RU2008117760A - NON-2, 3-TRIMETHYL-2-ISOPROPHYLBUTAMIDE LOCATIC ACTION COMPOSITIONS AND METHODS OF APPLICATION - Google Patents

NON-2, 3-TRIMETHYL-2-ISOPROPHYLBUTAMIDE LOCATIC ACTION COMPOSITIONS AND METHODS OF APPLICATION Download PDF

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RU2008117760A
RU2008117760A RU2008117760/15A RU2008117760A RU2008117760A RU 2008117760 A RU2008117760 A RU 2008117760A RU 2008117760/15 A RU2008117760/15 A RU 2008117760/15A RU 2008117760 A RU2008117760 A RU 2008117760A RU 2008117760 A RU2008117760 A RU 2008117760A
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composition
trimethyl
isopropylbutamide
topical
patch
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RU2008117760/15A
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Russian (ru)
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RU2407522C2 (en
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Ютаро СУДО (US)
Ютаро СУДО
Юдзи МАТИДА (JP)
Юдзи МАТИДА
Сейитиро КАВАБАТА (JP)
Сейитиро КАВАБАТА
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ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. (US)
ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

1. Болеутоляющая композиция местного действия, содержащая эффективное болеутоляющее количество N, 2, 3-триметил-2-изопропилбутамида. ! 2. Композиция по п.1, отличающаяся тем, что содержит от приблизительно 0,1% до 30% N, 2, 3-триметил-2-изопропилбутамида. ! 3. Композиция по п.2, отличающаяся тем, что содержит от приблизительно 2% до 20% N, 2, 3-триметил-2-изопропилбутамида. ! 4. Композиция по п.1, представляющая собой пластырь местного действия. ! 5. Композиция по п.4, отличающаяся тем, что упомянутый пластырь местного действия представляет собой гидрогелевый пластырь. ! 6. Композиция по п.1, представляющая собой гель. ! 7. Композиция по п.1, представляющая собой крем. ! 8. Композиция по п.1, представляющая собой пену. ! 9. Способ лечения боли у пациента, испытывающего боль, включающий местное применение к упомянутому пациенту болеутоляющей композиции местного действия, содержащей количество N, 2, 3-триметил-2-изопропилбутамида, эффективно излечивающее упомянутую боль у упомянутого пациента. ! 10. Способ по п.9, отличающийся тем, что упомянутую композицию местного действия применяют к упомянутому пациенту местно на участке, ближайшем к болезненной области. ! 11. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия содержит от приблизительно 0,1 до 30% N, 2, 3-триметил-2-изопропилбутамида. ! 12. Способ по п.11, отличающийся тем, что упомянутая композиция местного действия содержит от приблизительно 2 до 20% N, 2, 3-триметил-2-изопропилбутамида. ! 13. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия представляет собой пластырь местного действия. ! 14. Способ по п.13, отличающийся тем, что упомянутый пластырь местного действия 1. A topical analgesic composition containing an effective analgesic amount of N, 2, 3-trimethyl-2-isopropylbutamide. ! 2. The composition according to claim 1, characterized in that it contains from about 0.1% to 30% N, 2, 3-trimethyl-2-isopropylbutamide. ! 3. The composition according to claim 2, characterized in that it contains from about 2% to 20% N, 2, 3-trimethyl-2-isopropylbutamide. ! 4. The composition according to claim 1, which is a patch of local action. ! 5. The composition according to claim 4, characterized in that the said local patch is a hydrogel patch. ! 6. The composition according to claim 1, which is a gel. ! 7. The composition according to claim 1, which is a cream. ! 8. The composition according to claim 1, which is a foam. ! 9. A method of treating pain in a patient experiencing pain, comprising topical application to the said patient of a topical analgesic composition containing an amount of N, 2, 3-trimethyl-2-isopropylbutamide, effectively treating said pain in said patient. ! 10. The method according to claim 9, characterized in that the said topical composition is applied to the said patient locally in the area closest to the painful area. ! 11. The method according to claim 9, characterized in that the said topical composition contains from about 0.1 to 30% N, 2, 3-trimethyl-2-isopropylbutamide. ! 12. The method according to claim 11, characterized in that the said topical composition contains from about 2 to 20% N, 2, 3-trimethyl-2-isopropylbutamide. ! 13. The method according to claim 9, characterized in that the said composition of local action is a patch of local action. ! 14. The method according to item 13, wherein the aforementioned patch of local action

Claims (24)

1. Болеутоляющая композиция местного действия, содержащая эффективное болеутоляющее количество N, 2, 3-триметил-2-изопропилбутамида.1. A topical analgesic composition containing an effective analgesic amount of N, 2, 3-trimethyl-2-isopropylbutamide. 2. Композиция по п.1, отличающаяся тем, что содержит от приблизительно 0,1% до 30% N, 2, 3-триметил-2-изопропилбутамида.2. The composition according to claim 1, characterized in that it contains from about 0.1% to 30% N, 2, 3-trimethyl-2-isopropylbutamide. 3. Композиция по п.2, отличающаяся тем, что содержит от приблизительно 2% до 20% N, 2, 3-триметил-2-изопропилбутамида.3. The composition according to claim 2, characterized in that it contains from about 2% to 20% N, 2, 3-trimethyl-2-isopropylbutamide. 4. Композиция по п.1, представляющая собой пластырь местного действия.4. The composition according to claim 1, which is a patch of local action. 5. Композиция по п.4, отличающаяся тем, что упомянутый пластырь местного действия представляет собой гидрогелевый пластырь.5. The composition according to claim 4, characterized in that the said local patch is a hydrogel patch. 6. Композиция по п.1, представляющая собой гель.6. The composition according to claim 1, which is a gel. 7. Композиция по п.1, представляющая собой крем.7. The composition according to claim 1, which is a cream. 8. Композиция по п.1, представляющая собой пену.8. The composition according to claim 1, which is a foam. 9. Способ лечения боли у пациента, испытывающего боль, включающий местное применение к упомянутому пациенту болеутоляющей композиции местного действия, содержащей количество N, 2, 3-триметил-2-изопропилбутамида, эффективно излечивающее упомянутую боль у упомянутого пациента.9. A method of treating pain in a patient experiencing pain, comprising topical application to the said patient of a topical analgesic composition containing an amount of N, 2, 3-trimethyl-2-isopropylbutamide, effectively treating said pain in said patient. 10. Способ по п.9, отличающийся тем, что упомянутую композицию местного действия применяют к упомянутому пациенту местно на участке, ближайшем к болезненной области.10. The method according to claim 9, characterized in that the said topical composition is applied to the said patient locally in the area closest to the painful area. 11. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия содержит от приблизительно 0,1 до 30% N, 2, 3-триметил-2-изопропилбутамида.11. The method according to claim 9, characterized in that said local composition contains from about 0.1 to 30% N, 2, 3-trimethyl-2-isopropylbutamide. 12. Способ по п.11, отличающийся тем, что упомянутая композиция местного действия содержит от приблизительно 2 до 20% N, 2, 3-триметил-2-изопропилбутамида.12. The method according to claim 11, characterized in that the said topical composition contains from about 2 to 20% N, 2, 3-trimethyl-2-isopropylbutamide. 13. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия представляет собой пластырь местного действия.13. The method according to claim 9, characterized in that the said composition of local action is a patch of local action. 14. Способ по п.13, отличающийся тем, что упомянутый пластырь местного действия представляет собой гидрогелевый пластырь.14. The method according to item 13, wherein the local patch is a hydrogel patch. 15. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия представляет собой гель.15. The method according to claim 9, characterized in that the said topical composition is a gel. 16. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия представляет собой крем.16. The method according to claim 9, characterized in that the said topical composition is a cream. 17. Способ по п.9, отличающийся тем, что упомянутая композиция местного действия представляет собой пену.17. The method according to claim 9, characterized in that the said topical composition is a foam. 18. Способ по п.9, отличающийся тем, что упомянутая боль выбрана из группы, которую составляют боль в спине, незначительные спортивные травмы, мигрень, тугоподвижность плеча, ревматический артрит, запястный сухожильный синдром, воспаление суставов, ушибы, мышечная усталость, переломы костей, рефлекторная симпатическая дистрофия и диабетическая боль.18. The method according to claim 9, characterized in that said pain is selected from the group consisting of back pain, minor sports injuries, migraine, shoulder stiffness, rheumatoid arthritis, carpal tendon syndrome, joint inflammation, bruises, muscle fatigue, bone fractures , reflex sympathetic dystrophy and diabetic pain. 19. Способ по п.9, отличающийся тем, что упомянутым пациентом является млекопитающее.19. The method according to claim 9, characterized in that the said patient is a mammal. 20. Способ по п.19, отличающийся тем, что упомянутым млекопитающим является человек.20. The method according to claim 19, characterized in that the said mammal is a human. 21. Набор, включающий:21. A kit comprising: (a) болеутоляющую композицию местного действия, содержащую эффективное болеутоляющее количество N, 2, 3-триметил-2-изопропилбутамида; и(a) a topical analgesic composition comprising an effective analgesic amount of N, 2, 3-trimethyl-2-isopropylbutamide; and (b) инструкции по применению упомянутой композиции для облегчения боли у пациента, нуждающегося в таком облегчении.(b) instructions for using said composition for pain relief in a patient in need of such relief. 22. Набор по п.21, отличающийся тем, что упомянутый набор включает несколько упомянутых композиций.22. The kit according to item 21, characterized in that the said kit includes several of these compositions. 23. Набор по п.22, отличающийся тем, что упомянутые несколько композиций находятся в отдельных контейнерах.23. The kit according to item 22, wherein the above-mentioned several compositions are in separate containers. 24. Набор по п.23, отличающийся тем, что упомянутыми отдельными контейнерами являются герметично закрытые упаковки. 24. The kit according to item 23, wherein the said individual containers are hermetically sealed packaging.
RU2008117760/15A 2005-10-24 2006-10-16 Topical analgesic compositions of n,2,3-trimethyl-2-isopropylbutamide and modes of administration thereof RU2407522C2 (en)

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US72984405P 2005-10-24 2005-10-24
US60/729,844 2005-10-24

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RU2407522C2 RU2407522C2 (en) 2010-12-27

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US (1) US20070093555A1 (en)
EP (1) EP1940377A4 (en)
JP (2) JP5128483B2 (en)
KR (1) KR20080035637A (en)
CN (1) CN101534805A (en)
AR (1) AR058141A1 (en)
AU (1) AU2006306563B2 (en)
BR (1) BRPI0613067A2 (en)
CA (1) CA2614345C (en)
MX (1) MX2008000486A (en)
NZ (1) NZ564014A (en)
RU (1) RU2407522C2 (en)
TW (1) TWI372047B (en)
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