RU2112500C1 - Foot balsam - Google Patents

Abstract

FIELD: medicine, in particular, cosmetology. SUBSTANCE: balsam contains biologically active additive collagenase in combination with chitosan. Balsam deodorizes foot skin and has no irritating and allergic action. EFFECT: higher epithelizing and keratolytic effect. 1 tbl

Description

 The invention relates to medicine, namely to cosmetology and relates to creams for skin care of the legs.

 The legs are under heavy load every day, they withstand the entire burden of our body, undergoing fatigue and hyperemia. Therefore, the composition of foot care creams, in addition to natural fatty components with a softening effect, often includes biologically active additives - camphor, chlorophyllin and others.

 Camphor stimulates periodic blood circulation in the skin and thus removes the feeling of fatigue [1].

 Chlorophyllin and other preparations obtained from conifers give deodorizing and wound healing properties [4].

 Sometimes antiseptic agents, for example, boric or salicylic acid, are introduced into the composition of foot creams. The latter also has a keratolytic effect [3].

 Known foot cream "Effect" containing oil from fruit seeds and almonds, distilled glycerin, cosmetic stearin, pure triethanolamine, distilled monoglycerides, glycerol monostearate, coniferous sodium chlorophyllin, vitamin F, urea, paraform, purified ethyl alcohol, rectified ethyl distilled , perfume and water [2].

 The disadvantage of the prototype is: a weak emollient and exfoliating effect on keratinized tissues of the feet, a weak antiseptic effect, the absence of antifungal activity.

 The essence of the invention lies in the fact that the proposed foot balm contains, as a biologically active additive, additionally collagenase and chitosan, which together with other components of the cream significantly enhance its therapeutic and prophylactic activity.

In addition, the balm contains: perfume oil, vegetable oils, mink fat, cosmetic stearin, triethanolamine, emulsion wax, distilled monoglycerides, anhydrous lanolin, hydroxyethylated lanolin, ethyl carbamide, camphor, chitosan, salicylic phenylate or boric acid collagenase, preservative, fragrance and drinking water, in the following ratios of components (in wt.%, taking into account alternative components):
Perfume oil or butyl stearate or isopropyl palmitate or isopropyl myristate - 3.0-5.0
Vegetable oil - 5.0-7.0
Deodorized mink fat or mink oil or chicken fat or chicken oil - 3.0-5.0
Cosmetic stearin - 0.5-2.0
Triethanolamine - 0.5-1.0
Emulsion Wax - 3.0-5.0
Distilled monoglycerides (MHD) or glycerol monostearate or DEG stearate - 3.0-5.0
Anhydrous lanolin or hydroxyethylated lanolin - Not more than 1.0
Ethyl alcohol - 3.0-5.0
Urea - 0.5-1.0
Camphor - 0.15-1.0
Boric acid or salicylic acid - 0.2-0.5
Chitosan - 0.5-1.0
Collagenase - 0.1-0.5
Phenoxyethanol - 0.5-1.0
Preservative - 0.05
Fragrance - 0.2-1.0
Drinking water - Up to 100.0
To enhance antiseptic activity, urotropin can be included in the composition in the following ratios of components, wt.%:
Perfume oil or butyl stearate, or isopropyl palmitate, or isopropyl myristate - 3.0-5.0
Vegetable oil - 5.0-7.0
Deodorized mink fat or mink oil, or chicken fat, or chicken oil - 3.0-5.0
Cosmetic stearin - 0.5-2.0
Triethanolamine - 0.5-1.0
Emulsion Wax - 3.0-5.0
Distilled monoglycerides (MHD) or glycerol monostearate or DEG stearate - 3.0-5.0
Anhydrous lanolin or hydroxyethylated lanolin - Not more than 1.0
Ethyl alcohol - 3.0-5.0
Urea - 0.5-1.0
Camphor - 0.15-1.0
Chitosan - 0.5-1.0
Salicylic acid or boric acid - 0.2-0.5
Phenoxyethanol - 0.5-1.0
Collagenase - 0.1-0.5
Preservative - 0.05
Urotropin - Not more than 0.5
Fragrance - 0.2-1.0
Drinking water - Up to 100.0
The qualitative and quantitative composition of the balm, as well as the use of chitosan, collagenase, as well as urotropin as biologically active additives, should be considered essential features of the proposal. It was the selection of an adequate base and effective dietary supplements that made it possible to create a new balm for the feet, which has a pronounced therapeutic, prophylactic and hygienic effect.

The following is a description of the raw materials that make up the balm:
Perfume oil - butyl stearate, isopropyl palmitate, isopropyl myristate - the oil components of the balm, provide a good glide cream on the skin.

 Vegetable oils - oil components of the cream, soften and nourish the skin.

 Mink fat - is used as a good emollient, quickly absorbed component that does not leave a feeling of greasy on the skin, is easily emulsified.

 Cosmetic stearin - is used as an emulsifying and structure-forming component.

 Triethanolamine - together with stearin forms a compound exhibiting good emulsifying properties.

 Emulsion wax - emulsifier for oil-water emulsions.

 Distilled monoglycerides are a structure-forming and stabilizing component in cosmetic emulsions.

 Lanolin - increases the thermal stability of the cream, softens the skin well, is quickly absorbed, and helps the skin absorb biologically active substances.

 Rectified ethyl alcohol of higher purity - used as a solvent to reduce the freezing temperature of products, to increase the effectiveness of preservatives.

 Carbomide is an emollient.

 Synthetic camphor - stimulates peripheral blood circulation, relieves fatigue, has an antiseptic, deodorizing and healing effect on the skin.

 High-molecular chitosan - is a natural polysaccharide obtained by chemical treatment of crab shells. It has anti-inflammatory and wound healing effects, stimulates the metabolism in the skin.

 Salicylic acid - an antiseptic and deodorizing agent, helps exfoliate keratinized epithelium.

 Boric acid - is used together with salicylic acid, as an antiseptic.

 Phenoxyethanol is a preservative, most effective against gram-negative bacteria.

 Collagenase - a proteolytic enzyme isolated from the liver of king crab, has a softening effect, helps exfoliate keratinized epithelium, and promotes skin renewal.

 Urotropin - has bactericidal properties.

 Fragrance - gives the cream a pleasant smell.

 Water - is the main component for the preparation of emulsion cream.

The preparation of the balm is as follows:
A prescription amount of water, triethanolamine, carbimide, boric or salicylic acid is loaded into the digester and heated to a certain temperature.

 Then pre-molten prescription amount of solid fatty raw materials is loaded: perfume and vegetable oils, mink fat, stearin, emulsion wax, distilled monoglycerides, anhydrous lanolin, hydroxyethylated lanolin and emulsify using a stirrer. Then cool the emulsion to room temperature. During the cooling process, the prescription amount of preservatives, camphor, collagenase, chitosan, urotropin, and perfumes are loaded.

 The finished cream after analysis for compliance with GOST 29189-91 is Packed in bottles.

 Balm is a homogeneous mass that does not contain impurities, from white to light cream color with a pleasant smell.

 To disclose the invention below are the results of an experimental-clinical study of the proposed balm for the legs.

 1. Research technique. The experiments were carried out on 50 sexually mature CEWA male mice weighing 20-22 g and using a standard vivarium diet. Subacute toxicity was studied as described by Gatsuro, an irritant and allergenic effect according to the Ievleva method. Determination of the morphological structure of the skin by staining with hemotoxelin-eosin and Sudan 4. Proteolytic activity was studied by measuring the amount of protein spectrophotometrically.

 To determine the proteolytic activity of the skin during the application of foot balm, 20 CEWA male mice were used, divided into two groups of ten animals. In each experimental group, the cream was applied to the shaved left side for two weeks. The control group was subjected to the same procedures without applying cream. Both groups were kept under identical conditions.

The day after the last application of the cream, the animals were killed by decapitation. Cut out experimental skin areas were immediately weighed and homogenized in Hanks medium without phenol red (HB) at the rate of 1 ml of HB per 100 mg of skin. Aliquots of the homogenate were transferred to test tubes containing a substrate and incubated for 2 hours at 37 ^° C. Bovine serum albumin and casein were used as a substrate for proteolysis. The reaction was stopped by the addition of 10% trichloroacetic acid, and then the amount of digested protein was measured.

 Clinical testing was carried out on 35 healthy people (25 women and 10 men) aged 18 to 60 years.

 The balm was applied to previously cleansed skin of the legs 1 time per day.

 In order to identify individual sensitivity before the test, all patients underwent patchwork under a closed dressing, applying the test balm for 24 hours on the inner surface of the forearm.

During clinical testing, the following parameters were determined:
change in skin type, the presence of cracks, abrasions, corns, peeling, etc., i.e. tests characterizing the functional state of the skin.

 In addition, antiperspirant, keratolytic and wound healing effects of foot balm were evaluated.

 2. The results of the study. An experimental study of subacute toxicity showed that the balm is not toxic with prolonged use in experimental animals. Behavior, general condition, appetite, skin and coat condition did not differ from the control. No pathological changes were noted in the structure of the skin and liver. It was found that foot balm does not have an irritating and allergenic effect.

 Proteolytic activity of the skin after the application of a cream containing collagenase was increased for both substrates in the experimental group compared to the control. However, when using casein as a substrate, this increase was very significant - more than 70%, while when using albumin - only 10%. This difference is apparently due to the fact that casein is a more specific substrate for collagenase than the globular albumin protein.

 Clinical studies have shown that the patchwork performed before the test was negative in all patients.

 Balm tolerance was satisfactory. No allergic or irritating effects were noted.

 It is established that balms are well absorbed into the skin and do not leave a greasy shine. Under his influence, the patients decreased sweating of the legs, hyperkeratosis and callosity of the feet, an unpleasant odor disappeared (deodorizing effect).

 He well shot the phenomena of inflammation and peeling, contributed to the healing of cracks, scuffs and microerosion.

 In addition, the balm has preventive properties, namely it prevents the occurrence of hyperkeratosis, inflammation and peeling on the feet.

 Thus, taking into account the positive data of experimental and clinical testing of the foot balm, we can conclude that this balm does not have an allergenic and local irritant effect, well removes inflammation, peeling, hyperkeratosis, and promotes the healing of microerosion. (see table).

 Example 1. Water, 1.0 triethanolamine, 1.0 urea, 0.5 boric or salicylic acid are charged into the reactor and heated.

 5.0 perfume oils, 7.0 vegetable oils, 5.0 mink fat, 2.0 stearin, 5.0 emulsion waxs, 5.0 monoglycerides of distilled 1.0 anhydrous lanolin or 1.0 ethanolated lanolin and melted. Next, the fat base is poured into the reactor. After emulsification, the mass is cooled. During cooling, 0.05 preservative, 1.0 phenoxyethanol, 5.0 ethyl alcohol, 1.0 camphor, 0.5 collagenase, 1.0 chitosan, 0.5 urotropine, 1.0 perfume are loaded into the emulsion.

 The finished cream is a homogeneous mass from white to light cream in color with a pleasant smell.

 Clinical and experimental studies have shown that the cream has anti-inflammatory, keratolytic, regenerating activity.

 Allergizing and irritating properties were not detected.

 Example 2. In the reactor load of 0.5 triethanolamine, 0.5 urea, 0.2 boric or salicylic acid, and heated.

 3.0 perfume oil, 5.0 vegetable oil, 3.0 mink fat, 0.5 stearin, 3.0 emulsion wax, 3.0 distilled monoglycerides, 1.0 anhydrous lanolin or 1.0 ethoxylated lanolin are loaded into the melting pot and melted. After complete melting, the fat base is poured into the reactor. After emulsification, the mass is cooled. During cooling, 0.05 preservative, 0.5 phenoxyethanol, 3.0 ethyl alcohol, 0.15 camphor, 0.1 collagenase, 0.5 chitosan, 0.2 perfume are loaded into the emulsion.

 The finished cream is a homogeneous mass from white to light cream in color with a pleasant smell.

 Clinical and experimental studies have shown that the cream has anti-inflammatory, keratolytic, regenerating activity.

 Allergizing and irritating properties were not detected.

 Thus, the presented examples illustrate the importance of the qualitative and quantitative composition of the proposed cream.

 In special studies, it was shown that going beyond the declared values of the ingredients of the composition in the direction of increasing or decreasing causes a deterioration in the organoleptic properties of the cream and a decrease in therapeutic and prophylactic activity. At the same time, the introduction of some alternative raw components into the composition does not adversely affect the properties of the cream.

 Thus, the proposed balm nourishes the skin of the legs, exerting a pronounced epithelizing and keratolytic effect on a rough, cracked surface, eliminates peeling and keratinous deposits, promotes the rapid healing of scuffs, abrasions, cracks, as well as the prevention of fungal diseases, deodorizes the skin of the legs.

 The balm has a soft consistency, is quickly absorbed, relieves fatigue and pain in the legs, improves overall well-being. It does not have an irritating and allergenic effect.

Bibliography
1. Villamo H. Cosmetic chemistry .- M.:, Mir, 1990, p. 175-179.

 2. Wojciechowska A.L. and other Cosmetics today.- M.: Chemistry, 1988, p. 39-41.

 3. Guske F. Alphabet of cosmetics. / Per. from German /.- M.: Medicine, 1973.

 4. Handbook of medical cosmetics. Ed. A.F. Akabadze. M. Medicine, 1976, 254 p.

Claims (1)

1. Foot balm containing vegetable oil, cosmetic stearin, triethanolamine, structure-forming components, urea, preservative, ethyl alcohol, camphor, perfume and water, characterized in that it additionally contains perfume oil, or butyl stearate, or isopropyl palmitate, or isopropyl myristate, deodorized mink fat, or mink oil, or chicken oil, or chicken oil, emulsion wax, anhydrous lanolin or hydroxyethylated lanolin, high molecular weight chitosan, boric or salicylic acid, phenoxyethane ol and collagenase, and as structure-forming components distilled monoglycerides (MHD) or glycerol monostearate or DEG stearate in the following ratios of components, wt.%:
Perfume oil or butyl stearate, or isopropyl palmitate, or isopropyl myristate - 3.0 - 5.0
Vegetable oil - 5.0 - 7.0
Deodorized mink fat, or mink oil, or chicken fat, or chicken oil - 3.0 - 5.0
Cosmetic stearin - 0.5 - 2.0
Triethanolamine - 0.5 - 1.0
Emulsion Wax - 3.0 - 5.0
Distilled monoglycerides (MHD), or glycerol monostearate, or DEG stearate - 3.0 - 5.0
Anhydrous lanolin or hydroxyethylated lanolin - Not more than 1.0
Ethyl alcohol - 3.0 - 5.0
Urea - 0.5 - 1.0
Camphor - 0.15 - 1.0
Boric acid or salicylic acid - 0.2 - 0.5
High molecular weight chitosan - 0.5 - 1.0
Collagenase - 0.1 - 0.5
Phenoxyethanol - 0.5 - 1.0
Preservative - 0.05
Fragrance - 0.2 - 1.0
Drinking water - Up to 100
2. Balm under item 1, characterized in that it additionally contains urotropin in an amount of not more than 0.5 wt.%.

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