RU2164798C1 - Homeopathic medicinal agent regulating metabolic processes in animals - Google Patents

Abstract

FIELD: veterinary science, homeopathy, pharmacy. SUBSTANCE: homeopathic agent regulating metabolic processes has Lycopodium, Arsenicum and Phosphorus taken in the ratio 1:1:3, respectively, in the definite dilution of components, in parts: Lycopodium D8-1, Arsenicum D12-1 and Phosphorus D30-1. Invention can be used for treatment of animals with immuno-deficiency states and degenerative processes. EFFECT: broadened spectrum of pharmacological effect, absence of adverse symptoms and complications. 4 cl, 13 ex

Description

 The invention relates to veterinary medicine, and in particular to agents that regulate metabolic processes in the body, and can be used to treat immunodeficiency states and degenerative processes in animals.

Known means of regulating metabolic processes in animals "Katozal" (manufactured by Bayer AG, Germany), which is a complex preparation, which includes butophosphamide, cyanocobalamin, solbrol and water. Catozal has a tonic effect, has a stimulating effect on metabolic processes (protein, carbohydrate and fat), increases the body's resistance to various diseases and adverse environmental factors, promotes the growth and development of animals (Klenova I.F., Ilyukhina I.N., Pisanova L.A. “Foreign Veterinary Medicines in Russia.” 1999-2000, (handbook), M. Evers Company, 1999, p. 267.)
However, Catozal has side effects. So, due to cyanocobalamin, which is part of the preparation, it can cause allergic phenomena, nervous agitation, activates the blood coagulation system, increases the risk of thrombosis, leads to erythro- and leukocytosis, etc. In addition, Katozal is ineffective in reducing cardiac activity and inflammation of the liver parenchyma. Known homeopathic medicine "Engystole for veterinary medicine" containing Vincetoxicum hirundinaria, Cynanchum Vincetoxicum - Pflanzenasche and Sulfur with a certain dilution of the components (manufactured by Biologische Heilmittel Heel, Germany). The tool has the ability to increase immunity in viral diseases, for all diseases of viral etiology, it is the basic drug used in combination with other drugs. One of the main indications for the appointment of Engystol is a decrease in the immune reactivity of the body, which causes the chronic course of the disease and contributes to the formation of a degenerative process. The drug is prescribed for diseases of the digestive system, musculoskeletal system, dermatoses, allergic and autoimmune diseases, diseases of the central nervous system, urogenital system, respiratory tract, neoplasms (A. V. Lipin. "Veterinary workshop on homotoxicology", M., "Gothic", 1997, pp. 113-115).

The objective of the present invention is the creation of a domestic homeopathic veterinary medicine that regulates metabolic processes, which is a combined drug aimed at expanding the pharmacological spectrum of action and free from these disadvantages. The task is achieved in that the proposed homeopathic veterinary medicine that regulates metalobolic processes contains Lycopodium, Arsenicum and Phosphorus, taken in a ratio of 1: 1: 3, respectively, with a certain dilution of the components, in parts:
Lycopodium D8 - 1
Arsenicum D12 - 1
Phosphorus D30 - 3
Indications for use of the claimed funds:
- heart failure
- hepatic encephalopathy
- glomerulonephritis, chronic renal failure
- dermatitis with itching
- hyperkeratoses
- seborrhea
- allergic diseases
- chronic liver disease
- acute and chronic diarrhea, hemorrhagic diarrhea
- dyspepsia
- epilepsy
The proposed tool can be made in the form of sugar granules, tablets and injection solutions. All components included in the claimed composition are known in homeopathy and are allowed in medical and veterinary practice (Homeopathic Pharmacopoeia of Germany, 1985).

The invention is illustrated by the following example. Example:
Composition per 100 g of granules:
Lycopodium D8 - 0.2 g
Arsenicum D12 - 0.2 g
Phosphorus D30 - 0.6 g
Excipients (sugar grains according to GOST 7060-79) up to 100 g.

 Any change in the qualitative composition of the proposed tool, as well as a change in the ratio of components and their dilutions do not lead to the achievement of the claimed technical result.

 The inventive tool in the form of granules is obtained as follows. 100 g of unsaturated homeopathic granules moisturize 1 g of ethyl alcohol 45% in a closed vessel, then potentiated solutions of homeopathic components that are part of the complex preparation are added and dynamized for 10 minutes.

FINAL PRODUCT CHARACTERISTICS
Appearance. Homogeneous granules of regular spherical shape in white with a gray or cream shade, odorless.

Authenticity
1. 5 granules are placed in a 50 ml flask, 1 ml of a 1% hydrochloric acid solution is added and heated in a boiling bath until the granules are completely dissolved within 5 minutes. Then add 2 ml of Feling's reagent and heat in a boiling water bath for 5 minutes. The precipitate is brick red (sugar).

 2. 2 granules are dissolved in 0.5 ml of water, 0.1 ml of sodium hydroxide solution, 0.1 ml of cobalt nitrate solution are added; appears blue-violet staining (sugar).

 Note. Preparation of the Feling reagent according to the Global Fund 11th ed., Issue 2, p. 125. In the absence of saltnet salt, the Feling reagent is prepared as follows: about 3.5 g of recrystallized copper sulfate (GOST 4165 - 78) is dissolved in 50 ml of water, acidified with 2 drops of diluted sulfuric acid.

 The claimed tool in the form of tablets is obtained by pressing granules saturated with homeopathic dilutions. The characteristic of the final product: meets the requirements of GF X I, M., "Medicine", 1990. V.2, p. 154, the article "Tablets".

 The proposed tool in the form of injection solutions contains physiological saline as adjuvants and meets the requirements of GF X I, M., "Medicine", 1990. V.2., P. 140, article "Injectable dosage forms".

 Clinical trials were conducted on the basis of the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, the Academic Center for Veterinary Medicine (Moscow), the Veterinary Methodological Center (St. Petersburg) and the station for combating animal diseases (Eastern District of Moscow).

Clinical trials have shown the following:
- no contraindications and side effects have been identified
- interaction with other drugs is not detected
- dosage and method of application: on the recommendation of a veterinarian, depending on the diagnosis and condition of the animal
- course of treatment: on the recommendation of a veterinarian
EXAMPLES
Example 1
A Pekingese dog, 4 years old, was admitted for treatment with symptoms of generalized itching, which began to bother the animal from 2 years of age. Itching intensified with emotional arousal. Treatment with antihistamines and corticosteroids has failed. After the appointment of Liarsin, 2 grains 2 times a day, the intensity of the itching became less after 1 week. After 2 months of treatment, the dog stopped itching and became calmer. Within 6 months after the end of treatment, itching did not resume.

Example 2
After a plague, a German shepherd dog had an overgrowth of nasal mirror tissue and paw pads. The skin has changed in type of hyperkeratosis. Deep cracks in the nose were periodically bleeding. Liarsin was prescribed at a dose of 7 grains 3 times a day. After two weeks, the wounds in the affected areas were healed, after 1 month the skin of the nasal mirror and pads became more elastic. Full recovery was noted after 3.5 months.

Example 3
A dog of the Doberman Pinscher breed, 1.5 years old, was admitted for treatment with symptoms of generalized seborrhea. Itching is absent. Treatment with high doses of vitamin A against a background of a balanced diet did not work.

 The drug Liarsin was prescribed for a long time at a dose of 7 grains 2 times a day.

 The first signs of improvement (decreased dandruff) appeared after 1 month of treatment. By 3 months, there were separate foci of peeling. By the 6th month of treatment, a stable state was achieved in which the signs of seborrhea were not expressed.

 Given the inherent nature of dry seborrhea in this patient, it is recommended to repeat Liarsin courses 1-2 times a year.

Example 4
An American Staffordshire dog with a diagnosis of atopic dermatitis was prescribed antihistamine medication that reduced the inflammatory skin reaction and itching. However, frequent exacerbation episodes required additional prescriptions. The drug Liarsin at a dose of 5 grains 4 times a day during the exacerbation and twice a day during remission. The period between exacerbations increased 2.5 times. Given the chronic form of the disease, the long-term use of the drug Liarsin is recommended.

Example 5
A collie dog at the age of 6 was admitted for treatment with symptoms of chronic vomiting, unstable stool, and general exhaustion. At the age of 8 months, she had viral hepatitis. An additional study revealed signs of degeneration of the liver parenchyma and chronic cholecystitis.

 The drug Liarsin is prescribed in an initial dose: 5 grains 4 times a day. After normalizing appetite and stool (after 2 weeks), the appointment was reduced to 2 times a day. Treatment was continued for another month and discontinued due to the absence of any manifestations of the disease. Over the 12-month observation period for the animal, no recurrence of the disease was noted.

Example 6
Acute hemorrhagic diarrhea with a lack of appetite and progressive dehydration in a dog of the Chow-Chow breed was stopped by the administration of the drug Liarsin, 5 grains every 15 minutes for 2 hours. After 6 hours, appetite appeared, signs of dehydration disappeared after 24 hours. Treatment is discontinued 48 hours after full recovery.

Example 7
The appointment of Liarsin for dyspepsia in calves leads to the restoration of digestion in them on the second day. The drug was prescribed at a dose of 10 grains 4 times a day. Additionally, no treatment was performed.

Example 8
Kotu, 11 years old, with chronic renal failure, flaccid appetite and depression, was prescribed Liarsin in a dose of 2 grains 4 times a day. After 3 days, the amount of urine removed increased, and appetite increased. After 2 weeks, the animal's reactions improved, activity increased. After a month, the drug is reduced to 2 times a day. In this mode, treatment was carried out for 4 months. During this time, clinical manifestations of renal failure were not observed. Recommended continuous use of Liarsin.

Example 9
A dog of the Rottweller breed, 9 years old, was admitted for treatment for sudden attacks of shortness of breath, which manifested themselves at night and after physical exertion. An additional examination revealed heart failure of the II degree.

 Liarsin was prescribed 7 grains 4 times a day, and during an attack - every 15 minutes. 2 days after the start of treatment, the attacks disappeared and did not resume within 1 month, after which Liarsin was prescribed at a dose of 7 grains 2 times a day for long-term therapy.

 For 4 months of monitoring the animal, seizures were noted only twice after significant physical exertion.

Example 10
Signs of encephalopathy began to progress in a cat of 12 years: drowsiness, impaired coordination. An examination revealed severe liver failure.

 8-10 days after the administration of Liarsin at a dose of 2 grains 3 times a day, the animal became more active, coordination improved, movements became more confident. By the end of the first month of treatment, behavior and motor activity returned to normal. Given the irreversibility of the degenerative processes that cause the symptoms of encephalopathy, the drug was prescribed for a long time. The animal was monitored for 5 months; its condition was stable.

Example 11
Epilepsy of guinea origin in a 4-year-old outbred dog has been monitored for a long time by the administration of anticonvulsants. After prescribing Liarsin in a dose of 5 grains 2 times a day, it was possible to increase the intervals between seizures from 1.5 to 3.5 months.

Pill example
Siberian cat, 6 years old. Within 2 years - frequent vomiting after eating. Gastroscopy revealed changes in the mucous membranes of the stomach and esophagus, characteristic of chronic catarrh. Diagnosis: chronic reflux esophagitis.

 Prescribed Liarsin IM in 1 ml per day for 1 month. Vomiting stopped a day after the start of treatment. During the observation period (6 months), vomiting was observed 2 times.

Injection Solution Example
A dog of the Schnauzer-Zverk breed, 12 years old, suffered from attacks of shortness of breath and coughing after emotional stress for a long time. Examination of the animal revealed coronary heart disease and endocardiosis.

 Liarsin was prescribed in tablets: 1/2 x 3 times a day and in injections: 1 ml subcutaneously during an attack.

 The duration of seizures immediately decreased, and the intervals between seizures increased from several hours to several days. The treatment is currently ongoing.

 Thus, the proposed tool has a wide spectrum of pharmacological action and high efficiency in the treatment of animal diseases associated with metabolic disorders.

Claims (3)

1. Homeopathic medicinal product that regulates metabolic processes in animals, based on plant materials and inorganic components, characterized in that it contains Lycopodium as plant materials, and Arsenicum and Phosphorus as inorganic components taken in a ratio of 1: 1: 3 respectively, at the next dilution of the components, including:
Lycopodium D8 - 1
Arsenicum D12 - 1
Phosphorus D30 - 3
2. Homeopathic medicine according to claim 1, characterized in that it is made in the form of granules.  3. Homeopathic medicine according to claim 1, characterized in that it is made in the form of tablets.  4. Homeopathic medicine according to claim 1, characterized in that it is made in the form of injection solutions.