RU2595003C1 - Dental floss with vegetable pigment - Google Patents

Abstract

FIELD: medical equipment.

SUBSTANCE: invention relates to medical equipment and is applicable in dentistry, for daily dental care, for removing of food debris from interdental space and dental deposit, for prevention of gingivitis. Dental floss consists of twisted or not twisted cellulose diacetate threads containing antimicrobial additive-lycopene, at the following component ratio, wt. %: cellulose diacetate 95-99; lycopene 1-5 %.

EFFECT: invention allows to increase the therapeutic and preventive effect on pathogenic microflora of the oral cavity.

1 cl, 1 tbl

Description

The invention relates to medicine, and specifically to dentistry, in particular to dental floss for cleaning interdental spaces.

Dental floss is used in daily dental care to remove food debris from the interdental space and plaque to prevent gingivitis and a number of other diseases of the oral cavity.

Known dental floss based on polyamide with additives, consisting of a core - twisted or untwisted polyamide filament and shell based on copolyamide caprolactam with a salt of hexamethylenediamine and adipic acid containing an antimicrobial additive - sanguirytrin, in the following ratio of components, wt. %: polyamide twisted or untwisted yarn 75-85, copolyamide 8.25-15, sanguirythrin 6.75-10 [RU No. 2020896 C1, IPC A61C 15/04, publ. 1994].

The disadvantages of this thread are the lack of specific selective activity against pathogenic microflora, which causes gingivitis and a number of other diseases, the presence of side effects caused by the drug sanguirytrin (allergic reactions, bitter aftertaste, etc.).

The technical result of the claimed invention is to increase the therapeutic and prophylactic effect on the pathogenic microflora of the oral cavity and reduce specific unpleasant taste sensations from the antiseptic drugs used in the prototypes, increase activity against pathogenic microflora and obtain a therapeutic effect in terms of preventing gingivitis and a number of other diseases of the oral cavity.

The specified technical result is achieved in that the dental floss based on cellulose diacetate with additives consists of twisted or untwisted cellulose diacetate containing biologically active additive - lycopene, in the following ratio, wt. %: cellulose diacetate twisted or untwisted thread 95-99, lycopene 1-5%. As a core, use twisted cellulose diacetate produced in accordance with GOST 26300-84, or untwisted cellulose diacetate produced in accordance with GOST 26300-84. The thread is used with a linear density of 60-90 tex, depending on the distance between the teeth.

Lycopene is a plant carotenoid pigment obtained both by extraction from plants and by synthesis. Lycopene has an antioxidant effect, exhibits biological activity against pathogenic microflora, causing diseases of the oral cavity, in particular gingivitis (patent 2515313, publ. 05/10/2014, bull. No. 13).

The lycopene content in the yarn of more than 5% is impractical, since this content is determined by the solubility of lycopene and reduce the physicomechanical properties of the yarn, as well as the cost of the yarn economically, and the pigment content below 1% does not give a tangible therapeutic and preventive effect.

Dental floss is obtained as follows. Cellulose diacetate is dissolved in a binary solvent, acetone-water, in a ratio of 1: 9, while the plant pigment lycopene is introduced in a highly dispersed state into the polymer composition. From the resulting mass in a dry manner, cellulose diacetate is formed. The finished yarn with a linear density of 60-90 tex is obtained by crushing the formed fibers. If desired, a low degree of torsion (about 60 torsions per meter) can be communicated to maintain maximum contact surface and at the same time increase the strength of the thread. The prophylactic and therapeutic effect of different types of dental floss is determined by studying the activity of acid-forming microflora on the surface of the teeth, expressed through pH readings (maximum change in amplitude (A), pH values Δ _A ), and also by the time of restoration of the initial pH level (τ).

Example 1. Monofilament with a linear density of 6.7 tex, of which twisted cellulose diacetate consists of dental floss, are formed from a polymer composition (patent 2515313, publ. 05/10/2014, bull. No. 13) by the dry method. Then carry out the crushing and torsion by standard methods. The thread contains 1 wt. % biologically active pigment - lycopene. Physico-mechanical properties of dental floss and the effectiveness of its use are presented in table 1.

Example 2. Monofilament with a linear density of 6.7 tex, of which twisted cellulose diacetate consists of dental floss, are formed from a polymer composition (patent 2515313, publ. 05/10/2014, bull. No. 13) by the dry method. Then carry out the crushing and torsion by standard methods. The thread contains 2 wt. % biologically active pigment - lycopene. Physico-mechanical properties of dental floss and the effectiveness of its use are presented in table 1.

Example 3. Monofilament with a linear density of 6.7 tex of which twisted cellulose diacetate consists of dental floss, are formed from a polymer composition (patent 2515313, publ. 05/10/2014, bull. No. 13) by the dry method. Then carry out the crushing and torsion by standard methods. The thread contains 3 wt. % biologically active pigment - lycopene. Physico-mechanical properties of dental floss and the effectiveness of its use are presented in table 1.

Example 4. Monofilament with a linear density of 6.7 tex, of which twisted cellulose diacetate consists of dental floss, are formed from a polymer composition (patent 2515313, publ. 05/10/2014, bull. No. 13) by the dry method. Then carry out the crushing and torsion by standard methods. The thread contains 4 wt. % biologically active pigment - lycopene. Physico-mechanical properties of dental floss and the effectiveness of its use are presented in table 1.

Example 5. Monofilament with a linear density of 6.7 tex, of which twisted cellulose diacetate consists of dental floss, are formed from a polymer composition (patent 2515313, publ. 05/10/2014, bull. No. 13) by the dry method. Then carry out the crushing and torsion by standard methods. The thread contains 5 wt. % biologically active pigment - lycopene. Physico-mechanical properties of dental floss and the effectiveness of its use are presented in table 1.

According to the table, the claimed dental floss compared with the prototype allows you to increase the selective effect on the pathogenic microflora of the oral cavity through flossing (brushing), because it has a pronounced antimicrobial activity. In studies using the meat-peptone agar method (MPA) (in vitro), the growth inhibition radius of the conditionally pathogenic strain of Staphylococcus aurius (the main causative agent of gingivitis) is 7–9 mm, while in the prototype, the growth culture growth inhibition radius is 6 mm. Also, the change in the amplitude of the pH of the interdental spaces (MW) Δ _A before and after flossing for the inventive filaments is 0.3-0.4, and for the prototype 0.3, the initial pH level of the inventive filament is not restored 1 hour after cleaning. In addition, the bioactive additive lycopene does not change the taste in the oral cavity, does not cause allergic reactions.

Claims (1)

Dental floss, characterized in that it consists of twisted or untwisted cellulose diacetate containing an antimicrobial additive - lycopene, in the following ratio, wt. %:
Cellulose diacetate 95-99 Lycopene 1-5