RU2604938C2 - Contactless pupillometr for screening diagnosis of functional status of an organism and method of its use - Google Patents

Contactless pupillometr for screening diagnosis of functional status of an organism and method of its use Download PDF

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RU2604938C2
RU2604938C2 RU2015107892/14A RU2015107892A RU2604938C2 RU 2604938 C2 RU2604938 C2 RU 2604938C2 RU 2015107892/14 A RU2015107892/14 A RU 2015107892/14A RU 2015107892 A RU2015107892 A RU 2015107892A RU 2604938 C2 RU2604938 C2 RU 2604938C2
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pupil
white light
reaction
light source
non
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RU2015107892/14A
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RU2015107892A (en
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Александр Владимирович Туголуков
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Общество с ограниченной ответственностью "КВАЗАР"
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement

Abstract

FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine. Contactless pupillometr for screening diagnosis of functional state of the body comprises a body, holder, radiator, receiver, temperature sensor, chamber, housing, position indicator, two infrared (IR) light-emitting diode, red light-emitting diode, source of white light, light sensors and computer with software. Body is made of complex shape, which can be divided into two surfaces, forming shield and enclosing boards. Front end side of shield of body has concave shape, that is, in plan is represented by arc in the centre of which there is a temperature sensor, and at the edges are symmetrically arranged radiator and receiver respectively, to that light flux of radiator falls directly on the receiver. Radiator is represented by photo electrosensor, generating light flux. Receiver is represented by photo electrosensor, receiving light flux from the radiator. Temperature sensor is represented by infrared thermometer providing non-contact measurement of temperature. In the inner part of the protecting casing at the center there is a chamber in the casing and position indicator, and on side opposite from the chamber is mounted two infrared light-emitting diode. Casing is made of material capable of uniform distribution of light. Position indicator is located above the chamber and is made of material, surface of the profiled sides of which has a reflecting capacity, with a degree of definition sufficient for reflecting eye contours. Two IR light-emitting diode operate in the range of infrared light, and perform function of constant continuous illumination of right and left eye, respectively. In the upper part of the body there is a light sensor. On rear wall of casing behind the chamber are located red light-emitting diode and a source of white light. When covering the light flux from the emitter to the receiver is activated red light-emitting diode. Enclosing boards of the housing together with a shield, as well as with two IR light-emitting diodes and illumination sensor are created and measured the condition of background illumination. Contactless method of screening diagnosis of functional state of an organism comprises the step of pre-research, stage of analysis and a enclosing step. At the stage of pre-research are carried out registration of identification code of a person, under which information is stored in the future; positioning of the person being tested and creation of background illumination, for this purpose, the person being tested, at continuous operation of two IR light-emitting diodes, not touching surfaces of the case and seeing reflection of the eye on the indicator position, bringing its head to the front end side of the shield body until it overlaps the beam path from the emitter to receiver, thus activating operation of red light-emitting diode. At the stage of analysis, at continuous operation of red light-emitting diode and brighting-up eyes IR light-emitting diodes, is carryed out contactless continuous simultaneous measurement of background lighting readings, temperature of the human body and the pupil reaction of eye in three series changed modes: adaptation, load and reduction. Mode of adaptation lasts from the moment of switching on red light-emitting diode to the moment of switching on white light source; load mode is characterised by the operation of turned-on white light source; recovery mode lasts from the moment of turn off white light source to the moment of blinking red light-emitting diode. At the stage of conclusion is carried out entering in the database of PC under the patient's identification code of measurement. Processing and analysis of measurements. At the same time for measuring the pupil reaction is carried out processing of each image frame in digital form at pixels and by statistical processing of plotting the change of area of the pupil in time, depending on illumination. Then calculation is performed, at least, the following parameters: latent pupil reaction time on white light source (Tlat1), latent pupil reaction time at disconnection of white light source (Tlat2), angle of the pupil reaction on activation of white light source (F1), angle of the pupil reaction on deactivation of white light source (F2), coefficient of reaction (AmplRatio), average area of the pupil before reaction (Average). Then, at least on five researches is carried out formation of individual norms of the testing patient, in which for each value Tlat1, Tlat2, F1, F2, AmplRatio, Average minimum and maximum values are defined with allowance in 10%. During repeated examination is carried out automatic comparison of design parameters of pupillary response of the investigated with the same individual normal values with the issuance epicrisis of functional status of an organism.
EFFECT: using the given group of inventions allows increase accuracy of measurements, as well as reduce the time of examination.
11 cl, 9 dwg, 2 ex

Description

The invention relates to medical equipment that allows you to register and analyze the dependence of changes in pupillary reactions from toxic, physical, psycho-emotional, somatic and other factors affecting the body, and can be used in the field of medicine, narcology, legal psychology, forensic science, forensic science, labor psychology and so forth

Measuring the diameter of the pupil (pupillometry) is an objective method for studying the functional state of the body. Numerous studies have shown high informativeness of pupillographic indicators in assessing the functional state of the nervous system and the body as a whole. The reaction of the pupils to a light stimulus is an unconditioned reflex that cannot be controlled by the cerebral cortex. The pupil, being the diaphragm of the eye, regulates the luminous flux incident on the retina. In bright light, it narrows; when light intensity decreases, it expands. Many physical and chemical factors affect the rate of pupillary reaction. There is evidence of the specificity of pupillary reactions during intoxications, including narcotic (Kutsalo Anatoly Leonidovich. Pupillometry as a method of rapid diagnosis of drug intoxication: the dissertation of the candidate of medical sciences: 14.00.20 /: Institute of Toxicology. - St. Petersburg, 2004. - 118 p.: 40 ill. RSL OD).

Registration and mathematical processing of the results of the study of the pupil reflex present great difficulties in connection with the high rate of pupil reaction by the small size of the pupil.

Closest to the invention in technical essence is a method for recording pupil reactions and a device for its implementation (RU 2123797, 12/27/1998, class A61B 3/113), including fixing the subject’s head, lighting the pupil of the subject with infrared radiation, recording the reflected light flux with using an IR-sensitive television camera, applying a stimulus and recording a pupillogram with its subsequent processing. The television camera is pointed at the sharp image of the pupil, visually controlling it on the screen of the video monitoring device. Pupil sizes in absolute units are measured digitally in each frame of a television image, and for each subject, the initial set of pupillograms is recorded, according to which individual pupillometry standards are formed taking into account the type of stimulus used, and they are entered into the computer data bank. The parameters of the pupil reaction during subsequent recordings of pupillograms are automatically compared with individual pupillometry standards with the message “norm” or “deviation from the norm”.

The disadvantages of the known method and device are that they require visual control for their implementation and the choice of the type of stimulus in the process of registering pupillary reactions, which inevitably leads to the fixing of a specialist to each device for the entire period of the study.

The need to fix the head (contact with the device) introduces additional requirements for hygiene and sanitary standards during research.

The presence of a subjective approach to the control of the device, the conditions of background lighting during research and the absence of a housing as such leads to an error, and therefore, to a low accuracy of measurements in general.

Thus, the device and method known above do not allow widespread use in numerous mass examinations (for example, pre-shift and post-shift surveys of miners).

The technical result of the invention is expressed in improving the accuracy of measurements and objectification of the study, as well as reducing the time of examination and the complexity.

The proposed technical solution is illustrated by drawings,

 where in FIG. 1 shows the main view of a non-contact pupillometer;

in FIG. 2 shows a non-contact pupillometer (Top view);

in FIG. 3 - non-contact pupillometer (Profile projection);

in FIG. 4 - non-contact pupillometer (General view, isometry);

in FIG. 5 is a graph of changes in pupil area during testing;

figure 6 - the calculated values of Tlat1, Tlat2, F1, F2, AmplRatio, Average;

in FIG. 7 - the individual norm of the miner I. Ivanov for Example 1 and 2;

in FIG. 8 - research results of the miner Ivanov I.I. for Example 1;

in FIG. 9 - research results of the miner Ivanov I.I. for Example 2.

1 - the case of a non-contact pupillometer;

1a - visor of the housing of a non-contact pupillometer;

1b - enclosing sides of the case of a non-contact pupillometer;

1.1 - the front end side of the visor of the housing of the non-contact pupillometer;

1.2 - the inner part of the enclosing sides of the housing of a non-contact pupillometer;

2 - holder;

3 - emitter;

4 - receiver;

5 - temperature sensor;

6 - camera;

6a - camera lens;

7 - a casing;

8 - location indicator;

9 - IR LED;

10 - red LED;

11 - a source of white light;

12 - light sensor;

13 - PC with special software (not shown)

The claimed device, a non-contact pupillometer for screening diagnostics of the functional state of the body, consists of a housing (1) and a holder (2). The housing (1) is made of complex shape, which can conditionally be divided into two surfaces (1a) and (1b), where (1a) is the surface of the housing of a non-contact pupillometer (1) that forms a visor; (1b) - the surface of the housing of the non-contact pupillometer (1), forming the enclosing sides (around the visor). This form provides a compact placement of the components of the non-contact pupillometer device, as well as the necessary conditions for research.

The front end side of the visor of the housing (1.1) has a concave shape, that is, in the plan it is represented by an arc (see Fig.2,4,1), on the edges of which the emitter (3) and the receiver (4) are symmetrically placed, and is installed in the center temperature sensor (5). The emitter (3) is a photoelectric sensor that generates a luminous flux. The receiver (4) is a photoelectric sensor that receives the light flux from the emitter (3). Temperature sensor (5) is an infrared thermometer that provides non-contact temperature measurement.

Due to the concave shape of the front end side of the visor of the housing (1.1), the receiver (4) and the emitter (3) are located opposite each other so that the light flux of the emitter (3) directly hits the receiver (4).

The inner part of the enclosing sides of the case (1.2) is the part of the case (1) of the non-contact pupillometer, in which the camera (6) is located in the casing (7) and the location indicator (8), and two infrared mounted on the sides opposite the camera (6) (IR) LED (9), one element on each side. In this case, the position indicator (8) is located above the camera.

The casing (7) is made larger than the camera (6), while the camera lens (6a) is located outside the casing. On the back wall of the casing (7) behind the camera (6) there is a red LED (10) and a white light source (11). Two IR LEDs (9) operate in the range of infrared light (invisible to the human eye), while performing the function of constantly illuminating the right and left eyes, respectively (they operate continuously). The power of IR LEDs (9) is the range of values at which an image with maximum contrast is provided without interference (glare).

When the luminous flux is blocked from the emitter (3) to the receiver (4), the I red LED (10) is activated.

A continuously burning red LED (10) informs the subject about the beginning of the research phase, a blinking LED (10) informs the subject about the end of the research phase.

White light source (11) - illuminator or source of stimulus. The white light source (11) is designed for dosed exposure to the pupil of the eye with a light stimulus.

The casing (7) is made of a material capable of evenly distributing light from the elements (10) and (11) located in it, for example, from opaque plexiglass.

Camera (6) - provides registration of the pupil image in the infrared spectrum, while the frame rate should be at least 60 frames per second (60 fps), and the optical resolution should be at least 1.31 MPix.

The surface of the profile side of the location indicator (8) has a reflective ability, with a degree of clarity sufficient to reflect the contours of the eyes of the subject (as a fuzzy mirror). This degree of clarity reduces the effect of image flare. The shape of the position indicator (8) can be any, in this case it is a rectangular plate with a width equal to the width of the casing (7).

In the upper part of the casing (1) of the pupillometer there is a light sensor (12), which can be represented by a luxometer.

The enclosing sides of the housing (1b) together with the visor (1a), in which the front end side (1.1) has a concave shape, as well as with two IR LEDs (9) and an ambient light sensor (12) create the necessary physiological condition for background lighting during the study and allow evaluate it (measure). Thus, the claimed device provides contactless diagnostics of the functional state of the body in real time without the need for preliminary preparation and / or creation of additional conditions.

The holder (2) ensures the stability of the structure as a whole and the required height of the location, in particular, of the camera lens (6a) in the study. The height of the arrangement is selected so that the subject looked directly at the natural position of the head, and his eyes were on the same level as the location indicator (8). The holder design can be any one that meets the above requirements, for example, in the form of a tripod, stand, anchors (rear holders for mounting on the wall). In FIG. 1 shows the case when the holder is made in the form of a tripod.

The test subject is positioned in a non-contact manner. When the subject’s head blocks the path of the beam from the emitter (3) to the receiver (4), the red LED (10) is activated, while the subject fixes and sees his eyes on the location indicator (8). When positioning, the red LED (10) lights up continuously when triggered, thereby informing about the correct positioning and “about the beginning of the research phase”. The burning red LED (10) does not violate the conditions of background lighting due to the placement in the casing (7), which evenly scatters the light.

All components of a non-contact pupillometer for screening diagnostics of the functional state of the body are connected to a computer with special software (13) (not shown in the drawing). A PC with special software (13) provides real-time offline screening diagnostics of the functional state of the body, namely the following operations: determining the identity of the subject and recording the presence of health complaints;

- contactless positioning of the subject;

- automatic initiation of the start of the study;

- automatic non-contact measurement of background lighting;

- automatic non-contact measurement of the temperature sensor;

- automatic supply of a light stimulus by a white light source;

- non-contact measurement by the camera of pupillary reactions of the eye;

- automatic completion of the study;

- automatic storage, processing, analysis of measurements;

- automatic calculation of parameters;

- automatic formation of individual norms;

- issuance of an epicrisis.

The non-contact method of screening diagnostics of the functional state of the body is based on the registration of pupillary reactions and uses the above device for this.

The non-contact method of screening diagnostics of the functional state of the body is carried out in stages in the following sequence: pre-investigation, research and conclusion.

At the pre-investigation stage, the computer database (13) records the presence of health complaints and the identification code of the subject, under which information will be stored in the future.

The examinee is conveniently located on a chair or standing (depending on the design of the holder). The examinee brings his head closer to the front end side of the visor of the case (1.1), but does not touch it, and at the same time he fixes his gaze (that is, seeing the outlines of his eyes) on the location indicator (8). When the head covers the test light flux from the emitter (3) to the receiver (4), a red LED (10) is activated. When the red LED (10) is on, the subject stops his approach of the head to the front end side of the visor of the case (1.1).

In this situation, a zone with the necessary background lighting is created in front of the subject’s eyes due to the design of the body (1) of the non-contact pupillometer (namely, the enclosing surfaces of the sides (16) and the visor (1a)) and two IR LEDs (9) that constantly illuminate the right infrared range and left eyes respectively. Such background illumination during the study provides high measurement accuracy.

A continuously burning red LED (10) informs about the correct non-contact positioning, and also initiates the examination stage, provided that the subject sees the outlines of the eyes on the location indicator (8).

With the constant operation of the red LED (10) and IR-illuminating LEDs (9), the stage of the study of the functional state of the body is carried out, which consists in measuring the readings in three successively changing modes: adaptation, load and recovery, see Fig. 5.

Adaptation - the operating mode of the claimed non-contact pupillometer from the moment the red LED (10) turns on until the white light source (11) turns on. In this mode, the pupils of the person adapt to the physiological conditions of background lighting. The duration of the adaptation mode is on average 1 s.

Load - operation mode when the white light source is on (11). In this mode, the pupils respond to the stimulus. The duration of the load mode is on average 2 s.

Recovery - the operating mode of the declared non-contact pupillometer from the moment the white light source (11) is turned off until the red LED (10) blinks. In this mode, the pupils of a person adapt to the previous condition of background lighting (similar to the adaptation mode). The average recovery time is 3 s.

In all three modes, the readings of background illumination, human body temperature, and pupil reaction of the eye are measured non-contactly, continuously, and simultaneously.

Background illumination is measured using an ambient light sensor (12). Measurement of body temperature is carried out using a temperature sensor (5). The measurement of the pupillary reaction of the eye is recorded by the camera (6).

A blinking red LED (10) indicates the end of the examination phase and the beginning of the final stage.

At the beginning of the conclusion stage, they are entered into the PC database (13) under the identification code of the surveyed measurements, which were performed during adaptation, load, and recovery. Next, the processing of measurements and analysis of the data obtained at the research stage is performed.

For measurements of the pupil reaction, each image frame is processed in digital form (in pixels) and a statistical graph is used to construct a graph of the change in pupil area over time, depending on the lighting, see Fig. 5. Then at least the following parameters are calculated, see FIG. 6.

The latent time of the pupil’s reaction to the white light source (Tlat1) is calculated as the time from the moment the white light is turned on until the graph crosses the value (0.95) b, where b is the pupil area until the white light comes on.

The latent reaction time of the pupil to turn off the white light source (Tlat2) is calculated as the time from turning off the white light source until the graph crosses the value (1.05) a, where a is the steady-state area of the pupil when the white light source is on.

The angle of reaction of the pupil to the inclusion of a white light source (F1) - the tangent of this angle is used in the calculations (the ratio of the change in the area of the pupil to the duration of the reaction). The difference between (0.95) b and (1.05) a is used as a change in area. The duration of the reaction is the difference between the times the graph intersects the values of (0.95) b and (1.05) a.

The angle of reaction of the pupil to turn off the white light source (F2) - its tangent is used in the calculations. The difference between (0.95) s and (1.05) a is used as a change in area. Reaction time - the difference between the times the graph intersects the values of (0.95) s and (1.05) a.

Reaction coefficient (AmplRatio) - the ratio of the value (0.95) b to the value (1.05) a.

The average pupil area before the reaction (Average) - the average value of the pupil area in the interval of adaptation of the eye. It is calculated as the sum of all values divided by their number.

At least five studies form the individual standards of the subject, which are entered into the database in the form of a table. For each value Tlat1, Tlat2, F1, F2, AmplRatio, Average, the minimum and maximum values are selected, which are entered into the table with a tolerance of 10%.

The results of all studies are accumulated in the database under the personal identification code of the subject, which allows you to clarify the calculation of individual norms for the previously selected measurements.

In a second study, measurements are taken once, after which the parameters of the pupil’s reaction of the subject are automatically compared with his own individual standards with the issuance of an epicrisis of the functional state of the subject’s body. Epicrisis describes the nature of deviations from the norm.

The duration of one non-contact screening diagnosis of the functional state of the body with the issuance of conclusions takes less than 1 minute.

The reliability of the implementation of the result is confirmed by the manufacture and testing of a prototype.

The use of a non-contact pupillometer for screening diagnostics of the functional state of an organism implies the presence of one qualified health worker (for example, a medical assistant) for an unlimited number of devices in one room. For the first time, the health worker provides instruction, and then screening diagnostics (for example, included in the pre-shift examination) is automatic. If the testimony of the subject recorded results exceeding the norm, then either repeat the procedure again after 15 minutes or the subject undergoes an individual examination by a health worker.

Due to the automated non-contact method of screening diagnostics, high measurement accuracy, laboriousness, as well as the short time of the entire procedure and the issuance of an epicrisis, the invention will find wide application in at least the following areas:

- in narcology for the diagnosis of drug intoxication;

- in medicine for professional and routine medical examinations, psychiatric examinations;

- in production conditions for express diagnostics before and after the working day (shift) of the state of health of operators of critical industries, drivers, etc., whose professional activities are associated with the risk of technological disasters and the safety of the population;

- in judicial activities to study the reliability of the testimony of suspects, witnesses, victims.

Example 1:

Surveyed Ivanov I.I., 40 years old, miner, work experience 9 years, pre-shift / post-shift medical examinations were performed on the declared non-contact pupillometer for screening diagnostics of the functional state of the body.

Before the work shift, the identification code of Ivanov II is registered in the PC database, under which information on his pupil reactions will be stored in the future. Next, non-contact screening diagnostics is carried out at least five times according to the method described above and the individual norms of Ivanov I.I. are formed, see FIG. 7.

After a work shift with a non-contact pupillometer, a repeated screening diagnosis is carried out (once), the results (see Fig. 8) of which, after a work shift, are automatically compared with individual standards.

Epicrisis delivery is a “weakened reaction”.

Further, the health care provider should interpret the conclusion as a signal of a deviation from the norm, and in particular as a poisoning by an employee's hydrogen sulfide / carbon monoxide gas (which is confirmed on an individual basis). Then they conduct an unscheduled check of working conditions, in case of confirmation of the conclusion, the organization takes actions to eliminate the causes of the accident and provide assistance to the victims.

Example 2:

Surveyed Ivanov I.I., 40 years old, miner, work experience 9 years, held a morning pre-shift medical examination according to the above method with previously formed individual norms (Fig. 7). The results of contactless screening diagnostics are presented in FIG. 9.

Epicrisis delivery is “miosis”.

Further, the health care provider should interpret the conclusion as a signal of a deviation from the norm, and in particular as a drug intoxication of the employee (which is confirmed by an individual examination). After that, measures are taken to ban access to work.

Claims (11)

1. Non-contact pupillometer for screening diagnostics of the functional state of the body, including
case (1), holder (2), emitter (3), receiver (4), temperature sensor (5), camera (6), casing (7), position indicator (8), two infrared (IR) LEDs (9 ), a red LED (10), a white light source (11), a light sensor (12), and a computer with software (13), while
the housing (1) is made of complex shape, which can conditionally be divided into two surfaces forming (1a) the visor and (16) the enclosing sides;
the front end side of the visor of the housing (1.1) has a concave shape, that is, in the plan it is represented by an arc, in the center of which a temperature sensor (5) is installed, and the emitter (3) and receiver (4) are symmetrically placed on the edges, so that the light flux of the emitter ( 3) hit directly on the receiver (4);
the emitter (3) is represented by a photoelectric sensor generating a light flux;
the receiver (4) is represented by a photoelectric sensor receiving a light flux from the emitter (3);
the temperature sensor (5) is represented by an infrared thermometer that provides non-contact temperature measurement;
in the inner part of the enclosing sides of the case (1.2), in the center there is a camera (6) in the casing (7) and a position indicator (8), and two IR LEDs (9) are mounted opposite the camera (6) on the sides;
the casing (7) is made of a material that can evenly distribute light;
the position indicator (8) is located above the camera and is made of material, the surface of the profile side of which is reflective, with a degree of clarity sufficient to reflect the contours of the eyes;
two IR LEDs (9) operate in the infrared range, while performing the function of continuous continuous illumination of the right and left eye, respectively;
in the upper part of the housing (1) there is a light sensor (12);
on the back wall of the casing (7) behind the camera (6) there is a red LED (10) and a white light source (11);
when the luminous flux is blocked from the emitter (3) to the receiver (4), a red LED (10) is activated;
the enclosing sides of the housing (16) together with the visor (1a), as well as with two IR LEDs (9) and a light sensor (12) create and measure the background lighting condition.
2. A non-contact pupillometer for screening diagnostics of the functional state of the body according to claim 1, characterized in that the camera (6) provides registration of the pupil image in the infrared spectrum, while the frame rate should be at least 60 frames per second (60 fps), and optical resolution of at least 1.31 MPix.
3. A non-contact pupillometer for screening diagnostics of the functional state of an organism according to claim 1, characterized in that the light sensor (12) is represented by a luxometer.
4. A non-contact pupillometer for screening diagnostics of the functional state of an organism according to claim 1, characterized in that the casing (7) is made larger than the camera (6), while the camera lens (6a) is located outside the casing.
5. A non-contact pupillometer for screening diagnostics of the functional state of the body according to claim 1, characterized in that the casing (7) is made of frosted plexiglass.
6. A non-contact pupillometer for screening diagnostics of the functional state of an organism according to claim 1, characterized in that the position indicator (8) is a rectangular plate with a width equal to the width of the casing (7).
7. A non-contact pupillometer for screening diagnostics of the functional state of an organism according to claim 1, characterized in that the holder (2) can be made in the form of a tripod or stand, or anchors.
8. A non-contact method for screening diagnostics of the functional state of an organism using the device according to claim 1, including a pre-investigation stage, a research stage and a final stage, wherein
at the stage of the pre-investigation, the following is carried out: registration of the identification code of the subject, under which information is further stored; positioning the subject and creating background lighting, for this the subject, with the constant operation of two IR LEDs (10), without touching the surface of the case (1) and seeing the reflection of his eyes on the position indicator (8), brings his head closer to the front end side of the visor of the case ( 1.1) until it blocks the path of the beam from the emitter (3) to the receiver (4), thereby activating the operation of the red LED (10);
at the research stage, with the constant operation of the red LED (10) and the IR LEDs illuminating the eyes (9), a non-contact continuous simultaneous measurement of background illumination, human body temperature and pupil reaction of the eye is carried out in three successively interchangeable modes: adaptation, load and recovery; the adaptation mode lasts from the moment the red LED (10) is turned on until the white light source (11) is turned on; load mode is characterized by the operation of the included white light source (11); recovery mode lasts from the moment the white light source (11) is turned off until the red LED (10) blinks;
at the conclusion stage, the PC (13) is entered into the database under the identification code of the surveyed measurement;
performing processing and analysis of measurements; at the same time, for measuring the pupil reaction, each frame of the image is digitally processed by pixels and, by statistical processing, a graph of the change in the area of the pupil in time is plotted, depending on the lighting;
then, at least the following parameters are calculated: latent pupil reaction time to a white light source (Tlat1), latent pupil reaction time to turn off a white light source (Tlat2), pupil reaction angle to turn on a white light source (F1), reaction angle the pupil to turn off the white light source (F2), the reaction coefficient (AmplRatio), the average pupil area before the reaction (Average),
wherein
latent pupil reaction time to a white light source (Tlat1) is calculated as the time from the moment the white light is turned on until the graph crosses the value (0.95) b, where b is the pupil area value until the white light is turned on;
latent pupil reaction time to turn off the white light source (Tlat2) is calculated as the time from turning off the white light source until the graph crosses the value (1.05) a, where a is the steady-state pupil area when the white light source is on;
the angle of reaction of the pupil to the inclusion of a white light source (F1) is calculated as the tangent of this angle, that is, it is calculated as the ratio of the change in the pupil area to the duration of the reaction, while the difference between (0.95) b and (1.05) is used as the change in area a, the duration of the reaction as the difference between the times the graph intersects the values of (0.95) b and (1.05) a;
the angle of the pupil’s reaction to turning off the white light source (F2) is calculated as the tangent of this angle, that is, it is calculated as the ratio of the change in the pupil’s area to the duration of the reaction, and the difference between (0.95) s and (1.05) is used as the change in area a, the duration of the reaction as the difference between the times the graph intersects the values of (0.95) s and (1.05) a;
the reaction coefficient (AmplRatio) is calculated as the ratio of the value of (0.95) b to the value of (1.05) a;
the average pupil area before the start of the reaction (Average) is calculated as the average pupil area on the eye adaptation interval, that is, as the sum of all values divided by their number;
further, at least five studies are carried out the formation of individual norms of the subject, in which for each value Tlat1, Tlat2, F1, F2, AmplRatio, Average, the minimum and maximum values are determined with a tolerance of 10%;
during the second study, an automatic comparison of the calculated parameters of the pupil’s reaction of the subject with his own individual standards is performed with the issuance of an epicrisis of the functional state of the body.
9. A non-contact method for screening diagnostics of the functional state of an organism according to claim 8, characterized in that a continuously burning red LED (10) informs the test subject about the start of the research phase, a blinking LED (10) informs the test subject about the end of the test phase.
10. A non-contact method for screening diagnostics of the functional state of an organism according to claim 8, characterized in that the duration of the adaptation mode is on average 1 s, the duration of the load mode is on average 2 s, and the duration of the recovery mode is on average 3 s.
11. A non-contact method for screening diagnostics of the functional state of an organism according to claim 8, characterized in that the epicrisis describes the nature of deviations from the norm.
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