5 10 15

Ala Leu Thr Lys His Phe Gln Asp

20

<210> 3920

<211> 34

<212>PRT

<213> Homo sapiens

<400> 3920

Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln Lys Arg

1 5 10 15

Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser Glu Val

20 25 30

Leu Trp

<210> 3921

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3921

Arg Lys Gly His Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile

1 5 10 15

Trp Leu

<210> 3922

<211> 14

<212>PRT

<213> Mus musculus

<400> 3922

Arg Met Val Asn His Phe Ile Ala Glu Phe Lys Arg Lys His

1 5 10

<210> 3923

<211> 15

<212>PRT

<213> Mus musculus

<400> 3923

Arg Gln Val Arg Phe Tyr Asp Gly Val Ile Glu Leu Ser Leu Thr

1 5 10 15

<210> 3924

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3924

Arg Ser Gly Lys Pro Arg Gly Tyr Ala Phe

1 5 10

<210> 3925

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3925

Arg Ser Leu Lys Met Arg Gly Gln Ala Phe

1 5 10

<210> 3926

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3926

Ser Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10

<210> 3927

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3927

Ser Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly

1 5 10

<210> 3928

<211> 50

<212>PRT

<213> Homo sapiens

<400> 3928

Ser Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys

1 5 10 15

Phe Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys

20 25 30

Ser Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe

35 40 45

Gln Asp

50

<210> 3929

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3929

Ser Gln Glu Gly Arg Thr Thr Lys Gln

15

<210> 3930

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3930

Ser Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu

1 5 10 15

Glu Glu Gln Arg Gln

20

<210> 3931

<211> 10

<212>PRT

<213> Homo sapiens

<400> 3931

Ser Thr Lys Gln Ala Ala Phe Lys Ala Val

1 5 10

<210> 3932

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3932

Thr Glu Lys Leu Leu Lys Tyr Leu

15

<210> 3933

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3933

Thr Phe Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser

1 5 10

<210> 3934

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3934

Thr Tyr Tyr Ile Lys Glu Gln Lys Leu Gly Leu

1 5 10

<210> 3935

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3935

Val Glu Pro Thr Gly Lys Arg Phe Leu

15

<210> 3936

<211> 19

<212>PRT

<213> Mus musculus

<400> 3936

Val Phe Arg Arg Tyr Val Glu Val Gly Arg Val Ala Tyr Ile Ser Phe

1 5 10 15

Ser Pro His

<210> 3937

<211> 12

<212>PRT

<213> Homo sapiens

<400> 3937

Val Gly Arg Ala Thr Pro Pro Pro Gly Ile Met Ala

1 5 10

<210> 3938

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3938

Val Ser Leu Val Cys Glu Glu Lys Leu Cys Asn Glu Lys Leu Leu Lys

1 5 10 15

Lys Ala Arg Ile His

20

<210> 3939

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3939

Val Thr Lys Tyr Ile Thr Lys Gly Trp Lys Glu Val His

1 5 10

<210> 3940

<211> 17

<212>PRT

<213> Mus musculus

<400> 3940

Val Val Lys Lys Gly Thr Asp Phe Gln Leu Asn Gln Leu Glu Gly Lys

1 5 10 15

Lys

<210> 3941

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3941

Tyr Lys Thr Gly His Gly Leu Arg Gly Lys Leu Lys Trp Arg Pro

1 5 10 15

<210> 3942

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3942

Ala Ala Ala Ala Ala Pro Ala Lys

15

<210> 3943

<211> 22

<212>PRT

<213> Mus musculus

<400> 3943

Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly Ser Leu

20

<210> 3944

<211> 22

<212>PRT

<213> Homo sapiens

<400> 3944

Ala Lys Val Glu Ala Lys Glu Glu Ser Glu Glu Ser Asp Glu Asp Met

1 5 10 15

Gly Phe Gly Leu Phe Asp

20

<210> 3945

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3945

Ala Leu Gly Gly Asn Ser Ser Pro Ser Ala Lys Asp Ile Lys Lys

1 5 10 15

<210> 3946

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3946

Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys

1 5 10 15

<210> 3947

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3947

Ala Val His Gly Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys

1 5 10 15

Ala Leu Cys Trp Val Cys Ala Gln

20

<210> 3948

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3948

Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro Gly Phe Asn

1 5 10 15

<210> 3949

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3949

Cys His Ser Ser Ala Leu Glu Leu Leu Gln Glu Val Ile Ile Val

1 5 10 15

<210> 3950

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3950

Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly Lys Asn

1 5 10 15

<210> 3951

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3951

Asp Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly

1 5 10 15

<210> 3952

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3952

Asp Met Gly Phe Gly Leu Phe Asp

15

<210> 3953

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3953

Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly Ser Val Cys Ala Val

1 5 10 15

<210> 3954

<211> 24

<212>PRT

<213> Homo sapiens

<400> 3954

Glu Glu Val Thr Cys Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val

1 5 10 15

Ser Ile Glu Cys Gly His Ser Phe

20

<210> 3955

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3955

Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10 15

<210> 3956

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3956

Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu

1 5 10 15

<210> 3957

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 3957

Phe Ile Glu Trp Asn Lys Leu Arg Phe Arg Gln Gly Leu Glu Trp

1 5 10 15

<210> 3958

<211> 13

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 3958

Gly Gly Gly Arg Asp Arg Asp Arg Asp Arg Gly Gly Gly

1 5 10

<210> 3959

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3959

Gly Ile Ala Arg Val Pro Leu Ala

15

<210> 3960

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3960

Gly Ile Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu

1 5 10 15

<210> 3961

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3961

Gly Lys Ala Leu Cys Trp Val Cys Ala Gln Ser Arg Lys His Arg Asp

1 5 10 15

<210> 3962

<211> 20

<212>PRT

<213> Homo sapiens

<400> 3962

Gly Lys Ala Leu Cys Trp Val Cys Ala Gln Ser Arg Lys His Arg Asp

1 5 10 15

His Ala Met Val

20

<210> 3963

<211> 23

<212>PRT

<213> Homo sapiens

<400> 3963

Gly Lys Lys Lys Ser Lys Pro Val Asn Lys Asp Arg Tyr Ile Ser Lys

1 5 10 15

Met Phe Leu Arg Gly Asp Ser

20

<210> 3964

<211> 15

<212>PRT

<213> Human endogenous retrovirus

<400> 3964

Gly Lys Thr Cys Pro Lys Glu Ile Pro Lys Gly Ser Lys Asn Thr

1 5 10 15

<210> 3965

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3965

Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His Ile Thr Leu Asp

1 5 10 15

<210> 3966

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3966

Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile

1 5 10

<210> 3967

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3967

Gly Val Gly Gly Pro Ser Gln Gln

15

<210> 3968

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3968

Gly Val Gly Arg Ala Ala Gly Arg

15

<210> 3969

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3969

Gly Val Pro Ala Gly Val Pro Ile

15

<210> 3970

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3970

Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser Val

1 5 10 15

<210> 3971

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3971

Ile Trp Leu Trp Asn Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln

1 5 10 15

Thr

<210> 3972

<211> 23

<212>PRT

<213> Homo sapiens

<400> 3972

Lys Ala Gln Val Ala Ala Arg Gly Arg Gly Arg Gly Met Gly Arg Gly

1 5 10 15

Asn Ile Phe Gln Lys Arg Arg

20

<210> 3973

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3973

Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile Glu Ala Asp

1 5 10 15

<210> 3974

<211> 18

<212>PRT

<213> Homo sapiens

<400> 3974

Lys Glu Ile Ser Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys

1 5 10 15

Ala Val

<210> 3975

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3975

Leu Asn Gly Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly

1 5 10 15

<210> 3976

<211> 16

<212>PRT

<213> Homo sapiens

<400> 3976

Leu Ser Glu Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser

1 5 10 15

<210> 3977

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3977

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu

1 5 10

<210> 3978

<211> 31

<212>PRT

<213> Homo sapiens

<400> 3978

Met Leu Lys Asn Ala Pro Met Leu Lys Ser Met Lys Asn Lys Asn Gln

1 5 10 15

Gly Ser Gly Ala Gly Arg Gly Lys Ala Ala Ile Leu Lys Ala Gln

20 25 30

<210> 3979

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3979

Met Met Arg Lys Ala Ile Arg Gly

15

<210> 3980

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3980

Met Ser Leu Leu Asn Lys Pro Lys Ser Glu Met Thr Pro

1 5 10

<210> 3981

<211> 17

<212>PRT

<213> Homo sapiens

<400> 3981

Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser Phe Ser Glu Cys Ala

1 5 10 15

Phe

<210> 3982

<211> 21

<212>PRT

<213> Homo sapiens

<400> 3982

Asn Ser Gln Asp Gly Tyr Val Trp Gln Val Thr Asp Met Asn Arg Leu

1 5 10 15

His Arg Phe Leu Cys

20

<210> 3983

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3983

Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala

1 5 10 15

<210> 3984

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3984

Pro Ala Pro Gly Met Arg Pro Pro

15

<210> 3985

<211> 18

<212>PRT

<213> Mus musculus

<400> 3985

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val

<210> 3986

<211> 18

<212>PRT

<213> Mus musculus

<400> 3986

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val

<210> 3987

<211> 49

<212>PRT

<213> Mus musculus

<400> 3987

Pro Leu Phe Pro Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

20 25 30

Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Ser Leu Ile Tyr

35 40 45

Ile

<210> 3988

<211> 7

<212>PRT

<213> Homo sapiens

<400> 3988

Pro Pro Gly Ile Arg Gly Pro

15

<210> 3989

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3989

Pro Pro Pro Gly Met Ile Pro Pro

15

<210> 3990

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3990

Pro Pro Pro Gly Met Arg Gly Pro

15

<210> 3991

<211> 19

<212>PRT

<213> Homo sapiens

<400> 3991

Pro Gln Thr Pro Leu His Leu Gln Val Pro Pro Cys Gln Val Gly Ile

1 5 10 15

Phe Leu Asp

<210> 3992

<211> 13

<212>PRT

<213> Homo sapiens

<400> 3992

Gln Ala Leu Gly Ile Thr Thr Lys Ile Ser Arg Gly Thr

1 5 10

<210> 3993

<211> 9

<212>PRT

<213> Homo sapiens

<400> 3993

Gln Val Tyr Ile Arg Gly Ser Lys Ile

15

<210> 3994

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3994

Arg Ala Thr Trp Lys Ser Asn Tyr

15

<210> 3995

<211> 15

<212>PRT

<213> Homo sapiens

<400> 3995

Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg Ala

1 5 10 15

<210> 3996

<211> 11

<212>PRT

<213> Homo sapiens

<400> 3996

Arg Asp Arg Asp Arg Asp Arg Asp Arg Asp Arg

1 5 10

<210> 3997

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3997

Arg Asp Arg Asp Arg Asp Arg Glu

15

<210> 3998

<211> 8

<212>PRT

<213> Homo sapiens

<400> 3998

Arg Asn Pro Leu Ile Ala Gly Lys

15

<210> 3999

<211> 13

<212>PRT

<213> Bos taurus

<400> 3999

Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys Ala Val

1 5 10

<210> 4000

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4000

Ser Pro Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu

1 5 10 15

Cys

<210> 4001

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4001

Ser Gln Ala Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His

1 5 10 15

Ser

<210> 4002

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4002

Ser Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val

1 5 10 15

<210> 4003

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4003

Ser Val Leu Thr Gln Ser Val Lys Asn Asn Thr Gln

1 5 10

<210> 4004

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4004

Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu Glu Ala Arg Val

1 5 10 15

<210> 4005

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4005

Thr Gly Glu Val Tyr Arg Gly Lys Leu Ile Glu Ala Glu Asp

1 5 10

<210> 4006

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4006

Val Ala Val Ser Ala Ala Pro Gly Ser Ala Ala Pro Ala Ala Gly

1 5 10 15

<210> 4007

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4007

Val Cys Ala Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg

1 5 10 15

<210> 4008

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4008

Val His Gly Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala

1 5 10 15

<210> 4009

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4009

Trp Thr Glu Val Pro Lys Ser Gly Lys Gly Lys

1 5 10

<210> 4010

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4010

Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly Glu Leu Arg Arg Lys Gln

1 5 10 15

Glu

<210> 4011

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4011

Ala Glu Thr Arg Glu Glu Arg Met Glu Arg Lys Arg Arg Glu

1 5 10

<210> 4012

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4012

Ala Phe Gln Gln Gly Lys Ile Pro Pro

15

<210> 4013

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4013

Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val Lys Ala Glu

1 5 10 15

Lys Ser Lys Lys Lys Lys

20

<210> 4014

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4014

Glu Glu Ala Ser Gly Ser Ser Val Thr Ala Glu Glu Ala Lys Lys Phe

1 5 10 15

Leu Ala Pro Lys

20

<210> 4015

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4015

Gly Met Met Pro Ala Pro His Met

15

<210> 4016

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4016

Gly Pro Ala Pro Gly Met Arg Pro Pro

15

<210> 4017

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4017

Gly Pro Pro Met Met Arg Pro Pro Ala

15

<210> 4018

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4018

Gly Pro Pro Arg Pro Gly Met Met Pro Ala

1 5 10

<210> 4019

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4019

His Asp Ser Pro Ser Val Arg Lys

15

<210> 4020

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4020

Lys Asp Tyr Tyr Gln Lys Trp Met

15

<210> 4021

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4021

Lys Ile Pro Pro Thr Pro Phe Ser

15

<210> 4022

<211> 30

<212>PRT

<213> Homo sapiens

<400> 4022

Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser Asp Tyr

1 5 10 15

Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile

20 25 30

<210> 4023

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4023

Met Glu Arg Lys Arg Arg Glu

15

<210> 4024

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4024

Pro Phe Ser Ala Pro Pro Pro Ala

15

<210> 4025

<211> 7

<212>PRT

<213> Human herpes virus

<400> 4025

Pro Pro Pro Gly Arg Arg Pro

15

<210> 4026

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4026

Pro Pro Pro Pro Gly Met Met Pro Val

15

<210> 4027

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4027

Pro Pro Pro Pro Ser Leu Pro Gly

15

<210> 4028

<211> 32

<212>PRT

<213> Homo sapiens

<400> 4028

Arg Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp

1 5 10 15

Arg Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg

20 25 30

<210> 4029

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4029

Arg Lys Thr His Cys Ser Gly Arg Lys His

1 5 10

<210> 4030

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4030

Thr Arg Pro Gly Met Thr Arg Pro Asp Arg

1 5 10

<210> 4031

<211> 20

<212>PRT

<213> Mus musculus

<400> 4031

Tyr Tyr Cys Ala Arg Phe Leu Trp Glu Pro Tyr Ala Met Asp Tyr Trp

1 5 10 15

Gly Gln Gly Ser

20

<210> 4032

<211> 34

<212>PRT

<213> Homo sapiens

<400> 4032

Ala Val Ala Ala Thr Ala Ser Ile Ala Gly Ala Pro Thr Gln Tyr Pro

1 5 10 15

Pro Gly Arg Gly Thr Pro Pro Pro Pro Val Gly Arg Ala Thr Pro Pro

20 25 30

Pro Gly

<210> 4033

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4033

Gly Ile Met Ala Pro Pro Pro Gly Met Arg Pro Pro Met

1 5 10

<210> 4034

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4034

Gly Val Gly Gly Pro Ser Gln Gln Val Met Thr Pro Gln Gly Arg Gly

1 5 10 15

Thr Val Ala Ala Ala Ala

20

<210> 4035

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4035

Met Gly Pro Pro Ile Gly Leu Pro Pro Ala Arg

1 5 10

<210> 4036

<211> 32

<212>PRT

<213> Homo sapiens

<400> 4036

Arg Gly Thr Pro Ile Gly Met Pro Pro Pro Gly Met Arg Pro Pro Pro

1 5 10 15

Pro Gly Ile Arg Gly Pro Pro Pro Pro Gly Met Arg Pro Pro Arg Pro

20 25 30

<210> 4037

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4037

Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ser Leu Asn Lys

1 5 10 15

Trp Lys Ser Lys

20

<210> 4038

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4038

Glu Thr Pro Gly Gln Lys Tyr Lys Glu Thr Asp Leu Leu Ile Leu Phe

1 5 10 15

Lys Asp Asp Tyr

20

<210> 4039

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4039

Phe Ser Asn His Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala

1 5 10 15

Lys Glu Gly Ile

20

<210> 4040

<211> 6

<212>PRT

<213> Homo sapiens

<400> 4040

Gly Leu Glu Leu Pro Glu

15

<210> 4041

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4041

His Pro Met Leu Pro Asn Tyr Lys Asn Phe Lys Gly Thr Ile Gln Glu

1 5 10 15

Leu Gly Gln Asn

20

<210> 4042

<211> 6

<212>PRT

<213> Bos taurus

<400> 4042

Ile Arg Gly Glu Arg Ala

15

<210> 4043

<211> 4

<212>PRT

<213> Homo sapiens

<400> 4043

Lys Ile Arg Tyr

1

<210> 4044

<211> 4

<212>PRT

<213> Homo sapiens

<400> 4044

Lys Lys Ile Lys

1

<210> 4045

<211> 4

<212>PRT

<213> Homo sapiens

<400> 4045

Lys Asn Asp Lys

1

<210> 4046

<211> 4

<212>PRT

<213> Homo sapiens

<400> 4046

Leu Asp Lys Lys

1

<210> 4047

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4047

Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys Asn Glu Glu Arg

1 5 10 15

Lys Gln Asn Lys

20

<210> 4048

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4048

Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr

1 5 10

<210> 4049

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4049

Pro Ile Val Glu Thr

15

<210> 4050

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4050

Gln Phe Ile Gly Tyr Pro Ile

15

<210> 4051

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4051

Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln

1 5 10 15

Gly Thr Leu Ser

20

<210> 4052

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4052

Ser Lys Glu Gln Val

15

<210> 4053

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4053

Val Arg Gly Ala Lys Glu Gly Ile Ile Leu Phe Lys Glu Lys Ala Lys

1 5 10 15

Glu Ala Leu Gly

20

<210> 4054

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4054

Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu

1 5 10

<210> 4055

<211> 10

<212>PRT

<213> Staphylococcus aureus

<400> 4055

Glu Trp Glu Ser Thr Tyr Ser Ile Leu Gly

1 5 10

<210> 4056

<211> 50

<212>PRT

<213> Homo sapiens

<400> 4056

Gly Tyr Gly Lys Ile Asn Lys Lys Arg Ile Ala Leu Thr Asp Asn Ala

1 5 10 15

Leu Ile Ala Arg Ser Leu Gly Lys Tyr Gly Ile Ile Cys Met Glu Asp

20 25 30

Leu Ile His Glu Ile Tyr Thr Val Gly Lys Arg Phe Lys Glu Ala Asn

35 40 45

Asn Phe

50

<210> 4057

<211> 23

<212>PRT

<213> Homo sapiens

<400> 4057

Lys Met Leu Lys Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser Ile

1 5 10 15

Arg Gly Asn Arg Ile Arg Tyr

20

<210> 4058

<211> 10

<212>PRT

<213> Human herpes virus

<400> 4058

Leu Trp Asp Gln Thr Tyr Gly Val Pro Asp

1 5 10

<210> 4059

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4059

Pro Ala Val Pro Glu Thr Leu Lys Lys Lys Arg Arg Asn Phe Ala Glu

1 5 10 15

Leu Lys Ile Lys Arg Leu Arg Lys Lys

20 25

<210> 4060

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4060

Arg Met Ala Arg Met Ala Arg Lys Ala Gly Asn Phe Tyr Val Pro Ala

1 5 10 15

Glu Pro Lys

<210> 4061

<211> 10

<212>PRT

<213> Human immunodeficiency virus

<400> 4061

Thr Trp Asn Asp Thr Tyr Gly Ser Asn Asn

1 5 10

<210> 4062

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4062

Thr Tyr Gly Ile Val Leu Leu Ser Gly Val

1 5 10

<210> 4063

<211> 14

<212>PRT

<213> Bos taurus

<400> 4063

Ala Leu Gln Glu Ala Cys Glu Ala Tyr Leu Val Gly Leu Phe

1 5 10

<210> 4064

<211> 11

<212>PRT

<213> Trypanosoma cruzi

<400> 4064

Glu Asp Asp Asp Met Gly Phe Gly Leu Phe Asp

1 5 10

<210> 4065

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4065

Gly Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

1 5 10 15

Gly Gly Gly Ser Ser

20

<210> 4066

<211> 18

<212>PRT

<213> Bos taurus

<400> 4066

Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala Cys Glu Ala

1 5 10 15

Tyr Leu

<210> 4067

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4067

Thr Phe Ile Gln Phe Lys Lys Asp Leu Lys Glu

1 5 10

<210> 4068

<211> 21

<212>PRT

<213> Bos taurus

<400> 4068

Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro

1 5 10 15

Arg Lys Gln Leu Ala

20

<210> 4069

<211> 16

<212>PRT

<213> Bos taurus

<400> 4069

Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr Val Thr Ala Met

1 5 10 15

<210> 4070

<211> 18

<212>PRT

<213> Bos taurus

<400> 4070

Gly Ala Gly Ala Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr

1 5 10 15

Ala Glu

<210> 4071

<211> 7

<212>PRT

<213> Escherichia coli

<400> 4071

Ile Leu Pro Pro Pro Gly Tyr

15

<210> 4072

<211> 20

<212>PRT

<213> Bos taurus

<400> 4072

Ile Gln Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His

1 5 10 15

Ala Val Ser Glu

20

<210> 4073

<211> 15

<212>PRT

<213> Bos taurus

<400> 4073

Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala Thr

1 5 10 15

<210> 4074

<211> 21

<212>PRT

<213> Bos taurus

<400> 4074

Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile Pro

1 5 10 15

Arg His Leu Gln Leu

20

<210> 4075

<211> 16

<212>PRT

<213> Bos taurus

<400> 4075

Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys Leu Leu Gly Lys Val

1 5 10 15

<210> 4076

<211> 14

<212>PRT

<213> Bos taurus

<400> 4076

Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys Gly Lys

1 5 10

<210> 4077

<211> 15

<212>PRT

<213> Bos taurus

<400> 4077

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala

1 5 10 15

<210> 4078

<211> 16

<212>PRT

<213> Bos taurus

<400> 4078

Pro Ala Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr

1 5 10 15

<210> 4079

<211> 16

<212>PRT

<213> Bos taurus

<400> 4079

Arg Tyr Arg Pro Gly Thr Val Ala Leu Arg Glu Ile Arg Arg Tyr Gln

1 5 10 15

<210> 4080

<211> 7

<212>PRT

<213> Mus musculus

<400> 4080

Ser Pro Leu Asn Val Leu Met

15

<210> 4081

<211> 7

<212>PRT

<213> Human herpes virus

<400> 4081

Ser Pro Pro Glu Trp Leu Lys

15

<210> 4082

<211> 16

<212>PRT

<213> Bos taurus

<400> 4082

Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn

1 5 10 15

<210> 4083

<211> 15

<212>PRT

<213> Bos taurus

<400> 4083

Val Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys

1 5 10 15

<210> 4084

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4084

Ala Asp Gly Lys Lys Ile Asp Gly

15

<210> 4085

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4085

Ala Ile Ala Leu Arg Glu Tyr Arg

15

<210> 4086

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4086

Ala Ile Cys Ser Gln Cys Ser Asp

15

<210> 4087

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4087

Ala Lys Ala Lys Ala Lys Ala Lys

15

<210> 4088

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4088

Ala Leu Ala Val Thr Lys Tyr Lys Gln Arg Asn Gly Trp Ser His Lys

1 5 10 15

<210> 4089

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4089

Ala Leu Phe Ala Pro Arg Asp Pro

15

<210> 4090

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4090

Ala Ser Ala Ala Arg Leu Thr Met Met Trp

1 5 10

<210> 4091

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4091

Ala Val Glu Lys Val Lys Arg Thr Lys Asp Glu

1 5 10

<210> 4092

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4092

Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala Gly

1 5 10 15

<210> 4093

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4093

Glu Lys Asp Ser Tyr Val Val Ala Phe Ser Asp Glu Met Val Pro Cys

1 5 10 15

Pro Val Thr Thr Asp Met

20

<210> 4094

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4094

Glu Arg Met Glu Arg Lys Arg Arg Glu Lys

1 5 10

<210> 4095

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4095

Phe Thr Phe Ile Gln Phe Lys Lys Asp Leu Lys Glu Ser Met Lys

1 5 10 15

<210> 4096

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4096

Gly Thr Gln Val His Gly Thr Ile

15

<210> 4097

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4097

His Pro Ala Ile Ala Leu Arg Glu

15

<210> 4098

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4098

Ile Ala Leu Arg Glu Tyr Arg Lys

15

<210> 4099

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4099

Ile Leu Pro Asp Ser Leu Pro Leu

15

<210> 4100

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4100

Lys Asp Lys Asp Arg Asp Arg Lys Arg Arg Ser Ser Arg Ser Arg

1 5 10 15

<210> 4101

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4101

Lys Lys Ala Lys Ala Lys Ala Lys

15

<210> 4102

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4102

Lys Lys Ala Pro Ala Lys Lys Gly Glu Lys Val Pro Lys Gly Lys

1 5 10 15

<210> 4103

<211> 4

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4103

Lys Lys Lys Lys

1

<210> 4104

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4104

Leu Cys Asn Glu Lys Leu Leu Lys Lys Ala Arg Ile His Pro Phe His

1 5 10 15

<210> 4105

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4105

Leu Phe Lys Pro Pro Lys Tyr His Pro Asp Val Pro Tyr Val Lys Arg

1 5 10 15

<210> 4106

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4106

Leu Leu Val Asp Val Glu Pro Lys

15

<210> 4107

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4107

Leu Pro Met Ile Trp Ala Gln Lys Thr Asn Thr Pro

1 5 10

<210> 4108

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4108

Leu Arg Lys Phe Lys Asn Ile Ser Tyr Phe Pro Gly Lys Leu Arg

1 5 10 15

<210> 4109

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4109

Leu Thr Ala Leu Leu Arg Asn Leu

15

<210> 4110

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4110

Met Glu Glu Ser Val Asn Gln Met Gln Pro Leu Asn Glu Lys Gln Ile

1 5 10 15

Ala Asn Ser Gln Asp Gly

20

<210> 4111

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4111

Met Pro Leu Thr Ala Leu Leu Arg

15

<210> 4112

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4112

Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys Asn Arg

1 5 10

<210> 4113

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4113

Pro Ala Ile Ala Leu Arg Glu Tyr

15

<210> 4114

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4114

Pro Leu Thr Ala Leu Leu Arg Asn

15

<210> 4115

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4115

Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Ala Pro Pro Lys

1 5 10 15

<210> 4116

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4116

Arg Ala Arg Ala Arg Ala Arg Ala

15

<210> 4117

<211> 28

<212>PRT

<213> Homo sapiens

<400> 4117

Arg Glu Ala Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly

1 5 10 15

Arg Gly Arg Gly Arg Gly Arg Gly Gly Pro Arg Arg

20 25

<210> 4118

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4118

Arg Phe Leu Met Lys Leu Ser His

15

<210> 4119

<211> 8

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4119

Arg Arg Ala Arg Ala Arg Ala Arg

15

<210> 4120

<211> 4

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4120

Arg Arg Arg Arg

1

<210> 4121

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4121

Arg Arg Arg Ser Arg Glu Arg Ser

15

<210> 4122

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4122

Arg Arg Ser His Arg Ser Glu Arg

15

<210> 4123

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4123

Arg Arg Ser Arg Ser Arg Asp Lys

15

<210> 4124

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4124

Ser Glu Gly Leu Ala Ile Val Thr

15

<210> 4125

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4125

Ser Lys Leu Ile Lys Ile Phe Gln Asp His Pro Leu Gln Lys Thr Tyr

1 5 10 15

Asn

<210> 4126

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4126

Ser Arg Glu Arg Ser Lys Asp Lys

15

<210> 4127

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4127

Thr Ala Leu Leu Arg Asn Leu Gly

15

<210> 4128

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4128

Thr Leu Lys Asn Arg Glu Pro Val

15

<210> 4129

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4129

Thr Tyr Lys Thr Gly His Gly Leu Arg Gly Lys Leu Lys Trp Arg Pro

1 5 10 15

<210> 4130

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4130

Val Glu Arg Gly Arg Thr Val Lys

15

<210> 4131

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4131

Val His Pro Ala Ile Ala Leu Arg

15

<210> 4132

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4132

Val Lys Gly Trp Arg Pro Arg Arg

15

<210> 4133

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4133

Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr

1 5 10

<210> 4134

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4134

Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu

1 5 10 15

<210> 4135

<211> 15

<212>PRT

<213> Mus musculus

<400> 4135

Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys Ala Val

1 5 10 15

<210> 4136

<211> 15

<212>PRT

<213> Mus musculus

<400> 4136

Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys Ala Val Thr Lys Ala

1 5 10 15

<210> 4137

<211> 15

<212>PRT

<213> Bos taurus

<400> 4137

Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile

1 5 10 15

<210> 4138

<211> 15

<212>PRT

<213> Mus musculus

<400> 4138

Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys Glu Ser Tyr Ser Val

1 5 10 15

<210> 4139

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4139

Phe Leu Glu Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His

1 5 10 15

<210> 4140

<211> 15

<212>PRT

<213> Mus musculus

<400> 4140

Gly Gly Ala Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln

1 5 10 15

<210> 4141

<211> 15

<212>PRT

<213> Mus musculus

<400> 4141

Gly Ile Thr Lys Pro Ala Ile Arg Arg Ile Ala Arg Arg Gly Gly

1 5 10 15

<210> 4142

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4142

Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His

1 5 10 15

<210> 4143

<211> 15

<212>PRT

<213> Mus musculus

<400> 4143

Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His Arg Lys Val

1 5 10 15

<210> 4144

<211> 15

<212>PRT

<213> Mus musculus

<400> 4144

Ile Met Met Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly

1 5 10 15

<210> 4145

<211> 15

<212>PRT

<213> Mus musculus

<400> 4145

Ile Arg Arg Ile Ala Arg Arg Gly Gly Val Lys Arg Ile Ser Gly

1 5 10 15

<210> 4146

<211> 15

<212>PRT

<213> Mus musculus

<400> 4146

Ile Ser Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val

1 5 10 15

<210> 4147

<211> 15

<212>PRT

<213> Mus musculus

<400> 4147

Lys Pro Ala Ile Arg Arg Ile Ala Arg Arg Gly Gly Val Lys Arg

1 5 10 15

<210> 4148

<211> 24

<212>PRT

<213> Mus musculus

<400> 4148

Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys

1 5 10 15

Pro Ala Ile Arg Arg Ile Ala Arg

20

<210> 4149

<211> 15

<212>PRT

<213> Mus musculus

<400> 4149

Leu Gly Lys Gly Gly Ala Lys Arg His Arg Lys Val Leu Arg Asp

1 5 10 15

<210> 4150

<211> 15

<212>PRT

<213> Mus musculus

<400> 4150

Leu Lys Val Phe Leu Glu Asn Val Ile Arg Asp Ala Val Thr Tyr

1 5 10 15

<210> 4151

<211> 15

<212>PRT

<213> Mus musculus

<400> 4151

Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg Leu Ala

1 5 10 15

<210> 4152

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4152

Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg

1 5 10 15

<210> 4153

<211> 15

<212>PRT

<213> Mus musculus

<400> 4153

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys

1 5 10 15

<210> 4154

<211> 24

<212>PRT

<213> Mus musculus

<400> 4154

Pro Lys Lys Gly Ser Lys Lys Ala Val Thr Lys Ala Gln Lys Lys Asp

1 5 10 15

Gly Lys Lys Arg Lys Arg Ser Arg

20

<210> 4155

<211> 15

<212>PRT

<213> Mus musculus

<400> 4155

Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg Ser Arg Lys Glu Ser

1 5 10 15

<210> 4156

<211> 15

<212>PRT

<213> Mus musculus

<400> 4156

Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys Thr Val

1 5 10 15

<210> 4157

<211> 15

<212>PRT

<213> Mus musculus

<400> 4157

Arg Gly Val Leu Lys Val Phe Leu Glu Asn Val Ile Arg Asp Ala

1 5 10 15

<210> 4158

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4158

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala

1 5 10 15

<210> 4159

<211> 15

<212>PRT

<213> Mus musculus

<400> 4159

Ser Arg Glu Ile Gln Thr Ala Val Arg Leu Leu Leu Pro Gly Glu

1 5 10 15

<210> 4160

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4160

Tyr Ala Leu Lys Arg Gln Gly Arg Thr Leu Tyr Gly Phe Gly Gly

1 5 10 15

<210> 4161

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4161

Ala Ala Phe Gln Gln Gly Lys Ile Pro Pro

1 5 10

<210> 4162

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4162

Ala Met Pro Pro Gln Gln Leu Met

15

<210> 4163

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4163

Ala Pro Gly Met Arg Pro Pro Met Gly Gly

1 5 10

<210> 4164

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4164

Ala Thr Lys Lys Ala Val Gln Gly

15

<210> 4165

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4165

Glu Val Arg Leu Val Pro Gly Arg

15

<210> 4166

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4166

Phe Gln Gln Gly Lys Ile Pro Pro Thr Pro

1 5 10

<210> 4167

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4167

Gly Ala Met Pro Pro Gln Gln Leu

15

<210> 4168

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4168

Gly Met Ile Pro Pro Pro Gly Leu

15

<210> 4169

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4169

Gly Met Pro Pro Met Thr Gln Ala

15

<210> 4170

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4170

Gly Pro Ala Pro Gly Met Arg Pro Pro Met

1 5 10

<210> 4171

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4171

Gly Gln Pro Pro Tyr Met Pro Pro

15

<210> 4172

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4172

Ile Gly Thr Phe Lys Ala Phe Asp

15

<210> 4173

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4173

Ile Pro Pro Gly Ala Met Pro Pro

15

<210> 4174

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4174

Ile Pro Pro Pro Gly Leu Ala Pro

15

<210> 4175

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4175

Lys Pro Lys Ser Gln Glu Thr Pro

15

<210> 4176

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4176

Met Ile Pro Pro Pro Gly Leu Ala

15

<210> 4177

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4177

Met Pro Pro Met Thr Gln Ala Pro

15

<210> 4178

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4178

Met Pro Pro Pro Gly Met Ile Pro

15

<210> 4179

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4179

Met Pro Pro Gln Gln Leu Met Pro

15

<210> 4180

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4180

Met Thr Gln Ala Pro Arg Ile Met

15

<210> 4181

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4181

Pro Ala Thr Lys Lys Ala Val Gln

15

<210> 4182

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4182

Pro Gly Ala Met Pro Pro Gln Gln

15

<210> 4183

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4183

Pro Gly Met Ile Pro Pro Pro Gly

15

<210> 4184

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4184

Pro Met Thr Gln Ala Pro Arg Ile

15

<210> 4185

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4185

Pro Pro Ala Gln Pro Leu Ser Glu

15

<210> 4186

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4186

Pro Pro Gly Ala Met Pro Pro Gln

15

<210> 4187

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4187

Pro Pro Gly Met Ile Pro Pro Pro

15

<210> 4188

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4188

Pro Pro Met Thr Gln Ala Pro Arg

15

<210> 4189

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4189

Pro Pro Pro Gly Leu Ala Pro Gly

15

<210> 4190

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4190

Pro Pro Gln Gln Leu Met Pro Gly

15

<210> 4191

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4191

Pro Pro Tyr Met Pro Pro Pro Gly

15

<210> 4192

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4192

Pro Val Gly Pro Ala Pro Gly Met Arg Pro

1 5 10

<210> 4193

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4193

Pro Tyr Met Pro Pro Pro Gly Met

15

<210> 4194

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4194

Gln Pro Pro Tyr Met Pro Pro Pro

15

<210> 4195

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4195

Arg Gly Val Gly Gly Pro Ser Gln

15

<210> 4196

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4196

Thr Pro Ala Thr Lys Lys Ala Val

15

<210> 4197

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4197

Tyr Met Pro Pro Pro Gly Met Ile

15

<210> 4198

<211> 40

<212>PRT

<213> Homo sapiens

<400> 4198

Arg Arg Glu Phe Glu Val Tyr Gly Pro Ile Lys Arg Ile His Met Val

1 5 10 15

Tyr Ser Lys Arg Ser Gly Lys Pro Arg Gly Tyr Ala Phe Ile Glu Tyr

20 25 30

Glu His Glu Arg Asp Met His Ser

35 40

<210> 4199

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4199

Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys

1 5 10 15

Leu

<210> 4200

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4200

Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu

1 5 10

<210> 4201

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4201

Ala Glu Ile Glu Thr Asp Lys Ala Thr Ile Gly Phe Glu Val Gln Glu

1 5 10 15

Glu Gly

<210> 4202

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4202

Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His Ile Thr Leu

1 5 10 15

<210> 4203

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4203

Ser Ala Pro Ala Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro

1 5 10 15

Gly Thr

<210> 4204

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4204

Ala Gly Ala Gly Arg Val Arg Thr Ser Ala Arg Ala Gly Ser Thr

1 5 10 15

<210> 4205

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4205

Ala Pro Ala Pro Arg Thr Arg Tyr Pro Thr Arg Ala Pro Ser Gly

1 5 10 15

<210> 4206

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4206

Ala Thr Ala Arg Arg Lys Arg Arg Trp Ala Thr Arg Gly Pro Ala

1 5 10 15

<210> 4207

<211> 15

<212>PRT

<213> Hepatitis virus TTV

<400> 4207

Ala Val Leu Arg Ala Pro Gln Asn Pro Pro Pro Pro Gly Pro Gln

1 5 10 15

<210> 4208

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4208

Cys Ala Gly Trp Ala Leu Trp Arg Cys Ala Leu Arg Trp Ala Glu

1 5 10 15

<210> 4209

<211> 15

<212>PRT

<213> Hepatitis virus TTV

<400> 4209

Asp Glu Tyr Lys Arg Phe Met Asn Tyr Trp Thr Ala Ser Asn Glu

1 5 10 15

<210> 4210

<211> 15

<212>PRT

<213> Human herpes virus

<400> 4210

Asp Pro Val Gly His Pro Ala Ala Pro Arg Ala Pro Gly Pro Glu

1 5 10 15

<210> 4211

<211> 15

<212>PRT

<213> Hepatitis virus TTV

<400> 4211

Asp Arg Gly Glu Gly Asn Met Leu Trp Ile Asp Trp Leu Ser Lys

1 5 10 15

<210> 4212

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4212

Asp Arg Arg Arg Glu Gly Pro Asp Arg Ser Pro Arg Gln Pro Pro

1 5 10 15

<210> 4213

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4213

Gly Pro Asp Arg Ser Pro Arg Gln Pro Pro Val Leu Pro Ala Ala

1 5 10 15

<210> 4214

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4214

Gly Pro Gly Ala Gly Asp Arg Arg Arg Glu Gly Pro Asp Arg Ser

1 5 10 15

<210> 4215

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4215

His Pro Ala Phe Ala Arg Ala His Gly Glu Ala Gly Ala Gly Arg

1 5 10 15

<210> 4216

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4216

His Arg Ala Leu Ala Arg Gly Pro Pro Ala Arg Leu Gly Gly Glu

1 5 10 15

<210> 4217

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4217

Lys Arg Arg Trp Ala Thr Arg Gly Pro Ala His Pro Ala Phe Ala

1 5 10 15

<210> 4218

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4218

Leu Arg Trp Ala Glu Arg Gln Val Gly Ala Leu Gly Ala Glu Ser

1 5 10 15

<210> 4219

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4219

Leu Trp Arg Cys Ala Leu Arg Trp Ala Glu Arg Gln Val Gly Ala

1 5 10 15

<210> 4220

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4220

Pro Gln Asp Pro Arg Ser Pro Gly Pro Ala Pro Arg His Arg Arg

1 5 10 15

<210> 4221

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4221

Pro Arg Ala Pro Pro Ala Arg Ala Ser Tyr Arg Arg Phe Arg Thr

1 5 10 15

<210> 4222

<211> 15

<212>PRT

<213> Human herpes virus

<400> 4222

Pro Arg His Gly His Ser Gln Gly Pro Trp Lys Pro Trp Ser Ala

1 5 10 15

<210> 4223

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4223

Pro Arg His Arg His Pro Gln Asp Pro Arg Ser Pro Gly Pro Ala

1 5 10 15

<210> 4224

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4224

Pro Arg His Arg Arg Pro Pro Arg Pro Asp Pro Arg Ala Pro Pro

1 5 10 15

<210> 4225

<211> 15

<212>PRT

<213> Hepatitis virus TTV

<400> 4225

Pro Arg Ser Arg His Pro Gly Gly Pro Gly Thr Pro Gln Ile Arg

1 5 10 15

<210> 4226

<211> 15

<212>PRT

<213> Human adenovirus

<400> 4226

Pro Ser Arg Arg Arg Arg Arg Arg Lys Ala Thr Leu Ala Pro Ala

1 5 10 15

<210> 4227

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4227

Arg Ala His Gly Glu Ala Gly Ala Gly Arg Val Arg Thr Ser Ala

1 5 10 15

<210> 4228

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4228

Arg Ala Pro Ser Gly Pro Arg Pro Pro Ser Arg Ser Gln Ala Gln

1 5 10 15

<210> 4229

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4229

Arg Leu Gly Gly Glu Gly Pro Gly Ala Gly Asp Arg Arg Arg Glu

1 5 10 15

<210> 4230

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4230

Arg Leu Ser Pro Gly His Arg Ala Leu Ala Arg Gly Pro Pro Ala

1 5 10 15

<210> 4231

<211> 15

<212>PRT

<213> Human herpes virus

<400> 4231

Arg Val Pro Arg Ile Pro Arg Asp Pro Arg Pro Pro Arg Pro Pro

1 5 10 15

<210> 4232

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4232

Ser Pro Gly Pro Ala Pro Arg His Arg Arg Pro Pro Arg Pro Asp

1 5 10 15

<210> 4233

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4233

Ser Trp Glu Arg Arg Arg Leu Ser Pro Gly His Arg Ala Leu Ala

1 5 10 15

<210> 4234

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4234

Thr Leu Arg Pro Ala Ala Thr Ala Arg Arg Lys Arg Arg Trp Ala

1 5 10 15

<210> 4235

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4235

Thr Pro Pro Arg Ser Val Pro Arg Leu Arg Pro Arg His Arg His

1 5 10 15

<210> 4236

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4236

Thr Arg Gly Pro Ala His Pro Ala Phe Ala Arg Ala His Gly Glu

1 5 10 15

<210> 4237

<211> 15

<212>PRT

<213> Human herpes virus

<400> 4237

Val Ala Ser Arg Pro Leu Phe Pro Pro Arg Ser Pro Gly Pro Ser

1 5 10 15

<210> 4238

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4238

Val Pro Arg Leu Arg Pro Arg His Arg His Pro Gln Asp Pro Arg

1 5 10 15

<210> 4239

<211> 15

<212>PRT

<213> Hepatitis virus TTV

<400> 4239

Trp Trp Ala Arg Arg Arg Arg Arg Trp Arg Arg Trp Lys Arg Arg

1 5 10 15

<210> 4240

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4240

Ala Lys Lys Gly Glu Lys Val Pro Lys Gly Lys Lys Gly Lys Ala

1 5 10 15

<210> 4241

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4241

Ala Lys Pro Ala Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala

1 5 10 15

<210> 4242

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4242

Ala Arg Leu Ser Ala Lys Pro Ala Pro Pro Lys Pro Glu Pro Lys

1 5 10 15

<210> 4243

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4243

Glu Lys Val Pro Lys Gly Lys Lys Gly Lys Ala Asp Ala Gly Lys

1 5 10 15

<210> 4244

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4244

Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys Gly Glu Lys Val

1 5 10 15

<210> 4245

<211> 14

<212>PRT

<213> Human herpes virus

<400> 4245

Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Gly Arg Gly

1 5 10

<210> 4246

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4246

Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Pro Lys Lys

1 5 10

<210> 4247

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4247

Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro

1 5 10 15

<210> 4248

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4248

Lys Ser Pro Lys Lys Ala Lys Ala Ala Lys Pro Lys Lys Ala Pro

1 5 10 15

<210> 4249

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4249

Lys Thr Pro Lys Lys Ala Lys Lys Pro Lys Thr Pro Lys Lys Ala

1 5 10 15

<210> 4250

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4250

Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys Pro

1 5 10 15

<210> 4251

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4251

Pro Lys Arg Lys Ala Glu Gly Asp Ala Lys Gly Asp Lys Ala Lys

1 5 10 15

<210> 4252

<211> 15

<212>PRT

<213> Sus scrofa

<400> 4252

Pro Pro Lys Pro Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys

1 5 10 15

<210> 4253

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4253

Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile Lys Leu

1 5 10 15

<210> 4254

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4254

Ala Ala Ala Pro Ala Glu Glu Lys Lys Val Glu Ala Lys Lys Glu

1 5 10 15

<210> 4255

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4255

Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala Pro Ala Ala

1 5 10 15

<210> 4256

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4256

Ala Ala Lys Pro Lys Thr Ala Lys Pro Lys Ala Ala Lys Pro Lys Lys

1 5 10 15

<210> 4257

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4257

Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser Glu Glu Ser

1 5 10 15

<210> 4258

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4258

Ala Glu Glu Lys Lys Val Glu Ala Lys Lys Glu Glu Ser Glu Glu

1 5 10 15

<210> 4259

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4259

Ala Phe Asp Lys His Met Asn Leu

15

<210> 4260

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4260

Ala Gly Ala Ala Lys Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu

1 5 10 15

<210> 4261

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4261

Ala Gly Gly Pro Ala Pro Ala Ala Gly Ala Ala Pro Ala Gly Gly

1 5 10 15

<210> 4262

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4262

Ala Lys Lys Ala Gly Ala Ala Lys Ala Lys Lys Pro Ala Gly Ala Ala

1 5 10 15

<210> 4263

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4263

Ala Leu Leu Arg Asn Leu Gly Lys

15

<210> 4264

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4264

Ala Leu Arg Glu Tyr Arg Lys Lys

15

<210> 4265

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4265

Ala Pro Ala Ala Gly Ala Ala Pro Ala Gly Gly Pro Ala Pro Ser

1 5 10 15

<210> 4266

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4266

Ala Pro Lys Ser Pro Ala Lys Ala Lys Ala Val Lys Pro Lys Ala Ala

1 5 10 15

<210> 4267

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4267

Ala Pro Ser Thr Ala Ala Ala Pro Ala Glu Glu Lys Lys Val Glu

1 5 10 15

<210> 4268

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4268

Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys

1 5 10 15

<210> 4269

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4269

Ala Thr Pro Pro Pro Gly Ile Met

15

<210> 4270

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4270

Cys Asp Glu Phe Arg Lys Ile Lys

15

<210> 4271

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4271

Cys Asn Val Gly Ala Gly Gly Pro Ala Pro Ala Ala Gly Ala Ala

1 5 10 15

<210> 4272

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4272

Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu

1 5 10 15

<210> 4273

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4273

Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys Ile Ile Gln

1 5 10 15

<210> 4274

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4274

Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly Lys Asn Ile

1 5 10 15

<210> 4275

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4275

Asp Val Gln Leu Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu

1 5 10 15

<210> 4276

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4276

Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn

1 5 10 15

<210> 4277

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4277

Glu Asp Lys Ile Asn Ala Leu Ile Lys Ala Ala Gly Val Asn Val

1 5 10 15

<210> 4278

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4278

Glu Gly Pro Pro Pro Lys Asp Thr

15

<210> 4279

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4279

Glu Ile Leu Ser Asp Val Gln Leu Ile Lys Thr Gly Asp Lys Val

1 5 10 15

<210> 4280

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4280

Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe

1 5 10 15

<210> 4281

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4281

Glu Lys Thr Pro Val Lys Lys Lys Ala Arg Lys Ser Ala Gly Ala Ala

1 5 10 15

<210> 4282

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4282

Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr Thr Lys Ile

1 5 10 15

<210> 4283

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4283

Glu Leu Asn Gly Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile

1 5 10 15

<210> 4284

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4284

Glu Ser Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp

1 5 10 15

<210> 4285

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4285

Glu Tyr Arg Lys Lys Met Asp Ile

15

<210> 4286

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4286

Phe Phe Gln Ala Leu Gly Ile Thr Thr Lys Ile Ser Arg Gly Thr

1 5 10 15

<210> 4287

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4287

Phe Lys Ala Phe Asp Lys His Met

15

<210> 4288

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4288

Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala Ala Pro Ala

1 5 10 15

<210> 4289

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4289

Gly Gly Asn Ser Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu

1 5 10 15

<210> 4290

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4290

Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys

1 5 10 15

<210> 4291

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4291

Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile

1 5 10 15

<210> 4292

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4292

Gly Leu Pro Pro Ala Arg Gly Thr

15

<210> 4293

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4293

Gly Met Pro Pro Pro Gly Met Arg

15

<210> 4294

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4294

Gly Pro Pro Pro Pro Gly Met Arg

15

<210> 4295

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4295

Gly Ser Leu Ile Cys Asn Val Gly Ala Gly Gly Pro Ala Pro Ala

1 5 10 15

<210> 4296

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4296

Gly Thr Phe Lys Ala Phe Asp Lys

15

<210> 4297

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4297

Ile Gly Leu Pro Pro Ala Arg Gly

15

<210> 4298

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4298

Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln

1 5 10 15

<210> 4299

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4299

Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu

1 5 10 15

<210> 4300

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4300

Ile Gln Gln Val Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val

1 5 10 15

<210> 4301

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4301

Ile Trp Ala Gln Lys Thr Asn Thr

15

<210> 4302

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4302

Lys Ala Ala Gly Val Asn Val Glu Pro Phe Trp Pro Gly Leu Phe

1 5 10 15

<210> 4303

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4303

Lys Ala Phe Asp Lys His Met Asn

15

<210> 4304

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4304

Lys Ala Lys Lys Pro Ala Ala Ala Ala Gly Ala Lys Lys Ala Lys Ser

1 5 10 15

<210> 4305

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4305

Lys Glu Glu Ser Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu

1 5 10 15

<210> 4306

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4306

Lys Glu Ile Lys Lys Val Ala Thr Pro Lys Lys Ala Ser Lys Pro Lys

1 5 10 15

Lys

<210> 4307

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4307

Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly

1 5 10 15

<210> 4308

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4308

Lys Leu Asn Lys Lys Ala Ala Ser Gly Glu Ala Lys Pro Lys Ala Lys

1 5 10 15

<210> 4309

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4309

Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala

1 5 10 15

<210> 4310

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4310

Lys Ser Pro Lys Lys Ala Lys Ala Ala Lys Pro Lys Lys Ala Pro Lys

1 5 10 15

<210> 4311

<211> 15

<212>PRT

<213> Gallus gallus

<400> 4311

Lys Ser Arg Lys Ala Ser Lys Ala Lys Lys Val Lys Arg Ser Lys

1 5 10 15

<210> 4312

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4312

Lys Val Glu Ala Lys Glu Glu Ser Glu Glu Ser Asp Glu Asp Met

1 5 10 15

<210> 4313

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4313

Lys Val Glu Ala Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp

1 5 10 15

<210> 4314

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4314

Leu Ala Ala Leu Gly Gly Asn Ser Ser Pro Ser Ala Lys Asp Ile

1 5 10 15

<210> 4315

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4315

Leu Ala Asp Pro Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala

1 5 10 15

<210> 4316

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4316

Leu Pro Pro Ala Arg Gly Thr Pro

15

<210> 4317

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4317

Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln

1 5 10

<210> 4318

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4318

Leu Arg Glu Tyr Arg Lys Lys Met

15

<210> 4319

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4319

Met Ala Pro Pro Pro Gly Met Arg

15

<210> 4320

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4320

Met Ser Leu Arg Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr

1 5 10 15

<210> 4321

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4321

Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu

1 5 10 15

<210> 4322

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4322

Pro Ala Gly Ala Ala Lys Lys Pro Lys Lys Ala Thr Gly Ala Ala Thr

1 5 10 15

<210> 4323

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4323

Pro Ala Leu Glu Lys Leu Leu Pro His Ile Arg Gly Asn Val Gly

1 5 10 15

<210> 4324

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4324

Pro Gly Arg Gly Thr Pro Pro Pro

15

<210> 4325

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4325

Pro Pro Ala Arg Gly Thr Pro Ile

15

<210> 4326

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4326

Pro Pro Gly Arg Gly Thr Pro Pro

15

<210> 4327

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4327

Pro Pro Pro Gly Ile Met Ala Pro

15

<210> 4328

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4328

Pro Thr Gln Tyr Pro Pro Gly Arg

15

<210> 4329

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4329

Gln Gln Ile Arg Met Ser Leu Arg Gly Lys Ala Val Val Leu Met

1 5 10 15

<210> 4330

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4330

Gln Val Met Thr Pro Gln Gly Arg

15

<210> 4331

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4331

Arg Ala Thr Pro Pro Pro Gly Ile

15

<210> 4332

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4332

Arg Glu Tyr Arg Lys Lys Met Asp

15

<210> 4333

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4333

Arg Gly Thr Pro Pro Pro Pro Val

15

<210> 4334

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4334

Arg Lys Lys Met Asp Ile Pro Ala

15

<210> 4335

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4335

Arg Pro Pro Pro Pro Gly Ile Arg

15

<210> 4336

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4336

Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys Ala Leu Ala Ala Ala

1 5 10 15

<210> 4337

<211> 6

<212>PRT

<213> Gallus gallus

<400> 4337

Ser His Pro Thr Tyr Ser

15

<210> 4338

<211> 6

<212>PRT

<213> Gallus gallus

<400> 4338

Ser His Tyr Lys Val Gly

15

<210> 4339

<211> 16

<212>PRT

<213> Gallus gallus

<400> 4339

Ser Lys Pro Arg Ala Lys Ser Gly Ala Arg Lys Ser Pro Lys Lys Lys

1 5 10 15

<210> 4340

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4340

Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg Gly Lys Ala

1 5 10 15

<210> 4341

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4341

Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly

1 5 10 15

<210> 4342

<211> 6

<212>PRT

<213> Gallus gallus

<400> 4342

Ser Ser Arg Gln Ser Ile

15

<210> 4343

<211> 31

<212>PRT

<213> Gallus gallus

<400> 4343

Thr Glu Ser Leu Val Leu Ser Pro Ala Pro Ala Lys Pro Lys Arg Val

1 5 10 15

Lys Ala Ser Arg Arg Ser Ala Ser His Pro Thr Tyr Ser Glu Met

20 25 30

<210> 4344

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4344

Thr Phe Lys Ala Phe Asp Lys His

15

<210> 4345

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4345

Thr Pro Pro Pro Gly Ile Met Ala

15

<210> 4346

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4346

Thr Thr Ala Ala Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu

1 5 10 15

<210> 4347

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4347

Thr Val Ala Ser Val Pro His Ser Ile Ile Asn Gly Tyr Lys Arg

1 5 10 15

<210> 4348

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4348

Val Lys Ala Phe Leu Ala Asp Pro Ser Ala Phe Val Ala Ala Ala

1 5 10 15

<210> 4349

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4349

Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala Ile Arg Gly

1 5 10 15

<210> 4350

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4350

Val Asn Val Glu Pro Phe Trp Pro Gly Leu Phe Ala Lys Ala Leu

1 5 10 15

<210> 4351

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4351

Val Arg Gly Val Gly Gly Pro Ser

15

<210> 4352

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4352

Val Ser Ala Ala Pro Gly Ser Ala Ala Pro Ala Ala Gly Ser Ala

1 5 10 15

<210> 4353

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4353

Val Ser Glu Leu Ile Thr Lys Ala Val Ala Ala Ser Lys Glu Arg Ser

1 5 10 15

<210> 4354

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4354

Val Thr Val Thr Glu Asp Lys Ile Asn Ala Leu Ile Lys Ala Ala

1 5 10 15

<210> 4355

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4355

Tyr Arg Lys Lys Met Asp Ile Pro

15

<210> 4356

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4356

Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly Trp Thr Ser Arg

1 5 10

<210> 4357

<211> 345

<212>PRT

<213> Homo sapiens

<400> 4357

Met Ile Ser Pro Val Leu Ile Leu Phe Ser Ser Phe Leu Cys His Val

1 5 10 15

Ala Ile Ala Gly Arg Thr Cys Pro Lys Pro Asp Asp Leu Pro Phe Ser

20 25 30

Thr Val Val Pro Leu Lys Thr Phe Tyr Glu Pro Gly Glu Glu Ile Thr

35 40 45

Tyr Ser Cys Lys Pro Gly Tyr Val Ser Arg Gly Gly Met Arg Lys Phe

50 55 60

Ile Cys Pro Leu Thr Gly Leu Trp Pro Ile Asn Thr Leu Lys Cys Thr

65 70 75 80

Pro Arg Val Cys Pro Phe Ala Gly Ile Leu Glu Asn Gly Ala Val Arg

85 90 95

Tyr Thr Thr Phe Glu Tyr Pro Asn Thr Ile Ser Phe Ser Cys Asn Thr

100 105 110

Gly Phe Tyr Leu Asn Gly Ala Asp Ser Ala Lys Cys Thr Glu Glu Gly

115 120 125

Lys Trp Ser Pro Glu Leu Pro Val Cys Ala Pro Ile Ile Cys Pro Pro

130 135 140

Pro Ser Ile Pro Thr Phe Ala Thr Leu Arg Val Tyr Lys Pro Ser Ala

145 150 155 160

Gly Asn Asn Ser Leu Tyr Arg Asp Thr Ala Val Phe Glu Cys Leu Pro

165 170 175

Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys Thr Thr His Gly

180 185 190

Asn Trp Thr Lys Leu Pro Glu Cys Arg Glu Val Lys Cys Pro Phe Pro

195 200 205

Ser Arg Pro Asp Asn Gly Phe Val Asn Tyr Pro Ala Lys Pro Thr Leu

210 215 220

Tyr Tyr Lys Asp Lys Ala Thr Phe Gly Cys His Asp Gly Tyr Ser Leu

225 230 235 240

Asp Gly Pro Glu Glu Ile Glu Cys Thr Lys Leu Gly Asn Trp Ser Ala

245 250 255

Met Pro Ser Cys Lys Ala Ser Cys Lys Leu Pro Val Lys Lys Ala Thr

260 265 270

Val Val Tyr Gln Gly Glu Arg Val Lys Ile Gln Glu Lys Phe Lys Asn

275 280 285

Gly Met Leu His Gly Asp Lys Val Ser Phe Phe Cys Lys Asn Lys Glu

290 295 300

Lys Lys Cys Ser Tyr Thr Glu Asp Ala Gln Cys Ile Asp Gly Thr Ile

305 310 315 320

Glu Val Pro Lys Cys Phe Lys Glu His Ser Ser Leu Ala Phe Trp Lys

325 330 335

Thr Asp Ala Ser Asp Val Lys Pro Cys

340 345

<210> 4358

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4358

Ala Pro Ser Val Thr Leu Phe

15

<210> 4359

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4359

Ala Thr Leu Val Cys Leu Ile

15

<210> 4360

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4360

Ala Trp His Gln Gln Gln Pro

15

<210> 4361

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4361

Glu Arg Gly Leu Arg Tyr Leu

15

<210> 4362

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4362

Glu Arg Ile Leu Thr Ile Ser

15

<210> 4363

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4363

Gly Ala Ser Val Lys Val Thr

15

<210> 4364

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4364

Gly Ala Val Thr Val Ala Trp

15

<210> 4365

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4365

Gly Ser His Thr Arg Gly Asp

15

<210> 4366

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4366

Ile Arg Gly Asn Arg Ile Arg Tyr Phe Ile Leu Pro Asp Ser Leu Pro

1 5 10 15

Leu Asp Thr Ile

20

<210> 4367

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4367

Leu Met Lys Ile Asn Ser Asp

15

<210> 4368

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4368

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr

1 5 10 15

Ile Glu Leu

<210> 4369

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4369

Pro Asp Arg Phe Ser Gly Ser

15

<210> 4370

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4370

Pro Leu Asp Thr Ile Arg Val Asp Val Glu Pro Lys Val Lys Ser Lys

1 5 10 15

Lys Arg Glu Ala

20

<210> 4371

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4371

Arg Gly Tyr Asp Ser Tyr Ala

15

<210> 4372

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4372

Ser Tyr Leu Ser Leu Thr Pro

15

<210> 4373

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4373

Ser Tyr Ser Cys Gln Val Thr

15

<210> 4374

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4374

Thr Gly Val Asp Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met

1 5 10 15

Thr Leu Lys Asn

20

<210> 4375

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4375

Val Thr Ile Glu Leu Lys Asn Gly Thr Gln Val His Gly Thr Ile Thr

1 5 10 15

Gly Val Asp Val

20

<210> 4376

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4376

Trp Lys Ala Pro Ser Ser Pro

15

<210> 4377

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4377

Tyr Ala Ala Ser Ser Tyr Leu

15

<210> 4378

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4378

Tyr Cys Gln Thr Trp Gly Ser

15

<210> 4379

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4379

Tyr Asp Ser Tyr Ala Ile Ala

15

<210> 4380

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4380

Glu Val Phe Ile Ser Ala Pro Arg

15

<210> 4381

<211> 10

<212>PRT

<213> Mus musculus

<400> 4381

Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys

1 5 10

<210> 4382

<211> 30

<212>PRT

<213> Mus musculus

<400> 4382

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val Thr Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys

20 25 30

<210> 4383

<211> 21

<212>PRT

<213> Human T-lymphotropic virus

<400> 4383

Pro Pro Pro Pro Ser Ser Pro Thr His Asp Pro Pro Asp Ser Asp Pro

1 5 10 15

Gln Ile Pro Pro Pro

20

<210> 4384

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4384

Pro Gln Ile Val Pro Glu Pro Met

15

<210> 4385

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4385

Pro Thr Arg Ala Pro Ser Gly Pro Arg Pro Pro Ser Arg Ser Gln Ala

1 5 10 15

Gln Thr Pro Pro Arg

20

<210> 4386

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4386

Asp Gly Pro Pro Gly Glu Leu Gly Pro Asp

1 5 10

<210> 4387

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4387

Asp Lys Glu Arg Glu Arg Arg Arg Ser Arg

1 5 10

<210> 4388

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4388

Glu Lys Ile Glu Arg Arg Gln Gln Glu Val

1 5 10

<210> 4389

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4389

Glu Asn Gly Tyr Leu Met Glu Ala Ala Pro

1 5 10

<210> 4390

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4390

Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg

1 5 10

<210> 4391

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4391

Glu Arg Pro Gly Pro Ser Pro Leu Pro His

1 5 10

<210> 4392

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4392

Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg

1 5 10

<210> 4393

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4393

Gly Glu Arg Gly Ser Glu Arg Gly Arg Asp

1 5 10

<210> 4394

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4394

Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly

1 5 10

<210> 4395

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4395

Ile Glu Arg Arg Gln Gln Glu Val Glu Thr

1 5 10

<210> 4396

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4396

Lys Glu Glu Arg Arg Arg Ser Arg Glu Arg

1 5 10

<210> 4397

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4397

Lys Met Lys Gly Thr Phe Val Glu

15

<210> 4398

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4398

Lys Arg Gly Glu Arg Gly Ser Glu Arg Gly

1 5 10

<210> 4399

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4399

Met Glu Arg Lys Arg Arg Glu Lys Ile Glu

1 5 10

<210> 4400

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4400

Met Met Pro Val Gly Pro Ala Pro Gly Met

1 5 10

<210> 4401

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4401

Met Thr Gln Phe Leu Pro Pro Asn Leu Leu

1 5 10

<210> 4402

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4402

Pro Gly Met Met Pro Val Gly Pro Ala Pro

1 5 10

<210> 4403

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4403

Pro Gly Pro Ser Pro Leu Pro His Arg Asp

1 5 10

<210> 4404

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4404

Pro Pro Gly Glu Leu Gly Pro Asp Gly Pro

1 5 10

<210> 4405

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4405

Pro Pro Pro Gly Met Met Pro Val Gly Pro

1 5 10

<210> 4406

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4406

Pro Arg Arg Leu Gly Gly Gly Leu Gly Gly

1 5 10

<210> 4407

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4407

Pro Ser Pro Leu Pro His Arg Asp Arg Asp

1 5 10

<210> 4408

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4408

Arg Glu Glu Arg Met Glu Arg Lys Arg Arg

1 5 10

<210> 4409

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4409

Arg Glu Arg Glu Arg Arg Glu Arg Ser Arg

1 5 10

<210> 4410

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4410

Arg Glu Arg Arg Glu Arg Ser Arg Glu Arg

1 5 10

<210> 4411

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4411

Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg

1 5 10

<210> 4412

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4412

Arg Leu Gly Gly Gly Leu Gly Gly Thr Arg

1 5 10

<210> 4413

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4413

Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln

1 5 10

<210> 4414

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4414

Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys

1 5 10

<210> 4415

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4415

Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg

1 5 10

<210> 4416

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4416

Ser Arg Tyr Asp Glu Arg Pro Gly Pro Ser

1 5 10

<210> 4417

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4417

Tyr Asp Glu Arg Pro Gly Pro Ser Pro Leu

1 5 10

<210> 4418

<211> 21

<212>PRT

<213> Mus musculus

<400> 4418

Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val Ala Ala Ile Gln

1 5 10 15

Ala Glu Lys Asn Arg

20

<210> 4419

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4419

Ala Glu Val Glu Thr Asp Lys Ala Thr Val Gly Phe Glu

1 5 10

<210> 4420

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4420

Gly Pro Pro Pro Pro Gly Met Met Pro Val Gly Pro Ala Pro Gly Met

1 5 10 15

Arg Pro Pro Met Gly

20

<210> 4421

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4421

Val Gly Pro Ala Pro Gly Met Arg Pro Pro Met Gly Gly His Met Pro

1 5 10 15

Met Met

<210> 4422

<211> 14

<212>PRT

<213> Gallus gallus

<400> 4422

Asp Trp Met Glu Glu Glu Glu Gly Ala Gln Arg Glu Lys Glu

1 5 10

<210> 4423

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4423

Gly Thr Leu His Val Val Gln Arg

15

<210> 4424

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4424

Ile Ile Trp Arg Ser Thr Gln Gly

15

<210> 4425

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4425

Ile Trp Arg Ser Thr Gln Gly Val

15

<210> 4426

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4426

Leu Gly Thr Leu His Val Val Gln

15

<210> 4427

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4427

Arg Ile Ile Trp Arg Ser Thr Gln

15

<210> 4428

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4428

Arg Val Arg Val Ser Trp Ser Pro

15

<210> 4429

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4429

Arg Val Ser Trp Ser Pro Val Pro

15

<210> 4430

<211> 21

<212>PRT

<213> Gallus gallus

<400> 4430

Ser Ala Ser His Pro Thr Tyr Ser Glu Met Ile Ala Ala Ala Ile Arg

1 5 10 15

Ala Glu Lys Ser Arg

20

<210> 4431

<211> 14

<212>PRT

<213> Gallus gallus

<400> 4431

Ser Gln Lys Glu Glu Glu Glu Gly Ala Gln Arg Glu Lys Glu

1 5 10

<210> 4432

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4432

Thr Leu His Val Val Gln Arg Gly

15

<210> 4433

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4433

Val Pro Arg Ala Gln Gly Phe Leu

15

<210> 4434

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4434

Val Arg Val Ser Trp Ser Pro Val

15

<210> 4435

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4435

Glu Cys Leu Pro Gln His Ala Met Phe Gly Asn Asp Thr Ile Thr Cys

1 5 10 15

Thr Thr His Gly Asn

20

<210> 4436

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4436

Lys Leu Pro Val Lys Lys Ala Thr Val Val Tyr Gln Gly Glu Arg

1 5 10 15

<210> 4437

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4437

Leu Pro Val Lys Lys Ala Thr Val Val Tyr Gln Gly Glu Arg Val Lys

1 5 10 15

<210> 4438

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4438

Pro Val Lys Lys Ala Thr Val Val Tyr Gln Gly Glu Arg Val

1 5 10

<210> 4439

<211> 17

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4439

Ala Pro Val Cys Val Trp Glu Arg Leu Ser Pro Tyr Arg Glu Arg Cys

1 5 10 15

Val

<210> 4440

<211> 17

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4440

Ala Pro Val Cys Val Trp Glu Arg Leu Ser Pro Tyr Arg Glu Arg Cys

1 5 10 15

Val

<210> 4441

<211> 21

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4441

Ala Pro Val Cys Val Trp Glu Arg Leu Ser Pro Tyr Arg Glu Arg Cys

1 5 10 15

Val Pro Ala Glu Gly

20

<210> 4442

<211> 18

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4442

Cys His Trp Asp Pro Phe Ser Leu Ser Ala Tyr Phe Pro Gly Gly Gly

1 5 10 15

Ser Cys

<210> 4443

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4443

His Trp Asp Pro Phe Ser Leu Ser Ala Tyr Phe Pro

1 5 10

<210> 4444

<211> 12

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4444

His Trp Asp Pro Phe Ser Leu Ser Ala Tyr Phe Pro

1 5 10

<210> 4445

<211> 16

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4445

His Trp Asp Pro Phe Ser Leu Ser Ala Tyr Phe Pro Gly Gly Gly Ser

1 5 10 15

<210> 4446

<211> 22

<212>PRT

<213> Mus musculus

<400> 4446

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys

1 5 10 15

Arg His Arg Lys Val Leu

20

<210> 4447

<211> 22

<212>PRT

<213> Mus musculus

<400> 4447

Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys

1 5 10 15

Arg His Arg Lys Val Leu

20

<210> 4448

<211> 5

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4448

Asp Trp Glu Tyr Ser

15

<210> 4449

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4449

Asp Trp Glu Tyr Ser Val Trp Ser Leu Asn

1 5 10

<210> 4450

<211> 18

<212>PRT

<213> Mus musculus

<400> 4450

Leu Pro Asp Pro Tyr Gln Lys Gln Cys Asp Asp Phe Val Ala Glu Tyr

1 5 10 15

Glu Pro

<210> 4451

<211> 21

<212>PRT

<213> Mus musculus

<400> 4451

Lys Glu Gly Tyr Lys Val Arg Leu Asp Leu Asn Ile Thr Leu Glu Phe

1 5 10 15

Arg Thr Thr Ser Lys

20

<210> 4452

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4452

Pro Pro Gly Met Arg Pro Pro Met Gly Pro Met Gly Ile Pro Pro

1 5 10 15

<210> 4453

<211> 9

<212>PRT

<213> Burkholderia fungorum

<400> 4453

Arg Ala Gly Thr Asp Glu Gly Phe Gly

15

<210> 4454

<211> 17

<212>PRT

<213> Mus musculus

<400> 4454

Asp Gly Lys Trp His Thr Val Lys Thr Glu Tyr Ile Lys Arg Lys Ala

1 5 10 15

Phe

<210> 4455

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4455

Gly Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala

1 5 10

<210> 4456

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4456

Gly Ala Arg Gly Leu Thr Gly Arg Pro Gly Asp Ala

1 5 10

<210> 4457

<211> 19

<212>PRT

<213> Mus musculus

<400> 4457

Gly Arg Leu His Phe Met Phe Asp Leu Gly Lys Gly Arg Thr Lys Val

1 5 10 15

Ser His Pro

<210> 4458

<211> 17

<212>PRT

<213> Mus musculus

<400> 4458

Lys Ala Thr Pro Met Leu Lys Met Arg Thr Ser Phe His Gly Cys Ile

1 5 10 15

Lys

<210> 4459

<211> 21

<212>PRT

<213> Mus musculus

<400> 4459

Lys Asn Leu Glu Ile Ser Arg Ser Thr Phe Asp Leu Leu Arg Asn Ser

1 5 10 15

Tyr Gly Val Arg Lys

20

<210> 4460

<211> 22

<212>PRT

<213> Mus musculus

<400> 4460

Lys Gln Asn Cys Leu Ser Ser Arg Ala Ser Phe Arg Gly Cys Val Arg

1 5 10 15

Asn Leu Arg Leu Ser Arg

20

<210> 4461

<211> 22

<212>PRT

<213> Mus musculus

<400> 4461

Arg Pro Val Arg His Ala Gln Cys Arg Val Cys Asp Gly Asn Ser Thr

1 5 10 15

Asn Pro Arg Glu Arg His

20

<210> 4462

<211> 19

<212>PRT

<213> Mus musculus

<400> 4462

Thr Ser Leu Arg Lys Ala Leu Leu His Ala Pro Thr Gly Ser Tyr Ser

1 5 10 15

Asp Gly Gln

<210> 4463

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4463

Asp His Arg Ser Pro Pro Trp Leu Thr Ser Leu Leu Thr Ile Ser

1 5 10 15

<210> 4464

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4464

Asp Thr Trp Pro Thr Ala Arg Leu Thr Ser Ser Met Gln Tyr Ile

1 5 10 15

<210> 4465

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4465

Gly His Arg Tyr Thr Ser Ser Val Ser Leu Thr Glu Ala Cys Pro

1 5 10 15

<210> 4466

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4466

His Thr Tyr Thr Ser His Leu Arg Tyr Val Pro Pro Ile Ser Leu

1 5 10 15

<210> 4467

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4467

Lys Leu Thr Ser Ser Leu Arg Cys Asn Cys Pro Pro Leu Arg Phe

1 5 10 15

<210> 4468

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4468

Lys Leu Thr Ser Ser Leu Arg Tyr Asn Ser Pro Pro Leu Cys Phe

1 5 10 15

<210> 4469

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4469

Lys Ser Thr Ser Ser Leu Arg Asp Asn Ser Pro Pro Val Cys Phe

1 5 10 15

<210> 4470

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4470

Gln Ala Pro Arg Leu Met Ser Ser Leu Ser Tyr Phe Pro Gln Ser

1 5 10 15

<210> 4471

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4471

Arg Asp Gly Gln Arg Leu Thr Ser Ser Lys Thr Met Leu Pro Tyr

1 5 10 15

<210> 4472

<211> 10

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4472

Arg Leu Thr Ser Ser Leu Arg Tyr Asn Pro

1 5 10

<210> 4473

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4473

Arg Arg Thr Pro Asp Pro Ala Val Ser Pro Trp Gln Leu Thr Tyr

1 5 10 15

<210> 4474

<211> 15

<212>PRT

<213> Unknown

<220>

<223> epitope associated with systemic lupus

<400> 4474

Thr His Asp Leu Ser Ser Arg Ala Ser Ser Ser Leu Ser Tyr Asn

1 5 10 15

<210> 4475

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4475

Ala Thr Val Gln Leu Pro Gln

15

<210> 4476

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4476

Gln Pro His Ser Arg Pro Tyr

15

<210> 4477

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4477

Ala Ser Gly Phe Thr Phe Ser Asn Tyr Ala Met His Trp Val Arg

1 5 10 15

<210> 4478

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4478

Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Gly Asn Lys

1 5 10 15

<210> 4479

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4479

Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg

1 5 10 15

<210> 4480

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4480

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

1 5 10

<210> 4481

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4481

Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

1 5 10

<210> 4482

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4482

Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr

1 5 10 15

<210> 4483

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4483

Val Ala Val Ile Ser Tyr Asp Gly Gly Asn Lys Tyr Tyr Ala Asp

1 5 10 15

<210> 4484

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4484

Ala Leu Arg Glu Tyr Arg Lys Lys Met Asp Ile Pro Ala

1 5 10

<210> 4485

<211> 29

<212>PRT

<213> Homo sapiens

<400> 4485

Gly Gly Pro Pro Met Met Pro Met Met Gly Pro Pro Pro Pro Gly Met

1 5 10 15

Met Pro Val Gly Pro Ala Pro Gly Met Arg Pro Pro Met

20 25

<210> 4486

<211> 31

<212>PRT

<213> Homo sapiens

<400> 4486

His Lys Glu Asn Val Lys Asp Tyr Tyr Gln Lys Trp Met Glu Glu Gln

1 5 10 15

Ala Gln Ser Leu Ile Asp Lys Thr Thr Ala Ala Phe Gln Gln Gly

20 25 30

<210> 4487

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4487

Ala Pro Pro Asp Asp Gly Pro Pro

15

<210> 4488

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4488

Cys Glu Thr Asn Thr Gly Glu Val

15

<210> 4489

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4489

Glu Glu Glu Glu Asp Gly Glu Met

15

<210> 4490

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4490

Glu Glu Leu Gln Lys Arg Glu Glu

15

<210> 4491

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4491

Glu Ile His Ser Lys Thr Lys Ser

15

<210> 4492

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4492

Asn Thr Glu Glu Tyr Ile Asp Gly

15

<210> 4493

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4493

Pro Asp Gly Pro Asp Gly Pro Glu

15

<210> 4494

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4494

Trp Ser Lys Ala His Pro Pro Glu

15

<210> 4495

<211> 24

<212>PRT

<213> Homo sapiens

<400> 4495

Phe Cys Pro Asp Val Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser

1 5 10 15

Lys Ala Ala Gln Gln Thr Lys Gly

20

<210> 4496

<211> 26

<212>PRT

<213> Homo sapiens

<400> 4496

Phe Gly His Ile Ser Gly Gly His Ile Asn Pro Ala Val Thr Val Ala

1 5 10 15

Met Val Cys Thr Arg Lys Ile Ser Ile Ala

20 25

<210> 4497

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4497

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu

1 5 10 15

Cys Thr Arg Glu Asn Ile

20

<210> 4498

<211> 6

<212>PRT

<213> Homo sapiens

<400> 4498

Pro Pro Pro Gly Ile Arg

15

<210> 4499

<211> 6

<212>PRT

<213> Homo sapiens

<400> 4499

Pro Pro Pro Gly Met Arg

15

<210> 4500

<211> 4

<212>PRT

<213> Homo sapiens

<400> 4500

Pro Gln Gly Arg

1

<210> 4501

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4501

Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln

1 5 10 15

Pro Glu

<210> 4502

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4502

Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly Asn Pro Thr Val

1 5 10 15

Glu

<210> 4503

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4503

Pro Asp Asp Leu Pro Phe Ser Thr

15

<210> 4504

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4504

Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys Gly

1 5 10

<210> 4505

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4505

Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys

1 5 10

<210> 4506

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4506

Tyr Asn Gln Tyr Ser Gln Arg Tyr His Gln Arg Thr Asn

1 5 10

<210> 4507

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4507

Ala Asp Ser Ala Ser Ser Ser Glu Ser Glu Arg Asn Ile Thr Ile

1 5 10 15

<210> 4508

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4508

Ala Lys Ala Thr Lys Asp Val Glu Arg Asn Leu Ser Arg Asp Leu

1 5 10 15

<210> 4509

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4509

Asp Asp Lys Lys Lys Lys Glu Ala Ala Gln Lys Lys Ala Thr Glu

1 5 10 15

<210> 4510

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4510

Asp Gly Leu Arg Asn Ser Thr Gly Leu Gly Ser Gln Asn Lys Phe

1 5 10 15

<210> 4511

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4511

Asp Val Glu Arg Asn Leu Ser Arg Asp Leu Val Gln Glu Glu Glu

1 5 10 15

<210> 4512

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4512

His Tyr Glu Asn Ser Gln Arg Gly Pro Val Ser Ser Thr Ser Asp

1 5 10 15

<210> 4513

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4513

Lys Glu Ala Ala Gln Lys Lys Ala Thr Glu Gln Lys Ile Lys Val

1 5 10 15

<210> 4514

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4514

Lys Lys Ala Thr Glu Gln Lys Ile Lys Val Pro Glu Gln Ile Lys

1 5 10 15

<210> 4515

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4515

Lys Lys Lys Lys Lys Asp Asp Lys Lys Lys Lys Glu Ala Ala Gln

1 5 10 15

<210> 4516

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4516

Lys Asn Ala Val Val Ser Asp Leu Ser Glu Lys Glu Ala Trp Pro

1 5 10 15

<210> 4517

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4517

Lys Gln Leu Leu Lys Arg Gly Gln His Phe Pro Val Ile Ala Ala

1 5 10 15

<210> 4518

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4518

Lys Arg Ala Thr Ala Asn Asn Gln Gln Pro Gln Gln Gln Gln Gln

1 5 10 15

<210> 4519

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4519

Leu Ser Arg Asp Leu Val Gln Glu Glu Glu Gln Leu Met Glu Glu

1 5 10 15

<210> 4520

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4520

Met Arg Glu Leu Glu Ala Lys Ala Thr Lys Asp Val Glu Arg Asn

1 5 10 15

<210> 4521

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4521

Asn Leu Gly Ser Ala Val Lys Val Leu Asn Ser Gln Ser Glu Ser

1 5 10 15

<210> 4522

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4522

Asn Asn Gln Gln Pro Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln

1 5 10 15

<210> 4523

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4523

Asn Ser Lys Asn Gln Ser Asp Ile Asn His Ser Thr Ser Gly Ser

1 5 10 15

<210> 4524

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4524

Pro Gln Ala Leu Pro Arg Tyr Pro Arg Glu Val Pro Pro Arg Phe

1 5 10 15

<210> 4525

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4525

Pro Val Ile Ala Ala Asn Leu Gly Ser Ala Val Lys Val Leu Asn

1 5 10 15

<210> 4526

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4526

Gln Lys Ile Lys Val Pro Glu Gln Ile Lys Pro Ser Val Ser Gln

1 5 10 15

<210> 4527

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4527

Gln Leu Met Glu Glu Lys Lys Lys Lys Lys Asp Asp Lys Lys Lys

1 5 10 15

<210> 4528

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4528

Gln Pro Gln Gln Gln Pro Gln Ala Leu Pro Arg Tyr Pro Arg Glu

1 5 10 15

<210> 4529

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4529

Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln Pro Gln Ala Leu Pro

1 5 10 15

<210> 4530

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4530

Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln

1 5 10 15

<210> 4531

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4531

Gln Gln Gln Pro Gln Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln

1 5 10 15

<210> 4532

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4532

Gln Gln Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln Pro Gln Pro

1 5 10 15

<210> 4533

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4533

Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln Gln Gln Gln Pro Gln

1 5 10 15

<210> 4534

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4534

Gln Arg Gly Pro Val Ser Ser Thr Ser Asp Ser Ser Thr Asn Cys

1 5 10 15

<210> 4535

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4535

Arg His Gln Glu His Lys Gln Leu Leu Lys Arg Gly Gln His Phe

1 5 10 15

<210> 4536

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4536

Arg Asn Ile Thr Ile Met Ala Ser Gly Asn Thr Gly Gly Glu Lys

1 5 10 15

<210> 4537

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4537

Arg Tyr Pro Arg Glu Val Pro Pro Arg Phe Arg His Gln Glu His

1 5 10 15

<210> 4538

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4538

Ser Ala Leu Thr Asn Gln Gln Pro Gln Asn Asn Gly Glu Val Gln

1 5 10 15

<210> 4539

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4539

Ser Asp Ile Asn His Ser Thr Ser Gly Ser His Tyr Glu Asn Ser

1 5 10 15

<210> 4540

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4540

Ser Asn Asn Gly Thr Ser Thr Ala Thr Ser Thr Asn Asn Asn Ala

1 5 10 15

<210> 4541

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4541

Ser Ser Thr Ser Asp Ser Ser Thr Asn Cys Lys Asn Ala Val Val

1 5 10 15

<210> 4542

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4542

Ser Thr Ala Thr Ser Thr Asn Asn Asn Ala Lys Arg Ala Thr Ala

1 5 10 15

<210> 4543

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4543

Ser Thr Gly Leu Gly Ser Gln Asn Lys Phe Val Val Gly Ser Ser

1 5 10 15

<210> 4544

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4544

Thr Asn Asn Asn Ala Lys Arg Ala Thr Ala Asn Asn Gln Gln Pro

1 5 10 15

<210> 4545

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4545

Val Lys Val Leu Asn Ser Gln Ser Glu Ser Ser Ala Leu Thr Asn

1 5 10 15

<210> 4546

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4546

Val Pro Pro Arg Phe Arg His Gln Glu His Lys Gln Leu Leu Lys

1 5 10 15

<210> 4547

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4547

Val Gln Glu Glu Glu Gln Leu Met Glu Glu Lys Lys Lys Lys Lys

1 5 10 15

<210> 4548

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4548

Lys Leu Thr Ser Glu Ala Arg Gly Arg Ile Pro Val Ala Gln Lys

1 5 10 15

<210> 4549

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4549

Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu Leu Gln

1 5 10 15

Ala Ala Gly

<210> 4550

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4550

Ala Ser Thr Asn Gly Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala

1 5 10 15

Arg Val Gln

<210> 4551

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4551

Glu Asp Leu Glu Arg Leu Leu Pro His Lys Val Phe Glu Gly Asn Arg

1 5 10 15

Pro Thr Asn

<210> 4552

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4552

Phe Glu Phe Trp Asp Trp Val Gly Gly Arg Tyr Ser Leu Trp Ser Ala

1 5 10 15

Ile Gly Leu

<210> 4553

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4553

Asn Tyr Thr Glu Gly Arg Ala Val Leu His Val Ala Leu Arg Asn Arg

1 5 10 15

Ser Asn Thr

<210> 4554

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4554

Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr Thr Gly

1 5 10 15

Lys Thr Ile

<210> 4555

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4555

Tyr Leu Ala Ser Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu

1 5 10 15

Pro Arg Arg His Arg

20

<210> 4556

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4556

Pro Ala Pro Lys Lys

15

<210> 4557

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4557

Pro Ala Pro Lys Lys

15

<210> 4558

<211> 7

<212>PRT

<213> Homo sapiens

<400> 4558

Pro Ala Pro Lys Lys Gly Ser

15

<210> 4559

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4559

Pro Ala Pro Lys Lys Gly Ser Lys

15

<210> 4560

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4560

Pro Ala Pro Lys Lys Gly Ser Lys Lys

15

<210> 4561

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4561

Pro Glu Pro Ala Lys

15

<210> 4562

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4562

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val Thr Lys Ala

20

<210> 4563

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4563

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val Thr Lys Ala

20

<210> 4564

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4564

Pro Glu Pro Ala Lys Ser Ala Pro Ala Pro Lys Lys Gly Ser Lys Lys

1 5 10 15

Ala Val Thr Lys Ala

20

<210> 4565

<211> 9

<212>PRT

<213> Mus musculus

<400> 4565

Lys Thr Glu Lys Asp Pro Glu Ser Glu

15

<210> 4566

<211> 12

<212>PRT

<213> Bos taurus

<400> 4566

Ala Ala Gly Ala Val Met Arg Gly Phe Val Phe Thr

1 5 10

<210> 4567

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4567

Ile Pro Ser Thr Val Lys Ala Gly Glu Leu Glu Lys Ile

1 5 10

<210> 4568

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4568

Ile Ser Arg Cys Gln Val Cys Met Lys Lys Arg His

1 5 10

<210> 4569

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4569

Met Lys Lys Arg His

15

<210> 4570

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4570

Ser Leu Asn Pro Glu Arg Met Phe Arg Lys Pro

1 5 10

<210> 4571

<211> 36

<212>PRT

<213> Homo sapiens

<400> 4571

Ser Leu Asn Pro Glu Arg Met Phe Arg Lys Pro Ile Pro Ser Thr Val

1 5 10 15

Lys Ala Gly Glu Leu Glu Lys Ile Ile Ser Arg Cys Gln Val Cys Met

20 25 30

Lys Lys Arg His

35

<210> 4572

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4572

Thr Ala Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser

1 5 10 15

<210> 4573

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4573

Ile Ser Leu Trp Lys Gly Phe Ser Phe

15

<210> 4574

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4574

Thr Asp Ile Pro Pro Cys Pro His Gly Trp Ile Ser Leu Trp Lys

1 5 10 15

<210> 4575

<211> 20

<212>PRT

<213> Bos taurus

<400> 4575

Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser Thr Pro

1 5 10 15

Glu Pro Met Pro

20

<210> 4576

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4576

Gly Ser Pro Ala Thr Trp Thr Thr Arg

15

<210> 4577

<211> 239

<212>PRT

<213> Homo sapiens

<400> 4577

Arg Gly Asp Ser Gly Ser Pro Ala Thr Trp Thr Thr Arg Gly Phe Val

1 5 10 15

Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro Ser Cys Pro Glu Gly

20 25 30

Thr Val Pro Leu Tyr Ser Gly Phe Ser Phe Leu Phe Val Gln Gly Asn

35 40 45

Gln Arg Ala His Gly Gln Asp Leu Gly Thr Leu Gly Ser Cys Leu Gln

50 55 60

Arg Phe Thr Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys

65 70 75 80

Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser Thr Pro Ala

85 90 95

Leu Met Pro Met Asn Met Ala Pro Ile Thr Gly Arg Ala Leu Glu Pro

100 105 110

Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly Pro Ala Ile Ala Ile Ala

115 120 125

Val His Ser Gln Thr Thr Asp Ile Pro Pro Cys Pro His Gly Trp Ile

130 135 140

Ser Leu Trp Lys Gly Phe Ser Phe Ile Met Phe Thr Ser Ala Gly Ser

145 150 155 160

Glu Gly Thr Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys Leu Glu Glu

165 170 175

Phe Arg Ala Ser Pro Phe Leu Glu Cys His Gly Arg Gly Thr Cys Asn

180 185 190

Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn Pro Glu

195 200 205

Arg Met Phe Arg Lys Pro Ile Pro Ser Thr Val Lys Ala Gly Glu Leu

210 215 220

Glu Lys Ile Ile Ser Arg Cys Gln Val Cys Met Lys Lys Arg His

225 230 235

<210> 4578

<211> 15

<212>PRT

<213> Bos taurus

<400> 4578

Cys Phe Glu Gly Gln Glu Lys Ala His Asn Gln Asp Leu Gly Leu

1 5 10 15

<210> 4579

<211> 15

<212>PRT

<213> Bos taurus

<400> 4579

Cys His Gly Arg Gly Thr Cys Asn Tyr Tyr Ala Asn Ala Tyr Ser

1 5 10 15

<210> 4580

<211> 19

<212>PRT

<213> Bos taurus

<400> 4580

Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asp

1 5 10 15

Pro Lys Arg

<210> 4581

<211> 13

<212>PRT

<213> Bos taurus

<400> 4581

Cys Pro Ala Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser

1 5 10

<210> 4582

<211> 23

<212>PRT

<213> Bos taurus

<400> 4582

Cys Thr Ile Glu Arg Ser Glu Met Phe Lys Pro Thr Pro Ser Thr Leu

1 5 10 15

Lys Ala Gly Glu Leu Arg Thr

20

<210> 4583

<211> 14

<212>PRT

<213> Bos taurus

<400> 4583

Cys Tyr Tyr Ala Ser Arg Asn Asp Lys Ser Tyr Trp Leu Ser

1 5 10

<210> 4584

<211> 18

<212>PRT

<213> Bos taurus

<400> 4584

Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser

1 5 10 15

Thr Pro

<210> 4585

<211> 6

<212>PRT

<213> Bos taurus

<400> 4585

Gly Leu Gly Phe Tyr Gly

15

<210> 4586

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4586

Lys Phe Asp Val Pro Cys Gly Gly Arg Asp Cys Ser Gly Gly Cys Gln

1 5 10 15

Cys Tyr

<210> 4587

<211> 14

<212>PRT

<213> Bos taurus

<400> 4587

Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly Pro

1 5 10

<210> 4588

<211> 13

<212>PRT

<213> Bos taurus

<400> 4588

Pro Tyr Ala Leu Gly Lys Glu Glu Arg Asp Arg Tyr Arg

1 5 10

<210> 4589

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4589

Ala Ile Ala Val His Ser Gln Thr Thr Asp Ile Pro Pro Cys Pro His

1 5 10 15

Gly Trp Ile Ser

20

<210> 4590

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4590

Ala Leu Ala Ser Pro Gly Ser Cys Leu Glu Glu Phe Arg Ala Ser Pro

1 5 10 15

Phe Leu Glu Cys

20

<210> 4591

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4591

Ala Leu Met Pro Met Asn Met Ala Pro Ile Thr Gly Arg Ala Leu Glu

1 5 10 15

Pro Tyr Ile Ser

20

<210> 4592

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4592

Glu Phe Arg Ala Ser Pro Phe Leu Glu Cys His Gly Arg Gly Thr Cys

1 5 10 15

Asn Tyr Tyr Ser

20

<210> 4593

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4593

Phe Thr Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys Asn

1 5 10 15

Phe Ala Ser Arg

20

<210> 4594

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4594

His Gly Arg Gly Thr Cys Asn Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp

1 5 10 15

Leu Ala Ser Leu

20

<210> 4595

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4595

Ile Pro Pro Cys Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser

1 5 10 15

Phe Ile Met Phe

20

<210> 4596

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4596

Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser

1 5 10 15

Phe Leu Phe Val

20

<210> 4597

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4597

Lys Ile Ile Ser Arg Cys Gln Val Cys Met Lys Lys Arg His

1 5 10

<210> 4598

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4598

Leu Gly Thr Leu Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe

1 5 10 15

Leu Phe Cys Asn

20

<210> 4599

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4599

Leu Trp Lys Gly Phe Ser Phe Ile Met Phe Thr Ser Ala Gly Ser Glu

1 5 10 15

Gly Thr Gly Gln

20

<210> 4600

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4600

Leu Tyr Ser Gly Phe Ser Phe Leu Phe Val Gln Gly Asn Gln Arg Ala

1 5 10 15

His Gly Gln Asp

20

<210> 4601

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4601

Asn Asp Tyr Ser Tyr Trp Leu Ser Ile Pro Ala Leu Met Pro Met Asn

1 5 10 15

Met Ala Pro Ile

20

<210> 4602

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4602

Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn Pro Glu Arg Met Phe

1 5 10 15

Arg Lys Pro Ile

20

<210> 4603

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4603

Pro Ser Thr Val Lys Ala Gly Glu Leu Glu Lys Ile Ile Ser Arg Cys

1 5 10 15

Gln Val Cys Met

20

<210> 4604

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4604

Arg Cys Thr Val Cys Glu Gly Pro Ala Ile Ala Ile Ala Val His Ser

1 5 10 15

Gln Thr Thr Asp

20

<210> 4605

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4605

Ser Pro Ala Thr Trp Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser

1 5 10 15

Gln Thr Thr Ala

20

<210> 4606

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4606

Thr Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu

1 5 10 15

Gly Pro Ala Ile

20

<210> 4607

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4607

Thr Ser Ala Gly Ser Glu Gly Thr Gly Gln Ala Leu Ala Ser Pro Gly

1 5 10 15

Ser Cys Leu Glu

20

<210> 4608

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4608

Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro Ser Cys Pro Glu

1 5 10 15

Gly Thr Val Pro Leu

20

<210> 4609

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4609

Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp

1 5 10 15

Leu Ser Thr Pro Ala

20

<210> 4610

<211> 44

<212>PRT

<213> Homo sapiens

<400> 4610

Pro Gly Leu Lys Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala Thr Trp

1 5 10 15

Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile

20 25 30

Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser

35 40

<210> 4611

<211> 1670

<212>PRT

<213> Homo sapiens

<400> 4611

Met Ser Ala Arg Thr Ala Pro Arg Pro Gln Val Leu Leu Leu Pro Leu

1 5 10 15

Leu Leu Val Leu Leu Ala Ala Ala Pro Ala Ala Ser Lys Gly Cys Val

20 25 30

Cys Lys Asp Lys Gly Gln Cys Phe Cys Asp Gly Ala Lys Gly Glu Lys

35 40 45

Gly Glu Lys Gly Phe Pro Gly Pro Pro Gly Ser Pro Gly Gln Lys Gly

50 55 60

Phe Thr Gly Pro Glu Gly Leu Pro Gly Pro Gln Gly Pro Lys Gly Phe

65 70 75 80

Pro Gly Leu Pro Gly Leu Thr Gly Ser Lys Gly Val Arg Gly Ile Ser

85 90 95

Gly Leu Pro Gly Phe Ser Gly Ser Pro Gly Leu Pro Gly Thr Pro Gly

100 105 110

Asn Thr Gly Pro Tyr Gly Leu Val Gly Val Pro Gly Cys Ser Gly Ser

115 120 125

Lys Gly Glu Gln Gly Phe Pro Gly Leu Pro Gly Thr Pro Gly Tyr Pro

130 135 140

Gly Ile Pro Gly Ala Ala Gly Leu Lys Gly Gln Lys Gly Ala Pro Ala

145 150 155 160

Lys Glu Glu Asp Ile Glu Leu Asp Ala Lys Gly Asp Pro Gly Leu Pro

165 170 175

Gly Ala Pro Gly Pro Gln Gly Leu Pro Gly Pro Pro Gly Phe Pro Gly

180 185 190

Pro Val Gly Pro Pro Gly Pro Pro Gly Phe Phe Gly Phe Pro Gly Ala

195 200 205

Met Gly Pro Arg Gly Pro Lys Gly His Met Gly Glu Arg Val Ile Gly

210 215 220

His Lys Gly Glu Arg Gly Val Lys Gly Leu Thr Gly Pro Pro Gly Pro

225 230 235 240

Pro Gly Thr Val Ile Val Thr Leu Thr Gly Pro Asp Asn Arg Thr Asp

245 250 255

Leu Lys Gly Glu Lys Gly Asp Lys Gly Ala Met Gly Glu Pro Gly Pro

260 265 270

Pro Gly Pro Ser Gly Leu Pro Gly Glu Ser Tyr Gly Ser Glu Lys Gly

275 280 285

Ala Pro Gly Asp Pro Gly Leu Gln Gly Lys Pro Gly Lys Asp Gly Val

290 295 300

Pro Gly Phe Pro Gly Ser Glu Gly Val Lys Gly Asn Arg Gly Phe Pro

305 310 315 320

Gly Leu Met Gly Glu Tyr Gly Ile Lys Gly Gln Lys Gly Asp Ile Gly

325 330 335

Pro Pro Gly Phe Arg Gly Pro Thr Glu Tyr Tyr Asp Thr Tyr Gln Glu

340 345 350

Lys Gly Asp Glu Gly Thr Pro Gly Pro Pro Gly Pro Arg Gly Ala Arg

355 360 365

Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Val Pro Gly Ser Pro Gly

370 375 380

Ser Ser Arg Pro Gly Leu Arg Gly Ala Pro Gly Trp Pro Gly Leu Lys

385 390 395 400

Gly Ser Lys Gly Glu Arg Gly Arg Pro Gly Lys Asp Ala Met Gly Thr

405 410 415

Pro Gly Ser Pro Gly Cys Ala Gly Ser Pro Gly Leu Pro Gly Ser Pro

420 425 430

Gly Pro Pro Gly Pro Pro Gly Asp Ile Val Phe Arg Lys Gly Pro Pro

435 440 445

Gly Asp His Gly Leu Pro Gly Tyr Leu Gly Ser Pro Gly Ile Pro Gly

450 455 460

Val Asp Gly Pro Lys Gly Glu Pro Gly Leu Leu Cys Thr Gln Cys Pro

465 470 475 480

Tyr Ile Pro Gly Pro Pro Gly Leu Pro Gly Leu Pro Gly Leu His Gly

485 490 495

Val Lys Gly Ile Pro Gly Arg Gln Gly Ala Ala Gly Leu Lys Gly Ser

500 505 510

Pro Gly Ser Pro Gly Asn Thr Gly Leu Pro Gly Phe Pro Gly Phe Pro

515 520 525

Gly Ala Gln Gly Asp Pro Gly Leu Lys Gly Glu Lys Gly Glu Thr Leu

530 535 540

Gln Pro Glu Gly Gln Val Gly Val Pro Gly Asp Pro Gly Leu Arg Gly

545 550 555 560

Gln Pro Gly Arg Lys Gly Leu Asp Gly Ile Pro Gly Thr Pro Gly Val

565 570 575

Lys Gly Leu Pro Gly Pro Lys Gly Glu Leu Ala Leu Ser Gly Glu Lys

580 585 590

Gly Asp Gln Gly Pro Pro Gly Asp Pro Gly Ser Pro Gly Ser Pro Gly

595 600 605

Pro Ala Gly Pro Ala Gly Pro Pro Gly Tyr Gly Pro Gln Gly Glu Pro

610 615 620

Gly Leu Gln Gly Thr Gln Gly Val Pro Gly Ala Pro Gly Pro Pro Gly

625 630 635 640

Glu Ala Gly Pro Arg Gly Glu Leu Ser Val Ser Thr Pro Val Pro Gly

645 650 655

Pro Pro Gly Pro Pro Gly Pro Pro Gly His Pro Gly Pro Gln Gly Pro

660 665 670

Pro Gly Ile Pro Gly Ser Leu Gly Lys Cys Gly Asp Pro Gly Leu Pro

675 680 685

Gly Pro Asp Gly Glu Pro Gly Ile Pro Gly Ile Gly Phe Pro Gly Pro

690 695 700

Pro Gly Pro Lys Gly Asp Gln Gly Phe Pro Gly Thr Lys Gly Ser Leu

705 710 715 720

Gly Cys Pro Gly Lys Met Gly Glu Pro Gly Leu Pro Gly Lys Pro Gly

725 730 735

Leu Pro Gly Ala Lys Gly Glu Pro Ala Val Ala Met Pro Gly Gly Pro

740 745 750

Gly Thr Pro Gly Phe Pro Gly Glu Arg Gly Asn Ser Gly Glu His Gly

755 760 765

Glu Ile Gly Leu Pro Gly Leu Pro Gly Leu Pro Gly Thr Pro Gly Asn

770 775 780

Glu Gly Leu Asp Gly Pro Arg Gly Asp Pro Gly Gln Pro Gly Pro Pro

785 790 795 800

Gly Glu Gln Gly Pro Pro Gly Arg Cys Ile Glu Gly Pro Arg Gly Ala

805 810 815

Gln Gly Leu Pro Gly Leu Asn Gly Leu Lys Gly Gln Gln Gly Arg Arg

820 825 830

Gly Lys Thr Gly Pro Lys Gly Asp Pro Gly Ile Pro Gly Leu Asp Arg

835 840 845

Ser Gly Phe Pro Gly Glu Thr Gly Ser Pro Gly Ile Pro Gly His Gln

850 855 860

Gly Glu Met Gly Pro Leu Gly Gln Arg Gly Tyr Pro Gly Asn Pro Gly

865 870 875 880

Ile Leu Gly Pro Pro Gly Glu Asp Gly Val Ile Gly Met Met Gly Phe

885 890 895

Pro Gly Ala Ile Gly Pro Pro Gly Pro Pro Gly Asn Pro Gly Arg Pro

900 905 910

Gly Gln Arg Gly Ser Pro Gly Ile Pro Gly Val Lys Gly Gln Arg Gly

915 920 925

Thr Pro Gly Ala Lys Gly Glu Gln Gly Asp Lys Gly Asn Pro Gly Pro

930 935 940

Ser Glu Ile Ser His Val Ile Gly Asp Lys Gly Glu Pro Gly Leu Lys

945 950 955 960

Gly Phe Ala Gly Asn Pro Gly Glu Lys Gly Asn Arg Gly Val Pro Gly

965 970 975

Met Pro Gly Leu Lys Gly Leu Lys Gly Leu Pro Gly Pro Ala Gly Pro

980 985 990

Pro Gly Pro Arg Gly Asp Leu Gly Ser Thr Gly Asn Pro Gly Glu Pro

995 1000 1005

Gly Leu Arg Gly Ile Pro Gly Ser Met Gly Asn Met Gly Met Pro

1010 1015 1020

Gly Ser Lys Gly Lys Arg Gly Thr Leu Gly Phe Pro Gly Arg Ala

1025 1030 1035

Gly Arg Pro Gly Leu Pro Gly Ile His Gly Leu Gln Gly Asp Lys

1040 1045 1050

Gly Glu Pro Gly Tyr Ser Glu Gly Thr Arg Pro Gly Pro Pro Gly

1055 1060 1065

Pro Thr Gly Asp Pro Gly Leu Pro Gly Asp Met Gly Lys Lys Gly

1070 1075 1080

Glu Met Gly Gln Pro Gly Pro Pro Gly His Leu Gly Pro Ala Gly

1085 1090 1095

Pro Glu Gly Ala Pro Gly Ser Pro Gly Ser Pro Gly Leu Pro Gly

1100 1105 1110

Lys Pro Gly Pro His Gly Asp Leu Gly Phe Lys Gly Ile Lys Gly

1115 1120 1125

Leu Leu Gly Pro Pro Gly Ile Arg Gly Pro Pro Gly Leu Pro Gly

1130 1135 1140

Phe Pro Gly Ser Pro Gly Pro Met Gly Ile Arg Gly Asp Gln Gly

1145 1150 1155

Arg Asp Gly Ile Pro Gly Pro Ala Gly Glu Lys Gly Glu Thr Gly

1160 1165 1170

Leu Leu Arg Ala Pro Pro Gly Pro Arg Gly Asn Pro Gly Ala Gln

1175 1180 1185

Gly Ala Lys Gly Asp Arg Gly Ala Pro Gly Phe Pro Gly Leu Pro

1190 1195 1200

Gly Arg Lys Gly Ala Met Gly Asp Ala Gly Pro Arg Gly Pro Thr

1205 1210 1215

Gly Ile Glu Gly Phe Pro Gly Pro Pro Gly Leu Pro Gly Ala Ile

1220 1225 1230

Ile Pro Gly Gln Thr Gly Asn Arg Gly Pro Pro Gly Ser Arg Gly

1235 1240 1245

Ser Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Gly Ser His Val

1250 1255 1260

Ile Gly Ile Lys Gly Asp Lys Gly Ser Met Gly His Pro Gly Pro

1265 1270 1275

Lys Gly Pro Pro Gly Thr Ala Gly Asp Met Gly Pro Pro Gly Arg

1280 1285 1290

Leu Gly Ala Pro Gly Thr Pro Gly Leu Pro Gly Pro Arg Gly Asp

1295 1300 1305

Pro Gly Phe Gln Gly Phe Pro Gly Val Lys Gly Glu Lys Gly Asn

1310 1315 1320

Pro Gly Phe Leu Gly Ser Ile Gly Pro Pro Gly Pro Ile Gly Pro

1325 1330 1335

Lys Gly Pro Pro Gly Val Arg Gly Asp Pro Gly Thr Leu Lys Ile

1340 1345 1350

Ile Ser Leu Pro Gly Ser Pro Gly Pro Pro Gly Thr Pro Gly Glu

1355 1360 1365

Pro Gly Met Gln Gly Glu Pro Gly Pro Pro Gly Pro Pro Gly Asn

1370 1375 1380

Leu Gly Pro Cys Gly Pro Arg Gly Lys Pro Gly Lys Asp Gly Lys

1385 1390 1395

Pro Gly Thr Pro Gly Pro Ala Gly Glu Lys Gly Asn Lys Gly Ser

1400 1405 1410

Lys Gly Glu Pro Gly Pro Ala Gly Ser Asp Gly Leu Pro Gly Leu

1415 1420 1425

Lys Gly Lys Arg Gly Asp Ser Gly Ser Pro Ala Thr Trp Thr Thr

1430 1435 1440

Arg Gly Phe Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro

1445 1450 1455

Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser Phe

1460 1465 1470

Leu Phe Val Gln Gly Asn Gln Arg Ala His Gly Gln Asp Leu Gly

1475 1480 1485

Thr Leu Gly Ser Cys Leu Gln Arg Phe Thr Thr Met Pro Phe Leu

1490 1495 1500

Phe Cys Asn Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp

1505 1510 1515

Tyr Ser Tyr Trp Leu Ser Thr Pro Ala Leu Met Pro Met Asn Met

1520 1525 1530

Ala Pro Ile Thr Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys

1535 1540 1545

Thr Val Cys Glu Gly Pro Ala Ile Ala Ile Ala Val His Ser Gln

1550 1555 1560

Thr Thr Asp Ile Pro Pro Cys Pro His Gly Trp Ile Ser Leu Trp

1565 1570 1575

Lys Gly Phe Ser Phe Ile Met Phe Thr Ser Ala Gly Ser Glu Gly

1580 1585 1590

Thr Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys Leu Glu Glu Phe

1595 1600 1605

Arg Ala Ser Pro Phe Leu Glu Cys His Gly Arg Gly Thr Cys Asn

1610 1615 1620

Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn Pro

1625 1630 1635

Glu Arg Met Phe Arg Lys Pro Ile Pro Ser Thr Val Lys Ala Gly

1640 1645 1650

Glu Leu Glu Lys Ile Ile Ser Arg Cys Gln Val Cys Met Lys Lys

1655 1660 1665

Arg His

1670

<210> 4612

<211> 20

<212>PRT

<213> Mus musculus

<400> 4612

Cys Pro Gln Asp Trp Val Ser Leu Trp Lys Gly Phe Ser Phe Ile Met

1 5 10 15

Phe Thr Ser Ala

20

<210> 4613

<211> 11

<212>PRT

<213> Mus musculus

<400> 4613

Asp Trp Val Ser Leu Trp Lys Gly Phe Ser Phe

1 5 10

<210> 4614

<211> 16

<212>PRT

<213> Mycobacterium tuberculosis

<400> 4614

Asp Leu Ser Leu Leu Gly Lys Ala Arg Lys Val Val Val Thr Lys Asp

1 5 10 15

<210> 4615

<211> 15

<212>PRT

<213> Mycobacterium bovis

<400> 4615

Asn Pro Leu Gly Leu Lys Arg Gly Ile Glu Lys Ala Val Glu Lys

1 5 10 15

<210> 4616

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4616

Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys Asp

1 5 10 15

<210> 4617

<211> 13

<212>PRT

<213> Human herpes virus

<400> 4617

Ser Tyr Leu Lys Asp Ser Asp Phe Leu Asp Ala Ala Leu

1 5 10

<210> 4618

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4618

Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp

1 5 10

<210> 4619

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4619

Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr

1 5 10

<210> 4620

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4620

Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr

1 5 10

<210> 4621

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4621

Asn Pro Val Glu Ile Arg Arg Gly Val Met Leu Ala Val Asp Ala

1 5 10 15

<210> 4622

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4622

Gln Val Ser Gly Pro Glu Arg Thr Ile Pro Ile Thr Arg Glu Glu Lys

1 5 10 15

Pro Ala Val Thr Ala Ala Pro Lys Lys

20 25

<210> 4623

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4623

Asp Leu Tyr Ile Leu Met Ser His Thr Ser Gly Ser Ala Ala

1 5 10

<210> 4624

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4624

Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala Thr Glu Val

1 5 10

<210> 4625

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4625

Gly Val Tyr Leu Leu Thr Ser His Arg Thr Ala Thr Ala Ala

1 5 10

<210> 4626

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4626

Lys Ser Met Val Ile Leu Thr Ser Thr Val Thr Ala Gly Thr Ala Glu

1 5 10 15

<210> 4627

<211> 12

<212>PRT

<213> Bos taurus

<400> 4627

Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly

1 5 10

<210> 4628

<211> 15

<212>PRT

<213> Bos taurus

<400> 4628

Ala Asp Gly Ser Ser Trp Glu Gly Val Gly Val Val Pro Asp Val

1 5 10 15

<210> 4629

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4629

Gly Pro Thr His Leu Phe Gln Pro Ser Leu Val Leu Asp Met Ala Lys

1 5 10 15

Val Leu Leu Asp

20

<210> 4630

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4630

Ser Gly Ile Pro Tyr Ile Ile Ser Tyr Leu His Pro Gly Asn Thr Ile

1 5 10 15

Leu His Val Asp

20

<210> 4631

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4631

Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile Asp Arg Thr Val Leu Gly

1 5 10 15

Ile Leu Val Ser

20

<210> 4632

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4632

Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly

1 5 10

<210> 4633

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4633

Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala Thr Glu Val Pro

1 5 10 15

Phe Arg Leu Met

20

<210> 4634

<211> 16

<212>PRT

<213> Bos taurus

<400> 4634

Leu Pro Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp

1 5 10 15

<210> 4635

<211> 14

<212>PRT

<213> Bos taurus

<400> 4635

Asn Leu Tyr Leu Thr Ile Pro Thr Ala Arg Ser Val Gly Ala

1 5 10

<210> 4636

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4636

Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His Glu

1 5 10 15

Asp Thr Asn Leu

20

<210> 4637

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4637

Pro Thr Ala Arg Ser Val Gly Ala Ala Asp Gly Ser

1 5 10

<210> 4638

<211> 23

<212>PRT

<213> Bos taurus

<400> 4638

Pro Thr Ala Arg Ser Val Gly Ala Ala Asp Gly Ser Ser Trp Glu Gly

1 5 10 15

Val Gly Val Val Pro Asp Val

20

<210> 4639

<211> 14

<212>PRT

<213> Bos taurus

<400> 4639

Val Gly Ala Ala Asp Gly Ser Ser Trp Glu Gly Val Gly Val

1 5 10

<210> 4640

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4640

Tyr Gln Ile Lys Val Lys Leu Thr Val Ser Gly Phe Leu Gly Glu Leu

1 5 10 15

Thr Ser Ser Glu

20

<210> 4641

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4641

Leu Leu Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys

1 5 10 15

Ile Lys His Glu

20

<210> 4642

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4642

Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys His Glu

1 5 10 15

<210> 4643

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4643

Asp Lys Phe Val Ile Phe Leu Asp Val Lys His Phe Ser Pro Glu Asp

1 5 10 15

Leu Thr Val Lys Val Gln Asp Asp Phe

20 25

<210> 4644

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4644

Gly Leu Asp Ala Thr His Ala Glu Arg Ala Ile Pro Val Ser Arg Glu

1 5 10 15

Glu Lys Pro Thr Ser Ala Pro Ser Ser

20 25

<210> 4645

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4645

Gly Met Leu Thr Phe Cys Gly Pro Lys Ile Gln Thr Gly Leu Asp Ala

1 5 10 15

Thr His Ala Glu Arg Ala Ile Pro Val

20 25

<210> 4646

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4646

Leu Ser Ser Asp Gly Val Leu Thr Val Asn Gly Pro Arg Lys Gln Val

1 5 10 15

Ser Gly Pro Glu Arg Thr Ile Pro Ile

20 25

<210> 4647

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4647

Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp Val Ile Glu Val His

1 5 10 15

Gly Lys His Glu Glu Arg Gln Asp Glu

20 25

<210> 4648

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4648

Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp Val Lys His Phe

1 5 10 15

Ser Pro Glu Glu Leu Lys Val Lys Val

20 25

<210> 4649

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4649

Thr Val Lys Val Gln Asp Asp Phe Val Glu Ile His Gly Lys His Asn

1 5 10 15

Glu Arg Gln Asp Asp His Gly Tyr Ile

20 25

<210> 4650

<211> 14

<212>PRT

<213> Mus musculus

<400> 4650

Gln Thr Trp Glu Gly Ser Gly Val Leu Pro Cys Val Gly Thr

1 5 10

<210> 4651

<211> 20

<212>PRT

<213> Mus musculus

<400> 4651

Ser Tyr Ser Ser Ala Val Pro Leu Leu Cys Ser Tyr Phe Phe Glu Ala

1 5 10 15

Glu Pro Arg Gln

20

<210> 4652

<211> 20

<212>PRT

<213> Unknown

<220>

<223> epitope associated with autoimmune uveitis

<400> 4652

Glu Asn Ser Asp Ser Asp Tyr Asp Arg Glu Ala Leu Gln Glu Arg Leu

1 5 10 15

Ala Lys Leu Ala

20

<210> 4653

<211> 20

<212>PRT

<213> Mycobacterium leprae

<400> 4653

Glu Asn Ser Asp Ser Asp Tyr Asp Arg Glu Lys Leu Gln Glu Arg Leu

1 5 10 15

Ala Lys Leu Ala

20

<210> 4654

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4654

Leu Ser Ser Val Val Val Asp Pro Ser Ile Arg His Phe Asp Val

1 5 10 15

<210> 4655

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4655

Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly Arg Pro Asp

1 5 10 15

<210> 4656

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4656

Asp Val Gly Val Tyr Arg Ala Val Thr Pro Gln Gly Arg Pro Asp

1 5 10 15

<210> 4657

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4657

Gly Asn Arg Ile Ala Gln Trp Gln Ser Phe Gln Leu Glu Gly

1 5 10

<210> 4658

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4658

Lys Val Lys Lys Ile Tyr Leu Asp Glu Lys Arg Leu Leu Ala Gly

1 5 10 15

<210> 4659

<211> 31

<212>PRT

<213> Homo sapiens

<400> 4659

Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly

1 5 10 15

Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu

20 25 30

<210> 4660

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4660

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys

1 5 10

<210> 4661

<211> 31

<212>PRT

<213> Homo sapiens

<400> 4661

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys

1 5 10 15

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg

20 25 30

<210> 4662

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4662

Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr His

1 5 10

<210> 4663

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4663

Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp Leu Ser Thr Ala Ile Ala

1 5 10 15

Ser Arg Ser

<210> 4664

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4664

His Ala Arg Leu Arg Asp Ser Gly Arg Ala Tyr

1 5 10

<210> 4665

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4665

Cys Asn Glu Ser Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn

1 5 10 15

Ala Leu Asn Ser

20

<210> 4666

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4666

Phe Gln Asp Thr His Asn Asn Ala His Tyr Tyr Val Phe Phe Glu Glu

1 5 10 15

Gln Glu Asp Glu

20

<210> 4667

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4667

Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu Thr Lys Val

1 5 10 15

Tyr Ser Thr

<210> 4668

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4668

Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala Leu Pro

1 5 10 15

<210> 4669

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4669

Ile Gln Arg Ile Pro Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu

1 5 10 15

Ile Glu Thr

<210> 4670

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4670

Ile Thr Asp Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln

1 5 10 15

Gly Leu Cys

<210> 4671

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4671

Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His Tyr Asp

1 5 10 15

Tyr Thr Ile Cys

20

<210> 4672

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4672

Leu Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys

1 5 10 15

Asn Gln Lys Lys

20

<210> 4673

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4673

Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu Lys Phe Leu Gly Ile Phe

1 5 10 15

Asn Thr Gly

<210> 4674

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4674

Pro Pro Ala Arg Ala Leu Lys Arg Ser Leu Trp Val Glu Val Asp Leu

1 5 10 15

Leu Ile Gly Ser

20

<210> 4675

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4675

Pro Tyr Glu Phe Ser Arg Lys Val Pro Thr Phe Ala Thr Pro Trp Pro

1 5 10 15

Asp Phe Val Pro

20

<210> 4676

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4676

Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp

1 5 10 15

Asn Pro Tyr

<210> 4677

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4677

Val Asn Ala Leu Asn Ser Pro Leu His Gln Glu Tyr Glu Glu Asn Leu

1 5 10 15

Gly Asp Ser Ile

20

<210> 4678

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4678

Ala Ser Arg Ser Val Ala Asp Lys Ile Leu Asp Leu Tyr Lys His Pro

1 5 10 15

Asp Asn Ile Asp

20

<210> 4679

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4679

Asp Pro Leu Ile Arg Gly Leu Leu Ala Arg Pro Ala

1 5 10

<210> 4680

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4680

Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr

1 5 10 15

Ser Ile

<210> 4681

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4681

Phe Gln Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn

1 5 10 15

Pro Thr Val

<210> 4682

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4682

His Gly Leu Pro Gly Tyr Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro

1 5 10 15

Arg Leu Glu Thr

20

<210> 4683

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4683

His Pro Asp Asn Ile Asp Val Trp Leu Gly Gly Leu Ala Glu Asn Phe

1 5 10 15

Leu Pro Arg Ala

20

<210> 4684

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4684

His Trp Ser Ala Asp Ala Val Tyr Gln Glu Ala Arg Lys Val Val Gly

1 5 10 15

Ala Leu

<210> 4685

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4685

Ile Pro Gly Met Met Leu Glu Ala Trp Arg Glu Thr Phe Pro Gln Asp

1 5 10 15

Asp Lys Cys Gly

20

<210> 4686

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4686

Lys Phe Pro Glu Asp Phe Glu Ser Cys Asp Ser Ile Pro Gly Met Met

1 5 10 15

Leu Glu Ala Trp

20

<210> 4687

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4687

Lys Val Val Gly Ala Leu His Gln Ile Ile Thr Leu Arg Asp Tyr Ile

1 5 10 15

Pro Arg Ile

<210> 4688

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4688

Leu Ile Gly Lys Gln Met Lys Ala Leu Arg Asp Gly Asp Trp Phe Trp

1 5 10 15

Trp Glu Asn Ser

20

<210> 4689

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4689

Leu Pro Arg Leu Glu Thr Pro Ala Asp Leu Ser Thr Ala Ile Ala Ser

1 5 10 15

Arg Ser Val Ala

20

<210> 4690

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4690

Asn Phe Leu Pro Arg Ala Arg Thr Gly Pro Leu Phe Ala Cys Leu Ile

1 5 10 15

Gly Lys Gln Met

20

<210> 4691

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4691

Asn Arg Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala

1 5 10 15

Asp Ala

<210> 4692

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4692

Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu Ala Phe Gln Gln Tyr

1 5 10 15

Val Gly

<210> 4693

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4693

Arg Gly Leu Leu Ala Arg Pro Ala Lys Leu Gln Val Gln

1 5 10

<210> 4694

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4694

Thr Ala Ala Phe Arg Phe Gly His Ala Thr Ile His Pro Leu Val Arg

1 5 10 15

Arg Leu

<210> 4695

<211> 933

<212>PRT

<213> Homo sapiens

<400> 4695

Met Arg Ala Leu Ala Val Leu Ser Val Thr Leu Val Met Ala Cys Thr

1 5 10 15

Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp Gly

20 25 30

Lys Pro Glu Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg

35 40 45

Leu Val Asp Thr Ala Met Tyr Ala Thr Met Gln Arg Asn Leu Lys Lys

50 55 60

Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu Ser Phe Ser Lys Leu Pro

65 70 75 80

Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala Glu Ile Met Glu Thr

85 90 95

Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser

100 105 110

Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile Ile Ala

115 120 125

Asn Met Ser Gly Cys Leu Pro Tyr Met Leu Pro Pro Lys Cys Pro Asn

130 135 140

Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly Ala Cys Asn Asn

145 150 155 160

Arg Asp His Pro Arg Trp Gly Ala Ser Asn Thr Ala Leu Ala Arg Trp

165 170 175

Leu Pro Pro Val Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn

180 185 190

Pro Gly Phe Leu Tyr Asn Gly Phe Pro Leu Pro Pro Val Arg Glu Val

195 200 205

Thr Arg His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp

210 215 220

Arg Tyr Ser Asp Leu Leu Met Ala Trp Gly Gln Tyr Ile Asp His Asp

225 230 235 240

Ile Ala Phe Thr Pro Gln Ser Thr Ser Lys Ala Ala Phe Gly Gly Gly

245 250 255

Ala Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile

260 265 270

Gln Leu Pro Glu Glu Ala Arg Pro Ala Ala Gly Thr Ala Cys Leu Pro

275 280 285

Phe Tyr Arg Ser Ser Ala Ala Cys Gly Thr Gly Asp Gln Gly Ala Leu

290 295 300

Phe Gly Asn Leu Ser Thr Ala Asn Pro Arg Gln Gln Met Asn Gly Leu

305 310 315 320

Thr Ser Phe Leu Asp Ala Ser Thr Val Tyr Gly Ser Ser Pro Ala Leu

325 330 335

Glu Arg Gln Leu Arg Asn Trp Thr Ser Ala Glu Gly Leu Leu Arg Val

340 345 350

His Ala Arg Leu Arg Asp Ser Gly Arg Ala Tyr Leu Pro Phe Val Pro

355 360 365

Pro Arg Ala Pro Ala Ala Cys Ala Pro Glu Pro Gly Ile Pro Gly Glu

370 375 380

Thr Arg Gly Pro Cys Phe Leu Ala Gly Asp Gly Arg Ala Ser Glu Val

385 390 395 400

Pro Ser Leu Thr Ala Leu His Thr Leu Trp Leu Arg Glu His Asn Arg

405 410 415

Leu Ala Ala Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala

420 425 430

Val Tyr Gln Glu Ala Arg Lys Val Val Gly Ala Leu His Gln Ile Ile

435 440 445

Thr Leu Arg Asp Tyr Ile Pro Arg Ile Leu Gly Pro Glu Ala Phe Gln

450 455 460

Gln Tyr Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn Pro Thr

465 470 475 480

Val Ser Asn Val Phe Ser Thr Ala Ala Phe Arg Phe Gly His Ala Thr

485 490 495

Ile His Pro Leu Val Arg Arg Leu Asp Ala Ser Phe Gln Glu His Pro

500 505 510

Asp Leu Pro Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr

515 520 525

Leu Leu Arg Gly Gly Gly Leu Asp Pro Leu Ile Arg Gly Leu Leu Ala

530 535 540

Arg Pro Ala Lys Leu Gln Val Gln Asp Gln Leu Met Asn Glu Glu Leu

545 550 555 560

Thr Glu Arg Leu Phe Val Leu Ser Asn Ser Ser Thr Leu Asp Leu Ala

565 570 575

Ser Ile Asn Leu Gln Arg Gly Arg Asp His Gly Leu Pro Gly Tyr Asn

580 585 590

Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp

595 600 605

Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys Ile Leu Asp

610 615 620

Leu Tyr Lys His Pro Asp Asn Ile Asp Val Trp Leu Gly Gly Leu Ala

625 630 635 640

Glu Asn Phe Leu Pro Arg Ala Arg Thr Gly Pro Leu Phe Ala Cys Leu

645 650 655

Ile Gly Lys Gln Met Lys Ala Leu Arg Asp Gly Asp Trp Phe Trp Trp

660 665 670

Glu Asn Ser His Val Phe Thr Asp Ala Gln Arg Arg Glu Leu Glu Lys

675 680 685

His Ser Leu Ser Arg Val Ile Cys Asp Asn Thr Gly Leu Thr Arg Val

690 695 700

Pro Met Asp Ala Phe Gln Val Gly Lys Phe Pro Glu Asp Phe Glu Ser

705 710 715 720

Cys Asp Ser Ile Thr Gly Met Asn Leu Glu Ala Trp Arg Glu Thr Phe

725 730 735

Pro Gln Asp Asp Lys Cys Gly Phe Pro Glu Ser Val Glu Asn Gly Asp

740 745 750

Phe Val His Cys Glu Glu Ser Gly Arg Arg Val Leu Val Tyr Ser Cys

755 760 765

Arg His Gly Tyr Glu Leu Gln Gly Arg Glu Gln Leu Thr Cys Thr Gln

770 775 780

Glu Gly Trp Asp Phe Gln Pro Pro Leu Cys Lys Asp Val Asn Glu Cys

785 790 795 800

Ala Asp Gly Ala His Pro Pro Cys His Ala Ser Ala Arg Cys Arg Asn

805 810 815

Thr Lys Gly Gly Phe Gln Cys Leu Cys Ala Asp Pro Tyr Glu Leu Gly

820 825 830

Asp Asp Gly Arg Thr Cys Val Asp Ser Gly Arg Leu Pro Arg Val Thr

835 840 845

Trp Ile Ser Met Ser Leu Ala Ala Leu Leu Ile Gly Gly Phe Ala Gly

850 855 860

Leu Thr Ser Thr Val Ile Cys Arg Trp Thr Arg Thr Gly Thr Lys Ser

865 870 875 880

Thr Leu Pro Ile Ser Glu Thr Gly Gly Gly Thr Pro Glu Leu Arg Cys

885 890 895

Gly Lys His Gln Ala Val Gly Thr Ser Pro Gln Arg Ala Ala Ala Gln

900 905 910

Asp Ser Glu Gln Glu Ser Ala Gly Met Glu Gly Arg Asp Thr His Arg

915 920 925

Leu Pro Arg Ala Leu

930

<210> 4696

<211> 26

<212>PRT

<213> Homo sapiens

<400> 4696

Asp Asn Thr Gly Leu Thr Arg Val Pro Met Asp Ala Phe Gln Val Gly

1 5 10 15

Lys Phe Pro Glu Asp Phe Glu Ser Cys Asp

20 25

<210> 4697

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4697

Asp Ser His Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val

1 5 10 15

Cys Thr Pro Lys

20

<210> 4698

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4698

Phe Gln Gly Leu Cys Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn

1 5 10 15

Gly Phe Thr Ser

20

<210> 4699

<211> 33

<212>PRT

<213> Homo sapiens

<400> 4699

Gly Tyr Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr

1 5 10 15

Pro Ala Asp Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys

20 25 30

Ile

<210> 4700

<211> 45

<212>PRT

<213> Homo sapiens

<400> 4700

Ile Asn Leu Gln Arg Gly Arg Asp His Gly Leu Pro Gly Tyr Asn Glu

1 5 10 15

Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp Leu

20 25 30

Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys Ile

35 40 45

<210> 4701

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4701

Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser Ser Met Gln

1 5 10 15

Ser Leu Arg Gln

20

<210> 4702

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4702

Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu Thr Arg Ala Asp Leu

1 5 10 15

Ser Tyr Pro Ser

20

<210> 4703

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4703

Leu Asp Ala Val Tyr Leu Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp

1 5 10 15

Lys Asp Ala Phe

20

<210> 4704

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4704

Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly Tyr

1 5 10 15

Lys Glu Lys Ser

20

<210> 4705

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4705

Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu

1 5 10 15

Asp Ala Val Tyr

20

<210> 4706

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4706

Gln Val Gly Lys Phe Pro Glu Asp Phe Glu Ser Cys Asp

1 5 10

<210> 4707

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4707

Ser Thr Asp Asp Tyr Ala Ser Phe Ser Arg Ala Leu

1 5 10

<210> 4708

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4708

Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser Phe

1 5 10 15

Tyr Asn Leu Ser

20

<210> 4709

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4709

Tyr Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly

1 5 10 15

Gln Glu Leu Lys

20

<210> 4710

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4710

Asp Leu Tyr Thr His Ser Glu Tyr Tyr Asn His Ala Ile Asp Trp Gln

1 5 10 15

Thr Gly Pro Gly Cys

20

<210> 4711

<211> 19

<212>PRT

<213> Mus musculus

<400> 4711

Asn Thr Thr Asp Met Met Ile Phe Asp Leu Ile His Asn Tyr Asn Arg

1 5 10 15

Phe Pro Asp

<210> 4712

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4712

Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn Lys Asn

1 5 10 15

<210> 4713

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4713

Asn Lys Pro Leu Ile Thr Val Thr Asn Ser Lys

1 5 10

<210> 4714

<211> 9

<212>PRT

<213> Rattus norvegicus

<400> 4714

Pro Pro Gly Glu Gln Thr Met Gly Val

15

<210> 4715

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4715

Val Cys Thr Pro Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met

1 5 10 15

Gly Tyr Lys Phe

20

<210> 4716

<211> 50

<212>PRT

<213> Homo sapiens

<400> 4716

Ala Thr Lys Lys Glu Glu Glu Lys Lys Gly Gly Asp Arg Asn Thr Gly

1 5 10 15

Leu Ser Arg Asp Lys Asp Lys Lys Arg Glu Glu Met Lys Glu Val Ala

20 25 30

Lys Lys Glu Asp Asp Glu Lys Val Lys Gly Glu Arg Arg Asn Thr Asp

35 40 45

Thr Arg

50

<210> 4717

<211> 39

<212>PRT

<213> Homo sapiens

<400> 4717

Leu Leu Lys Glu Asn Thr Ser Leu Leu Lys Leu Gly Tyr His Phe Glu

1 5 10 15

Leu Ala Gly Pro Arg Met Thr Val Thr Asn Leu Leu Ser Arg Asn Met

20 25 30

Asp Lys Gln Arg Gln Lys Arg

35

<210> 4718

<211> 37

<212>PRT

<213> Homo sapiens

<400> 4718

Arg Gly Arg Asp Ala Ser Lys Lys Ala Leu Gly Pro Arg Arg Asn Ser

1 5 10 15

Asp Leu Gly Lys Glu Pro Lys Arg Gly Gly Leu Lys Lys Ser Phe Ser

20 25 30

Arg Asp Arg Asp Glu

35

<210> 4719

<211> 27

<212>PRT

<213> Homo sapiens

<400> 4719

Ala Asp Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp Lys Ile

1 5 10 15

Leu Asp Leu Tyr Lys His Pro Asp Asn Ile Asp

20 25

<210> 4720

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4720

Ala Phe Gln Val Gly Lys Phe Pro Glu Asp Phe Glu Ser Cys Asp Ser

1 5 10 15

Ile Pro Gly Met

20

<210> 4721

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4721

Ala His Pro Pro Cys His Ala Ser Ala Arg Cys Arg Asn Thr Lys Gly

1 5 10 15

Gly Phe Gln Cys

20

<210> 4722

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4722

Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala Val Tyr Gln

1 5 10 15

Glu Ala Arg Lys

20

<210> 4723

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4723

Ala Pro Glu Pro Gly Ile Pro Gly Glu Thr Arg Gly Pro Cys Phe Leu

1 5 10 15

Ala Gly Asp Gly

20

<210> 4724

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4724

Asp Pro Leu Ile Arg Gly Leu Leu Ala Arg Pro Ala Lys Leu Gln Val

1 5 10 15

Gln Asp Gln Leu

20

<210> 4725

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4725

Glu Glu Ser Gly Arg Arg Val Leu Val Tyr Ser Cys Arg His Gly Tyr

1 5 10 15

Glu Leu Gln Gly

20

<210> 4726

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4726

Glu Gly Trp Asp Phe Gln Pro Pro Leu Cys Lys Asp Val Asn Glu Cys

1 5 10 15

Ala Asp Gly Ala

20

<210> 4727

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4727

Glu Ser Arg Val Ser Ser Val Leu Glu Glu Ser Lys Arg Leu Val Asp

1 5 10 15

Thr Ala Met Tyr

20

<210> 4728

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4728

Phe Ser Lys Leu Pro Glu Pro Thr Ser Gly Val Ile Ala Arg Ala Ala

1 5 10 15

Glu Ile Met Glu

20

<210> 4729

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4729

Gly Gly Ala Asp Cys Gln Met Thr Cys Glu Asn Gln Asn Pro Cys Phe

1 5 10 15

Pro Ile Gln Leu Pro

20

<210> 4730

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4730

Gly Leu Trp Leu His Gln Ala Phe Phe Ser Pro Trp Thr Leu Leu Arg

1 5 10 15

Gly Gly Gly Leu

20

<210> 4731

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4731

Gly Met Asn Leu Glu Ala Trp Arg Glu Thr Phe Pro Asp Gln Asp Asp

1 5 10 15

Lys Cys Gly Phe Pro

20

<210> 4732

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4732

Gly Arg Leu Pro Arg Ala Thr Trp Ile Ser Met Ser Leu Ala Ala Leu

1 5 10 15

Leu Ile Gly Gly

20

<210> 4733

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4733

His Ser Leu Ser Arg Val Ile Cys Asp Asn Thr Gly Leu Thr Arg Val

1 5 10 15

Pro Met Asp Ala

20

<210> 4734

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4734

His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp Asp Arg Tyr

1 5 10 15

Ser Asp Leu Leu

20

<210> 4735

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4735

Lys Cys Pro Asn Thr Cys Leu Ala Asn Lys Tyr Arg Pro Ile Thr Gly

1 5 10 15

Ala Cys Asn Asn

20

<210> 4736

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4736

Leu Pro Ile Ser Glu Thr Gly Gly Gly Thr Pro Glu Leu Arg Cys Gly

1 5 10 15

Lys His Gln Ala

20

<210> 4737

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4737

Met Glu Thr Ser Ile Gln Ala Met Lys Arg Lys Val Asn Leu Lys Thr

1 5 10 15

Gln Gln Ser Gln

20

<210> 4738

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4738

Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala

1 5 10 15

Asp Leu Ser Thr

20

<210> 4739

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4739

Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu Thr Pro Ala

1 5 10 15

Asp Leu Ser Thr Ala Ile

20

<210> 4740

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4740

Asn Ile Phe Glu Tyr Gln Val Asp Ala Gln Pro Leu

1 5 10

<210> 4741

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4741

Pro Cys Phe Leu Ala Gly Asp Gly Arg Ala Ser Glu Val Pro Ser Leu

1 5 10 15

Thr Ala Leu His

20

<210> 4742

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4742

Pro Gly Tyr Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu

1 5 10 15

Thr Pro Ala Asp Leu Ser Thr Ala Ile

20 25

<210> 4743

<211> 45

<212>PRT

<213> Homo sapiens

<400> 4743

Pro Gly Tyr Asn Glu Trp Arg Glu Phe Cys Gly Leu Pro Arg Leu Glu

1 5 10 15

Thr Pro Ala Asp Leu Ser Thr Ala Ile Ala Ser Arg Ser Val Ala Asp

20 25 30

Lys Ile Leu Asp Leu Tyr Lys His Pro Asp Asn Ile Asp

35 40 45

<210> 4744

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4744

Gln Glu Ser Ala Gly Met Glu Gly Arg Asp Thr His Arg Leu Pro Arg

1 5 10 15

Ala Leu

<210> 4745

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4745

Gln Gln Ser Gln His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser

1 5 10 15

Ile Ile Ala Asn

20

<210> 4746

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4746

Gln Arg Asn Leu Lys Lys Arg Gly Ile Leu Ser Pro Ala Gln Leu Leu

1 5 10 15

Ser Phe Ser Lys

20

<210> 4747

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4747

Arg Pro Ile Thr Gly Ala Cys Asn Asn Arg Asp His Pro Arg Trp Gly

1 5 10 15

Ala Ser Asn Thr

20

<210> 4748

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4748

Thr Glu Ala Phe Phe Pro Phe Ile Ser Arg Gly Lys Glu Leu Leu Trp

1 5 10 15

Gly Lys Pro Glu

20

<210> 4749

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4749

Val Gly Pro Tyr Glu Gly Tyr Asp Ser Thr Ala Asn Pro Thr Val Ser

1 5 10 15

Asn Val Phe Ser

20

<210> 4750

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4750

Tyr Glu Asp Gly Phe Ser Gln Pro Arg Gly Trp Asn Pro Gly Phe Leu

1 5 10 15

Tyr Asn Gly Phe

20

<210> 4751

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4751

Tyr Glu Leu Gln Gly Arg Glu Gln Leu Thr Cys Thr Gln Glu Gly Trp

1 5 10 15

Asp Phe Gln Pro

20

<210> 4752

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4752

Ala Leu Lys Ala Leu Asn Ala His Trp Ser Ala Asp Ala Val Tyr

1 5 10 15

<210> 4753

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4753

Ala Met Lys Arg Lys Val Asn Leu Lys Thr Gln Gln Ser Gln His Pro

1 5 10 15

Thr Asp Ala Leu

20

<210> 4754

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4754

Gly Leu Pro Arg Leu Glu Thr Pro Ala Asp Leu Ser Thr Ala Ile Ala

1 5 10 15

Ser Arg

<210> 4755

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4755

His Pro Thr Asp Ala Leu Ser Glu Asp Leu Leu Ser Ile

1 5 10

<210> 4756

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4756

His Val Ile Gln Val Ser Asn Glu Val Val Thr Asp Asp

1 5 10

<210> 4757

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4757

Ile Ala Ser Arg Ser Val Ala Asp Lys Ile Leu Asp Leu Tyr Lys

1 5 10 15

<210> 4758

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4758

Leu Tyr Lys His Pro Asp Asn Ile Asp Val Trp Leu Gly Gly Leu Ala

1 5 10 15

Glu Asn Phe Leu

20

<210> 4759

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4759

Met Thr Cys Glu Asn Gln Asn Pro Cys Phe Pro Ile Gln Leu Pro

1 5 10 15

<210> 4760

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4760

Val Gly Ala Leu His Gln Ile Ile Thr Leu Arg Asp Tyr Ile Pro Arg

1 5 10 15

Ile Leu

<210> 4761

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4761

Leu Val Val Tyr Pro Trp Thr Gln Arg Phe

1 5 10

<210> 4762

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4762

Ala Ala Gly Leu Leu Ser Thr Tyr Arg Ala Phe Leu Ser Ser His

1 5 10 15

<210> 4763

<211> 27

<212>PRT

<213> Homo sapiens

<400> 4763

Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu

1 5 10 15

Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu

20 25

<210> 4764

<211> 32

<212>PRT

<213> Homo sapiens

<400> 4764

Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu

1 5 10 15

Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg

20 25 30

<210> 4765

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4765

Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu

1 5 10 15

Ala Leu Glu Arg Met

20

<210> 4766

<211> 29

<212>PRT

<213> Homo sapiens

<400> 4766

Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu

1 5 10 15

Ala Leu Glu Arg Met Phe Leu Ser Phe Pro Thr Thr Lys

20 25

<210> 4767

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4767

Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala Lys Asn

1 5 10 15

Gln Leu Thr

<210> 4768

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4768

Ala Gly Leu Leu Ser Thr Tyr Arg Ala Phe Leu Ser Ser His

1 5 10

<210> 4769

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4769

Ala Gly Asn Leu Gly Gly Gly Val Val Thr Ile Glu Arg Ser Lys

1 5 10 15

<210> 4770

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4770

Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr Met Leu Ala

1 5 10 15

<210> 4771

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4771

Ala His Leu Leu Ile Leu Arg Asp Thr Lys Thr Tyr Met Leu Ala Phe

1 5 10 15

<210> 4772

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4772

Ala Lys Ala Val Lys Gln Phe Glu Glu Ser Gln Gly Arg

1 5 10

<210> 4773

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4773

Ala Lys Ala Val Lys Gln Phe Glu Glu Ser Gln Gly Arg Thr Ser Ser

1 5 10 15

Lys

<210> 4774

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4774

Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg

1 5 10

<210> 4775

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4775

Ala Lys Val Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln Pro Leu

1 5 10 15

Ser Leu

<210> 4776

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4776

Ala Ser Gly Asn Tyr Ala Thr Val Ile Ser His Asn Pro Glu Thr Lys

1 5 10 15

<210> 4777

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4777

Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg

1 5 10

<210> 4778

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4778

Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg Ser Gln Tyr Asn Phe

1 5 10 15

<210> 4779

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4779

Ala Val Pro Ser Pro Pro Pro Ala Ser Pro Arg Ser Gln Tyr Asn Phe

1 5 10 15

Ile Ala Asp

<210> 4780

<211> 24

<212>PRT

<213> Homo sapiens

<400> 4780

Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln

1 5 10 15

Lys Asp Leu Leu Glu Gln Lys Arg

20

<210> 4781

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4781

Ala Tyr Val Arg Leu Ala Pro Asp Tyr Asp Ala Leu Asp Val Ala Asn

1 5 10 15

Lys

<210> 4782

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4782

Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro Ala Ser Thr Gly Ala

1 5 10 15

Ala Lys

<210> 4783

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4783

Asp Gly Val Ile Lys Val Phe Asn Asp Met Lys Val Arg

1 5 10

<210> 4784

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4784

Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala

1 5 10 15

<210> 4785

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4785

Asp Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg

1 5 10 15

<210> 4786

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4786

Asp Pro Ser Pro Ser Pro Val Leu Gly Tyr Lys Ile Val Tyr Lys Pro

1 5 10 15

Val Gly

<210> 4787

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4787

Asp Arg Val Tyr Ile His Pro Phe His Leu

1 5 10

<210> 4788

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4788

Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe

1 5 10

<210> 4789

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4789

Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His

1 5 10 15

<210> 4790

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4790

Glu Asp Phe Arg Asp Gly Leu Lys Leu Met Leu Leu

1 5 10

<210> 4791

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4791

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn

1 5 10

<210> 4792

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4792

Glu Gly Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys

1 5 10 15

<210> 4793

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4793

Glu Ile Thr Ala Leu Ala Pro Ser Thr Met Lys

1 5 10

<210> 4794

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4794

Glu Gln Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His

1 5 10 15

<210> 4795

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4795

Phe Asp Pro Ile Ile Glu Asp Arg His Gly Gly Tyr Lys Pro

1 5 10

<210> 4796

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4796

Phe Asp Pro Ile Ile Glu Asp Arg His Gly Gly Tyr Lys Pro Ser

1 5 10 15

<210> 4797

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4797

Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val

1 5 10

<210> 4798

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4798

Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met Gly Asn

1 5 10 15

Pro Lys

<210> 4799

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4799

Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met Gly Asn

1 5 10 15

Pro Lys Val Lys

20

<210> 4800

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4800

Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg

1 5 10

<210> 4801

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4801

Phe Leu Glu Asn Val Ile Arg Asp Ala Val

1 5 10

<210> 4802

<211> 24

<212>PRT

<213> Homo sapiens

<400> 4802

Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu

1 5 10 15

Ser His Gly Ser Ala Gln Val Lys

20

<210> 4803

<211> 28

<212>PRT

<213> Homo sapiens

<400> 4803

Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu

1 5 10 15

Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys

20 25

<210> 4804

<211> 29

<212>PRT

<213> Homo sapiens

<400> 4804

Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp Leu

1 5 10 15

Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys

20 25

<210> 4805

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4805

Gly Ala Pro Ala Ala Ala Thr Ala Pro Ala Pro Thr Ala His Lys

1 5 10 15

<210> 4806

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4806

Gly Glu Leu Glu Lys Glu Glu Ala Gln Pro Ile Val Thr Lys Tyr

1 5 10 15

<210> 4807

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4807

Gly Gly Glu Leu Arg Phe Thr Val Thr Gln Arg Ser Gln Pro Gly

1 5 10 15

<210> 4808

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4808

Gly Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile Ile Thr

1 5 10 15

<210> 4809

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4809

Gly Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu

1 5 10

<210> 4810

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4810

Gly Leu Thr Phe Gln Met Lys Lys Asn Ala Glu Glu Leu Lys

1 5 10

<210> 4811

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4811

Gly Asn Arg Ile Ala Gln Trp Gln Ser Phe Gln Leu Glu Gly Gly

1 5 10 15

<210> 4812

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4812

Gly Arg Met His Ala Pro Gly Lys Gly Leu Ser Gln Ser Ala Leu Pro

1 5 10 15

Tyr Arg

<210> 4813

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4813

Gly Thr Leu Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly

1 5 10

<210> 4814

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4814

Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp

1 5 10 15

Thr

<210> 4815

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4815

Ile Gly Ser Ser Gln Asp Asp Gly Leu Ile Asn Arg

1 5 10

<210> 4816

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4816

Ile Gly Ser Ser Tyr Phe Pro Glu His Gly Tyr Phe Arg Ala Pro Glu

1 5 10 15

<210> 4817

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4817

Ile Lys Glu Glu Ser Lys Thr Ala Val

15

<210> 4818

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4818

Ile Pro Asp Trp Phe Leu Asn Arg

15

<210> 4819

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4819

Ile Arg Ala Ser Tyr Ala Gln Gln Pro Ala Glu Ser Arg Val Ser Gly

1 5 10 15

<210> 4820

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4820

Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser Asn Arg

1 5 10

<210> 4821

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4821

Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp Gly Phe Leu

1 5 10 15

Ser Glu

<210> 4822

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4822

Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp Gly Phe Leu

1 5 10 15

Ser Glu Leu Thr Gln Gln

20

<210> 4823

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4823

Ile Tyr Thr Arg Asn Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu

1 5 10 15

Asp Ala

<210> 4824

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4824

Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala

1 5 10

<210> 4825

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4825

Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly

1 5 10 15

<210> 4826

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4826

Lys Glu Tyr Phe Ala Ile Asp Asn Ser Gly Arg Ile Ile Thr

1 5 10

<210> 4827

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4827

Lys Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg

1 5 10 15

<210> 4828

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4828

Lys Pro Gly Gln Phe Ile Arg Ser Val Asp Pro Asp Ser Pro Ala

1 5 10 15

<210> 4829

<211> 26

<212>PRT

<213> Homo sapiens

<400> 4829

Lys Thr Asn Val Lys Ala Ala Trp Gly Lys Val Gly Ala His Ala Gly

1 5 10 15

Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met

20 25

<210> 4830

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4830

Leu Ala Gln Ala Thr Gly Lys Pro Pro Gln Tyr Ile Ala Val His Val

1 5 10 15

Val Pro Asp Gln Leu

20

<210> 4831

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4831

Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser Asn Arg

1 5 10

<210> 4832

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4832

Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys

1 5 10

<210> 4833

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4833

Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro

1 5 10

<210> 4834

<211> 19

<212>PRT

<213> Homo sapiens

<400> 4834

Leu Leu Thr Glu Ala Pro Leu Asn Pro Lys Ala Asn Arg Glu Lys Met

1 5 10 15

Thr Gln Ile

<210> 4835

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4835

Leu Leu Val Val Tyr Pro Trp Thr Gln Arg

1 5 10

<210> 4836

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4836

Leu Leu Val Val Tyr Pro Trp Thr Gln Arg Phe

1 5 10

<210> 4837

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4837

Leu Arg Val Asp Pro Val Asn Phe Lys

15

<210> 4838

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4838

Leu Ser Leu Gln Glu Pro Gly Ser Lys Thr

1 5 10

<210> 4839

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4839

Leu Val Thr Leu Ala Ala His Leu Pro Ala Glu Phe Thr Pro Ala Val

1 5 10 15

His Ala Ser Leu Asp Lys

20

<210> 4840

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4840

Asn Ile Phe Ser Phe Tyr Leu Ser Arg Asp Pro Asp Ala Gln Pro Gly

1 5 10 15

<210> 4841

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4841

Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp

1 5 10 15

Gly Phe Leu Ser Glu

20

<210> 4842

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4842

Gln Leu Gln Pro Asp Asn Ser Thr Leu Thr Trp Val Lys Pro Thr

1 5 10 15

<210> 4843

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4843

Gln Val Asp Gln Phe Leu Gly Val Pro Tyr Ala Ala Pro Pro Leu Ala

1 5 10 15

Glu Arg

<210> 4844

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4844

Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe Lys Thr Pro Arg Gly

1 5 10 15

Pro Val

<210> 4845

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4845

Arg Glu Ile Phe Asn Met Ala Arg Asp Gln Arg Ser Arg

1 5 10

<210> 4846

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4846

Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val

1 5 10

<210> 4847

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4847

Arg Gly Asn Ser Ile Ile Met Leu Glu Ala Leu Glu Arg Val

1 5 10

<210> 4848

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4848

Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val

1 5 10

<210> 4849

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4849

Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val Ser Glu Gly

1 5 10 15

Thr Lys

<210> 4850

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4850

Arg Leu Pro Ile Ile Asp Val Ala Pro Leu Asp Val Gly Ala Pro Asp

1 5 10 15

<210> 4851

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4851

Arg Pro Lys Asp Tyr Glu Val Asp Ala Thr Leu Lys Ser Leu Asn Asn

1 5 10 15

<210> 4852

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4852

Arg Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr

1 5 10 15

<210> 4853

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4853

Arg Tyr Ser Val Asp Ile Pro Leu Asp Lys Thr Val Val

1 5 10

<210> 4854

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4854

Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Ala Glu Lys

1 5 10 15

Ala Pro Val Lys Lys

20

<210> 4855

<211> 22

<212>PRT

<213> Homo sapiens

<400> 4855

Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Ala Glu Lys

1 5 10 15

Ala Pro Val Lys Lys Lys

20

<210> 4856

<211> 33

<212>PRT

<213> Homo sapiens

<400> 4856

Ser Gly Asn Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly

1 5 10 15

Gly Asn Tyr Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly

20 25 30

Arg

<210> 4857

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4857

Ser Arg Ala Gly Leu Glu Leu Gly Ala Glu Pro Glu Thr Ile

1 5 10

<210> 4858

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4858

Ser Arg Thr Ser Gly Leu Leu Ser Ser Trp Lys

1 5 10

<210> 4859

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4859

Ser Val Pro Arg Tyr Leu Pro Arg Pro Ala Asn Pro Asp Glu

1 5 10

<210> 4860

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4860

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala

1 5 10 15

<210> 4861

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4861

Ser Trp Tyr Asp Asn Glu Phe Gly Tyr Ser Asn Arg Val Val

1 5 10

<210> 4862

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4862

Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg

1 5 10 15

Phe Arg

<210> 4863

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4863

Thr Gly Ala Ala Pro Ile Ile Asp Val Val Arg Ser Gly Tyr Tyr Lys

1 5 10 15

<210> 4864

<211> 23

<212>PRT

<213> Homo sapiens

<400> 4864

Thr Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val

1 5 10 15

Gly Gln Gly Ala Ser Ala Val

20

<210> 4865

<211> 13

<212>PRT

<213> Homo sapiens

<400> 4865

Thr Gly Lys Asn Lys Trp Phe Phe Gln Lys Leu Arg Phe

1 5 10

<210> 4866

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4866

Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val

1 5 10 15

<210> 4867

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4867

Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu Asp Arg

1 5 10

<210> 4868

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4868

Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr

1 5 10 15

<210> 4869

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4869

Thr Val Asp Gly Pro Ser Gly Lys Leu Trp Arg

1 5 10

<210> 4870

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4870

Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr

1 5 10 15

Val

<210> 4871

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4871

Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val Lys

1 5 10 15

<210> 4872

<211> 21

<212>PRT

<213> Homo sapiens

<400> 4872

Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val Lys

1 5 10 15

Gly His Gly Lys Lys

20

<210> 4873

<211> 29

<212>PRT

<213> Homo sapiens

<400> 4873

Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro

1 5 10 15

Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys

20 25

<210> 4874

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4874

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg

1 5 10 15

<210> 4875

<211> 24

<212>PRT

<213> Homo sapiens

<400> 4875

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met

1 5 10 15

Phe Leu Ser Phe Pro Thr Thr Lys

20

<210> 4876

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4876

Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala

1 5 10 15

Gly

<210> 4877

<211> 8

<212>PRT

<213> Homo sapiens

<400> 4877

Val His Leu Thr Pro Glu Glu Lys

15

<210> 4878

<211> 32

<212>PRT

<213> Homo sapiens

<400> 4878

Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly

1 5 10 15

Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu

20 25 30

<210> 4879

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4879

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys

1 5 10 15

<210> 4880

<211> 32

<212>PRT

<213> Homo sapiens

<400> 4880

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys

1 5 10 15

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met

20 25 30

<210> 4881

<211> 33

<212>PRT

<213> Homo sapiens

<400> 4881

Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly Lys

1 5 10 15

Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg Met

20 25 30

Phe

<210> 4882

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4882

Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu

1 5 10

<210> 4883

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4883

Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala

1 5 10

<210> 4884

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4884

Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr Val

1 5 10 15

<210> 4885

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4885

Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala

1 5 10

<210> 4886

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4886

Tyr Asp His Asn Phe Val Lys Ala Ile Asn Ala Ile Gln Lys

1 5 10

<210> 4887

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4887

Tyr Gly Gly Glu Leu Arg Phe Thr Val Thr Gln Arg Ser Gln Pro Gly

1 5 10 15

<210> 4888

<211> 16

<212>PRT

<213> Homo sapiens

<400> 4888

Tyr Pro Lys Ser Leu His Met Tyr Ala Asn Arg Leu Leu Asp His Arg

1 5 10 15

<210> 4889

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4889

Tyr Tyr Lys Val Asp Glu Asn Gly Lys Ile Ser Arg

1 5 10

<210> 4890

<211> 23

<212>PRT

<213> Homo sapiens

<400> 4890

Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln

1 5 10 15

Lys Asp Ile Leu Glu Gln Lys

20

<210> 4891

<211> 18

<212>PRT

<213> Homo sapiens

<400> 4891

Cys Pro Thr Pro Cys Gln Leu Gln Ala Glu Gln Ala Phe Leu Arg Thr

1 5 10 15

Val Gln

<210> 4892

<211> 17

<212>PRT

<213> Homo sapiens

<400> 4892

Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro Asp Gly Phe

1 5 10 15

Leu

<210> 4893

<211> 11

<212>PRT

<213> Homo sapiens

<400> 4893

Leu Leu Ile Pro Thr Ser Phe Ser Pro Leu Lys

1 5 10

<210> 4894

<211> 20

<212>PRT

<213> Homo sapiens

<400> 4894

Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Glu Lys Thr Pro Val Lys

1 5 10 15

Lys Lys Ala Arg

20

<210> 4895

<211> 764

<212>PRT

<213> Homo sapiens

<400> 4895

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro

1 5 10 15

Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His

20 25 30

Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro

35 40 45

Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu

50 55 60

Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg

65 70 75 80

Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser

85 90 95

Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg

100 105 110

Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu

115 120 125

Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu

130 135 140

Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp

145 150 155 160

Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys

165 170 175

Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val

180 185 190

Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn

195 200 205

Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val

210 215 220

Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala

225 230 235 240

Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn

245 250 255

Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu

260 265 270

Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn

275 280 285

Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser

290 295 300

Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser

305 310 315 320

Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly

325 330 335

Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr

340 345 350

Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln

355 360 365

Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His

370 375 380

Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro

385 390 395 400

Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe

405 410 415

Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn

420 425 430

Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val

435 440 445

Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly

450 455 460

Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu

465 470 475 480

Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr

485 490 495

Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu

500 505 510

Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg

515 520 525

Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly

530 535 540

Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile

545 550 555 560

Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr

565 570 575

Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val

580 585 590

Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val

595 600 605

Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys

610 615 620

Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile

625 630 635 640

Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val

645 650 655

Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys

660 665 670

Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp

675 680 685

Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln

690 695 700

Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln

705 710 715 720

Val Gln Lys Val Thr His Asp Met Arg Gln Gly Leu His Asn Met Glu

725 730 735

Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln

740 745 750

Gly Gln Ile Ser Glu Glu Tyr Met Gln Thr Val Leu

755 760

<210> 4896

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4896

Ala Leu Ala Val Leu Ser Val Thr Leu

15

<210> 4897

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4897

Ala Leu Ser Glu Asp Leu Leu Ser Ile

15

<210> 4898

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4898

Gly Leu Leu Asp Gln Val Ala Ala Leu

15

<210> 4899

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4899

Gly Leu Arg Glu Asp Leu Leu Ser Leu

15

<210> 4900

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4900

Leu Leu Ile Gly Gly Phe Ala Gly Leu

15

<210> 4901

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4901

Ser Leu Gln Asp Val Pro Leu Ala Ala Leu

1 5 10

<210> 4902

<211> 9

<212>PRT

<213> Streptococcus pyogenes

<400> 4902

Ala Leu Glu Lys Leu Asn Lys Glu Leu

15

<210> 4903

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4903

Glu Phe Gln Lys Met Arg Arg Asp Leu

15

<210> 4904

<211> 9

<212>PRT

<213> Streptococcus pyogenes

<400> 4904

Lys Leu Asn Lys Glu Leu Glu Glu Ser

15

<210> 4905

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4905

Lys Met Arg Arg Asp Leu Glu Glu Ala

15

<210> 4906

<211> 43

<212>PRT

<213> Homo sapiens

<400> 4906

Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu Arg

1 5 10 15

Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu Glu

20 25 30

Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln

35 40

<210> 4907

<211> 25

<212>PRT

<213> Homo sapiens

<400> 4907

Val Ala Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg

1 5 10 15

Gly Arg Gly Arg Gly Gly Pro Arg Arg

20 25

<210> 4908

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4908

Gly Ser Ala Ser Pro Met Glu Leu Leu Ser

1 5 10

<210> 4909

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4909

Ile Phe Met Ser Asn Ser Tyr Pro Arg Asp

1 5 10

<210> 4910

<211> 12

<212>PRT

<213> Homo sapiens

<400> 4910

Arg Leu Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn

1 5 10

<210> 4911

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4911

Ser Ala Arg Ile Pro Cys Phe Leu Ala Gly

1 5 10

<210> 4912

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4912

Trp Asp Gly Glu Arg Leu Tyr Gln Glu Ala

1 5 10

<210> 4913

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4913

Trp Thr Pro Gly Val Lys Arg Asn Gly Phe

1 5 10

<210> 4914

<211> 10

<212>PRT

<213> Homo sapiens

<400> 4914

Tyr Arg Ser Tyr Asn Asp Ser Val Asp Pro

1 5 10

<210> 4915

<211> 7

<212>PRT

<213> Helicobacter pylori

<400> 4915

Ala Lys Glu Glu Arg Arg Tyr

15

<210> 4916

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with autoimmune pancreatitis

<400> 4916

Arg Phe Glu Gln Pro Arg Val

15

<210> 4917

<211> 7

<212>PRT

<213> Unknown

<220>

<223> epitope associated with autoimmune pancreatitis

<400> 4917

Ser Lys Asp Glu Arg Arg Phe

15

<210> 4918

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4918

Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp Lys Glu Asn Arg

1 5 10 15

<210> 4919

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4919

Gly Glu Ala Leu Ser Thr Leu Val Leu Asn Arg Leu Lys Val Gly

1 5 10 15

<210> 4920

<211> 15

<212>PRT

<213> Mycobacterium species

<400> 4920

Gly Glu Ala Leu Ser Thr Leu Val Val Asn Lys Ile Arg Gly Thr

1 5 10 15

<210> 4921

<211> 15

<212>PRT

<213> Mycobacterium species

<400> 4921

Ile Ala Gly Leu Phe Leu Thr Thr Glu Ala Val Val Ala Asp Lys

1 5 10 15

<210> 4922

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4922

Val Ala Ser Leu Leu Thr Thr Ala Glu Val Val Val Thr Glu Ile

1 5 10 15

<210> 4923

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4923

Gly Gly Ile Tyr Gln Asp Leu Val Ser

15

<210> 4924

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4924

Gly Leu Leu Ala Gln Gln Met Asp Tyr

15

<210> 4925

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4925

Arg Leu Val Gly Gln Gln Val Met Gln

15

<210> 4926

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4926

Arg Gln Ser Asp Gly Gln Tyr Gln Met

15

<210> 4927

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4927

Tyr Arg Trp Leu Pro Pro Ser Ser Ala

15

<210> 4928

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4928

Ala Gly Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr

1 5 10 15

<210> 4929

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4929

Cys Gln Ala Leu Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys

1 5 10 15

<210> 4930

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4930

Asp Phe Thr Tyr Asp Gln Val Ala Phe Asn Gly Leu Pro Gln Phe

1 5 10 15

<210> 4931

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4931

Asp Lys Ile Arg Gly Glu Gly Met Arg Tyr Ile Ile Ile Leu Asp

1 5 10 15

<210> 4932

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4932

Glu Arg Pro Leu Lys Gln Ile Ala Phe Asn Gly Gly Leu Glu Pro

1 5 10 15

<210> 4933

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4933

Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp Gly

1 5 10 15

<210> 4934

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4934

Leu Ala Lys Leu Ala Gly Gly Val Ala Val Ile Cys Ala Gly Ala

1 5 10 15

<210> 4935

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4935

Leu Ala Lys Leu Gly Gly Ala Gly Gln Ala Ala Arg Ala Gly Thr

1 5 10 15

<210> 4936

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4936

Asn Glu His Pro Val Phe Ala Tyr Leu Lys Asp Lys Leu Pro

1 5 10

<210> 4937

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4937

Gln Leu Glu Leu Thr Glu Gly Met Arg Phe Asp Lys Gly Tyr Ile

1 5 10 15

<210> 4938

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4938

Cys Asn Leu Trp Glu Val Met His Gly Thr Cys

1 5 10

<210> 4939

<211> 11

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4939

Cys Ser Ile Gly Glu Ala Leu Ser His Gly Cys

1 5 10

<210> 4940

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4940

Pro Trp Ala Thr Leu Val Ala Glu Ser

15

<210> 4941

<211> 9

<212>PRT

<213> Unknown

<220>

<223> epitope associated with Crohn's disease

<400> 4941

Thr Met Trp Asp Ala Leu Glu Ala Pro

15

<210> 4942

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4942

Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp Lys Glu Asn Arg

1 5 10 15

<210> 4943

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4943

Pro Lys Lys Ala Lys

15

<210> 4944

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4944

Ala Gly Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr

1 5 10 15

<210> 4945

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4945

Cys Gln Ala Leu Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys

1 5 10 15

<210> 4946

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4946

Asp Phe Thr Tyr Asp Gln Val Ala Phe Asn Gly Leu Pro Gln Phe

1 5 10 15

<210> 4947

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4947

Asp Lys Ile Arg Gly Glu Gly Met Arg Tyr Ile Ile Ile Leu Asp

1 5 10 15

<210> 4948

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4948

Glu Arg Pro Leu Lys Gln Ile Ala Phe Asn Gly Gly Leu Glu Pro

1 5 10 15

<210> 4949

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4949

Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp Gly

1 5 10 15

<210> 4950

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4950

Asn Glu His Pro Val Phe Ala Tyr Leu Lys Asp Lys Leu Pro

1 5 10

<210> 4951

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4951

Gln Leu Glu Leu Thr Glu Gly Met Arg Phe Asp Lys Gly Tyr Ile

1 5 10 15

<210> 4952

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4952

Ala His Trp Ser Gly His Cys Cys Leu

15

<210> 4953

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4953

Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp Lys Glu Asn Arg

1 5 10 15

<210> 4954

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4954

Pro Lys Lys Ala Lys

15

<210> 4955

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4955

Ala Gly Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr

1 5 10 15

<210> 4956

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4956

Cys Gln Ala Leu Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys

1 5 10 15

<210> 4957

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4957

Asp Phe Thr Tyr Asp Gln Val Ala Phe Asn Gly Leu Pro Gln Phe

1 5 10 15

<210> 4958

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4958

Asp Lys Ile Arg Gly Glu Gly Met Arg Tyr Ile Ile Ile Leu Asp

1 5 10 15

<210> 4959

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4959

Glu Arg Pro Leu Lys Gln Ile Ala Phe Asn Gly Gly Leu Glu Pro

1 5 10 15

<210> 4960

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4960

Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp Gly

1 5 10 15

<210> 4961

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4961

Asn Glu His Pro Val Phe Ala Tyr Leu Lys Asp Lys Leu Pro

1 5 10

<210> 4962

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4962

Gln Leu Glu Leu Thr Glu Gly Met Arg Phe Asp Lys Gly Tyr Ile

1 5 10 15

<210> 4963

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4963

Ala His Trp Ser Gly His Cys Cys Leu

15

<210> 4964

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4964

Thr Cys Arg Arg Met Leu Ala Phe Leu Lys Asp Lys Glu Asn Arg

1 5 10 15

<210> 4965

<211> 5

<212>PRT

<213> Homo sapiens

<400> 4965

Pro Lys Lys Ala Lys

15

<210> 4966

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4966

Ala Gly Asp Leu Ser Lys Val Asp Ala Lys Gln Pro Gly Asp Tyr

1 5 10 15

<210> 4967

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4967

Cys Gln Ala Leu Val Arg Met Leu Ala Lys Lys Pro Gly Trp Lys

1 5 10 15

<210> 4968

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4968

Asp Phe Thr Tyr Asp Gln Val Ala Phe Asn Gly Leu Pro Gln Phe

1 5 10 15

<210> 4969

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4969

Asp Lys Ile Arg Gly Glu Gly Met Arg Tyr Ile Ile Ile Leu Asp

1 5 10 15

<210> 4970

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4970

Glu Arg Pro Leu Lys Gln Ile Ala Phe Asn Gly Gly Leu Glu Pro

1 5 10 15

<210> 4971

<211> 15

<212>PRT

<213> Homo sapiens

<400> 4971

Gly Arg Gly Asn Gly Asp Pro Gly Gly Gly Met Glu Lys Asp Gly

1 5 10 15

<210> 4972

<211> 14

<212>PRT

<213> Homo sapiens

<400> 4972

Asn Glu His Pro Val Phe Ala Tyr Leu Lys Asp Lys Leu Pro

1 5 10

<210> 4973

<211> 15

<212>PRT

<213> Mycobacterium avium

<400> 4973

Gln Leu Glu Leu Thr Glu Gly Met Arg Phe Asp Lys Gly Tyr Ile

1 5 10 15

<210> 4974

<211> 9

<212>PRT

<213> Homo sapiens

<400> 4974

Ala His Trp Ser Gly His Cys Cys Leu

15

<210> 4975

<211> 304

<212>PRT

<213> Homo sapiens

<400> 4975

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser

1 5 10 15

Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu

20 25 30

Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu

35 40 45

Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val

50 55 60

Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala

65 70 75 80

His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser

85 90 95

Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser

100 105 110

Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser

115 120 125

Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His

130 135 140

Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His

145 150 155 160

Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly

165 170 175

Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys

180 185 190

Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln

195 200 205

Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe

210 215 220

Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly

225 230 235 240

Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg

245 250 255

Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His

260 265 270

Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe

275 280 285

Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg

290 295 300

<210> 4976

<211> 203

<212>PRT

<213> Homo sapiens

<400> 4976

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu

1 5 10 15

Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg

20 25 30

His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly

35 40 45

Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys

50 55 60

Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu

65 70 75 80

Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr

85 90 95

Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro

100 105 110

Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro

115 120 125

Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly

130 135 140

Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp

145 150 155 160

Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr

165 170 175

Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser

180 185 190

Pro Met Ala Arg Arg His His His His His

195 200

<210> 4977

<211> 277

<212>PRT

<213> Homo sapiens

<400> 4977

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe

1 5 10 15

Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe

20 25 30

Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu

35 40 45

Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val

50 55 60

Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe

65 70 75 80

Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala

85 90 95

Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly

100 105 110

Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly

115 120 125

Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys

130 135 140

Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr

145 150 155 160

Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile

165 170 175

Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys

180 185 190

Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly

195 200 205

Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu

210 215 220

Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe

225 230 235 240

Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr

245 250 255

Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly

260 265 270

Arg Gly Thr Lys Phe

275

<210> 4978

<211> 295

<212>PRT

<213> Homo sapiens

<400> 4978

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe

1 5 10 15

Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe

20 25 30

Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu

35 40 45

Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met

50 55 60

Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr

65 70 75 80

Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly

85 90 95

Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu

100 105 110

Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe

115 120 125

Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val

130 135 140

Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala

145 150 155 160

Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu

165 170 175

Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn

180 185 190

Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys

195 200 205

Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu

210 215 220

Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu

225 230 235 240

Glu Glu Leu Arg Lys Phe Ser Ser Leu Cys Tyr Lys Gln Arg Ile Lys

245 250 255

Ser Gln Glu Arg Glu Thr Glu Ala Thr Arg Gly Arg Gly Gly Leu Leu

260 265 270

Arg Asp His Ile Pro Arg Gly Lys Glu Glu Leu Glu Ser Leu Gly Gly

275 280 285

Gly Lys Thr Pro Pro Gly Arg

290 295

<210> 4979

<211> 323

<212>PRT

<213> Homo sapiens

<400> 4979

Met Ser Asp Arg Pro Thr Ala Arg Arg Trp Gly Lys Cys Gly Pro Leu

1 5 10 15

Cys Thr Arg Glu Asn Ile Met Val Ala Phe Lys Gly Val Trp Thr Gln

20 25 30

Ala Phe Trp Lys Ala Val Thr Ala Glu Phe Leu Ala Met Leu Ile Phe

35 40 45

Val Leu Leu Ser Leu Gly Ser Thr Ile Asn Trp Gly Gly Thr Glu Lys

50 55 60

Pro Leu Pro Val Asp Met Val Leu Ile Ser Leu Cys Phe Gly Leu Ser

65 70 75 80

Ile Ala Thr Met Val Gln Cys Phe Gly His Ile Ser Gly Gly His Ile

85 90 95

Asn Pro Ala Val Thr Val Ala Met Val Cys Thr Arg Lys Ile Ser Ile

100 105 110

Ala Lys Ser Val Phe Tyr Ile Ala Ala Gln Cys Leu Gly Ala Ile Ile

115 120 125

Gly Ala Gly Ile Leu Tyr Leu Val Thr Pro Pro Ser Val Val Gly Gly

130 135 140

Leu Gly Val Thr Met Val His Gly Asn Leu Thr Ala Gly His Gly Leu

145 150 155 160

Leu Val Glu Leu Ile Ile Thr Phe Gln Leu Val Phe Thr Ile Phe Ala

165 170 175

Ser Cys Asp Ser Lys Arg Thr Asp Val Thr Gly Ser Ile Ala Leu Ala

180 185 190

Ile Gly Phe Ser Val Ala Ile Gly His Leu Phe Ala Ile Asn Tyr Thr

195 200 205

Gly Ala Ser Met Asn Pro Ala Arg Ser Phe Gly Pro Ala Val Ile Met

210 215 220

Gly Asn Trp Glu Asn His Trp Ile Tyr Trp Val Gly Pro Ile Ile Gly

225 230 235 240

Ala Val Leu Ala Gly Gly Leu Tyr Glu Tyr Val Phe Cys Pro Asp Val

245 250 255

Glu Phe Lys Arg Arg Phe Lys Glu Ala Phe Ser Lys Ala Ala Gln Gln

260 265 270

Thr Lys Gly Ser Tyr Met Glu Val Glu Asp Asn Arg Ser Gln Val Glu

275 280 285

Thr Asp Asp Leu Ile Leu Lys Pro Gly Val Val His Val Ile Asp Val

290 295 300

Asp Arg Gly Glu Glu Lys Lys Gly Lys Asp Gln Ser Gly Glu Val Leu

305 310 315 320

Ser Ser Val

<210> 4980

<211> 582

<212>PRT

<213> Homo sapiens

<400> 4980

Met Ile Phe Leu Thr Ala Leu Pro Leu Phe Trp Ile Met Ile Ser Ala

1 5 10 15

Ser Arg Gly Gly His Trp Gly Ala Trp Met Pro Ser Ser Ile Ser Ala

20 25 30

Phe Glu Gly Thr Cys Val Ser Ile Pro Cys Arg Phe Asp Phe Pro Asp

35 40 45

Glu Leu Arg Pro Ala Val Val His Gly Val Trp Tyr Phe Asn Ser Pro

50 55 60

Tyr Pro Lys Asn Tyr Pro Pro Val Val Phe Lys Ser Arg Thr Gln Val

65 70 75 80

Val His Glu Ser Phe Gln Gly Arg Ser Arg Leu Leu Gly Asp Leu Gly

85 90 95

Leu Arg Asn Cys Thr Leu Leu Leu Ser Asn Val Ser Pro Glu Leu Gly

100 105 110

Gly Lys Tyr Tyr Phe Arg Gly Asp Leu Gly Gly Tyr Asn Gln Tyr Thr

115 120 125

Phe Ser Glu His Ser Val Leu Asp Ile Val Asn Thr Pro Asn Ile Val

130 135 140

Val Pro Pro Glu Val Val Ala Gly Thr Glu Val Glu Val Ser Cys Met

145 150 155 160

Val Pro Asp Asn Cys Pro Glu Leu Arg Pro Glu Leu Ser Trp Leu Gly

165 170 175

His Glu Gly Leu Gly Glu Pro Ala Val Leu Gly Arg Leu Arg Glu Asp

180 185 190

Glu Gly Thr Trp Val Gln Val Ser Leu Leu His Phe Val Pro Thr Arg

195 200 205

Glu Ala Asn Gly His Arg Leu Gly Cys Gln Ala Ser Phe Pro Asn Thr

210 215 220

Thr Leu Gln Phe Glu Gly Tyr Ala Ser Met Asp Val Lys Tyr Pro Pro

225 230 235 240

Val Ile Val Glu Met Asn Ser Ser Val Glu Ala Ile Glu Gly Ser His

245 250 255

Val Ser Leu Leu Cys Gly Ala Asp Ser Asn Pro Pro Pro Leu Leu Thr

260 265 270

Trp Met Arg Asp Gly Thr Val Leu Arg Glu Ala Val Ala Glu Ser Leu

275 280 285

Leu Leu Glu Leu Glu Glu Val Thr Pro Ala Glu Asp Gly Val Tyr Ala

290 295 300

Cys Leu Ala Glu Asn Ala Tyr Gly Gln Asp Asn Arg Thr Val Gly Leu

305 310 315 320

Ser Val Met Tyr Ala Pro Trp Lys Pro Thr Val Asn Gly Thr Met Val

325 330 335

Ala Val Glu Gly Glu Thr Val Ser Ile Leu Cys Ser Thr Gln Ser Asn

340 345 350

Pro Asp Pro Ile Leu Thr Ile Phe Lys Glu Lys Gln Ile Leu Ser Thr

355 360 365

Val Ile Tyr Glu Ser Glu Leu Gln Leu Glu Leu Pro Ala Val Ser Pro

370 375 380

Glu Asp Asp Gly Glu Tyr Trp Cys Val Ala Glu Asn Gln Tyr Gly Gln

385 390 395 400

Arg Ala Thr Ala Phe Asn Leu Ser Val Glu Phe Ala Pro Val Leu Leu

405 410 415

Leu Glu Ser His Cys Ala Ala Ala Arg Asp Thr Val Gln Cys Leu Cys

420 425 430

Val Val Lys Ser Asn Pro Glu Pro Ser Val Ala Phe Glu Leu Pro Ser

435 440 445

Arg Asn Val Thr Val Asn Glu Ser Glu Arg Glu Phe Val Tyr Ser Glu

450 455 460

Arg Ser Gly Leu Val Leu Thr Ser Ile Leu Thr Leu Arg Gly Gln Ala

465 470 475 480

Gln Ala Pro Pro Arg Val Ile Cys Thr Ala Arg Asn Leu Tyr Gly Ala

485 490 495

Lys Ser Leu Glu Leu Pro Phe Gln Gly Ala His Arg Leu Met Trp Ala

500 505 510

Lys Ile Gly Pro Val Gly Ala Val Val Ala Phe Ala Ile Leu Ile Ala

515 520 525

Ile Val Cys Tyr Ile Thr Gln Thr Arg Arg Lys Lys Asn Val Thr Glu

530 535 540

Ser Pro Ser Phe Ser Ala Gly Asp Asn Pro Pro Val Leu Phe Ser Ser

545 550 555 560

Asp Phe Arg Ile Ser Gly Ala Pro Glu Lys Tyr Glu Ser Lys Glu Val

565 570 575

Ser Thr Leu Glu Ser His

580

<210> 4981

<211> 110

<212>PRT

<213> Homo sapiens

<400> 4981

Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu

1 5 10 15

Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly

20 25 30

Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe

35 40 45

Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly

50 55 60

Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu

65 70 75 80

Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys

85 90 95

Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn

100 105 110

<210> 4982

<211> 180

<212>PRT

<213> Homo sapiens

<400> 4982

Ile Ala Pro Val Phe Val Leu Met Glu Gln Ile Thr Leu Lys Lys Met

1 5 10 15

Arg Lys Ile Val Gly Trp Ser Asn Lys Asp Gly Asp Gly Ile Phe Ser

20 25 30

Pro Gly Gly Ala Ile Ser Asn Met Tyr Ser Ile Met Ala Ala Arg Tyr

35 40 45

Lys Tyr Phe Pro Glu Val Lys Thr Lys Gly Met Ala Ala Val Pro Lys

50 55 60

Leu Val Leu Phe Thr Ser Glu His Ser His Tyr Ser Ile Lys Lys Ala

65 70 75 80

Gly Ala Ala Leu Gly Phe Gly Thr Asp Asn Val Ile Leu Ile Lys Cys

85 90 95

Asn Glu Arg Gly Lys Ile Ile Pro Ala Asp Leu Glu Ala Lys Ile Leu

100 105 110

Asp Ala Lys Gln Lys Gly Tyr Val Pro Leu Tyr Val Asn Ala Thr Ala

115 120 125

Gly Thr Thr Val Tyr Gly Ala Phe Asp Pro Ile Gln Glu Ile Ala Asp

130 135 140

Ile Cys Glu Lys Tyr Asn Leu Trp Leu His Val Asp Ala Ala Trp Gly

145 150 155 160

Gly Gly Leu Leu Met Ser Arg Lys His Arg His Lys Leu Ser Gly Ile

165 170 175

Glu Arg Ala Asn

180

<210> 4983

<211> 296

<212>PRT

<213> Triticum urartu

<400> 4983

Met Lys Thr Phe Leu Ile Leu Ala Leu Leu Ala Ile Val Ala Thr Thr

1 5 10 15

Ala Thr Thr Ala Val Arg Val Pro Val Pro Gln Pro Gln Pro Gln Asn

20 25 30

Pro Ser Gln Pro Gln Pro Gln Arg Gln Val Pro Leu Val Gln Gln Gln

35 40 45

Gln Phe Pro Gly Gln Gln Gln Gln Phe Pro Pro Gln Gln Pro Tyr Pro

50 55 60

Gln Pro Gln Pro Phe Pro Ser Gln Gln Pro Tyr Leu Gln Leu Gln Pro

65 70 75 80

Phe Pro Gln Pro Gln Pro Phe Pro Pro Gln Leu Pro Tyr Pro Gln Pro

85 90 95

Pro Pro Phe Ser Pro Gln Gln Pro Tyr Pro Gln Pro Gln Pro Gln Tyr

100 105 110

Pro Gln Pro Gln Gln Pro Ile Ser Gln Gln Gln Ala Gln Gln Gln Gln

115 120 125

Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ile Leu

130 135 140

Pro Gln Ile Leu Gln Gln Gln Leu Ile Pro Cys Arg Asp Val Val Leu

145 150 155 160

Gln Gln His Asn Ile Ala His Ala Arg Ser Gln Val Leu Gln Gln Ser

165 170 175

Thr Tyr Gln Pro Leu Gln Gln Leu Cys Cys Gln Gln Leu Trp Gln Ile

180 185 190

Pro Glu Gln Ser Arg Cys Gln Ala Ile His Asn Val Val His Ala Ile

195 200 205

Ile Leu His Gln Gln Gln Gln Gln Gln Gln Pro Ser Ser Gln Val Ser

210 215 220

Leu Gln Gln Pro Gln Gln Gln Tyr Pro Ser Gly Gln Gly Phe Phe Gln

225 230 235 240

Pro Ser Gln Gln Asn Pro Gln Ala Gln Gly Ser Val Gln Pro Gln Gln

245 250 255

Leu Pro Gln Phe Glu Glu Ile Arg Asn Leu Ala Leu Gln Thr Leu Pro

260 265 270

Arg Met Cys Asn Val Tyr Ile Pro Pro Tyr Cys Ser Thr Thr Thr Ala

275 280 285

Pro Phe Gly Ile Phe Gly Thr Asn

290 295

<210> 4984

<211> 275

<212>PRT

<213> Triticum durum

<400> 4984

Met Asn Ile Gln Val Asp Pro Ser Ser Gln Val Gln Trp Pro Gln Gln

1 5 10 15

Gln Pro Phe Leu Gln Pro His Gln Pro Phe Ser Gln Gln Pro Gln Gln

20 25 30

Ile Phe Pro Gln Pro Gln Gln Thr Phe Pro His Gln Pro Gln Gln Gln

35 40 45

Phe Pro Gln Pro Gln Gln Pro Gln Arg Gln Phe Leu Gln Pro Arg Gln

50 55 60

Pro Phe Pro Gln Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro Gln Gln

65 70 75 80

Pro Phe Pro Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Ser Lys

85 90 95

Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Gln Gln Ser Phe

100 105 110

Pro Gln Gln Gln Pro Ser Leu Ile Gln Gln Ser Leu Gln Gln Gln Leu

115 120 125

Asn Pro Cys Lys Asn Phe Leu Leu Gln Gln Cys Lys Pro Val Ser Leu

130 135 140

Val Ser Ser Leu Trp Ser Ile Ile Leu Pro Pro Ser Asp Cys Gln Val

145 150 155 160

Met Arg Gln Gln Cys Cys Gln Gln Leu Ala Gln Ile Pro Gln Gln Leu

165 170 175

Gln Cys Ala Ala Ile His Ser Val Val His Ser Ile Ile Met Gln Gln

180 185 190

Glu Gln Gln Glu Gln Leu Gln Gly Val Gln Ile Leu Val Pro Leu Ser

195 200 205

Gln Gln Gln Gln Val Gly Gln Gly Ile Leu Val Gln Gly Gln Gly Ile

210 215 220

Ile Gln Pro Gln Gln Pro Ala Gln Leu Glu Val Ile Arg Ser Leu Val

225 230 235 240

Leu Gln Thr Leu Pro Thr Met Cys Asn Val Tyr Val Pro Pro Tyr Cys

245 250 255

Ser Thr Ile Arg Ala Pro Phe Ala Ser Ile Val Ala Gly Ile Gly Gly

260 265 270

Gln Tyr Arg

275

<210> 4985

<211> 282

<212>PRT

<213> Triticum aestivum

<400> 4985

Met Asn Ile Gln Val Asp Pro Ser Ser Gln Val Pro Trp Pro Gln Gln

1 5 10 15

Gln Pro Phe Pro Gln Pro His Gln Pro Phe Ser Gln Gln Pro Gln Gln

20 25 30

Thr Phe Pro Gln Pro Gln Gln Thr Phe Pro His Gln Pro Gln Gln Gln

35 40 45

Phe Ser Gln Pro Gln Gln Pro Gln Gln Gln Phe Ile Gln Pro Gln Gln

50 55 60

Pro Phe Pro Gln Gln Pro Gln Gln Thr Tyr Pro Gln Arg Pro Gln Gln

65 70 75 80

Pro Phe Pro Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Ser Gln

85 90 95

Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Gln Phe Pro Gln Pro

100 105 110

Gln Gln Pro Gln Gln Ser Phe Pro Gln Gln Gln Pro Ser Leu Ile Gln

115 120 125

Gln Ser Leu Gln Gln Gln Leu Asn Pro Cys Lys Asn Phe Leu Leu Gln

130 135 140

Gln Cys Lys Pro Val Ser Leu Val Ser Ser Leu Trp Ser Met Ile Leu

145 150 155 160

Pro Arg Ser Asp Cys Gln Val Met Arg Gln Gln Cys Cys Gln Gln Leu

165 170 175

Ala Gln Ile Pro Gln Gln Leu Gln Cys Ala Ala Ile His Ser Ile Val

180 185 190

His Ser Ile Ile Met Gln Gln Glu Gln Gln Glu Gln Arg Gln Gly Val

195 200 205

Gln Ile Leu Val Pro Leu Ser Gln Gln Gln Gln Val Gly Gln Gly Thr

210 215 220

Leu Val Gln Gly Gln Gly Ile Ile Gln Pro Gln Gln Pro Ala Gln Leu

225 230 235 240

Glu Val Ile Arg Ser Leu Val Leu Gln Thr Leu Ala Thr Met Cys Asn

245 250 255

Val Tyr Val Pro Pro Tyr Cys Ser Thr Ile Arg Ala Pro Phe Ala Ser

260 265 270

Ile Val Ala Gly Ile Gly Gly Gln Tyr Arg

275 280

<210> 4986

<211> 9

<212>PRT

<213> Triticum species

<400> 4986

Pro Phe Pro Gln Pro Glu Leu Pro Tyr

15

<210> 4987

<211> 9

<212>PRT

<213> Triticum species

<400> 4987

Pro Tyr Pro Gln Pro Glu Leu Pro Tyr

15

<210> 4988

<211> 9

<212>PRT

<213> Triticum species

<400> 4988

Pro Gln Pro Glu Leu Pro Tyr Pro Trp

15

<210> 4989

<211> 10

<212>PRT

<213> Triticum species

<400> 4989

Phe Arg Pro Pro Glu Gln Pro Tyr Pro Gln

1 5 10

<210> 4990

<211> 9

<212>PRT

<213> Triticum species

<400> 4990

Pro Gln Gln Ser Phe Pro Glu Gln Gln

15

<210> 4991

<211> 9

<212>PRT

<213> Triticum species

<400> 4991

Ile Gln Pro Glu Gln Pro Ala Gln Leu

15

<210> 4992

<211> 9

<212>PRT

<213> Triticum species

<400> 4992

Gln Gln Pro Glu Gln Pro Tyr Pro Gln

15

<210> 4993

<211> 9

<212>PRT

<213> Triticum species

<400> 4993

Ser Gln Pro Glu Gln Glu Phe Pro Gln

15

<210> 4994

<211> 9

<212>PRT

<213> Triticum species

<400> 4994

Pro Gln Pro Glu Gln Glu Phe Pro Gln

15

<210> 4995

<211> 9

<212>PRT

<213> Triticum species

<400> 4995

Gln Gln Pro Glu Gln Pro Phe Pro Gln

15

<210> 4996

<211> 9

<212>PRT

<213> Triticum species

<400> 4996

Pro Gln Pro Glu Gln Pro Phe Cys Gln

15

<210> 4997

<211> 9

<212>PRT

<213> Triticum species

<400> 4997

Gln Gln Pro Phe Pro Glu Gln Pro Gln

15

<210> 4998

<211> 9

<212>PRT

<213> Triticum species

<400> 4998

Pro Phe Pro Gln Pro Glu Gln Pro Phe

15

<210> 4999

<211> 9

<212>PRT

<213> Triticum species

<400> 4999

Pro Gln Pro Glu Gln Pro Phe Pro Trp

15

<210> 5000

<211> 9

<212>PRT

<213> Triticum species

<400> 5000

Pro Phe Ser Glu Gln Glu Gln Pro Val

15

<210> 5001

<211> 9

<212>PRT

<213> Triticum species

<400> 5001

Phe Ser Gln Gln Gln Glu Ser Pro Phe

15

<210> 5002

<211> 9

<212>PRT

<213> Triticum species

<400> 5002

Pro Phe Pro Gln Pro Glu Gln Pro Phe

15

<210> 5003

<211> 9

<212>PRT

<213> Triticum species

<400> 5003

Pro Gln Pro Glu Gln Pro Phe Pro Gln

15

<210> 5004

<211> 9

<212>PRT

<213> Triticum species

<400> 5004

Pro Ile Pro Glu Gln Pro Gln Pro Tyr

15

<210> 5005

<211> 9

<212>PRT

<213> Triticum species

<400> 5005

Pro Phe Pro Gln Pro Glu Gln Pro Phe

15

<210> 5006

<211> 9

<212>PRT

<213> Triticum species

<400> 5006

Pro Gln Pro Glu Gln Pro Phe Pro Gln

15

<210> 5007

<211> 9

<212>PRT

<213> Triticum species

<400> 5007

Pro Tyr Pro Glu Gln Glu Glu Pro Phe

15

<210> 5008

<211> 9

<212>PRT

<213> Triticum species

<400> 5008

Pro Tyr Pro Glu Gln Glu Gln Pro Phe

15

<210> 5009

<211> 9

<212>PRT

<213> Triticum species

<400> 5009

Pro Phe Ser Glu Gln Glu Gln Pro Val

15

<210> 5010

<211> 9

<212>PRT

<213> Triticum species

<400> 5010

Glu Gly Ser Phe Gln Pro Ser Gln Glu

15

<210> 5011

<211> 9

<212>PRT

<213> Triticum species

<400> 5011

Glu Gln Pro Gln Gln Pro Phe Pro Gln

15

<210> 5012

<211> 9

<212>PRT

<213> Triticum species

<400> 5012

Glu Gln Pro Gln Gln Pro Tyr Pro Glu

15

<210> 5013

<211> 9

<212>PRT

<213> Triticum species

<400> 5013

Gln Phe Tyr Tyr Pro Thr Ser Pro Gln

15

<210> 5014

<211> 9

<212>PRT

<213> Triticum species

<400> 5014

Glu Gly Ser Phe Gln Pro Ser Gln Glu

15

<210> 5015

<211> 9

<212>PRT

<213> Triticum species

<400> 5015

Pro Gln Gln Ser Phe Pro Glu Gln Glu

15

<210> 5016

<211> 9

<212>PRT

<213> Triticum species

<400> 5016

Gln Phe Tyr Tyr Pro Thr Ser Pro Gln

15

<210> 5017

<211> 239

<212>PRT

<213> Homo sapiens

<400> 5017

Arg Gly Asp Ser Gly Ser Pro Ala Thr Trp Thr Thr Arg Gly Phe Val

1 5 10 15

Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro Ser Cys Pro Glu Gly

20 25 30

Thr Val Pro Leu Tyr Ser Gly Phe Ser Phe Leu Phe Val Gln Gly Asn

35 40 45

Gln Arg Ala His Gly Gln Asp Leu Gly Thr Leu Gly Ser Cys Leu Gln

50 55 60

Arg Phe Thr Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys

65 70 75 80

Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser Thr Pro Ala

85 90 95

Leu Met Pro Met Asn Met Ala Pro Ile Thr Gly Arg Ala Leu Glu Pro

100 105 110

Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly Pro Ala Ile Ala Ile Ala

115 120 125

Val His Ser Gln Thr Thr Asp Ile Pro Pro Cys Pro His Gly Trp Ile

130 135 140

Ser Leu Trp Lys Gly Phe Ser Phe Ile Met Phe Thr Ser Ala Gly Ser

145 150 155 160

Glu Gly Thr Gly Gln Ala Leu Ala Ser Pro Gly Ser Cys Leu Glu Glu

165 170 175

Phe Arg Ala Ser Pro Phe Leu Glu Cys His Gly Arg Gly Thr Cys Asn

180 185 190

Tyr Tyr Ser Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn Pro Glu

195 200 205

Arg Met Phe Arg Lys Pro Ile Pro Ser Thr Val Lys Ala Gly Glu Leu

210 215 220

Glu Lys Ile Ile Ser Arg Cys Gln Val Cys Met Lys Lys Arg His

225 230 235

<210> 5018

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5018

Ser Pro Ala Thr Trp Thr Thr Arg Gly Phe Val Phe Thr Arg His Ser

1 5 10 15

Gln Thr Thr Ala

20

<210> 5019

<211> 21

<212>PRT

<213> Homo sapiens

<400> 5019

Val Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro Ser Cys Pro Glu

1 5 10 15

Gly Thr Val Pro Leu

20

<210> 5020

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5020

Ile Pro Ser Cys Pro Glu Gly Thr Val Pro Leu Tyr Ser Gly Phe Ser

1 5 10 15

Phe Leu Phe Val

20

<210> 5021

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5021

Leu Tyr Ser Gly Phe Ser Phe Leu Phe Val Gln Gly Asn Gln Arg Ala

1 5 10 15

His Gly Gln Asp

20

<210> 5022

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5022

Phe Thr Thr Met Pro Phe Leu Phe Cys Asn Val Asn Asp Val Cys Asn

1 5 10 15

Phe Ala Ser Arg

20

<210> 5023

<211> 21

<212>PRT

<213> Homo sapiens

<400> 5023

Val Asn Asp Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp

1 5 10 15

Leu Ser Thr Pro Ala

20

<210> 5024

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5024

Thr Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu

1 5 10 15

Gly Pro Ala Ile

20

<210> 5025

<211> 19

<212>PRT

<213> Homo sapiens

<400> 5025

Arg Cys Thr Val Cys Glu Pro Ala Ile Ala Ile Ala Val His Ser Gln

1 5 10 15

Thr Thr Asp

<210> 5026

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5026

Ile Pro Pro Cys Pro His Gly Trp Ile Ser Leu Trp Lys Gly Phe Ser

1 5 10 15

Phe Ile Met Phe

20

<210> 5027

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5027

Leu Trp Lys Gly Phe Ser Phe Ile Met Phe Thr Ser Ala Gly Ser Glu

1 5 10 15

Gly Thr Gln Gly

20

<210> 5028

<211> 20

<212>PRT

<213> Homo sapiens

<400> 5028

Asn Ser Tyr Ser Phe Trp Leu Ala Ser Leu Asn Pro Glu Arg Met Phe

1 5 10 15

Arg Lys Pro Ile

20

<210> 5029

<211> 19

<212>PRT

<213> Mus musculus

<400> 5029

Ala Thr Gly Thr Arg Met Arg Gly Phe Ile Phe Thr Arg His Ser Thr

1 5 10 15

Thr Ala Ile

<210> 5030

<211> 20

<212>PRT

<213> Mus musculus

<400> 5030

Phe Ile Phe Thr Arg His Ser Gln Thr Thr Ala Ile Pro Ser Cys Pro

1 5 10 15

Glu Gly Thr Gln

20

<210> 5031

<211> 20

<212>PRT

<213> Mus musculus

<400> 5031

Thr Thr Ala Ile Pro Ser Cys Pro Glu Gly Thr Gln Pro Leu Tyr Ser

1 5 10 15

Gly Phe Ser Leu

20

<210> 5032

<211> 20

<212>PRT

<213> Mus musculus

<400> 5032

Glu Gly Thr Gln Pro Leu Tyr Ser Gly Phe Ser Leu Leu Phe Val Gln

1 5 10 15

Gly Asn Lys Arg

20

<210> 5033

<211> 20

<212>PRT

<213> Mus musculus

<400> 5033

Phe Leu Phe Cys Asn Ile Asn Asn Val Cys Asn Phe Ala Ser Arg Asn

1 5 10 15

Asp Tyr Ser Tyr

20

<210> 5034

<211> 20

<212>PRT

<213> Mus musculus

<400> 5034

Val Cys Asn Phe Ala Ser Arg Asn Asp Tyr Ser Tyr Trp Leu Ser Thr

1 5 10 15

Pro Ala Leu Met

20

<210> 5035

<211> 20

<212>PRT

<213> Mus musculus

<400> 5035

Ala Pro Ile Ser Gly Arg Ala Leu Glu Pro Tyr Ile Ser Arg Cys Thr

1 5 10 15

Val Cys Glu Gly

20

<210> 5036

<211> 20

<212>PRT

<213> Mus musculus

<400> 5036

Glu Pro Tyr Ile Ser Arg Cys Thr Val Cys Glu Gly Pro Ala Met Ala

1 5 10 15

Ile Ala Val His

20

<210> 5037

<211> 20

<212>PRT

<213> Mus musculus

<400> 5037

Ala Ile Pro Pro Cys Pro Gln Asp Trp Val Ser Leu Trp Lys Gly Phe

1 5 10 15

Ser Phe Ile Met

20

<210> 5038

<211> 21

<212>PRT

<213> Mus musculus

<400> 5038

Trp Val Ser Leu Trp Lys Gly Glu Phe Ser Phe Ile Met Phe Thr Ser

1 5 10 15

Ala Gly Ser Glu Gly

20

<210> 5039

<211> 20

<212>PRT

<213> Mus musculus

<400> 5039

Ser Phe Trp Leu Ala Ser Leu Asn Pro Glu Arg Met Phe Arg Lys Pro

1 5 10 15

Ile Pro Ser Thr

20

<210> 5040

<211> 20

<212>PRT

<213> Triticum species

<400> 5040

Pro Gln Pro Phe Pro Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro

1 5 10 15

Tyr Pro Gln Pro

20

<210> 5041

<211> 20

<212>PRT

<213> Triticum species

<400> 5041

Met Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro

1 5 10 15

Gln Leu Pro Tyr

20

<210> 5042

<211> 20

<212>PRT

<213> Triticum species

<400> 5042

Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Trp Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5043

<211> 20

<212>PRT

<213> Triticum species

<400> 5043

Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Ile Pro

1 5 10 15

Val Gln Pro Gln

20

<210> 5044

<211> 20

<212>PRT

<213> Triticum species

<400> 5044

Pro Gln Gln Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Ser Gln

1 5 10 15

Gln Pro Gln Gln

20

<210> 5045

<211> 20

<212>PRT

<213> Triticum species

<400> 5045

Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Leu Pro Phe Pro Gln

1 5 10 15

Gln Ser Glu Gln

20

<210> 5046

<211> 20

<212>PRT

<213> Triticum species

<400> 5046

Trp Pro Gln Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Cys Gln

1 5 10 15

Gln Pro Gln Gln

20

<210> 5047

<211> 20

<212>PRT

<213> Triticum species

<400> 5047

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Ser Gln Pro

1 5 10 15

Gln Pro Phe Arg

20

<210> 5048

<211> 20

<212>PRT

<213> Triticum species

<400> 5048

Leu Gln Pro Phe Pro Gln Pro Gln Pro Phe Leu Pro Gln Leu Pro Tyr

1 5 10 15

Pro Gln Pro Gln

20

<210> 5049

<211> 20

<212>PRT

<213> Triticum species

<400> 5049

Ser Gln Gln Pro Gln Gln Gln Phe Ser Gln Pro Gln Gln Gln Phe Pro

1 5 10 15

Gln Pro Gln Gln

20

<210> 5050

<211> 20

<212>PRT

<213> Triticum species

<400> 5050

Gln Ala Phe Pro Gln Pro Gln Gln Thr Phe Pro His Gln Pro Gln Gln

1 5 10 15

Gln Phe Pro Gln

20

<210> 5051

<211> 20

<212>PRT

<213> Triticum species

<400> 5051

Cys Lys Val Phe Leu Gln Gln Gln Cys Ser Pro Val Ala Met Pro Gln

1 5 10 15

Arg Leu Ala Arg

20

<210> 5052

<211> 20

<212>PRT

<213> Triticum species

<400> 5052

Leu Gln Leu Gln Pro Phe Pro Gln Pro Gln Leu Pro Tyr Leu Gln Pro

1 5 10 15

Gln Pro Phe Arg

20

<210> 5053

<211> 20

<212>PRT

<213> Triticum species

<400> 5053

Gln Gln Gln Phe Ile Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln

1 5 10 15

Gln Thr Tyr Pro

20

<210> 5054

<211> 20

<212>PRT

<213> Triticum species

<400> 5054

Ser His Ile Pro Gly Leu Glu Arg Pro Trp Gln Gln Gln Pro Leu Pro

1 5 10 15

Pro Gln Gln Thr

20

<210> 5055

<211> 20

<212>PRT

<213> Triticum species

<400> 5055

Ser Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Gln Phe Pro

1 5 10 15

Gln Pro Gln Gln

20

<210> 5056

<211> 20

<212>PRT

<213> Triticum species

<400> 5056

Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Gln Leu Pro Phe Pro Gln

1 5 10 15

Gln Pro Gln Gln

20

<210> 5057

<211> 20

<212>PRT

<213> Triticum species

<400> 5057

Pro Gln Leu Pro Tyr Pro Gln Pro Gln Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

Pro Phe Arg Pro

20

<210> 5058

<211> 20

<212>PRT

<213> Triticum species

<400> 5058

Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Trp Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5059

<211> 20

<212>PRT

<213> Triticum species

<400> 5059

Phe Pro Glu Leu Gln Gln Pro Ile Pro Gln Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Leu Gln Pro

20

<210> 5060

<211> 20

<212>PRT

<213> Triticum species

<400> 5060

Gln Gly Gln Gln Gly Tyr Tyr Pro Ile Ser Pro Gln Gln Ser Gly Gln

1 5 10 15

Gly Gln Gln Pro

20

<210> 5061

<211> 20

<212>PRT

<213> Triticum species

<400> 5061

Leu Gln Pro Gly Gln Gly Gln Pro Gly Tyr Tyr Pro Thr Ser Pro Gln

1 5 10 15

Gln Ile Gly Gln

20

<210> 5062

<211> 20

<212>PRT

<213> Triticum species

<400> 5062

Gln Gln Phe Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10 15

Pro Tyr Pro Gln

20

<210> 5063

<211> 20

<212>PRT

<213> Triticum species

<400> 5063

Pro Gly Gln Gly Gln Ser Gly Tyr Tyr Pro Thr Ser Pro Gln Gln Ser

1 5 10 15

Gly Gln Lys Gln

20

<210> 5064

<211> 20

<212>PRT

<213> Triticum species

<400> 5064

Thr Pro Ile Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro

1 5 10 15

Gln Gln Pro Phe

20

<210> 5065

<211> 20

<212>PRT

<213> Triticum species

<400> 5065

Pro Gln Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Gln Gln Pro

20

<210> 5066

<211> 20

<212>PRT

<213> Triticum species

<400> 5066

Pro Phe Thr Gln Pro Gln Gln Pro Thr Pro Ile Gln Pro Gln Gln Pro

1 5 10 15

Phe Pro Gln Gln

20

<210> 5067

<211> 20

<212>PRT

<213> Triticum species

<400> 5067

Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Thr Phe Pro Gln Gln Pro

1 5 10 15

Gln Leu Pro Phe

20

<210> 5068

<211> 20

<212>PRT

<213> Triticum species

<400> 5068

Gly Gln Gly Gln Ser Gly Tyr Tyr Pro Thr Ser Pro Gln Gln Ser Gly

1 5 10 15

Gln Glu Ala Thr

20

<210> 5069

<211> 20

<212>PRT

<213> Triticum species

<400> 5069

Pro Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Gln Pro Gln

20

<210> 5070

<211> 20

<212>PRT

<213> Triticum species

<400> 5070

Gln Pro Phe Pro Gln Leu Gln Gln Pro Gln Gln Pro Leu Pro Gln Pro

1 5 10 15

Gln Gln Pro Gln

20

<210> 5071

<211> 20

<212>PRT

<213> Triticum species

<400> 5071

Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10 15

Gln Pro Ile Pro

20

<210> 5072

<211> 20

<212>PRT

<213> Triticum species

<400> 5072

Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Thr Phe Pro Gln Gln Pro

1 5 10 15

Gln Leu Pro Phe

20

<210> 5073

<211> 20

<212>PRT

<213> Triticum species

<400> 5073

Val Ala His Ala Ile Ile Met His Gln Gln Gln Gln Gln Gln Gln Glu

1 5 10 15

Gln Lys Gln Gln

20

<210> 5074

<211> 20

<212>PRT

<213> Triticum species

<400> 5074

Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln Gln Phe Pro Gln Pro

1 5 10 15

Gln Gln Pro Gln

20

<210> 5075

<211> 20

<212>PRT

<213> Triticum species

<400> 5075

Gln Gln Pro Ala Gln Tyr Glu Val Ile Arg Ser Leu Val Leu Arg Thr

1 5 10 15

Leu Pro Asn Met

20

<210> 5076

<211> 20

<212>PRT

<213> Triticum species

<400> 5076

Ala Thr Ala Asn Met Gln Val Asp Pro Ser Gly Gln Val Gln Trp Pro

1 5 10 15

Gln Gln Gln Pro

20

<210> 5077

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5077

Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Trp Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5078

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5078

Trp Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Pro Leu

1 5 10 15

Gln Pro Gln Gln

20

<210> 5079

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5079

Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Ile Pro Tyr Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5080

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5080

Gln Pro Gln Gln Pro Gln Pro Phe Pro Gln Gln Pro Val Pro Gln Gln

1 5 10 15

Pro Gln Pro Tyr

20

<210> 5081

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5081

Pro Gln Pro Phe Pro Gln Gln Pro Ile Pro Gln Gln Pro Gln Pro Tyr

1 5 10 15

Pro Gln Gln Pro

20

<210> 5082

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5082

Gln Gln Pro Gln Pro Phe Ser Gln Gln Pro Ile Pro Gln Gln Pro Gln

1 5 10 15

Pro Tyr Pro Gln

20

<210> 5083

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5083

Gln Ser Gln Gln Gln Phe Pro Gln Pro Gln Gln Pro Phe Pro Gln Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5084

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5084

Pro Gln Pro Phe Pro Gln Gln Pro Ile Pro Gln Gln Pro Gln Pro Tyr

1 5 10 15

Pro Gln Gln Pro

20

<210> 5085

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5085

Gln Gln Pro Phe Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Pro Tyr

1 5 10 15

Pro Gln Gln Pro

20

<210> 5086

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5086

Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe Ser

1 5 10 15

Trp Gln Pro Gln

20

<210> 5087

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5087

Gln Pro Gln Pro Tyr Pro Gln Gln Pro Gln Pro Tyr Pro Gln Gln Pro

1 5 10 15

Phe Gln Pro Gln

20

<210> 5088

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5088

Gln Gln Pro Phe Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Pro Tyr

1 5 10 15

Pro Gln Gln Pro

20

<210> 5089

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5089

Pro Gln Pro Tyr Pro Gln Gln Pro Gln Pro Phe Pro Gln Gln Pro Pro

1 5 10 15

Phe Cys Gln Gln

20

<210> 5090

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5090

Phe Gln Gln Pro Gln Gln Ser Tyr Pro Val Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Gln Pro Gln

20

<210> 5091

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5091

Tyr Pro Gln Gln Pro Gln Pro Phe Pro Gln Gln Pro Ile Pro Gln Gln

1 5 10 15

Pro Gln Pro Tyr

20

<210> 5092

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5092

Gln Gln Gln Pro Phe Pro Gln Gln Pro Ile Pro Gln Gln Pro Gln Pro

1 5 10 15

Tyr Pro Gln Gln

20

<210> 5093

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5093

Gln Pro Gln Gln Pro Gln Pro Phe Pro Gln Gln Pro Val Pro Gln Gln

1 5 10 15

Pro Gln Pro Tyr

20

<210> 5094

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5094

Gln Pro Gln Pro Phe Pro Gln Gln Pro Ile Pro Leu Gln Pro His Gln

1 5 10 15

Pro Tyr Thr Gln

20

<210> 5095

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5095

Leu Pro Arg Pro Gln Gln Pro Phe Pro Trp Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Gln Pro Gln

20

<210> 5096

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5096

Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5097

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5097

Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro

1 5 10 15

Phe Arg Gln Gln

20

<210> 5098

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5098

Pro Gln Gln Pro Phe Gln Pro Gln Gln Pro Phe Pro Gln Gln Thr Ile

1 5 10 15

Pro Gln Gln Pro

20

<210> 5099

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5099

Asn Pro Leu Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Pro Pro

1 5 10 15

Gln Gln Pro Phe

20

<210> 5100

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5100

Asn Pro Leu Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Pro Pro

1 5 10 15

Gln Gln Pro Phe

20

<210> 5101

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5101

Pro Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro

1 5 10 15

Phe Arg Gln Gln

20

<210> 5102

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5102

Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro Phe Pro Trp

1 5 10 15

Gln Pro Gln Gln

20

<210> 5103

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5103

Thr Phe Pro Pro Ser Gln Gln Pro Asn Pro Leu Gln Pro Gln Gln Pro

1 5 10 15

Phe Pro Leu Gln

20

<210> 5104

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5104

Pro Gln Gln Thr Ile Pro Gln Gln Pro Gln Gln Pro Phe Pro Leu Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5105

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5105

Gln Pro Gln Gln Pro Phe Ser Phe Ser Gln Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Leu Gln Pro

20

<210> 5106

<211> 20

<212>PRT

<213> Hordeum vulgare

<400> 5106

Gln Gln Pro Phe Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Pro Tyr

1 5 10 15

Pro Gln Gln Pro

20

<210> 5107

<211> 20

<212>PRT

<213> Secale cereale

<400> 5107

Gln Gln Leu Pro Leu Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln

1 5 10 15

Pro Ile Pro Gln

20

<210> 5108

<211> 20

<212>PRT

<213> Secale cereale

<400> 5108

Ser Ile Pro Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro Phe

1 5 10 15

Pro Gln Ser Gln

20

<210> 5109

<211> 20

<212>PRT

<213> Secale cereale

<400> 5109

Gln Pro Phe Pro Gln Pro Gln Gln Pro Thr Pro Ile Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5110

<211> 20

<212>PRT

<213> Secale cereale

<400> 5110

Gln Pro Phe Pro Gln Pro Gln Gln Pro Thr Pro Ile Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5111

<211> 20

<212>PRT

<213> Secale cereale

<400> 5111

Pro Ala Pro Ile Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5112

<211> 20

<212>PRT

<213> Secale cereale

<400> 5112

Pro Gln Gln Pro Phe Pro Gln Gln Pro Glu Gln Ile Ile Pro Gln Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5113

<211> 20

<212>PRT

<213> Secale cereale

<400> 5113

Gln Tyr Ser Pro Tyr Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln

1 5 10 15

Pro Thr Pro Ile

20

<210> 5114

<211> 20

<212>PRT

<213> Secale cereale

<400> 5114

Ser Gln Gln Pro Gln Arg Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln

1 5 10 15

Gln Ile Ile Pro

20

<210> 5115

<211> 20

<212>PRT

<213> Secale cereale

<400> 5115

Gln Gln Leu Pro Leu Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln

1 5 10 15

Pro Ile Pro Gln

20

<210> 5116

<211> 20

<212>PRT

<213> Secale cereale

<400> 5116

Phe Pro Leu Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Glu Gln Ile

1 5 10 15

Ile Ser Gln Gln

20

<210> 5117

<211> 20

<212>PRT

<213> Secale cereale

<400> 5117

Pro Gln Gln Pro Phe Pro Gln Gln Pro Glu Gln Ile Ile Pro Gln Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5118

<211> 20

<212>PRT

<213> Secale cereale

<400> 5118

Phe Pro Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Gln Leu

1 5 10 15

Pro Leu Gln Pro

20

<210> 5119

<211> 20

<212>PRT

<213> Secale cereale

<400> 5119

Ser Pro Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro Phe Pro Gln Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5120

<211> 20

<212>PRT

<213> Secale cereale

<400> 5120

Gln Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro Val Pro

1 5 10 15

Gln Gln Pro Gln

20

<210> 5121

<211> 20

<212>PRT

<213> Secale cereale

<400> 5121

Gln Pro Gln Gln Ile Ile Pro Gln Gln Pro Gln Gln Pro Phe Pro Leu

1 5 10 15

Gln Pro Gln Gln

20

<210> 5122

<211> 20

<212>PRT

<213> Secale cereale

<400> 5122

Pro Gln Gln Pro Phe Pro Gln Gln Pro Glu Gln Ile Ile Pro Gln Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5123

<211> 20

<212>PRT

<213> Secale cereale

<400> 5123

Gln Thr Gln Gln Ser Ile Pro Gln Pro Gln Gln Pro Phe Pro Gln Pro

1 5 10 15

Gln Gln Pro Phe

20

<210> 5124

<211> 20

<212>PRT

<213> Secale cereale

<400> 5124

Gln Gln Pro Phe Leu Leu Gln Pro Gln Gln Pro Phe Ser Gln Pro Gln

1 5 10 15

Gln Pro Phe Leu

20

<210> 5125

<211> 20

<212>PRT

<213> Secale cereale

<400> 5125

Gln Gln Pro Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro Val Pro

1 5 10 15

Gln Gln Pro Gln

20

<210> 5126

<211> 20

<212>PRT

<213> Secale cereale

<400> 5126

Glu Gln Ile Ile Ser Gln Gln Pro Phe Pro Leu Gln Pro Gln Gln Pro

1 5 10 15

Phe Ser Gln Pro

20

<210> 5127

<211> 20

<212>PRT

<213> Secale cereale

<400> 5127

Asn Met Gln Val Gly Pro Ser Gly Gln Val Glu Trp Pro Gln Gln Gln

1 5 10 15

Pro Leu Pro Gln

20

<210> 5128

<211> 20

<212>PRT

<213> Secale cereale

<400> 5128

Pro Gln Gln Leu Phe Pro Leu Pro Gln Gln Pro Phe Pro Gln Pro Gln

1 5 10 15

Gln Pro Phe Pro

20

<210> 5129

<211> 20

<212>PRT

<213> Secale cereale

<400> 5129

Pro Gln Thr Gln Gln Pro Gln Gln Pro Phe Pro Gln Pro Gln Gln Pro

1 5 10 15

Gln Gln Leu Phe

20

<210> 5130

<211> 20

<212>PRT

<213> Secale cereale

<400> 5130

Ser Pro Gln Gln Pro Gln Leu Pro Phe Pro Gln Pro Gln Gln Pro Phe

1 5 10 15

Val Val Val Val

20

<210> 5131

<211> 20

<212>PRT

<213> Secale cereale

<400> 5131

Phe Pro Gln Gln Pro Glu Gln Ile Ile Ser Gln Gln Pro Gln Gln Pro

1 5 10 15

Phe Pro Leu Gln

20

<210> 5132

<211> 20

<212>PRT

<213> Secale cereale

<400> 5132

Pro Ala Pro Ile Gln Pro Gln Gln Pro Phe Pro Gln Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5133

<211> 20

<212>PRT

<213> Secale cereale

<400> 5133

Pro Gln Glu Pro Gln Gln Leu Phe Pro Gln Ser Gln Gln Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5134

<211> 20

<212>PRT

<213> Secale cereale

<400> 5134

Ser Pro Gln Pro Gln Gln Pro Tyr Pro Gln Gln Pro Phe Pro Gln Gln

1 5 10 15

Pro Gln Gln Pro

20

<210> 5135

<211> 20

<212>PRT

<213> Secale cereale

<400> 5135

Pro Thr Pro Ile Gln Pro Gln Gln Pro Phe Pro Gln Arg Pro Gln Gln

1 5 10 15

Pro Phe Pro Gln

20

<210> 5136

<211> 15

<212>PRT

<213> Artificial sequence

<220>

<223> NPL033

<400> 5136

Leu Gln Pro Phe Pro Gln Pro Glu Leu Pro Tyr Pro Gln Pro Gln

1 5 10 15

<210> 5137

<211> 14

<212>PRT

<213> Artificial sequence

<220>

<223> NPL038

<400> 5137

Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Pro Trp Gln Pro

1 5 10

<210> 5138

<211> 15

<212>PRT

<213> Artificial sequence

<220>

<223>NPL034

<400> 5138

Pro Glu Gln Pro Ile Pro Glu Gln Pro Gln Pro Tyr Pro Gln Gln

1 5 10 15

<210> 5139

<211> 16

<212>PRT

<213> Artificial sequence

<220>

<223> peptide derived from gluten

<400> 5139

Pro Gln Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Pro Trp Gln Pro

1 5 10 15

<210> 5140

<211> 16

<212>PRT

<213> Artificial sequence

<220>

<223> peptide derived from gluten

<400> 5140

Phe Pro Glu Gln Pro Ile Pro Glu Gln Pro Gln Pro Tyr Pro Gln Gln

1 5 10 15

<---

Claims (13)

1. A tolerogenic particle for inducing antigen-specific tolerance in a subject in need thereof, comprising one or more encapsulated antigens, wherein the particle has a negative zeta potential of -80 mV to -30 mV, and wherein said particle has a diameter of from 200 to 2000 nanometers, where the antigen is an autoimmune antigen, an enzyme intended for enzyme replacement therapy, or an allergen and where the particle contains polylactic acid (PLA), polyglycolic acid (PGA), copolymer of lactide-glycolide (PLG) or liposome. 2. A tolerogenic particle according to claim 1, where said particle has a diameter of 400 to 800 nanometers. 3. The tolerogenic particle of claim 1, wherein the antigen comprises at least a portion of a protein selected from the group consisting of: myelin basic protein, acetylcholine receptor, endogenous antigen, myelin oligodendrocyte glycoprotein, pancreatic beta cell antigen, insulin, glutamate decarboxylase (GAD), collagen type 11, human cartilage gp39, fp130-RAPS, proteolipid protein, fibrillarin, small nucleolar protein, thyroid-stimulating factor receptor, histones, gp70 glycoprotein, pyruvate dehydrogenase-dihydrolipoamide acetyltransferase (PCD-E2), hair follicle antigen, A-gliadin , gliadin, proinsulin, islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), human tropomyosin isoform 5, buckwheat pollen notable (BaGP), peach allergen Pru p 3, milk allergen alpha-s1-casein, allergen celery Api g 1, Brazil nut allergen Bere1, milk allergen B-lactoglobulin, bovine serum albumin, hazelnut allergen Cor a 1.04, myelin associated glycoprotein, aquaporin, type IV collagen α3 chain, egg allergen ovalbumin, advat, antihemophilic factor, cogenate, eloctate, recombinant factor VIII and Fc fusion protein, refacto, Novo VIIa, recombinant factor VII, eptacog alpha, helixate, monanin, coagulation factor IX, vilate, ceredase, agglucerase, cerezim, imiglucerase, Elelso, taliglucerase alpha, fabrazyme, agalsidase beta, aldurazyme, alpha-L-iduronidase, myozyme, acid glucosidase, elaprase, iduronate-2-sulfatase, naglazyme arylsulfatase B or N-acetylgalactosamine-4-sulfatase. 4. The tolerogenic particle of claim 1, wherein the particle comprises a lactide-glycolide (PLG) copolymer, wherein optionally the particle comprises PLG with a 50:50 ratio of polylactic acid:polyglycolic acid in the copolymer. 5. The tolerogenic particle of claim 1, wherein the particle is surface functionalized, wherein the surface functionalization is optionally carboxylation. 6. The tolerogenic particle according to claim 1, where the particle has a zeta potential of -50 mV to -40 mV. 7. The tolerogenic particle according to claim 1, where the particle has a zeta potential of -75 mV to -30 mV. 8. Tolerogenic particle according to claim 1, additionally containing pharmaceutically acceptable excipients. 9. The tolerogenic particle of claim 7, wherein the particle comprises a lactide-glycolide (PLG) copolymer, and wherein said PLG particle has a lactide:glycolide copolymer ratio of 50:50, wherein optionally i) the diameter of said PLG particle is between 400 to 800 nanometers or ii) where the surface functionalization is carboxylation, where optionally carboxylation is provided through the use of poly(ethylene maleic anhydride) (PEMA). 10. The tolerogenic particle according to claim 1, where the particle is lyophilized, and where the particle has a zeta potential of -70 mV to -30 mV. 11. The tolerogenic particle of claim 10, wherein the particle comprises a lactide-glycolide (PLG) copolymer, and wherein said PLG particle has a lactide:glycolide copolymer ratio of 50:50. 12. The tolerogenic particle of claim 1, wherein the particle is lyophilized, and wherein the particle is reconstituted and administered to said subject in need thereof. 13. The tolerogenic particle according to claim 1, where the antigen is associated with a disease or disorder selected from the group consisting of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type I diabetes mellitus, type II diabetes mellitus, multiple sclerosis (MS ), immune-mediated infertility such as premature ovarian failure, scleroderma, Sjogren's disease, vitiligo, alopecia, polyglandular insufficiency, Graves' disease, hypothyroidism, polymyositis, pemphigus vulgaris, pemphigus foliaceus, inflammatory bowel disease, including Crohn's disease and ulcerative colitis, autoimmune hepatitis, including hepatitis B virus (HBV) and hepatitis C virus (HCV) related, hypopituitarism, graft-versus-host disease (GvHD), myocarditis, Addison's disease, autoimmune skin diseases, uveitis, pernicious anemia, celiac disease, hypoparathyroidism, neuromyelitis optica, membranous nephropathy, bullous pemphigoid, pemphigus vulgaris, myasthenia gravis, Hashimoto's thyroiditis, autoimmune polyglandular syndromes type I and type II, paraneoplastic pemphigus, bullous pemphigus, dermatitis herpetiformis, linear IgA dermatosis, epidermolysis bullosa acquisitas, erythema nodosum, pemphigoid and in pregnant women, cicatricial pemphigoid, essential cryoglobulinemia of mixed type, chronic bullous disease of childhood, hemolytic anemia, thrombocytopenic purpura, Goodpasture's syndrome, autoimmune neutropenia, myasthenia gravis, Eaton-Lambert myasthenic syndrome, muscle stiffness syndrome, acute disseminated encephalomyelitis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyradiculones ropathy, multifocal motor neuropathy with conduction block, chronic neuropathy with monoclonal gammopathy, opsoclonic-myoclonic syndrome, cerebellar degeneration, encephalomyelitis, retinopathy, primary biliary sclerosis, sclerosing cholangitis, gluten-dependent enteropathy, ankylosing spondylitis, reactive arthritis, polymyositis/dermatomyositis, mixed no connective tissue disease, Behçet's syndrome, psoriasis, polyarteritis nodosa, allergic angiitis and granulomatosis, Churg-Strauss disease, overlap polyangiitis syndrome, allergic vasculitis, Wegener's granulomatosis, temporal arteritis, Takayasu arteritis, Kawasaki disease, isolated vasculitis of the central nervous system, thromboangiitis obliterans, sarcoidosis , glomerulonephritis, cryopathies, allergic disease or condition, allergies and asthma.