RU2018123202A - Электрически активные гидрофильные биополимеры - Google Patents
Электрически активные гидрофильные биополимеры Download PDFInfo
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- RU2018123202A RU2018123202A RU2018123202A RU2018123202A RU2018123202A RU 2018123202 A RU2018123202 A RU 2018123202A RU 2018123202 A RU2018123202 A RU 2018123202A RU 2018123202 A RU2018123202 A RU 2018123202A RU 2018123202 A RU2018123202 A RU 2018123202A
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- 229920001222 biopolymer Polymers 0.000 title 1
- 238000000034 method Methods 0.000 claims 19
- 229920001577 copolymer Polymers 0.000 claims 11
- 239000000178 monomer Substances 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 6
- 230000002209 hydrophobic effect Effects 0.000 claims 6
- 239000003431 cross linking reagent Substances 0.000 claims 5
- 238000006116 polymerization reaction Methods 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical group N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical group COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 125000005399 allylmethacrylate group Chemical group 0.000 claims 2
- 229920001480 hydrophilic copolymer Polymers 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 239000003505 polymerization initiator Substances 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims 1
- QTKPMCIBUROOGY-UHFFFAOYSA-N 2,2,2-trifluoroethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(F)(F)F QTKPMCIBUROOGY-UHFFFAOYSA-N 0.000 claims 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- FIQBJLHOPOSODG-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxycarbonyl]benzoic acid Chemical compound CC(=C)C(=O)OCCOC(=O)C1=CC=CC=C1C(O)=O FIQBJLHOPOSODG-UHFFFAOYSA-N 0.000 claims 1
- BESKSSIEODQWBP-UHFFFAOYSA-N 3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C BESKSSIEODQWBP-UHFFFAOYSA-N 0.000 claims 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000000887 hydrating effect Effects 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 125000005395 methacrylic acid group Chemical group 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
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Claims (32)
1. Способ образования сшитого электронно-активного гидрофильного сополимера, включающий следующие стадии:
предоставление раствора сомономеров, содержащего по меньшей мере один гидрофобный мономер, по меньшей мере один гидрофильный мономер, воду, по меньшей мере одну аминокислоту и по меньшей мере один сшивающий агент, и
полимеризация данного раствора сомономеров.
2. Способ по п. 1, в котором по меньшей мере одна аминокислота выбрана из фенилаланина, триптофана, гистидина, этилендиаминтетрауксусной кислоты (EDTA) и тирозина или их комбинации.
3. Способ по п. 2, в котором по меньшей мере одна аминокислота выбрана из фенилаланина и триптофана или их комбинации.
4. Способ по любому из пп. 1-3, в котором по меньшей мере один гидрофильный мономер выбран из метакриловой кислоты, 2-гидроксиэтилметакрилата, этилакрилата, винилпирролидона, метилового эфира акриловой кислоты, монометакрилоилоксиэтилфталата, сульфатоэтилметакрилата аммония, поливинилового спирта или их комбинации.
5. Способ по п. 4, в котором по меньшей мере один гидрофильный мономер выбран из винилпирролидона и гидроксиэтилметакрилата или их комбинации.
6. Способ по любому из пп. 1-5, в котором по меньшей мере один гидрофобный мономер выбран из метилметакрилата, аллилметакрилата, акрилонитрила, метакрилоксипропилтрис(триметилсилокси)силана, 2,2,2-трифторэтилметакрилата или их комбинации.
7. Способ по п. 6, в котором по меньшей мере один гидрофобный мономер выбран из акрилонитрила и метилметакрилата или их комбинации.
8. Способ по любому из пп. 1-7, в котором сшивающий агент представляет собой аллилметакрилат или этиленгликольдиметакрилат.
9. Способ по любому из пп. 1-8, в котором как сшивающий агент, так и гидрофобный мономер представляет собой аллилметакрилат.
10. Способ по любому из пп. 1-9, в котором стадию полимеризации проводят посредством теплового, УФ (ультрафиолетовое) или гамма-излучения.
11. Способ по п. 10, в котором стадию полимеризации проводят посредством УФ- или гамма-излучения.
12. Способ по любому из пп. 1-11, в котором раствор сомономеров дополнительно содержит инициатор полимеризации.
13. Способ по п. 12, в котором инициатор полимеризации представляет собой азобисизобутиронитрил или 2-гидрокси-2-метилприофенон.
14. Способ по любому из пп. 1-13, в котором раствор сомономеров получают посредством добавления аминокислоты в форме твердого вещества к по меньшей мере одному из остальных компонентов раствора сомономеров.
15. Способ по любому из пп. 1-14, в котором раствор сомономеров получают посредством:
а. смешивания по меньшей мере одного гидрофобного мономера и по меньшей мере одного гидрофильного мономера в воде с образованием промежуточного раствора; и
б. добавления по меньшей мере одной аминокислоты и сшивающего агента к промежуточному раствору с образованием раствора сомономеров.
16. Способ по любому из пп. 1-15, дополнительно включающий стадию гидратации сополимера после полимеризации.
17. Способ по любому из пп. 1-16, в котором сополимер хранится в течение по меньшей мере 7 суток после гидратации.
18. Способ по п. 16, в котором сополимер гидратируется таким образом, что гидратированный сополимер содержит по меньшей мере 10 мас. % воды от общей массы гидратированного сополимера.
19. Гомогенный, изотропный, электронно-активный, гидрофильный сополимер, получаемый способом по любому из пп. 1-18.
20. Раствор сомономеров, содержащий по меньшей мере один гидрофобный мономер, по меньшей мере один гидрофильный мономер, воду, по меньшей мере одну аминокислоту и по меньшей мере один сшивающий агент.
21. Раствор сомономеров по п. 20, имеющий любую из дополнительных характеристик по пп. 2-9 или 12-13.
22. Биосовместимое медицинское устройство, содержащее сополимер по п. 19.
23. Гибкое биосовместимое устройство, контактирующее с нервами, содержащее сополимер по п. 19.
24. Кохлеарный имплантат, содержащий сополимер по п. 19.
25. Электрод искусственного водителя ритма, содержащий сополимер по п. 19.
26. Биосовместимое медицинское устройство, содержащее суперконденсатор, где суперконденсатор содержит два электрода и сополимер по п. 19, расположенный между ними.
27. Биосовместимое медицинское устройство по п. 26, где устройство представляет собой устройство, контактирующее с нервами, кохлеарный имплантат или искусственный водитель ритма.
28. Биосовместимая сенсорная система, содержащая сополимер по п. 19 с химическим компонентом, диспергированным по всей его структуре, где указанный химический компонент способен выявлять конкретное соединение.
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| GB0329459D0 (en) * | 2003-12-19 | 2004-01-28 | Itm Power Ltd | Hydrophilic materials used as ionically active membranes |
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| RU2463079C2 (ru) * | 2007-04-27 | 2012-10-10 | Эндо Фармасьютикалз Солюшнз Инк. | Разделительные агенты для имплантируемого устройства и способы их применения |
| GB201005947D0 (en) * | 2010-04-09 | 2010-05-26 | Highgate Donald J | Improvements to electrochemical systems |
| EP2889335B1 (en) * | 2012-08-21 | 2017-02-01 | Dainichiseika Color & Chemicals Mfg. Co., Ltd. | Aqueous liquid composition, aqueous coating liquid, functional coating film and composite material |
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| CN103265660B (zh) | 2013-06-09 | 2015-04-15 | 福州大学 | 双连续相微乳液原位聚合制备氨基酸分子印迹膜 |
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| CN109415643A (zh) * | 2016-03-31 | 2019-03-01 | 国立大学法人京都大学 | 润滑材料及srt材料 |
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| EP3397656A1 (en) | 2018-11-07 |
| RU2729643C2 (ru) | 2020-08-11 |
| CN108602906A (zh) | 2018-09-28 |
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