RU2014138476A - Триалкил катионные липиды и способы их использования - Google Patents

Триалкил катионные липиды и способы их использования Download PDF

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RU2014138476A
RU2014138476A RU2014138476A RU2014138476A RU2014138476A RU 2014138476 A RU2014138476 A RU 2014138476A RU 2014138476 A RU2014138476 A RU 2014138476A RU 2014138476 A RU2014138476 A RU 2014138476A RU 2014138476 A RU2014138476 A RU 2014138476A
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Джеймс ХЕЙС
Марк ВУД
Алан МАРТИН
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Протива Байотерапьютикс Инк.
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Abstract

1. Липид, имеющий структурную формулу (I):или его соль, где:X является алкиламиногруппой;А является от Cдо Cнеобязательно замещенным алкилом, где указанный необязательно замещенный C-C-алкил может быть насыщенным или ненасыщенным, и где А может присутствовать или может не присутствовать;Y выбран из группы, состоящей из кеталя, сложного эфира, необязательно замещенного карбамата, эфира, и необязательно замещенного амида; иZ является гидрофобным фрагментом, состоящим из трех алкильных цепей, где каждая из алкильных цепей имеет длину от Сдо С, где каждая из трех алкильных цепей может быть насыщенной или ненасыщенной, и где каждая из трех алкильных цепей является необязательно замещенной.2. Липид по п. 1, в котором каждая из алкильных цепей имеет длину от Cдо C.3. Липид по п. 1, в котором по меньшей мере одна алкиловая цепь имеет двойную связь.4. Липид по п. 1, в котором по меньшей мере одна алкильная цепь имеет цис-двойную связь.5. Липид по п. 1, в котором по меньшей мере одна алкильная цепь содержит циклоалкиловый фрагмент.6. Липид по п. 1, в котором X выбран из группы, состоящей из диметиламино-, диетиламино- и етилметиламиногруппы.7. Липид по п. 1, в котором А присутствует.8. Липид по п. 1, в котором Y является эфиром или кеталем.9. Липид по п. 1, в котором Y является необязательно замещенным карбаматом.10. Липид по п. 1, в котором Y является сложным эфиром.11. Липид по п. 1, в котором Y является необязательно замещенным амидом.12. Липид по п. 1, в котором Z имеет формулу:где R, Rи R, каждый отдельно, выбраны из группы, состоящей из от Сдо Салкила, где каждый из R, Rи Rможет независимо быть замещенным или незамещенным, и где каждый из R, Rи Rявляется необязательно замещенным.13. Липид по п. 1, который выбран из группы, состоящей из:14. Липидная частица, со

Claims (39)

1. Липид, имеющий структурную формулу (I):
Figure 00000001
или его соль, где:
X является алкиламиногруппой;
А является от C1 до C6 необязательно замещенным алкилом, где указанный необязательно замещенный C1-C6-алкил может быть насыщенным или ненасыщенным, и где А может присутствовать или может не присутствовать;
Y выбран из группы, состоящей из кеталя, сложного эфира, необязательно замещенного карбамата, эфира, и необязательно замещенного амида; и
Z является гидрофобным фрагментом, состоящим из трех алкильных цепей, где каждая из алкильных цепей имеет длину от С8 до С11, где каждая из трех алкильных цепей может быть насыщенной или ненасыщенной, и где каждая из трех алкильных цепей является необязательно замещенной.
2. Липид по п. 1, в котором каждая из алкильных цепей имеет длину от C9 до C10.
3. Липид по п. 1, в котором по меньшей мере одна алкиловая цепь имеет двойную связь.
4. Липид по п. 1, в котором по меньшей мере одна алкильная цепь имеет цис-двойную связь.
5. Липид по п. 1, в котором по меньшей мере одна алкильная цепь содержит циклоалкиловый фрагмент.
6. Липид по п. 1, в котором X выбран из группы, состоящей из диметиламино-, диетиламино- и етилметиламиногруппы.
7. Липид по п. 1, в котором А присутствует.
8. Липид по п. 1, в котором Y является эфиром или кеталем.
9. Липид по п. 1, в котором Y является необязательно замещенным карбаматом.
10. Липид по п. 1, в котором Y является сложным эфиром.
11. Липид по п. 1, в котором Y является необязательно замещенным амидом.
12. Липид по п. 1, в котором Z имеет формулу:
Figure 00000002
где R1, R2 и R3, каждый отдельно, выбраны из группы, состоящей из от С8 до С11 алкила, где каждый из R1, R2 и R3 может независимо быть замещенным или незамещенным, и где каждый из R1, R2 и R3 является необязательно замещенным.
13. Липид по п. 1, который выбран из группы, состоящей из:
Figure 00000003
Figure 00000004
Figure 00000005
14. Липидная частица, содержащая липид по любому из предшествующих пунктов.
15. Липидная частица по п. 14, в которой частица дополнительно содержит некатионный липид.
16. Липидная частица по п. 15, в которой некатионный липид выбран из группы, состоящей из фосфолипида, холестерина, или смеси фосфолипида и холестерина.
17. Липидная частица по п. 16, в которой фосфолипид содержит дипалмитоилфосфотидилхолин (DPPC), дистеароилфосфотидилхолин (DSPC), или их смесь.
18. Липидная частица по п. 16, в которой холестерин является производным холестерина.
19. Липидная частица по любому из пп. 14-18, в которой частица дополнительно содержит конъюгированный липид, который ингибирует агрегацию частиц.
20. Липидная частица по п. 19, в которой конъюгированный липид, который ингибирует агрегацию частиц, содержит полиэтиленгликоль (PEG)-липидный конъюгат.
21. Липидная частица по п. 20, в которой (РЕО)-липидный конъюгат содержит PEG-диацилглицероловый (PEG-DAG) конъюгат, PEG-диалкилоксипропиловый (PEG-DAA) конъюгат, или их смесь.
22. Липидная частица по п. 14, которая дополнительно содержит терапевтический агент.
23. Липидная частица по п. 22, в которой терапевтический агент является нуклеиновой кислотой.
24. Липидная частица по п. 23, в которой нуклеиновая кислота является интерферирующей РНК.
25. Липидная частица по п. 24, в которой интерферирующая РНК выбрана из группы, состоящей из малой интерферирующей РНК (миРНК), асимметричной интерферирующей РНК (аиРНК), микроРНК (микроРНК), дайсер-субстратной РНК дсРНК, малой шпилькой РНК (мшРНК), и их смесями.
26. Липидная частица по п. 25, в которой интерферирующая РНК является миРНК.
27. Липидная частица по п. 22, в которой терапевтический агент, по существу, не деградирует после инкубации частицы в сыворотке при 37°C в течение 30 мин.
28. Липидная частица по п. 22, в которой терапевтический агент полностью инкапсулирован в частицу.
29. Липидная частица по п. 22, в которой частица имеет массовое соотношение липид:терапевтический агент от примерно 5:1 до примерно 15:1.
30. Липидная частица по п. 14, которая имеет медианный диаметр от примерно 30 нм до примерно 150 нм.
31. Фармацевтическая композиция, содержащая липидную частицу по любому из пп. 14-30 и фармацевтически приемлемый носитель.
32. Способ введения терапевтического агента в клетку, включающий контактирование клетки с липидной частицей по п. 14.
33. Способ по п. 32, в котором клетка является клеткой млекопитающего.
34. Способ для доставки in vivo терапевтического агента, включающий введение млекопитающему липидной частицы по п. 14.
35. Способ по п. 34, в котором введение выбрано из группы, состоящей из перорального, интраназального, внутривенного, внутрибрюшинного, внутримышечного, внутрисуставного, внутриочагового, внутритрахеального, подкожного, и внутрикожного.
36. Способ по п. 34, в котором млекопитающее является человеком.
37. Способ лечения заболеваний или нарушений у млекопитающего, который в этом нуждается, включающий введение млекопитающему терапевтически эффективного количества липидной частицы по п. 14.
38. Способ по п. 37, где заболевание или нарушение выбрано из группы, состоящей из вирусной инфекции, заболевания или нарушения печени, и рака.
39. Способ по п. 37, отличающийся тем, что млекопитающее является человеком.
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