RU2445986C1 - Method of treating tensions of extra-articular ligaments and tendons - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely restorative medicine and may be used for treating tensions of extra-articular ligaments and tendons. A method involves injection introduction into an affected region of a solution of the dispersed biological material Alloplant - a stimulator of nerve structure regeneration made of great peripheral nerves of the allogenic donor material by preparation with reagents for the purpose of membranolysis and drying in a lyophiliser and powdering followed by radiation sterilisation. The biological material is dissolved in a local anaesthetic in the relation of 250 mg of the biological material per 10 ml of the solution. The injections are perifocal in 1-6 points.

EFFECT: invention provides higher clinical effectiveness in tensions of ligaments and tendons ensured by accelerated restorative processes, early reinnervation of affected tissues.

Description

The invention relates to medicine, namely to reconstructive medicine, and can be used to treat extra-articular sprains and tendons.

It is known that the early recovery of a patient with any trauma depends on an adequate analgesia. The use of narcotic analgesics and epidural anesthesia is limited and unreasonable for injuries such as sprains and tendons. According to (Zykov O.V. Optimization of tissue regeneration under conditions of prolonged local anesthesia using allogeneic biomaterial (experimental-morphological and clinical research): abstract of diss. ... candidate of medical sciences. - Ufa, 2006. - 23 p.) promising is the development of methods for prolonging local anesthesia with the minimum required doses of injected drugs.

Currently, orthopedic traumatologists have developed methods for introducing a local anesthetic into the tissue of a damaged tendon or ligament. At the same time, primary and secondary therapy of tendon and ligament sprains is distinguished. Secondary therapy, in particular, includes the method of injection of various pharmacological preparations (S. A. Makarov, S. A. Sergienko. Sprains, tendons and muscles (Institute of Rheumatology RAMS, Moscow). // Medical Encyclopedia "Medina". / Electronic resource: http://medinfa.ru/article/106/118767/, 2005-2010).

Analogues of the method are local injections of various non-steroidal and steroidal anti-inflammatory drugs in the area of tendon stretching (L. Zulkarneev. Errors and complications in the treatment of local glucocorticosteroid injections: Methodological recommendations. - Kazan, 1973 - 18 p.). The above methods have the following disadvantages: a short analgesic effect, depending on the rate of resorption of the anesthetic from the tissues (Zykov O.V. Optimization of tissue regeneration under conditions of prolonged local anesthesia using allogeneic biomaterial: abstract of dissertation ... candidate of medical science. - Ufa, 2006. - 23 p.). Ligamentous ruptures in the area of hormone administration are also possible due to increased collagen resorption, which also limits their use (S. A. Makarov, S. A. Sergienko. Sprains, tendons and muscles (Institute of Rheumatology RAMS, Moscow). // Medical Encyclopedia of Medina. / Electronic resource: http://medinfa.ru/article/106/118767/, 2005-2010).

The prototype of the invention is a method of stimulating the reparative regeneration of tendons and ligaments by injecting into the damaged area a dispersed Alloplant biomaterial - regeneration stimulator (RF patent No. 2284768, IPC АВВ 17/00, publ. 10.10.2006). The disadvantage of this method is the lack of the effect of prolonged analgesia, which prevents the early recovery of patients with stretch tendons of the II degree.

The objective of the invention is to increase the effectiveness of the treatment of sprains and tendons by accelerating recovery processes, early reinnervation of damaged tissues.

The problem is solved by the method of treating extra-articular ligaments and tendons, including the injection of a solution of dispersed Alloplant biomaterial into the damaged area, in which, unlike the prototype, Alloplant is used as a biomaterial, a stimulator of regeneration of nerve structures made from large peripheral nerves of allogeneic donor material by processing them reagents for the purpose of membranolysis, drying in a lyophilizer and grinding to a powder state, followed by s radiation sterilization, wherein the biomaterial is diluted in a solution of a local anesthetic at a ratio of 250 mg per 10 ml biomaterial solution and the injection performed in perifocal 1-6 points.

The proposed method ensures the achievement of a technical result due to the following.

The effect of prolonged analgesia contributes to the early restoration of the function of the damaged tendon (ligament) due to the reduction of the protective regime for the damaged limb and the early attachment of the “load factor”. The latter, as is known, plays an important role in the regeneration of the structures of the musculoskeletal system. The neurotrophic factor in the dispersed biomaterial stimulates the regeneration of nerve structures within the tendon or ligament. Early restoration of innervation reduces the duration of the pain syndrome and acts as a factor in the regeneration of the tendon or ligament. It is known that early reinnervation of a damaged organ or tissue contributes to the optimization of the mechanisms of reparative regeneration (Liozner L.D., 1963).

The method is as follows. For the manufacture of a biomaterial-stimulator of the regeneration of nerve structures, allogeneic donor peripheral nerves are used, which are processed using Alloplant technology (RF patent No. 2189257, IPC A61L 27/00, published on September 20, 2002). The material treated with the reagents for the purpose of membranolysis is dried and crushed to obtain a dispersed form. For injection into the injured area of the tendon or ligament, a solution is prepared: 250 mg of biomaterial and 10 ml of a local anesthetic solution (lidocaine 1-2%, ultracain, etc.). The resulting solution produce perifocal chipping of the injury at 1-6 points. The resulting solution can also be used to perform long-term conduction anesthesia, as well as to perform blockades in case of pain against the background of damage to large peripheral nerves and plexuses.

According to the proposed method, 9 patients with sprain of tendons and 10 patients with sprain of extraarticular ligaments were treated. In all patients, early restoration of the function of the damaged tendon or ligament was observed.

Thus, the claimed invention allows to increase the effectiveness of the treatment of sprains and tendons by accelerating recovery processes, due to the early reinnervation of damaged tissues

Claims (1)

A method for treating extra-articular ligaments and tendons, including injecting a solution of dispersed Alloplant biomaterial into the damaged area, characterized in that Alloplant is used as a biomaterial - a stimulator of regeneration of nerve structures made from large peripheral nerves of allogeneic donor material by treating them with reagents for the purpose of membranolysis, drying in a lyophilizer and grinding to a powder state, followed by radiation sterilization, and bio Container material diluted in a solution of a local anesthetic at a ratio of 250 mg per 10 ml biomaterial solution and the injection performed in perifocal 1-6 points.