RU2181587C1 - Method to prevent and treat stresses with aurol (thyrosol-c) preparation in farm animals - Google Patents

Abstract

FIELD: veterinary science. SUBSTANCE: animals are perorally or by injections introduced with aurol (thyrosol-C) preparation as 1+ACU- aqueous solution at the dosage of 4-15 ml once or repeatedly. Calves are fed with aurol (thyrosol-C) per 10 ml daily for 5 d before and 5 d after regrouping (transfer from dispensary to collection group) or injected subcutaneously per 5 ml 14 and 7 d before regrouping. Pigs are fed with aurol (thyrosol-C) as 10 ml inwards once daily for 7 d before weaning and transfer to raising groups and for 7 d after forming the raising groups or injected subcutaneously per 4 ml, twice at 5-d-long interval, 10 d before weaning and at the day of transfer into raising groups before the onset of regrouping. Poultry at vaccination are fed with aurol (thyrosol-C) at 15 mg/kg body weight for 3 d. EFFECT: increased safety under conditions of technological stresses, higher body weight gains in farm animals. 5 cl, 4 tbl

Description

 The invention relates to the field of veterinary medicine, in particular to methods for the prevention and treatment of animal stress.

 In veterinary medicine, Eleutherococcus preparations and Rhodiola rosea extract, which have the same properties, are used as adaptogens. Both of these drugs are prescribed for the correction of technological stresses for 2-3 weeks (see Pharmacology. - M .: Kolos, 1997.- S. 382).

 The closest solution adopted for the prototype is the drug and its use for the prevention and treatment of animal stress, in which propovit is administered as adaptogens once or for 7-14 days at a dose of 1-10 mg / kg body weight (see Buzlama BC The general resistance of animals to stress and its regulation by adaptogens. - Reports of the Russian Academy of Agricultural Sciences, 1996, 1. - P. 36 - 38).

 The disadvantages of the drug propovit include its high cost.

 The technical problem to which the claimed invention is directed is to obtain a more pronounced immune response of the animal organism to stresses caused by technological reasons for the content and expansion of the range of adaptogens.

 The essence of the invention lies in the fact that in the known method for the prevention and treatment of animal stress, including the introduction of animals orally or by injection of adaptogens, according to the invention, aurool (tyrosol-C) is used as an adaptogen in the form of a 1% aqueous solution at a dose of 4- 15 ml once or repeatedly.

 The essence of the invention also lies in the fact that the calves are fed aurool (tyrosol-C) in 10 ml daily for 5 days before and 5 days after regrouping (transfer from a dispensary to a typesetting group). The results are shown in table. 1.

 The essence of the invention also lies in the fact that piglets are fed aurool (tyrosol-C) at a dose of 10 ml orally once a day for 7 days before weaning from sows and transferring them to rearing groups and within 7 days after the formation of rearing groups. The results are shown in table. 2.

 The essence of the invention also lies in the fact that piglets Aurol (tyrosol-C) is injected subcutaneously in 4 ml for 10 days, twice with an interval of 5 days, before weaning from sows and on the day of transfer to nursing groups before regrouping. The results are shown in table. 2.

 The essence of the invention also lies in the fact that during vaccination, the bird is fed aurool (tyrosol-C) at a dose of 15 mg per 1 kg of live weight for 3 days. The results are shown in table. 4.

 Based on clinical observations and laboratory results, an increase in the indicators of nonspecific resistance of young cattle when using aurool (tyrosol-C) in the form of a 1% aqueous solution at a dose of 10 ml per day for 5 days before and 5 days after regrouping was established. animals and in the form of a 10% aqueous solution in a dose of 5 ml subcutaneously for 14 and 7 days before the rearrangement of animals.

 Based on the results of studies on pigs, an increase in the indicators of nonspecific resistance of the body was established with the introduction of aurool in the form of a 1% aqueous solution at a dose of 10 ml orally 7 days before and 7 days after weaning from sows and transfer to rearing groups and at a dose of 4 ml subcutaneously 10 days before weaning from the sow and on the day of transfer to rearing groups.

 It was established that the gain in the experimental group of goslings began on the third day after the rearrangement. In the control group - a day later. Over the entire period of feeding, the gain in the experimental group was 2 times higher compared to the control group. The safety of birds in the experimental and control groups was also significantly different: before the rearrangement, the safety of birds in the groups was equal; on the first day after regrouping, the safety of birds in the control group decreased by 16.1%, in the experimental group - only 4.1%; on the sixth day, the safety of the birds in the experimental group was restored to the technologically permissible norm; in the control, the stability was stabilized only by the 10th day (Table 3).

 Aurole (tyrosol-S) is a complete structural analogue of the active substance of the pink radiola. Aurole (tyrosol-C) is synthesized by hydroxyalkylation of 2,6-di-tert. butylphenol and subsequent di-tert.butylation (A.P. Krysin, V. S. Kobrin. Method for the production of 4- (hydroxyalkyl) phenols. Patent of the Russian Federation 2063395 of July 18, 1996, Bull. 19).

 A study of the effect of aurool (tyrosol-C) on the level of the immune response of birds during vaccination was performed on hens of 140 days of age, in which the level of AHA was determined before vaccination. A 4-valent virus vaccine was used according to the vaccination program for the parental forms of chicken of the meat direction of Lomann meat productivity. The vaccine contained antigens of the Newcastle disease virus (NB), infectious bronchitis, Gamboro disease and Reovius. The level of the immune response was monitored in the reaction of delayed hemagglutination (RHCA), according to the titer of antihemagglutinins (AHA) 14 days after vaccination.

As a result of the study, it was found that the average geometric titer of AHA in the blood serum of birds of the experimental and control groups before vaccination was 2.4 ± 0.6 log ₂ , and 14 days after vaccination in the experimental - 7.9 ± 0.8 log ₂ , control - 5.2 ± 0.4 log ₂ .

 The data obtained show that the use of aurool (tyrosol-C) with intramuscular injection of the vaccine before trapping subsequently provides a more pronounced immune response, which increases the time for revaccination of birds, thereby reducing the cost of vaccination.

 To determine the effect of aurool (tyrosol-C) on the level of the bird's immune response during vaccination, a 4-valent virus vaccine was used according to the vaccination program for parental forms of chicken of the Lomann meat productivity direction. The vaccine contained antigens of the Newcastle disease virus (NB), infectious bronchitis, Gamboro disease and Reovius. The level of the immune response was monitored in the reaction of delayed hemagglutination (RHCA), according to the titer of antihemagglutinins (AHA) 14 days after vaccination.

Thus,
- the use of the drug aurool (tyrosol-C) has a stimulating effect on non-specific factors of animal immunity:
- calves during their adaptation when transferring from a calf-dispensary to a typesetting group;
- piglets in the period after weaning from sows and the formation of rearing groups;
- goslings - when catching and transporting them from the incubator to the growing workshop;
- the stimulating effect of aurool (tyrosol-C) on the increase in average daily weight gain was established:
- piglets - by 5.05-7.00%;
- goslings - ~ 2 times (10 days after regrouping);
- the use of the drug aurol (tyrosol-C) can reduce the death of birds after technological stress in the first days after rearrangement by 10-15%;
- the use of the drug aurol (tyrosol-C) allows you to increase the level of antibody response to the vaccine, which allows to increase the time of revaccination and thereby reduce the cost of vaccination.

Claims (6)

 1. A method for the prevention and treatment of animal stresses, including administering to the animals orally or by injection of adaptogens, characterized in that aurool (tyrosol-C) is used as an adaptogen in the form of a 1% aqueous solution in a dose of 4-15 ml once or repeatedly.  2. The method according to p. 1, characterized in that the calves are fed aurool (tyrosol-C) of 10 ml daily for 5 days before and 5 after rearrangement (transfer from a dispensary to a typesetting group).  3. The method according to p. 1, characterized in that the calves Aurole (tyrosol-C) is administered subcutaneously in 5 ml for 14 and 7 days before rearrangement.  4. The method according to p. 1, characterized in that the piglets are fed aurole (tyrosol-C) in a dose of 10 ml orally once a day for 7 days before weaning from sows and transferring them to rearing groups and within 7 days after formation growing groups.  5. The method according to p. 1, characterized in that the Aurol pigs (tyrosol-C) are injected subcutaneously in 4 ml per 10 days, twice with an interval of 5 days, before weaning from sows and on the day of transfer to nursing groups before regrouping.  6. The method according to p. 1 characterized in that the bird is vaccinated with aurool (tyrosol-C) at a dose of 15 mg per 1 kg of live weight for 3 days.

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