RU2006125502A - Экспрессионные единицы psod - Google Patents
Экспрессионные единицы psod Download PDFInfo
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- RU2006125502A RU2006125502A RU2006125502/13A RU2006125502A RU2006125502A RU 2006125502 A RU2006125502 A RU 2006125502A RU 2006125502/13 A RU2006125502/13 A RU 2006125502/13A RU 2006125502 A RU2006125502 A RU 2006125502A RU 2006125502 A RU2006125502 A RU 2006125502A
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- Prior art keywords
- activity
- nucleic acids
- expression
- acids encoding
- microorganism
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- 230000014509 gene expression Effects 0.000 title claims 126
- 230000000694 effects Effects 0.000 claims 234
- 150000007523 nucleic acids Chemical class 0.000 claims 202
- 108020004707 nucleic acids Proteins 0.000 claims 180
- 102000039446 nucleic acids Human genes 0.000 claims 180
- 108090000623 proteins and genes Proteins 0.000 claims 130
- 244000005700 microbiome Species 0.000 claims 86
- 235000018102 proteins Nutrition 0.000 claims 54
- 102000004169 proteins and genes Human genes 0.000 claims 54
- 238000013518 transcription Methods 0.000 claims 29
- 230000035897 transcription Effects 0.000 claims 29
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 24
- 238000000034 method Methods 0.000 claims 23
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 21
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 16
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 13
- 239000004473 Threonine Substances 0.000 claims 13
- 102000001253 Protein Kinase Human genes 0.000 claims 12
- 102000011848 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Human genes 0.000 claims 11
- 101710088194 Dehydrogenase Proteins 0.000 claims 11
- 108010075604 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Proteins 0.000 claims 10
- 101000889837 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) Protein CysO Proteins 0.000 claims 9
- 108010055400 Aspartate kinase Proteins 0.000 claims 9
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims 9
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 9
- 108010053763 Pyruvate Carboxylase Proteins 0.000 claims 9
- 102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 claims 9
- 102000019394 Serine hydroxymethyltransferases Human genes 0.000 claims 9
- 235000003704 aspartic acid Nutrition 0.000 claims 9
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 9
- 230000015572 biosynthetic process Effects 0.000 claims 9
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 claims 8
- 108010064711 Homoserine dehydrogenase Proteins 0.000 claims 8
- 239000004472 Lysine Substances 0.000 claims 8
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 8
- 230000001105 regulatory effect Effects 0.000 claims 8
- OAJLVMGLJZXSGX-SLAFOUTOSA-L (2s,3s,4r,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7 Chemical compound [Co+3].O[C@H]1[C@@H](O)[C@@H]([CH2-])O[C@@H]1N1C2=NC=NC(N)=C2N=C1.[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-SLAFOUTOSA-L 0.000 claims 7
- 108010017464 Fructose-Bisphosphatase Proteins 0.000 claims 7
- 102000027487 Fructose-Bisphosphatase Human genes 0.000 claims 7
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims 7
- 108010022394 Threonine synthase Proteins 0.000 claims 7
- 102000006843 Threonine synthase Human genes 0.000 claims 7
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 claims 7
- 102000014701 Transketolase Human genes 0.000 claims 7
- 108010043652 Transketolase Proteins 0.000 claims 7
- 108010071598 homoserine kinase Proteins 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 claims 6
- 102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 claims 6
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 6
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 6
- 108010081616 FAD-dependent malate dehydrogenase Proteins 0.000 claims 6
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 102000003960 Ligases Human genes 0.000 claims 6
- 108090000364 Ligases Proteins 0.000 claims 6
- 108010022684 Phosphofructokinase-1 Proteins 0.000 claims 6
- 102000012435 Phosphofructokinase-1 Human genes 0.000 claims 6
- 108010042687 Pyruvate Oxidase Proteins 0.000 claims 6
- 108020004530 Transaldolase Proteins 0.000 claims 6
- 102100028601 Transaldolase Human genes 0.000 claims 6
- 229940024606 amino acid Drugs 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 6
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 6
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 6
- 108060006633 protein kinase Proteins 0.000 claims 6
- 108010023317 1-phosphofructokinase Proteins 0.000 claims 5
- 108091000044 4-hydroxy-tetrahydrodipicolinate synthase Proteins 0.000 claims 5
- 108030003594 Diaminopimelate decarboxylases Proteins 0.000 claims 5
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 5
- 101710116000 Phosphoadenosine phosphosulfate reductase Proteins 0.000 claims 5
- 108010053816 Sulfite Reductase (Ferredoxin) Proteins 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 229960002685 biotin Drugs 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N biotin Natural products N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 5
- 235000020958 biotin Nutrition 0.000 claims 5
- 239000011616 biotin Substances 0.000 claims 5
- 108010056578 diaminopimelate dehydrogenase Proteins 0.000 claims 5
- 230000004952 protein activity Effects 0.000 claims 5
- 230000037425 regulation of transcription Effects 0.000 claims 5
- 102000002249 Arginine-tRNA Ligase Human genes 0.000 claims 4
- 108010014885 Arginine-tRNA ligase Proteins 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 4
- 241000186146 Brevibacterium Species 0.000 claims 4
- 241000186216 Corynebacterium Species 0.000 claims 4
- 108010014468 Dihydrodipicolinate Reductase Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 101710083973 Homocysteine synthase Proteins 0.000 claims 4
- 108010061618 O-succinylhomoserine (thiol)-lyase Proteins 0.000 claims 4
- 229910019142 PO4 Inorganic materials 0.000 claims 4
- 108010006873 Threonine Dehydratase Proteins 0.000 claims 4
- 102000004357 Transferases Human genes 0.000 claims 4
- 108090000992 Transferases Proteins 0.000 claims 4
- 102000005924 Triose-Phosphate Isomerase Human genes 0.000 claims 4
- 108700015934 Triose-phosphate isomerases Proteins 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 229940088598 enzyme Drugs 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 108010034653 homoserine O-acetyltransferase Proteins 0.000 claims 4
- 238000003780 insertion Methods 0.000 claims 4
- 230000037431 insertion Effects 0.000 claims 4
- 239000010452 phosphate Substances 0.000 claims 4
- -1 phosphate aminosulfonate phosphate aminosulfonate Chemical compound 0.000 claims 4
- 230000014493 regulation of gene expression Effects 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 108010076010 Cystathionine beta-lyase Proteins 0.000 claims 3
- 108020005199 Dehydrogenases Proteins 0.000 claims 3
- 108010046335 Ferredoxin-NADP Reductase Proteins 0.000 claims 3
- 102000004316 Oxidoreductases Human genes 0.000 claims 3
- 108090000854 Oxidoreductases Proteins 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 3
- 108091022908 Serine O-acetyltransferase Proteins 0.000 claims 3
- 150000007513 acids Chemical class 0.000 claims 3
- 150000001491 aromatic compounds Chemical class 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 239000005515 coenzyme Substances 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 150000002009 diols Chemical class 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 230000002068 genetic effect Effects 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 101150052246 lrwd1 gene Proteins 0.000 claims 3
- 239000002777 nucleoside Substances 0.000 claims 3
- 125000003835 nucleoside group Chemical group 0.000 claims 3
- 150000007524 organic acids Chemical class 0.000 claims 3
- 235000005985 organic acids Nutrition 0.000 claims 3
- 102000020233 phosphotransferase Human genes 0.000 claims 3
- 239000011782 vitamin Substances 0.000 claims 3
- 235000013343 vitamin Nutrition 0.000 claims 3
- 229940088594 vitamin Drugs 0.000 claims 3
- 229930003231 vitamin Natural products 0.000 claims 3
- 102000015790 Asparaginase Human genes 0.000 claims 2
- 108010024976 Asparaginase Proteins 0.000 claims 2
- 108010005694 Aspartate 4-decarboxylase Proteins 0.000 claims 2
- 108010074122 Ferredoxins Proteins 0.000 claims 2
- 108010030837 Methylenetetrahydrofolate Reductase (NADPH2) Proteins 0.000 claims 2
- 102000005954 Methylenetetrahydrofolate Reductase (NADPH2) Human genes 0.000 claims 2
- 241000005308 Orsa Species 0.000 claims 2
- 102100021762 Phosphoserine phosphatase Human genes 0.000 claims 2
- 102000004523 Sulfate Adenylyltransferase Human genes 0.000 claims 2
- 108010022348 Sulfate adenylyltransferase Proteins 0.000 claims 2
- 230000037007 arousal Effects 0.000 claims 2
- 229960003272 asparaginase Drugs 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 claims 2
- 230000001851 biosynthetic effect Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 102000030592 phosphoserine aminotransferase Human genes 0.000 claims 2
- 108010088694 phosphoserine aminotransferase Proteins 0.000 claims 2
- 108010076573 phosphoserine phosphatase Proteins 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 210000003705 ribosome Anatomy 0.000 claims 2
- 229920002477 rna polymer Polymers 0.000 claims 2
- 238000013519 translation Methods 0.000 claims 2
- ISJHUKIGBLJDNA-DKWTVANSSA-N (2s)-2-amino-3-phosphonooxypropanoic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)[C@@H](N)COP(O)(O)=O ISJHUKIGBLJDNA-DKWTVANSSA-N 0.000 claims 1
- UWOCFOFVIBZJGH-UHFFFAOYSA-N 2,3-dihydrodipicolinic acid Chemical compound OC(=O)C1CC=CC(C(O)=O)=N1 UWOCFOFVIBZJGH-UHFFFAOYSA-N 0.000 claims 1
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 claims 1
- BIIYRTLYJCFEFQ-UHFFFAOYSA-N 3,4-diaminopyridine-2-carboxylic acid Chemical compound NC1=CC=NC(C(O)=O)=C1N BIIYRTLYJCFEFQ-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 108010000700 Acetolactate synthase Proteins 0.000 claims 1
- 102000001967 Branched-chain aminotransferases Human genes 0.000 claims 1
- 108050009223 Branched-chain aminotransferases Proteins 0.000 claims 1
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 1
- 102000004031 Carboxy-Lyases Human genes 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 101710155796 Malate:quinone oxidoreductase Proteins 0.000 claims 1
- 101710141619 Meso-diaminopimelate D-dehydrogenase Proteins 0.000 claims 1
- 108030006431 Methionine synthases Proteins 0.000 claims 1
- 108700027408 O-acetylhomoserine (thiol)-lyase Proteins 0.000 claims 1
- 239000005922 Phosphane Substances 0.000 claims 1
- 101001135788 Pinus taeda (+)-alpha-pinene synthase, chloroplastic Proteins 0.000 claims 1
- 102000003929 Transaminases Human genes 0.000 claims 1
- 108090000340 Transaminases Proteins 0.000 claims 1
- 229950006137 dexfosfoserine Drugs 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- GMKMEZVLHJARHF-SYDPRGILSA-N meso-2,6-diaminopimelic acid Chemical compound [O-]C(=O)[C@@H]([NH3+])CCC[C@@H]([NH3+])C([O-])=O GMKMEZVLHJARHF-SYDPRGILSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 229910000064 phosphane Inorganic materials 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10359660A DE10359660A1 (de) | 2003-12-18 | 2003-12-18 | Psod-Expressionseinheiten |
| DE10359660.7 | 2003-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006125502A true RU2006125502A (ru) | 2008-01-27 |
Family
ID=34683563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006125502/13A RU2006125502A (ru) | 2003-12-18 | 2004-12-16 | Экспрессионные единицы psod |
Country Status (15)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4035855B2 (ja) † | 1996-06-05 | 2008-01-23 | 味の素株式会社 | Ｌ−リジンの製造法 |
| DE10359594A1 (de) | 2003-12-18 | 2005-07-28 | Basf Ag | PEF-TU-Expressionseinheiten |
| DE102004035065A1 (de) | 2004-07-20 | 2006-02-16 | Basf Ag | P-ET-TS-Expressionseinheiten |
| DE102004061846A1 (de) * | 2004-12-22 | 2006-07-13 | Basf Ag | Mehrfachpromotoren |
| DE102005056668A1 (de) * | 2005-11-28 | 2007-05-31 | Basf Ag | Fermentative Herstellung organischer Verbindungen |
| EP2386650B1 (en) * | 2006-04-07 | 2013-07-03 | Evonik Degussa GmbH | Method for producing L-amino acids using the gap promoter |
| EP1881076A1 (en) * | 2006-07-17 | 2008-01-23 | Evonik Degussa GmbH | Method for producing L-amino acids |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| DE102009030342A1 (de) | 2009-06-25 | 2010-12-30 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von organisch chemischen Verbindungen |
| US20120295317A1 (en) | 2009-12-17 | 2012-11-22 | Basf Se | Processes and Recombinant Microorganisms for the Production of Cadaverine |
| DE102010003419B4 (de) | 2010-03-30 | 2019-09-12 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von L-Ornithin |
| US9968030B2 (en) | 2010-06-22 | 2018-05-15 | Cnh Industrial Canada, Ltd. | Down pressure adjustment device and method for use with a disc opener assembly of an agricultural implement |
| WO2012114256A1 (en) | 2011-02-22 | 2012-08-30 | Basf Se | Processes and recombinant microorganisms for the production of cadaverine |
| DE102011006716A1 (de) | 2011-04-04 | 2012-10-04 | Evonik Degussa Gmbh | Mikroorganismus und Verfahren zur fermentativen Herstellung einer organisch-chemischen Verbindung |
| DE102011118019A1 (de) | 2011-06-28 | 2013-01-03 | Evonik Degussa Gmbh | Varianten des Promotors des für die Glyzerinaldehyd-3-phosphat-Dehydrogenase kodierenden gap-Gens |
| KR101335853B1 (ko) * | 2011-12-01 | 2013-12-02 | 씨제이제일제당 (주) | Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법 |
| EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
| CN107257856B (zh) | 2014-10-30 | 2021-05-28 | 株式会社三养社 | 阿洛酮糖差向异构酶的表达系统和使用其生产阿洛酮糖 |
| WO2016091980A1 (en) | 2014-12-10 | 2016-06-16 | Basf Se | Method of removing dna from biotechnological products |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| EP3415622A1 (en) | 2017-06-14 | 2018-12-19 | Evonik Degussa GmbH | Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases |
| CN109536465B (zh) * | 2017-09-21 | 2020-11-13 | 中国医学科学院医药生物技术研究所 | 筛选抗结核药物的组合物、筛选模型和筛选方法 |
| CN109182235B (zh) * | 2018-08-29 | 2021-03-30 | 江南大学 | 一种n端序列元件在调控枯草芽孢杆菌表达蛋白中的应用 |
| CN111549027A (zh) * | 2020-04-28 | 2020-08-18 | 天津大学 | 一种谷氨酸棒杆菌高强度启动子Psod-sx及应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696561B1 (en) * | 1909-07-09 | 2004-02-24 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport |
| JPS5835197A (ja) | 1981-08-26 | 1983-03-01 | Kyowa Hakko Kogyo Co Ltd | プラスミドｐｃｇ２ |
| US4601893A (en) | 1984-02-08 | 1986-07-22 | Pfizer Inc. | Laminate device for controlled and prolonged release of substances to an ambient environment and method of use |
| GB2165546B (en) | 1984-08-21 | 1989-05-17 | Asahi Chemical Ind | A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom |
| DE4027453A1 (de) | 1990-08-30 | 1992-03-05 | Degussa | Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren |
| EP0693558B1 (en) | 1994-07-19 | 2002-12-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Trehalose and its production and use |
| DE4440118C1 (de) * | 1994-11-11 | 1995-11-09 | Forschungszentrum Juelich Gmbh | Die Genexpression in coryneformen Bakterien regulierende DNA |
| JPH10229891A (ja) | 1997-02-20 | 1998-09-02 | Mitsubishi Rayon Co Ltd | マロン酸誘導体の製造法 |
| KR20070087094A (ko) * | 1999-06-25 | 2007-08-27 | 바스프 악티엔게젤샤프트 | 스트레스 저항성 및 내성 단백질을 코딩하는코리네박테리움 글루타미쿰 유전자 |
| SK18872001A3 (sk) * | 1999-06-25 | 2002-12-03 | Basf Aktiengesellschaft | Gény Corynebacterium glutamicum kódujúce proteíny zapojené do metabolizmu uhlíka a produkcie energie |
| US6822084B1 (en) * | 1999-06-25 | 2004-11-23 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins |
| CN1451047A (zh) * | 1999-06-25 | 2003-10-22 | Basf公司 | 编码胁迫、抗性和耐受性蛋白的谷氨酸棒杆菌基因 |
| US7270984B1 (en) * | 1999-06-25 | 2007-09-18 | Basf Aktiengesellschaft | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum |
| JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
| DE10046870A1 (de) | 2000-09-20 | 2002-03-28 | Basf Ag | Verfahren zur Veränderung des Genoms von Corynebakterien |
| AU2002230431A1 (en) * | 2000-11-15 | 2002-05-27 | Archer-Daniels-Midland Company | Corynebacterium glutamicum promoters |
| KR100602807B1 (ko) * | 2001-03-30 | 2006-07-20 | 아지노모토 가부시키가이샤 | 단백질의 분비 생산 방법 |
-
2003
- 2003-12-18 DE DE10359660A patent/DE10359660A1/de not_active Withdrawn
-
2004
- 2004-12-15 TW TW93138851A patent/TW200602489A/zh unknown
- 2004-12-16 AT AT04803950T patent/ATE486131T1/de not_active IP Right Cessation
- 2004-12-16 JP JP2006544337A patent/JP2007514426A/ja not_active Withdrawn
- 2004-12-16 RU RU2006125502/13A patent/RU2006125502A/ru not_active Application Discontinuation
- 2004-12-16 CN CNA2004800378819A patent/CN1894411A/zh active Pending
- 2004-12-16 CA CA002549171A patent/CA2549171A1/en not_active Abandoned
- 2004-12-16 WO PCT/EP2004/014337 patent/WO2005059144A1/de active Application Filing
- 2004-12-16 KR KR1020067014366A patent/KR20070004580A/ko not_active Withdrawn
- 2004-12-16 EP EP07123778A patent/EP1918378A1/de not_active Ceased
- 2004-12-16 CN CN2007103011915A patent/CN101230351B/zh not_active Expired - Fee Related
- 2004-12-16 BR BRPI0417728-2A patent/BRPI0417728A/pt not_active IP Right Cessation
- 2004-12-16 EP EP04803950A patent/EP1697526B1/de not_active Expired - Lifetime
- 2004-12-16 US US10/583,191 patent/US20080274516A1/en not_active Abandoned
- 2004-12-16 DE DE502004011835T patent/DE502004011835D1/de not_active Expired - Lifetime
- 2004-12-17 AR ARP040104737A patent/AR047152A1/es not_active Application Discontinuation
-
2006
- 2006-07-17 ZA ZA2006/05857A patent/ZA200605857B/en unknown
- 2006-07-17 IN IN2599CH2006 patent/IN2006CH02599A/en unknown
-
2008
- 2008-02-13 US US12/030,575 patent/US8071365B2/en active Active
- 2008-04-02 JP JP2008095699A patent/JP4800341B2/ja not_active Expired - Fee Related
- 2008-08-18 IN IN416CH2008 patent/IN2008CH00416A/en unknown
-
2009
- 2009-08-24 US US12/546,651 patent/US20100062535A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200602489A (en) | 2006-01-16 |
| CN1894411A (zh) | 2007-01-10 |
| ATE486131T1 (de) | 2010-11-15 |
| WO2005059144A1 (de) | 2005-06-30 |
| CA2549171A1 (en) | 2005-06-30 |
| ZA200605857B (en) | 2008-01-08 |
| US20090004705A1 (en) | 2009-01-01 |
| JP2007514426A (ja) | 2007-06-07 |
| DE502004011835D1 (de) | 2010-12-09 |
| CN101230351A (zh) | 2008-07-30 |
| IN2008CH00416A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2008-09-19 |
| US8071365B2 (en) | 2011-12-06 |
| JP4800341B2 (ja) | 2011-10-26 |
| EP1697526B1 (de) | 2010-10-27 |
| US20100062535A1 (en) | 2010-03-11 |
| DE10359660A1 (de) | 2005-07-28 |
| BRPI0417728A (pt) | 2007-04-03 |
| CN101230351B (zh) | 2013-02-20 |
| US20080274516A1 (en) | 2008-11-06 |
| AR047152A1 (es) | 2006-01-11 |
| IN2006CH02599A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2007-06-08 |
| EP1697526A1 (de) | 2006-09-06 |
| KR20070004580A (ko) | 2007-01-09 |
| JP2008212154A (ja) | 2008-09-18 |
| EP1918378A1 (de) | 2008-05-07 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20081020 |