RU2015156779A - METHOD FOR PRODUCING DROTAVERINE HYDROCHLORIDE - Google Patents

METHOD FOR PRODUCING DROTAVERINE HYDROCHLORIDE Download PDF

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Publication number
RU2015156779A
RU2015156779A RU2015156779A RU2015156779A RU2015156779A RU 2015156779 A RU2015156779 A RU 2015156779A RU 2015156779 A RU2015156779 A RU 2015156779A RU 2015156779 A RU2015156779 A RU 2015156779A RU 2015156779 A RU2015156779 A RU 2015156779A
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RU
Russia
Prior art keywords
drotaverine hydrochloride
producing
orthodiethoxybenzene
carried out
chloride
Prior art date
Application number
RU2015156779A
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Russian (ru)
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RU2661150C9 (en
RU2661150C2 (en
Inventor
Людмила Александровна Солодухина
Людмила Александровна Абросимова
Ирина Владимировна Сивкова
Елизавета Павловна Подопригорова
Татьяна Александровна Егошина
Original Assignee
Открытое акционерное общество "Ирбитский химико-фармацевтический завод"
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Application filed by Открытое акционерное общество "Ирбитский химико-фармацевтический завод" filed Critical Открытое акционерное общество "Ирбитский химико-фармацевтический завод"
Priority to RU2015156779A priority Critical patent/RU2661150C9/en
Publication of RU2015156779A publication Critical patent/RU2015156779A/en
Application granted granted Critical
Publication of RU2661150C2 publication Critical patent/RU2661150C2/en
Publication of RU2661150C9 publication Critical patent/RU2661150C9/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (4)

1. Способ получения дротаверина гидрохлорида, по которому осуществляют последовательные операции по получению диэтоксифенилацетонитрила из ортодиэтоксибензола, диэтоксифенилуксусной кислоты и диэтоксифениламина, этоксиамида, технического и фармакопейного дротаверина гидрохлорида, при получении технического дротаверина гидрохлорида осуществляют циклизацию этоксиамида хлорокисью фосфора в среде трихлорэтилена с последующей фильтрацией и кристаллизацией.1. A method for the production of drotaverine hydrochloride, in which sequential operations are carried out to obtain diethoxyphenylacetonitrile from orthodiethoxybenzene, diethoxyphenylacetic acid and diethoxyphenylamine, ethoxyamide, technical and pharmacopoeial drotaverine hydrochloride, cyclically cyclization of ethoxychlorofluoromethylene phosphate dichloromethylene chloride is carried out in the preparation of technical drotaverine hydrochloride. 2. Способ получения дротаверина гидрохлорида по п. 1, отличающийся тем, что ортодиэтоксибензол получают этилированием пирокатехина диэтилсульфатом в щелочной среде с последующим выделением ортодиэтоксибензола отгонкой «острым» паром с последующими кристаллизацией и фильтрацией, удалением влаги из продукта и последующей его сушкой.2. The method of producing drotaverine hydrochloride according to claim 1, characterized in that orthodiethoxybenzene is obtained by ethylation of pyrocatechol with diethyl sulfate in an alkaline medium, followed by isolation of orthodiethoxybenzene by distillation with "hot" steam, followed by crystallization and filtration, removal of moisture from the product and its subsequent drying. 3. Способ получения дротаверина гидрохлорида по п. 1, отличающийся тем, что хлорметилирование ортодиэтоксибензола осуществляют с использованием формалина или параформальдегида и газообразного хлористого водорода в присутствии кальция хлористого или ортофосфорной кислоты с последующим растворением диэтоксибензилхлорида в трихлорэтилене.3. The method of producing drotaverine hydrochloride according to claim 1, characterized in that the chloromethylation of orthodiethoxybenzene is carried out using formalin or paraformaldehyde and hydrogen chloride gas in the presence of calcium chloride or phosphoric acid, followed by dissolution of diethoxybenzyl chloride in trichlorethylene. 4. Способ получения дротаверина гидрохлорида по п. 1, отличающийся тем, что цианирование диэтоксибензилхлорида осуществляют с применением межфазного катализа с использованием ацетона, триэтиламина, иодида калия.4. The method of producing drotaverine hydrochloride according to claim 1, characterized in that the cyanation of diethoxybenzyl chloride is carried out using interfacial catalysis using acetone, triethylamine, potassium iodide.
RU2015156779A 2015-12-29 2015-12-29 Method for preparation of drotaverine hydrochloride RU2661150C9 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2015156779A RU2661150C9 (en) 2015-12-29 2015-12-29 Method for preparation of drotaverine hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2015156779A RU2661150C9 (en) 2015-12-29 2015-12-29 Method for preparation of drotaverine hydrochloride

Publications (3)

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RU2015156779A true RU2015156779A (en) 2017-07-04
RU2661150C2 RU2661150C2 (en) 2018-07-12
RU2661150C9 RU2661150C9 (en) 2018-11-13

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RU2015156779A RU2661150C9 (en) 2015-12-29 2015-12-29 Method for preparation of drotaverine hydrochloride

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111170847A (en) * 2019-12-30 2020-05-19 江苏联环药业股份有限公司 Novel method for preparing drotaverine hydrochloride intermediate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT234693B (en) * 1961-08-30 1964-07-10 Chinoin Gyogyszer Es Vegyeszet Process for the preparation of new isoquinoline derivatives
RU2561489C2 (en) * 2013-05-14 2015-08-27 Вадим Петрович Бахарев Drotaverine synthesis method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111170847A (en) * 2019-12-30 2020-05-19 江苏联环药业股份有限公司 Novel method for preparing drotaverine hydrochloride intermediate
CN111170847B (en) * 2019-12-30 2022-02-18 江苏联环药业股份有限公司 Novel method for preparing drotaverine hydrochloride intermediate

Also Published As

Publication number Publication date
RU2661150C9 (en) 2018-11-13
RU2661150C2 (en) 2018-07-12

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