RU2013149745A - METHOD FOR DETERMINING HEREDITARY POSITION TO SENSITIZATION BY PRODUCTIVE ALLERGENS - Google Patents
METHOD FOR DETERMINING HEREDITARY POSITION TO SENSITIZATION BY PRODUCTIVE ALLERGENS Download PDFInfo
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- RU2013149745A RU2013149745A RU2013149745/15A RU2013149745A RU2013149745A RU 2013149745 A RU2013149745 A RU 2013149745A RU 2013149745/15 A RU2013149745/15 A RU 2013149745/15A RU 2013149745 A RU2013149745 A RU 2013149745A RU 2013149745 A RU2013149745 A RU 2013149745A
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Abstract
Способ определения наследственной предрасположенности к сенсибилизации производственными аллергенами, включающий забор венозной крови, выделение ДНК, проведение полимеразной цепной реакции со специфическими праймерами, определение нуклеотидной последовательности гена ФНОα в полиморфном положении 308, отличающийся тем, что при проведении полимеразной цепной реакции дополнительно определяют нуклеотидную последовательность в промоторной области гена ИЛ 4 в полиморфном положении 589, гена ИЛ 10 в полиморфном положении 819 и 1082 и на основании этого определяют полиморфные варианты генов ИЛ 4, ИЛ 10, ФНОα, при обнаружении гомозиготного АА генотипа гена ФНОα G308A и одновременно гомозиготного ТТ генотипа гена ИЛ 4 С589Т и/или гомозиготного ТТ генотипа гена ИЛ10 Т-819С и/или гомозиготного АА генотипа гена ИЛ10 A-1082G, определяют наследственную предрасположенность к сенсибилизации производственными аллергенами.A method for determining a hereditary predisposition to sensitization by industrial allergens, including venous blood sampling, DNA isolation, polymerase chain reaction with specific primers, determination of the nucleotide sequence of the TNFα gene in polymorphic position 308, characterized in that the nucleotide sequence in the promoter is additionally determined during the polymerase chain reaction regions of the IL 4 gene in the polymorphic position 589, the IL 10 gene in the polymorphic position 819 and 1082 and based and this determines the polymorphic variants of the IL 4, IL 10, TNFα genes when a homozygous AA genotype of the TNFα G308A gene is detected and at the same time a homozygous TT genotype of the IL 4 C589T gene and / or homozygous TT genotype of the IL10 T-819C gene and / or homozygous A10 genotype A A-1082G, determine a hereditary predisposition to sensitization by industrial allergens.
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RU2013149745/15A RU2564914C2 (en) | 2013-11-08 | 2013-11-08 | Method of determining hereditary predisposition to sensitisation with industrial allergens |
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RU2013149745/15A RU2564914C2 (en) | 2013-11-08 | 2013-11-08 | Method of determining hereditary predisposition to sensitisation with industrial allergens |
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RU2013149745A true RU2013149745A (en) | 2015-05-20 |
RU2564914C2 RU2564914C2 (en) | 2015-10-10 |
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RU2655658C1 (en) * | 2017-04-26 | 2018-05-29 | Федеральное бюджетное учреждение науки "Федеральный научный центр медико-профилактических технологий управления рисками здоровью населения" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН "ФНЦ медико-профилактических технологий управления рисками здоровью | Method of detecting disorders of physiological immunosuppression in children in first generation through parental lineage with hereditary tainted in conditions of aluminum excessive exposure |
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GB201110371D0 (en) * | 2011-06-17 | 2011-08-03 | Proteome Sciences R & D Gmbh & Co Kg | Materials and methods for determining sensitivity potential of compounds |
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