RU2111958C1 - Способ получения 7-(замещенный)-9-[(замещенный глицил)амидо]-6-диметил-6-деокситетрациклинов - Google Patents

Способ получения 7-(замещенный)-9-[(замещенный глицил)амидо]-6-диметил-6-деокситетрациклинов Download PDF

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RU2111958C1
RU2111958C1 RU93043144A RU93043144A RU2111958C1 RU 2111958 C1 RU2111958 C1 RU 2111958C1 RU 93043144 A RU93043144 A RU 93043144A RU 93043144 A RU93043144 A RU 93043144A RU 2111958 C1 RU2111958 C1 RU 2111958C1
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Russia
Prior art keywords
methylpropyl
alpha
butyl
substituted
methyl
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RU93043144A
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English (en)
Russian (ru)
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RU93043144A (ru
Inventor
Сум Файк-Енг
Дж.Ли Винг
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Американ Цианамид Компани
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
RU93043144A 1992-08-13 1993-08-12 Способ получения 7-(замещенный)-9-[(замещенный глицил)амидо]-6-диметил-6-деокситетрациклинов RU2111958C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/928588 1992-08-13
US07/928,588 US5284963A (en) 1992-08-13 1992-08-13 Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US07/928,588 1992-08-13

Publications (2)

Publication Number Publication Date
RU93043144A RU93043144A (ru) 1996-12-27
RU2111958C1 true RU2111958C1 (ru) 1998-05-27

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RU93043144A RU2111958C1 (ru) 1992-08-13 1993-08-12 Способ получения 7-(замещенный)-9-[(замещенный глицил)амидо]-6-диметил-6-деокситетрациклинов

Country Status (27)

Country Link
US (1) US5284963A (https=)
EP (1) EP0582790B1 (https=)
JP (1) JP3590643B2 (https=)
KR (1) KR100250603B1 (https=)
CN (1) CN1037680C (https=)
AT (1) ATE174903T1 (https=)
AU (1) AU674689B2 (https=)
CA (1) CA2103837C (https=)
CZ (1) CZ286261B6 (https=)
DE (1) DE69322708T2 (https=)
DK (1) DK0582790T3 (https=)
ES (1) ES2125927T3 (https=)
FI (1) FI115722B (https=)
GR (1) GR3029764T3 (https=)
HU (1) HU222886B1 (https=)
IL (3) IL119551A (https=)
LV (1) LV12273B (https=)
MX (1) MX9304649A (https=)
NO (1) NO303574B1 (https=)
NZ (1) NZ248358A (https=)
PH (1) PH30150A (https=)
PL (2) PL173923B1 (https=)
RU (1) RU2111958C1 (https=)
SG (1) SG68556A1 (https=)
SK (1) SK281698B6 (https=)
TW (1) TW221285B (https=)
ZA (1) ZA935891B (https=)

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US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
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US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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Also Published As

Publication number Publication date
JPH06184075A (ja) 1994-07-05
PL300064A1 (en) 1994-02-21
US5284963A (en) 1994-02-08
FI933566A0 (fi) 1993-08-12
AU4460393A (en) 1994-02-17
CZ286261B6 (cs) 2000-02-16
IL106674A0 (en) 1993-12-08
CA2103837A1 (en) 1994-02-14
CN1083047A (zh) 1994-03-02
HU222886B1 (hu) 2003-12-29
SG68556A1 (en) 1999-11-16
FI933566L (fi) 1994-02-14
CN1037680C (zh) 1998-03-11
HU9302331D0 (en) 1993-10-28
DE69322708D1 (de) 1999-02-04
SK84993A3 (en) 1994-06-08
TW221285B (https=) 1994-02-21
IL106674A (en) 1998-07-15
JP3590643B2 (ja) 2004-11-17
PL173923B1 (pl) 1998-05-29
SK281698B6 (sk) 2001-07-10
NO932870D0 (no) 1993-08-12
ATE174903T1 (de) 1999-01-15
IL119551A (en) 2003-02-12
MX9304649A (es) 1994-02-28
IL119551A0 (en) 1997-02-18
EP0582790B1 (en) 1998-12-23
AU674689B2 (en) 1997-01-09
NO303574B1 (no) 1998-08-03
FI115722B (fi) 2005-06-30
ES2125927T3 (es) 1999-03-16
CA2103837C (en) 2004-10-05
DK0582790T3 (da) 1999-08-23
NO932870L (no) 1994-02-14
ZA935891B (en) 1994-03-09
HUT64941A (en) 1994-03-28
CZ157793A3 (en) 1994-03-16
LV12273B (en) 1999-11-20
NZ248358A (en) 1996-04-26
GR3029764T3 (en) 1999-06-30
LV12273A (lv) 1999-05-20
PH30150A (en) 1997-01-21
KR100250603B1 (ko) 2000-04-01
KR940003923A (ko) 1994-03-14
PL173606B1 (pl) 1998-03-31
DE69322708T2 (de) 1999-04-29
EP0582790A1 (en) 1994-02-16

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