RU2550508C2 - Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета - Google Patents

Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета Download PDF

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RU2550508C2
RU2550508C2 RU2012112471/04A RU2012112471A RU2550508C2 RU 2550508 C2 RU2550508 C2 RU 2550508C2 RU 2012112471/04 A RU2012112471/04 A RU 2012112471/04A RU 2012112471 A RU2012112471 A RU 2012112471A RU 2550508 C2 RU2550508 C2 RU 2550508C2
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alkyl
group
pharmaceutically acceptable
substituted
compounds
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RU2012112471/04A
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RU2012112471A (ru
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Тесфайе Бифту
Пин Чэнь
Даньцин ФЭН
Сяося ЦЯНЬ
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Мерк Шарп И Доум Корп.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/41621,2-Diazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2012112471/04A 2009-09-02 2010-08-23 Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета RU2550508C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23924209P 2009-09-02 2009-09-02
US61/239,242 2009-09-02
US26227809P 2009-11-18 2009-11-18
US61/262,278 2009-11-18
PCT/US2010/046270 WO2011028455A1 (en) 2009-09-02 2010-08-23 Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes

Publications (2)

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RU2012112471A RU2012112471A (ru) 2013-10-10
RU2550508C2 true RU2550508C2 (ru) 2015-05-10

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RU2012112471/04A RU2550508C2 (ru) 2009-09-02 2010-08-23 Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-iv для лечения или предупреждения диабета

Country Status (12)

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US (1) US8455533B2 (enEXAMPLES)
EP (1) EP2473047B1 (enEXAMPLES)
JP (1) JP5734981B2 (enEXAMPLES)
KR (1) KR20120092096A (enEXAMPLES)
CN (1) CN102595897A (enEXAMPLES)
AU (1) AU2010289871B2 (enEXAMPLES)
BR (1) BR112012004335A8 (enEXAMPLES)
CA (1) CA2771352A1 (enEXAMPLES)
IN (1) IN2012DN00721A (enEXAMPLES)
MX (1) MX2012002633A (enEXAMPLES)
RU (1) RU2550508C2 (enEXAMPLES)
WO (1) WO2011028455A1 (enEXAMPLES)

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RU2780322C2 (ru) * 2017-05-31 2022-09-21 Кемосентрикс, Инк. 5-5 КОНДЕНСИРОВАННЫЕ КОЛЬЦА КАК ИНГИБИТОРЫ С5а
US11773091B2 (en) 2017-05-31 2023-10-03 Chemocentryx, Inc. 6-5 fused rings as C5a inhibitors
US12268675B2 (en) 2017-12-22 2025-04-08 Chemocentryx, Inc. Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors

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US8691832B2 (en) 2010-12-06 2014-04-08 Merck Sharp & Dohme Corp. Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
ES2652662T3 (es) 2011-02-25 2018-02-05 Merck Sharp & Dohme Corp. Novedosos derivados de azabencimidazol cíclicos útiles como agentes antidiabéticos
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KR20140034861A (ko) 2011-06-29 2014-03-20 머크 샤프 앤드 돔 코포레이션 디펩티딜 펩티다제-iv 억제제의 신규한 결정질 형태
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WO2013122920A1 (en) 2012-02-17 2013-08-22 Merck Sharp & Dohme Corp. Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
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WO2014018355A1 (en) * 2012-07-23 2014-01-30 Merck Sharp & Dohme Corp. Treating diabetes with dipeptidyl peptidase-iv inhibitors
TWI500613B (zh) 2012-10-17 2015-09-21 Cadila Healthcare Ltd 新穎之雜環化合物
CN105085528A (zh) * 2014-05-15 2015-11-25 成都贝斯凯瑞生物科技有限公司 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物
CN105518008B (zh) 2014-06-17 2018-03-27 海思科医药集团股份有限公司 氨基吡喃环衍生物及其组合物和应用
US9862725B2 (en) 2014-07-21 2018-01-09 Merck Sharp & Dohme Corp. Process for preparing chiral dipeptidyl peptidase-IV inhibitors
CN105985357A (zh) * 2015-02-12 2016-10-05 北京赛林泰医药技术有限公司 取代的氨基六元饱和杂脂环类长效dpp-iv抑制剂
TWI681962B (zh) * 2015-08-26 2020-01-11 大陸商四川海思科製藥有限公司 胺基六員環類衍生物及其在醫藥上的應用
CN107459501B (zh) * 2017-08-22 2020-06-09 钟桂发 一种奥格列汀的手性中间体的制备方法
JP7150862B2 (ja) * 2018-02-06 2022-10-11 スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド アミノピラン誘導体の組成物
US11608336B2 (en) 2018-04-02 2023-03-21 Chemocentryx, Inc. Prodrugs of fused-bicyclic C5aR antagonists
KR102131359B1 (ko) * 2018-09-07 2020-07-07 오토텔릭바이오 주식회사 안정성이 향상된 의약 조성물

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WO2011028455A1 (en) 2011-03-10
AU2010289871A1 (en) 2012-04-26
EP2473047A1 (en) 2012-07-11
JP2013503864A (ja) 2013-02-04
MX2012002633A (es) 2012-04-20
US20120149734A1 (en) 2012-06-14
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BR112012004335A8 (pt) 2016-06-21
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CN102595897A (zh) 2012-07-18
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RU2012112471A (ru) 2013-10-10
BR112012004335A2 (pt) 2015-09-08
IN2012DN00721A (enEXAMPLES) 2015-06-19
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EP2473047B1 (en) 2014-08-13

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